ILKAP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.85835600
2viral transcription (GO:0019083)5.04637791
3male meiosis I (GO:0007141)5.04116455
4DNA deamination (GO:0045006)4.97186506
5translational termination (GO:0006415)4.89517871
6DNA unwinding involved in DNA replication (GO:0006268)4.77876548
7piRNA metabolic process (GO:0034587)4.67583157
8translational elongation (GO:0006414)4.52744055
9deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.50229237
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.39878738
11DNA strand elongation involved in DNA replication (GO:0006271)4.33623753
12telomere maintenance via semi-conservative replication (GO:0032201)4.32311071
13meiosis I (GO:0007127)4.30410203
14maturation of SSU-rRNA (GO:0030490)4.29057171
15protein targeting to ER (GO:0045047)4.24222101
16cotranslational protein targeting to membrane (GO:0006613)4.22862708
17negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.14916397
18negative regulation of RNA splicing (GO:0033119)4.13282098
19DNA strand elongation (GO:0022616)4.10299250
20folic acid-containing compound biosynthetic process (GO:0009396)4.06107685
21establishment of protein localization to endoplasmic reticulum (GO:0072599)4.05577507
22nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.04055089
23protein localization to endoplasmic reticulum (GO:0070972)3.96985914
24pyrimidine nucleotide catabolic process (GO:0006244)3.96213215
25synapsis (GO:0007129)3.94970208
26translational initiation (GO:0006413)3.93189157
27viral life cycle (GO:0019058)3.92464544
28metallo-sulfur cluster assembly (GO:0031163)3.75969951
29iron-sulfur cluster assembly (GO:0016226)3.75969951
30telomere maintenance via recombination (GO:0000722)3.72609160
31DNA methylation involved in gamete generation (GO:0043046)3.72280351
32formation of translation preinitiation complex (GO:0001731)3.70504084
33ribosomal small subunit biogenesis (GO:0042274)3.68496991
34cellular protein complex disassembly (GO:0043624)3.68068731
35base-excision repair, AP site formation (GO:0006285)3.65409431
36DNA replication initiation (GO:0006270)3.56797621
37DNA synthesis involved in DNA repair (GO:0000731)3.49906866
38mitotic recombination (GO:0006312)3.49846400
39protein complex disassembly (GO:0043241)3.45901568
40meiotic nuclear division (GO:0007126)3.39544830
41chromosome organization involved in meiosis (GO:0070192)3.37341831
42negative regulation of mRNA processing (GO:0050686)3.34440793
43positive regulation of B cell differentiation (GO:0045579)3.33179139
44male meiosis (GO:0007140)3.31673615
45positive regulation of gamma-delta T cell activation (GO:0046645)3.27621033
46meiotic chromosome segregation (GO:0045132)3.26928422
47macromolecular complex disassembly (GO:0032984)3.26338044
48telomere maintenance via telomere lengthening (GO:0010833)3.25881360
49nuclear-transcribed mRNA catabolic process (GO:0000956)3.23678212
50DNA replication-dependent nucleosome organization (GO:0034723)3.19874218
51DNA replication-dependent nucleosome assembly (GO:0006335)3.19874218
52translesion synthesis (GO:0019985)3.19315214
53nucleotide-excision repair, DNA gap filling (GO:0006297)3.13168776
54translation (GO:0006412)3.11684502
55ribosomal large subunit biogenesis (GO:0042273)3.11570372
56regulation of mitochondrial translation (GO:0070129)3.11255505
57pteridine-containing compound biosynthetic process (GO:0042559)3.11104213
58pseudouridine synthesis (GO:0001522)3.09167899
59ribonucleoprotein complex biogenesis (GO:0022613)3.06904112
60DNA replication checkpoint (GO:0000076)3.06791911
61mRNA catabolic process (GO:0006402)3.05775501
62negative regulation of mRNA metabolic process (GO:1903312)3.03966906
63reciprocal DNA recombination (GO:0035825)3.02627821
64reciprocal meiotic recombination (GO:0007131)3.02627821
65RNA catabolic process (GO:0006401)2.98879137
66viral mRNA export from host cell nucleus (GO:0046784)2.97992434
67pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.96959765
68IMP biosynthetic process (GO:0006188)2.95575113
69sister chromatid cohesion (GO:0007062)2.95295041
70pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.92561597
71spliceosomal complex assembly (GO:0000245)2.92347080
72RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.91687365
73mRNA splicing, via spliceosome (GO:0000398)2.91687365
74deoxyribonucleotide catabolic process (GO:0009264)2.91217972
75RNA splicing, via transesterification reactions (GO:0000375)2.89814466
76cellular response to interferon-beta (GO:0035458)2.89810942
77termination of RNA polymerase II transcription (GO:0006369)2.87400333
78histone H2A acetylation (GO:0043968)2.86904085
79spliceosomal snRNP assembly (GO:0000387)2.85584134
80ribosome biogenesis (GO:0042254)2.85234630
81regulation of protein heterodimerization activity (GO:0043497)2.85219912
82synaptonemal complex assembly (GO:0007130)2.84083755
83proteasome assembly (GO:0043248)2.83245104
84protein targeting to membrane (GO:0006612)2.80625775
85pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.80257030
86IMP metabolic process (GO:0046040)2.79270801
87protein autoprocessing (GO:0016540)2.79094074
88tRNA modification (GO:0006400)2.77895927
89L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.77366813
90base-excision repair (GO:0006284)2.74623337
91regulation of gamma-delta T cell differentiation (GO:0045586)2.73584741
92DNA duplex unwinding (GO:0032508)2.72643521
93mannosylation (GO:0097502)2.72198528
94positive regulation of prostaglandin secretion (GO:0032308)2.71280130
95deoxyribose phosphate catabolic process (GO:0046386)2.70746158
96antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.70151764
97antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.70151764
98alternative mRNA splicing, via spliceosome (GO:0000380)2.69978960
99DNA geometric change (GO:0032392)2.69838123
100antigen processing and presentation via MHC class Ib (GO:0002475)2.69693719
101pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.68790354
102mitotic nuclear envelope disassembly (GO:0007077)2.68550379
103nucleobase biosynthetic process (GO:0046112)2.68093463
104postreplication repair (GO:0006301)2.67557727
105synaptonemal complex organization (GO:0070193)2.66955236
106DNA catabolic process, exonucleolytic (GO:0000738)2.65653196
107mitochondrial DNA replication (GO:0006264)2.65485197
108preassembly of GPI anchor in ER membrane (GO:0016254)2.65013875
109tRNA methylation (GO:0030488)2.63144252
110telomere organization (GO:0032200)2.60753523
111telomere maintenance (GO:0000723)2.60722627
112rRNA processing (GO:0006364)2.60239949
113dosage compensation (GO:0007549)2.56707302
114regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.56186180
115DNA replication-independent nucleosome organization (GO:0034724)2.55988361
116DNA replication-independent nucleosome assembly (GO:0006336)2.55988361
117mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.55704842
118mitochondrial respiratory chain complex I assembly (GO:0032981)2.55704842
119NADH dehydrogenase complex assembly (GO:0010257)2.55704842
120regulation of chromatin binding (GO:0035561)2.55308422
1213-UTR-mediated mRNA stabilization (GO:0070935)2.54576999
122T cell apoptotic process (GO:0070231)2.53578474
123pyrimidine dimer repair (GO:0006290)2.52624046
124protein K6-linked ubiquitination (GO:0085020)2.51356117
125regulation of translational fidelity (GO:0006450)2.49326746
126regulation of gamma-delta T cell activation (GO:0046643)2.48990432
127rRNA metabolic process (GO:0016072)2.48879331
128negative regulation of interleukin-12 production (GO:0032695)2.48529590
129tRNA aminoacylation for protein translation (GO:0006418)2.48357336
130exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.48189299
131ncRNA 3-end processing (GO:0043628)2.48014559
132lipopolysaccharide biosynthetic process (GO:0009103)2.47422151
133nucleoside salvage (GO:0043174)2.47199124
134antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.47124077
135DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.46785550
136positive regulation of mitochondrial fission (GO:0090141)2.46471561
137nuclear envelope disassembly (GO:0051081)2.46450592
138membrane disassembly (GO:0030397)2.46450592
139purine-containing compound salvage (GO:0043101)2.45910426
140amino acid activation (GO:0043038)2.45069994
141regulation of double-strand break repair via homologous recombination (GO:0010569)2.44829310
142microtubule nucleation (GO:0007020)2.43662085
143positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.43648867
144purine deoxyribonucleotide catabolic process (GO:0009155)2.40730118
145signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.38557142
146signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.38557142
147signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.38557142
148signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.37540578
149intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.37540578
150meiotic cell cycle process (GO:1903046)2.37081260
151DNA double-strand break processing (GO:0000729)2.36316490
152DNA modification (GO:0006304)2.33782085
1532-deoxyribonucleotide metabolic process (GO:0009394)2.33084204
154positive regulation of T cell cytokine production (GO:0002726)2.32457977
155positive regulation of granulocyte differentiation (GO:0030854)2.32320671
156positive T cell selection (GO:0043368)2.32050904
157signal transduction involved in DNA integrity checkpoint (GO:0072401)2.31080864
158signal transduction involved in DNA damage checkpoint (GO:0072422)2.31080864
159nucleotide salvage (GO:0043173)2.30416261
160signal transduction involved in cell cycle checkpoint (GO:0072395)2.29913287
161tRNA processing (GO:0008033)2.29052078
162ubiquinone biosynthetic process (GO:0006744)2.28644435
163protein complex biogenesis (GO:0070271)2.27385964
164regulation of histone H3-K9 methylation (GO:0051570)2.27149047
165chromatin remodeling at centromere (GO:0031055)2.27060085
166CENP-A containing nucleosome assembly (GO:0034080)2.26181774
167NIK/NF-kappaB signaling (GO:0038061)2.25825209
168positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.25652013
169cytochrome complex assembly (GO:0017004)2.25584914
170mismatch repair (GO:0006298)2.25099649
171negative regulation of B cell apoptotic process (GO:0002903)2.23832962
172positive regulation of response to oxidative stress (GO:1902884)2.23473891
173positive regulation of cellular response to oxidative stress (GO:1900409)2.23473891
174protein K11-linked deubiquitination (GO:0035871)2.23097843
175negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.21426648
176RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.20923540
177mitochondrial respiratory chain complex assembly (GO:0033108)2.20268812
178methionine metabolic process (GO:0006555)2.19599548
179regulation of B cell differentiation (GO:0045577)2.18962308
180RNA modification (GO:0009451)2.18806858
181deoxyribose phosphate metabolic process (GO:0019692)2.16314121
182peptidyl-histidine modification (GO:0018202)2.16309482
183regulation of immunoglobulin secretion (GO:0051023)2.16118378
184GPI anchor metabolic process (GO:0006505)2.16108295

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.52979063
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.00811794
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.79527822
