IL7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of RIG-I signaling pathway (GO:0039535)6.73662686
2eosinophil chemotaxis (GO:0048245)6.72299465
3eosinophil migration (GO:0072677)6.03469406
4regulation of vitamin D biosynthetic process (GO:0060556)5.67457696
5NIK/NF-kappaB signaling (GO:0038061)5.64387907
6regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)5.64272576
7regulation of chronic inflammatory response (GO:0002676)5.58510433
8regulation of fever generation (GO:0031620)5.33281068
9regulation of cytokine secretion involved in immune response (GO:0002739)4.86717940
10regulation of dendritic cell antigen processing and presentation (GO:0002604)4.83409566
11regulation of vitamin metabolic process (GO:0030656)4.79067815
12myoblast migration (GO:0051451)4.77227490
13response to interferon-alpha (GO:0035455)4.54314599
14regulation of heat generation (GO:0031650)4.19556730
15regulation of mononuclear cell migration (GO:0071675)4.09172190
16positive regulation of natural killer cell differentiation (GO:0032825)4.07047120
17cellular response to type I interferon (GO:0071357)4.05713830
18type I interferon signaling pathway (GO:0060337)4.05713830
19oxygen transport (GO:0015671)4.04074945
20positive regulation of antigen processing and presentation (GO:0002579)4.02323497
21negative regulation of interleukin-12 production (GO:0032695)4.00601414
22regulation of activation of Janus kinase activity (GO:0010533)4.00547801
23response to type I interferon (GO:0034340)3.96316876
24positive regulation of chemokine biosynthetic process (GO:0045080)3.95832425
25positive regulation of Cdc42 GTPase activity (GO:0043089)3.88286092
26branching involved in labyrinthine layer morphogenesis (GO:0060670)3.87047772
27regulation of T-helper 1 cell differentiation (GO:0045625)3.81434233
28mitotic metaphase plate congression (GO:0007080)3.81079430
29regulation of immunoglobulin secretion (GO:0051023)3.80844777
30cellular response to virus (GO:0098586)3.78448038
31regulation of interleukin-12 biosynthetic process (GO:0045075)3.72032083
32regulation of transforming growth factor beta2 production (GO:0032909)3.71120726
33antigen processing and presentation of endogenous antigen (GO:0019883)3.69504025
34regulation of chemokine biosynthetic process (GO:0045073)3.68528515
35lipopolysaccharide-mediated signaling pathway (GO:0031663)3.67825117
36regulation of podosome assembly (GO:0071801)3.66615376
37positive regulation of defense response to virus by host (GO:0002230)3.66034669
38positive regulation of interleukin-12 production (GO:0032735)3.60943123
39regulation of female gonad development (GO:2000194)3.55727019
40cellular response to ATP (GO:0071318)3.55173337
41positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.54621216
42germinal center formation (GO:0002467)3.52350434
43positive regulation of type 2 immune response (GO:0002830)3.51932401
44negative regulation of hormone metabolic process (GO:0032351)3.48381418
45negative regulation of hormone biosynthetic process (GO:0032353)3.48381418
46antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.46152244
47regulation of antigen processing and presentation (GO:0002577)3.44998224
48immunoglobulin mediated immune response (GO:0016064)3.44679484
49regulation of Cdc42 GTPase activity (GO:0043088)3.44657114
50macrophage activation involved in immune response (GO:0002281)3.42045369
51cellular response to interferon-alpha (GO:0035457)3.41464216
52positive regulation of cAMP-mediated signaling (GO:0043950)3.40419413
53myeloid dendritic cell differentiation (GO:0043011)3.37253521
54DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.34899300
55positive regulation of nitric oxide biosynthetic process (GO:0045429)3.34433065
56piRNA metabolic process (GO:0034587)3.33806535
57defense response to protozoan (GO:0042832)3.33531902
58response to protozoan (GO:0001562)3.33235291
59regulation of nitric oxide biosynthetic process (GO:0045428)3.33183325
60negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.31885831
61DNA damage response, signal transduction resulting in transcription (GO:0042772)3.31792905
62interferon-gamma-mediated signaling pathway (GO:0060333)3.31641879
63regulation of T-helper cell differentiation (GO:0045622)3.31122832
64positive regulation of megakaryocyte differentiation (GO:0045654)3.30093388
65chronic inflammatory response (GO:0002544)3.29330770
66tryptophan catabolic process (GO:0006569)3.25380310
67indole-containing compound catabolic process (GO:0042436)3.25380310
68indolalkylamine catabolic process (GO:0046218)3.25380310
69negative regulation of cytokine production involved in immune response (GO:0002719)3.25304597
70positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.23098797
71response to muramyl dipeptide (GO:0032495)3.22229456
72positive regulation of interferon-alpha production (GO:0032727)3.21445182
73negative regulation of viral genome replication (GO:0045071)3.21351002
74negative regulation of nitric oxide biosynthetic process (GO:0045019)3.20148058
75regulation of interleukin-8 biosynthetic process (GO:0045414)3.19117284
76regulation of interferon-beta biosynthetic process (GO:0045357)3.16844572
77regulation of membrane protein ectodomain proteolysis (GO:0051043)3.16794530
78positive regulation of acute inflammatory response (GO:0002675)3.14797391
79positive regulation of interleukin-1 beta production (GO:0032731)3.14697815
80negative regulation of homotypic cell-cell adhesion (GO:0034111)3.12428657
81female gamete generation (GO:0007292)3.11544501
82CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.10871844
83maturation of 5.8S rRNA (GO:0000460)3.09602754
84positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.08904256
