IMPDH1P10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of vitamin D biosynthetic process (GO:0060556)6.33162354
2regulation of podosome assembly (GO:0071801)5.43304347
3regulation of vitamin metabolic process (GO:0030656)5.01674716
4negative regulation of interleukin-12 production (GO:0032695)4.87876181
5positive regulation of chemokine biosynthetic process (GO:0045080)4.86018602
6regulation of interleukin-12 biosynthetic process (GO:0045075)4.76059629
7defense response to protozoan (GO:0042832)4.63516630
8regulation of chemokine biosynthetic process (GO:0045073)4.43479279
9response to protozoan (GO:0001562)4.32489136
10response to peptidoglycan (GO:0032494)4.23285707
11myeloid dendritic cell differentiation (GO:0043011)4.15834738
12negative regulation of cell killing (GO:0031342)4.09586321
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.09586321
14positive regulation of gamma-delta T cell activation (GO:0046645)4.05923197
15regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)4.03847816
16positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)4.03847816
17macrophage activation involved in immune response (GO:0002281)4.00836190
18negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.91004249
19modulation of growth of symbiont involved in interaction with host (GO:0044144)3.91004249
20regulation of growth of symbiont in host (GO:0044126)3.91004249
21negative regulation of growth of symbiont in host (GO:0044130)3.91004249
22positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.89932004
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.88871060
24cellular response to type I interferon (GO:0071357)3.83947086
25type I interferon signaling pathway (GO:0060337)3.83947086
26myeloid dendritic cell activation (GO:0001773)3.83821964
27regulation of T-helper 1 cell differentiation (GO:0045625)3.83329940
28neutrophil activation involved in immune response (GO:0002283)3.79063574
29response to type I interferon (GO:0034340)3.78002901
30leukocyte aggregation (GO:0070486)3.76829473
31interferon-gamma-mediated signaling pathway (GO:0060333)3.73937968
32regulation of interleukin-12 production (GO:0032655)3.72681647
33modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.72212812
34modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.72212812
35positive regulation by organism of defense response of other organism involved in symbiotic interact3.72212812
36modulation by symbiont of host immune response (GO:0052553)3.72212812
37positive regulation by symbiont of host defense response (GO:0052509)3.72212812
38modulation by symbiont of host defense response (GO:0052031)3.72212812
39positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.65277971
40regulation of interferon-alpha production (GO:0032647)3.64372366
41regulation of interleukin-1 beta secretion (GO:0050706)3.63825972
42negative regulation of interleukin-17 production (GO:0032700)3.59671448
43regulation of dendritic cell antigen processing and presentation (GO:0002604)3.59568883
44lipopolysaccharide-mediated signaling pathway (GO:0031663)3.57447226
45positive regulation of interleukin-1 beta secretion (GO:0050718)3.57133810
46negative regulation of cytokine production involved in immune response (GO:0002719)3.54112739
47positive regulation of interleukin-12 production (GO:0032735)3.53263681
48immunoglobulin mediated immune response (GO:0016064)3.50088843
49regulation of chronic inflammatory response (GO:0002676)3.44817228
50positive regulation of type 2 immune response (GO:0002830)3.44739218
51positive regulation of isotype switching (GO:0045830)3.42265763
52regulation of interferon-beta biosynthetic process (GO:0045357)3.37998586
53positive regulation of interferon-alpha production (GO:0032727)3.35601087
54positive regulation of interleukin-1 secretion (GO:0050716)3.33943885
55germinal center formation (GO:0002467)3.31939026
56macrophage activation (GO:0042116)3.25873669
57antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.25353520
58response to interleukin-15 (GO:0070672)3.24028377
59regulation of T-helper 2 cell differentiation (GO:0045628)3.23764041
60negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.21887293
61negative regulation of T-helper cell differentiation (GO:0045623)3.21887293