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.11818432
5MYC_22102868_ChIP-Seq_BL_Human2.58477292
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.55458860
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.53638906
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.50641104
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.46303267
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.44790425
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.40042702
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.37038934
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.35061075
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.31939298
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.31289965
16TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.27311374
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.26654277
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.21302228
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.20396409
20XRN2_22483619_ChIP-Seq_HELA_Human2.19068369
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.18963925
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.18142409
23CIITA_25753668_ChIP-Seq_RAJI_Human2.14131985
24VDR_23849224_ChIP-Seq_CD4+_Human2.12994415
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.12985662
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.09286155
27VDR_21846776_ChIP-Seq_THP-1_Human1.98740263
28NELFA_20434984_ChIP-Seq_ESCs_Mouse1.98299318
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.97936581
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.96910754
31CREB1_15753290_ChIP-ChIP_HEK293T_Human1.94911102
32DCP1A_22483619_ChIP-Seq_HELA_Human1.84366083
33FOXP3_21729870_ChIP-Seq_TREG_Human1.83459902
34GABP_19822575_ChIP-Seq_HepG2_Human1.80044423
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.78060998
36SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.77157493
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.75580951
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.74788201
39* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.72334179
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.71540102
41ZNF274_21170338_ChIP-Seq_K562_Hela1.69481328
42ERG_20887958_ChIP-Seq_HPC-7_Mouse1.69344035
43STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.69249211
44CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.65790250
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.64655079
46IRF8_22096565_ChIP-ChIP_GC-B_Human1.63491259
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.62471099
48* E2F1_21310950_ChIP-Seq_MCF-7_Human1.61506345
49STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.57499660
50* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.57451088
51TTF2_22483619_ChIP-Seq_HELA_Human1.57066273
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56895721
53CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.53672525
54IRF8_21731497_ChIP-ChIP_J774_Mouse1.51545987
55MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.49595741
56TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48994117
57* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48284289
58IGF1R_20145208_ChIP-Seq_DFB_Human1.46015259
59IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.44892728
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.43679628
61BCL6_27268052_Chip-Seq_Bcells_Human1.43262134
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.42967938
63MYCN_18555785_ChIP-Seq_MESCs_Mouse1.42463263
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37173083
65GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.36890952
66RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.36102293
67SRF_21415370_ChIP-Seq_HL-1_Mouse1.35493087
68KDM5A_27292631_Chip-Seq_BREAST_Human1.33228761
69TFEB_21752829_ChIP-Seq_HELA_Human1.32807887
70MAF_26560356_Chip-Seq_TH1_Human1.32654055
71* SPI1_23547873_ChIP-Seq_NB4_Human1.32272337
72FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.32245236
73YY1_21170310_ChIP-Seq_MESCs_Mouse1.32017347
74BP1_19119308_ChIP-ChIP_Hs578T_Human1.31768338
75IRF1_19129219_ChIP-ChIP_H3396_Human1.31758726
76CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.30993705
77SCL_19346495_ChIP-Seq_HPC-7_Human1.30668409
78MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.29579382
79UTX_26944678_Chip-Seq_JUKART_Human1.27916175
80YY1_22570637_ChIP-Seq_MALME-3M_Human1.26558567
81POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.26442601
82* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26049016
83NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24961777
84ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24415413
85TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24275151
86ELK1_19687146_ChIP-ChIP_HELA_Human1.23457018
87ELF1_20517297_ChIP-Seq_JURKAT_Human1.22510403
88LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22338575
89HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22117197
90YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20229316
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18791079
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.17949327
93NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.17921109
94GATA3_26560356_Chip-Seq_TH2_Human1.17575752
95FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16980428
96MYC_18940864_ChIP-ChIP_HL60_Human1.16061464
97GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15562254
98BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.15051458
99KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14922292
100CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.14736349
101AR_21909140_ChIP-Seq_LNCAP_Human1.13863449
