ILDR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1retinal rod cell development (GO:0046548)5.47866937
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.27441118
3retinal cone cell development (GO:0046549)4.93480937
4vocalization behavior (GO:0071625)4.76868702
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.71833248
6glutamate secretion (GO:0014047)4.70433089
7locomotory exploration behavior (GO:0035641)4.54837198
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.52156705
9synaptic vesicle maturation (GO:0016188)4.41848007
10synaptic vesicle exocytosis (GO:0016079)4.34654690
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.31665911
12regulation of glutamate receptor signaling pathway (GO:1900449)4.30159446
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.26613648
14neuronal stem cell maintenance (GO:0097150)4.22527662
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.17593449
16protein localization to synapse (GO:0035418)4.06310372
17regulation of synaptic vesicle exocytosis (GO:2000300)3.97879968
18neurotransmitter-gated ion channel clustering (GO:0072578)3.96893069
19retinal ganglion cell axon guidance (GO:0031290)3.95701178
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.90374696
21neuron cell-cell adhesion (GO:0007158)3.85856356
22gamma-aminobutyric acid transport (GO:0015812)3.85615476
23neurotransmitter secretion (GO:0007269)3.81732939
24glutamate receptor signaling pathway (GO:0007215)3.80388935
25neuron fate determination (GO:0048664)3.76675753
26synaptic transmission, glutamatergic (GO:0035249)3.73266513
27regulation of neuronal synaptic plasticity (GO:0048168)3.73110765
28pyrimidine nucleobase catabolic process (GO:0006208)3.72821070
29regulation of long-term neuronal synaptic plasticity (GO:0048169)3.72734345
30proline transport (GO:0015824)3.69398650
31exploration behavior (GO:0035640)3.67146968
32regulation of synaptic vesicle transport (GO:1902803)3.62685459
33appendage development (GO:0048736)3.50756246
34limb development (GO:0060173)3.50756246
35layer formation in cerebral cortex (GO:0021819)3.42480278
36neuronal action potential propagation (GO:0019227)3.42476911
37central nervous system myelination (GO:0022010)3.41807680
38axon ensheathment in central nervous system (GO:0032291)3.41807680
39neuron-neuron synaptic transmission (GO:0007270)3.40128274
40nonmotile primary cilium assembly (GO:0035058)3.36903350
41neuron recognition (GO:0008038)3.34359818
42dendritic spine morphogenesis (GO:0060997)3.33563535
43limb bud formation (GO:0060174)3.26883798
44cerebral cortex radially oriented cell migration (GO:0021799)3.25625806
45cellular potassium ion homeostasis (GO:0030007)3.23846201
46central nervous system projection neuron axonogenesis (GO:0021952)3.22743747
47nephron tubule morphogenesis (GO:0072078)3.22584654
48nephron epithelium morphogenesis (GO:0072088)3.22584654
49regulation of excitatory postsynaptic membrane potential (GO:0060079)3.22452487
50gamma-aminobutyric acid signaling pathway (GO:0007214)3.20320158
51long-term memory (GO:0007616)3.17576972
52cell proliferation in forebrain (GO:0021846)3.16946847
53neurotransmitter transport (GO:0006836)3.16512725
54photoreceptor cell development (GO:0042461)3.12761378
55regulation of synaptic plasticity (GO:0048167)3.12434720
56regulation of postsynaptic membrane potential (GO:0060078)3.11469368
57axonal fasciculation (GO:0007413)3.07550066
58long-term synaptic potentiation (GO:0060291)3.07343332
59negative regulation of astrocyte differentiation (GO:0048712)3.06338833
60positive regulation of membrane potential (GO:0045838)3.06063412
61cranial nerve development (GO:0021545)3.05182018
62regulation of synapse structural plasticity (GO:0051823)3.04998032
63tongue development (GO:0043586)3.02829772
64eye photoreceptor cell development (GO:0042462)3.00286778
65regulation of neurotransmitter levels (GO:0001505)3.00226596
66nucleobase catabolic process (GO:0046113)2.97934236
67postsynaptic membrane organization (GO:0001941)2.97188906
68regulation of dendritic spine morphogenesis (GO:0061001)2.96376150
69negative regulation of cytosolic calcium ion concentration (GO:0051481)2.95453747
70positive regulation of gastrulation (GO:2000543)2.94604658
71regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.94119300
72G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.93825871
73regulation of synaptic transmission, glutamatergic (GO:0051966)2.93355904
74presynaptic membrane assembly (GO:0097105)2.93102850
75positive regulation of synapse assembly (GO:0051965)2.90840454
76retina layer formation (GO:0010842)2.89273911
77positive regulation of synapse maturation (GO:0090129)2.89226315
78olfactory bulb development (GO:0021772)2.89225914
79innervation (GO:0060384)2.88741330
80activation of protein kinase A activity (GO:0034199)2.87330074
81mechanosensory behavior (GO:0007638)2.86635514
82lateral sprouting from an epithelium (GO:0060601)2.84889168
83negative regulation of synaptic transmission, GABAergic (GO:0032229)2.83625772
84alanine transport (GO:0032328)2.83552953
85positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.81989122
86cellular response to cholesterol (GO:0071397)2.81028760
87inner ear receptor stereocilium organization (GO:0060122)2.80911888
88forebrain neuron differentiation (GO:0021879)2.80273927
89response to histamine (GO:0034776)2.78691755
90erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.78506247
91L-phenylalanine catabolic process (GO:0006559)2.78506247
92transmission of nerve impulse (GO:0019226)2.76864204
93otic vesicle formation (GO:0030916)2.76762439
94glomerular visceral epithelial cell development (GO:0072015)2.76672006
95hindbrain development (GO:0030902)2.75121555