62regulation of interleukin-1 secretion (GO:0050704)3.21650856
63positive regulation of DNA recombination (GO:0045911)3.15687033
64regulation of regulatory T cell differentiation (GO:0045589)3.15147737
65regulation of membrane protein ectodomain proteolysis (GO:0051043)3.13762147
66regulation of MHC class II biosynthetic process (GO:0045346)3.13759922
67regulation of T cell tolerance induction (GO:0002664)3.13211483
68cellular extravasation (GO:0045123)3.12846426
69regulation of T-helper cell differentiation (GO:0045622)3.12842538
70positive regulation of toll-like receptor signaling pathway (GO:0034123)3.11583745
71regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.09936970
72positive regulation of antigen processing and presentation (GO:0002579)3.08803389
73positive regulation of interleukin-10 production (GO:0032733)3.08118729
74dendritic cell differentiation (GO:0097028)3.08095271
75NIK/NF-kappaB signaling (GO:0038061)3.08039834
76regulation of interleukin-17 production (GO:0032660)3.07923237
77myeloid cell activation involved in immune response (GO:0002275)3.07899074
78positive regulation of B cell mediated immunity (GO:0002714)3.07804147
79positive regulation of immunoglobulin mediated immune response (GO:0002891)3.07804147
80granulocyte activation (GO:0036230)3.07118056
81positive regulation of heat generation (GO:0031652)3.04833736
82antigen processing and presentation of endogenous antigen (GO:0019883)3.03432210
83cellular response to interleukin-15 (GO:0071350)3.02979100
84tolerance induction (GO:0002507)3.02862344
85negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.02246137
86positive regulation of NF-kappaB import into nucleus (GO:0042346)3.01961345
87T cell activation involved in immune response (GO:0002286)3.00677181
88regulation of fever generation (GO:0031620)2.99333050
89positive regulation of defense response to virus by host (GO:0002230)2.99200936
90neutrophil activation (GO:0042119)2.98823161
91positive regulation of interleukin-6 production (GO:0032755)2.98473431
92regulation of antigen processing and presentation (GO:0002577)2.97986080
93positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.97287897
94positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.97005974
95detection of other organism (GO:0098543)2.96483791
96positive regulation of chemokine production (GO:0032722)2.96440197
97antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.95289578
98negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.95092506
99regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.93978385
100response to muramyl dipeptide (GO:0032495)2.93304213

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.08948973
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.18312040
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.95257747
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.91203891
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.27025648
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.06552157
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.76681767
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.43851904
9RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.39533155
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.16557826
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.10860996
12STAT4_19710469_ChIP-ChIP_TH1__Mouse3.10537907
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.08207725
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.98990042
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.85677215
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.76147689
17RUNX_20019798_ChIP-Seq_JUKART_Human2.54525866
18Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.35092912
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.34017080
20MYB_26560356_Chip-Seq_TH2_Human2.33591289
21SMAD_19615063_ChIP-ChIP_OVARY_Human2.31251544
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.21972139
23SPI1_23547873_ChIP-Seq_NB4_Human2.21354278
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.99617514
25VDR_24787735_ChIP-Seq_THP-1_Human1.99171969
26MAF_26560356_Chip-Seq_TH1_Human1.97881935
27VDR_24763502_ChIP-Seq_THP-1_Human1.96911325
28MYB_26560356_Chip-Seq_TH1_Human1.85476888
