INIP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a subunit of single-stranded DNA binding complexes that are important for maintaining genome stability. These complexes are involved in G2/M checkpoint control and homologous recombination repair. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.31429375
2telomere maintenance via semi-conservative replication (GO:0032201)4.98969951
3DNA strand elongation involved in DNA replication (GO:0006271)4.95092664
4DNA strand elongation (GO:0022616)4.76471131
5ribosomal small subunit assembly (GO:0000028)4.72517407
6DNA replication initiation (GO:0006270)4.53000489
7telomere maintenance via recombination (GO:0000722)4.45599520
8replication fork processing (GO:0031297)4.42012822
9mitotic recombination (GO:0006312)4.16643369
10response to pheromone (GO:0019236)4.10272187
11DNA replication checkpoint (GO:0000076)4.00953530
12deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.94356778
13CENP-A containing nucleosome assembly (GO:0034080)3.92706433
14DNA unwinding involved in DNA replication (GO:0006268)3.88993250
15telomere maintenance via telomere lengthening (GO:0010833)3.88553429
16protein-cofactor linkage (GO:0018065)3.86535488
17chromatin remodeling at centromere (GO:0031055)3.86095593
18kinetochore organization (GO:0051383)3.80532808
19nucleotide-excision repair, DNA gap filling (GO:0006297)3.78972936
20L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.71416787
21viral transcription (GO:0019083)3.71319391
22imidazole-containing compound metabolic process (GO:0052803)3.71180326
23signal peptide processing (GO:0006465)3.70483834
24behavioral response to nicotine (GO:0035095)3.67658796
25kinetochore assembly (GO:0051382)3.67040116
26translational termination (GO:0006415)3.63514769
27ribosomal small subunit biogenesis (GO:0042274)3.60878627
28detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.54553885
29DNA replication-independent nucleosome assembly (GO:0006336)3.53421144
30DNA replication-independent nucleosome organization (GO:0034724)3.53421144
31ribosomal large subunit biogenesis (GO:0042273)3.43587262
32resolution of meiotic recombination intermediates (GO:0000712)3.42788460
33respiratory chain complex IV assembly (GO:0008535)3.40041603
34maturation of SSU-rRNA (GO:0030490)3.38998449
35negative regulation of telomere maintenance (GO:0032205)3.36975567
36pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.28669544
37protein complex biogenesis (GO:0070271)3.28120543
38regulation of double-strand break repair via homologous recombination (GO:0010569)3.28114594
39protein localization to kinetochore (GO:0034501)3.27806656
40regulation of nuclear cell cycle DNA replication (GO:0033262)3.24177188
41water-soluble vitamin biosynthetic process (GO:0042364)3.24063114
42platelet dense granule organization (GO:0060155)3.22367764
43centriole replication (GO:0007099)3.21812169
44regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.21113251
45attachment of spindle microtubules to kinetochore (GO:0008608)3.16013595
46mitochondrial respiratory chain complex I assembly (GO:0032981)3.15351903
47NADH dehydrogenase complex assembly (GO:0010257)3.15351903
48mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.15351903
49postreplication repair (GO:0006301)3.14973781
50recombinational repair (GO:0000725)3.14530402
51translational elongation (GO:0006414)3.14425000
52mitochondrial respiratory chain complex assembly (GO:0033108)3.13893565
53SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.12840758
54telomere organization (GO:0032200)3.12163689
55L-methionine biosynthetic process (GO:0071265)3.11930650
56amino acid salvage (GO:0043102)3.11930650
57L-methionine salvage (GO:0071267)3.11930650
58double-strand break repair via homologous recombination (GO:0000724)3.11885871
59telomere maintenance (GO:0000723)3.10759048
60mitotic metaphase plate congression (GO:0007080)3.09148881
61pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.08962656
62regulation of glucokinase activity (GO:0033131)3.08531742
63regulation of hexokinase activity (GO:1903299)3.08531742
64protein localization to chromosome, centromeric region (GO:0071459)3.06779447
65cotranslational protein targeting to membrane (GO:0006613)3.04506341
66histone exchange (GO:0043486)3.04226867
67protein targeting to ER (GO:0045047)3.00716447
68nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.00273518
69spliceosomal snRNP assembly (GO:0000387)2.98568402
70sequestering of actin monomers (GO:0042989)2.98248068
71ribonucleoprotein complex biogenesis (GO:0022613)2.97276952
72exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.97089291
73translational initiation (GO:0006413)2.97015164
74mannosylation (GO:0097502)2.96460023
75DNA ligation (GO:0006266)2.94751736
76establishment of integrated proviral latency (GO:0075713)2.94738501
77mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.94466161
78histone mRNA metabolic process (GO:0008334)2.92173702
79nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.91472689
80deoxyribonucleotide biosynthetic process (GO:0009263)2.90699965
81somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.90230290
82somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.90230290
83isotype switching (GO:0045190)2.90230290
84cytochrome complex assembly (GO:0017004)2.90152762
85regulation of meiosis I (GO:0060631)2.89977475
86mismatch repair (GO:0006298)2.89492577
87intra-S DNA damage checkpoint (GO:0031573)2.88814808
88preassembly of GPI anchor in ER membrane (GO:0016254)2.88387651
89transcription-coupled nucleotide-excision repair (GO:0006283)2.87765944
90maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.85962678
91mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.85648393
92rRNA processing (GO:0006364)2.85474875
93anterograde synaptic vesicle transport (GO:0048490)2.85322692
94cellular protein complex disassembly (GO:0043624)2.84059064
95establishment of protein localization to endoplasmic reticulum (GO:0072599)2.82649463
96pseudouridine synthesis (GO:0001522)2.81512061
97negative regulation of mast cell activation (GO:0033004)2.81497920
98protein localization to endoplasmic reticulum (GO:0070972)2.81048315
99metaphase plate congression (GO:0051310)2.80037867
100neural tube formation (GO:0001841)2.79846081
101DNA replication-dependent nucleosome organization (GO:0034723)2.79051343