96behavioral defense response (GO:0002209)2.74828266
97behavioral fear response (GO:0001662)2.74828266
98detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.73824739
99photoreceptor cell maintenance (GO:0045494)2.73526392
100establishment of nucleus localization (GO:0040023)2.72696684
101sodium ion export (GO:0071436)2.72002284
102dicarboxylic acid biosynthetic process (GO:0043650)2.71624197
103membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.71328199
104neuromuscular process controlling balance (GO:0050885)2.70536772
105dendrite morphogenesis (GO:0048813)2.70161909
106artery development (GO:0060840)2.69948311
107regulation of glutamate secretion (GO:0014048)2.68949831
108regulation of neurotransmitter secretion (GO:0046928)2.68687671
109glomerulus development (GO:0032835)2.68549466
110behavioral response to nicotine (GO:0035095)2.68503161
111negative regulation of glial cell differentiation (GO:0045686)2.68192763
112negative regulation of oligodendrocyte differentiation (GO:0048715)2.67860480
113synaptic vesicle endocytosis (GO:0048488)2.67828316
114cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.65678102
115startle response (GO:0001964)2.64761235
116somite development (GO:0061053)2.64376284
117glutamate metabolic process (GO:0006536)2.64179363
118regulation of dendritic spine development (GO:0060998)2.63934383
119central nervous system neuron axonogenesis (GO:0021955)2.63505510
120embryonic retina morphogenesis in camera-type eye (GO:0060059)2.62079254
121regulation of vesicle fusion (GO:0031338)2.61778293
122positive regulation of dendritic spine morphogenesis (GO:0061003)2.61637482
123presynaptic membrane organization (GO:0097090)2.60237226
124renal tubule morphogenesis (GO:0061333)2.59835435
125epithelial cell differentiation involved in kidney development (GO:0035850)2.59710620
126cerebellar Purkinje cell differentiation (GO:0021702)2.59696823
127smoothened signaling pathway (GO:0007224)2.59117831
128kidney morphogenesis (GO:0060993)2.58499448
129neuroblast proliferation (GO:0007405)2.58056551
130ephrin receptor signaling pathway (GO:0048013)2.57982644
131negative regulation of sodium ion transport (GO:0010766)2.57828854
132negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.57151903
133regulation of synaptic transmission (GO:0050804)2.55356941
134regulation of non-canonical Wnt signaling pathway (GO:2000050)2.55260759
135glomerular epithelial cell development (GO:0072310)2.55176840
136cell differentiation involved in metanephros development (GO:0072202)2.55065169
137cell communication by electrical coupling (GO:0010644)2.55029008
138apical protein localization (GO:0045176)2.54923200
139cellular sodium ion homeostasis (GO:0006883)2.54881406
140L-phenylalanine metabolic process (GO:0006558)2.54368682
141erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.54368682
142auditory behavior (GO:0031223)2.54183257
143regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.54063403
144response to auditory stimulus (GO:0010996)2.53617445
145positive regulation of dendritic spine development (GO:0060999)2.53397468
146fear response (GO:0042596)2.53190557
147cerebellar granule cell differentiation (GO:0021707)2.52760516
148positive regulation of synaptic transmission (GO:0050806)2.52597334
149adult walking behavior (GO:0007628)2.52339209
150midbrain development (GO:0030901)2.51922396
151behavioral response to cocaine (GO:0048148)2.51845875
152social behavior (GO:0035176)2.51826634
153intraspecies interaction between organisms (GO:0051703)2.51826634
154positive regulation of synaptic transmission, GABAergic (GO:0032230)2.51812339
155neuromuscular process controlling posture (GO:0050884)2.51781601
156regulation of neurotransmitter transport (GO:0051588)2.51689149
157negative regulation of amino acid transport (GO:0051956)2.51654201
158membrane depolarization (GO:0051899)2.51644145
159lens fiber cell development (GO:0070307)2.50349533
160positive regulation of neuroblast proliferation (GO:0002052)2.50311842
161spinal cord development (GO:0021510)2.48024259
162negative regulation of dendrite development (GO:2000171)2.47626407
163cellular response to sterol (GO:0036315)2.46218953
164intraciliary transport (GO:0042073)2.46146381
165cell-cell signaling involved in cell fate commitment (GO:0045168)2.45939994
166regulation of timing of cell differentiation (GO:0048505)2.44289182
167regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.43253922
168thalamus development (GO:0021794)2.43096892
169regulation of oligodendrocyte differentiation (GO:0048713)2.41928995
170regulation of synapse assembly (GO:0051963)2.41825138
171substrate-independent telencephalic tangential migration (GO:0021826)2.41564246
172substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.41564246
173eye photoreceptor cell differentiation (GO:0001754)2.41510049
174photoreceptor cell differentiation (GO:0046530)2.41510049
175negative regulation of smoothened signaling pathway (GO:0045879)2.40102131
176positive regulation of neurological system process (GO:0031646)2.40085421
177radial glial cell differentiation (GO:0060019)2.39643638

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.28498549
2GBX2_23144817_ChIP-Seq_PC3_Human3.48642631
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.90100620
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.85118484
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.73592899
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.52230382
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.52230382
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.49358620
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46338689
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.38809095
