ING1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)5.77072001
2viral transcription (GO:0019083)5.58353927
3translational termination (GO:0006415)5.40772476
4maturation of SSU-rRNA (GO:0030490)4.57665839
5cotranslational protein targeting to membrane (GO:0006613)4.55207582
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.46370831
7protein targeting to ER (GO:0045047)4.45155895
8nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.34911677
9cellular protein complex disassembly (GO:0043624)4.33907952
10ribosomal small subunit assembly (GO:0000028)4.28393215
11establishment of protein localization to endoplasmic reticulum (GO:0072599)4.28030520
12translational elongation (GO:0006414)4.27028182
13viral life cycle (GO:0019058)4.21238792
14protein complex biogenesis (GO:0070271)4.15614418
15protein localization to endoplasmic reticulum (GO:0070972)4.14993777
16translational initiation (GO:0006413)4.09589592
17mitochondrial respiratory chain complex assembly (GO:0033108)4.06793524
18behavioral response to nicotine (GO:0035095)3.93902991
19sulfation (GO:0051923)3.89321159
20protein complex disassembly (GO:0043241)3.81148218
21ribosomal large subunit biogenesis (GO:0042273)3.79490671
22negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.73865828
23negative regulation of translation, ncRNA-mediated (GO:0040033)3.73865828
24regulation of translation, ncRNA-mediated (GO:0045974)3.73865828
25cell proliferation in forebrain (GO:0021846)3.59639795
26axon ensheathment in central nervous system (GO:0032291)3.57363494
27central nervous system myelination (GO:0022010)3.57363494
28regulation of DNA endoreduplication (GO:0032875)3.55127052
29somite development (GO:0061053)3.51609079
30macromolecular complex disassembly (GO:0032984)3.50926607
31histone H2B ubiquitination (GO:0033523)3.48441145
32establishment of integrated proviral latency (GO:0075713)3.43400826
33mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.40772527
34regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.31523276
35epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.30048544
36DNA deamination (GO:0045006)3.29172997
37nuclear-transcribed mRNA catabolic process (GO:0000956)3.29093877
38kinetochore assembly (GO:0051382)3.24267632
39regulation of nuclear cell cycle DNA replication (GO:0033262)3.24115874
40water-soluble vitamin biosynthetic process (GO:0042364)3.20776950
41ATP synthesis coupled proton transport (GO:0015986)3.19499910
42energy coupled proton transport, down electrochemical gradient (GO:0015985)3.19499910
43mitotic metaphase plate congression (GO:0007080)3.19465111
44termination of RNA polymerase III transcription (GO:0006386)3.19368833
45transcription elongation from RNA polymerase III promoter (GO:0006385)3.19368833
46limb bud formation (GO:0060174)3.19076280
47kinetochore organization (GO:0051383)3.18014328
48protein polyglutamylation (GO:0018095)3.17456331
49microtubule depolymerization (GO:0007019)3.16387418
50negative regulation of DNA-dependent DNA replication (GO:2000104)3.14179343
51mRNA catabolic process (GO:0006402)3.13893803
52protein neddylation (GO:0045116)3.13786248
53negative regulation of mast cell activation (GO:0033004)3.12695158
54negative regulation of transcription regulatory region DNA binding (GO:2000678)3.10869682
55protein-cofactor linkage (GO:0018065)3.09093372
56regulation of cilium movement (GO:0003352)3.04991646
57single strand break repair (GO:0000012)3.03498059
58response to pheromone (GO:0019236)3.03422414
59DNA damage response, detection of DNA damage (GO:0042769)3.02794815
60rRNA processing (GO:0006364)3.02664932
61ribonucleoprotein complex biogenesis (GO:0022613)3.00769730
62protein targeting to membrane (GO:0006612)2.99628153
63neural tube formation (GO:0001841)2.99186530
64CENP-A containing nucleosome assembly (GO:0034080)2.95950493
65establishment of protein localization to mitochondrial membrane (GO:0090151)2.95640090
66pyrimidine nucleobase catabolic process (GO:0006208)2.94495741
67replication fork processing (GO:0031297)2.93092679
68regulation of mesoderm development (GO:2000380)2.92145583
69cornea development in camera-type eye (GO:0061303)2.91940722
70protein K6-linked ubiquitination (GO:0085020)2.91839028
71RNA catabolic process (GO:0006401)2.91694976
72rRNA metabolic process (GO:0016072)2.91432480
73transcription elongation from RNA polymerase I promoter (GO:0006362)2.90547125
74long-chain fatty acid biosynthetic process (GO:0042759)2.90369018
75translation (GO:0006412)2.89792676
767-methylguanosine mRNA capping (GO:0006370)2.89773610
77microtubule polymerization or depolymerization (GO:0031109)2.89519745
78negative regulation of telomere maintenance (GO:0032205)2.89258116
79detection of light stimulus involved in sensory perception (GO:0050962)2.88560245
80detection of light stimulus involved in visual perception (GO:0050908)2.88560245
817-methylguanosine RNA capping (GO:0009452)2.85537388
82RNA capping (GO:0036260)2.85537388
83attachment of spindle microtubules to kinetochore (GO:0008608)2.84851317
84establishment of viral latency (GO:0019043)2.82840781
85metaphase plate congression (GO:0051310)2.80653506
86regulation of collateral sprouting (GO:0048670)2.80447218
87spinal cord development (GO:0021510)2.79085609
88dentate gyrus development (GO:0021542)2.78983523
89regulation of telomere maintenance (GO:0032204)2.78431478
90chromatin remodeling at centromere (GO:0031055)2.78060141
91hindbrain development (GO:0030902)2.77287918
92exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.73984388
93termination of RNA polymerase I transcription (GO:0006363)2.73810248
94nephron epithelium morphogenesis (GO:0072088)2.73346088
95nephron tubule morphogenesis (GO:0072078)2.73346088
96nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.72079449
97L-fucose catabolic process (GO:0042355)2.71061845
98fucose catabolic process (GO:0019317)2.71061845
99L-fucose metabolic process (GO:0042354)2.71061845
100DNA ligation (GO:0006266)2.69733500