29SPI1_23127762_ChIP-Seq_K562_Human1.84358727
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.81382113
31FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.78094845
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.72630755
33SCL_19346495_ChIP-Seq_HPC-7_Human1.66350219
34PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.60235643
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.59305847
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.57510182
37GATA3_26560356_Chip-Seq_TH2_Human1.54214302
38CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.53453386
39GATA3_27048872_Chip-Seq_THYMUS_Human1.52905128
40PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.51878817
41GATA1_22025678_ChIP-Seq_K562_Human1.51385254
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50914636
43UTX_26944678_Chip-Seq_JUKART_Human1.43747867
44LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.42969318
45VDR_21846776_ChIP-Seq_THP-1_Human1.41851321
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.36516596
47GATA2_21666600_ChIP-Seq_HMVEC_Human1.31643313
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.30925805
49PU_27001747_Chip-Seq_BMDM_Mouse1.30315435
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.29691607
51LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.28855951
52CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24657391
53NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.23412256
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.21620723
55SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20787873
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20736235
57GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17510868
58MAF_26560356_Chip-Seq_TH2_Human1.17221015
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.16662595
60CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16560907
61CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14750971
62PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13401830
63STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08128778
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.07753012
65TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07647569
66PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04890892
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.03878811
68GATA1_19941827_ChIP-Seq_MEL_Mouse1.03835491
69TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99438316
70STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99283927
71MYC_22102868_ChIP-Seq_BL_Human0.95963294
72PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95650044
73TCF7_22412390_ChIP-Seq_EML_Mouse0.93312455
74GATA1_19941826_ChIP-Seq_K562_Human0.93185330
75VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92932034
76EGR1_19032775_ChIP-ChIP_M12_Human0.83294465
77JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80227699
78ELK3_25401928_ChIP-Seq_HUVEC_Human0.79541862
79KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.77124688
80STAT1_20625510_ChIP-Seq_HELA_Human0.76875916
81GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76376943
82KDM2B_26808549_Chip-Seq_DND41_Human0.76176656
83SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.75792545
84FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.75239293
85BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.73627569
86KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.73345879
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71507772
88GATA1_22383799_ChIP-Seq_G1ME_Mouse0.71387873
89CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70682699
90JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.70593748
91ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.69770021
92BCL6_27268052_Chip-Seq_Bcells_Human0.68560573
93SMRT_27268052_Chip-Seq_Bcells_Human0.67768910
94CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.66756054
95SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.66030161
96TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.64391620
97ESR1_21235772_ChIP-Seq_MCF-7_Human0.63753756
98CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.63650721
99TFEB_21752829_ChIP-Seq_HELA_Human0.62479917
100GATA2_19941826_ChIP-Seq_K562_Human0.62442894