102DNA replication-dependent nucleosome assembly (GO:0006335)2.79051343
103viral life cycle (GO:0019058)2.78715854
104prenylation (GO:0097354)2.77058290
105protein prenylation (GO:0018342)2.77058290
106rRNA metabolic process (GO:0016072)2.77017310
107proteasome assembly (GO:0043248)2.76122917
108tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.75912288
109RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.75912288
110cellular ketone body metabolic process (GO:0046950)2.75687051
111negative regulation of RNA splicing (GO:0033119)2.75184952
112maturation of 5.8S rRNA (GO:0000460)2.74996244
113cullin deneddylation (GO:0010388)2.72600690
114positive regulation of oligodendrocyte differentiation (GO:0048714)2.72443729
115meiotic chromosome segregation (GO:0045132)2.72302794
116methionine biosynthetic process (GO:0009086)2.71517738
117kynurenine metabolic process (GO:0070189)2.71311495
118somatic recombination of immunoglobulin gene segments (GO:0016447)2.69987808
119translesion synthesis (GO:0019985)2.69821899
120negative regulation of DNA-dependent DNA replication (GO:2000104)2.68593488
121protein deneddylation (GO:0000338)2.67074839
122ketone body metabolic process (GO:1902224)2.66835060
123regulation of helicase activity (GO:0051095)2.66515348
124histone H2A acetylation (GO:0043968)2.66260395
125adenosine metabolic process (GO:0046085)2.66216717
126establishment of protein localization to mitochondrial membrane (GO:0090151)2.65869849
127viral mRNA export from host cell nucleus (GO:0046784)2.64903115
128nucleobase biosynthetic process (GO:0046112)2.64847348
129nuclear-transcribed mRNA catabolic process (GO:0000956)2.63488820
130base-excision repair (GO:0006284)2.63097868
131protein complex disassembly (GO:0043241)2.63079095
132negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.62788694
133DNA replication (GO:0006260)2.62632193
134protein K6-linked ubiquitination (GO:0085020)2.62051070
135somatic hypermutation of immunoglobulin genes (GO:0016446)2.60925856
136somatic diversification of immune receptors via somatic mutation (GO:0002566)2.60925856
137somatic diversification of immunoglobulins (GO:0016445)2.60092153
138DNA recombination (GO:0006310)2.59872204
139peptidyl-histidine modification (GO:0018202)2.59861638
140C-terminal protein lipidation (GO:0006501)2.59847378
141cellular biogenic amine biosynthetic process (GO:0042401)2.58854736
142DNA catabolic process, exonucleolytic (GO:0000738)2.58070259
143fucose catabolic process (GO:0019317)2.57463819
144L-fucose metabolic process (GO:0042354)2.57463819
145L-fucose catabolic process (GO:0042355)2.57463819
146reciprocal meiotic recombination (GO:0007131)2.57406013
147reciprocal DNA recombination (GO:0035825)2.57406013
148cell cycle G1/S phase transition (GO:0044843)2.57073310
149G1/S transition of mitotic cell cycle (GO:0000082)2.57073310
150establishment of chromosome localization (GO:0051303)2.56925403
151regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.56915886
152somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.56113972
153somatic cell DNA recombination (GO:0016444)2.56113972
154ribosome biogenesis (GO:0042254)2.55836140
155protein localization to cilium (GO:0061512)2.55775621
156DNA double-strand break processing (GO:0000729)2.55721146
157ATP-dependent chromatin remodeling (GO:0043044)2.55274952
158termination of RNA polymerase II transcription (GO:0006369)2.55231508
159cilium morphogenesis (GO:0060271)2.54766455
160indolalkylamine metabolic process (GO:0006586)2.53978944
161RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.53922080
162chromatin assembly or disassembly (GO:0006333)2.53539166
163regulation of acyl-CoA biosynthetic process (GO:0050812)2.53354699
164mRNA catabolic process (GO:0006402)2.53311617
165energy coupled proton transport, down electrochemical gradient (GO:0015985)2.52687364
166ATP synthesis coupled proton transport (GO:0015986)2.52687364
167synapsis (GO:0007129)2.51837425
168spliceosomal complex assembly (GO:0000245)2.51514549
169DNA duplex unwinding (GO:0032508)2.51043829
170pyrimidine nucleotide catabolic process (GO:0006244)2.50866177
171C-terminal protein amino acid modification (GO:0018410)2.50402637
172nonmotile primary cilium assembly (GO:0035058)2.49358178
173catechol-containing compound biosynthetic process (GO:0009713)2.49067484
174catecholamine biosynthetic process (GO:0042423)2.49067484
175nucleotide transmembrane transport (GO:1901679)2.47985363
176negative regulation of DNA recombination (GO:0045910)2.47932744
177tryptophan catabolic process (GO:0006569)2.47548880
178indole-containing compound catabolic process (GO:0042436)2.47548880
179indolalkylamine catabolic process (GO:0046218)2.47548880
180regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.47416984
181regulation of mitotic spindle checkpoint (GO:1903504)2.47416984
182male meiosis (GO:0007140)2.46960837
183tryptophan metabolic process (GO:0006568)2.46273436
184electron transport chain (GO:0022900)2.44300835

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.85473674
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.02925894
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.81076431
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.57073696
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.35453136
6ZNF274_21170338_ChIP-Seq_K562_Hela3.19850378
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.12854241
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.09696767
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.09107108
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.97515480
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.94416647
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.93185442
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.85104448
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.80685700
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.68886134
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.68447287
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.54969399
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.50601028
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.48681597
20VDR_22108803_ChIP-Seq_LS180_Human2.46191744
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.45073057
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.44611338
23IGF1R_20145208_ChIP-Seq_DFB_Human2.42226240