101pseudouridine synthesis (GO:0001522)2.68441322
102cardiovascular system development (GO:0072358)2.68335121
103mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.65847678
104positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.65847678
105protein localization to kinetochore (GO:0034501)2.65230174
106detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.64674830
107kidney morphogenesis (GO:0060993)2.63059782
108intracellular protein transmembrane import (GO:0044743)2.61766748
109positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.61566072
110transmission of nerve impulse (GO:0019226)2.61079880
111epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.60960331
112proteasome assembly (GO:0043248)2.60078972
113presynaptic membrane assembly (GO:0097105)2.58643305
114protein localization to chromosome, centromeric region (GO:0071459)2.58568706
115epithelial cilium movement (GO:0003351)2.56946049
116histone exchange (GO:0043486)2.54473491
117transcription elongation from RNA polymerase II promoter (GO:0006368)2.52645579
118DNA-templated transcription, elongation (GO:0006354)2.51111204
119respiratory chain complex IV assembly (GO:0008535)2.50275148
120lymphoid progenitor cell differentiation (GO:0002320)2.49481664
121artery development (GO:0060840)2.49471174
122transcription-coupled nucleotide-excision repair (GO:0006283)2.48789125
123nucleotide-excision repair, DNA gap filling (GO:0006297)2.48445286
124regulation of posttranscriptional gene silencing (GO:0060147)2.48385443
125regulation of gene silencing by miRNA (GO:0060964)2.48385443
126regulation of gene silencing by RNA (GO:0060966)2.48385443
127isoprenoid biosynthetic process (GO:0008299)2.47537092
128DNA replication-independent nucleosome assembly (GO:0006336)2.47212744
129DNA replication-independent nucleosome organization (GO:0034724)2.47212744
130mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.46953837
131mitochondrial respiratory chain complex I assembly (GO:0032981)2.46953837
132NADH dehydrogenase complex assembly (GO:0010257)2.46953837
133indolalkylamine metabolic process (GO:0006586)2.45406503
134spliceosomal complex assembly (GO:0000245)2.45160006
135DNA replication checkpoint (GO:0000076)2.44491398
136cellular component biogenesis (GO:0044085)2.43348907
137centriole replication (GO:0007099)2.43009065
138spermatid nucleus differentiation (GO:0007289)2.42929687
139neuron fate determination (GO:0048664)2.42727203
140spliceosomal snRNP assembly (GO:0000387)2.42489403
141histone mRNA metabolic process (GO:0008334)2.42089502
142regulation of exit from mitosis (GO:0007096)2.41065083
143indole-containing compound catabolic process (GO:0042436)2.39837596
144indolalkylamine catabolic process (GO:0046218)2.39837596
145tryptophan catabolic process (GO:0006569)2.39837596
146alternative mRNA splicing, via spliceosome (GO:0000380)2.38673800
147positive regulation of viral transcription (GO:0050434)2.37118905
148head development (GO:0060322)2.37040729
149piRNA metabolic process (GO:0034587)2.36554853
150outer ear morphogenesis (GO:0042473)2.36408742
151presynaptic membrane organization (GO:0097090)2.36356225
152positive regulation of protein homodimerization activity (GO:0090073)2.35353870
153endoderm formation (GO:0001706)2.34731086
154forebrain neuron differentiation (GO:0021879)2.34614940
155positive regulation of chromosome segregation (GO:0051984)2.34314503
156negative regulation of DNA-templated transcription, elongation (GO:0032785)2.34218727
157negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.34218727
158cell fate commitment involved in formation of primary germ layer (GO:0060795)2.33748331
159negative regulation of synaptic transmission, GABAergic (GO:0032229)2.33014941
160cilium morphogenesis (GO:0060271)2.32788631
161resolution of meiotic recombination intermediates (GO:0000712)2.32641274
162transcription from RNA polymerase I promoter (GO:0006360)2.32388627
163myelination (GO:0042552)2.31801513
164axonemal dynein complex assembly (GO:0070286)2.31086032
165positive regulation of gastrulation (GO:2000543)2.31035355
166ensheathment of neurons (GO:0007272)2.30671296
167axon ensheathment (GO:0008366)2.30671296
168meiotic chromosome segregation (GO:0045132)2.30611890
169regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.29587480
170electron transport chain (GO:0022900)2.28760759
171establishment of chromosome localization (GO:0051303)2.28143539
172regulation of transcription elongation from RNA polymerase II promoter (GO:0034243)2.27920390
173chaperone-mediated protein transport (GO:0072321)2.27761256
174L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.27341186
175somatic diversification of immune receptors via somatic mutation (GO:0002566)2.27255413
176somatic hypermutation of immunoglobulin genes (GO:0016446)2.27255413
177anterograde axon cargo transport (GO:0008089)2.27069473
178gamma-aminobutyric acid transport (GO:0015812)2.26821144
179tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.26381015
180RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.26381015
181formation of translation preinitiation complex (GO:0001731)2.26180311
182mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.26053077

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.89530861
2E2F7_22180533_ChIP-Seq_HELA_Human4.71498626
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.55579933
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.75506643
5ZNF274_21170338_ChIP-Seq_K562_Hela3.69375202
6EZH2_22144423_ChIP-Seq_EOC_Human3.63112820
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.47502743
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.43222038
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.38058827
10GABP_17652178_ChIP-ChIP_JURKAT_Human3.34910095
11* CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.12070583
12EST1_17652178_ChIP-ChIP_JURKAT_Human3.11173333
13E2F4_17652178_ChIP-ChIP_JURKAT_Human3.04342532
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.99740060
15* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.83622829
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.77454696
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.68687496
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.56685744
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.40305280
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.28193761
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.27663852
22XRN2_22483619_ChIP-Seq_HELA_Human2.27024052
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.22527974
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.17650534
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.15078146
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14653094
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.14016398
28TTF2_22483619_ChIP-Seq_HELA_Human2.04493887
29CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02627788
30MYC_18358816_ChIP-ChIP_MESCs_Mouse1.98345567
31* VDR_23849224_ChIP-Seq_CD4+_Human1.97626557
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.93470601
33IGF1R_20145208_ChIP-Seq_DFB_Human1.87745675
34P300_19829295_ChIP-Seq_ESCs_Human1.86076813
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.84546526
36DCP1A_22483619_ChIP-Seq_HELA_Human1.83151436
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79186246
38FUS_26573619_Chip-Seq_HEK293_Human1.78204551
39GBX2_23144817_ChIP-Seq_PC3_Human1.77464171
40MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.73496611
41* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72651676
42ELK1_19687146_ChIP-ChIP_HELA_Human1.71513910
43* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.70885510
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.70714154
45MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.68080538
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67909390
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.65786253
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62680863
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.58624916
50KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.58462574
51KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.58462574
52KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.58462574
53SALL1_21062744_ChIP-ChIP_HESCs_Human1.57710294
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.55656133
55ER_23166858_ChIP-Seq_MCF-7_Human1.51427126
56FOXP3_21729870_ChIP-Seq_TREG_Human1.50191117
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.49826772
58KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.49155026
59MYC_18940864_ChIP-ChIP_HL60_Human1.46287321
60* PIAS1_25552417_ChIP-Seq_VCAP_Human1.44820284
61VDR_22108803_ChIP-Seq_LS180_Human1.42779178
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42275762
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42275762
64AR_21909140_ChIP-Seq_LNCAP_Human1.41060158
65* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.38696653
66ELK1_22589737_ChIP-Seq_MCF10A_Human1.37663793
67BCAT_22108803_ChIP-Seq_LS180_Human1.35879215
68EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.35185462
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.35000808
70EED_16625203_ChIP-ChIP_MESCs_Mouse1.33968788
71EZH2_27304074_Chip-Seq_ESCs_Mouse1.33521916
72RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33056889
73REST_21632747_ChIP-Seq_MESCs_Mouse1.31489730
74NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.29368092
75MYCN_18555785_ChIP-Seq_MESCs_Mouse1.29012798
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28181603
77SOX2_18555785_ChIP-Seq_MESCs_Mouse1.28151955
78* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28015728
79AR_25329375_ChIP-Seq_VCAP_Human1.26538124
80FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.25922396
81EWS_26573619_Chip-Seq_HEK293_Human1.25197823
82TP53_22573176_ChIP-Seq_HFKS_Human1.24845055
83IRF1_19129219_ChIP-ChIP_H3396_Human1.24727649
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24480183
85NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24375699
86ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.24213324
87AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21292904
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21115557
89YY1_21170310_ChIP-Seq_MESCs_Mouse1.20925543
90* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19306117
91* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.17546610
92ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17404895
93SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16784345
94BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14893829
95SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.14273621
96SOX2_16153702_ChIP-ChIP_HESCs_Human1.14068821
97TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13857680
98TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12903280
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12106333
100NOTCH1_21737748_ChIP-Seq_TLL_Human1.11813044
101RNF2_27304074_Chip-Seq_NSC_Mouse1.11398251
102* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11298156
103GATA3_21878914_ChIP-Seq_MCF-7_Human1.10704124
104GABP_19822575_ChIP-Seq_HepG2_Human1.10038073
105CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09773585
106CBX2_27304074_Chip-Seq_ESCs_Mouse1.08702892
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08570747
108RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04272160
109PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.03940970
110NANOG_19829295_ChIP-Seq_ESCs_Human1.03742692
111SOX2_19829295_ChIP-Seq_ESCs_Human1.03742692
112* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02634691
113NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02554487
114CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02516367
115TAF15_26573619_Chip-Seq_HEK293_Human1.01986314
116ELF1_17652178_ChIP-ChIP_JURKAT_Human1.00572281
117FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98970034
118FOXA1_25329375_ChIP-Seq_VCAP_Human0.98970034
119SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.98956403
120JARID2_20064375_ChIP-Seq_MESCs_Mouse0.98768112
121STAT3_23295773_ChIP-Seq_U87_Human0.98320895
122KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97960405
123TCF4_22108803_ChIP-Seq_LS180_Human0.97796503
124IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97745637
125CBP_20019798_ChIP-Seq_JUKART_Human0.97745637
126TCF4_23295773_ChIP-Seq_U87_Human0.97090858
127SMAD3_21741376_ChIP-Seq_EPCs_Human0.96688826
128CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96644100
129FLI1_21867929_ChIP-Seq_TH2_Mouse0.96591271
130YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96030829
131NCOR_22424771_ChIP-Seq_293T_Human0.95768102
132KDM5A_27292631_Chip-Seq_BREAST_Human0.94439527
133SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93568190
134TCF3_18692474_ChIP-Seq_MEFs_Mouse0.93514243
135SMAD4_21799915_ChIP-Seq_A2780_Human0.93187071
136PRDM14_20953172_ChIP-Seq_ESCs_Human0.92775942
137RUNX2_22187159_ChIP-Seq_PCA_Human0.92752267
138SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.92604237
139FLI1_27457419_Chip-Seq_LIVER_Mouse0.89667105
140PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.88695097
141HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.88465013
142* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.83847815
143PADI4_21655091_ChIP-ChIP_MCF-7_Human0.83614101
144* SOX17_20123909_ChIP-Seq_XEN_Mouse0.83588519
145NANOG_18692474_ChIP-Seq_MEFs_Mouse0.83380284
146NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.82406647
147TCF3_18692474_ChIP-Seq_MESCs_Mouse0.82239388
148E2F1_21310950_ChIP-Seq_MCF-7_Human0.82066507
149GATA1_26923725_Chip-Seq_HPCs_Mouse0.78512703
150* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.78006843
151ERG_20887958_ChIP-Seq_HPC-7_Mouse0.77336726
152KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.76822480
153STAT1_20625510_ChIP-Seq_HELA_Human0.75571813
154* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.75549459
155CIITA_25753668_ChIP-Seq_RAJI_Human0.73859429
156* SRF_21415370_ChIP-Seq_HL-1_Mouse0.71367084
157RBPJ_22232070_ChIP-Seq_NCS_Mouse0.70337405
158PCGF2_27294783_Chip-Seq_ESCs_Mouse0.70032672
159TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.69312963
160BP1_19119308_ChIP-ChIP_Hs578T_Human0.68397930
161* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.66457245

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.59498782
2MP0008057_abnormal_DNA_replication3.12323809
3MP0001346_abnormal_lacrimal_gland2.91029068
4MP0003693_abnormal_embryo_hatching2.67517791
5MP0004957_abnormal_blastocyst_morpholog2.45708575
6MP0010094_abnormal_chromosome_stability2.31059011
7MP0001968_abnormal_touch/_nociception2.22794661
8MP0003787_abnormal_imprinting2.19771008
9MP0001348_abnormal_lacrimal_gland2.18715730
10* MP0003077_abnormal_cell_cycle2.17542654
11MP0003941_abnormal_skin_development2.15684679
12MP0001529_abnormal_vocalization2.07795186
13MP0002735_abnormal_chemical_nociception2.07213963
14MP0002928_abnormal_bile_duct2.05079247
15MP0003111_abnormal_nucleus_morphology2.04268116
16MP0003880_abnormal_central_pattern2.02851482
17MP0003136_yellow_coat_color2.02169233
18MP0000566_synostosis2.01608647
19MP0005084_abnormal_gallbladder_morpholo1.92863368
20MP0004885_abnormal_endolymph1.91296356
21MP0002653_abnormal_ependyma_morphology1.87864960
22MP0006292_abnormal_olfactory_placode1.86969793
23MP0003011_delayed_dark_adaptation1.84490853
24MP0002254_reproductive_system_inflammat1.84122934
25MP0005551_abnormal_eye_electrophysiolog1.83167004
26MP0000685_abnormal_immune_system1.81152115
27MP0008932_abnormal_embryonic_tissue1.79003049
28MP0001905_abnormal_dopamine_level1.76506080
29MP0003938_abnormal_ear_development1.74336398
30MP0005253_abnormal_eye_physiology1.72761132
31MP0008877_abnormal_DNA_methylation1.70720298
32MP0004133_heterotaxia1.69783012
33MP0000383_abnormal_hair_follicle1.66123130
34MP0008058_abnormal_DNA_repair1.63712424
35MP0008872_abnormal_physiological_respon1.62687961
36MP0000569_abnormal_digit_pigmentation1.61311988
37MP0003119_abnormal_digestive_system1.60504135
38MP0003718_maternal_effect1.57099376
39MP0005423_abnormal_somatic_nervous1.56530945
40MP0001485_abnormal_pinna_reflex1.54282301
41MP0002160_abnormal_reproductive_system1.54129544
42MP0003937_abnormal_limbs/digits/tail_de1.50637625
43MP0005367_renal/urinary_system_phenotyp1.47597906
44MP0000516_abnormal_urinary_system1.47597906
45MP0009333_abnormal_splenocyte_physiolog1.45762314
46MP0009745_abnormal_behavioral_response1.45452808
47MP0009046_muscle_twitch1.44244495
48MP0008789_abnormal_olfactory_epithelium1.42439718
49MP0002272_abnormal_nervous_system1.41157691
50MP0001486_abnormal_startle_reflex1.40111179
51MP0003763_abnormal_thymus_physiology1.39409246
52MP0002102_abnormal_ear_morphology1.36951056
53MP0002938_white_spotting1.36865795
54MP0002163_abnormal_gland_morphology1.34636141
55MP0000372_irregular_coat_pigmentation1.33122146
56MP0001851_eye_inflammation1.29494604
57MP0001293_anophthalmia1.26682647
58MP0003567_abnormal_fetal_cardiomyocyte1.24649256
59MP0000920_abnormal_myelination1.24570372
60MP0005389_reproductive_system_phenotype1.23802882
61MP0005187_abnormal_penis_morphology1.23425628
62MP0005195_abnormal_posterior_eye1.22534242
63MP0000778_abnormal_nervous_system1.22437810
64MP0003315_abnormal_perineum_morphology1.21900452
65MP0000049_abnormal_middle_ear1.19513676
66MP0005451_abnormal_body_composition1.19387273
67MP0010678_abnormal_skin_adnexa1.18925478
68MP0009250_abnormal_appendicular_skeleto1.15347607
69* MP0000350_abnormal_cell_proliferation1.14655409
70MP0000462_abnormal_digestive_system1.12405831
71MP0005645_abnormal_hypothalamus_physiol1.12176938
72MP0006072_abnormal_retinal_apoptosis1.11925309
73MP0002638_abnormal_pupillary_reflex1.11689032
74MP0002210_abnormal_sex_determination1.11064071
75MP0001730_embryonic_growth_arrest1.09877367
76MP0002396_abnormal_hematopoietic_system1.09302646
77MP0003890_abnormal_embryonic-extraembry1.09173093
