INHBC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of homodimeric and heterodimeric activin complexes. The heterodimeric complex may function in the inhibition of activin A signaling. Transgenic mice overexpressing this gene exhibit defects in testis, liver and prostate. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)8.14099004
2epoxygenase P450 pathway (GO:0019373)7.77422662
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.61374495
4L-phenylalanine catabolic process (GO:0006559)7.61374495
5omega-hydroxylase P450 pathway (GO:0097267)7.40011432
6L-phenylalanine metabolic process (GO:0006558)7.28404774
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.28404774
8aromatic amino acid family catabolic process (GO:0009074)6.89855840
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.39191311
10tryptophan catabolic process (GO:0006569)6.27838197
11indole-containing compound catabolic process (GO:0042436)6.27838197
12indolalkylamine catabolic process (GO:0046218)6.27838197
13kynurenine metabolic process (GO:0070189)6.15714849
14bile acid biosynthetic process (GO:0006699)6.04938355
15tryptophan metabolic process (GO:0006568)5.89015886
16glyoxylate metabolic process (GO:0046487)5.86391618
17drug metabolic process (GO:0017144)5.72904468
18negative regulation of fibrinolysis (GO:0051918)5.70086652
19alpha-linolenic acid metabolic process (GO:0036109)5.66514128
20high-density lipoprotein particle remodeling (GO:0034375)5.65324446
21oxidative demethylation (GO:0070989)5.64446391
22urea metabolic process (GO:0019627)5.62873745
23urea cycle (GO:0000050)5.62873745
24regulation of fibrinolysis (GO:0051917)5.51429140
25complement activation, alternative pathway (GO:0006957)5.50787928
26regulation of protein activation cascade (GO:2000257)5.47658174
27peptidyl-glutamic acid carboxylation (GO:0017187)5.45759288
28protein carboxylation (GO:0018214)5.45759288
29regulation of plasminogen activation (GO:0010755)5.38420625
30sulfur amino acid catabolic process (GO:0000098)5.31907300
31cysteine metabolic process (GO:0006534)5.29257078
32nitrogen cycle metabolic process (GO:0071941)5.17645327
33phenylpropanoid metabolic process (GO:0009698)5.14566199
34bile acid metabolic process (GO:0008206)5.14247770
35regulation of complement activation (GO:0030449)5.13098806
36serine family amino acid catabolic process (GO:0009071)5.12027703
37negative regulation of blood coagulation (GO:0030195)5.09635471
38negative regulation of hemostasis (GO:1900047)5.09635471
39aromatic amino acid family metabolic process (GO:0009072)5.00921191
40fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.94367245
41reverse cholesterol transport (GO:0043691)4.93686977
42regulation of cholesterol esterification (GO:0010872)4.91757300
43regulation of triglyceride catabolic process (GO:0010896)4.91016887
44ethanol metabolic process (GO:0006067)4.89988196
45tyrosine metabolic process (GO:0006570)4.81707618
46protein-lipid complex remodeling (GO:0034368)4.81417810
47macromolecular complex remodeling (GO:0034367)4.81417810
48plasma lipoprotein particle remodeling (GO:0034369)4.81417810
49acylglycerol homeostasis (GO:0055090)4.67502774
50triglyceride homeostasis (GO:0070328)4.67502774
51homocysteine metabolic process (GO:0050667)4.66946541
52alpha-amino acid catabolic process (GO:1901606)4.63963792
53negative regulation of coagulation (GO:0050819)4.63248333
54phospholipid efflux (GO:0033700)4.62113657
55negative regulation of cholesterol transport (GO:0032375)4.59021438
56negative regulation of sterol transport (GO:0032372)4.59021438
57amino-acid betaine metabolic process (GO:0006577)4.57632566
58negative regulation of wound healing (GO:0061045)4.57441202
59lysine catabolic process (GO:0006554)4.56048117
60lysine metabolic process (GO:0006553)4.56048117
61cellular ketone body metabolic process (GO:0046950)4.54428807
62negative regulation of protein activation cascade (GO:2000258)4.52938214
63regulation of humoral immune response (GO:0002920)4.52580993
64coenzyme catabolic process (GO:0009109)4.48838403
65glycine metabolic process (GO:0006544)4.46256835
66positive regulation of blood coagulation (GO:0030194)4.44239369
67positive regulation of hemostasis (GO:1900048)4.44239369
68indolalkylamine metabolic process (GO:0006586)4.43537265
69bile acid and bile salt transport (GO:0015721)4.41302668
70plasma lipoprotein particle clearance (GO:0034381)4.39771337
71amine catabolic process (GO:0009310)4.35563937
72cellular biogenic amine catabolic process (GO:0042402)4.35563937
73acute-phase response (GO:0006953)4.34795827
74imidazole-containing compound metabolic process (GO:0052803)4.34089629
