ILVBL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene shares similarity with several thiamine pyrophosphate-binding proteins identified in bacteria, yeast, and plants. The highest degree of similarity is found with bacterial acetolactate synthases (AHAS), which are enzymes that catalyze the first step in branched-chain amino acid biosynthesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)5.44995181
2Golgi transport vesicle coating (GO:0048200)5.36210742
3COPI coating of Golgi vesicle (GO:0048205)5.36210742
4protein retention in ER lumen (GO:0006621)5.34466639
5NADH metabolic process (GO:0006734)5.22573988
6proline biosynthetic process (GO:0006561)5.20694922
7maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.17049036
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.97325225
9L-phenylalanine catabolic process (GO:0006559)4.97325225
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.66079556
11L-phenylalanine metabolic process (GO:0006558)4.66079556
12alpha-linolenic acid metabolic process (GO:0036109)4.34095293
13protein maturation by protein folding (GO:0022417)4.28383005
14proline metabolic process (GO:0006560)4.08732921
15very long-chain fatty acid metabolic process (GO:0000038)4.08302693
16GDP-mannose metabolic process (GO:0019673)3.97904271
17low-density lipoprotein particle clearance (GO:0034383)3.93369372
18aromatic amino acid family catabolic process (GO:0009074)3.92698033
19triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.91625166
20retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.88873928
21negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.82468883
224-hydroxyproline metabolic process (GO:0019471)3.78599682
23long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.67511250
24oxaloacetate metabolic process (GO:0006107)3.65180210
25basement membrane organization (GO:0071711)3.61012880
26gluconeogenesis (GO:0006094)3.59308220
27fatty-acyl-CoA biosynthetic process (GO:0046949)3.58415456
28ethanol oxidation (GO:0006069)3.57636123
29glucose 6-phosphate metabolic process (GO:0051156)3.57121740
30heme transport (GO:0015886)3.56466712
31regulation of cholesterol metabolic process (GO:0090181)3.56148268
32monosaccharide biosynthetic process (GO:0046364)3.47178289
33acyl-CoA biosynthetic process (GO:0071616)3.47022466
34thioester biosynthetic process (GO:0035384)3.47022466
35urea cycle (GO:0000050)3.44453623
36central nervous system myelination (GO:0022010)3.44076052
37axon ensheathment in central nervous system (GO:0032291)3.44076052
38hexose biosynthetic process (GO:0019319)3.40769114
39glyoxylate metabolic process (GO:0046487)3.34260093
40fatty-acyl-CoA metabolic process (GO:0035337)3.33816317
41sulfur amino acid catabolic process (GO:0000098)3.33514094
42fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.32107457
43long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.30934066
44regulation of mammary gland epithelial cell proliferation (GO:0033599)3.29597805
45bile acid biosynthetic process (GO:0006699)3.28287205
46ethanol metabolic process (GO:0006067)3.26066008
47reverse cholesterol transport (GO:0043691)3.24664904
48regulation of cholesterol biosynthetic process (GO:0045540)3.23232455
49amyloid precursor protein catabolic process (GO:0042987)3.21088922
50myelin maintenance (GO:0043217)3.20261359
51tricarboxylic acid metabolic process (GO:0072350)3.20055465
52urea metabolic process (GO:0019627)3.19878832
53amyloid precursor protein metabolic process (GO:0042982)3.19360990
54kynurenine metabolic process (GO:0070189)3.18454899
55melanin biosynthetic process (GO:0042438)3.18238442
56UV protection (GO:0009650)3.17696993
57antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.16960644
58antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.16960644
59coenzyme catabolic process (GO:0009109)3.16900082
60glutamine family amino acid biosynthetic process (GO:0009084)3.15889562
61creatine metabolic process (GO:0006600)3.14653757
62high-density lipoprotein particle remodeling (GO:0034375)3.14414249
63regulation of lipoprotein metabolic process (GO:0050746)3.14056161
64regulation of triglyceride catabolic process (GO:0010896)3.12912237
65cofactor catabolic process (GO:0051187)3.12888619
66plasma lipoprotein particle clearance (GO:0034381)3.11546812
67fatty acid beta-oxidation (GO:0006635)3.10955449
68negative regulation of cell size (GO:0045792)3.09815522
69cholesterol biosynthetic process (GO:0006695)3.09033239
70regulation of cholesterol esterification (GO:0010872)3.06466690
71indole-containing compound catabolic process (GO:0042436)3.04525700
72indolalkylamine catabolic process (GO:0046218)3.04525700
73tryptophan catabolic process (GO:0006569)3.04525700
74fatty acid catabolic process (GO:0009062)3.04331885
75acyl-CoA metabolic process (GO:0006637)3.02125379
76thioester metabolic process (GO:0035383)3.02125379
77nitrogen cycle metabolic process (GO:0071941)3.00889006
78cysteine metabolic process (GO:0006534)2.99567465
79lysine metabolic process (GO:0006553)2.97590826
80lysine catabolic process (GO:0006554)2.97590826
81purine ribonucleotide transport (GO:0015868)2.97191845
82regulation of cholesterol homeostasis (GO:2000188)2.94459859
83acetyl-CoA metabolic process (GO:0006084)2.93152050
84response to methylmercury (GO:0051597)2.92363047
85primary alcohol catabolic process (GO:0034310)2.91924892
86negative regulation of cholesterol transport (GO:0032375)2.90515157
87negative regulation of sterol transport (GO:0032372)2.90515157
88positive regulation of lipoprotein lipase activity (GO:0051006)2.90505194
89positive regulation of triglyceride lipase activity (GO:0061365)2.90505194
90phospholipid efflux (GO:0033700)2.89940619
91protein insertion into membrane (GO:0051205)2.89663304
92protein-lipid complex assembly (GO:0065005)2.89205817
93peptidyl-arginine omega-N-methylation (GO:0035247)2.88143037
94fatty acid oxidation (GO:0019395)2.87855842
95aspartate family amino acid catabolic process (GO:0009068)2.87716542
96intestinal cholesterol absorption (GO:0030299)2.87139983