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.37847322
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.35124911
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.32248546
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.28206450
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.24801006
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.19805002
17DROSHA_22980978_ChIP-Seq_HELA_Human2.16900760
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.16782621
19REST_21632747_ChIP-Seq_MESCs_Mouse2.16003275
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.05691789
21FUS_26573619_Chip-Seq_HEK293_Human1.98286631
22EZH2_27294783_Chip-Seq_ESCs_Mouse1.96864071
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.96326221
24RARB_27405468_Chip-Seq_BRAIN_Mouse1.89734068
25MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.89192656
26* RNF2_27304074_Chip-Seq_ESCs_Mouse1.87287949
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.86686570
28TAF15_26573619_Chip-Seq_HEK293_Human1.84584629
29ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.82042249
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75716374
31IGF1R_20145208_ChIP-Seq_DFB_Human1.74778621
32REST_18959480_ChIP-ChIP_MESCs_Mouse1.72268089
33EWS_26573619_Chip-Seq_HEK293_Human1.70944254
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68841372
35RNF2_27304074_Chip-Seq_NSC_Mouse1.68252529
36RBPJ_22232070_ChIP-Seq_NCS_Mouse1.67810574
37* SMAD4_21799915_ChIP-Seq_A2780_Human1.64306682
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.64108605
39AR_21572438_ChIP-Seq_LNCaP_Human1.63726488
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.60628948
41CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.60295497
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59818077
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.57768287
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.56772660
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56610844
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.49886659
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45839874
48VDR_22108803_ChIP-Seq_LS180_Human1.45568371
49P300_19829295_ChIP-Seq_ESCs_Human1.43211233
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.43036515
51TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40378112
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37319910
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37252121
54PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34798052
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33291997
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.32301407
57SOX2_21211035_ChIP-Seq_LN229_Gbm1.31138761
58* NANOG_18555785_Chip-Seq_ESCs_Mouse1.30932798
59CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.30436109
60RXR_22158963_ChIP-Seq_LIVER_Mouse1.29897992
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29504326
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28203410
63NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27488492
64CBP_20019798_ChIP-Seq_JUKART_Human1.27201225
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27201225
66AR_25329375_ChIP-Seq_VCAP_Human1.26223533
67KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.25883769
68NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.24759680
69CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22840956
70ER_23166858_ChIP-Seq_MCF-7_Human1.21930895
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20919779
72TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.20397603
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20228201
74STAT3_23295773_ChIP-Seq_U87_Human1.19842421
75TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19513882
76LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19454772
77ZNF274_21170338_ChIP-Seq_K562_Hela1.19039923
78* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18595375
79STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.18569655
80ARNT_22903824_ChIP-Seq_MCF-7_Human1.18462346
81* RING1B_27294783_Chip-Seq_ESCs_Mouse1.18453865
82SOX9_26525672_Chip-Seq_HEART_Mouse1.18233083
83EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17710716
84* LXR_22158963_ChIP-Seq_LIVER_Mouse1.17646764
85CBX2_27304074_Chip-Seq_ESCs_Mouse1.17333522
86AR_19668381_ChIP-Seq_PC3_Human1.15818257
87FLI1_27457419_Chip-Seq_LIVER_Mouse1.14920663
88AHR_22903824_ChIP-Seq_MCF-7_Human1.14694107
89SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14467220
90* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14411544
91PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14351190
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12956934
93P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11354278
94MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10962967
95TBL1_22424771_ChIP-Seq_293T_Human1.10813385
96GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10796854
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09957206
98FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.09716048
99SMAD_19615063_ChIP-ChIP_OVARY_Human1.08922173
100BCAT_22108803_ChIP-Seq_LS180_Human1.08782638
101ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07936931
102TP53_18474530_ChIP-ChIP_U2OS_Human1.07297228
103TBX3_20139965_ChIP-Seq_MESCs_Mouse1.06306761
104* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05317753
105TBX3_20139965_ChIP-Seq_ESCs_Mouse1.05010781
106EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04712678
107TP53_16413492_ChIP-PET_HCT116_Human1.03500006
108TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01432534
109PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01142357