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.81954667
2MP0003303_peritoneal_inflammation4.52278610
3MP0003436_decreased_susceptibility_to4.01510852
4MP0005671_abnormal_response_to3.70223596
5MP0009785_altered_susceptibility_to3.63865100
6MP0002148_abnormal_hypersensitivity_rea3.58898451
7MP0003724_increased_susceptibility_to3.54475396
8MP0005000_abnormal_immune_tolerance3.20539910
9MP0005387_immune_system_phenotype3.13597160
10MP0001790_abnormal_immune_system3.13597160
11MP0006082_CNS_inflammation2.91969711
12MP0001800_abnormal_humoral_immune2.79958605
13MP0002419_abnormal_innate_immunity2.72118575
14MP0005025_abnormal_response_to2.63359007
15MP0002723_abnormal_immune_serum2.52719118
16MP0001873_stomach_inflammation2.51760950
17MP0002452_abnormal_antigen_presenting2.45404210
18MP0009333_abnormal_splenocyte_physiolog2.31122017
19MP0000685_abnormal_immune_system2.26625604
20MP0002420_abnormal_adaptive_immunity2.22315572
21MP0001819_abnormal_immune_cell2.21394838
22MP0010155_abnormal_intestine_physiology2.20983760
23MP0002405_respiratory_system_inflammati2.20522404
24MP0001533_abnormal_skeleton_physiology2.03992238
25MP0009764_decreased_sensitivity_to2.01735237
26MP0004510_myositis1.93595943
27MP0003300_gastrointestinal_ulcer1.87033663
28MP0001845_abnormal_inflammatory_respons1.86531402
29MP0004947_skin_inflammation1.79872639
30MP0005451_abnormal_body_composition1.79170432
31MP0008004_abnormal_stomach_pH1.75812392
32MP0001853_heart_inflammation1.68186618
33MP0008469_abnormal_protein_level1.65379428
34MP0002138_abnormal_hepatobiliary_system1.60822729
35MP0000716_abnormal_immune_system1.59221956
36MP0005310_abnormal_salivary_gland1.56822716
37MP0002398_abnormal_bone_marrow1.52363548
38MP0003448_altered_tumor_morphology1.51639428
39MP0003075_altered_response_to1.50310787
40MP0003763_abnormal_thymus_physiology1.47890901
41MP0005464_abnormal_platelet_physiology1.44705825
42MP0009278_abnormal_bone_marrow1.42353518
43MP0002332_abnormal_exercise_endurance1.40365231
44MP0003172_abnormal_lysosome_physiology1.35016184
45MP0009840_abnormal_foam_cell1.34910595
46MP0005166_decreased_susceptibility_to1.33783077
47MP0000689_abnormal_spleen_morphology1.33099182
48MP0002722_abnormal_immune_system1.27918017
49MP0003195_calcinosis1.27276672
50MP0005058_abnormal_lysosome_morphology1.26289765
51MP0002429_abnormal_blood_cell1.26257833
52MP0005167_abnormal_blood-brain_barrier1.24643425
53MP0000343_altered_response_to1.19711488
54MP0001545_abnormal_hematopoietic_system1.18772622
55MP0005397_hematopoietic_system_phenotyp1.18772622
56MP0001663_abnormal_digestive_system1.18520501
57MP0010307_abnormal_tumor_latency1.15381915
58MP0000858_altered_metastatic_potential1.12418695
59MP0002998_abnormal_bone_remodeling1.12262721
60MP0003866_abnormal_defecation1.11918749
61MP0002254_reproductive_system_inflammat1.09849983
62MP0009765_abnormal_xenobiotic_induced1.05340608
63MP0002933_joint_inflammation1.05335050
64MP0002139_abnormal_hepatobiliary_system1.04802878
65MP0002006_tumorigenesis1.04353674
66MP0003191_abnormal_cellular_cholesterol0.97259508
67MP0005390_skeleton_phenotype0.95030064
68MP0009763_increased_sensitivity_to0.93053450
69MP0001958_emphysema0.91001208
70MP0002166_altered_tumor_susceptibility0.89224974
71MP0003806_abnormal_nucleotide_metabolis0.89037032
72MP0005164_abnormal_response_to0.88019391
73MP0006054_spinal_hemorrhage0.87296756
74MP0000703_abnormal_thymus_morphology0.87203997
75MP0003656_abnormal_erythrocyte_physiolo0.84473656
76MP0000604_amyloidosis0.83716566
77MP0003453_abnormal_keratinocyte_physiol0.80828203
78MP0003091_abnormal_cell_migration0.79991485
79MP0004808_abnormal_hematopoietic_stem0.77791139
80MP0005165_increased_susceptibility_to0.76454541
81MP0001348_abnormal_lacrimal_gland0.75662701
82MP0000465_gastrointestinal_hemorrhage0.74369536
83MP0005381_digestive/alimentary_phenotyp0.73953999
84MP0003950_abnormal_plasma_membrane0.72533025
85MP0003045_fibrosis0.72177965
86MP0002277_abnormal_respiratory_mucosa0.70812136
87MP0003828_pulmonary_edema0.68501849
88MP0008260_abnormal_autophagy0.64938849
89MP0005319_abnormal_enzyme/_coenzyme0.64760605
90MP0004782_abnormal_surfactant_physiolog0.64627057
91MP0003646_muscle_fatigue0.63904237
92MP0003186_abnormal_redox_activity0.63785679