102TCF7_22412390_ChIP-Seq_EML_Mouse1.13475814
103ZNF263_19887448_ChIP-Seq_K562_Human1.12504320
104E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12335841
105* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11221141
106SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.10869026
107EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.10418209
108MYB_26560356_Chip-Seq_TH1_Human1.09357337
109PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08009533
110BCOR_27268052_Chip-Seq_Bcells_Human1.07896998
111CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06616722
112STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05712514
113GATA3_27048872_Chip-Seq_THYMUS_Human1.05267603
114TP63_19390658_ChIP-ChIP_HaCaT_Human1.05254867
115MYB_26560356_Chip-Seq_TH2_Human1.04980423
116RUNX1_22412390_ChIP-Seq_EML_Mouse1.04119352
117MAF_26560356_Chip-Seq_TH2_Human1.02522304
118VDR_24763502_ChIP-Seq_THP-1_Human1.01424816
119PHF8_20622854_ChIP-Seq_HELA_Human1.01359520
120MYB_21317192_ChIP-Seq_ERMYB_Mouse0.99672920
121CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98751156
122* ELK3_25401928_ChIP-Seq_HUVEC_Human0.96765086
123CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96619716
124GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96297046
125STAT4_19710469_ChIP-ChIP_TH1__Mouse0.96007605
126PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.95567161
127CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94467545
128TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93730426
129* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.93596289

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.38656240
2MP0003646_muscle_fatigue2.97250945
3MP0010094_abnormal_chromosome_stability2.92155409
4MP0000372_irregular_coat_pigmentation2.88857632
5MP0008877_abnormal_DNA_methylation2.85047668
6MP0004957_abnormal_blastocyst_morpholog2.82606346
7MP0002396_abnormal_hematopoietic_system2.69970304
8MP0003111_abnormal_nucleus_morphology2.58949180
9MP0003077_abnormal_cell_cycle2.56829654
10MP0003763_abnormal_thymus_physiology2.25785542
11MP0002822_catalepsy2.24857183
12MP0000015_abnormal_ear_pigmentation2.23755196
13MP0008007_abnormal_cellular_replicative2.20165028
14MP0004808_abnormal_hematopoietic_stem2.18947658
15MP0001835_abnormal_antigen_presentation2.11691754
16MP0000685_abnormal_immune_system2.11254849
17MP0008995_early_reproductive_senescence2.11131837
18MP0002166_altered_tumor_susceptibility2.09551005
19MP0008058_abnormal_DNA_repair2.05046996
20MP0000490_abnormal_crypts_of2.02388334
21MP0010352_gastrointestinal_tract_polyps2.01110354
22MP0002398_abnormal_bone_marrow1.87733233
23MP0002102_abnormal_ear_morphology1.84640272
24MP0002148_abnormal_hypersensitivity_rea1.80644059
25MP0000703_abnormal_thymus_morphology1.75196307
26MP0001730_embryonic_growth_arrest1.71499564
27MP0006054_spinal_hemorrhage1.71378003
28MP0001545_abnormal_hematopoietic_system1.68852451
29MP0005397_hematopoietic_system_phenotyp1.68852451
30MP0008057_abnormal_DNA_replication1.67856750
31MP0002722_abnormal_immune_system1.66858517
32MP0005645_abnormal_hypothalamus_physiol1.61059164
33MP0000350_abnormal_cell_proliferation1.58195181
34MP0002210_abnormal_sex_determination1.57021708
35MP0005076_abnormal_cell_differentiation1.55907474
36MP0005671_abnormal_response_to1.53790070
37MP0009333_abnormal_splenocyte_physiolog1.53152834
38MP0004147_increased_porphyrin_level1.51114687
39MP0000689_abnormal_spleen_morphology1.50570831
40MP0002006_tumorigenesis1.49197309
41MP0001873_stomach_inflammation1.47847775
42MP0002019_abnormal_tumor_incidence1.47533765
43MP0009785_altered_susceptibility_to1.47480888
44MP0001929_abnormal_gametogenesis1.46499544
45MP0001800_abnormal_humoral_immune1.46224754
46MP0002429_abnormal_blood_cell1.44343539
47MP0009764_decreased_sensitivity_to1.42831277
48MP0000716_abnormal_immune_system1.38449046
49MP0005174_abnormal_tail_pigmentation1.32696170
50MP0001853_heart_inflammation1.32159143
51MP0004142_abnormal_muscle_tone1.31688343
52MP0005389_reproductive_system_phenotype1.31116099
53MP0001849_ear_inflammation1.31094553
54MP0002420_abnormal_adaptive_immunity1.30917870
55MP0003172_abnormal_lysosome_physiology1.30083531
56MP0001819_abnormal_immune_cell1.29621479
57MP0002452_abnormal_antigen_presenting1.29467210
58MP0002080_prenatal_lethality1.28657568
59MP0008932_abnormal_embryonic_tissue1.28180539
60MP0000313_abnormal_cell_death1.26921295
61MP0004197_abnormal_fetal_growth/weight/1.24258767
62MP0006036_abnormal_mitochondrial_physio1.21493730
63MP0003567_abnormal_fetal_cardiomyocyte1.21005091
64MP0003698_abnormal_male_reproductive1.20240781
65MP0001919_abnormal_reproductive_system1.20014140
66MP0002723_abnormal_immune_serum1.19985865
67MP0002160_abnormal_reproductive_system1.18824522
68MP0003786_premature_aging1.18726496
69MP0010155_abnormal_intestine_physiology1.18605028
70MP0001145_abnormal_male_reproductive1.18279597
71MP0003705_abnormal_hypodermis_morpholog1.18215017
72MP0002277_abnormal_respiratory_mucosa1.15649334
73MP0001697_abnormal_embryo_size1.13963672
74MP0003656_abnormal_erythrocyte_physiolo1.13237579
75MP0003866_abnormal_defecation1.12353578
76MP0003984_embryonic_growth_retardation1.12199391
77MP0005266_abnormal_metabolism1.12172967
78MP0003136_yellow_coat_color1.12076164
79MP0000653_abnormal_sex_gland1.09975557
80MP0005025_abnormal_response_to1.08497152
81MP0005310_abnormal_salivary_gland1.07551617
82MP0002088_abnormal_embryonic_growth/wei1.07397931
83MP0010307_abnormal_tumor_latency1.07397347
84MP0008961_abnormal_basal_metabolism1.07161343
85MP0000358_abnormal_cell_content/1.06142928
86MP0005464_abnormal_platelet_physiology1.06109495
87MP0002837_dystrophic_cardiac_calcinosis1.05714910