85regulation of interleukin-1 secretion (GO:0050704)3.07020806
86positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.06240607
87female gonad development (GO:0008585)3.05029328
88regulation of interleukin-1 beta secretion (GO:0050706)3.03869568
89neutrophil activation involved in immune response (GO:0002283)3.03404267
90cellular response to nicotine (GO:0071316)3.02872803
91meiotic chromosome segregation (GO:0045132)3.02629325
92negative regulation of keratinocyte proliferation (GO:0010839)3.01211447
93regulation of T-helper 1 type immune response (GO:0002825)2.99878782
94regulation of inflammatory response to antigenic stimulus (GO:0002861)2.99754633
95cellular response to ethanol (GO:0071361)2.98252231
96positive regulation of hair follicle development (GO:0051798)2.98165900
97positive regulation of hair cycle (GO:0042635)2.98165900
98negative regulation of alcohol biosynthetic process (GO:1902931)2.97556818
99positive regulation of interleukin-1 beta secretion (GO:0050718)2.96504417
100intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)2.96111460
101myeloid dendritic cell activation (GO:0001773)2.95996662
102regulation of interferon-alpha production (GO:0032647)2.95915666
103cellular response to nerve growth factor stimulus (GO:1990090)2.95434040
104response to nerve growth factor (GO:1990089)2.95434040
105kynurenine metabolic process (GO:0070189)2.95217218
106positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.95059039
107cellular response to gamma radiation (GO:0071480)2.94993508
108cellular response to exogenous dsRNA (GO:0071360)2.94790028
109positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.93991321
110regulation of interferon-gamma biosynthetic process (GO:0045072)2.93903077
111metaphase plate congression (GO:0051310)2.93482955
112positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.92591543
113dendritic cell differentiation (GO:0097028)2.91715457
114regulation of meiosis (GO:0040020)2.91611416
115negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.91356033
116positive regulation of interleukin-6 production (GO:0032755)2.91217283
117positive regulation of interferon-beta production (GO:0032728)2.90637450
118cilium or flagellum-dependent cell motility (GO:0001539)2.90254147
119positive regulation of NF-kappaB import into nucleus (GO:0042346)2.90181435
120cellular response to lipopolysaccharide (GO:0071222)2.89773836
121positive regulation of interleukin-1 production (GO:0032732)2.88738119
122nerve growth factor signaling pathway (GO:0038180)2.87757082
123growth hormone receptor signaling pathway (GO:0060396)2.87598077
124oligosaccharide catabolic process (GO:0009313)2.86369986
125regulation of hypersensitivity (GO:0002883)2.85982549
126positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.84711785
127positive regulation of T-helper cell differentiation (GO:0045624)2.84263703
128Rap protein signal transduction (GO:0032486)2.83843247
129positive regulation of toll-like receptor signaling pathway (GO:0034123)2.83580444
130response to ATP (GO:0033198)2.83212769
131negative regulation of production of molecular mediator of immune response (GO:0002701)2.82003564
132regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.81987240
133regulation of interleukin-12 production (GO:0032655)2.81405251
134negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.81094195
135regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.81035661
136cellular response to molecule of bacterial origin (GO:0071219)2.80348938
137regulation of heterotypic cell-cell adhesion (GO:0034114)2.79646614
138regulation of type I interferon-mediated signaling pathway (GO:0060338)2.79451940
139cellular response to interferon-gamma (GO:0071346)2.78525335
140cellular biogenic amine catabolic process (GO:0042402)2.78493668
141amine catabolic process (GO:0009310)2.78493668
142regulation of defense response to virus by host (GO:0050691)2.78205667
143regulation of glucocorticoid metabolic process (GO:0031943)2.78079784
144meiotic cell cycle (GO:0051321)2.77126680
145interferon-gamma secretion (GO:0072643)2.76562786
146monocyte chemotaxis (GO:0002548)2.76341398
147positive regulation of humoral immune response (GO:0002922)2.75771088
148regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.74276108
149positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.74256604
150regulation of natural killer cell differentiation (GO:0032823)2.73917260
151negative regulation of growth of symbiont in host (GO:0044130)2.73124387
152negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.73124387
153modulation of growth of symbiont involved in interaction with host (GO:0044144)2.73124387
154regulation of growth of symbiont in host (GO:0044126)2.73124387
155antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.72565305
156antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.72565305
157positive regulation of interleukin-1 secretion (GO:0050716)2.71746640
158protein K6-linked ubiquitination (GO:0085020)2.71207926
159regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.70996974
160establishment of chromosome localization (GO:0051303)2.68221795
161regulation of response to interferon-gamma (GO:0060330)2.68078195
162ERK1 and ERK2 cascade (GO:0070371)2.67742981
163response to peptidoglycan (GO:0032494)2.66261078
164attachment of spindle microtubules to kinetochore (GO:0008608)2.65633321
165B cell mediated immunity (GO:0019724)2.63081283
166positive regulation of interleukin-17 production (GO:0032740)2.62910289
167positive regulation of heat generation (GO:0031652)2.62487645
168detection of other organism (GO:0098543)2.62194790
169hemidesmosome assembly (GO:0031581)2.61715501
170T-helper 1 type immune response (GO:0042088)2.60281760