110SMAD4_21741376_ChIP-Seq_HESCs_Human1.00921694
111* P53_22387025_ChIP-Seq_ESCs_Mouse1.00427144
112TCF4_23295773_ChIP-Seq_U87_Human0.99482159
113* RING1B_27294783_Chip-Seq_NPCs_Mouse0.98897676
114UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98505165
115YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97859747
116TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96943542
117BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96800240
118BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96779506
119SMAD3_21741376_ChIP-Seq_HESCs_Human0.96208897
120ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96166953
121POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96080399
122RUNX2_22187159_ChIP-Seq_PCA_Human0.95477613
123MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95033510
124WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.94082602
125CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93934661
126DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92768309
127* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.91897200
128JUN_21703547_ChIP-Seq_K562_Human0.90981552
129* RXR_22108803_ChIP-Seq_LS180_Human0.88604914
130PRDM14_20953172_ChIP-Seq_ESCs_Human0.86363631
131* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86242925
132TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86186956
133POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86186956
134EP300_21415370_ChIP-Seq_HL-1_Mouse0.85785014

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.10378819
2MP0003880_abnormal_central_pattern4.56126430
3MP0003635_abnormal_synaptic_transmissio3.83044437
4MP0009745_abnormal_behavioral_response3.30861968
5MP0002063_abnormal_learning/memory/cond3.09686589
6MP0003136_yellow_coat_color3.06677430
7MP0002064_seizures2.98521850
8MP0004270_analgesia2.97175955
9MP0001968_abnormal_touch/_nociception2.81333814
10MP0005248_abnormal_Harderian_gland2.77204888
11MP0005360_urolithiasis2.74722545
12MP0006292_abnormal_olfactory_placode2.74417630
13MP0001346_abnormal_lacrimal_gland2.68410026
14MP0009046_muscle_twitch2.67005690
15MP0002139_abnormal_hepatobiliary_system2.61349946
16MP0002572_abnormal_emotion/affect_behav2.61030060
17MP0000566_synostosis2.49144081
18MP0001501_abnormal_sleep_pattern2.33350206
19MP0001486_abnormal_startle_reflex2.26222930
20MP0002272_abnormal_nervous_system2.21033878
21MP0002736_abnormal_nociception_after2.17216493
22MP0005085_abnormal_gallbladder_physiolo2.16929395
23MP0005423_abnormal_somatic_nervous2.12481183
24MP0001440_abnormal_grooming_behavior2.05909332
25MP0008875_abnormal_xenobiotic_pharmacok2.05625995
26MP0002734_abnormal_mechanical_nocicepti2.03934212
27MP0009780_abnormal_chondrocyte_physiolo2.03528381
28MP0003329_amyloid_beta_deposits2.02975922
29MP0002653_abnormal_ependyma_morphology2.01051197
30MP0005253_abnormal_eye_physiology1.87338448
31MP0000631_abnormal_neuroendocrine_gland1.84376013
32MP0005365_abnormal_bile_salt1.84162774
33MP0006072_abnormal_retinal_apoptosis1.77345681
34MP0002067_abnormal_sensory_capabilities1.75712278
35MP0010030_abnormal_orbit_morphology1.75082634
36MP0004858_abnormal_nervous_system1.74327608
37MP0001293_anophthalmia1.72112027
38MP0002822_catalepsy1.71467017
39MP0000778_abnormal_nervous_system1.70098918
40MP0002938_white_spotting1.66622892
41MP0002735_abnormal_chemical_nociception1.65408625
42MP0002102_abnormal_ear_morphology1.64558949
43MP0002733_abnormal_thermal_nociception1.61333061
44MP0002697_abnormal_eye_size1.61228982
45MP0006276_abnormal_autonomic_nervous1.57586186
46MP0000049_abnormal_middle_ear1.56247157
47MP0008789_abnormal_olfactory_epithelium1.56243997
48MP0002233_abnormal_nose_morphology1.55511783
49MP0001485_abnormal_pinna_reflex1.53952893
50MP0002557_abnormal_social/conspecific_i1.53629865
51MP0004885_abnormal_endolymph1.50217402
52MP0002234_abnormal_pharynx_morphology1.47282954
53MP0000026_abnormal_inner_ear1.45940362
54MP0001286_abnormal_eye_development1.45433596
55MP0001970_abnormal_pain_threshold1.44852410
56MP0005646_abnormal_pituitary_gland1.44123066
57MP0005195_abnormal_posterior_eye1.44057131
58MP0003879_abnormal_hair_cell1.44034350
59MP0004742_abnormal_vestibular_system1.42029124
60MP0005499_abnormal_olfactory_system1.41969722
61MP0005394_taste/olfaction_phenotype1.41969722
62MP0010329_abnormal_lipoprotein_level1.41049183
63MP0005391_vision/eye_phenotype1.39937163
64MP0005167_abnormal_blood-brain_barrier1.39860594
65MP0003633_abnormal_nervous_system1.38886402
66MP0002638_abnormal_pupillary_reflex1.38177275
67MP0003690_abnormal_glial_cell1.37880837
68MP0003121_genomic_imprinting1.37024593
69MP0003937_abnormal_limbs/digits/tail_de1.35838648
70MP0005386_behavior/neurological_phenoty1.34161413
71MP0004924_abnormal_behavior1.34161413
72MP0001299_abnormal_eye_distance/1.32803737
73MP0005332_abnormal_amino_acid1.32335649
74MP0003938_abnormal_ear_development1.31388680
75MP0002184_abnormal_innervation1.30679954
76MP0002752_abnormal_somatic_nervous1.30036334
77MP0000537_abnormal_urethra_morphology1.29140994
78MP0004811_abnormal_neuron_physiology1.26092153
79MP0002909_abnormal_adrenal_gland1.24435222
80MP0003861_abnormal_nervous_system1.24219051
81MP0003119_abnormal_digestive_system1.22882621
82MP0000428_abnormal_craniofacial_morphol1.21968907
83MP0002066_abnormal_motor_capabilities/c1.21916990
84MP0008569_lethality_at_weaning1.21718736
85MP0000955_abnormal_spinal_cord1.20789284
86MP0001984_abnormal_olfaction1.18680573
87MP0000604_amyloidosis1.17438195
88MP0003755_abnormal_palate_morphology1.16306982
89MP0005623_abnormal_meninges_morphology1.15309674
90MP0005377_hearing/vestibular/ear_phenot1.14724120
91MP0003878_abnormal_ear_physiology1.14724120
92MP0008961_abnormal_basal_metabolism1.12866330