88MP0000858_altered_metastatic_potential1.05711569
89MP0001672_abnormal_embryogenesis/_devel1.05640513
90MP0005380_embryogenesis_phenotype1.05640513
91MP0002163_abnormal_gland_morphology1.04370462
92MP0005058_abnormal_lysosome_morphology1.00132713
93MP0002419_abnormal_innate_immunity0.99688922
94MP0004510_myositis0.99575535
95MP0001293_anophthalmia0.99169018
96MP0000733_abnormal_muscle_development0.99078059
97MP0005000_abnormal_immune_tolerance0.98053169
98MP0004947_skin_inflammation0.98043902
99MP0003300_gastrointestinal_ulcer0.97731495
100MP0005387_immune_system_phenotype0.97442961
101MP0001790_abnormal_immune_system0.97442961
102MP0003436_decreased_susceptibility_to0.96058556
103MP0002086_abnormal_extraembryonic_tissu0.95501695
104MP0002132_abnormal_respiratory_system0.94791605
105MP0003806_abnormal_nucleotide_metabolis0.93691422
106MP0002653_abnormal_ependyma_morphology0.92613643
107MP0002405_respiratory_system_inflammati0.92583727
108MP0009840_abnormal_foam_cell0.92300766
109MP0001188_hyperpigmentation0.91774641
110MP0000537_abnormal_urethra_morphology0.90531991
111MP0005253_abnormal_eye_physiology0.90277676
112MP0005075_abnormal_melanosome_morpholog0.89803152
113MP0000371_diluted_coat_color0.89344724
114MP0005220_abnormal_exocrine_pancreas0.88798064
115MP0000598_abnormal_liver_morphology0.88648581
116MP0009379_abnormal_foot_pigmentation0.88297616
117MP0000465_gastrointestinal_hemorrhage0.87761614
118MP0000678_abnormal_parathyroid_gland0.87534282
119MP0000477_abnormal_intestine_morphology0.87023232
120MP0003123_paternal_imprinting0.86476533
121MP0002084_abnormal_developmental_patter0.86459814
122MP0003943_abnormal_hepatobiliary_system0.85721858
123MP0001119_abnormal_female_reproductive0.85099369
124MP0002085_abnormal_embryonic_tissue0.84865013
125MP0002138_abnormal_hepatobiliary_system0.84218683
126MP0000569_abnormal_digit_pigmentation0.82024125
127MP0006082_CNS_inflammation0.81729852
128MP0006072_abnormal_retinal_apoptosis0.81193408
129MP0005647_abnormal_sex_gland0.80747535
130MP0002075_abnormal_coat/hair_pigmentati0.80739904
131MP0009278_abnormal_bone_marrow0.80719631
132MP0001845_abnormal_inflammatory_respons0.80209917
133MP0003186_abnormal_redox_activity0.79191396
134MP0000383_abnormal_hair_follicle0.78092326
135MP0009046_muscle_twitch0.77606949
136MP0005551_abnormal_eye_electrophysiolog0.77527446
137MP0009053_abnormal_anal_canal0.76623219
138MP0002095_abnormal_skin_pigmentation0.76387308
139MP0000750_abnormal_muscle_regeneration0.76292154
140MP0006035_abnormal_mitochondrial_morpho0.73673372
141MP0008260_abnormal_autophagy0.73530843
142MP0001501_abnormal_sleep_pattern0.73466856
143MP0002234_abnormal_pharynx_morphology0.72941453
144MP0001764_abnormal_homeostasis0.71639712
145MP0005167_abnormal_blood-brain_barrier0.71341035
146MP0001986_abnormal_taste_sensitivity0.71022942
147MP0006292_abnormal_olfactory_placode0.70355826
148MP0010030_abnormal_orbit_morphology0.70016079

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.15003399
2Abnormal number of erythroid precursors (HP:0012131)4.90603995
3Reticulocytopenia (HP:0001896)3.98436048
4Abnormality of the heme biosynthetic pathway (HP:0010472)3.65127552
5Thrombocytosis (HP:0001894)3.54457104
6Pallor (HP:0000980)3.51055474
7Hepatocellular necrosis (HP:0001404)3.26421510
8Progressive microcephaly (HP:0000253)3.22865628
9Stomatitis (HP:0010280)3.03192941
10Aplastic anemia (HP:0001915)3.02927811
11Hepatic necrosis (HP:0002605)2.92461940
12Mitochondrial inheritance (HP:0001427)2.85088752
13Increased CSF lactate (HP:0002490)2.71417680
14Basal cell carcinoma (HP:0002671)2.68819545
15Macrocytic anemia (HP:0001972)2.68793431
16Panhypogammaglobulinemia (HP:0003139)2.67561805
17Selective tooth agenesis (HP:0001592)2.67146828
18Decreased activity of mitochondrial respiratory chain (HP:0008972)2.64721919
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.64721919
20Colon cancer (HP:0003003)2.63406416
21Elevated erythrocyte sedimentation rate (HP:0003565)2.58967413
22Muscle fiber atrophy (HP:0100295)2.57726703
23Amaurosis fugax (HP:0100576)2.55347722
24IgM deficiency (HP:0002850)2.49832725
25Microretrognathia (HP:0000308)2.48146212
26IgG deficiency (HP:0004315)2.47845512
27Pancreatic cysts (HP:0001737)2.46713832
28Acute necrotizing encephalopathy (HP:0006965)2.45537118
29Chronic otitis media (HP:0000389)2.45066283
30B lymphocytopenia (HP:0010976)2.42963220
31Abnormality of B cell number (HP:0010975)2.42963220
32Tubulointerstitial nephritis (HP:0001970)2.39366473
33Progressive muscle weakness (HP:0003323)2.36722384
34Optic nerve coloboma (HP:0000588)2.36122640
35Microvesicular hepatic steatosis (HP:0001414)2.35448836
36Multiple enchondromatosis (HP:0005701)2.35004202
37Pustule (HP:0200039)2.34629664
38Recurrent viral infections (HP:0004429)2.33498880
39Abnormality of the renal cortex (HP:0011035)2.33458191
40Abnormal mitochondria in muscle tissue (HP:0008316)2.32009983
41Type 2 muscle fiber atrophy (HP:0003554)2.31424168
42Abnormality of midbrain morphology (HP:0002418)2.30315173
43Molar tooth sign on MRI (HP:0002419)2.30315173
44Ragged-red muscle fibers (HP:0003200)2.28379792
45Type I transferrin isoform profile (HP:0003642)2.27861256
46Albinism (HP:0001022)2.27803881
47Petechiae (HP:0000967)2.27021289
48Birth length less than 3rd percentile (HP:0003561)2.25283092
49Increased intramyocellular lipid droplets (HP:0012240)2.25128652
50Oral leukoplakia (HP:0002745)2.22147869
5111 pairs of ribs (HP:0000878)2.21070869
52Abnormality of T cell physiology (HP:0011840)2.20613377
53Type II lissencephaly (HP:0007260)2.19383802
54Opisthotonus (HP:0002179)2.16489383
55Abnormality of T cells (HP:0002843)2.16207965