171negative regulation of lipid storage (GO:0010888)2.54497968
172positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.53479275
173regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.53039522
174oocyte maturation (GO:0001556)2.51790073

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.77602118
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.61964944
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.52161486
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.34213904
5* SMAD_19615063_ChIP-ChIP_OVARY_Human3.55277762
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.15425026
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.11983589
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.01780388
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.96103368
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.84677319
11KAP1_22055183_ChIP-Seq_ESCs_Mouse2.71795217
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.46267542
13GATA1_22025678_ChIP-Seq_K562_Human2.35970191
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.29259228
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.25180520
16* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.21097684
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.13144397
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.04400500
19IGF1R_20145208_ChIP-Seq_DFB_Human1.76042946
20SUZ12_27294783_Chip-Seq_NPCs_Mouse1.71515150
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.68860748
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.66299140
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66078988
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59979747
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.59665710
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.56970940
27ESR1_20079471_ChIP-ChIP_T-47D_Human1.55257322
28VDR_24787735_ChIP-Seq_THP-1_Human1.55130297
29NFE2_27457419_Chip-Seq_LIVER_Mouse1.53178022
30GBX2_23144817_ChIP-Seq_PC3_Human1.52714172
31* NANOG_18555785_Chip-Seq_ESCs_Mouse1.52006981
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46186982
33CJUN_26792858_Chip-Seq_BT549_Human1.42587537
34TAF15_26573619_Chip-Seq_HEK293_Human1.42383282
35* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.39984519
36* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.39984519
37EZH2_27294783_Chip-Seq_NPCs_Mouse1.38975198
38TP53_16413492_ChIP-PET_HCT116_Human1.38265155
39MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37849013
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.33909368
41RUNX_20019798_ChIP-Seq_JUKART_Human1.33575935
42FOXM1_26456572_ChIP-Seq_MCF-7_Human1.28709442
43TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28124938
44NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.27467012
45NMYC_18555785_Chip-Seq_ESCs_Mouse1.26823434
46AR_21909140_ChIP-Seq_LNCAP_Human1.26314924
47* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26018129
48STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.26007981
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.25915870
50STAT3_18555785_Chip-Seq_ESCs_Mouse1.24237542
51CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.23638548
52CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.22149324
53PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21533217
54* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21341947
55NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.21286633
56FOXM1_23109430_ChIP-Seq_U2OS_Human1.20961754
57E2F1_18555785_Chip-Seq_ESCs_Mouse1.20693444
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.19419405
59EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19248200
60RUNX1_26923725_Chip-Seq_HPCs_Mouse1.18831684
61STAT1_17558387_ChIP-Seq_HELA_Human1.18236682
62CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17998156
63* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17931076
64* SOX2_18555785_Chip-Seq_ESCs_Mouse1.17697103
65* CMYC_18555785_Chip-Seq_ESCs_Mouse1.17519741
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16332541
67* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16106110
68OCT4_18555785_Chip-Seq_ESCs_Mouse1.15589196
69BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15255827
70SUZ12_18555785_Chip-Seq_ESCs_Mouse1.13230244
71SCL_19346495_ChIP-Seq_HPC-7_Human1.12656242
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12356761
73FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12112892
74KLF4_18555785_Chip-Seq_ESCs_Mouse1.11305714
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11185811
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11185811
77FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10787664
78EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10310489
79VDR_22108803_ChIP-Seq_LS180_Human1.08203821
80* TP53_18474530_ChIP-ChIP_U2OS_Human1.08192220
81* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.07777926
82PRDM14_20953172_ChIP-Seq_ESCs_Human1.07475825
83CDX2_22108803_ChIP-Seq_LS180_Human1.07436825
84CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07407689
85P53_22387025_ChIP-Seq_ESCs_Mouse1.06730184
86RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06242675
87TP63_23658742_ChIP-Seq_EP156T_Human1.06016211
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05679919
89CTCF_18555785_Chip-Seq_ESCs_Mouse1.05044657
90CRX_20693478_ChIP-Seq_RETINA_Mouse1.04727191
91NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04059448
92OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03995693
93ZFX_18555785_Chip-Seq_ESCs_Mouse1.03240952
94SMRT_27268052_Chip-Seq_Bcells_Human1.03018003
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01956443
96ESRRB_18555785_Chip-Seq_ESCs_Mouse1.01760679
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01548301