24GBX2_23144817_ChIP-Seq_PC3_Human2.34702515
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.32441328
26EWS_26573619_Chip-Seq_HEK293_Human2.30398857
27VDR_23849224_ChIP-Seq_CD4+_Human2.29595954
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.28928941
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.27281430
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.22343942
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.16435377
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.16044647
33FOXP3_21729870_ChIP-Seq_TREG_Human2.13614992
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.12659984
35FUS_26573619_Chip-Seq_HEK293_Human2.12020365
36SALL1_21062744_ChIP-ChIP_HESCs_Human2.10291658
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.08954262
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.08510382
39XRN2_22483619_ChIP-Seq_HELA_Human2.05375011
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.05071054
41FLI1_27457419_Chip-Seq_LIVER_Mouse2.04455522
42E2F1_21310950_ChIP-Seq_MCF-7_Human2.03199117
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.99874009
44CREB1_15753290_ChIP-ChIP_HEK293T_Human1.99818819
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.98973024
46P300_19829295_ChIP-Seq_ESCs_Human1.97555360
47TAF15_26573619_Chip-Seq_HEK293_Human1.97434486
48ER_23166858_ChIP-Seq_MCF-7_Human1.97115405
49NELFA_20434984_ChIP-Seq_ESCs_Mouse1.96673532
50* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.92473325
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.91282609
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.90155180
53TP63_19390658_ChIP-ChIP_HaCaT_Human1.87843312
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.87246226
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.86917546
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85631313
57CIITA_25753668_ChIP-Seq_RAJI_Human1.84498342
58TTF2_22483619_ChIP-Seq_HELA_Human1.84039435
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.79761458
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79050895
61ELK1_19687146_ChIP-ChIP_HELA_Human1.77303370
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.76062761
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.74868495
64DCP1A_22483619_ChIP-Seq_HELA_Human1.72791872
65IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.70777169
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.70507920
67E2F1_18555785_ChIP-Seq_MESCs_Mouse1.69755093
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66346656
69GABP_19822575_ChIP-Seq_HepG2_Human1.63304896
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.63171363
71E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.59269886
72YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58327664
73SRF_21415370_ChIP-Seq_HL-1_Mouse1.58192653
74PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57490139
75TP53_22573176_ChIP-Seq_HFKS_Human1.55482295
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54503489
77MYCN_18555785_ChIP-Seq_MESCs_Mouse1.51824770
78MYC_22102868_ChIP-Seq_BL_Human1.50090755
79YY1_21170310_ChIP-Seq_MESCs_Mouse1.49745491
80HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.49467650
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.49148392
82SPI1_23547873_ChIP-Seq_NB4_Human1.47932120
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47260182
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.44013284
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43492547
86AR_21909140_ChIP-Seq_LNCAP_Human1.41448273
87SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40117967
88ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.39133927
89MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.38951275
90SCL_19346495_ChIP-Seq_HPC-7_Human1.37068305
91EGR1_19374776_ChIP-ChIP_THP-1_Human1.36141525
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36122952
93CBP_20019798_ChIP-Seq_JUKART_Human1.36122952
94EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34664724
95NFE2_27457419_Chip-Seq_LIVER_Mouse1.32644305
96SMAD4_21799915_ChIP-Seq_A2780_Human1.32498037
97GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.30456050
98SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30348622
99STAT3_23295773_ChIP-Seq_U87_Human1.30326105
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30171935
101UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27998400
102GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26811935
103IRF8_21731497_ChIP-ChIP_J774_Mouse1.26678720
104BCAT_22108803_ChIP-Seq_LS180_Human1.26611361
105KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.26364328
106NANOG_18555785_Chip-Seq_ESCs_Mouse1.26298371
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26054832
108POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.25866427
109AR_25329375_ChIP-Seq_VCAP_Human1.25744869
110OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24699738
111SOX2_19829295_ChIP-Seq_ESCs_Human1.24498509
112NANOG_19829295_ChIP-Seq_ESCs_Human1.24498509
113MYC_18940864_ChIP-ChIP_HL60_Human1.23934811
114PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23322222
115ZFX_18555785_ChIP-Seq_MESCs_Mouse1.22062908
116EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21856862
117SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21237001
118PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19758441
119P53_22387025_ChIP-Seq_ESCs_Mouse1.19711012
120TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19581135
121CRX_20693478_ChIP-Seq_RETINA_Mouse1.18346493
122STAT3_18555785_Chip-Seq_ESCs_Mouse1.18252329
123RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.16829221
124E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16747247
125IRF8_22096565_ChIP-ChIP_GC-B_Human1.15665351
126PIAS1_25552417_ChIP-Seq_VCAP_Human1.15481198
127TCF4_23295773_ChIP-Seq_U87_Human1.15479692
128VDR_21846776_ChIP-Seq_THP-1_Human1.15168612
129FOXA1_25329375_ChIP-Seq_VCAP_Human1.14925204
130FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14925204
131SUZ12_18555785_Chip-Seq_ESCs_Mouse1.14577792
132FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13750573
133E2F1_18555785_Chip-Seq_ESCs_Mouse1.13011216
134NANOG_18555785_ChIP-Seq_MESCs_Mouse1.12746227
135SMAD3_21741376_ChIP-Seq_EPCs_Human1.11849906
136TCF4_22108803_ChIP-Seq_LS180_Human1.11711288
137KDM5A_27292631_Chip-Seq_BREAST_Human1.11205134