97negative regulation of fibrinolysis (GO:0051918)2.86969638
98cell-cell junction maintenance (GO:0045217)2.86498323
99monocarboxylic acid catabolic process (GO:0072329)2.85670944
100short-chain fatty acid metabolic process (GO:0046459)2.85332073
101lipid oxidation (GO:0034440)2.84972464
102planar cell polarity pathway involved in neural tube closure (GO:0090179)2.84489261
103positive regulation of triglyceride metabolic process (GO:0090208)2.84127077
104barbed-end actin filament capping (GO:0051016)2.83407713
105peptidyl-glutamic acid carboxylation (GO:0017187)2.83277721
106protein carboxylation (GO:0018214)2.83277721
107response to mercury ion (GO:0046689)2.82425240
108bile acid metabolic process (GO:0008206)2.82275388
109tryptophan metabolic process (GO:0006568)2.82192050
110iron coordination entity transport (GO:1901678)2.81296865
111drug transmembrane transport (GO:0006855)2.79909195
112cellular ketone body metabolic process (GO:0046950)2.79224635
113mitotic nuclear envelope reassembly (GO:0007084)2.78817568
114nuclear envelope reassembly (GO:0031468)2.78817568
115melanin metabolic process (GO:0006582)2.77354442
116cholesterol homeostasis (GO:0042632)2.73020718
117amino-acid betaine metabolic process (GO:0006577)2.72795888
118antigen processing and presentation of endogenous antigen (GO:0019883)2.72350406
119macromolecular complex remodeling (GO:0034367)2.72284309
120plasma lipoprotein particle remodeling (GO:0034369)2.72284309
121protein-lipid complex remodeling (GO:0034368)2.72284309
122diacylglycerol metabolic process (GO:0046339)2.72150640
123adenine nucleotide transport (GO:0051503)2.72150481
124plasma lipoprotein particle assembly (GO:0034377)2.71766495
125tyrosine metabolic process (GO:0006570)2.71564791
126endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.71380633
127deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.71166357
128L-serine metabolic process (GO:0006563)2.70530970
129negative regulation of fatty acid biosynthetic process (GO:0045717)2.70445038
130purine nucleotide transport (GO:0015865)2.70352745
131biotin metabolic process (GO:0006768)2.69871489
132sterol biosynthetic process (GO:0016126)2.69623431
133glucose catabolic process (GO:0006007)2.68905397
134cholesterol metabolic process (GO:0008203)2.68853399
135cellular modified amino acid catabolic process (GO:0042219)2.68848598
136opsonization (GO:0008228)2.68788815
137cholesterol efflux (GO:0033344)2.68538179
138apoptotic process involved in morphogenesis (GO:0060561)2.67044790
139peptidyl-proline hydroxylation (GO:0019511)2.65911512
140aromatic amino acid family metabolic process (GO:0009072)2.64911827
141valine metabolic process (GO:0006573)2.64882003
142sterol homeostasis (GO:0055092)2.64782436
143mitochondrial fusion (GO:0008053)2.64613492
144adhesion of symbiont to host cell (GO:0044650)2.64011902
145virion attachment to host cell (GO:0019062)2.64011902
146regulation of fibrinolysis (GO:0051917)2.63045778
147regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.63040361
148maternal placenta development (GO:0001893)2.62140629
149negative regulation of lipase activity (GO:0060192)2.61201889
150flavonoid metabolic process (GO:0009812)2.61000788
151activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.60298450
152aldehyde catabolic process (GO:0046185)2.60114693
153L-serine transport (GO:0015825)2.57862135
154regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.56972353
155serine transport (GO:0032329)2.55633946
156adherens junction assembly (GO:0034333)2.55247993
157positive regulation of nuclease activity (GO:0032075)2.53164146
158desmosome organization (GO:0002934)2.52966716
159pentose-phosphate shunt (GO:0006098)2.50301339
160glycolytic process (GO:0006096)2.50001703
161triglyceride biosynthetic process (GO:0019432)2.48112536
162protein hydroxylation (GO:0018126)2.43202350
163epithelial cell-cell adhesion (GO:0090136)2.42284008
164CDP-diacylglycerol metabolic process (GO:0046341)2.42121310
165regulation of translational fidelity (GO:0006450)2.40970998
166adhesion of symbiont to host (GO:0044406)2.40282051
167positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.40006793
168secondary metabolite biosynthetic process (GO:0044550)2.38429320
169regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.37264914
170mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.36256150
171regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.35969350
172pinocytosis (GO:0006907)2.35942358
173neutral lipid catabolic process (GO:0046461)2.35688006
174acylglycerol catabolic process (GO:0046464)2.35688006
175fructose metabolic process (GO:0006000)2.35153581
176cell-substrate adherens junction assembly (GO:0007045)2.34394710
177focal adhesion assembly (GO:0048041)2.34394710
178peroxisome fission (GO:0016559)2.33853472
179tricarboxylic acid cycle (GO:0006099)2.33414081

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.55139834
2* RXR_22158963_ChIP-Seq_LIVER_Mouse4.56257388
3* PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.22422976
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.01481547
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.53705970
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.45650050
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.04247628
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.79634456
9* FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.68143934
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.46945639
11TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.36725313
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.34883395
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.27782969
14RUNX_20019798_ChIP-Seq_JUKART_Human2.13851716
15PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.04451857
16TET1_21451524_ChIP-Seq_MESCs_Mouse1.99008738
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.98358053
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.96909585
19IRF8_22096565_ChIP-ChIP_GC-B_Human1.93549962
20CLOCK_20551151_ChIP-Seq_293T_Human1.89187354
21NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.87365845
22TP63_17297297_ChIP-ChIP_HaCaT_Human1.86677723
23* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.86478953
24DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.82136232
25* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78890419
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.74690612
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.74100809
28SCL_19346495_ChIP-Seq_HPC-7_Human1.72723618
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.72026394
30P68_20966046_ChIP-Seq_HELA_Human1.70240581
31SRY_22984422_ChIP-ChIP_TESTIS_Rat1.69036695
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.68282670
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.64682808
34CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.64665609
35ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.63281578
36LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.61016621
37JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.59776586
38LXR_22292898_ChIP-Seq_THP-1_Human1.57211540
39MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.56129885
40KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.54232248
41XRN2_22483619_ChIP-Seq_HELA_Human1.53353842
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.52848636
43MYC_18555785_ChIP-Seq_MESCs_Mouse1.52525584
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.52504683
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.51407276
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.49437818
47* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.49215675
48UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.49180940
49CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.45498632
50NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.45165062
51MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.42284426
52ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.41939225
53TRIM28_21343339_ChIP-Seq_HEK293_Human1.41551229
54SA1_27219007_Chip-Seq_ERYTHROID_Human1.40909356
55SMC4_20622854_ChIP-Seq_HELA_Human1.39174277
56SOX2_27498859_Chip-Seq_STOMACH_Mouse1.37382559
57SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37071528
58ZFP281_18757296_ChIP-ChIP_E14_Mouse1.37059499
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.36842090
60NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35078213
61THAP11_20581084_ChIP-Seq_MESCs_Mouse1.34976312
62POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.34431177
63STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.34203345
64CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.34145775
65GATA1_19941826_ChIP-Seq_K562_Human1.34019179
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33946929
67EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33450151
68IRF8_21731497_ChIP-ChIP_J774_Mouse1.32927872
69TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32856382
70VDR_21846776_ChIP-Seq_THP-1_Human1.32240943
71RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.30879106
72ELF1_20517297_ChIP-Seq_JURKAT_Human1.30453737
73CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30407885
74NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.30057710
75CTCF_27219007_Chip-Seq_ERYTHROID_Human1.29063287
76TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.27712298
77SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.26856288
78* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26439996
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25715148
80CTCF_18555785_ChIP-Seq_MESCs_Mouse1.25515619
81KDM2B_26808549_Chip-Seq_K562_Human1.24043540
82IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.24009712
83E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.23633680
84CREB1_26743006_Chip-Seq_LNCaP_Human1.23229494
85ELK3_25401928_ChIP-Seq_HUVEC_Human1.23101048
86MYC_22102868_ChIP-Seq_BL_Human1.23068362
87P63_26484246_Chip-Seq_KERATINOCYTES_Human1.22501441
88MAF_26560356_Chip-Seq_TH1_Human1.21711415
89* ATF3_27146783_Chip-Seq_COLON_Human1.21575589
90KDM2B_26808549_Chip-Seq_DND41_Human1.21389387
91* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.20551277
92TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19938322
93TP53_22127205_ChIP-Seq_IMR90_Human1.19085067
94STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18370171
95* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.17604204
96NELFA_20434984_ChIP-Seq_ESCs_Mouse1.17451740
97FOXO3_23340844_ChIP-Seq_DLD1_Human1.16644877
98TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16290099
99CTCF_27219007_Chip-Seq_Bcells_Human1.15785532
100VDR_24763502_ChIP-Seq_THP-1_Human1.15640328
101IRF8_27001747_Chip-Seq_BMDM_Mouse1.15600999
102GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15484373
103PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.15176386
104SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.14604839
105RARB_24833708_ChIP-Seq_LIVER_Mouse1.14567597
106KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14035140
107SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13389576
108FOXP1_21924763_ChIP-Seq_HESCs_Human1.13085541
109* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.13017491
110DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12891904
111* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12531159
112E2F1_18555785_ChIP-Seq_MESCs_Mouse1.12358101
113GATA1_19941827_ChIP-Seq_MEL_Mouse1.12179623
114ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12108716
115FOXA2_19822575_ChIP-Seq_HepG2_Human1.11968192
116CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11868338
117CTCF_26484167_Chip-Seq_Bcells_Mouse1.11552266
118RARA_24833708_ChIP-Seq_LIVER_Mouse1.10828530
119STAT4_19710469_ChIP-ChIP_TH1__Mouse1.10151382
120MYC_19079543_ChIP-ChIP_MESCs_Mouse1.09335004
121* GABP_19822575_ChIP-Seq_HepG2_Human1.09296780
122SOX2_20726797_ChIP-Seq_SW620_Human1.09040582
123KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08102290
124GATA2_19941826_ChIP-Seq_K562_Human1.07392658
125UTX_26944678_Chip-Seq_JUKART_Human1.06673042