98GATA1_26923725_Chip-Seq_HPCs_Mouse1.01102355
99MYB_21317192_ChIP-Seq_ERMYB_Mouse0.99139789
100P300_18555785_Chip-Seq_ESCs_Mouse0.98306241
101CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97988286
102ESR1_21235772_ChIP-Seq_MCF-7_Human0.97863246
103SOX2_20726797_ChIP-Seq_SW620_Human0.97850074
104PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97708141
105KDM2B_26808549_Chip-Seq_REH_Human0.97060722
106GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96286401
107STAT1_20625510_ChIP-Seq_HELA_Human0.95865578
108AR_25329375_ChIP-Seq_VCAP_Human0.94490309
109FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.93932060
110SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.93797432
111PIAS1_25552417_ChIP-Seq_VCAP_Human0.93528109
112SMAD4_21799915_ChIP-Seq_A2780_Human0.93506706
113SMAD1_18555785_Chip-Seq_ESCs_Mouse0.92855163
114PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92774386
115RNF2_27304074_Chip-Seq_NSC_Mouse0.92435447
116PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92225328
117STAT3_23295773_ChIP-Seq_U87_Human0.90971922
118FUS_26573619_Chip-Seq_HEK293_Human0.90477353
119* EGR1_23403033_ChIP-Seq_LIVER_Mouse0.90239506
120SPI1_23127762_ChIP-Seq_K562_Human0.89592930
121ZNF217_24962896_ChIP-Seq_MCF-7_Human0.89109991
122ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87726972
123TAL1_26923725_Chip-Seq_HPCs_Mouse0.87586303
124GATA2_21666600_ChIP-Seq_HMVEC_Human0.87139386
125LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.86859044
126ER_23166858_ChIP-Seq_MCF-7_Human0.86746884
127PU1_27457419_Chip-Seq_LIVER_Mouse0.86158857
128STAT4_19710469_ChIP-ChIP_TH1__Mouse0.86081201
129JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86070655
130LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85538328
131RUNX1_27457419_Chip-Seq_LIVER_Mouse0.84938607
132GATA3_26560356_Chip-Seq_TH2_Human0.84741919
133JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84462947
134FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.84157941
135TP63_19390658_ChIP-ChIP_HaCaT_Human0.84114044
136MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.84007847
137P300_19829295_ChIP-Seq_ESCs_Human0.83908809

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation6.15672118
2MP0002254_reproductive_system_inflammat5.28083545
3MP0001346_abnormal_lacrimal_gland4.70990143
4MP0004510_myositis3.83942514
5MP0005451_abnormal_body_composition3.75653293
6MP0008004_abnormal_stomach_pH3.71536465
7MP0000685_abnormal_immune_system3.46521882
8MP0002139_abnormal_hepatobiliary_system3.46187953
9MP0001835_abnormal_antigen_presentation3.35913093
10MP0005310_abnormal_salivary_gland3.23803573
11MP0002138_abnormal_hepatobiliary_system3.06188456
12MP0002102_abnormal_ear_morphology2.65217839
13MP0003195_calcinosis2.60898528
14MP0009785_altered_susceptibility_to2.57681874
15MP0003300_gastrointestinal_ulcer2.57570997
16MP0005387_immune_system_phenotype2.57460221
17MP0001790_abnormal_immune_system2.57460221
18MP0002277_abnormal_respiratory_mucosa2.50950831
19MP0003724_increased_susceptibility_to2.41917753
20MP0003718_maternal_effect2.37115848
21MP0003646_muscle_fatigue2.20460705
22MP0005671_abnormal_response_to2.15326139
23MP0002332_abnormal_exercise_endurance1.95444689
24MP0002148_abnormal_hypersensitivity_rea1.93746383
25MP0003453_abnormal_keratinocyte_physiol1.89203873
26MP0009840_abnormal_foam_cell1.88395821
27MP0000579_abnormal_nail_morphology1.86278329
28MP0002876_abnormal_thyroid_physiology1.78063266
29MP0006082_CNS_inflammation1.76656607
30MP0001348_abnormal_lacrimal_gland1.69924323
31MP0003075_altered_response_to1.69777038
32MP0005058_abnormal_lysosome_morphology1.69223838
33MP0001501_abnormal_sleep_pattern1.67533727
34MP0006054_spinal_hemorrhage1.61193513
35MP0000566_synostosis1.59035334
36MP0005025_abnormal_response_to1.58044413
37MP0003436_decreased_susceptibility_to1.56270564
38MP0005000_abnormal_immune_tolerance1.53548767
39MP0003693_abnormal_embryo_hatching1.51452290
40MP0008469_abnormal_protein_level1.50666815
41MP0001853_heart_inflammation1.50217349
42MP0002419_abnormal_innate_immunity1.49722236
43MP0002452_abnormal_antigen_presenting1.49239909
44MP0002163_abnormal_gland_morphology1.48982818
45MP0008007_abnormal_cellular_replicative1.47674741
46MP0001800_abnormal_humoral_immune1.47189795
47MP0005167_abnormal_blood-brain_barrier1.46020876
48MP0001119_abnormal_female_reproductive1.45383671
49MP0003656_abnormal_erythrocyte_physiolo1.39264958
50MP0002723_abnormal_immune_serum1.37405705
51MP0002006_tumorigenesis1.37025320
52MP0002735_abnormal_chemical_nociception1.34575078
53MP0004782_abnormal_surfactant_physiolog1.33413301
54MP0005166_decreased_susceptibility_to1.30626704
55MP0000427_abnormal_hair_cycle1.29693071
56MP0003868_abnormal_feces_composition1.28410418
57MP0000516_abnormal_urinary_system1.27100626
58MP0005367_renal/urinary_system_phenotyp1.27100626
59MP0005535_abnormal_body_temperature1.25464586
60MP0001819_abnormal_immune_cell1.23636126
61MP0002098_abnormal_vibrissa_morphology1.23219846
62MP0002877_abnormal_melanocyte_morpholog1.23204314
63MP0005395_other_phenotype1.22958818
64MP0000613_abnormal_salivary_gland1.22574743
65MP0000383_abnormal_hair_follicle1.21526599
66MP0010094_abnormal_chromosome_stability1.21461788
67MP0009764_decreased_sensitivity_to1.20860987
68MP0004264_abnormal_extraembryonic_tissu1.19965415
69MP0002420_abnormal_adaptive_immunity1.19814659
70MP0003763_abnormal_thymus_physiology1.19442720
71MP0000858_altered_metastatic_potential1.18364540
72MP0004947_skin_inflammation1.17268359
73MP0002405_respiratory_system_inflammati1.15118100
74MP0005165_increased_susceptibility_to1.14575500
75MP0000627_abnormal_mammary_gland1.14530569
76MP0005408_hypopigmentation1.14477185