75cellular amino acid catabolic process (GO:0009063)4.26634958
76cholesterol efflux (GO:0033344)4.24542076
77glutamate metabolic process (GO:0006536)4.24114942
78alkaloid metabolic process (GO:0009820)4.22317598
79cellular glucuronidation (GO:0052695)4.20843902
80serine family amino acid metabolic process (GO:0009069)4.17883029
81benzene-containing compound metabolic process (GO:0042537)4.12970263
82S-adenosylmethionine metabolic process (GO:0046500)4.09932592
83positive regulation of coagulation (GO:0050820)4.09791178
84ethanol oxidation (GO:0006069)4.07942109
85fibrinolysis (GO:0042730)4.07365504
86dicarboxylic acid biosynthetic process (GO:0043650)4.06119865
87cellular modified amino acid catabolic process (GO:0042219)4.05150989
88intestinal cholesterol absorption (GO:0030299)4.03939863
89arginine metabolic process (GO:0006525)4.02468759
90hormone catabolic process (GO:0042447)3.99864742
91plasma lipoprotein particle assembly (GO:0034377)3.99218902
92serine family amino acid biosynthetic process (GO:0009070)3.98968674
93aldehyde catabolic process (GO:0046185)3.97132817
94low-density lipoprotein particle remodeling (GO:0034374)3.96148225
95ketone body metabolic process (GO:1902224)3.93464676
96blood coagulation, intrinsic pathway (GO:0007597)3.91384579
97complement activation, classical pathway (GO:0006958)3.90831368
98cytolysis (GO:0019835)3.88634853
99negative regulation of complement activation (GO:0045916)3.87077756
100positive regulation of triglyceride lipase activity (GO:0061365)3.86443518
101positive regulation of lipoprotein lipase activity (GO:0051006)3.86443518
102heme transport (GO:0015886)3.85826689
103complement activation (GO:0006956)3.83818743
104cofactor catabolic process (GO:0051187)3.83320318
105protein activation cascade (GO:0072376)3.80198677
106drug catabolic process (GO:0042737)3.77397213
107negative regulation of lipase activity (GO:0060192)3.77009947
108regulation of lipoprotein particle clearance (GO:0010984)3.75762111
109cholesterol homeostasis (GO:0042632)3.74272970
110positive regulation of lipid catabolic process (GO:0050996)3.74230054
111carboxylic acid catabolic process (GO:0046395)3.73602798
112organic acid catabolic process (GO:0016054)3.73602798
113uronic acid metabolic process (GO:0006063)3.73309558
114glucuronate metabolic process (GO:0019585)3.73309558
115phospholipid homeostasis (GO:0055091)3.72523607
116regulation of bile acid biosynthetic process (GO:0070857)3.70481787
117very-low-density lipoprotein particle assembly (GO:0034379)3.70418848
118sterol homeostasis (GO:0055092)3.68063442
119acetyl-CoA metabolic process (GO:0006084)3.67372115
120regulation of cholesterol homeostasis (GO:2000188)3.66764184
121plasma lipoprotein particle organization (GO:0071827)3.64698070
122NAD biosynthetic process (GO:0009435)3.62157812
123short-chain fatty acid metabolic process (GO:0046459)3.61092216
124protein-lipid complex assembly (GO:0065005)3.57393594
125nicotinamide nucleotide biosynthetic process (GO:0019359)3.57278487
126fat-soluble vitamin biosynthetic process (GO:0042362)3.55529728
127flavonoid metabolic process (GO:0009812)3.53923401
128positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.48049712
129steroid catabolic process (GO:0006706)3.47684727
130regulation of apoptotic cell clearance (GO:2000425)3.46736918
131opsonization (GO:0008228)3.43513507
132xenobiotic metabolic process (GO:0006805)3.40774768

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.41480113
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.24270737
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.10698070
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.51153595
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.32213995
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.11841371
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.84647792
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.04259875
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.00468765
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.06226546
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.0530806
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.98218561
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95842629
14HTT_18923047_ChIP-ChIP_STHdh_Human1.59502152
15* FOXA2_19822575_ChIP-Seq_HepG2_Human1.58234540
16CLOCK_20551151_ChIP-Seq_293T_Human1.50626307
17GATA1_22025678_ChIP-Seq_K562_Human1.42416911
18* HNF4A_19822575_ChIP-Seq_HepG2_Human1.39449526
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29197211
20RXRA_24833708_ChIP-Seq_LIVER_Mouse1.22657021
