IL6R

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)5.78720168
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.78720168
3positive regulation of gamma-delta T cell activation (GO:0046645)5.70826499
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.62261337
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.52578961
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.52578961
7modulation by symbiont of host immune response (GO:0052553)5.52578961
8positive regulation by symbiont of host defense response (GO:0052509)5.52578961
9modulation by symbiont of host defense response (GO:0052031)5.52578961
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.52578961
11neutrophil activation involved in immune response (GO:0002283)4.96798753
12macrophage activation involved in immune response (GO:0002281)4.91145204
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.86384865
14response to peptidoglycan (GO:0032494)4.85451040
15detection of other organism (GO:0098543)4.83240839
16antigen processing and presentation of endogenous antigen (GO:0019883)4.77852218
17detection of molecule of bacterial origin (GO:0032490)4.68830117
18cellular extravasation (GO:0045123)4.57747601
19detection of bacterium (GO:0016045)4.47543533
20negative regulation of interleukin-12 production (GO:0032695)4.45998174
21regulation of B cell receptor signaling pathway (GO:0050855)4.44186787
22antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.39472266
23detection of external biotic stimulus (GO:0098581)4.38959875
24regulation of gamma-delta T cell activation (GO:0046643)4.22577416
25regulation of interferon-beta biosynthetic process (GO:0045357)4.13232092
26positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.09673573
27microglial cell activation (GO:0001774)3.99992613
28leukocyte aggregation (GO:0070486)3.96171956
29negative regulation of lymphocyte mediated immunity (GO:0002707)3.94499845
30positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.93793806
31neutrophil activation (GO:0042119)3.93086103
32detection of biotic stimulus (GO:0009595)3.88525940
33macrophage activation (GO:0042116)3.78192963
34respiratory burst (GO:0045730)3.76156848
35regulation of gamma-delta T cell differentiation (GO:0045586)3.74931747
36response to host immune response (GO:0052572)3.70820064
37response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.70820064
38immunoglobulin mediated immune response (GO:0016064)3.68638247
39granulocyte activation (GO:0036230)3.66962804
40myeloid cell activation involved in immune response (GO:0002275)3.61194837
41negative regulation of T cell mediated immunity (GO:0002710)3.54526733
42response to interleukin-15 (GO:0070672)3.53991043
43negative regulation of leukocyte mediated immunity (GO:0002704)3.51340571
44regulation of mast cell degranulation (GO:0043304)3.48122625
45positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.48093190
46response to host (GO:0075136)3.39392511
47response to host defenses (GO:0052200)3.39392511
48response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.39392511
49leukocyte migration involved in inflammatory response (GO:0002523)3.35741617
50regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.34959479
51response to muramyl dipeptide (GO:0032495)3.33374710
52regulation of myeloid leukocyte mediated immunity (GO:0002886)3.28066377
53positive regulation of mast cell activation (GO:0033005)3.24154582
54production of molecular mediator involved in inflammatory response (GO:0002532)3.23525744
55lipopolysaccharide-mediated signaling pathway (GO:0031663)3.22969447
56antigen processing and presentation via MHC class Ib (GO:0002475)3.22018054
57germinal center formation (GO:0002467)3.21373906
58negative thymic T cell selection (GO:0045060)3.21097414
59regulation of mast cell activation involved in immune response (GO:0033006)3.20351537
60defense response to protozoan (GO:0042832)3.19540691
61type I interferon signaling pathway (GO:0060337)3.19497839
62cellular response to type I interferon (GO:0071357)3.19497839
63regulation of tolerance induction (GO:0002643)3.17610434
64response to type I interferon (GO:0034340)3.17580382
65* neutrophil mediated immunity (GO:0002446)3.16996290
66regulation of T cell tolerance induction (GO:0002664)3.15848339
67regulation of leukocyte degranulation (GO:0043300)3.15746301
68B cell receptor signaling pathway (GO:0050853)3.14694804
69cellular response to interleukin-15 (GO:0071350)3.13453334
70negative T cell selection (GO:0043383)3.13104056
71regulation of mast cell activation (GO:0033003)3.10725369
72negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.07777539
73regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.07467067
74positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.07440829
75regulation of B cell differentiation (GO:0045577)3.06917398
76positive regulation of B cell differentiation (GO:0045579)3.06146555
77interferon-gamma-mediated signaling pathway (GO:0060333)3.06003772
78T cell migration (GO:0072678)3.04524762
79positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.03207209
80negative regulation of erythrocyte differentiation (GO:0045647)3.02836277
81dendritic cell migration (GO:0036336)2.98142471
82dendritic cell chemotaxis (GO:0002407)2.94697698
83negative regulation of interleukin-6 production (GO:0032715)2.94027354
84regulation of dendritic cell antigen processing and presentation (GO:0002604)2.93970374
85leukocyte degranulation (GO:0043299)2.93421072
86positive regulation of interferon-alpha production (GO:0032727)2.92977242
87positive regulation of cellular amide metabolic process (GO:0034250)2.91628254
88response to protozoan (GO:0001562)2.90658623
89negative regulation of cytokine production involved in immune response (GO:0002719)2.87063971
90positive thymic T cell selection (GO:0045059)2.85283486
91regulation of T-helper 2 cell differentiation (GO:0045628)2.85269747
92regulation of interferon-alpha production (GO:0032647)2.84138982
93myeloid leukocyte activation (GO:0002274)2.83466164
94B cell mediated immunity (GO:0019724)2.82707956
95tolerance induction (GO:0002507)2.81410323
96regulation of alpha-beta T cell proliferation (GO:0046640)2.80604605
97regulation of T cell mediated cytotoxicity (GO:0001914)2.80286903
98positive regulation of mast cell activation involved in immune response (GO:0033008)2.79055820
99positive regulation of mast cell degranulation (GO:0043306)2.79055820
100regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.78667742