77MP0010155_abnormal_intestine_physiology1.14447734
78MP0000538_abnormal_urinary_bladder1.13100979
79MP0003699_abnormal_female_reproductive1.11910086
80MP0005397_hematopoietic_system_phenotyp1.10919303
81MP0001545_abnormal_hematopoietic_system1.10919303
82MP0001986_abnormal_taste_sensitivity1.09968075
83MP0009763_increased_sensitivity_to1.07762510
84MP0001845_abnormal_inflammatory_respons1.07595186
85MP0001663_abnormal_digestive_system1.06793063
86MP0002249_abnormal_larynx_morphology1.04030914
87MP0001851_eye_inflammation1.01353358
88MP0005647_abnormal_sex_gland1.01312786
89MP0010386_abnormal_urinary_bladder1.01050638
90MP0002998_abnormal_bone_remodeling0.99596297
91MP0003690_abnormal_glial_cell0.98703572
92* MP0000716_abnormal_immune_system0.98375423
93MP0005164_abnormal_response_to0.97517014
94MP0000604_amyloidosis0.97319183
95MP0002693_abnormal_pancreas_physiology0.96920728
96MP0009278_abnormal_bone_marrow0.95648361
97MP0001542_abnormal_bone_strength0.95128422
98MP0003091_abnormal_cell_migration0.94255299
99MP0009250_abnormal_appendicular_skeleto0.94034365
100MP0003448_altered_tumor_morphology0.92519714
101MP0000678_abnormal_parathyroid_gland0.92110603
102MP0003937_abnormal_limbs/digits/tail_de0.91889638
103MP0002398_abnormal_bone_marrow0.90896117
104MP0001533_abnormal_skeleton_physiology0.90540462
105MP0009333_abnormal_splenocyte_physiolog0.89444613
106MP0005379_endocrine/exocrine_gland_phen0.89165496
107MP0000733_abnormal_muscle_development0.88878356
108MP0003077_abnormal_cell_cycle0.88109775
109MP0006292_abnormal_olfactory_placode0.87788915
110MP0003806_abnormal_nucleotide_metabolis0.84511524
111MP0003172_abnormal_lysosome_physiology0.83575964
112MP0005390_skeleton_phenotype0.83429990
113MP0002177_abnormal_outer_ear0.82518925
114MP0001919_abnormal_reproductive_system0.81563333
115MP0005448_abnormal_energy_balance0.80634074
116MP0004185_abnormal_adipocyte_glucose0.80536758
117MP0001216_abnormal_epidermal_layer0.80384589
118MP0002396_abnormal_hematopoietic_system0.79935972
119MP0005023_abnormal_wound_healing0.79731209
120MP0001849_ear_inflammation0.79601080
121MP0009765_abnormal_xenobiotic_induced0.79596614
122MP0003705_abnormal_hypodermis_morpholog0.79423643
123MP0003045_fibrosis0.79370760
124MP0004043_abnormal_pH_regulation0.79257046
125MP0010678_abnormal_skin_adnexa0.78781719
126MP0003941_abnormal_skin_development0.78563688
127MP0001881_abnormal_mammary_gland0.77190898
128MP0003950_abnormal_plasma_membrane0.76836850
129MP0008874_decreased_physiological_sensi0.76815290
130MP0001873_stomach_inflammation0.75114631
131MP0003866_abnormal_defecation0.74795368
132MP0000569_abnormal_digit_pigmentation0.73897287
133MP0003183_abnormal_peptide_metabolism0.72486504
134MP0003566_abnormal_cell_adhesion0.71447888
135* MP0000689_abnormal_spleen_morphology0.70407765
136MP0002837_dystrophic_cardiac_calcinosis0.69778922
137MP0005365_abnormal_bile_salt0.69574432
138MP0001764_abnormal_homeostasis0.68799083
139MP0005266_abnormal_metabolism0.68214122
140MP0000343_altered_response_to0.68188652
141* MP0002429_abnormal_blood_cell0.67779049
142MP0000465_gastrointestinal_hemorrhage0.66453828
143MP0000609_abnormal_liver_physiology0.65954200
144MP0000249_abnormal_blood_vessel0.65140093
145MP0008789_abnormal_olfactory_epithelium0.64779938
146MP0005464_abnormal_platelet_physiology0.64683747
147MP0005381_digestive/alimentary_phenotyp0.64295347
148MP0002136_abnormal_kidney_physiology0.62858470
149MP0005666_abnormal_adipose_tissue0.62815102
150MP0002095_abnormal_skin_pigmentation0.62545679
151MP0003191_abnormal_cellular_cholesterol0.61605908

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)4.79167391
2Abnormality of liposaccharide metabolism (HP:0010968)4.79167391
3Abnormality of glycosphingolipid metabolism (HP:0004343)4.79167391
4Lip pit (HP:0100267)4.65217733
5Stomatitis (HP:0010280)4.17159711
6Retrobulbar optic neuritis (HP:0100654)4.07238530
7Optic neuritis (HP:0100653)4.07238530
8Prostate neoplasm (HP:0100787)3.96761958
9Abnormal respiratory motile cilium morphology (HP:0005938)3.90042479
10Abnormal respiratory epithelium morphology (HP:0012253)3.90042479
11Vacuolated lymphocytes (HP:0001922)3.79628723
12Eczematoid dermatitis (HP:0000976)3.76460844
13Systemic lupus erythematosus (HP:0002725)3.70713973
14Orchitis (HP:0100796)3.69473156
15Abnormality of the fingertips (HP:0001211)3.63652196
16Recurrent abscess formation (HP:0002722)3.57128095
17Loss of speech (HP:0002371)3.50677103
18Chronic sinusitis (HP:0011109)3.42844930
19Autoimmune thrombocytopenia (HP:0001973)3.38731142
20Recurrent bacterial skin infections (HP:0005406)3.37251929
21Myositis (HP:0100614)3.35876155
22Chromsome breakage (HP:0040012)3.35532457
23Disinhibition (HP:0000734)3.27641343
24Tetraparesis (HP:0002273)3.26888978
25Recurrent sinusitis (HP:0011108)3.15390992
26Male infertility (HP:0003251)3.06225132
27Chromosomal breakage induced by crosslinking agents (HP:0003221)3.05960817
28Absent/shortened dynein arms (HP:0200106)3.05297067
29Dynein arm defect of respiratory motile cilia (HP:0012255)3.05297067
30Dysostosis multiplex (HP:0000943)3.05091782
31Petechiae (HP:0000967)2.98792689
32Natal tooth (HP:0000695)2.91563374
33Anhidrosis (HP:0000970)2.91474722
34Adrenal hypoplasia (HP:0000835)2.88789884
35Milia (HP:0001056)2.86013983
36Nasolacrimal duct obstruction (HP:0000579)2.81000407
37Recurrent cutaneous fungal infections (HP:0011370)2.80980359
38Chronic mucocutaneous candidiasis (HP:0002728)2.80980359
39Purpura (HP:0000979)2.79767510
40Papillary thyroid carcinoma (HP:0002895)2.79339321
41Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.77915580
42Increased IgM level (HP:0003496)2.76822719
43Joint swelling (HP:0001386)2.76683749
44Increased cerebral lipofuscin (HP:0011813)2.76013746