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20843252
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16800745
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10355606
24ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05543025
25ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01935565
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00504882
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95970429
28NFE2_27457419_Chip-Seq_LIVER_Mouse0.93592089
29TRIM28_21343339_ChIP-Seq_HEK293_Human0.92021211
30CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.90956104
31HNFA_21074721_ChIP-Seq_CACO-2_Human0.88723014
32* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.87241197
33ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.86499903
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.84985365
35AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82877580
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.82318182
37RARG_19884340_ChIP-ChIP_MEFs_Mouse0.81865338
38IRF8_22096565_ChIP-ChIP_GC-B_Human0.80026428
39ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79614875
40GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.78680289
41PHF8_20622853_ChIP-Seq_HELA_Human0.78263652
42KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77942427
43SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77664559
44GATA4_25053715_ChIP-Seq_YYC3_Human0.77510423
45TCF4_18268006_ChIP-ChIP_LS174T_Human0.76951073
46IRF1_19129219_ChIP-ChIP_H3396_Human0.75707338
47SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.75422558
48RARA_24833708_ChIP-Seq_LIVER_Mouse0.75394439
49BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.73202302
50GATA6_21074721_ChIP-Seq_CACO-2_Human0.72952306
51EZH2_27294783_Chip-Seq_NPCs_Mouse0.71229848
52SOX2_21211035_ChIP-Seq_LN229_Human0.70250917
53CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70232819
54NFYA_21822215_ChIP-Seq_K562_Human0.70005695
55CBX2_22325352_ChIP-Seq_293T-Rex_Human0.69496617
56ZNF263_19887448_ChIP-Seq_K562_Human0.68936342
57Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.68322374
58TP53_18474530_ChIP-ChIP_U2OS_Human0.67874114
59PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.67804943
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.66930101
61SALL4_18804426_ChIP-ChIP_XEN_Mouse0.65846068
62AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.65694488
63RARB_24833708_ChIP-Seq_LIVER_Mouse0.65642502
64ESR2_21235772_ChIP-Seq_MCF-7_Human0.65006733
65SUZ12_27294783_Chip-Seq_NPCs_Mouse0.64874300
66SRY_22984422_ChIP-ChIP_TESTIS_Rat0.63916478
67RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63048445
68NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.62623457
69RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.62040214
70NRF2_20460467_ChIP-Seq_MEFs_Mouse0.61976282
71NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.61976282
72RAC3_21632823_ChIP-Seq_H3396_Human0.61915492
73BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.60799824
74NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.60726758
75SMAD1_18555785_Chip-Seq_ESCs_Mouse0.59829957
76PIAS1_25552417_ChIP-Seq_VCAP_Human0.59238569
77RUNX1_27457419_Chip-Seq_LIVER_Mouse0.59116530
78ETV1_20927104_ChIP-Seq_GIST48_Human0.58711900
79NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.58643238
80ESRRB_18555785_Chip-Seq_ESCs_Mouse0.57101033
81FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.56858565
82CEBPB_22108803_ChIP-Seq_LS180_Human0.56427810
83OCT4_18555785_Chip-Seq_ESCs_Mouse0.56170192
84SOX2_20726797_ChIP-Seq_SW620_Human0.56074143
85EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.54911863
86CRX_20693478_ChIP-Seq_RETINA_Mouse0.54163132
87STAT3_1855785_ChIP-Seq_MESCs_Mouse0.54099916
88LXR_22292898_ChIP-Seq_THP-1_Human0.54051409
89EGR1_19032775_ChIP-ChIP_M12_Human0.53632064
90ETV2_25802403_ChIP-Seq_MESCs_Mouse0.53032871
91PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.52471486
92MYC_19915707_ChIP-ChIP_AK7_Human0.52409808
93PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.52110411
94ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.51835813
95RBPJ_21746931_ChIP-Seq_IB4_Human0.51722582
96AR_20517297_ChIP-Seq_VCAP_Human0.51706500
97FOXA1_25552417_ChIP-Seq_VCAP_Human0.51205356
98SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.51141561
99OCT4_21477851_ChIP-Seq_ESCs_Mouse0.51052454
100E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.50798157
101SPI1_20517297_ChIP-Seq_HL60_Human0.50420810
102FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.50310382
103SMC4_20622854_ChIP-Seq_HELA_Human0.50280080