56Increased neuronal autofluorescent lipopigment (HP:0002074)2.14549207
57Poor head control (HP:0002421)2.14196144
58Trismus (HP:0000211)2.12070166
59Increased muscle lipid content (HP:0009058)2.12045151
60Hyperacusis (HP:0010780)2.11864423
61Prominent nose (HP:0000448)2.11564332
62Pancreatic fibrosis (HP:0100732)2.11459020
63Lactic acidosis (HP:0003128)2.10821803
64Ependymoma (HP:0002888)2.09189797
65Progressive inability to walk (HP:0002505)2.06748033
66Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.06302587
67Nephronophthisis (HP:0000090)2.05745246
68High pitched voice (HP:0001620)2.05470758
69Recurrent bronchitis (HP:0002837)2.05091448
70Prolonged bleeding time (HP:0003010)2.05007511
71Absent rod-and cone-mediated responses on ERG (HP:0007688)2.04860477
72Abnormality of cells of the lymphoid lineage (HP:0012140)2.04576912
73Acute encephalopathy (HP:0006846)2.02564989
74Abnormal protein glycosylation (HP:0012346)2.01911671
75Abnormal glycosylation (HP:0012345)2.01911671
76Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.01911671
77Abnormal protein N-linked glycosylation (HP:0012347)2.01911671
78Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.01752517
79Abnormality of liposaccharide metabolism (HP:0010968)2.01665139
80Abnormality of glycosphingolipid metabolism (HP:0004343)2.01665139
81Abnormality of glycolipid metabolism (HP:0010969)2.01665139
82Chronic hepatic failure (HP:0100626)2.00860096
83Abnormality of the anterior horn cell (HP:0006802)2.00548734
84Degeneration of anterior horn cells (HP:0002398)2.00548734
85Absent thumb (HP:0009777)2.00428430
86Broad distal phalanx of finger (HP:0009836)1.98924636
87Abnormal delayed hypersensitivity skin test (HP:0002963)1.98702960
88Decreased electroretinogram (ERG) amplitude (HP:0000654)1.97374935
89Medulloblastoma (HP:0002885)1.95781335
90Lymphopenia (HP:0001888)1.95269448
91Lymphoma (HP:0002665)1.94597559
92Hypoplasia of the pons (HP:0012110)1.94328081
93True hermaphroditism (HP:0010459)1.93981682
94Abnormality of the prostate (HP:0008775)1.93307971
95Amyotrophic lateral sclerosis (HP:0007354)1.93160294
96Encephalitis (HP:0002383)1.92489727
97Gastrointestinal inflammation (HP:0004386)1.92386088
98Mediastinal lymphadenopathy (HP:0100721)1.92278636
99Increased serum ferritin (HP:0003281)1.92095615
100Abnormality of dicarboxylic acid metabolism (HP:0010995)1.91835095
101Dicarboxylic aciduria (HP:0003215)1.91835095
102Volvulus (HP:0002580)1.91663517
103Abnormality of the fingertips (HP:0001211)1.91477003
104Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.90037405
105Abnormality of alanine metabolism (HP:0010916)1.90037405
106Hyperalaninemia (HP:0003348)1.90037405
107Abnormality of the renal medulla (HP:0100957)1.88927464
108Cerebral palsy (HP:0100021)1.88873896
109Recurrent bacterial skin infections (HP:0005406)1.88718961
110Progressive macrocephaly (HP:0004481)1.88428915
111Myelodysplasia (HP:0002863)1.87893413
112Increased cerebral lipofuscin (HP:0011813)1.87357972
113Cellular immunodeficiency (HP:0005374)1.87326005
114Abnormality of reticulocytes (HP:0004312)1.85726337
115Increased IgM level (HP:0003496)1.85708231
116Proximal placement of thumb (HP:0009623)1.85369372
117Lissencephaly (HP:0001339)1.84920389
118IgA deficiency (HP:0002720)1.84415518
119Acute hepatic failure (HP:0006554)1.83270164
120Recurrent fungal infections (HP:0002841)1.82121019
121Methylmalonic aciduria (HP:0012120)1.81574462
122Ocular albinism (HP:0001107)1.81016091
123Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.80737327
124Abnormal number of incisors (HP:0011064)1.80736398
125Autoimmune thrombocytopenia (HP:0001973)1.80670251
126Abnormal drinking behavior (HP:0030082)1.80423526
127Polydipsia (HP:0001959)1.80423526
128Microcytic anemia (HP:0001935)1.80111354
129Abnormality of the pancreatic islet cells (HP:0006476)1.78915337
130Abnormality of endocrine pancreas physiology (HP:0012093)1.78915337
131Epistaxis (HP:0000421)1.78061613
132Cleft eyelid (HP:0000625)1.77473074
133Atrophy/Degeneration involving motor neurons (HP:0007373)1.77179343
134Abnormality of fatty-acid metabolism (HP:0004359)1.75505877
135Abnormal biliary tract physiology (HP:0012439)1.74505121
136Bile duct proliferation (HP:0001408)1.74505121
137Prostate neoplasm (HP:0100787)1.74328752
138Severe global developmental delay (HP:0011344)1.74252373
139Cerebral hypomyelination (HP:0006808)1.74096587
140Optic disc pallor (HP:0000543)1.73509854
141Inability to walk (HP:0002540)1.73216448
142Absent speech (HP:0001344)1.72258938
143Shoulder girdle muscle weakness (HP:0003547)1.71926581
144Lipid accumulation in hepatocytes (HP:0006561)1.71733991
145Acute lymphatic leukemia (HP:0006721)1.71600327
146Adenoma sebaceum (HP:0009720)1.71329106
147Angiofibromas (HP:0010615)1.71329106
148Increased nuchal translucency (HP:0010880)1.71252188
149Renal cortical cysts (HP:0000803)1.69417090
150Chronic mucocutaneous candidiasis (HP:0002728)1.69293279
151Recurrent cutaneous fungal infections (HP:0011370)1.69293279
152Poor eye contact (HP:0000817)1.67602581
153Reduced antithrombin III activity (HP:0001976)1.67289847
154Agammaglobulinemia (HP:0004432)1.67218800
155CNS demyelination (HP:0007305)1.66976597
156Colitis (HP:0002583)1.66947154
157Combined immunodeficiency (HP:0005387)1.66127017
158Abnormality of DNA repair (HP:0003254)1.65686301
159Severe combined immunodeficiency (HP:0004430)1.65338940
160Prolonged neonatal jaundice (HP:0006579)1.65303471
161Retinal dysplasia (HP:0007973)1.65253296
162Neoplasm of the pancreas (HP:0002894)1.65079580
163Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.64982612
164Large eyes (HP:0001090)1.63630514
165Skin tags (HP:0010609)1.61303594