78MP0004381_abnormal_hair_follicle1.08676740
79MP0001502_abnormal_circadian_rhythm1.06910785
80MP0006082_CNS_inflammation1.06768510
81MP0002752_abnormal_somatic_nervous1.06271894
82MP0002067_abnormal_sensory_capabilities1.05912452
83MP0004134_abnormal_chest_morphology1.05161470
84MP0005377_hearing/vestibular/ear_phenot1.04823850
85MP0003878_abnormal_ear_physiology1.04823850
86MP0001929_abnormal_gametogenesis1.04629266
87* MP0002557_abnormal_social/conspecific_i1.04370053
88MP0002733_abnormal_thermal_nociception1.02783215
89MP0003385_abnormal_body_wall1.02281661
90MP0005671_abnormal_response_to1.00449451
91MP0002572_abnormal_emotion/affect_behav1.00027712
92MP0001970_abnormal_pain_threshold0.99264817
93MP0004742_abnormal_vestibular_system0.99253227
94MP0005391_vision/eye_phenotype0.99095365
95MP0001324_abnormal_eye_pigmentation0.98647157
96MP0002085_abnormal_embryonic_tissue0.98333308
97MP0010030_abnormal_orbit_morphology0.97653910
98MP0005646_abnormal_pituitary_gland0.97615197
99MP0003195_calcinosis0.97612087
100MP0005310_abnormal_salivary_gland0.97405213
101MP0005174_abnormal_tail_pigmentation0.96842001
102MP0001440_abnormal_grooming_behavior0.96778944
103MP0002138_abnormal_hepatobiliary_system0.95673837
104MP0001919_abnormal_reproductive_system0.93257955
105MP0008995_early_reproductive_senescence0.92770514
106MP0002751_abnormal_autonomic_nervous0.91454959
107MP0002233_abnormal_nose_morphology0.91360028
108* MP0008007_abnormal_cellular_replicative0.91118149
109MP0000613_abnormal_salivary_gland0.90786130
110MP0003755_abnormal_palate_morphology0.90514231
111MP0000631_abnormal_neuroendocrine_gland0.89803112
112MP0002009_preneoplasia0.88910971
113MP0006276_abnormal_autonomic_nervous0.88903599
114MP0003861_abnormal_nervous_system0.87738260
115MP0002277_abnormal_respiratory_mucosa0.87234566
116MP0001697_abnormal_embryo_size0.87149490
117* MP0000703_abnormal_thymus_morphology0.86599144
118MP0002063_abnormal_learning/memory/cond0.86314390
119MP0002064_seizures0.86064465
120MP0004145_abnormal_muscle_electrophysio0.85292990
121MP0001145_abnormal_male_reproductive0.84663517
122MP0003635_abnormal_synaptic_transmissio0.83498451
123MP0002734_abnormal_mechanical_nocicepti0.83423623
124MP0002184_abnormal_innervation0.82635333
125MP0001963_abnormal_hearing_physiology0.82523776
126MP0000653_abnormal_sex_gland0.82244183
127MP0001986_abnormal_taste_sensitivity0.81996679
128MP0004142_abnormal_muscle_tone0.81876260
129MP0002234_abnormal_pharynx_morphology0.81507673
130MP0002736_abnormal_nociception_after0.81495730
131MP0002084_abnormal_developmental_patter0.80642500
132MP0002152_abnormal_brain_morphology0.80378971
133MP0002095_abnormal_skin_pigmentation0.80161696
134MP0001984_abnormal_olfaction0.80059655
135MP0003786_premature_aging0.79157989
136MP0003123_paternal_imprinting0.77916475
137MP0001286_abnormal_eye_development0.77547122
138MP0000762_abnormal_tongue_morphology0.77445103
139MP0000465_gastrointestinal_hemorrhage0.76626344
140MP0003950_abnormal_plasma_membrane0.75286815
141MP0002249_abnormal_larynx_morphology0.73398632
142MP0002116_abnormal_craniofacial_bone0.73384651
143MP0000470_abnormal_stomach_morphology0.71686056
144MP0003121_genomic_imprinting0.70941021
145MP0005394_taste/olfaction_phenotype0.70385956
146MP0005499_abnormal_olfactory_system0.70385956
147MP0002177_abnormal_outer_ear0.68438130
148MP0005380_embryogenesis_phenotype0.68226135
149MP0001672_abnormal_embryogenesis/_devel0.68226135
150MP0002932_abnormal_joint_morphology0.68048011
151MP0000490_abnormal_crypts_of0.67822803
152MP0000026_abnormal_inner_ear0.67307682
153* MP0002398_abnormal_bone_marrow0.67138085
154MP0001873_stomach_inflammation0.66865459
155MP0003828_pulmonary_edema0.66763792
156MP0005410_abnormal_fertilization0.65761073
157MP0002114_abnormal_axial_skeleton0.64688325
158MP0003698_abnormal_male_reproductive0.64485176

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.25639627
2Abnormality of cells of the erythroid lineage (HP:0012130)4.12372837
3Pancreatic cysts (HP:0001737)3.85142584
4Parakeratosis (HP:0001036)3.81013607
5Pancreatic fibrosis (HP:0100732)3.76295572
6True hermaphroditism (HP:0010459)3.43472895
7Abnormal number of erythroid precursors (HP:0012131)3.41661262
8Pendular nystagmus (HP:0012043)3.38562850
9Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.38318511
10Asplenia (HP:0001746)3.37889640
11Breast hypoplasia (HP:0003187)3.29364338
12Aplasia/Hypoplasia of the spleen (HP:0010451)3.27308774
13Macrocytic anemia (HP:0001972)3.21107243
14Molar tooth sign on MRI (HP:0002419)3.14724306
15Abnormality of midbrain morphology (HP:0002418)3.14724306
16Congenital stationary night blindness (HP:0007642)3.14512165
17Birth length less than 3rd percentile (HP:0003561)3.08499560
18Nephronophthisis (HP:0000090)2.95917618
19Cerebral hypomyelination (HP:0006808)2.86494402
20Pallor (HP:0000980)2.83078920
21Increased hepatocellular lipid droplets (HP:0006565)2.74908556
22Stenosis of the external auditory canal (HP:0000402)2.71682325
23Hyperventilation (HP:0002883)2.66555482
24Double outlet right ventricle (HP:0001719)2.62553009
25Congenital malformation of the right heart (HP:0011723)2.62553009
26Abolished electroretinogram (ERG) (HP:0000550)2.60449156
27Abnormality of the labia minora (HP:0012880)2.56515673
28Adrenal hypoplasia (HP:0000835)2.55350716
29Supernumerary spleens (HP:0009799)2.53870542
30Abnormality of the renal medulla (HP:0100957)2.46684873
31Hypoplastic pelvis (HP:0008839)2.42105037
32Optic nerve hypoplasia (HP:0000609)2.40118509
33Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.39904472
34Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.36441685
35Colon cancer (HP:0003003)2.36198223
36Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.36175560
37Short 1st metacarpal (HP:0010034)2.36175560
38Facial hemangioma (HP:0000329)2.33837348
39Congenital ichthyosiform erythroderma (HP:0007431)2.32911448
40Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.32897558
41Sclerocornea (HP:0000647)2.32738095
42Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.31778658
43Degeneration of the lateral corticospinal tracts (HP:0002314)2.31778658
44Aplasia/Hypoplasia of the tibia (HP:0005772)2.29112494
45Esophageal atresia (HP:0002032)2.27898581
463-Methylglutaconic aciduria (HP:0003535)2.27631534
47Acute necrotizing encephalopathy (HP:0006965)2.27469488
48Concave nail (HP:0001598)2.23759244
49Chorioretinal atrophy (HP:0000533)2.23642433
50Attenuation of retinal blood vessels (HP:0007843)2.22183559
51Absent radius (HP:0003974)2.20883713
52Tubular atrophy (HP:0000092)2.19741288
53Abnormality of glycolysis (HP:0004366)2.18927276
54Increased serum pyruvate (HP:0003542)2.18927276
55Mitochondrial inheritance (HP:0001427)2.18193045
56Increased CSF lactate (HP:0002490)2.17312859
57Abnormality of the 1st metacarpal (HP:0010009)2.16645496
58Abnormality of the preputium (HP:0100587)2.16617058
59Lipid accumulation in hepatocytes (HP:0006561)2.16116305
60Cystic liver disease (HP:0006706)2.14143072
61Absent rod-and cone-mediated responses on ERG (HP:0007688)2.13342649
62Dynein arm defect of respiratory motile cilia (HP:0012255)2.13136427
63Absent/shortened dynein arms (HP:0200106)2.13136427
64Medial flaring of the eyebrow (HP:0010747)2.13035280
65Type II lissencephaly (HP:0007260)2.12707674
66Short hallux (HP:0010109)2.12399486
67Abnormal respiratory epithelium morphology (HP:0012253)2.11572617
68Abnormal respiratory motile cilium morphology (HP:0005938)2.11572617
69Acute encephalopathy (HP:0006846)2.11431036
70Patellar aplasia (HP:0006443)2.09692479
71Anomalous pulmonary venous return (HP:0010772)2.09386278
72Exertional dyspnea (HP:0002875)2.08958303
73Aplasia/Hypoplasia of the sacrum (HP:0008517)2.08553617
74Abnormal rod and cone electroretinograms (HP:0008323)2.07557496
75Chin dimple (HP:0010751)2.07344054
76Genetic anticipation (HP:0003743)2.05965658
77Furrowed tongue (HP:0000221)2.05816725
78Absent forearm bone (HP:0003953)2.05439036
79Aplasia involving forearm bones (HP:0009822)2.05439036
80Short tibia (HP:0005736)2.03878067
81Triphalangeal thumb (HP:0001199)2.02868324
82Abnormality of the renal cortex (HP:0011035)2.02043994
83Aplasia/Hypoplasia of the hallux (HP:0008362)2.01534987
84Horseshoe kidney (HP:0000085)2.01221579
85Aplasia/Hypoplasia of the patella (HP:0006498)2.01003303
86Bony spicule pigmentary retinopathy (HP:0007737)1.98949188
87Oligodactyly (hands) (HP:0001180)1.98418148
88Abnormal lung lobation (HP:0002101)1.97842596
89Chronic hepatic failure (HP:0100626)1.97780785
90Renal Fanconi syndrome (HP:0001994)1.97348140
91Small epiphyses (HP:0010585)1.97343260
92Sensory axonal neuropathy (HP:0003390)1.96962635
93Adactyly (HP:0009776)1.96908109
94Male pseudohermaphroditism (HP:0000037)1.95747935
95Absent septum pellucidum (HP:0001331)1.94889989
96Abnormality of the phalanges of the 2nd finger (HP:0009541)1.94233444
97Abnormality of the septum pellucidum (HP:0007375)1.92390472
98Congenital, generalized hypertrichosis (HP:0004540)1.91489267
99Broad-based gait (HP:0002136)1.89991595
100Chromsome breakage (HP:0040012)1.89231516
101Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88980868
102Abnormality of alanine metabolism (HP:0010916)1.88980868
103Hyperalaninemia (HP:0003348)1.88980868
104Hypoparathyroidism (HP:0000829)1.87915591
105Abnormality of placental membranes (HP:0011409)1.87550250
106Amniotic constriction ring (HP:0009775)1.87550250
107Abnormality of the fetal cardiovascular system (HP:0010948)1.86796887
108Abnormal umbilical cord blood vessels (HP:0011403)1.86796887
109Single umbilical artery (HP:0001195)1.86796887
110Abnormality of the proximal phalanges of the hand (HP:0009834)1.86382286
111Inability to walk (HP:0002540)1.86359521
112Short phalanx of the thumb (HP:0009660)1.86231720
113Intestinal atresia (HP:0011100)1.84917326
114Hypoplasia of the capital femoral epiphysis (HP:0003090)1.83880871
115Optic disc pallor (HP:0000543)1.83512839
116Ectopic kidney (HP:0000086)1.82888308
117Abnormality of the pulmonary veins (HP:0011718)1.82814887
118Decreased central vision (HP:0007663)1.81483631
119Rough bone trabeculation (HP:0100670)1.81315960
120Aplasia/Hypoplasia of the tongue (HP:0010295)1.80999292
121Upper limb muscle weakness (HP:0003484)1.80173433
122Progressive external ophthalmoplegia (HP:0000590)1.80168284
123Dandy-Walker malformation (HP:0001305)1.79851605
124Abnormality of DNA repair (HP:0003254)1.79753749
125Abnormality of the ileum (HP:0001549)1.79541541
126Irregular epiphyses (HP:0010582)1.78554365
127Hepatocellular necrosis (HP:0001404)1.77948232
128Lissencephaly (HP:0001339)1.77332846
129Cupped ear (HP:0000378)1.75023122
130Abnormality of the parietal bone (HP:0002696)1.74789397
131Abnormal auditory evoked potentials (HP:0006958)1.74587540
132Preaxial hand polydactyly (HP:0001177)1.74166408
133Aplastic anemia (HP:0001915)1.74084122
134Progressive cerebellar ataxia (HP:0002073)1.73604621
135Small hand (HP:0200055)1.73452864
136Abnormal ciliary motility (HP:0012262)1.73246447
137Keratoconus (HP:0000563)1.73092601
138Increased corneal curvature (HP:0100692)1.73092601
139Absent epiphyses (HP:0010577)1.72922402
140Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.72922402
141Progressive macrocephaly (HP:0004481)1.72506151
142Hyperglycinuria (HP:0003108)1.71899713
143Duplicated collecting system (HP:0000081)1.71758988
144Chronic mucocutaneous candidiasis (HP:0002728)1.71454425
145Recurrent cutaneous fungal infections (HP:0011370)1.71454425
146Gait imbalance (HP:0002141)1.71284248
147Absent thumb (HP:0009777)1.69611596
148Microtia (HP:0008551)1.69147559
149Meckel diverticulum (HP:0002245)1.68858641
150Aplasia/Hypoplasia of the uvula (HP:0010293)1.68402737
151Congenital hepatic fibrosis (HP:0002612)1.67952584
152Abnormal drinking behavior (HP:0030082)1.67639709
153Polydipsia (HP:0001959)1.67639709
154Short thumb (HP:0009778)1.66407452
155Anophthalmia (HP:0000528)1.66229812
156Retinal dysplasia (HP:0007973)1.65780682
157Conical tooth (HP:0000698)1.65111143