126PHF8_20622854_ChIP-Seq_HELA_Human1.06392956
127HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06038109
128FOXM1_23109430_ChIP-Seq_U2OS_Human1.06021387
129SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03863152
130LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.03612019
131HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.03320151
132GATA2_21666600_ChIP-Seq_HMVEC_Human1.02362363
133GATA3_27048872_Chip-Seq_THYMUS_Human1.02250827
134MYB_26560356_Chip-Seq_TH2_Human1.00832844
135MYB_21317192_ChIP-Seq_ERMYB_Mouse1.00332867
136DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98443172
137EGR1_19032775_ChIP-ChIP_M12_Human0.98421789
138PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98411487
139* RACK7_27058665_Chip-Seq_MCF-7_Human0.98374033
140VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97627368
141* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97189516
142BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96163063
143RUNX1_22412390_ChIP-Seq_EML_Mouse0.95702119
144SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94790513
145SPI1_23127762_ChIP-Seq_K562_Human0.93069658
146SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92716381
147KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92609181
148BCOR_27268052_Chip-Seq_Bcells_Human0.92230806
149* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.91743935
150PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91101796
151* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.91027214
152CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.89738637
153ZNF263_19887448_ChIP-Seq_K562_Human0.89142096
154CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88162084
155GATA1_22025678_ChIP-Seq_K562_Human0.87520316
156SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87410829
157CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.86945720
158MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.86254262
159CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86097796
160SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.85473381
161PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85389327
162TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.84436103
163SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.84409699
164* BCL6_27268052_Chip-Seq_Bcells_Human0.83987324
165GATA4_25053715_ChIP-Seq_YYC3_Human0.83906905
166PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.83022696
167TBX20_22080862_ChIP-Seq_HEART_Mouse0.82140801
168TBX20_22328084_ChIP-Seq_HEART_Mouse0.82140801
169CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.81832994
170KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.80083101
171Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.79883559

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.64841866
2MP0002139_abnormal_hepatobiliary_system4.34172484
3MP0003705_abnormal_hypodermis_morpholog3.95780942
4MP0009840_abnormal_foam_cell3.90393880
5MP0003011_delayed_dark_adaptation3.59355231
6MP0005365_abnormal_bile_salt3.34184382
7MP0005085_abnormal_gallbladder_physiolo3.15995598
8MP0008875_abnormal_xenobiotic_pharmacok3.05594159
9MP0003806_abnormal_nucleotide_metabolis2.89801737
10MP0005171_absent_coat_pigmentation2.86962360
11MP0005257_abnormal_intraocular_pressure2.76426293
12MP0005670_abnormal_white_adipose2.59864940
13MP0001666_abnormal_nutrient_absorption2.44636681
14MP0010030_abnormal_orbit_morphology2.37118085
15MP0010329_abnormal_lipoprotein_level2.31664770
16MP0005083_abnormal_biliary_tract2.31463092
17MP0000751_myopathy2.30406409
18MP0008260_abnormal_autophagy2.27498341
19MP0005058_abnormal_lysosome_morphology2.27343587
20MP0000003_abnormal_adipose_tissue2.24399069
21MP0003329_amyloid_beta_deposits2.21609576
22MP0004858_abnormal_nervous_system2.20282267
23MP0000920_abnormal_myelination2.16988906
24MP0003252_abnormal_bile_duct2.15673706
25MP0003191_abnormal_cellular_cholesterol2.15593565
26MP0004272_abnormal_basement_membrane2.07952393
27MP0005332_abnormal_amino_acid1.92547016
28MP0000604_amyloidosis1.92032869
29MP0004019_abnormal_vitamin_homeostasis1.85251458
30MP0004185_abnormal_adipocyte_glucose1.81693876
31MP0003656_abnormal_erythrocyte_physiolo1.77340975
32MP0004147_increased_porphyrin_level1.69739658
33MP0000685_abnormal_immune_system1.67906030
34MP0002118_abnormal_lipid_homeostasis1.65885502
35MP0003195_calcinosis1.64499332
36MP0001958_emphysema1.63896917
37MP0006082_CNS_inflammation1.62569660
38MP0003690_abnormal_glial_cell1.57838618
39MP0008438_abnormal_cutaneous_collagen1.57739004
40MP0005584_abnormal_enzyme/coenzyme_acti1.57462369
41MP0010234_abnormal_vibrissa_follicle1.53822370
42MP0003950_abnormal_plasma_membrane1.48703098
43MP0003300_gastrointestinal_ulcer1.46720061
44MP0000609_abnormal_liver_physiology1.45830880
45MP0000537_abnormal_urethra_morphology1.44916415
46MP0003566_abnormal_cell_adhesion1.42683634
47MP0005671_abnormal_response_to1.42408669
48MP0005409_darkened_coat_color1.41971189
49MP0004947_skin_inflammation1.40032234
50MP0009643_abnormal_urine_homeostasis1.39246877
51MP0002877_abnormal_melanocyte_morpholog1.39161252
52MP0009785_altered_susceptibility_to1.36228654
53MP0002970_abnormal_white_adipose1.30315101
54MP0002249_abnormal_larynx_morphology1.29748744
55MP0004264_abnormal_extraembryonic_tissu1.28979063
56MP0001661_extended_life_span1.28500704
57MP0003693_abnormal_embryo_hatching1.26773733
58MP0005076_abnormal_cell_differentiation1.25481341
59MP0002089_abnormal_postnatal_growth/wei1.25450940
60MP0002166_altered_tumor_susceptibility1.25052642
61MP0005408_hypopigmentation1.24644418
62MP0009384_cardiac_valve_regurgitation1.22371547
63MP0001835_abnormal_antigen_presentation1.19860327
64MP0005451_abnormal_body_composition1.19765602
65MP0005025_abnormal_response_to1.19743048
66MP0003186_abnormal_redox_activity1.19262806
67MP0004782_abnormal_surfactant_physiolog1.17658985
68MP0003724_increased_susceptibility_to1.15943503
69MP0005464_abnormal_platelet_physiology1.14088835
70MP0003868_abnormal_feces_composition1.13576412
71MP0002933_joint_inflammation1.13172504