104POU5F1_16518401_ChIP-PET_MESCs_Mouse0.49786158
105FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.49692050
106ESET_19884257_ChIP-Seq_ESCs_Mouse0.49620413
107PU1_27457419_Chip-Seq_LIVER_Mouse0.49598505
108P53_21459846_ChIP-Seq_SAOS-2_Human0.45826265
109PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.45431757
110* CBP_21632823_ChIP-Seq_H3396_Human0.44358527
111ESR1_21235772_ChIP-Seq_MCF-7_Human0.44138043
112* STAT1_17558387_ChIP-Seq_HELA_Human0.44044476
113PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.43657627
114PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43538222
115CDX2_20551321_ChIP-Seq_CACO-2_Human0.42508190
116TAF2_19829295_ChIP-Seq_ESCs_Human0.42422383
117GATA1_19941827_ChIP-Seq_MEL_Mouse0.42313539
118SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42119934
119TAF15_26573619_Chip-Seq_HEK293_Human0.41972452
120FOXO3_23340844_ChIP-Seq_DLD1_Human0.41068009
121ERG_21242973_ChIP-ChIP_JURKAT_Human0.40392086
122CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.39847611
123FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.39676478
124GATA1_19941826_ChIP-Seq_K562_Human0.39258759
125MYC_27129775_Chip-Seq_CORNEA_Mouse0.38883483
126STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.38853446
127FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.38434168
128BCAT_22108803_ChIP-Seq_LS180_Human0.38121321
129GATA2_19941826_ChIP-Seq_K562_Human0.37453337
130GATA6_25053715_ChIP-Seq_YYC3_Human0.36973252
131PPAR_26484153_Chip-Seq_NCI-H1993_Human0.36842785
132GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.36772368
133SPI1_26923725_Chip-Seq_HPCs_Mouse0.36658864
134ESR1_20079471_ChIP-ChIP_T-47D_Human0.35880127
135SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.35361815
136CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.34554830
137NCOR_22424771_ChIP-Seq_293T_Human0.34246990
138* LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.33806013
139ERG_20517297_ChIP-Seq_VCAP_Human0.33357711
140FOXH1_21741376_ChIP-Seq_EPCs_Human0.33331409

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.40436062
2MP0005360_urolithiasis7.53415799
3MP0005085_abnormal_gallbladder_physiolo6.48942405
4MP0005365_abnormal_bile_salt6.19936891
5MP0008875_abnormal_xenobiotic_pharmacok5.05935089
6MP0003806_abnormal_nucleotide_metabolis4.26540240
7MP0003252_abnormal_bile_duct3.94102441
8MP0010329_abnormal_lipoprotein_level3.61423055
9MP0009840_abnormal_foam_cell3.33576916
10MP0005083_abnormal_biliary_tract3.06762191
11MP0003195_calcinosis2.80104392
12MP0005332_abnormal_amino_acid2.73448972
13MP0001666_abnormal_nutrient_absorption2.61255556
14MP0003191_abnormal_cellular_cholesterol2.37615535
15MP0000609_abnormal_liver_physiology2.16789395
16MP0002118_abnormal_lipid_homeostasis2.11127730
17MP0004019_abnormal_vitamin_homeostasis2.10362015
18MP0003868_abnormal_feces_composition1.95790569
19MP0002138_abnormal_hepatobiliary_system1.93456770
20MP0005319_abnormal_enzyme/_coenzyme1.83255090
21MP0001764_abnormal_homeostasis1.65383139
22MP0009697_abnormal_copulation1.59280577
23MP0005584_abnormal_enzyme/coenzyme_acti1.55893557
24MP0005451_abnormal_body_composition1.46010085
25MP0003011_delayed_dark_adaptation1.40632011
26MP0003656_abnormal_erythrocyte_physiolo1.27245435
27MP0003186_abnormal_redox_activity1.24364934
28MP0009643_abnormal_urine_homeostasis1.20545339
29MP0005647_abnormal_sex_gland1.19388680
30MP0000598_abnormal_liver_morphology1.17274199
31MP0003705_abnormal_hypodermis_morpholog1.17107469
32MP0000604_amyloidosis1.07950404
33MP0009764_decreased_sensitivity_to1.05123176
34MP0009763_increased_sensitivity_to1.01368707
35MP0001915_intracranial_hemorrhage1.00921591
36MP0002254_reproductive_system_inflammat1.00302142
37MP0010368_abnormal_lymphatic_system1.00181430
38MP0005636_abnormal_mineral_homeostasis0.91221745
39* MP0008469_abnormal_protein_level0.86254562
40* MP0009642_abnormal_blood_homeostasis0.85786057
41MP0005408_hypopigmentation0.83494126
42MP0006036_abnormal_mitochondrial_physio0.81239571
43MP0005376_homeostasis/metabolism_phenot0.79677111
44MP0005187_abnormal_penis_morphology0.78512933
45MP0002876_abnormal_thyroid_physiology0.78428759
46MP0005670_abnormal_white_adipose0.77787907
47MP0002078_abnormal_glucose_homeostasis0.77165311
48MP0009765_abnormal_xenobiotic_induced0.76754213
49MP0005084_abnormal_gallbladder_morpholo0.74318083
50MP0005220_abnormal_exocrine_pancreas0.72385748
51MP0002971_abnormal_brown_adipose0.70158313
52MP0004130_abnormal_muscle_cell0.68282459
53MP0005334_abnormal_fat_pad0.68180457
54MP0005535_abnormal_body_temperature0.67436857
55MP0003690_abnormal_glial_cell0.66830409