93MP0001542_abnormal_bone_strength0.61471076
94MP0002693_abnormal_pancreas_physiology0.60140447
95MP0003690_abnormal_glial_cell0.58901273
96MP0002132_abnormal_respiratory_system0.57515020
97MP0004883_abnormal_blood_vessel0.54558379
98MP0000249_abnormal_blood_vessel0.53239826
99MP0003795_abnormal_bone_structure0.52451652
100MP0004381_abnormal_hair_follicle0.52237794

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)6.09844276
2Retrobulbar optic neuritis (HP:0100654)5.54569238
3Optic neuritis (HP:0100653)5.54569238
4Myositis (HP:0100614)5.45292748
5Orchitis (HP:0100796)5.37757366
6Abnormality of macrophages (HP:0004311)4.89382309
7Elevated erythrocyte sedimentation rate (HP:0003565)4.66295326
8Recurrent bacterial skin infections (HP:0005406)4.57705166
9Abnormality of glycolipid metabolism (HP:0010969)4.39075029
10Abnormality of liposaccharide metabolism (HP:0010968)4.39075029
11Abnormality of glycosphingolipid metabolism (HP:0004343)4.39075029
12Recurrent abscess formation (HP:0002722)4.34746629
13Eczematoid dermatitis (HP:0000976)4.09272847
14Pulmonary infiltrates (HP:0002113)3.97407514
15Increased IgM level (HP:0003496)3.87985689
16Keratoconjunctivitis sicca (HP:0001097)3.86194704
17T lymphocytopenia (HP:0005403)3.84755538
18Abnormality of T cell number (HP:0011839)3.80553605
19Mediastinal lymphadenopathy (HP:0100721)3.73443299
20Keratoconjunctivitis (HP:0001096)3.67530242
21Recurrent fungal infections (HP:0002841)3.62035057
22Vasculitis (HP:0002633)3.61711681
23Autoimmune thrombocytopenia (HP:0001973)3.60675027
24Gastrointestinal infarctions (HP:0005244)3.56283320
25Gangrene (HP:0100758)3.43771851
26Hemoptysis (HP:0002105)3.42694154
27Abnormal delayed hypersensitivity skin test (HP:0002963)3.41812438
28Meningitis (HP:0001287)3.41403935
29Autoimmune hemolytic anemia (HP:0001890)3.37676671
30Encephalitis (HP:0002383)3.36569748
31Loss of speech (HP:0002371)3.19360916
32Recurrent viral infections (HP:0004429)3.18961300
33Obstructive lung disease (HP:0006536)3.17999382
34Chronic obstructive pulmonary disease (HP:0006510)3.17999382
35Increased serum ferritin (HP:0003281)3.04034102
36Chest pain (HP:0100749)2.99560509
37Recurrent skin infections (HP:0001581)2.96596587
38Abnormality of T cells (HP:0002843)2.95369331
39Arterial thrombosis (HP:0004420)2.91441590
40Recurrent gram-negative bacterial infections (HP:0005420)2.88562723
41Vacuolated lymphocytes (HP:0001922)2.84875399
42Joint swelling (HP:0001386)2.82445120
43Abnormality of the pleura (HP:0002103)2.78059832
44Increased IgE level (HP:0003212)2.73475095
45Dysostosis multiplex (HP:0000943)2.71457504
46Leukocytosis (HP:0001974)2.70008947
47Polyneuropathy (HP:0001271)2.67824175
48Recurrent cutaneous fungal infections (HP:0011370)2.66317324
49Chronic mucocutaneous candidiasis (HP:0002728)2.66317324
50Abnormality of iron homeostasis (HP:0011031)2.63696387
51Pustule (HP:0200039)2.63555882
52Pulmonary embolism (HP:0002204)2.61154366
53Increased cerebral lipofuscin (HP:0011813)2.53800948
54Hypergammaglobulinemia (HP:0010702)2.52827519
55Urticaria (HP:0001025)2.52313054
56Anorexia (HP:0002039)2.51247994
57Disinhibition (HP:0000734)2.42944074
58Abnormality of T cell physiology (HP:0011840)2.42764132
59IgA deficiency (HP:0002720)2.42292811
60Amyloidosis (HP:0011034)2.41713006
61Keratitis (HP:0000491)2.40904748
62IgG deficiency (HP:0004315)2.40614364
63Episodic fever (HP:0001954)2.33766080
64Arthralgia (HP:0002829)2.32924989
65Abnormality of the pericardium (HP:0001697)2.31753566
66Hepatosplenomegaly (HP:0001433)2.31589495
67Spontaneous hematomas (HP:0007420)2.30288745
68Panhypogammaglobulinemia (HP:0003139)2.26048782
69Epistaxis (HP:0000421)2.25348556
70Chronic diarrhea (HP:0002028)2.21598919
71Abnormality of transition element cation homeostasis (HP:0011030)2.21507102
72Glomerulopathy (HP:0100820)2.20305963
73Abnormality of the prostate (HP:0008775)2.19808817
74Abnormality of B cell number (HP:0010975)2.19208534
75Amaurosis fugax (HP:0100576)2.18363382
76Hematochezia (HP:0002573)2.17360820
77Eosinophilia (HP:0001880)2.16159797
78Petechiae (HP:0000967)2.15169233
79Gingivitis (HP:0000230)2.14611840
80Acne (HP:0001061)2.12253484
81Gingival bleeding (HP:0000225)2.11382747
82Increased neuronal autofluorescent lipopigment (HP:0002074)2.10955554