166Patellar aplasia (HP:0006443)1.60985471
167Hypoplasia of the thymus (HP:0000778)1.60796280
168Impaired platelet aggregation (HP:0003540)1.60547478
169Abnormal platelet function (HP:0011869)1.60547478
170Prominent metopic ridge (HP:0005487)1.60498454
171Deviation of the thumb (HP:0009603)1.60419777
172Carpal bone hypoplasia (HP:0001498)1.59679183
173Abnormality of iron homeostasis (HP:0011031)1.58647446
174Inflammation of the large intestine (HP:0002037)1.58324965
175Vertebral compression fractures (HP:0002953)1.57982230
176Increased serum lactate (HP:0002151)1.56020721
177Premature graying of hair (HP:0002216)1.55367233
178Limb-girdle muscle atrophy (HP:0003797)1.54145851
1793-Methylglutaconic aciduria (HP:0003535)1.54136622
180Pancytopenia (HP:0001876)1.53539017

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.02518145
2TAOK12.83960149
3VRK22.69697910
4FLT32.68151415
5MAP3K102.65352661
6MAP4K22.64830005
7MAP4K12.61511071
8WEE12.51818619
9ZAK2.48830705
10NUAK12.40939328
11CDC72.39705523
12TRIB32.35712185
13SCYL22.31400100
14PKN22.28076580
15EEF2K2.27406386
16TAOK32.26935654
17TGFBR12.22585348
18FGFR41.99125124
19PASK1.91699329
20CCNB11.90772832
21PNCK1.89053135
22NEK21.82716643
23ACVR1B1.82407439
24BCKDK1.82255049
25ERN11.77745734
26EIF2AK31.66149233
27BUB11.63314307
28LRRK21.61789228
29RPS6KB21.58687428
30MAP2K31.58002541
31JAK31.53501077
32TLK11.49821020
33KDR1.47613012
34ADRBK21.45830023
35BTK1.45495550
36DYRK31.44299638
37RPS6KA41.41755983
38ZAP701.40301061
39TBK11.39865157
40VRK11.38316781
41ATR1.36272654
42KIT1.33266656
43TYK21.32459952
44EIF2AK11.31359245
45MAP2K71.24131347
46PLK41.23849332
47CAMKK21.22271851
48STK101.18635258
49IRAK31.18482174
50TIE11.17587540
51MAP3K141.16232529
52AURKB1.14853463
53BRSK21.13736614
54MAP3K51.12319836
55PINK11.10070561
56FGR1.09445230
57ILK1.08733588
58SYK1.07304478
59TGFBR21.06861278
60CDK121.05941029
61CDK71.05807339
62PIM21.04132341
63CDK41.02673123
64PTK2B1.01439537
65MAPK131.00970648
66MAP3K40.99856782
67SRPK10.99780628
68MAP3K110.99430987
69MAP3K30.99141488
70IRAK40.98260692
71MATK0.97654111
72PIM10.96645627
73IKBKE0.95769936
74PAK40.94779445
75AKT30.94291373
76BRD40.93959786
77CSNK1G30.92434082
78TESK20.92329435
79FES0.90971726
80ABL20.90284944
81TTN0.89314854
82CSNK1A1L0.87805151
83BLK0.87503491
84ITK0.86757523
85MAPK110.84585644
86TNK20.84107074
87STK160.84058875
88MAP3K80.83446030
89CSF1R0.82994540
90STK40.81088106
91FRK0.80296272
92GRK60.79929186
93NEK10.79106776
94TEC0.76982795
95PDGFRA0.76523775
96MAPKAPK30.75717168
97MUSK0.75644176
98DAPK10.74458000
99DYRK1B0.72081898
100TSSK60.71369830
101MKNK10.69989134
102PLK10.69547852
103NEK90.68305029
104HIPK20.65452910
105YES10.63858807
106PTK60.63586009
107CSNK1G20.62568080
108PRPF4B0.62214427
109IKBKB0.62019702
110CHUK0.61708751
111CHEK20.60829219
112BMPR1B0.60793222
113DAPK20.59159185
114FGFR30.59087255
115SIK30.57640118
116TXK0.57587283
117CDK60.57138080
118CHEK10.55847266
119MAP2K60.55762711
120PRKCQ0.53189252
121TTK0.53057005
122SIK10.52374110
123BRAF0.52279020
124SIK20.52274253
125CSNK1G10.52237251
126INSRR0.51561274
127ICK0.51053886
128ATM0.49746284
129AKT20.49378801
130TAOK20.47972846
131NME10.47362851
132RIPK10.46860295
133LCK0.46670485
134PRKCI0.46504345
135BRSK10.45494102
136LYN0.44271439
137CDK190.43392045
138PKN10.43146896
139MARK30.42134836
140OXSR10.41918874
141CSNK2A20.40998840
142AURKA0.40401694
143MTOR0.40250406
144RPS6KA50.39853519
145CAMKK10.39147358
146UHMK10.38331042
147CSNK2A10.33820309

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.89943131
2Ribosome_Homo sapiens_hsa030104.09081867
3Mismatch repair_Homo sapiens_hsa034303.72915887
4Base excision repair_Homo sapiens_hsa034103.24727018
5Spliceosome_Homo sapiens_hsa030403.23096282
6Proteasome_Homo sapiens_hsa030502.58877676
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.50251020
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.44391998
9Pyrimidine metabolism_Homo sapiens_hsa002402.39200500
10Nucleotide excision repair_Homo sapiens_hsa034202.26000524
11One carbon pool by folate_Homo sapiens_hsa006702.24704017
12RNA polymerase_Homo sapiens_hsa030202.23138638
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.20983662
14Homologous recombination_Homo sapiens_hsa034402.17573488
15RNA transport_Homo sapiens_hsa030132.08583469
16Primary immunodeficiency_Homo sapiens_hsa053401.80544757
17Cell cycle_Homo sapiens_hsa041101.79550252
18Regulation of autophagy_Homo sapiens_hsa041401.68517425
19Oxidative phosphorylation_Homo sapiens_hsa001901.59355966
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.58644233
21Allograft rejection_Homo sapiens_hsa053301.49733553
22Sulfur relay system_Homo sapiens_hsa041221.45660072
23Folate biosynthesis_Homo sapiens_hsa007901.41865662
24Herpes simplex infection_Homo sapiens_hsa051681.35281367
25RNA degradation_Homo sapiens_hsa030181.35246089
26Protein export_Homo sapiens_hsa030601.31122698
27Autoimmune thyroid disease_Homo sapiens_hsa053201.30692390
28Non-homologous end-joining_Homo sapiens_hsa034501.28762552
29p53 signaling pathway_Homo sapiens_hsa041151.28259183
30Antigen processing and presentation_Homo sapiens_hsa046121.26040046
31Graft-versus-host disease_Homo sapiens_hsa053321.25564850
32Systemic lupus erythematosus_Homo sapiens_hsa053221.23195225
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.20736639
34Epstein-Barr virus infection_Homo sapiens_hsa051691.18982706
35Fanconi anemia pathway_Homo sapiens_hsa034601.18925709
36mRNA surveillance pathway_Homo sapiens_hsa030151.16589513
37Selenocompound metabolism_Homo sapiens_hsa004501.16402114
38Fatty acid elongation_Homo sapiens_hsa000621.11328905
39Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.08883246