93MP0003631_nervous_system_phenotype1.12073414
94MP0001502_abnormal_circadian_rhythm1.11602411
95MP0005535_abnormal_body_temperature1.11091279
96MP0008872_abnormal_physiological_respon1.10841580
97MP0003252_abnormal_bile_duct1.10692143
98MP0002249_abnormal_larynx_morphology1.10015939
99MP0002882_abnormal_neuron_morphology1.09613744
100MP0009053_abnormal_anal_canal1.09206732
101MP0008874_decreased_physiological_sensi1.08360625
102MP0003122_maternal_imprinting1.07771333
103MP0005171_absent_coat_pigmentation1.06820888
104MP0002751_abnormal_autonomic_nervous1.06439661
105MP0004142_abnormal_muscle_tone1.03886996
106MP0003195_calcinosis1.01035093
107MP0003075_altered_response_to1.00423850
108MP0001177_atelectasis0.99597927
109MP0008877_abnormal_DNA_methylation0.98734927
110MP0003890_abnormal_embryonic-extraembry0.98351694
111MP0002876_abnormal_thyroid_physiology0.97884472
112MP0003787_abnormal_imprinting0.97197258
113MP0002837_dystrophic_cardiac_calcinosis0.96032498
114MP0001324_abnormal_eye_pigmentation0.94662750
115MP0002152_abnormal_brain_morphology0.93122379
116MP0002069_abnormal_eating/drinking_beha0.92690907
117MP0002092_abnormal_eye_morphology0.91135896
118MP0004133_heterotaxia0.90458901
119MP0001905_abnormal_dopamine_level0.90125521
120MP0005645_abnormal_hypothalamus_physiol0.89202168
121MP0003935_abnormal_craniofacial_develop0.87578555
122MP0005551_abnormal_eye_electrophysiolog0.86768275
123MP0009250_abnormal_appendicular_skeleto0.85856787
124MP0004043_abnormal_pH_regulation0.85081426
125MP0002928_abnormal_bile_duct0.85077109
126MP0003385_abnormal_body_wall0.84939425
127MP0000534_abnormal_ureter_morphology0.84205697
128MP0002090_abnormal_vision0.82506745
129MP0002116_abnormal_craniofacial_bone0.81597737
130MP0002118_abnormal_lipid_homeostasis0.81487178
131MP0002229_neurodegeneration0.75161078
132MP0001963_abnormal_hearing_physiology0.74363582
133MP0003632_abnormal_nervous_system0.74152502
134MP0000230_abnormal_systemic_arterial0.73131294
135MP0003283_abnormal_digestive_organ0.72872900
136MP0005187_abnormal_penis_morphology0.72426114
137MP0004019_abnormal_vitamin_homeostasis0.70076725
138MP0003634_abnormal_glial_cell0.69654308
139MP0004085_abnormal_heartbeat0.69101481
140MP0001529_abnormal_vocalization0.65473870
141MP0004130_abnormal_muscle_cell0.64045945
142MP0005584_abnormal_enzyme/coenzyme_acti0.63858552
143MP0004484_altered_response_of0.63816895
144MP0010368_abnormal_lymphatic_system0.62788629
145MP0000751_myopathy0.62286823
146MP0001765_abnormal_ion_homeostasis0.62269592
147MP0005595_abnormal_vascular_smooth0.61167263
148MP0000013_abnormal_adipose_tissue0.59632001
149MP0010234_abnormal_vibrissa_follicle0.58663342
150MP0000920_abnormal_myelination0.56564801
151MP0000569_abnormal_digit_pigmentation0.55126660
152MP0004233_abnormal_muscle_weight0.54765553
153MP0005083_abnormal_biliary_tract0.54361770
154MP0003868_abnormal_feces_composition0.54036853

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.15062385
2Myokymia (HP:0002411)5.19457652
3Focal seizures (HP:0007359)4.97968624
4Hyperventilation (HP:0002883)4.28519041
5Epileptic encephalopathy (HP:0200134)4.16902439
6Septo-optic dysplasia (HP:0100842)3.97820729
7Atonic seizures (HP:0010819)3.97756030
8Visual hallucinations (HP:0002367)3.93767641
9Absence seizures (HP:0002121)3.87759227
10Deep venous thrombosis (HP:0002625)3.80930709
11Generalized tonic-clonic seizures (HP:0002069)3.72168312
12Oligodactyly (hands) (HP:0001180)3.62442422
13Progressive cerebellar ataxia (HP:0002073)3.52983790
14Dialeptic seizures (HP:0011146)3.44770690
15Febrile seizures (HP:0002373)3.42134934
16Intestinal atresia (HP:0011100)3.25481529
17Status epilepticus (HP:0002133)3.20013632
18Optic nerve hypoplasia (HP:0000609)3.01557424
19Impaired vibration sensation in the lower limbs (HP:0002166)2.98499100
20Neurofibrillary tangles (HP:0002185)2.98465790
21Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.98196236
22Short 4th metacarpal (HP:0010044)2.98196236
23Cerebral inclusion bodies (HP:0100314)2.95424192
24Dysdiadochokinesis (HP:0002075)2.95141362
25True hermaphroditism (HP:0010459)2.93408025
26Broad-based gait (HP:0002136)2.93095800
27Oligodactyly (HP:0012165)2.92585307
28Poor eye contact (HP:0000817)2.92261644
29Esophageal atresia (HP:0002032)2.90593042
30Action tremor (HP:0002345)2.85295971
31Anophthalmia (HP:0000528)2.85105141
32Abnormal social behavior (HP:0012433)2.81108498
33Impaired social interactions (HP:0000735)2.81108498
34Abnormality of the diencephalon (HP:0010662)2.80906879
35Nephronophthisis (HP:0000090)2.76534674
36Dysmetria (HP:0001310)2.75279718
37Gastrointestinal atresia (HP:0002589)2.74918223
38Bony spicule pigmentary retinopathy (HP:0007737)2.74245230
39Abnormality of the 4th metacarpal (HP:0010012)2.73171885
40Drooling (HP:0002307)2.70946812
41Excessive salivation (HP:0003781)2.70946812
42Abnormality of the lower motor neuron (HP:0002366)2.70894242
43Abnormal eating behavior (HP:0100738)2.68552907
44Supranuclear gaze palsy (HP:0000605)2.64008481
45Increased circulating renin level (HP:0000848)2.63146305
46Abnormality of aromatic amino acid family metabolism (HP:0004338)2.60639531
47Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.59446891
48Postural instability (HP:0002172)2.59233999
49Amblyopia (HP:0000646)2.59067882
50Urinary bladder sphincter dysfunction (HP:0002839)2.58410608
51Gaze-evoked nystagmus (HP:0000640)2.56608119
52Hyperlipoproteinemia (HP:0010980)2.55727529
53Anxiety (HP:0000739)2.55622532
54Abnormality of the ischium (HP:0003174)2.53698285
55Medial flaring of the eyebrow (HP:0010747)2.50543269
56Epileptiform EEG discharges (HP:0011182)2.50501379
57Depression (HP:0000716)2.49979730
58Vitreoretinal degeneration (HP:0000655)2.48461686