158Abnormality of the renal collecting system (HP:0004742)1.63872246
159Leukodystrophy (HP:0002415)1.63127376
160Abnormal number of incisors (HP:0011064)1.60752791
161Rib fusion (HP:0000902)1.60555924
162Cleft eyelid (HP:0000625)1.59853394
163Anencephaly (HP:0002323)1.59719154
164Septo-optic dysplasia (HP:0100842)1.59199769
165Abnormal mitochondria in muscle tissue (HP:0008316)1.59120692
166Abnormality of chromosome stability (HP:0003220)1.59070454
167Sparse lateral eyebrow (HP:0005338)1.59030651
168Atresia of the external auditory canal (HP:0000413)1.58956999
169Anhidrosis (HP:0000970)1.58848403
170Chromosomal breakage induced by crosslinking agents (HP:0003221)1.58570235

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.78324476
2BUB13.45306498
3ZAK3.02782432
4STK392.95270995
5DYRK32.53475370
6WNK32.44750350
7MST42.43654668
8ACVR1B2.37706697
9NME22.34260225
10PNCK2.32702358
11WEE12.28897937
12CDC72.15946589
13GRK12.15714425
14DYRK22.10056684
15VRK11.99290123
16MKNK11.97264940
17PBK1.96500270
18STK161.94847636
19SRPK11.90835735
20MAP4K21.76287246
21TNIK1.72895841
22CDK81.72778741
23MAPK151.65030361
24MAPKAPK51.63724469
25TTK1.62884789
26BMPR1B1.56454850
27BCR1.54105387
28CHEK21.54058194
29TLK11.51218861
30CSNK1G31.46339483
31MKNK21.44262027
32NLK1.42894794
33CDK71.39488846
34INSRR1.37741490
35TSSK61.33889560
36FGR1.28103952
37OXSR11.27482446
38NME11.27457923
39PLK41.26010184
40PLK21.25800291
41CSNK1G11.25147575
42DAPK21.24532407
43PLK31.21763819
44MAP3K121.21208790
45TAF11.18847696
46NEK21.18784095
47STK101.18728800
48PLK11.15478273
49MELK1.14340318
50CDK191.14004843
51MAP3K41.13988414
52CLK11.13762377
53PINK11.13580788
54MAP2K21.06878887
55MAP3K101.04786623
56MOS1.04523875
57BMPR21.03849853
58ADRBK11.03658028
59BRSK21.03447293
60CAMK1D1.02989288
61CDK30.99392150
62PRKCG0.98807111
63CAMK1G0.96682438
64RPS6KA50.96562334
65CASK0.94936041
66MAP2K70.94029629
67IRAK40.93963039
68TGFBR10.93472689
69AURKB0.93461975
70CDK90.93272270
71CSNK1A1L0.91834257
72MAPK130.89532938
73PKN10.88390922
74ADRBK20.86133908
75UHMK10.84202076
76RPS6KB20.83039549
77LIMK10.82597156
78KIT0.82321212
79AURKA0.81679737
80BRD40.80599259
81STK110.75682551
82TAOK30.74712892
83PRKCI0.74273758
84PAK30.73236589
85TESK20.70071336
86PIM20.69870553
87CSNK1G20.69476570
88TRIM280.68668847
89PAK10.67982651
90RAF10.67432769
91STK30.67034450
92ARAF0.66601953
93AKT30.64486543
94DYRK1A0.62864240
95CDK120.62056157
96ATR0.61672620
97TNK20.61411123
98EPHB10.60881353
99MAP3K60.60051920
100NUAK10.60012659
101CSNK2A20.59391747
102* CHEK10.58286803
103ROCK20.58153080
104STK40.57643429
105LATS20.54113359
106MARK10.54064355
107MAP3K80.53954883
108ATM0.53952177
109PRKCE0.51712668
110PRKD20.51312962
111SIK20.50868353
112STK38L0.50798516
113MARK20.50704458
114EPHA40.50482383
115SGK20.50117616
116GRK60.49617390
117PDK20.48815184
118MARK30.48664514
119YES10.48308674
120NTRK30.47420113
121NTRK20.47256584
122SGK4940.47236361
123SGK2230.47236361
124ABL20.46374372
125WNK10.46119597
126PRKCZ0.46082969
127RPS6KA60.45547262
128VRK20.43019378
129CDK11A0.42522299
130RPS6KA40.42314359
131WNK40.41887258
132LCK0.41383420
133GRK70.40932675
134CSNK1E0.40807754
135CDK20.40807661
136CSNK1D0.40654450
137CSNK2A10.40004932
138CDK140.39089353
139PIM10.38904248
140* CDK10.38889927
141GRK50.38702245
142PRKACA0.38478488
143CCNB10.38442343
144PTK2B0.38132327
145MAPK40.37663581
146IKBKB0.37662016
147CAMK10.37084287
148CSNK1A10.35200044
149TEC0.35057665

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.56229216
2RNA polymerase_Homo sapiens_hsa030203.52265479
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.53715612
4Selenocompound metabolism_Homo sapiens_hsa004502.46091256
5Basal transcription factors_Homo sapiens_hsa030222.45247535
6Spliceosome_Homo sapiens_hsa030402.42107100
7Proteasome_Homo sapiens_hsa030502.40417058
8Mismatch repair_Homo sapiens_hsa034302.23604372
9Oxidative phosphorylation_Homo sapiens_hsa001902.22350414
10DNA replication_Homo sapiens_hsa030302.20745941
11Homologous recombination_Homo sapiens_hsa034402.16364163
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.15887087
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.11665958
14Phototransduction_Homo sapiens_hsa047442.09171432
15Nicotine addiction_Homo sapiens_hsa050332.08824270
16Protein export_Homo sapiens_hsa030602.02994471
17Nucleotide excision repair_Homo sapiens_hsa034201.96029432
18Cell cycle_Homo sapiens_hsa041101.92477919
19Parkinsons disease_Homo sapiens_hsa050121.91062207
20Non-homologous end-joining_Homo sapiens_hsa034501.89612631
21Fanconi anemia pathway_Homo sapiens_hsa034601.89435158
22RNA transport_Homo sapiens_hsa030131.88563367
23Nitrogen metabolism_Homo sapiens_hsa009101.80025444
24RNA degradation_Homo sapiens_hsa030181.79143707
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.78878473
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.76382135
27Sulfur relay system_Homo sapiens_hsa041221.75120699
28Huntingtons disease_Homo sapiens_hsa050161.60515864
29Ether lipid metabolism_Homo sapiens_hsa005651.60311675
30One carbon pool by folate_Homo sapiens_hsa006701.48477870
31Pyrimidine metabolism_Homo sapiens_hsa002401.46210952
32Alzheimers disease_Homo sapiens_hsa050101.41167339
33Base excision repair_Homo sapiens_hsa034101.37338361
34Primary immunodeficiency_Homo sapiens_hsa053401.36069039
35Morphine addiction_Homo sapiens_hsa050321.30514753
36mRNA surveillance pathway_Homo sapiens_hsa030151.30421187
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.28897712
38Butanoate metabolism_Homo sapiens_hsa006501.26665612
39Linoleic acid metabolism_Homo sapiens_hsa005911.18905508
40Taste transduction_Homo sapiens_hsa047421.11781266
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11021261
42p53 signaling pathway_Homo sapiens_hsa041151.10652582
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.04658321
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03320830
45Sphingolipid metabolism_Homo sapiens_hsa006000.99517706
46Vitamin B6 metabolism_Homo sapiens_hsa007500.98827002