40Asthma_Homo sapiens_hsa053101.08211101
41NF-kappa B signaling pathway_Homo sapiens_hsa040641.07103871
42N-Glycan biosynthesis_Homo sapiens_hsa005101.06489528
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.06332435
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06221891
45Huntingtons disease_Homo sapiens_hsa050161.05401859
46Measles_Homo sapiens_hsa051621.03078986
47Type I diabetes mellitus_Homo sapiens_hsa049401.02664122
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.02515502
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01655863
50Viral carcinogenesis_Homo sapiens_hsa052031.00961430
51Drug metabolism - other enzymes_Homo sapiens_hsa009830.98906370
52Purine metabolism_Homo sapiens_hsa002300.98387385
53Rheumatoid arthritis_Homo sapiens_hsa053230.94613445
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93356842
55HTLV-I infection_Homo sapiens_hsa051660.92039515
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.89488229
57B cell receptor signaling pathway_Homo sapiens_hsa046620.84115779
58Acute myeloid leukemia_Homo sapiens_hsa052210.80872156
59Apoptosis_Homo sapiens_hsa042100.78985136
60Hepatitis B_Homo sapiens_hsa051610.77511550
61Legionellosis_Homo sapiens_hsa051340.77499462
62Shigellosis_Homo sapiens_hsa051310.76683580
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75334869
64Phototransduction_Homo sapiens_hsa047440.74592925
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73538740
66Lysosome_Homo sapiens_hsa041420.73435278
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.72866265
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72594764
69Leishmaniasis_Homo sapiens_hsa051400.70819477
70Peroxisome_Homo sapiens_hsa041460.70024210
71Chronic myeloid leukemia_Homo sapiens_hsa052200.69678123
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.69111469
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.67793731
74Thyroid cancer_Homo sapiens_hsa052160.67063738
75Basal transcription factors_Homo sapiens_hsa030220.65155080
76Pentose phosphate pathway_Homo sapiens_hsa000300.64348148
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64097764
78Influenza A_Homo sapiens_hsa051640.64094541
79Lysine degradation_Homo sapiens_hsa003100.63920108
80Collecting duct acid secretion_Homo sapiens_hsa049660.63881333
81Small cell lung cancer_Homo sapiens_hsa052220.63277288
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61324031
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60374305
84Biosynthesis of amino acids_Homo sapiens_hsa012300.59549255
85Hematopoietic cell lineage_Homo sapiens_hsa046400.57749961
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.57403583
87Butanoate metabolism_Homo sapiens_hsa006500.57299386
88Notch signaling pathway_Homo sapiens_hsa043300.56638193
892-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53324552
90Viral myocarditis_Homo sapiens_hsa054160.53090096
91Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52718748
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52236293
93Tuberculosis_Homo sapiens_hsa051520.51286064
94Alzheimers disease_Homo sapiens_hsa050100.51278371
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50380492
96T cell receptor signaling pathway_Homo sapiens_hsa046600.49989713
97Other glycan degradation_Homo sapiens_hsa005110.49078452
98Intestinal immune network for IgA production_Homo sapiens_hsa046720.49054780
99Carbon metabolism_Homo sapiens_hsa012000.49030935
100MicroRNAs in cancer_Homo sapiens_hsa052060.47284792
101Galactose metabolism_Homo sapiens_hsa000520.45983103
102Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45664080
103Alcoholism_Homo sapiens_hsa050340.45524422
104Caffeine metabolism_Homo sapiens_hsa002320.44121299
105Toll-like receptor signaling pathway_Homo sapiens_hsa046200.44087418
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.43623186
107Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43568286
108Insulin resistance_Homo sapiens_hsa049310.43384124
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42709992
110Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42352651
111Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42086138
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41228579
113Metabolic pathways_Homo sapiens_hsa011000.40469261
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39819187
115Jak-STAT signaling pathway_Homo sapiens_hsa046300.37969497
116Bladder cancer_Homo sapiens_hsa052190.36352817
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.35843094
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.34830654
119Osteoclast differentiation_Homo sapiens_hsa043800.33834497
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33309953
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32887112
122Ether lipid metabolism_Homo sapiens_hsa005650.32436174
123Fatty acid degradation_Homo sapiens_hsa000710.32227158
124Leukocyte transendothelial migration_Homo sapiens_hsa046700.32216000
125Toxoplasmosis_Homo sapiens_hsa051450.32013805
126Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31227349
127Colorectal cancer_Homo sapiens_hsa052100.30882997
128Oocyte meiosis_Homo sapiens_hsa041140.30690526
129Non-small cell lung cancer_Homo sapiens_hsa052230.30608926
130Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.30481204
131Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28579264
132Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.26383631
133VEGF signaling pathway_Homo sapiens_hsa043700.25804494
134Parkinsons disease_Homo sapiens_hsa050120.25015790
135TNF signaling pathway_Homo sapiens_hsa046680.24666901

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