59Pancreatic fibrosis (HP:0100732)2.48132613
60Focal segmental glomerulosclerosis (HP:0000097)2.47437377
61Xanthomatosis (HP:0000991)2.43326308
62Hemiplegia (HP:0002301)2.42690135
63Chronic hepatic failure (HP:0100626)2.42139176
64Abnormality of the renal medulla (HP:0100957)2.40016499
65Papilledema (HP:0001085)2.39027638
66Abnormality of midbrain morphology (HP:0002418)2.38272771
67Molar tooth sign on MRI (HP:0002419)2.38272771
68Torticollis (HP:0000473)2.37545554
69Pancreatic cysts (HP:0001737)2.36755917
70Blue irides (HP:0000635)2.34001882
71Scanning speech (HP:0002168)2.32584161
72Cutaneous finger syndactyly (HP:0010554)2.32370441
73Genetic anticipation (HP:0003743)2.31214493
74Intrahepatic cholestasis (HP:0001406)2.30699554
75Hypoplastic ischia (HP:0003175)2.30236934
76Prolonged partial thromboplastin time (HP:0003645)2.29857376
77EEG with generalized epileptiform discharges (HP:0011198)2.28568654
78Focal dystonia (HP:0004373)2.28519451
79Absent septum pellucidum (HP:0001331)2.26531280
80Confusion (HP:0001289)2.24716745
81Gait imbalance (HP:0002141)2.24514236
82Fibular hypoplasia (HP:0003038)2.23387655
83Intention tremor (HP:0002080)2.22825764
84Generalized myoclonic seizures (HP:0002123)2.22745270
85Ankle clonus (HP:0011448)2.22555863
86Hemiparesis (HP:0001269)2.21136271
87Truncal ataxia (HP:0002078)2.20366273
88Hypobetalipoproteinemia (HP:0003563)2.18736059
89Chorioretinal atrophy (HP:0000533)2.17923328
90Volvulus (HP:0002580)2.17713904
91Impaired vibratory sensation (HP:0002495)2.16849840
92Mutism (HP:0002300)2.16656787
93Hemivertebrae (HP:0002937)2.15819413
94Glomerulosclerosis (HP:0000096)2.15793714
95Renal hypoplasia (HP:0000089)2.15555850
96Hypsarrhythmia (HP:0002521)2.14677980
97Fair hair (HP:0002286)2.12637400
98Aqueductal stenosis (HP:0002410)2.11583051
99Preaxial foot polydactyly (HP:0001841)2.11342654
100Ketosis (HP:0001946)2.08948314
101Genital tract atresia (HP:0001827)2.07797682
102Craniofacial dystonia (HP:0012179)2.07406863
103Vaginal atresia (HP:0000148)2.07269642
104Polyphagia (HP:0002591)2.07079228
105Urinary urgency (HP:0000012)2.06045058
106Complement deficiency (HP:0004431)2.05427079
107Congenital primary aphakia (HP:0007707)2.05119742
108Rib fusion (HP:0000902)2.04708921
109Attenuation of retinal blood vessels (HP:0007843)2.04289329
110Abnormality of the labia minora (HP:0012880)2.04268565
111Diplopia (HP:0000651)2.03737021
112Abnormality of binocular vision (HP:0011514)2.03737021
113Abnormality of monocarboxylic acid metabolism (HP:0010996)2.03652044
114Sclerocornea (HP:0000647)2.02471913
115Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.01545851
116Pendular nystagmus (HP:0012043)2.01305856
117Termporal pattern (HP:0011008)2.00800934
118Insidious onset (HP:0003587)2.00800934
119Spontaneous abortion (HP:0005268)2.00000363
120Sensorimotor neuropathy (HP:0007141)1.99651378
121Delayed CNS myelination (HP:0002188)1.99197174
122Spastic gait (HP:0002064)1.99092279
123Hyperglycinemia (HP:0002154)1.97483063
124Bradykinesia (HP:0002067)1.96998587
125Postaxial hand polydactyly (HP:0001162)1.95696694
126Arthropathy (HP:0003040)1.95671418
127Cerebellar dysplasia (HP:0007033)1.95587610
128Maternal diabetes (HP:0009800)1.95393787
129Stereotypic behavior (HP:0000733)1.95378196
130Split foot (HP:0001839)1.95357421
131Agitation (HP:0000713)1.95071212
132Abnormality of the septum pellucidum (HP:0007375)1.94234665
133Gout (HP:0001997)1.93321114
134Central scotoma (HP:0000603)1.92753870
135Glomerulonephritis (HP:0000099)1.92608402
136Absent speech (HP:0001344)1.91978225
137Impaired smooth pursuit (HP:0007772)1.90766830
138Abnormality of glutamine family amino acid metabolism (HP:0010902)1.90540013
139Cutaneous syndactyly (HP:0012725)1.88453215
140Inability to walk (HP:0002540)1.88057209
141Abnormality of the renal cortex (HP:0011035)1.87027683
142Mixed hearing impairment (HP:0000410)1.86766819
143Preaxial hand polydactyly (HP:0001177)1.86652093
144Papillary thyroid carcinoma (HP:0002895)1.86505150
145Rapidly progressive (HP:0003678)1.86184339
146Renal dysplasia (HP:0000110)1.85524993
147Dysmetric saccades (HP:0000641)1.85350973
148Anencephaly (HP:0002323)1.84834264
149Growth hormone deficiency (HP:0000824)1.84337141
150Abnormality of the corticospinal tract (HP:0002492)1.84076182
151Hyperthyroidism (HP:0000836)1.83465582
152Generalized hypopigmentation of hair (HP:0011358)1.81862723
153Bronchomalacia (HP:0002780)1.81785214
154Tubulointerstitial nephritis (HP:0001970)1.80797069
155Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.80626577
156Turricephaly (HP:0000262)1.80601581
157Pachygyria (HP:0001302)1.80076632
158High anterior hairline (HP:0009890)1.79118770
159Neonatal onset (HP:0003623)1.79113943
160Aplasia/Hypoplasia of the fibula (HP:0006492)1.78487399
161Bilateral microphthalmos (HP:0007633)1.78123797
162Thickened helices (HP:0000391)1.78062943
163Congenital stationary night blindness (HP:0007642)1.77547441
164Type II lissencephaly (HP:0007260)1.77269438
165Nephrogenic diabetes insipidus (HP:0009806)1.77061208
166Abnormality of salivation (HP:0100755)1.76731923
167Epidermoid cyst (HP:0200040)1.76573217
168Ketoacidosis (HP:0001993)1.75973016
169Psychosis (HP:0000709)1.75843608
170Megalencephaly (HP:0001355)1.75314652
171Chorioretinal coloboma (HP:0000567)1.74932868
172Hepatoblastoma (HP:0002884)1.74113292
173Partial duplication of thumb phalanx (HP:0009944)1.74035166
174Hypoplasia of the ulna (HP:0003022)1.72946290
175Holoprosencephaly (HP:0001360)1.72587661
176Poor coordination (HP:0002370)1.72259354
177Aplasia/Hypoplasia of the tongue (HP:0010295)1.72035128
178Neonatal short-limb short stature (HP:0008921)1.71841128
179Cystic liver disease (HP:0006706)1.71738491