72MP0000566_synostosis1.13151335
73MP0000467_abnormal_esophagus_morphology1.12466027
74MP0003136_yellow_coat_color1.10965335
75MP0004381_abnormal_hair_follicle1.10181920
76MP0000462_abnormal_digestive_system1.09774557
77MP0008469_abnormal_protein_level1.08646297
78MP0005319_abnormal_enzyme/_coenzyme1.06594618
79MP0001764_abnormal_homeostasis1.05910333
80MP0001790_abnormal_immune_system1.05372742
81MP0005387_immune_system_phenotype1.05372742
82MP0004233_abnormal_muscle_weight1.04547391
83MP0003763_abnormal_thymus_physiology1.03674948
84MP0009672_abnormal_birth_weight1.02211529
85MP0000750_abnormal_muscle_regeneration1.00275501
86MP0006138_congestive_heart_failure0.99777651
87MP0010155_abnormal_intestine_physiology0.98518038
88MP0003111_abnormal_nucleus_morphology0.98319838
89MP0002796_impaired_skin_barrier0.97690560
90MP0003172_abnormal_lysosome_physiology0.97439704
91MP0000678_abnormal_parathyroid_gland0.97394448
92MP0000372_irregular_coat_pigmentation0.97142002
93MP0005666_abnormal_adipose_tissue0.96213984
94MP0002419_abnormal_innate_immunity0.94857278
95MP0009764_decreased_sensitivity_to0.94334143
96MP0001853_heart_inflammation0.94144245
97MP0003436_decreased_susceptibility_to0.93927919
98MP0000747_muscle_weakness0.93248265
99MP0003315_abnormal_perineum_morphology0.91841125
100MP0003634_abnormal_glial_cell0.89963002
101MP0005000_abnormal_immune_tolerance0.89634275
102MP0001800_abnormal_humoral_immune0.89311752
103MP0003866_abnormal_defecation0.89309532
104MP0003075_altered_response_to0.88717747
105MP0000465_gastrointestinal_hemorrhage0.87819000
106MP0002098_abnormal_vibrissa_morphology0.87675413
107MP0002971_abnormal_brown_adipose0.87220252
108MP0000681_abnormal_thyroid_gland0.86926575
109MP0006036_abnormal_mitochondrial_physio0.85939687
110MP0002723_abnormal_immune_serum0.85450918
111MP0003123_paternal_imprinting0.85372245
112MP0002075_abnormal_coat/hair_pigmentati0.85182325
113MP0005330_cardiomyopathy0.84901771
114MP0004130_abnormal_muscle_cell0.83994715
115MP0001243_abnormal_dermal_layer0.83330122
116MP0009763_increased_sensitivity_to0.83136537
117MP0001216_abnormal_epidermal_layer0.82032764
118MP0001845_abnormal_inflammatory_respons0.81629794
119MP0001348_abnormal_lacrimal_gland0.81034223
120MP0003279_aneurysm0.80691335
121MP0005508_abnormal_skeleton_morphology0.80476237
122MP0002420_abnormal_adaptive_immunity0.80439527
123MP0005636_abnormal_mineral_homeostasis0.79113094
124MP0001819_abnormal_immune_cell0.78519101
125MP0005501_abnormal_skin_physiology0.78325577
126MP0008932_abnormal_embryonic_tissue0.77797700
127MP0000598_abnormal_liver_morphology0.76611573
128MP0000015_abnormal_ear_pigmentation0.76407306
129MP0002452_abnormal_antigen_presenting0.76345838
130MP0001881_abnormal_mammary_gland0.75937568
131MP0000358_abnormal_cell_content/0.75718052
132MP0005075_abnormal_melanosome_morpholog0.75456896
133MP0004087_abnormal_muscle_fiber0.74869395
134MP0009765_abnormal_xenobiotic_induced0.74776345
135MP0010771_integument_phenotype0.74591483
136MP0001186_pigmentation_phenotype0.73751004
137MP0008004_abnormal_stomach_pH0.73432595
138MP0006054_spinal_hemorrhage0.72976880
139MP0000538_abnormal_urinary_bladder0.72797070
140MP0003879_abnormal_hair_cell0.72505421
141MP0001873_stomach_inflammation0.71925357
142MP0000371_diluted_coat_color0.71603957
143MP0002136_abnormal_kidney_physiology0.71451127
144MP0001730_embryonic_growth_arrest0.71334527
145MP0001851_eye_inflammation0.71108035
146MP0001533_abnormal_skeleton_physiology0.70828083
147MP0005375_adipose_tissue_phenotype0.70754619
148MP0000762_abnormal_tongue_morphology0.70142921
149MP0002148_abnormal_hypersensitivity_rea0.69862969
150MP0003453_abnormal_keratinocyte_physiol0.69622379
151MP0009931_abnormal_skin_appearance0.69397273
152MP0005334_abnormal_fat_pad0.69284008
153MP0001849_ear_inflammation0.67473174
154MP0009642_abnormal_blood_homeostasis0.67450655
155MP0005023_abnormal_wound_healing0.67333045
156MP0002822_catalepsy0.67023465
157MP0001765_abnormal_ion_homeostasis0.66808610
158MP0005165_increased_susceptibility_to0.65510221
159MP0000013_abnormal_adipose_tissue0.65211350
160MP0002060_abnormal_skin_morphology0.65055347
161MP0002254_reproductive_system_inflammat0.64601405

Predicted human phenotypes

RankGene SetZ-score
1Xanthomatosis (HP:0000991)4.58718463
2Hyperlipoproteinemia (HP:0010980)4.26954163
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.25223474
4Intrahepatic cholestasis (HP:0001406)3.91521919
5Vertebral compression fractures (HP:0002953)3.91145671
6Deep venous thrombosis (HP:0002625)3.78229907
7Hypoalphalipoproteinemia (HP:0003233)3.48026501
8Distal upper limb amyotrophy (HP:0007149)3.44537293
9Upper limb amyotrophy (HP:0009129)3.44537293
10Vascular calcification (HP:0004934)3.42137056
11Neurofibrillary tangles (HP:0002185)3.35882925
12Abnormality of fatty-acid metabolism (HP:0004359)3.32869889
13Protrusio acetabuli (HP:0003179)3.26448408
14Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.23218199
15Cardiovascular calcification (HP:0011915)3.16865817
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.15974746
17Hypolipoproteinemia (HP:0010981)3.14714195
18Hemorrhage of the eye (HP:0011885)3.01033910
19Abnormality of monocarboxylic acid metabolism (HP:0010996)2.99219424
20Hypobetalipoproteinemia (HP:0003563)2.98667422
21Ulnar bowing (HP:0003031)2.91067208
22Ketosis (HP:0001946)2.88819329
23Ragged-red muscle fibers (HP:0003200)2.87287046
24Hyperacusis (HP:0010780)2.83149811
25Hand muscle atrophy (HP:0009130)2.82914713
26Abnormality of glutamine family amino acid metabolism (HP:0010902)2.75501737
27Hyperammonemia (HP:0001987)2.75296912
28Prolonged partial thromboplastin time (HP:0003645)2.70754527
29Abnormality of aspartate family amino acid metabolism (HP:0010899)2.70504911
30J-shaped sella turcica (HP:0002680)2.67038064
31Amyloidosis (HP:0011034)2.66873097
32Achilles tendon contracture (HP:0001771)2.65860922
33Hypoplasia of the thymus (HP:0000778)2.61695097
34Testicular atrophy (HP:0000029)2.60679652
35Degeneration of the lateral corticospinal tracts (HP:0002314)2.59047536
36Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.59047536
37Distal lower limb muscle weakness (HP:0009053)2.58093470
38Abnormality of glycine metabolism (HP:0010895)2.57333772
39Abnormality of serine family amino acid metabolism (HP:0010894)2.57333772
40Axonal loss (HP:0003447)2.56675324
41Abnormality of sulfur amino acid metabolism (HP:0004339)2.49146183
42Abnormality of the Achilles tendon (HP:0005109)2.48543236
43Hyperglycinuria (HP:0003108)2.47508223
44Back pain (HP:0003418)2.46092884
45Growth hormone excess (HP:0000845)2.44524868
46Microvesicular hepatic steatosis (HP:0001414)2.42212912
47Cerebral inclusion bodies (HP:0100314)2.40472386
48Fat malabsorption (HP:0002630)2.39830164
49Biconcave vertebral bodies (HP:0004586)2.39679307
50Abnormality of glycolysis (HP:0004366)2.39392032
51Elevated erythrocyte sedimentation rate (HP:0003565)2.38341291
52Abnormality of methionine metabolism (HP:0010901)2.37389414
53T lymphocytopenia (HP:0005403)2.33808271
54Vacuolated lymphocytes (HP:0001922)2.30961973
55Prolonged neonatal jaundice (HP:0006579)2.30107272
56Distal lower limb amyotrophy (HP:0008944)2.29931361
57Ketoacidosis (HP:0001993)2.29669855
58Thin bony cortex (HP:0002753)2.27347288
59Mitral stenosis (HP:0001718)2.25810516
60Abnormal gallbladder morphology (HP:0012437)2.25766651
61Premature skin wrinkling (HP:0100678)2.25512676
62Broad distal phalanx of finger (HP:0009836)2.24387033
63Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.24347373
64Ileus (HP:0002595)2.23140664
65Abnormality of glycolipid metabolism (HP:0010969)2.22053116
66Abnormality of liposaccharide metabolism (HP:0010968)2.22053116
67Abnormality of glycosphingolipid metabolism (HP:0004343)2.22053116
68Complement deficiency (HP:0004431)2.21309149
69Epidermoid cyst (HP:0200040)2.21300329
70Parakeratosis (HP:0001036)2.20842156
71Cervical subluxation (HP:0003308)2.18825849
72Cerebral aneurysm (HP:0004944)2.18159758
73Hypoglycemic coma (HP:0001325)2.17867659
74Systemic lupus erythematosus (HP:0002725)2.17856937
75Abnormal gallbladder physiology (HP:0012438)2.17713940
76Cholecystitis (HP:0001082)2.17713940
77Dysostosis multiplex (HP:0000943)2.16925163
78Cholelithiasis (HP:0001081)2.16359781
79Short nail (HP:0001799)2.14062558
80Abnormality of T cell number (HP:0011839)2.13469506
81Increased cerebral lipofuscin (HP:0011813)2.13330837
82Severe combined immunodeficiency (HP:0004430)2.13134363
83Hypercholesterolemia (HP:0003124)2.12821818
84Abnormality of dicarboxylic acid metabolism (HP:0010995)2.12644032
85Dicarboxylic aciduria (HP:0003215)2.12644032
86Increased neuronal autofluorescent lipopigment (HP:0002074)2.12260802
87Peritonitis (HP:0002586)2.10633585
88Hyperbilirubinemia (HP:0002904)2.08062349
89Purpura (HP:0000979)2.07265663
90Generalized aminoaciduria (HP:0002909)2.06236843
91Abnormality of the common coagulation pathway (HP:0010990)2.05342721
92Abnormality of carpal bone ossification (HP:0006257)2.05019861
93Mesangial abnormality (HP:0001966)2.04636636
94Panhypogammaglobulinemia (HP:0003139)2.02149692
95Increased serum pyruvate (HP:0003542)2.01850498
96Mildly elevated creatine phosphokinase (HP:0008180)2.00857160
97Abnormality of mucopolysaccharide metabolism (HP:0011020)2.00012341
98Abnormality of polysaccharide metabolism (HP:0011012)2.00012341
99Abnormality of glycosaminoglycan metabolism (HP:0004371)2.00012341
100Stridor (HP:0010307)1.99946128
101Hyperparathyroidism (HP:0000843)1.98491784
102Abnormality of the corticospinal tract (HP:0002492)1.98033024
103Steatorrhea (HP:0002570)1.97995960
104Hypoplasia of the capital femoral epiphysis (HP:0003090)1.97809305
105Nuclear cataract (HP:0100018)1.97516931
106Urinary glycosaminoglycan excretion (HP:0003541)1.96338001
107Mucopolysacchariduria (HP:0008155)1.96338001
108Onion bulb formation (HP:0003383)1.95386609
109Acanthosis nigricans (HP:0000956)1.94765437
110Gingival bleeding (HP:0000225)1.94393077
111Rhabdomyolysis (HP:0003201)1.91054424
112Abnormality of purine metabolism (HP:0004352)1.90186542
113Joint hemorrhage (HP:0005261)1.90164744
114Hypokinesia (HP:0002375)1.90069025
115Turricephaly (HP:0000262)1.90016912
116Recurrent viral infections (HP:0004429)1.89755034
117Trismus (HP:0000211)1.89541588
118Increased connective tissue (HP:0009025)1.89397650
119Combined immunodeficiency (HP:0005387)1.88320895
120Abnormality of the umbilical cord (HP:0010881)1.87502994
121Myoglobinuria (HP:0002913)1.86575617
122Progressive neurologic deterioration (HP:0002344)1.86162991
123Flattened epiphyses (HP:0003071)1.86118874
124Hypoproteinemia (HP:0003075)1.85673626
125Abnormality of the thoracic spine (HP:0100711)1.85030495
126Long palpebral fissure (HP:0000637)1.84221888
127Opisthotonus (HP:0002179)1.83705120
128Progressive muscle weakness (HP:0003323)1.83162252
129Metabolic acidosis (HP:0001942)1.82270213
130Abnormality of dentin (HP:0010299)1.82062700
131Loss of speech (HP:0002371)1.81832505
132Generalized amyotrophy (HP:0003700)1.80768553
133Neonatal onset (HP:0003623)1.80752933
134Insomnia (HP:0100785)1.80592891
135Mitral regurgitation (HP:0001653)1.80467612
136Increased mean platelet volume (HP:0011877)1.80255792
137Hepatic necrosis (HP:0002605)1.79868131
138Abdominal distention (HP:0003270)1.79574859
139Spinal rigidity (HP:0003306)1.79555970
140Myopathic facies (HP:0002058)1.79141712
141Centrally nucleated skeletal muscle fibers (HP:0003687)1.79041380
142Chronic otitis media (HP:0000389)1.78285431
143Hypertriglyceridemia (HP:0002155)1.76332656
144Exercise-induced myalgia (HP:0003738)1.76225695
145Lethargy (HP:0001254)1.75383093
146Abnormal platelet volume (HP:0011876)1.75343829
147Nonimmune hydrops fetalis (HP:0001790)1.75173269
148B lymphocytopenia (HP:0010976)1.74640737
149Abnormality of B cell number (HP:0010975)1.74640737
150Hydroxyprolinuria (HP:0003080)1.74415739
151Abnormality of proline metabolism (HP:0010907)1.74415739
152Athetosis (HP:0002305)1.73971555
153Nephritis (HP:0000123)1.71773499
154Malnutrition (HP:0004395)1.71174868
155Increased serum ferritin (HP:0003281)1.70761597