138P300_18555785_Chip-Seq_ESCs_Mouse1.10442923
139CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09964334
140CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07741864
141KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07255339
142RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07102182
143EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06064682
144CMYC_18555785_Chip-Seq_ESCs_Mouse1.05258306
145STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05133234
146FLI1_21867929_ChIP-Seq_TH2_Mouse1.04453282
147PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03440509
148POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03042244
149RUNX2_22187159_ChIP-Seq_PCA_Human1.02804081
150MYB_26560356_Chip-Seq_TH2_Human1.01992524
151SOX2_18555785_Chip-Seq_ESCs_Mouse1.01872575
152NCOR_22424771_ChIP-Seq_293T_Human1.00325195
153EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98832292
154OCT4_18555785_Chip-Seq_ESCs_Mouse0.98642498
155AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98127665
156ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97942107
157AR_20517297_ChIP-Seq_VCAP_Human0.97411888
158CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90439716
159MYB_21317192_ChIP-Seq_ERMYB_Mouse0.89939409
160CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.89922564
161RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87378515
162TFEB_21752829_ChIP-Seq_HELA_Human0.83613530
163MYB_26560356_Chip-Seq_TH1_Human0.83572171
164RUNX1_22412390_ChIP-Seq_EML_Mouse0.82294730
165IRF1_19129219_ChIP-ChIP_H3396_Human0.81093268
166MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.80966040
167KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.80186239
168FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77967411
169SOX2_18555785_ChIP-Seq_MESCs_Mouse0.76258892
170GATA1_22383799_ChIP-Seq_G1ME_Mouse0.72527573
171CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.72460476
172MAF_26560356_Chip-Seq_TH1_Human0.72003852
173VDR_24763502_ChIP-Seq_THP-1_Human0.71525614
174FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.71371104
175ELK1_22589737_ChIP-Seq_MCF10A_Human0.71225213
176PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.70772435

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.05861590
2MP0008057_abnormal_DNA_replication3.70995263
3MP0003693_abnormal_embryo_hatching3.70953421
4MP0008058_abnormal_DNA_repair3.39404275
5MP0000569_abnormal_digit_pigmentation3.29476380
6MP0003111_abnormal_nucleus_morphology3.23195948
7MP0003077_abnormal_cell_cycle3.07337360
8MP0004957_abnormal_blastocyst_morpholog2.93502910
9MP0002396_abnormal_hematopoietic_system2.87907796
10MP0003195_calcinosis2.77508447
11MP0008007_abnormal_cellular_replicative2.73839232
12MP0005174_abnormal_tail_pigmentation2.48978223
13MP0001835_abnormal_antigen_presentation2.29780232
14MP0006292_abnormal_olfactory_placode2.25350123
15MP0002735_abnormal_chemical_nociception2.24438203
16MP0000490_abnormal_crypts_of2.22557233
17MP0003880_abnormal_central_pattern2.19561533
18MP0003763_abnormal_thymus_physiology2.16512357
19MP0009046_muscle_twitch2.07704906
20MP0005551_abnormal_eye_electrophysiolog2.06008850
21MP0000015_abnormal_ear_pigmentation2.04247741
22MP0004808_abnormal_hematopoietic_stem1.97218826
23MP0008932_abnormal_embryonic_tissue1.96714954
24MP0004147_increased_porphyrin_level1.92126961
25MP0008877_abnormal_DNA_methylation1.91438024
26MP0005671_abnormal_response_to1.89168839
27MP0001188_hyperpigmentation1.88786305
28MP0005253_abnormal_eye_physiology1.84589164
29MP0001968_abnormal_touch/_nociception1.84331202
30MP0000427_abnormal_hair_cycle1.83049244
31MP0002398_abnormal_bone_marrow1.82235221
32MP0001529_abnormal_vocalization1.82186789
33MP0005075_abnormal_melanosome_morpholog1.81669224
34MP0003136_yellow_coat_color1.81009600
35MP0006072_abnormal_retinal_apoptosis1.80658162
36MP0005171_absent_coat_pigmentation1.79910532
37MP0002095_abnormal_skin_pigmentation1.77968255
38MP0005409_darkened_coat_color1.76231327
39MP0003786_premature_aging1.74275691
40MP0002736_abnormal_nociception_after1.73482974
41MP0001800_abnormal_humoral_immune1.71259380
42MP0002102_abnormal_ear_morphology1.71136576
43MP0008872_abnormal_physiological_respon1.67075798
44MP0006276_abnormal_autonomic_nervous1.65692446
45MP0005646_abnormal_pituitary_gland1.63872306
46MP0009785_altered_susceptibility_to1.62290356
47MP0009333_abnormal_splenocyte_physiolog1.61297913
48MP0002837_dystrophic_cardiac_calcinosis1.60179683
49MP0005379_endocrine/exocrine_gland_phen1.58921311
50MP0004133_heterotaxia1.58123807
51MP0009745_abnormal_behavioral_response1.53937191
52MP0002420_abnormal_adaptive_immunity1.53399206
53MP0000703_abnormal_thymus_morphology1.53073469
54MP0000689_abnormal_spleen_morphology1.52269418
55MP0001819_abnormal_immune_cell1.51548836
56MP0004381_abnormal_hair_follicle1.51079903
57MP0002452_abnormal_antigen_presenting1.50572728
58MP0005645_abnormal_hypothalamus_physiol1.50340841
59MP0002722_abnormal_immune_system1.50330736
60MP0000685_abnormal_immune_system1.49127389
61MP0000716_abnormal_immune_system1.45141079
62MP0002132_abnormal_respiratory_system1.44972468
63MP0009379_abnormal_foot_pigmentation1.44870744
64MP0002272_abnormal_nervous_system1.42469477
65MP0002723_abnormal_immune_serum1.41643236
66MP0000350_abnormal_cell_proliferation1.40185371
67MP0002019_abnormal_tumor_incidence1.37890856
68MP0002429_abnormal_blood_cell1.37502552
69MP0005025_abnormal_response_to1.36247219
70MP0010386_abnormal_urinary_bladder1.34218835
71MP0002148_abnormal_hypersensitivity_rea1.32548161
72MP0005000_abnormal_immune_tolerance1.31834851
73MP0002638_abnormal_pupillary_reflex1.31809234
74MP0009697_abnormal_copulation1.30983675
75MP0001984_abnormal_olfaction1.30605997
76MP0004142_abnormal_muscle_tone1.28950945
77MP0000313_abnormal_cell_death1.28038000
78MP0003315_abnormal_perineum_morphology1.27302306
79MP0001485_abnormal_pinna_reflex1.26775999
80MP0000465_gastrointestinal_hemorrhage1.25699276
81MP0003283_abnormal_digestive_organ1.25522104
82MP0005084_abnormal_gallbladder_morpholo1.19631789
83MP0002751_abnormal_autonomic_nervous1.18722173
84MP0000631_abnormal_neuroendocrine_gland1.18665197
85MP0002734_abnormal_mechanical_nocicepti1.16944620
86MP0004924_abnormal_behavior1.16675420
87MP0005386_behavior/neurological_phenoty1.16675420
88MP0005397_hematopoietic_system_phenotyp1.16171471