56MP0009053_abnormal_anal_canal0.65772596
57MP0001661_extended_life_span0.65390842
58MP0005266_abnormal_metabolism0.64725635
59MP0005058_abnormal_lysosome_morphology0.63258718
60MP0000639_abnormal_adrenal_gland0.61897359
61MP0003879_abnormal_hair_cell0.61655299
62MP0003329_amyloid_beta_deposits0.61437563
63MP0006035_abnormal_mitochondrial_morpho0.57274847
64MP0001756_abnormal_urination0.56873610
65MP0002282_abnormal_trachea_morphology0.56650525
66MP0005448_abnormal_energy_balance0.54581462
67MP0005464_abnormal_platelet_physiology0.51759632
68MP0000566_synostosis0.51546106
69MP0002822_catalepsy0.50899917
70MP0005395_other_phenotype0.48993260
71MP0004381_abnormal_hair_follicle0.48441554
72MP0003718_maternal_effect0.47585574
73MP0003638_abnormal_response/metabolism_0.45696933
74MP0008874_decreased_physiological_sensi0.44886446
75MP0002928_abnormal_bile_duct0.44779956
76MP0002249_abnormal_larynx_morphology0.43294195
77MP0008873_increased_physiological_sensi0.42845798
78MP0002136_abnormal_kidney_physiology0.42592739
79MP0003724_increased_susceptibility_to0.42072480
80MP0002837_dystrophic_cardiac_calcinosis0.41570933
81MP0003436_decreased_susceptibility_to0.41558805
82MP0004782_abnormal_surfactant_physiolog0.41158606
83MP0005023_abnormal_wound_healing0.40913061
84MP0003075_altered_response_to0.40563572
85MP0005166_decreased_susceptibility_to0.40169238
86MP0003953_abnormal_hormone_level0.40094398
87MP0005248_abnormal_Harderian_gland0.39637457
88MP0000579_abnormal_nail_morphology0.37900529
89MP0005666_abnormal_adipose_tissue0.36566081
90MP0009785_altered_susceptibility_to0.36311676
91MP0008872_abnormal_physiological_respon0.36077876
92MP0009672_abnormal_birth_weight0.35904073
93MP0002796_impaired_skin_barrier0.35257606
94MP0009384_cardiac_valve_regurgitation0.32982995
95MP0002089_abnormal_postnatal_growth/wei0.32653913
96MP0004883_abnormal_blood_vessel0.32640563
97MP0009115_abnormal_fat_cell0.32572259
98MP0000249_abnormal_blood_vessel0.31946171
99MP0006082_CNS_inflammation0.31707424
100MP0002970_abnormal_white_adipose0.30377392
101MP0000230_abnormal_systemic_arterial0.30297218
102MP0001243_abnormal_dermal_layer0.29677627
103MP0001853_heart_inflammation0.29452316
104MP0002168_other_aberrant_phenotype0.29324247
105MP0001881_abnormal_mammary_gland0.27042482
106MP0001845_abnormal_inflammatory_respons0.26996887
107MP0003959_abnormal_lean_body0.26849813
108MP0002132_abnormal_respiratory_system0.26024181
109MP0005164_abnormal_response_to0.25439303
110MP0004272_abnormal_basement_membrane0.25085964
111MP0005197_abnormal_uvea_morphology0.23231574
112MP0003122_maternal_imprinting0.23125960
113MP0002060_abnormal_skin_morphology0.23011290
114MP0000427_abnormal_hair_cycle0.22277312
115MP0003632_abnormal_nervous_system0.20963567
116MP0001986_abnormal_taste_sensitivity0.20890066
117MP0002090_abnormal_vision0.20362841
118MP0000920_abnormal_myelination0.19227393
119MP0001944_abnormal_pancreas_morphology0.18619410
120MP0002128_abnormal_blood_circulation0.17868441
121MP0003172_abnormal_lysosome_physiology0.17853231
122MP0001851_eye_inflammation0.16353754

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.49368637
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.41639840
3Intrahepatic cholestasis (HP:0001406)7.40057286
4Prolonged partial thromboplastin time (HP:0003645)6.67284706
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.65085343
6Hypobetalipoproteinemia (HP:0003563)6.39698503
7Xanthomatosis (HP:0000991)6.26779915
8Hyperlipoproteinemia (HP:0010980)5.64466917
9Complement deficiency (HP:0004431)5.62167191
10Joint hemorrhage (HP:0005261)4.85493778
11Hypolipoproteinemia (HP:0010981)4.82204326
12Hyperammonemia (HP:0001987)4.58784374
13Abnormality of the common coagulation pathway (HP:0010990)4.49151207
14Hyperglycinemia (HP:0002154)4.47611776
15Epidermoid cyst (HP:0200040)4.44741518
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.39210575
17Hypoalphalipoproteinemia (HP:0003233)4.26635509
18Ketosis (HP:0001946)4.26182999
19Abnormality of methionine metabolism (HP:0010901)4.24052912
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.21820471
21Fat malabsorption (HP:0002630)4.15954566
22Abnormality of complement system (HP:0005339)4.10584828
23Abnormality of aspartate family amino acid metabolism (HP:0010899)4.06841091
24Abnormality of glutamine family amino acid metabolism (HP:0010902)3.99938692
25Abnormality of glycine metabolism (HP:0010895)3.89425108
26Abnormality of serine family amino acid metabolism (HP:0010894)3.89425108
27Hyperglycinuria (HP:0003108)3.89252449
28Hypoglycemic coma (HP:0001325)3.88053915