156Abnormality of the distal phalanges of the toes (HP:0010182)1.70605263
157Premature rupture of membranes (HP:0001788)1.70048494
158Abnormality of complement system (HP:0005339)1.69546326
159Shallow orbits (HP:0000586)1.69297050
160Fragile skin (HP:0001030)1.68761254
161Skin nodule (HP:0200036)1.68159812
162Absent epiphyses (HP:0010577)1.67941766
163Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.67941766
164Abnormal ossification of hand bones (HP:0005921)1.67880997
165Right ventricular cardiomyopathy (HP:0011663)1.67612896
166Vomiting (HP:0002013)1.66990659
167Flat acetabular roof (HP:0003180)1.66918316
168Increased muscle lipid content (HP:0009058)1.66424123
169Menorrhagia (HP:0000132)1.66390718
170Paraparesis (HP:0002385)1.66322901
171Cerebral edema (HP:0002181)1.66182810
172Elbow flexion contracture (HP:0002987)1.65875108
173Acanthocytosis (HP:0001927)1.65802313
174Myocardial infarction (HP:0001658)1.65459947
175Blue sclerae (HP:0000592)1.64921429
176Difficulty climbing stairs (HP:0003551)1.64835207
177Petechiae (HP:0000967)1.64417052
178Hepatosplenomegaly (HP:0001433)1.64177493
179Bulbar palsy (HP:0001283)1.61943554
180Spastic paraparesis (HP:0002313)1.60694079

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA23.42627243
2ERN13.38846718
3EPHB13.27780461
4MST1R3.24705500
5BCKDK3.18711533
6SMG13.16827184
7STK392.84699506
8ICK2.59871939
9MET2.32442675
10PIM22.28867623
11IRAK32.24090903
12FGFR42.15485912
13OXSR11.92615917
14SIK11.91850598
15MAP4K11.91801462
16TRIB31.86061952
17MAPKAPK51.84182850
18TBK11.75003659
19TYK21.74784170
20PKN21.74395998
21ARAF1.71936761
22PIK3CA1.70647457
23PTK61.66039848
24VRK21.63742010
25PRPF4B1.63289270
26TESK21.61637340
27BUB11.59313036
28KDR1.59014115
29LRRK21.56692023
30NME21.53073700
31PAK41.49667507
32WNK41.47323435
33ITK1.40863987
34KIT1.39185326
35ZAP701.34632268
36TTN1.30024468
37TAOK21.27849050
38PRKD31.26618585
39ABL21.25763760
40CDK191.21621853
41TGFBR21.20458020
42MYLK1.19893421
43PTK21.19347841
44PDK21.17883950
45IKBKE1.16561890
46EPHB21.16526343
47CSF1R1.16503947
48LIMK11.14806136
49STK161.12250021
50RET1.11808309
51FGFR21.10573127
52MAP3K71.10270365
53PRKCQ1.09971322
54STK101.09046356
55BRAF1.08015397
56DDR21.08010078
57LMTK21.06675258
58FLT31.06602479
59BTK1.05873113
60WNK11.04871939
61MAP2K21.03203121
62LCK1.02777738
63GRK61.00129381
64SCYL20.96393431
65MST40.94161429
66TXK0.91506528
67AURKA0.91028867
68PDGFRA0.89686235
69BLK0.88388755
70DAPK30.87812347
71JAK10.87482066
72MAPK110.86874610
73EEF2K0.86169372
74MAP3K30.84878658
75MAP3K130.83228020
76PBK0.83114045
77CDK70.83102559
78RPS6KA20.81944713
79JAK30.80520078
80TNK20.79385537
81PHKG10.79318825
82PHKG20.79318825
83DYRK1B0.78631687
84MTOR0.78016914
85SYK0.77901787
86CSNK1G30.76750769
87MAPK120.76405390
88AKT20.75700632
89PRKD20.75444299
90ILK0.74371720
91DAPK10.74245215
92PDPK10.74007994
93HCK0.73683071
94CSNK1A1L0.72642026
95IRAK20.70922934
96TRPM70.70831650
97PRKD10.69024805
98CSK0.68418224
99PAK30.68104705
100BMX0.65586617
101MAPK40.65514292
102PDGFRB0.65170926
103PKN10.64448172
104PRKCI0.62087658
105TESK10.61046814
106TTK0.60837782
107PDK10.60753919
108FYN0.59490790
109CDC42BPA0.59346471
110MUSK0.58815135
111CDK150.58353467
112PRKCH0.58032450
113CDK11A0.57531067
114ROCK20.57128538
115INSRR0.56806501
116CSNK1G10.56522057
117CAMK2D0.56190981
118CAMK2G0.56088966
119JAK20.55822275
120MAP3K80.55113062
121LATS20.54040965
122MAP3K100.53670948
123PIK3CG0.53125715
124CDK180.52621668
125CDK140.51965587
126LYN0.50795034
127PAK10.50371687
128RPS6KB20.49658035
129NTRK10.49435423
130EPHA30.49394612
131RPS6KL10.49146391
132RPS6KC10.49146391
133SRC0.48865114
134RIPK10.47845613
135INSR0.47568775
136IRAK10.47062874
137TAOK30.46570028
138TNIK0.46005394
139CDK120.45622379
140PAK20.44589783
141PRKG20.44386312
142MAP2K30.44171529
143KSR20.43808297
144MAPKAPK30.43673134
145MARK20.42701525
146BRSK10.42158026
147MAP3K110.41688552
148CAMK2B0.40702263
149NLK0.39583821
150CDK60.38676793
151PRKAA10.34525136
152GSK3A0.33508010
153CCNB10.33331664
154TAOK10.32881840
155NME10.32037435
156STK380.31510836
157CDK40.31151817
158CSNK1G20.30972549

Predicted pathways (KEGG)

RankGene SetZ-score
1Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.57981458
2Fatty acid elongation_Homo sapiens_hsa000623.44512144
3Fatty acid degradation_Homo sapiens_hsa000712.62869060
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.56235728
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.47345551
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.43286310
7Steroid biosynthesis_Homo sapiens_hsa001002.41098457
8Sulfur metabolism_Homo sapiens_hsa009202.39524933
9Fatty acid metabolism_Homo sapiens_hsa012122.37067301
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.35319179
11Nitrogen metabolism_Homo sapiens_hsa009102.31557438
12Butanoate metabolism_Homo sapiens_hsa006502.05417876
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.03530709
14Histidine metabolism_Homo sapiens_hsa003402.02725679
15Tryptophan metabolism_Homo sapiens_hsa003802.02492650
16Propanoate metabolism_Homo sapiens_hsa006401.98858232
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.83422594
18Peroxisome_Homo sapiens_hsa041461.81082985
19PPAR signaling pathway_Homo sapiens_hsa033201.80544055
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.76197071
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.75578632
22Arginine biosynthesis_Homo sapiens_hsa002201.65576234
23Bile secretion_Homo sapiens_hsa049761.61125451
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.59881693
25Complement and coagulation cascades_Homo sapiens_hsa046101.57642408
26Chemical carcinogenesis_Homo sapiens_hsa052041.48420177
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.48193439
28Vibrio cholerae infection_Homo sapiens_hsa051101.47092498
29Pyruvate metabolism_Homo sapiens_hsa006201.45894832
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.45752795
31Caffeine metabolism_Homo sapiens_hsa002321.45567201
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.44752418
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43128906