83Vertigo (HP:0002321)2.07907624
84Thrombophlebitis (HP:0004418)2.07145391
85B lymphocytopenia (HP:0010976)2.06822079
86Granulocytopenia (HP:0001913)2.06272931
87Recurrent bronchitis (HP:0002837)2.04280083
88Alveolar cell carcinoma (HP:0006519)2.03135081
89Mutism (HP:0002300)2.02712380
90Purpura (HP:0000979)2.01261394
91Abnormality of polysaccharide metabolism (HP:0011012)2.00954836
92Abnormality of glycosaminoglycan metabolism (HP:0004371)2.00954836
93Abnormality of mucopolysaccharide metabolism (HP:0011020)2.00954836
94Systemic lupus erythematosus (HP:0002725)2.00376806
95Nausea (HP:0002018)1.97975794
96Interstitial pulmonary disease (HP:0006530)1.96562762
97Abnormality of the endocardium (HP:0004306)1.94375055
98Peritonitis (HP:0002586)1.93678351
99Lymphopenia (HP:0001888)1.93228704
100Parakeratosis (HP:0001036)1.93207914

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.43361098
2IRAK34.23906549
3MAP4K13.79470562
4RIPK43.19641239
5IRAK42.96695149
6GRK72.90400038
7BMPR22.77575639
8MAP3K142.70121350
9TYK22.62207892
10TBK12.43429287
11IKBKE2.28771802
12JAK32.27399425
13IKBKB2.22499676
14BLK2.17402626
15CSK2.03052056
16MATK2.01504195
17TAOK21.89431507
18ZAP701.73266816
19SIK31.73222599
20FGR1.65123409
21TAOK11.61628804
22MAP2K31.51247801
23KIT1.48718571
24NME21.47097826
25STK101.45580518
26JAK11.45116739
27ADRBK21.40571266
28MAP3K31.38867233
29PRPF4B1.35178696
30JAK21.33363409
31MAP3K111.32248133
32SYK1.29916181
33BTK1.26605436
34HCK1.21899842
35ACVR1B1.21345340
36DDR21.21195212
37IRAK11.14426809
38IRAK21.12556745
39MOS1.11521823
40TNK21.11057920
41LYN1.09908193
42MARK31.09710610
43LCK1.09195163
44CHUK1.06210545
45ERN11.05460241
46NME11.01863169
47CSF1R1.01151960
48RIPK11.00885792
49MAP3K130.98799828
50ITK0.96931492
51MUSK0.93541257
52FES0.91020394
53TEC0.88893314
54EIF2AK30.88376483
55CDC42BPA0.87457552
56TGFBR20.84456002
57MAP3K10.84298313
58TAOK30.81476761
59MST40.76543977
60TLK10.71918867
61TRPM70.69936486
62MAP3K50.69133263
63EPHB10.65587731
64PDK20.63513808
65PIM20.62933386
66PIM10.62018393
67GRK60.58724923
68MAP2K60.56811894
69TSSK60.54650929
70PRKCQ0.53567764
71MAPK110.53476989
72KSR20.52464748
73PDK10.45906094
74MAPK70.42789130
75ABL10.41590208
76EIF2AK20.40727901
77ABL20.36923311
78MAPKAPK20.33020434
79PDGFRB0.30853579
80MAP3K80.30469950
81CAMKK20.30439855
82MAPK120.28312924
83SIK20.28228586
84WNK10.27693553
85STK240.27340443
86CDK40.25396837
87PDPK10.25184264
88FGFR40.24295704
89PRKCD0.23574440
90MAPK40.21814542
91DAPK20.20035651
92MAPKAPK30.19170586
93RPS6KA60.19052241
94RPS6KL10.18819383
95RPS6KC10.18819383
96MAP3K120.18818590
97PKN10.18520850
98HIPK20.17955755
99TESK20.17843558
100FYN0.17141520

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.67939918
2Allograft rejection_Homo sapiens_hsa053303.67456486
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.99297870
4Autoimmune thyroid disease_Homo sapiens_hsa053202.90572772
5Leishmaniasis_Homo sapiens_hsa051402.79568376
6Type I diabetes mellitus_Homo sapiens_hsa049402.79089640
7Rheumatoid arthritis_Homo sapiens_hsa053232.70427234
8Asthma_Homo sapiens_hsa053102.64216527
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.49285260
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.46843877
11Osteoclast differentiation_Homo sapiens_hsa043802.43852330
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.27277608
13Staphylococcus aureus infection_Homo sapiens_hsa051502.25642008
14NOD-like receptor signaling pathway_Homo sapiens_hsa046212.22840503
15Malaria_Homo sapiens_hsa051442.20031706
16Antigen processing and presentation_Homo sapiens_hsa046122.12797107
17TNF signaling pathway_Homo sapiens_hsa046682.11732769
18African trypanosomiasis_Homo sapiens_hsa051432.07201212
19Measles_Homo sapiens_hsa051622.01251450
20Hematopoietic cell lineage_Homo sapiens_hsa046401.93093067
21Tuberculosis_Homo sapiens_hsa051521.92827598
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.88331561
23Influenza A_Homo sapiens_hsa051641.87486870
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.86337224
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.82654618
26Legionellosis_Homo sapiens_hsa051341.81556940
27Primary immunodeficiency_Homo sapiens_hsa053401.80325738
28T cell receptor signaling pathway_Homo sapiens_hsa046601.73608356