89MP0001545_abnormal_hematopoietic_system1.16171471
90MP0003806_abnormal_nucleotide_metabolis1.15961658
91MP0002163_abnormal_gland_morphology1.15297313
92MP0002572_abnormal_emotion/affect_behav1.14458390
93MP0005389_reproductive_system_phenotype1.13903370
94MP0005387_immune_system_phenotype1.13525503
95MP0001790_abnormal_immune_system1.13525503
96MP0003121_genomic_imprinting1.12974138
97MP0000372_irregular_coat_pigmentation1.12886090
98MP0010307_abnormal_tumor_latency1.12626882
99MP0002234_abnormal_pharynx_morphology1.11815449
100MP0002557_abnormal_social/conspecific_i1.11801499
101MP0006036_abnormal_mitochondrial_physio1.11220559
102MP0001486_abnormal_startle_reflex1.11127030
103MP0002733_abnormal_thermal_nociception1.10099737
104MP0004043_abnormal_pH_regulation1.09915372
105MP0002210_abnormal_sex_determination1.09318225
106MP0001986_abnormal_taste_sensitivity1.08233458
107MP0003011_delayed_dark_adaptation1.05809687
108MP0000371_diluted_coat_color1.05467419
109MP0002405_respiratory_system_inflammati1.03816194
110MP0003724_increased_susceptibility_to1.03352850
111MP0000647_abnormal_sebaceous_gland1.03226668
112MP0010155_abnormal_intestine_physiology1.02711645
113MP0002419_abnormal_innate_immunity1.02258415
114MP0001853_heart_inflammation1.01242307
115MP0003718_maternal_effect1.00353146
116MP0002909_abnormal_adrenal_gland0.99783369
117MP0001970_abnormal_pain_threshold0.99174794
118MP0002064_seizures0.98356357
119MP0008961_abnormal_basal_metabolism0.98353334
120MP0005332_abnormal_amino_acid0.97744096
121MP0003436_decreased_susceptibility_to0.96627593
122MP0002006_tumorigenesis0.96218998
123MP0002090_abnormal_vision0.95407680
124MP0002938_white_spotting0.95376695
125MP0001873_stomach_inflammation0.93793285
126MP0003123_paternal_imprinting0.92592808
127MP0002067_abnormal_sensory_capabilities0.92335685
128MP0002075_abnormal_coat/hair_pigmentati0.91429699
129MP0001764_abnormal_homeostasis0.88355040
130MP0001730_embryonic_growth_arrest0.88246498
131MP0002876_abnormal_thyroid_physiology0.87991698
132MP0001324_abnormal_eye_pigmentation0.87808358
133MP0002928_abnormal_bile_duct0.87175315
134MP0008789_abnormal_olfactory_epithelium0.86885289
135MP0001929_abnormal_gametogenesis0.86063357
136MP0001145_abnormal_male_reproductive0.85414786
137MP0001186_pigmentation_phenotype0.84994257
138MP0006035_abnormal_mitochondrial_morpho0.84873374
139MP0001119_abnormal_female_reproductive0.84776201
140MP0003567_abnormal_fetal_cardiomyocyte0.84640044
141MP0008875_abnormal_xenobiotic_pharmacok0.84600900
142MP0001501_abnormal_sleep_pattern0.84206789
143MP0002166_altered_tumor_susceptibility0.84006131
144MP0002277_abnormal_respiratory_mucosa0.81810063
145MP0000858_altered_metastatic_potential0.80994902
146MP0001697_abnormal_embryo_size0.80343740
147MP0004885_abnormal_endolymph0.79875873
148MP0003890_abnormal_embryonic-extraembry0.79869890
149MP0003698_abnormal_male_reproductive0.79788154
150MP0002080_prenatal_lethality0.79786207
151MP0005380_embryogenesis_phenotype0.79336967
152MP0001672_abnormal_embryogenesis/_devel0.79336967
153MP0005448_abnormal_energy_balance0.76923003
154MP0000653_abnormal_sex_gland0.76881115
155MP0001905_abnormal_dopamine_level0.76737906
156MP0000778_abnormal_nervous_system0.75066305
157MP0002009_preneoplasia0.74083179
158MP0005464_abnormal_platelet_physiology0.73177960
159MP0002063_abnormal_learning/memory/cond0.72885833
160MP0003787_abnormal_imprinting0.72871045
161MP0002085_abnormal_embryonic_tissue0.72305751
162MP0005195_abnormal_posterior_eye0.71943521
163MP0000516_abnormal_urinary_system0.71636746
164MP0001919_abnormal_reproductive_system0.69430282
165MP0003866_abnormal_defecation0.67988905
166MP0003984_embryonic_growth_retardation0.67553761
167MP0002088_abnormal_embryonic_growth/wei0.65172949
168MP0008995_early_reproductive_senescence0.64744824
169MP0002177_abnormal_outer_ear0.64360937
170MP0002160_abnormal_reproductive_system0.64160327
171MP0001293_anophthalmia0.63851655
172MP0003943_abnormal_hepatobiliary_system0.63175814

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.43661829
2Chromsome breakage (HP:0040012)4.39379791
3Reticulocytopenia (HP:0001896)4.17698833
4Birth length less than 3rd percentile (HP:0003561)3.90038056
5Pancreatic cysts (HP:0001737)3.77629919
6Abnormality of cells of the erythroid lineage (HP:0012130)3.76656753
7Abnormal number of erythroid precursors (HP:0012131)3.72365457
8Abnormality of chromosome stability (HP:0003220)3.35184959
9Abnormality of midbrain morphology (HP:0002418)3.31525980
10Molar tooth sign on MRI (HP:0002419)3.31525980
11Aplastic anemia (HP:0001915)3.25032109
12Pancreatic fibrosis (HP:0100732)3.22808128
13Abnormality of the preputium (HP:0100587)3.21331584
14Type I transferrin isoform profile (HP:0003642)3.15228394
15Abnormality of the ileum (HP:0001549)3.12137075
16Aplasia/Hypoplasia of the uvula (HP:0010293)3.10954962
17Meckel diverticulum (HP:0002245)3.10875895
18True hermaphroditism (HP:0010459)3.10695405
19Hyperventilation (HP:0002883)3.07906475
20Acute necrotizing encephalopathy (HP:0006965)2.98026965
21IgM deficiency (HP:0002850)2.97883238
22Nephronophthisis (HP:0000090)2.86496722
23Increased CSF lactate (HP:0002490)2.84990334
24Progressive macrocephaly (HP:0004481)2.82844346
25Pallor (HP:0000980)2.80425907
26Medial flaring of the eyebrow (HP:0010747)2.80056149
27Renal cortical cysts (HP:0000803)2.77595504
28Abnormality of the renal cortex (HP:0011035)2.76824892
29Mitochondrial inheritance (HP:0001427)2.76201537
30Clubbing of toes (HP:0100760)2.74596106
31Congenital stationary night blindness (HP:0007642)2.74444881
32Increased hepatocellular lipid droplets (HP:0006565)2.69949542
33Lipid accumulation in hepatocytes (HP:0006561)2.69005540
34Hypothermia (HP:0002045)2.67665144
35Medulloblastoma (HP:0002885)2.67042979
36Myelodysplasia (HP:0002863)2.65876043
37Acute encephalopathy (HP:0006846)2.59608914
38Patellar aplasia (HP:0006443)2.58902566
39Abnormality of DNA repair (HP:0003254)2.58564009
40Bone marrow hypocellularity (HP:0005528)2.56251729
41Duodenal stenosis (HP:0100867)2.55988447
42Small intestinal stenosis (HP:0012848)2.55988447
43Thrombocytosis (HP:0001894)2.52045009
44Abolished electroretinogram (ERG) (HP:0000550)2.47105956
45Abnormal mitochondria in muscle tissue (HP:0008316)2.45978825
46B lymphocytopenia (HP:0010976)2.44889445
47Abnormality of B cell number (HP:0010975)2.44889445