45Mutism (HP:0002300)2.75658289
46Nuclear cataract (HP:0100018)2.71161600
47Periodontitis (HP:0000704)2.68466496
48Glomerulonephritis (HP:0000099)2.67273044
49Vertebral compression fractures (HP:0002953)2.66253410
50Gangrene (HP:0100758)2.63806188
51Hematochezia (HP:0002573)2.62515633
52Keratoconjunctivitis (HP:0001096)2.61012533
53Acute myeloid leukemia (HP:0004808)2.59359675
54Inappropriate behavior (HP:0000719)2.57935165
55Abnormal delayed hypersensitivity skin test (HP:0002963)2.56902074
56Recurrent skin infections (HP:0001581)2.55662214
57Vasculitis (HP:0002633)2.55609361
58Flat capital femoral epiphysis (HP:0003370)2.52015188
59Onycholysis (HP:0001806)2.51000958
60Abnormality of polysaccharide metabolism (HP:0011012)2.47707669
61Abnormality of glycosaminoglycan metabolism (HP:0004371)2.47707669
62Abnormality of mucopolysaccharide metabolism (HP:0011020)2.47707669
63Arterial thrombosis (HP:0004420)2.47252478
64Spontaneous abortion (HP:0005268)2.44925410
65Recurrent gram-negative bacterial infections (HP:0005420)2.44764215
66Aplasia cutis congenita (HP:0001057)2.39673832
67Microretrognathia (HP:0000308)2.37858094
68Increased serum ferritin (HP:0003281)2.37564064
69Chronic otitis media (HP:0000389)2.36702106
70Mixed hearing impairment (HP:0000410)2.36123246
71Urinary glycosaminoglycan excretion (HP:0003541)2.35876011
72Mucopolysacchariduria (HP:0008155)2.35876011
73Gastrointestinal stroma tumor (HP:0100723)2.34414507
74Encephalitis (HP:0002383)2.33725456
75Alveolar cell carcinoma (HP:0006519)2.31548104
76Plantar hyperkeratosis (HP:0007556)2.31528959
77Type 2 muscle fiber atrophy (HP:0003554)2.30401819
78Mediastinal lymphadenopathy (HP:0100721)2.29674984
79Recurrent bronchitis (HP:0002837)2.29461818
80Premature loss of primary teeth (HP:0006323)2.29430420
81Prolonged bleeding time (HP:0003010)2.27914381
82Increased neuronal autofluorescent lipopigment (HP:0002074)2.27305124
83IgA deficiency (HP:0002720)2.26671590
84Metaphyseal irregularity (HP:0003025)2.26556867
85Thoracolumbar scoliosis (HP:0002944)2.24724566
86Neoplasm of the tracheobronchial system (HP:0100552)2.23883917
87Periauricular skin pits (HP:0100277)2.23652038
88Preauricular pit (HP:0004467)2.23652038
89Capillary hemangiomas (HP:0005306)2.23012972
90Recurrent fungal infections (HP:0002841)2.21539130
91Polyneuropathy (HP:0001271)2.21241768
92Keratoconjunctivitis sicca (HP:0001097)2.21184282
93Hypergammaglobulinemia (HP:0010702)2.18826341
94Abnormality of the lacrimal duct (HP:0011481)2.18548867
95Abnormal ciliary motility (HP:0012262)2.18485323
96Congenital sensorineural hearing impairment (HP:0008527)2.18277195
97Protruding tongue (HP:0010808)2.17200152
98Abnormality of the prostate (HP:0008775)2.16464221
99Interstitial pulmonary disease (HP:0006530)2.16076890
100Clubbing of toes (HP:0100760)2.15856641
101Abnormality of iron homeostasis (HP:0011031)2.14840061
102Intrahepatic cholestasis (HP:0001406)2.12471768
103Atrophic scars (HP:0001075)2.12189237
104Gastrointestinal infarctions (HP:0005244)2.11433777
105Nausea (HP:0002018)2.11077099
106Autoimmune hemolytic anemia (HP:0001890)2.10213091
107Abnormality of the neuromuscular junction (HP:0003398)2.09820401
108Fatigable weakness (HP:0003473)2.09820401
109Pulmonary infiltrates (HP:0002113)2.08166553
110Hypergonadotropic hypogonadism (HP:0000815)2.08082032
111Abnormality of B cell number (HP:0010975)2.07996929
112Abnormality of macrophages (HP:0004311)2.06186585
113Colitis (HP:0002583)2.05976167
114Muscle fiber atrophy (HP:0100295)2.05920781
115Patellar aplasia (HP:0006443)2.05279987
116Ventricular fibrillation (HP:0001663)2.03411131
117Arterial tortuosity (HP:0005116)2.02296343
118Bronchiectasis (HP:0002110)2.01176134
119Abnormality of transition element cation homeostasis (HP:0011030)1.98000471
120Albinism (HP:0001022)1.97997601
121Shawl scrotum (HP:0000049)1.96196939
122Abnormal respiratory motile cilium physiology (HP:0012261)1.95058666
123Pustule (HP:0200039)1.94921315
124Acne (HP:0001061)1.94734894
125Abnormality of incisor morphology (HP:0011063)1.93268547
126Progressive neurologic deterioration (HP:0002344)1.92789605
127Keratitis (HP:0000491)1.92653226
128Cortical dysplasia (HP:0002539)1.92593326
129Hemoptysis (HP:0002105)1.91410514
130Absent hand (HP:0004050)1.90385634
131Thrombocytosis (HP:0001894)1.90228429
132Abnormality of male internal genitalia (HP:0000022)1.90061334
133Abnormality of the vasculature of the conjunctiva (HP:0008054)1.89738755
134Chronic diarrhea (HP:0002028)1.89389599
135Xerostomia (HP:0000217)1.89002962
136Elevated erythrocyte sedimentation rate (HP:0003565)1.88716458
137Hyperventilation (HP:0002883)1.88425522
138Hypoplasia of dental enamel (HP:0006297)1.87955278
139Aplasia/Hypoplasia of the patella (HP:0006498)1.87829399
140Abnormality of the preputium (HP:0100587)1.86846268
141Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.86335955
142Pulmonary fibrosis (HP:0002206)1.86274104
143Complement deficiency (HP:0004431)1.85794737
144Generalized aminoaciduria (HP:0002909)1.85545370
145Abnormality of the nasal mucosa (HP:0000433)1.84815088
146Cleft eyelid (HP:0000625)1.83227550
147Recurrent viral infections (HP:0004429)1.82032656
148Abnormality of the labia minora (HP:0012880)1.81494303
149Abnormality of the pleura (HP:0002103)1.79286795
150Emphysema (HP:0002097)1.78791004
151Basal ganglia calcification (HP:0002135)1.78609992
152Nail dystrophy (HP:0008404)1.78470100
153Thick nail (HP:0001805)1.78391951
154Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.78079476
155Arthralgia (HP:0002829)1.77050425
156Tetany (HP:0001281)1.75776217
157Malnutrition (HP:0004395)1.75158987
158Dry hair (HP:0011359)1.74989615
159Abnormality of the pericardium (HP:0001697)1.74690488