29Abnormality of the intrinsic pathway (HP:0010989)3.84586317
30Abnormality of pyrimidine metabolism (HP:0004353)3.81313107
31Conjugated hyperbilirubinemia (HP:0002908)3.72275731
32Hypercholesterolemia (HP:0003124)3.55028683
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.38836854
34Abnormality of fatty-acid metabolism (HP:0004359)3.34984398
35Hyperbilirubinemia (HP:0002904)3.32007248
36Osteomalacia (HP:0002749)3.30192075
37Steatorrhea (HP:0002570)3.18130227
38Delayed CNS myelination (HP:0002188)3.10965458
39Hypochromic microcytic anemia (HP:0004840)3.08130467
40Spontaneous abortion (HP:0005268)3.07376448
41Abnormality of serum amino acid levels (HP:0003112)3.05835456
42Abnormality of nucleobase metabolism (HP:0010932)3.03687072
43Ketoacidosis (HP:0001993)2.99300832
44Hepatocellular carcinoma (HP:0001402)2.98373080
45Myocardial infarction (HP:0001658)2.96753401
46Systemic lupus erythematosus (HP:0002725)2.85132358
47Metabolic acidosis (HP:0001942)2.74632437
48Skin nodule (HP:0200036)2.73308100
49Reduced antithrombin III activity (HP:0001976)2.68598874
50Abnormality of purine metabolism (HP:0004352)2.64874055
51Purpura (HP:0000979)2.59767784
52Lethargy (HP:0001254)2.58744831
53Dicarboxylic aciduria (HP:0003215)2.57691479
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.57691479
55Vascular calcification (HP:0004934)2.54581238
56Recurrent gram-negative bacterial infections (HP:0005420)2.52343259
57Hypoglycemic seizures (HP:0002173)2.48969645
58Abnormal gallbladder morphology (HP:0012437)2.47469426
59Gout (HP:0001997)2.45954172
60Spastic diplegia (HP:0001264)2.45089140
61Acanthocytosis (HP:0001927)2.44209600
62Cholelithiasis (HP:0001081)2.42279115
63Mitral stenosis (HP:0001718)2.41816559
64Glomerulonephritis (HP:0000099)2.41312303
65Fair hair (HP:0002286)2.39716096
66Arthropathy (HP:0003040)2.38998968
67Cerebral edema (HP:0002181)2.38120276
68Abnormal gallbladder physiology (HP:0012438)2.37145214
69Cholecystitis (HP:0001082)2.37145214
70Neonatal onset (HP:0003623)2.37095394
71Irritability (HP:0000737)2.32931921
72Pulmonary embolism (HP:0002204)2.32664613
73Amyloidosis (HP:0011034)2.32055457
74Cardiovascular calcification (HP:0011915)2.25484382
75Malnutrition (HP:0004395)2.22569277
76Hyperphosphaturia (HP:0003109)2.22261212
77Gingival bleeding (HP:0000225)2.22139243
78Sensorimotor neuropathy (HP:0007141)2.19542673
79Esophageal varix (HP:0002040)2.17318606
80Menorrhagia (HP:0000132)2.15958059
81Pancreatitis (HP:0001733)2.15747152
82Late onset (HP:0003584)2.12976919
83Brushfield spots (HP:0001088)2.12846322
84Enlarged kidneys (HP:0000105)2.11504976
85Thrombophlebitis (HP:0004418)2.10244127
86Abnormality of the Achilles tendon (HP:0005109)2.09600650
87Vomiting (HP:0002013)2.05178981
88Opisthotonus (HP:0002179)2.04491931
89Neonatal hypoglycemia (HP:0001998)2.03521154
90Glycosuria (HP:0003076)2.03508953
91Abnormality of urine glucose concentration (HP:0011016)2.03508953
92Hyperinsulinemic hypoglycemia (HP:0000825)2.02403603
93Abnormality of the gallbladder (HP:0005264)2.02180174
94Hemorrhage of the eye (HP:0011885)2.01806285
95Generalized aminoaciduria (HP:0002909)2.00280646
96Elevated alkaline phosphatase (HP:0003155)1.99707225
97Poikilocytosis (HP:0004447)1.96659311
98Rickets (HP:0002748)1.93705821
99Bifid scrotum (HP:0000048)1.92393056
100Abnormality of iron homeostasis (HP:0011031)1.90257526
101Abnormal biliary tract physiology (HP:0012439)1.88969010
102Bile duct proliferation (HP:0001408)1.88969010
103Hypophosphatemic rickets (HP:0004912)1.86871098
104Abnormality of transition element cation homeostasis (HP:0011030)1.86527975
105Abnormal cartilage morphology (HP:0002763)1.86444332
106Renal cortical cysts (HP:0000803)1.84352410
107Elevated hepatic transaminases (HP:0002910)1.82558855
108Abnormality of alkaline phosphatase activity (HP:0004379)1.82146621
109Abnormal enzyme/coenzyme activity (HP:0012379)1.81426274
110Increased serum ferritin (HP:0003281)1.80878624
111Status epilepticus (HP:0002133)1.80760302
112Abnormal urine phosphate concentration (HP:0012599)1.79728536
113Hydroxyprolinuria (HP:0003080)1.76555349
114Abnormality of proline metabolism (HP:0010907)1.76555349
115Hyperglycemia (HP:0003074)1.75462380
116Gangrene (HP:0100758)1.73038729
117Increased mean platelet volume (HP:0011877)1.71653765
118Abnormality of vitamin metabolism (HP:0100508)1.71334481
119Nephritis (HP:0000123)1.71317226
120Alkalosis (HP:0001948)1.71033293
121Epistaxis (HP:0000421)1.70778941
122Joint swelling (HP:0001386)1.62039537
123Generalized hypopigmentation of hair (HP:0011358)1.59635666
124Hypophosphatemia (HP:0002148)1.56172822