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.67743263
30Toxoplasmosis_Homo sapiens_hsa051451.65877518
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.63801825
32Salmonella infection_Homo sapiens_hsa051321.63458537
33Pertussis_Homo sapiens_hsa051331.54681754
34Herpes simplex infection_Homo sapiens_hsa051681.54225073
35Viral myocarditis_Homo sapiens_hsa054161.46179936
36B cell receptor signaling pathway_Homo sapiens_hsa046621.38760718
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.36877004
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.26324871
39Chemokine signaling pathway_Homo sapiens_hsa040621.25340470
40Other glycan degradation_Homo sapiens_hsa005111.19736891
41Hepatitis B_Homo sapiens_hsa051611.04344622
42Lysosome_Homo sapiens_hsa041421.00129454
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.96947031
44Hepatitis C_Homo sapiens_hsa051600.95488114
45Amoebiasis_Homo sapiens_hsa051460.94206490
46Glycosaminoglycan degradation_Homo sapiens_hsa005310.93299740
47Acute myeloid leukemia_Homo sapiens_hsa052210.88137310
48Epstein-Barr virus infection_Homo sapiens_hsa051690.86417120
49Apoptosis_Homo sapiens_hsa042100.85899584
50Shigellosis_Homo sapiens_hsa051310.85736149
51Phagosome_Homo sapiens_hsa041450.77286710
52Proteasome_Homo sapiens_hsa030500.77224169
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71921883
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71475198
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70059445
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69060955
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67893425
58HTLV-I infection_Homo sapiens_hsa051660.64757008
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61002839
60VEGF signaling pathway_Homo sapiens_hsa043700.60605236
61Prolactin signaling pathway_Homo sapiens_hsa049170.57701349
62Dorso-ventral axis formation_Homo sapiens_hsa043200.52735859
63HIF-1 signaling pathway_Homo sapiens_hsa040660.51489076
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50741292
65Platelet activation_Homo sapiens_hsa046110.46811681
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45850040
67Viral carcinogenesis_Homo sapiens_hsa052030.44855108
68Regulation of autophagy_Homo sapiens_hsa041400.44202349
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.44200819
70Bladder cancer_Homo sapiens_hsa052190.41278812
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.38750477
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38471104
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.38053024
74Prion diseases_Homo sapiens_hsa050200.34558047
75Systemic lupus erythematosus_Homo sapiens_hsa053220.31175568
76Pancreatic cancer_Homo sapiens_hsa052120.30413992
77MAPK signaling pathway_Homo sapiens_hsa040100.29487425
78Type II diabetes mellitus_Homo sapiens_hsa049300.28483685
79Endocytosis_Homo sapiens_hsa041440.25922563
80Sphingolipid metabolism_Homo sapiens_hsa006000.24137334
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.23852464
82Collecting duct acid secretion_Homo sapiens_hsa049660.23796879
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.23394415
84Complement and coagulation cascades_Homo sapiens_hsa046100.22323109
85Insulin resistance_Homo sapiens_hsa049310.21610473
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20305092
87Chronic myeloid leukemia_Homo sapiens_hsa052200.20010699
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.16699958
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.14215439
90GnRH signaling pathway_Homo sapiens_hsa049120.14073893
91FoxO signaling pathway_Homo sapiens_hsa040680.12879713
92Renal cell carcinoma_Homo sapiens_hsa052110.11205047
93Notch signaling pathway_Homo sapiens_hsa043300.11143348
94Non-small cell lung cancer_Homo sapiens_hsa052230.07826200
95Choline metabolism in cancer_Homo sapiens_hsa052310.06248137
96Ovarian steroidogenesis_Homo sapiens_hsa049130.04674221
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.03583323
98Ras signaling pathway_Homo sapiens_hsa040140.02377896
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.00487755
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.00290353

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