48Abnormal lung lobation (HP:0002101)2.44551974
49Abnormality of the renal medulla (HP:0100957)2.42970795
50Abnormality of the carotid arteries (HP:0005344)2.41258722
51Volvulus (HP:0002580)2.41241384
52Hyperalaninemia (HP:0003348)2.41102271
53Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.41102271
54Abnormality of alanine metabolism (HP:0010916)2.41102271
55Attenuation of retinal blood vessels (HP:0007843)2.41024137
56Aplasia/Hypoplasia of the patella (HP:0006498)2.40724445
57Oral leukoplakia (HP:0002745)2.40589680
58Gaze-evoked nystagmus (HP:0000640)2.39942053
59Renal Fanconi syndrome (HP:0001994)2.39091985
60Reduced antithrombin III activity (HP:0001976)2.38742080
61Nephroblastoma (Wilms tumor) (HP:0002667)2.38697993
62Agnosia (HP:0010524)2.38094781
63Methylmalonic acidemia (HP:0002912)2.37430946
64Macrocytic anemia (HP:0001972)2.37357140
65Absent thumb (HP:0009777)2.36749716
66Pendular nystagmus (HP:0012043)2.36639779
67Duplicated collecting system (HP:0000081)2.36144632
68Progressive inability to walk (HP:0002505)2.34463347
69Nephrogenic diabetes insipidus (HP:0009806)2.30975410
70Chronic otitis media (HP:0000389)2.30441496
71Lymphoma (HP:0002665)2.27969114
72Abnormal protein glycosylation (HP:0012346)2.27787971
73Abnormal glycosylation (HP:0012345)2.27787971
74Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.27787971
75Abnormal protein N-linked glycosylation (HP:0012347)2.27787971
76Lissencephaly (HP:0001339)2.23159005
77Triphalangeal thumb (HP:0001199)2.23117424
78Gait imbalance (HP:0002141)2.22616003
79Congenital primary aphakia (HP:0007707)2.22363251
80Abnormality of the renal collecting system (HP:0004742)2.21837784
81Acute lymphatic leukemia (HP:0006721)2.20744743
82Panhypogammaglobulinemia (HP:0003139)2.19688185
83Type 2 muscle fiber atrophy (HP:0003554)2.19420488
84Abnormality of T cell physiology (HP:0011840)2.19173635
85Premature graying of hair (HP:0002216)2.19003610
86Hepatic necrosis (HP:0002605)2.18811526
87Embryonal renal neoplasm (HP:0011794)2.18461019
88Abnormal number of incisors (HP:0011064)2.18195330
89Agammaglobulinemia (HP:0004432)2.17663089
90Hepatocellular necrosis (HP:0001404)2.17214909
91Abnormality of the labia minora (HP:0012880)2.16078435
92Intestinal atresia (HP:0011100)2.16016283
93IgG deficiency (HP:0004315)2.14749325
94Muscle fiber atrophy (HP:0100295)2.13579532
95Chronic hepatic failure (HP:0100626)2.11107009
96Optic disc pallor (HP:0000543)2.10284033
97Supernumerary spleens (HP:0009799)2.08504251
98Meningitis (HP:0001287)2.07021154
99Recurrent viral infections (HP:0004429)2.06434772
100Amaurosis fugax (HP:0100576)2.06380298
101Bile duct proliferation (HP:0001408)2.06271027
102Abnormal biliary tract physiology (HP:0012439)2.06271027
103Sloping forehead (HP:0000340)2.06229375
104Type II lissencephaly (HP:0007260)2.06185499
105Large for gestational age (HP:0001520)2.05155444
106Hypoplasia of the fovea (HP:0007750)2.04985610
107Aplasia/Hypoplasia of the fovea (HP:0008060)2.04985610
108Increased serum lactate (HP:0002151)2.04508857
109Myositis (HP:0100614)2.03091153
110Sclerocornea (HP:0000647)2.02197438
111Aplasia/Hypoplasia of the sacrum (HP:0008517)2.00882446
112Methylmalonic aciduria (HP:0012120)2.00866468
11311 pairs of ribs (HP:0000878)2.00096299
114Abnormality of T cells (HP:0002843)1.99838590
115Pancytopenia (HP:0001876)1.99500449
116Increased nuchal translucency (HP:0010880)1.99485232
117Aplasia/Hypoplasia of the tibia (HP:0005772)1.99359419
118Selective tooth agenesis (HP:0001592)1.99344167
119Abnormality of the duodenum (HP:0002246)1.96515215
120Optic nerve coloboma (HP:0000588)1.96449345
121Tracheoesophageal fistula (HP:0002575)1.95838830
122Breast hypoplasia (HP:0003187)1.95549573
123Petechiae (HP:0000967)1.94350981
124Aplasia/Hypoplasia of the tongue (HP:0010295)1.93256058
125Pulmonary fibrosis (HP:0002206)1.92930921
126Ectopic kidney (HP:0000086)1.92718719
127Cerebral edema (HP:0002181)1.91630680
128Recurrent bronchitis (HP:0002837)1.91565984
129Genital tract atresia (HP:0001827)1.90467548
130Short thumb (HP:0009778)1.89697504
131Congenital, generalized hypertrichosis (HP:0004540)1.89495889
132Abnormality of the prostate (HP:0008775)1.89428053
133Colon cancer (HP:0003003)1.89024243
134Respiratory difficulties (HP:0002880)1.88879015
135Thyroiditis (HP:0100646)1.88466907
136Elevated erythrocyte sedimentation rate (HP:0003565)1.88052602
137Polydipsia (HP:0001959)1.87976020
138Abnormal drinking behavior (HP:0030082)1.87976020
139Abnormal delayed hypersensitivity skin test (HP:0002963)1.87042141
140Inability to walk (HP:0002540)1.86815574
141Albinism (HP:0001022)1.86345390
142Ketoacidosis (HP:0001993)1.86216416
143Exertional dyspnea (HP:0002875)1.86207984
144Abnormality of the fovea (HP:0000493)1.84677536
145Furrowed tongue (HP:0000221)1.84609978
146Obstructive lung disease (HP:0006536)1.84244022
147Chronic obstructive pulmonary disease (HP:0006510)1.84244022
148Abnormal rod and cone electroretinograms (HP:0008323)1.83977142
149Abnormality of macular pigmentation (HP:0008002)1.83774030
150Leukopenia (HP:0001882)1.83515736
151Rough bone trabeculation (HP:0100670)1.83513079
152Microretrognathia (HP:0000308)1.83320845
153Broad-based gait (HP:0002136)1.83091604
154Poor head control (HP:0002421)1.82405092
155Tubular atrophy (HP:0000092)1.82095784
156Recurrent abscess formation (HP:0002722)1.82054301
157Severe visual impairment (HP:0001141)1.81688539
158Cellular immunodeficiency (HP:0005374)1.81355363
159Poikiloderma (HP:0001029)1.80026121
160Cleft eyelid (HP:0000625)1.79602212
161Vaginal atresia (HP:0000148)1.79236625
162Absent rod-and cone-mediated responses on ERG (HP:0007688)1.79056154
1633-Methylglutaconic aciduria (HP:0003535)1.78291051
164Abnormality of vitamin B metabolism (HP:0004340)1.77651847
165Glycosuria (HP:0003076)1.76880655
166Abnormality of urine glucose concentration (HP:0011016)1.76880655
167Abnormality of the columella (HP:0009929)1.74932813
168Fair hair (HP:0002286)1.74836292
169Small hand (HP:0200055)1.74025494
170Cystic liver disease (HP:0006706)1.73722314
171Hypoplasia of the radius (HP:0002984)1.73288332
172Abnormality of the pons (HP:0007361)1.72842576
173Neoplasm of the pancreas (HP:0002894)1.72080392
174Mediastinal lymphadenopathy (HP:0100721)1.71038456
175Proximal placement of thumb (HP:0009623)1.70978183
176Lethargy (HP:0001254)1.70239864