47Epstein-Barr virus infection_Homo sapiens_hsa051690.97068935
48Steroid biosynthesis_Homo sapiens_hsa001000.95331394
49Olfactory transduction_Homo sapiens_hsa047400.89058976
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88698801
51Circadian entrainment_Homo sapiens_hsa047130.86051387
52Purine metabolism_Homo sapiens_hsa002300.84999429
53Glutamatergic synapse_Homo sapiens_hsa047240.84947349
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83605192
55Dorso-ventral axis formation_Homo sapiens_hsa043200.83317178
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82021658
57Sulfur metabolism_Homo sapiens_hsa009200.81853057
58Autoimmune thyroid disease_Homo sapiens_hsa053200.80958055
59GABAergic synapse_Homo sapiens_hsa047270.80274060
60Asthma_Homo sapiens_hsa053100.80249455
61Arachidonic acid metabolism_Homo sapiens_hsa005900.80021281
62Tryptophan metabolism_Homo sapiens_hsa003800.78984310
63Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75726882
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75623870
65NF-kappa B signaling pathway_Homo sapiens_hsa040640.74947812
66Allograft rejection_Homo sapiens_hsa053300.74865548
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74127280
68Peroxisome_Homo sapiens_hsa041460.72588689
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72035727
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70990706
71Propanoate metabolism_Homo sapiens_hsa006400.70530141
72Oocyte meiosis_Homo sapiens_hsa041140.69037787
73Axon guidance_Homo sapiens_hsa043600.67086948
74Insulin secretion_Homo sapiens_hsa049110.65419316
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63724422
76MicroRNAs in cancer_Homo sapiens_hsa052060.63376820
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63160862
78Hedgehog signaling pathway_Homo sapiens_hsa043400.62261143
79Hematopoietic cell lineage_Homo sapiens_hsa046400.61383643
80Retinol metabolism_Homo sapiens_hsa008300.61088832
81Chemical carcinogenesis_Homo sapiens_hsa052040.61024912
82Renal cell carcinoma_Homo sapiens_hsa052110.60327505
83Graft-versus-host disease_Homo sapiens_hsa053320.60231372
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59055540
85Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58923936
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.58139577
87Herpes simplex infection_Homo sapiens_hsa051680.57315566
88Basal cell carcinoma_Homo sapiens_hsa052170.56840557
89Folate biosynthesis_Homo sapiens_hsa007900.56776921
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56676970
91TGF-beta signaling pathway_Homo sapiens_hsa043500.56350513
92Ovarian steroidogenesis_Homo sapiens_hsa049130.54739997
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54166969
94Fatty acid biosynthesis_Homo sapiens_hsa000610.53664304
95Cocaine addiction_Homo sapiens_hsa050300.53590289
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53140193
97Metabolic pathways_Homo sapiens_hsa011000.52972072
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52388020
99Cardiac muscle contraction_Homo sapiens_hsa042600.52305119
100Antigen processing and presentation_Homo sapiens_hsa046120.51716532
101Serotonergic synapse_Homo sapiens_hsa047260.51670188
102T cell receptor signaling pathway_Homo sapiens_hsa046600.51044004
103Systemic lupus erythematosus_Homo sapiens_hsa053220.50625194
104Cholinergic synapse_Homo sapiens_hsa047250.48422780
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48421648
106HTLV-I infection_Homo sapiens_hsa051660.48149800
107Viral carcinogenesis_Homo sapiens_hsa052030.47698152
108Pathways in cancer_Homo sapiens_hsa052000.47562612
109NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47191488
110Dopaminergic synapse_Homo sapiens_hsa047280.47058603
111Colorectal cancer_Homo sapiens_hsa052100.45306169
112Wnt signaling pathway_Homo sapiens_hsa043100.44774305
113Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.44566620
114Ras signaling pathway_Homo sapiens_hsa040140.44196729
115Vitamin digestion and absorption_Homo sapiens_hsa049770.44137050
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43405073
117Hippo signaling pathway_Homo sapiens_hsa043900.42744170
118Alcoholism_Homo sapiens_hsa050340.42247351
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42156467
120Glycerolipid metabolism_Homo sapiens_hsa005610.40642144
121Small cell lung cancer_Homo sapiens_hsa052220.39450059
122ABC transporters_Homo sapiens_hsa020100.39360346
123Collecting duct acid secretion_Homo sapiens_hsa049660.38997929
124Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38688270
125Regulation of autophagy_Homo sapiens_hsa041400.38553753
126Tight junction_Homo sapiens_hsa045300.37895745
127Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37886865
128Calcium signaling pathway_Homo sapiens_hsa040200.37491599
129Prostate cancer_Homo sapiens_hsa052150.37394810
130Rheumatoid arthritis_Homo sapiens_hsa053230.36745241
131Hepatitis B_Homo sapiens_hsa051610.36687608
132Notch signaling pathway_Homo sapiens_hsa043300.35713350
133Cysteine and methionine metabolism_Homo sapiens_hsa002700.35424765
134Fat digestion and absorption_Homo sapiens_hsa049750.34220859
135Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.34064130
136Sphingolipid signaling pathway_Homo sapiens_hsa040710.32385531
137Pancreatic cancer_Homo sapiens_hsa052120.31355311
138Glutathione metabolism_Homo sapiens_hsa004800.31254615
139Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31202484
140MAPK signaling pathway_Homo sapiens_hsa040100.31090869
141Histidine metabolism_Homo sapiens_hsa003400.30799609
142Long-term depression_Homo sapiens_hsa047300.30716831
143B cell receptor signaling pathway_Homo sapiens_hsa046620.29303366
144African trypanosomiasis_Homo sapiens_hsa051430.28814857
145Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28637729
146Melanoma_Homo sapiens_hsa052180.27256164
147Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.26247135

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