160Abnormality of T cell number (HP:0011839)1.74545503
161Esophageal varix (HP:0002040)1.74150058
162Recurrent pneumonia (HP:0006532)1.73427764
163Aseptic necrosis (HP:0010885)1.72652374
164Insulin-resistant diabetes mellitus (HP:0000831)1.72480689
165Aplasia/Hypoplasia of the uvula (HP:0010293)1.71659711
166Vascular tortuosity (HP:0004948)1.70700849
167Parakeratosis (HP:0001036)1.69375896
168Weak cry (HP:0001612)1.69243209
169Fibular aplasia (HP:0002990)1.68093621
170Skin pits (HP:0100276)1.68076726
171Pili torti (HP:0003777)1.67692490
172Nasal polyposis (HP:0100582)1.66083819
173Abnormality of the gastric mucosa (HP:0004295)1.63703145
174Recurrent lower respiratory tract infections (HP:0002783)1.63534277
175Porencephaly (HP:0002132)1.62204584
176Facial hemangioma (HP:0000329)1.62186673

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.21546307
2LATS13.86890736
3MAP3K133.49318162
4GRK73.21436819
5MAP3K142.90012565
6STK38L2.85842426
7TAOK32.72963740
8ERBB42.71190418
9MUSK2.66000613
10PLK42.65544750
11IKBKE2.62186193
12MAP3K62.60826944
13JAK32.53960954
14LATS22.52248266
15ARAF2.32786667
16BMPR22.32031186
17TYK22.26936385
18DDR22.26556263
19KSR22.12223205
20MAPKAPK32.11886761
21FRK2.08489074
22BRAF2.04112367
23IKBKB2.03240998
24MOS2.01225556
25STK32.00642160
26CHUK1.94869677
27TAOK21.87997029
28RAF11.84176868
29NME21.82683158
30NUAK11.81838394
31RPS6KA41.76488870
32TBK11.76035889
33RIPK41.75234120
34IRAK11.74497976
35EEF2K1.71375112
36MAP4K11.67809821
37KIT1.51814749
38RIPK11.50129831
39INSRR1.48964274
40CDK81.48167625
41TRPM71.47436569
42MAP3K91.46377781
43NLK1.45464241
44TAOK11.35850274
45BMPR1B1.33242316
46TTK1.31920963
47IRAK21.29796474
48MST41.28687308
49ADRBK21.23715687
50MAP2K61.23012106
51CDC42BPA1.14636205
52JAK11.11390674
53IRAK41.08180767
54LYN1.05806362
55TGFBR21.04076580
56ABL21.01169146
57SYK1.01044122
58CHEK20.98713736
59MAP3K110.98200655
60MELK0.97932986
61STK100.96424111
62RPS6KB20.95673910
63CSK0.94262726
64MAP2K30.92605965
65CDK90.89940441
66CSF1R0.89739841
67PRKAA20.89558455
68TNIK0.89272034
69MAP3K120.88803423
70MAPKAPK50.88028079
71PKN10.87760131
72LMTK20.87410063
73STK240.85519751
74MAP3K30.83438340
75TEC0.81713342
76DAPK20.77912277
77EPHA30.76261083
78PIM10.75553163
79EIF2AK20.75115975
80DYRK30.74293963
81ZAP700.73717754
82DMPK0.71750826
83VRK10.71664440
84CDK120.71101054
85ZAK0.70432220
86PRPF4B0.67879025
87PAK60.67776578
88DYRK20.66147000
89MAP3K10.65082265
90JAK20.63902274
91IRAK30.62449970
92CDK30.59255548
93MARK30.58701006
94BMX0.56480355
95KSR10.55422238
96MAP3K50.53538016
97BLK0.52498895
98ABL10.52138553
99STK40.50978217
100CAMKK20.50424001
101MAP3K80.49347177
102MAPK130.48744020
103PRKCQ0.47822430
104PIM20.46298092
105BCR0.45210224
106PDGFRA0.43040490
107PRKG20.42601326
108MAPK70.41261381
109PBK0.40648997
110PRKAA10.40135644
111PLK10.38903159
112NME10.38427696
113EGFR0.37433404
114MAPK40.36816747
115CDK40.36587437
116MAP4K20.36145898
117PINK10.35847215
118NEK90.35520383
119MAPK150.35396486
120ERBB30.35244508
121NEK20.34951937
122EPHB10.34601290
123MAPK110.33401195
124PLK20.33049140
125TLK10.32850894
126EPHA20.32187940
127PLK30.31776410
128CDK60.31751897
129MAPKAPK20.31718476
130RPS6KA50.31026074
131TXK0.30866326
132CLK10.29995335
133PTK2B0.29577864
134PDGFRB0.29335949
135PRKCE0.28592126
136FGR0.27931782
137HCK0.27890971
138AURKB0.27315591
139MATK0.26958347
140ACVR1B0.26785401
141ERN10.26508648
142MAP3K40.26327733
143BTK0.26315306
144STK390.25214793
145ICK0.25043970
146ATM0.23668791
147EPHB20.22130843
148PRKD20.21942564
149HIPK20.21462328
150MAP2K10.20015583
151SIK30.17160458
152LCK0.16077978

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.83678761
2Leishmaniasis_Homo sapiens_hsa051402.49613783
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.46178725
4Allograft rejection_Homo sapiens_hsa053302.44472507
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.35489728
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.26829956
7Graft-versus-host disease_Homo sapiens_hsa053322.25896212
8NOD-like receptor signaling pathway_Homo sapiens_hsa046212.21145277
9RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.20311958
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.16619131
11Influenza A_Homo sapiens_hsa051642.10362779
12Herpes simplex infection_Homo sapiens_hsa051682.03579334
13Measles_Homo sapiens_hsa051622.03399486
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.97164614
15TNF signaling pathway_Homo sapiens_hsa046681.86862966
16* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.76473527
17p53 signaling pathway_Homo sapiens_hsa041151.72442487
18Rheumatoid arthritis_Homo sapiens_hsa053231.71104598
19Prolactin signaling pathway_Homo sapiens_hsa049171.65090199
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.64844243
21Ovarian steroidogenesis_Homo sapiens_hsa049131.63547032
22Toxoplasmosis_Homo sapiens_hsa051451.61226530
23Osteoclast differentiation_Homo sapiens_hsa043801.56079151
24Ether lipid metabolism_Homo sapiens_hsa005651.54084651
25Malaria_Homo sapiens_hsa051441.53782385
26Basal transcription factors_Homo sapiens_hsa030221.50732325
27Autoimmune thyroid disease_Homo sapiens_hsa053201.49525516
28Pancreatic cancer_Homo sapiens_hsa052121.48153543
29Lysosome_Homo sapiens_hsa041421.46997061
30* Jak-STAT signaling pathway_Homo sapiens_hsa046301.46433778
31Sulfur metabolism_Homo sapiens_hsa009201.45586372
32Cell cycle_Homo sapiens_hsa041101.45348701
33Linoleic acid metabolism_Homo sapiens_hsa005911.42968976
34Chemokine signaling pathway_Homo sapiens_hsa040621.35403530
35TGF-beta signaling pathway_Homo sapiens_hsa043501.32947565
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.32305418
37Legionellosis_Homo sapiens_hsa051341.31147635
38Pertussis_Homo sapiens_hsa051331.28589976