177Lactic acidosis (HP:0003128)1.70070085
178Postaxial foot polydactyly (HP:0001830)1.70063056
179Anencephaly (HP:0002323)1.69778129
180Congenital sensorineural hearing impairment (HP:0008527)1.69063588
181Male pseudohermaphroditism (HP:0000037)1.68991377
182Congenital hepatic fibrosis (HP:0002612)1.64922495
183Astigmatism (HP:0000483)1.63272346

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM284.87417562
2FRK4.53797271
3CDC73.51775533
4WEE13.50955960
5PASK3.21542951
6BUB13.02263009
7WNK33.00138848
8MAP4K22.80818723
9STK162.80305602
10BRSK22.58858398
11MKNK22.54303700
12MKNK12.50928128
13SRPK12.35401419
14VRK12.16217726
15CCNB12.13214398
16EIF2AK32.12095877
17PLK42.10191049
18NME22.03153118
19EIF2AK11.97328444
20BMPR1B1.94352184
21IRAK41.92875268
22ACVR1B1.88960680
23GRK11.88853997
24TEC1.81550155
25NEK21.80673642
26BCR1.74647266
27MAP3K41.74148200
28TLK11.71891703
29DYRK31.69474599
30INSRR1.68159335
31OXSR11.66949872
32ATR1.63267167
33CLK11.56467685
34YES11.55231896
35MAP4K11.54797265
36STK391.54504708
37KIT1.51873300
38FER1.44592597
39TNIK1.43532047
40PLK11.43387763
41TXK1.40534067
42BRSK11.40330784
43BTK1.39585990
44CDK41.34276411
45PNCK1.34204617
46CDK71.30169939
47CASK1.30104971
48PLK21.27548192
49EIF2AK21.24759323
50AURKB1.23849657
51CDK81.20359436
52TTK1.19430430
53BLK1.14884246
54CSNK1G31.13517358
55TSSK61.09070872
56PAK31.08495953
57CSNK1G21.07699902
58CHEK21.05157512
59SIK31.04482280
60FLT31.04311771
61TESK21.04246563
62TGFBR11.01584202
63CSNK1G11.01424938
64CSNK1A1L1.01298668
65ZAK0.99198024
66PRKCE0.98543561
67NLK0.98113653
68PIM20.97257522
69PLK30.96622952
70MAP2K60.96207035
71MUSK0.95939719
72WNK40.91896802
73RPS6KA40.91495257
74EPHA40.88886141
75TAOK30.88341883
76PINK10.86695428
77NTRK30.86638965
78SCYL20.85652903
79CSF1R0.84810250
80NUAK10.83783648
81SYK0.83624313
82NEK10.83201962
83STK38L0.82621703
84PIM10.79116291
85CHEK10.77855213
86RPS6KB20.77359230
87DAPK20.76945661
88VRK20.76288230
89NME10.75998455
90MARK10.75984766
91BCKDK0.75926972
92EPHA30.73541861
93STK100.72867200
94ZAP700.72544170
95PRKCG0.72529571
96LYN0.72067406
97AURKA0.71847798
98PAK40.71566401
99MARK30.71326553
100STK30.70301956
101STK40.68919555
102MAPK130.64674952
103PBK0.64501902
104ATM0.63482046
105BRD40.63203761
106MST40.62140727
107IKBKB0.60591326
108CSNK2A10.59934897
109FGFR20.58607274
110ADRBK10.58465389
111MAP3K120.56701820
112CDK190.54686440
113CDK90.54632951
114DYRK20.54326984
115CDK30.54316329
116MAP3K100.53272037
117EEF2K0.52826311
118TAF10.52486155
119IRAK20.52480973
120IKBKE0.51888133
121JAK30.51806406
122MAP3K80.51207925
123CAMKK20.49183880
124LCK0.48818718
125CDK20.47258186
126CSNK2A20.46698943
127KDR0.46630689
128FES0.46133333
129IRAK10.45910775
130PRKCI0.44716812
131MATK0.43288249
132RPS6KA50.42859058
133MAP3K60.41741410
134PHKG20.40999819
135PHKG10.40999819
136IRAK30.40054401
137CSNK1A10.39940254
138MINK10.39492403
139CAMK2A0.39399778
140GRK60.38032960
141PKN10.37110491
142ADRBK20.35659302
143ERBB30.35451523
144TAOK20.35103931
145CHUK0.34876082
146GRK70.34498053
147PAK10.34010862
148BMPR20.33745411
149KSR10.33640433
150MAPK40.33481486
151TNK20.33045665
152CDK10.32932231
153MAP3K50.32397843
154MAP2K70.32036072
155PRKACA0.30979169
156PRKCQ0.29781951
157PRKACB0.29055899
158CSNK1D0.28484366

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.14556497
2Mismatch repair_Homo sapiens_hsa034304.05389727
3Ribosome_Homo sapiens_hsa030103.39040619
4Homologous recombination_Homo sapiens_hsa034403.35781057
5Base excision repair_Homo sapiens_hsa034103.17151764
6Oxidative phosphorylation_Homo sapiens_hsa001903.06312863
7Spliceosome_Homo sapiens_hsa030402.90238305
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.73716716
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.66976623
10Fanconi anemia pathway_Homo sapiens_hsa034602.63964287
11RNA polymerase_Homo sapiens_hsa030202.57347847
12Nucleotide excision repair_Homo sapiens_hsa034202.55801188
13Butanoate metabolism_Homo sapiens_hsa006502.51219379
14Phototransduction_Homo sapiens_hsa047442.39861009
15Cell cycle_Homo sapiens_hsa041102.39833852
16Proteasome_Homo sapiens_hsa030502.37660866
17Non-homologous end-joining_Homo sapiens_hsa034502.35512723
18Pyrimidine metabolism_Homo sapiens_hsa002402.28811707
19Maturity onset diabetes of the young_Homo sapiens_hsa049502.17860056
20RNA transport_Homo sapiens_hsa030132.06682612
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.93027856
22Basal transcription factors_Homo sapiens_hsa030221.90959989
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.90670112
24Primary immunodeficiency_Homo sapiens_hsa053401.72226339
25RNA degradation_Homo sapiens_hsa030181.70591001
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.67533003
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.65054029
28Propanoate metabolism_Homo sapiens_hsa006401.62268089
29One carbon pool by folate_Homo sapiens_hsa006701.61345152
30Alzheimers disease_Homo sapiens_hsa050101.51217160
31Caffeine metabolism_Homo sapiens_hsa002321.49935910
32Nicotine addiction_Homo sapiens_hsa050331.49545269
33p53 signaling pathway_Homo sapiens_hsa041151.44011951
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.41719914
35Linoleic acid metabolism_Homo sapiens_hsa005911.39151788
36Peroxisome_Homo sapiens_hsa041461.33881848
37Purine metabolism_Homo sapiens_hsa002301.31605181
38Herpes simplex infection_Homo sapiens_hsa051681.31571462
39Histidine metabolism_Homo sapiens_hsa003401.28410437
40Nitrogen metabolism_Homo sapiens_hsa009101.27011686
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.26562186
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.25202923
43Selenocompound metabolism_Homo sapiens_hsa004501.25169561
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.23776647
45Collecting duct acid secretion_Homo sapiens_hsa049661.22926196
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.22211003
47Intestinal immune network for IgA production_Homo sapiens_hsa046721.20635087
48mRNA surveillance pathway_Homo sapiens_hsa030151.20381723
49Primary bile acid biosynthesis_Homo sapiens_hsa001201.20166623
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19514600
51Epstein-Barr virus infection_Homo sapiens_hsa051691.15180528
52Ether lipid metabolism_Homo sapiens_hsa005651.12287889
53NF-kappa B signaling pathway_Homo sapiens_hsa040641.06954432
54Tryptophan metabolism_Homo sapiens_hsa003801.06853239