180Postaxial foot polydactyly (HP:0001830)1.70421615
181Ectopic kidney (HP:0000086)1.69833635
182Aplasia/Hypoplasia of the sternum (HP:0006714)1.66407073
183Colon cancer (HP:0003003)1.65658422
184Medulloblastoma (HP:0002885)1.63565232
185Midline defect of the nose (HP:0004122)1.62678198
186Lissencephaly (HP:0001339)1.62328563
187Abolished electroretinogram (ERG) (HP:0000550)1.62179829
188Abnormality of the antihelix (HP:0009738)1.61470693
189Scotoma (HP:0000575)1.59881285

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.63347580
2EPHA44.37157853
3MAP3K93.47603407
4MAP3K43.13712671
5BMPR1B2.75680792
6DAPK22.75431312
7MAP2K72.44200378
8MAP2K42.41340186
9MKNK22.39340762
10MINK12.37496415
11CASK2.26903097
12MARK12.18014575
13FRK2.14697455
14NTRK22.05923893
15TSSK62.01407117
16MAP3K121.99981250
17PAK61.99958689
18KSR21.89552166
19NTRK11.87137158
20WEE11.81410707
21KSR11.78680562
22DAPK11.65738417
23MAPK151.63504881
24PLK21.60967321
25TNIK1.59269107
26PNCK1.59049583
27OXSR11.58969696
28PRKD31.54797143
29MKNK11.54730611
30RIPK41.53025245
31CDK191.44893317
32CAMKK11.39641754
33TGFBR11.39186084
34CDK51.36916402
35SIK21.31181757
36CDK81.30994625
37PRKCG1.30192948
38DYRK21.27202241
39TAF11.26089611
40MAP3K131.25132208
41STK381.23498024
42GRK51.14196172
43STK38L1.13466578
44CAMK2B1.13313440
45MAPK131.13025029
46CAMK2A1.11853574
47MAP3K21.10017571
48LATS21.09335364
49FES1.08520554
50BCR1.06918197
51PAK31.06179804
52EPHA31.01447017
53MAP4K21.01124519
54PKN10.98824132
55TYRO30.96876989
56MAP3K100.96704535
57ARAF0.95048361
58WNK40.94901880
59SGK2230.93008174
60SGK4940.93008174
61ERBB20.92650910
62CSNK1G20.89533017
63FGFR10.89519623
64STK110.88643171
65PRPF4B0.88328682
66MAP3K70.87692419
67WNK30.87296058
68SGK20.87205462
69PTK2B0.86728579
70FER0.85125469
71CAMK10.81437880
72CDK30.81351205
73CDC70.80678027
74CSNK1G10.79210374
75PRKCH0.78809374
76SGK10.78722926
77VRK10.77991570
78CDK180.74631071
79SGK30.73819547
80EPHB20.73809490
81CDK150.73284979
82CAMK1G0.73054327
83GRK10.71455002
84CDK140.71427975
85BRD40.69817432
86UHMK10.69816604
87PLK30.68768274
88PASK0.67245471
89RET0.67197206
90NUAK10.65741324
91RAF10.64577097
92PRKCZ0.64235243
93PKN20.62720498
94PDPK10.62355631
95STK390.62119118
96CDK11A0.61958669
97ADRBK20.61910931
98MARK20.61333449
99TAOK10.61154695
100PINK10.60690876
101FGFR20.60204897
102PDK10.60029718
103CAMK2G0.59856859
104ZAK0.59410399
105ERBB30.59143344
106LATS10.59129434
107BRSK20.58315323
108PRKCE0.57230061
109PLK40.56674881
110FGR0.56022231
111PHKG20.54731723
112PHKG10.54731723
113MAP2K10.52930911
114CSNK1G30.52583814
115BMPR20.52268810
116MAPK120.52169635
117RPS6KA30.52106716
118AKT30.51881592
119INSRR0.51486554
120WNK10.50730898
121DYRK1A0.49514999
122CCNB10.48567311
123MAP3K60.48033933
124CDK90.47808746
125CAMK2D0.47591869
126CAMKK20.47290753
127CAMK40.46115670
128MAP3K10.44877521
129ATM0.42929152
130PIK3CA0.42862139
131TRIM280.42831287
132LMTK20.42825071
133FYN0.42690173
134TNK20.42186403
135CSNK1D0.39026016
136MAPK100.38808591
137ROCK10.38796818
138ACVR1B0.38601679
139CSNK1A1L0.38276058
140NEK60.36978794
141PDGFRB0.35747779
142PRKG10.35549100
143ROCK20.35487153
144PRKCA0.35456763
145PRKACG0.34464800
146NLK0.33881387
147MAPK70.32913589
148STK30.32224423
149CSNK1E0.31829929

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.39610595
2Nitrogen metabolism_Homo sapiens_hsa009103.20194416
3Hedgehog signaling pathway_Homo sapiens_hsa043402.88245252
4Basal cell carcinoma_Homo sapiens_hsa052172.75699781
5Synaptic vesicle cycle_Homo sapiens_hsa047212.46197423
6GABAergic synapse_Homo sapiens_hsa047272.33318513
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.20849301
8Circadian entrainment_Homo sapiens_hsa047132.12801288
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.11671693
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.09738349
11Long-term potentiation_Homo sapiens_hsa047202.09135740
12Glutamatergic synapse_Homo sapiens_hsa047242.08444733
13Amphetamine addiction_Homo sapiens_hsa050311.94986541
14Arginine biosynthesis_Homo sapiens_hsa002201.93942273
15Morphine addiction_Homo sapiens_hsa050321.93730401
16Phototransduction_Homo sapiens_hsa047441.91255791
17Olfactory transduction_Homo sapiens_hsa047401.88231426
18Hippo signaling pathway_Homo sapiens_hsa043901.86820800
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.84340104
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.82100039
21Salivary secretion_Homo sapiens_hsa049701.75203155
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.74757224
23Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.57474599
24Insulin secretion_Homo sapiens_hsa049111.55906623
25Wnt signaling pathway_Homo sapiens_hsa043101.54133288
26Bile secretion_Homo sapiens_hsa049761.53138305
27Dopaminergic synapse_Homo sapiens_hsa047281.52721852
28Butanoate metabolism_Homo sapiens_hsa006501.49777201
29Gastric acid secretion_Homo sapiens_hsa049711.49461453
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.48994968
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.45089934
32Taste transduction_Homo sapiens_hsa047421.39708146
33Renin secretion_Homo sapiens_hsa049241.39506915
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.31630062
35Fanconi anemia pathway_Homo sapiens_hsa034601.31381646
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.28002893
37Calcium signaling pathway_Homo sapiens_hsa040201.22206099
38Cholinergic synapse_Homo sapiens_hsa047251.21755987
39Long-term depression_Homo sapiens_hsa047301.21142796
40Cocaine addiction_Homo sapiens_hsa050301.21029576
41Serotonergic synapse_Homo sapiens_hsa047261.17718819
42Oxytocin signaling pathway_Homo sapiens_hsa049211.17691890
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15336541