125Reticulocytosis (HP:0001923)1.55475320
126Abnormal platelet volume (HP:0011876)1.53800387
127Abnormal platelet function (HP:0011869)1.53353827
128Impaired platelet aggregation (HP:0003540)1.53353827

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.25364179
2FGFR44.74245476
3ERN14.72301197
4SIK14.53888528
5TAOK33.15031207
6ERBB43.06666624
7PIK3CA2.90062938
8INSRR2.86064734
9MAP2K42.38085231
10PKN22.07683833
11MST1R2.03556781
12MAPK111.94295314
13FLT31.81544097
14TRIB31.79651316
15PIK3CG1.74987436
16TYK21.68831680
17BLK1.66968142
18LATS11.65076387
19PRPF4B1.59207880
20CDK121.52513881
21DAPK21.50424664
22ABL21.49441770
23PTK61.44680345
24NEK91.38673948
25MAP3K21.34945485
26FGFR21.33181297
27KDR1.30422704
28EIF2AK11.30284344
29FRK1.23397499
30JAK21.22880992
31NTRK31.22209016
32MAP3K71.18373925
33PINK11.12272459
34GRK61.09522127
35PRKAA21.09344098
36MAP2K31.06745558
37ERBB21.04695747
38SCYL21.04528897
39TBK11.03983970
40JAK11.00434826
41MAPK40.98767002
42MAP3K100.96245194
43NLK0.95991187
44PRKG10.94484974
45PRKCZ0.92844634
46MAP3K140.91240495
47STK38L0.89907944
48CSNK1D0.88880727
49MAPK150.88434749
50EPHB10.86217787
51MAPK120.82626863
52MET0.82138124
53CDK60.81489547
54MAP3K30.81169327
55MAP3K110.80028706
56TIE10.79733477
57SGK10.78771532
58EPHA30.78641169
59PDK20.77452237
60PRKACG0.75507347
61CAMK2G0.73940118
62PRKACA0.71587960
63TNK20.71163865
64DYRK1B0.69896304
65GSK3A0.66998734
66MAP2K60.66946026
67CSK0.66043002
68PRKCB0.65494889
69PRKAA10.65378719
70IRAK30.65318300
71RPS6KA30.63862152
72CAMK1D0.63810805
73FGFR10.63184022
74CSNK1E0.60908951
75SGK30.60727869
76MAPK70.59776430
77WNK30.58260572
78PDGFRA0.57676522
79PTK20.56251858
80RIPK10.56183587
81MUSK0.55264315
82CSF1R0.54464519
83FGFR30.54006614
84TGFBR20.53527675
85RPS6KB10.53502384
86IKBKE0.52473448
87CSNK2A20.52429101
88CSNK2A10.51218876
89PDPK10.50588495
90TAOK20.50022776
91WNK40.49916545
92PRKCQ0.49551187
93CSNK1G10.49124926
94FER0.48717120
95PRKACB0.48567784
96MAP3K120.47988681
97PKN10.46785236
98GRK10.46283983
99EPHA40.45998130
100SRC0.45771026
101MAP3K50.44076311
102SGK20.43949957
103PRKCG0.43410870
104CDK40.43404179
105KSR20.43198472
106ZAP700.42682234
107ICK0.42330696
108IGF1R0.41881235
109STK380.39892915
110MAP2K10.39433111
111CAMKK20.39413286
112RET0.39257386
113MAP3K130.38633616
114MAP3K60.37906821
115CDK70.37698342
116MYLK0.37635024
117MTOR0.35668459
118LATS20.35531945
119CAMKK10.35073171
120MAPK30.34915962
121CSNK1A10.34797640
122EGFR0.34343262
123CAMK40.33969989
124NEK10.32252023
125MAP3K10.32088246
126PBK0.29493713
127PDK10.29300808
128SGK4940.28803451
129SGK2230.28803451
130CSNK1G20.28192018
131CSNK1G30.27022890
132IRAK10.25399170
133PRKCA0.25261649
134IRAK20.24044565
135CAMK1G0.21143831
136MAP2K20.20807210
137ABL10.20803785
138PAK30.20028746
139BMX0.19301479
140AKT30.19130960

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.63560458
2Nitrogen metabolism_Homo sapiens_hsa009103.50961470
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.39597781
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.30363642
5Arginine biosynthesis_Homo sapiens_hsa002203.03807121
6Complement and coagulation cascades_Homo sapiens_hsa046102.83313490
7Tryptophan metabolism_Homo sapiens_hsa003802.70468203
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.70393408
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.67081831
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.54940296
11Fatty acid degradation_Homo sapiens_hsa000712.50010195
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.39443413
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.21019603
14Butanoate metabolism_Homo sapiens_hsa006502.17165908
15Peroxisome_Homo sapiens_hsa041462.10340302
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.09774429
17Steroid hormone biosynthesis_Homo sapiens_hsa001401.92497292
18Chemical carcinogenesis_Homo sapiens_hsa052041.91746838
19Propanoate metabolism_Homo sapiens_hsa006401.90575750
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.89094653
21Histidine metabolism_Homo sapiens_hsa003401.89005428
22PPAR signaling pathway_Homo sapiens_hsa033201.88400121
23Fatty acid metabolism_Homo sapiens_hsa012121.82306535
24Staphylococcus aureus infection_Homo sapiens_hsa051501.77820971
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.75280094
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.72446570
27beta-Alanine metabolism_Homo sapiens_hsa004101.70834553
28Retinol metabolism_Homo sapiens_hsa008301.69759207
29Caffeine metabolism_Homo sapiens_hsa002321.68393035
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.66823087
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.64906510