55Antigen processing and presentation_Homo sapiens_hsa046121.06730906
56Systemic lupus erythematosus_Homo sapiens_hsa053221.05289060
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.05133003
58Measles_Homo sapiens_hsa051621.01509673
59Fatty acid elongation_Homo sapiens_hsa000621.00981143
60Sulfur metabolism_Homo sapiens_hsa009200.97165423
61Steroid biosynthesis_Homo sapiens_hsa001000.96072202
62Protein export_Homo sapiens_hsa030600.95546022
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93742523
64Regulation of autophagy_Homo sapiens_hsa041400.92079414
65Allograft rejection_Homo sapiens_hsa053300.91273647
66Leishmaniasis_Homo sapiens_hsa051400.88242009
67Olfactory transduction_Homo sapiens_hsa047400.87129872
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86589829
69Hematopoietic cell lineage_Homo sapiens_hsa046400.86444380
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.86026430
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85894989
72N-Glycan biosynthesis_Homo sapiens_hsa005100.85816531
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83855423
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81156648
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80021112
76Taste transduction_Homo sapiens_hsa047420.79875023
77Viral carcinogenesis_Homo sapiens_hsa052030.79611458
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77536870
79GABAergic synapse_Homo sapiens_hsa047270.76768565
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.75984873
81HTLV-I infection_Homo sapiens_hsa051660.74537170
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72160986
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.71730902
84Cardiac muscle contraction_Homo sapiens_hsa042600.71550398
85Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.70608849
86Legionellosis_Homo sapiens_hsa051340.70606414
87Metabolic pathways_Homo sapiens_hsa011000.69461242
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67582631
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67111309
90B cell receptor signaling pathway_Homo sapiens_hsa046620.67095620
91Morphine addiction_Homo sapiens_hsa050320.66894356
92Hepatitis B_Homo sapiens_hsa051610.66869578
93Chemical carcinogenesis_Homo sapiens_hsa052040.66007280
94Asthma_Homo sapiens_hsa053100.65464454
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64068167
96Thyroid cancer_Homo sapiens_hsa052160.63965362
97Retinol metabolism_Homo sapiens_hsa008300.61694539
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60050145
99Oocyte meiosis_Homo sapiens_hsa041140.60014878
100Shigellosis_Homo sapiens_hsa051310.57459874
101Apoptosis_Homo sapiens_hsa042100.56794039
102Dopaminergic synapse_Homo sapiens_hsa047280.55936919
103Influenza A_Homo sapiens_hsa051640.54909582
104beta-Alanine metabolism_Homo sapiens_hsa004100.54463232
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54388836
106Toll-like receptor signaling pathway_Homo sapiens_hsa046200.54176308
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53813509
108Graft-versus-host disease_Homo sapiens_hsa053320.52888057
109Circadian entrainment_Homo sapiens_hsa047130.52794728
110T cell receptor signaling pathway_Homo sapiens_hsa046600.52413479
111Cysteine and methionine metabolism_Homo sapiens_hsa002700.51844456
112Insulin secretion_Homo sapiens_hsa049110.51379655
113MicroRNAs in cancer_Homo sapiens_hsa052060.51331683
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51001205
115Colorectal cancer_Homo sapiens_hsa052100.50828895
116Autoimmune thyroid disease_Homo sapiens_hsa053200.49886512
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.49297074
118Type I diabetes mellitus_Homo sapiens_hsa049400.48668819
119Notch signaling pathway_Homo sapiens_hsa043300.47556932
120Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.47409167
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46288107
122Other glycan degradation_Homo sapiens_hsa005110.45496646
123Huntingtons disease_Homo sapiens_hsa050160.45493375
124Viral myocarditis_Homo sapiens_hsa054160.44985493
125Small cell lung cancer_Homo sapiens_hsa052220.44517608
126Acute myeloid leukemia_Homo sapiens_hsa052210.44047095
127Pertussis_Homo sapiens_hsa051330.43959958
128ABC transporters_Homo sapiens_hsa020100.42795299
129Alcoholism_Homo sapiens_hsa050340.42693356
130Circadian rhythm_Homo sapiens_hsa047100.42348816
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42123633
132Fatty acid metabolism_Homo sapiens_hsa012120.41159892
133Renin-angiotensin system_Homo sapiens_hsa046140.40866809
134Amphetamine addiction_Homo sapiens_hsa050310.39549843
135Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38739240
136Serotonergic synapse_Homo sapiens_hsa047260.38694628
137Glutamatergic synapse_Homo sapiens_hsa047240.38619419
138Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37835775
139Osteoclast differentiation_Homo sapiens_hsa043800.37018670
140Pentose phosphate pathway_Homo sapiens_hsa000300.36315707
141Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35843464
142Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35621071
143Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34912257
144SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34179713
145Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32689889
146Toxoplasmosis_Homo sapiens_hsa051450.31440768
147Parkinsons disease_Homo sapiens_hsa050120.31311377
148Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29994258
149Pancreatic cancer_Homo sapiens_hsa052120.29272237
150Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.29004240
151Chronic myeloid leukemia_Homo sapiens_hsa052200.28359266
152Arachidonic acid metabolism_Homo sapiens_hsa005900.28131153
153Pathways in cancer_Homo sapiens_hsa052000.27576695
154Malaria_Homo sapiens_hsa051440.26450304
155Sulfur relay system_Homo sapiens_hsa041220.25492935
156Tuberculosis_Homo sapiens_hsa051520.25370062
157Basal cell carcinoma_Homo sapiens_hsa052170.24922227
158TNF signaling pathway_Homo sapiens_hsa046680.23595929
159Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.23342433
160Salmonella infection_Homo sapiens_hsa051320.22814298
161Folate biosynthesis_Homo sapiens_hsa007900.22622466
162Glycosaminoglycan degradation_Homo sapiens_hsa005310.21643495
163Non-small cell lung cancer_Homo sapiens_hsa052230.18841133

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