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14049069
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11982940
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.11789601
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09597152
48Collecting duct acid secretion_Homo sapiens_hsa049661.08644232
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08464578
50TGF-beta signaling pathway_Homo sapiens_hsa043501.04939005
51Complement and coagulation cascades_Homo sapiens_hsa046101.01372184
52Alcoholism_Homo sapiens_hsa050341.00582549
53cAMP signaling pathway_Homo sapiens_hsa040241.00510596
54GnRH signaling pathway_Homo sapiens_hsa049120.97785644
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97570835
56Axon guidance_Homo sapiens_hsa043600.96757381
57Gap junction_Homo sapiens_hsa045400.90956321
58Protein export_Homo sapiens_hsa030600.88551542
59Tryptophan metabolism_Homo sapiens_hsa003800.87494478
60Basal transcription factors_Homo sapiens_hsa030220.84765860
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83979395
62Estrogen signaling pathway_Homo sapiens_hsa049150.82358543
63Lysine degradation_Homo sapiens_hsa003100.82350804
64Type II diabetes mellitus_Homo sapiens_hsa049300.81710435
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80911534
66Melanogenesis_Homo sapiens_hsa049160.80233592
67Notch signaling pathway_Homo sapiens_hsa043300.79812329
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.77635120
69PPAR signaling pathway_Homo sapiens_hsa033200.77634752
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76914060
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76611906
72Glioma_Homo sapiens_hsa052140.72759215
73Oocyte meiosis_Homo sapiens_hsa041140.72024597
74Thyroid hormone synthesis_Homo sapiens_hsa049180.70911571
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70790927
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70625109
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.68055337
78Fatty acid degradation_Homo sapiens_hsa000710.67551692
79Folate biosynthesis_Homo sapiens_hsa007900.66777762
80Propanoate metabolism_Homo sapiens_hsa006400.65729355
81Colorectal cancer_Homo sapiens_hsa052100.65135418
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64988750
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.63623990
84Dorso-ventral axis formation_Homo sapiens_hsa043200.63458301
85Fatty acid metabolism_Homo sapiens_hsa012120.63289419
86Tight junction_Homo sapiens_hsa045300.62219906
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61402785
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61229064
89Linoleic acid metabolism_Homo sapiens_hsa005910.60606554
90Homologous recombination_Homo sapiens_hsa034400.60510298
91Ras signaling pathway_Homo sapiens_hsa040140.60133351
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60083193
93Adherens junction_Homo sapiens_hsa045200.59578461
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59249650
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57541217
96Glucagon signaling pathway_Homo sapiens_hsa049220.57478264
97Rap1 signaling pathway_Homo sapiens_hsa040150.56623606
982-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56322677
99Steroid biosynthesis_Homo sapiens_hsa001000.55402688
100MicroRNAs in cancer_Homo sapiens_hsa052060.55383487
101ErbB signaling pathway_Homo sapiens_hsa040120.54913780
102beta-Alanine metabolism_Homo sapiens_hsa004100.53909610
103Prion diseases_Homo sapiens_hsa050200.53473601
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53387959
105Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52568190
106Melanoma_Homo sapiens_hsa052180.52115972
107Peroxisome_Homo sapiens_hsa041460.51204367
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50895921
109Pyruvate metabolism_Homo sapiens_hsa006200.50685892
110Phenylalanine metabolism_Homo sapiens_hsa003600.50640125
111Pancreatic secretion_Homo sapiens_hsa049720.49855066
112Chemical carcinogenesis_Homo sapiens_hsa052040.49708994
113Non-homologous end-joining_Homo sapiens_hsa034500.48716857
114RNA degradation_Homo sapiens_hsa030180.48183038
115Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48092249
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47793807
117Dilated cardiomyopathy_Homo sapiens_hsa054140.47720772
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47647924
119Selenocompound metabolism_Homo sapiens_hsa004500.47513543
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.47331866
121Cell cycle_Homo sapiens_hsa041100.47054987
122Cardiac muscle contraction_Homo sapiens_hsa042600.45280510
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44570146
124Fatty acid biosynthesis_Homo sapiens_hsa000610.44047518
125Vibrio cholerae infection_Homo sapiens_hsa051100.43877452
126Ovarian steroidogenesis_Homo sapiens_hsa049130.43870288
127Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43127745
128Mismatch repair_Homo sapiens_hsa034300.42936491
129MAPK signaling pathway_Homo sapiens_hsa040100.42284380
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41630834
131Choline metabolism in cancer_Homo sapiens_hsa052310.39522992
132Glycerolipid metabolism_Homo sapiens_hsa005610.38681678
133Histidine metabolism_Homo sapiens_hsa003400.36226586
134ABC transporters_Homo sapiens_hsa020100.35460344
135Circadian rhythm_Homo sapiens_hsa047100.35411411
136Starch and sucrose metabolism_Homo sapiens_hsa005000.35113697
137Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33695437
138Retinol metabolism_Homo sapiens_hsa008300.33693657
139Tyrosine metabolism_Homo sapiens_hsa003500.32882802
140Cyanoamino acid metabolism_Homo sapiens_hsa004600.31610611

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