34Retinol metabolism_Homo sapiens_hsa008301.42663264
35Base excision repair_Homo sapiens_hsa034101.36836799
36beta-Alanine metabolism_Homo sapiens_hsa004101.36052042
37Primary immunodeficiency_Homo sapiens_hsa053401.35360866
38Vitamin B6 metabolism_Homo sapiens_hsa007501.32984982
39Fat digestion and absorption_Homo sapiens_hsa049751.28428817
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.28307125
41Sulfur relay system_Homo sapiens_hsa041221.27005853
42Starch and sucrose metabolism_Homo sapiens_hsa005001.26816730
43N-Glycan biosynthesis_Homo sapiens_hsa005101.21389305
44Central carbon metabolism in cancer_Homo sapiens_hsa052301.20725791
45ABC transporters_Homo sapiens_hsa020101.17940635
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.17204904
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.16177139
48Carbon metabolism_Homo sapiens_hsa012001.12936689
49Vitamin digestion and absorption_Homo sapiens_hsa049771.12189211
50Staphylococcus aureus infection_Homo sapiens_hsa051501.11314449
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10249751
52Folate biosynthesis_Homo sapiens_hsa007901.09260948
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.07933282
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.04473598
55Bladder cancer_Homo sapiens_hsa052191.02692975
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00636811
57Glycerolipid metabolism_Homo sapiens_hsa005610.99092578
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98205106
59Arginine and proline metabolism_Homo sapiens_hsa003300.95732723
60AMPK signaling pathway_Homo sapiens_hsa041520.93682456
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91591014
62Biosynthesis of amino acids_Homo sapiens_hsa012300.90360535
63Pentose phosphate pathway_Homo sapiens_hsa000300.90277672
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.89981187
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89835297
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88669451
67Lysosome_Homo sapiens_hsa041420.87034384
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85579565
69Tyrosine metabolism_Homo sapiens_hsa003500.83786752
70Prion diseases_Homo sapiens_hsa050200.83427505
71Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.81819676
72DNA replication_Homo sapiens_hsa030300.81111213
73Sphingolipid metabolism_Homo sapiens_hsa006000.78024467
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76632197
75Glutathione metabolism_Homo sapiens_hsa004800.76455287
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76231556
77Ether lipid metabolism_Homo sapiens_hsa005650.75075288
78Notch signaling pathway_Homo sapiens_hsa043300.73968665
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72831682
80Phenylalanine metabolism_Homo sapiens_hsa003600.70385294
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70041070
82Mineral absorption_Homo sapiens_hsa049780.70026105
83Other glycan degradation_Homo sapiens_hsa005110.69509505
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.69001942
85Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67418943
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60551120
87Selenocompound metabolism_Homo sapiens_hsa004500.58452123
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.53868840
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53427935
90Insulin signaling pathway_Homo sapiens_hsa049100.53164676
91Fatty acid biosynthesis_Homo sapiens_hsa000610.51613647
92Pyrimidine metabolism_Homo sapiens_hsa002400.51335515
93Metabolic pathways_Homo sapiens_hsa011000.48628472
94Malaria_Homo sapiens_hsa051440.43179508
95Fructose and mannose metabolism_Homo sapiens_hsa000510.42529287
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.41815138
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39828521
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39808096
99Renin-angiotensin system_Homo sapiens_hsa046140.39666395
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.36719548
101Linoleic acid metabolism_Homo sapiens_hsa005910.36714150
102Glucagon signaling pathway_Homo sapiens_hsa049220.36560194
103T cell receptor signaling pathway_Homo sapiens_hsa046600.35437793
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33554573
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33096079
106Galactose metabolism_Homo sapiens_hsa000520.31272125
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.29921755
108Intestinal immune network for IgA production_Homo sapiens_hsa046720.29834086
109Glycosaminoglycan degradation_Homo sapiens_hsa005310.29294134
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28270121
111Chronic myeloid leukemia_Homo sapiens_hsa052200.27408808
112Lysine degradation_Homo sapiens_hsa003100.26839021
113Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.25927714
114Synaptic vesicle cycle_Homo sapiens_hsa047210.24611830
115Thyroid hormone synthesis_Homo sapiens_hsa049180.24606225
116Hematopoietic cell lineage_Homo sapiens_hsa046400.24578038
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24069443
118Oxidative phosphorylation_Homo sapiens_hsa001900.23916856
119Protein digestion and absorption_Homo sapiens_hsa049740.23339948
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.22757757
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.21947214
122ECM-receptor interaction_Homo sapiens_hsa045120.21460210
123Hepatitis C_Homo sapiens_hsa051600.20277356
124Parkinsons disease_Homo sapiens_hsa050120.19643824
125Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.18999859
126Pertussis_Homo sapiens_hsa051330.18849427
127Acute myeloid leukemia_Homo sapiens_hsa052210.17222458
128Insulin resistance_Homo sapiens_hsa049310.17087602
129B cell receptor signaling pathway_Homo sapiens_hsa046620.16723789
130Endometrial cancer_Homo sapiens_hsa052130.15969466
131Maturity onset diabetes of the young_Homo sapiens_hsa049500.14721643
132VEGF signaling pathway_Homo sapiens_hsa043700.14069365
133Alzheimers disease_Homo sapiens_hsa050100.13700337

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