39RNA degradation_Homo sapiens_hsa030181.25471638
40Type I diabetes mellitus_Homo sapiens_hsa049401.25059113
41Tuberculosis_Homo sapiens_hsa051521.23031739
42Circadian rhythm_Homo sapiens_hsa047101.21192536
43Shigellosis_Homo sapiens_hsa051311.21065645
44Hepatitis B_Homo sapiens_hsa051611.20310192
45Apoptosis_Homo sapiens_hsa042101.16033952
46Small cell lung cancer_Homo sapiens_hsa052221.10930747
47Glycosaminoglycan degradation_Homo sapiens_hsa005311.10060708
48African trypanosomiasis_Homo sapiens_hsa051431.07613034
49Salmonella infection_Homo sapiens_hsa051321.05627063
50Antigen processing and presentation_Homo sapiens_hsa046120.98431740
51Staphylococcus aureus infection_Homo sapiens_hsa051500.97213275
52Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.95709577
53Hepatitis C_Homo sapiens_hsa051600.95413588
54Arachidonic acid metabolism_Homo sapiens_hsa005900.91474297
55Fanconi anemia pathway_Homo sapiens_hsa034600.90516393
56Dorso-ventral axis formation_Homo sapiens_hsa043200.87623001
57MicroRNAs in cancer_Homo sapiens_hsa052060.85966821
58Primary immunodeficiency_Homo sapiens_hsa053400.85851394
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.85670791
60Type II diabetes mellitus_Homo sapiens_hsa049300.83278365
61Tryptophan metabolism_Homo sapiens_hsa003800.82938273
62Amoebiasis_Homo sapiens_hsa051460.82864403
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81039700
64ABC transporters_Homo sapiens_hsa020100.80654031
65Vitamin B6 metabolism_Homo sapiens_hsa007500.79087648
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.79042386
67Complement and coagulation cascades_Homo sapiens_hsa046100.78148245
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76783351
69Folate biosynthesis_Homo sapiens_hsa007900.76158557
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.75693369
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73488701
72Notch signaling pathway_Homo sapiens_hsa043300.73194553
73Adherens junction_Homo sapiens_hsa045200.72767514
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72704680
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71164873
76Homologous recombination_Homo sapiens_hsa034400.71040849
77Epstein-Barr virus infection_Homo sapiens_hsa051690.70705070
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68731124
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68430087
80T cell receptor signaling pathway_Homo sapiens_hsa046600.67873010
81* Hematopoietic cell lineage_Homo sapiens_hsa046400.67239406
82B cell receptor signaling pathway_Homo sapiens_hsa046620.64180632
83Choline metabolism in cancer_Homo sapiens_hsa052310.63810951
84Prion diseases_Homo sapiens_hsa050200.63049306
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61815409
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59783268
87Mineral absorption_Homo sapiens_hsa049780.59484706
88Phagosome_Homo sapiens_hsa041450.58966560
89FoxO signaling pathway_Homo sapiens_hsa040680.56947592
90HTLV-I infection_Homo sapiens_hsa051660.55734000
91Thyroid cancer_Homo sapiens_hsa052160.54457361
92Viral myocarditis_Homo sapiens_hsa054160.54151158
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53644407
94Ras signaling pathway_Homo sapiens_hsa040140.51172255
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50955629
96Collecting duct acid secretion_Homo sapiens_hsa049660.50599116
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50462700
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49706447
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46208170
100ECM-receptor interaction_Homo sapiens_hsa045120.46124867
101Chronic myeloid leukemia_Homo sapiens_hsa052200.43898608
102Other glycan degradation_Homo sapiens_hsa005110.43344360
103Renin-angiotensin system_Homo sapiens_hsa046140.43117638
104Starch and sucrose metabolism_Homo sapiens_hsa005000.42467916
105GnRH signaling pathway_Homo sapiens_hsa049120.41394754
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41310629
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41112543
108Acute myeloid leukemia_Homo sapiens_hsa052210.41048301
109Chemical carcinogenesis_Homo sapiens_hsa052040.40408629
110Hippo signaling pathway_Homo sapiens_hsa043900.40217008
111Pathways in cancer_Homo sapiens_hsa052000.39368578
112Steroid hormone biosynthesis_Homo sapiens_hsa001400.38570350
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38280217
114MAPK signaling pathway_Homo sapiens_hsa040100.37831325
115VEGF signaling pathway_Homo sapiens_hsa043700.37247707
116Fatty acid biosynthesis_Homo sapiens_hsa000610.36957966
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34712321
118Viral carcinogenesis_Homo sapiens_hsa052030.33482937
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.33384279
120Prostate cancer_Homo sapiens_hsa052150.31687821
121Renal cell carcinoma_Homo sapiens_hsa052110.31244269
122Colorectal cancer_Homo sapiens_hsa052100.30570343
123Melanoma_Homo sapiens_hsa052180.29047304
124Sphingolipid metabolism_Homo sapiens_hsa006000.27830875
125Platelet activation_Homo sapiens_hsa046110.27683769
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27315413
127PPAR signaling pathway_Homo sapiens_hsa033200.25656573
128Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25025498
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24747669
130Systemic lupus erythematosus_Homo sapiens_hsa053220.23587945
131Insulin resistance_Homo sapiens_hsa049310.22639009
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.22025987
133Caffeine metabolism_Homo sapiens_hsa002320.21295029
134Serotonergic synapse_Homo sapiens_hsa047260.20029377
135Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.19817441

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