32Selenocompound metabolism_Homo sapiens_hsa004501.57020060
33Phenylalanine metabolism_Homo sapiens_hsa003601.56867219
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51959533
35Bile secretion_Homo sapiens_hsa049761.50179309
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49836274
37Tyrosine metabolism_Homo sapiens_hsa003501.46697657
38Fatty acid elongation_Homo sapiens_hsa000621.37135085
39Pyruvate metabolism_Homo sapiens_hsa006201.36287902
40Sulfur metabolism_Homo sapiens_hsa009201.34022374
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.31203018
42Starch and sucrose metabolism_Homo sapiens_hsa005001.25851144
43Folate biosynthesis_Homo sapiens_hsa007901.23359560
44ABC transporters_Homo sapiens_hsa020101.18783992
45Biosynthesis of amino acids_Homo sapiens_hsa012301.17998446
46Steroid biosynthesis_Homo sapiens_hsa001001.17369323
47Fat digestion and absorption_Homo sapiens_hsa049751.17356706
48Carbon metabolism_Homo sapiens_hsa012001.11471774
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05596429
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.03625358
51Vitamin B6 metabolism_Homo sapiens_hsa007501.01685904
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.98598910
53Sulfur relay system_Homo sapiens_hsa041220.98245787
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96279567
55Arginine and proline metabolism_Homo sapiens_hsa003300.95498332
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87569867
57Vitamin digestion and absorption_Homo sapiens_hsa049770.84793093
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81999625
59Lysine degradation_Homo sapiens_hsa003100.80659834
60One carbon pool by folate_Homo sapiens_hsa006700.76683058
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69276503
62Glycerolipid metabolism_Homo sapiens_hsa005610.66430550
63Glutathione metabolism_Homo sapiens_hsa004800.63094559
64Pentose phosphate pathway_Homo sapiens_hsa000300.56437674
65Fatty acid biosynthesis_Homo sapiens_hsa000610.52394653
66Metabolic pathways_Homo sapiens_hsa011000.45987896
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44854939
68Prion diseases_Homo sapiens_hsa050200.44283893
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43480235
70Pertussis_Homo sapiens_hsa051330.32923804
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26573344
72Galactose metabolism_Homo sapiens_hsa000520.25768864
73Insulin resistance_Homo sapiens_hsa049310.23208264
74Linoleic acid metabolism_Homo sapiens_hsa005910.22975202
75Fructose and mannose metabolism_Homo sapiens_hsa000510.22844546
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.21808367
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19145300
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.16550826
79Glucagon signaling pathway_Homo sapiens_hsa049220.10517589
80Other glycan degradation_Homo sapiens_hsa005110.09974817
81AMPK signaling pathway_Homo sapiens_hsa041520.01936046
82Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2373835
83Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2358379
84Ether lipid metabolism_Homo sapiens_hsa00565-0.2338052
85Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2259515
86Amoebiasis_Homo sapiens_hsa05146-0.2225223
87Renin-angiotensin system_Homo sapiens_hsa04614-0.1966862
88Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1914867
89Circadian rhythm_Homo sapiens_hsa04710-0.1914733
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1810910
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1796369
92Hepatitis C_Homo sapiens_hsa05160-0.1761481
93Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1602380
94Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1526981
95Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1516347
96Type II diabetes mellitus_Homo sapiens_hsa04930-0.1479024
97Mineral absorption_Homo sapiens_hsa04978-0.1427905
98N-Glycan biosynthesis_Homo sapiens_hsa00510-0.1393069
99Sphingolipid metabolism_Homo sapiens_hsa00600-0.1365693
100Regulation of autophagy_Homo sapiens_hsa04140-0.1286060
101African trypanosomiasis_Homo sapiens_hsa05143-0.1272093
102Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1214887
103Insulin signaling pathway_Homo sapiens_hsa04910-0.1009506
104Serotonergic synapse_Homo sapiens_hsa04726-0.0868408
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0730698
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0713669
107Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0706019
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0385835

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