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.58106071
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.70366485
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.09183167
4* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.90256283
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.73096489
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.62853604
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.43241784
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.36250171
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.98319632
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.86168297
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.84738227
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.79670764
13* RUNX_20019798_ChIP-Seq_JUKART_Human2.75681667
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.64684502
15* VDR_24763502_ChIP-Seq_THP-1_Human2.54184000
16* SPI1_23547873_ChIP-Seq_NB4_Human2.53000408
17VDR_21846776_ChIP-Seq_THP-1_Human2.50038563
18SPI1_23127762_ChIP-Seq_K562_Human2.44260467
19SCL_19346495_ChIP-Seq_HPC-7_Human2.38142626
20Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.31476008
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.28706940
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.28418137
23MYB_26560356_Chip-Seq_TH2_Human2.27392128
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.22843040
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.22516881
26BRD4_27068464_Chip-Seq_AML-cells_Mouse2.20716552
27* MAF_26560356_Chip-Seq_TH1_Human2.14575936
28STAT4_19710469_ChIP-ChIP_TH1__Mouse2.14229222
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.13332030
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.11165834
31RUNX1_22412390_ChIP-Seq_EML_Mouse2.07122152
32RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.03363898
33VDR_24787735_ChIP-Seq_THP-1_Human1.99054468
34* MYB_26560356_Chip-Seq_TH1_Human1.93341639
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.93122986
36* UTX_26944678_Chip-Seq_JUKART_Human1.85492239
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.82504513
38MYC_22102868_ChIP-Seq_BL_Human1.77592538
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.76353053
40TCF7_22412390_ChIP-Seq_EML_Mouse1.74448858
41* GATA3_27048872_Chip-Seq_THYMUS_Human1.63619653
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.63064867
43* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.62241474
44LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.59093218
45CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.54834312
46GATA1_19941827_ChIP-Seq_MEL_Mouse1.53166442
47* MAF_26560356_Chip-Seq_TH2_Human1.50764559
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.49805399
49STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.49477912
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.46710487
51GATA1_22025678_ChIP-Seq_K562_Human1.46169415
52PU_27001747_Chip-Seq_BMDM_Mouse1.45069314
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.44798619
54PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.41709324
55KDM2B_26808549_Chip-Seq_DND41_Human1.39970414
56* GATA3_26560356_Chip-Seq_TH2_Human1.38422619
57* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.37094238
58KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.36327670
59GATA2_22383799_ChIP-Seq_G1ME_Mouse1.35990195
60PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34939062
61CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25703454
62GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.25316082
63PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24499632
64GATA1_19941826_ChIP-Seq_K562_Human1.24333801
65THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22964571
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22864853
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22228944
68CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21765975
69PPARA_22158963_ChIP-Seq_LIVER_Mouse1.21172491
70CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20552672
71* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18050381
72PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16861491
73GATA1_22383799_ChIP-Seq_G1ME_Mouse1.16291034
74GATA2_21666600_ChIP-Seq_HMVEC_Human1.15425321
75RXR_22158963_ChIP-Seq_LIVER_Mouse1.13462848
76SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11440343
77STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09817880
78SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09067393
79FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.08790040
80* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08775827
81LXR_22158963_ChIP-Seq_LIVER_Mouse1.07883127
82ELK3_25401928_ChIP-Seq_HUVEC_Human1.05556125
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02861816
84GATA2_19941826_ChIP-Seq_K562_Human1.02641841
85NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02512510
86PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99015883
87ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.97576706
88* LXR_22292898_ChIP-Seq_THP-1_Human0.96522019
89VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96470609
90* KDM2B_26808549_Chip-Seq_JURKAT_Human0.95610261
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95056485
92SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.94094685
93BCL6_27268052_Chip-Seq_Bcells_Human0.86287627
94STAT6_21828071_ChIP-Seq_BEAS2B_Human0.85225001
95BCOR_27268052_Chip-Seq_Bcells_Human0.83212043
96EGR1_23403033_ChIP-Seq_LIVER_Mouse0.83164025
97TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82849493
98* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.79593584
99NCOR1_26117541_ChIP-Seq_K562_Human0.79566423
100GATA1_19941827_ChIP-Seq_MEL86_Mouse0.79314636

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.59591097
2MP0003303_peritoneal_inflammation4.10153557
3MP0003436_decreased_susceptibility_to3.95210436
4MP0001835_abnormal_antigen_presentation3.58766351
5MP0002419_abnormal_innate_immunity3.03240933
6MP0009785_altered_susceptibility_to2.84475892
7MP0005671_abnormal_response_to2.80664404
8MP0006082_CNS_inflammation2.79932467
9MP0005025_abnormal_response_to2.77044049
10MP0001800_abnormal_humoral_immune2.73477035
11MP0005000_abnormal_immune_tolerance2.71711381
12MP0000685_abnormal_immune_system2.68571801
13MP0005387_immune_system_phenotype2.61372042
14MP0001790_abnormal_immune_system2.61372042
15MP0002723_abnormal_immune_serum2.46108218
16MP0002148_abnormal_hypersensitivity_rea2.43681128
17MP0002452_abnormal_antigen_presenting2.39324715
18MP0003300_gastrointestinal_ulcer2.39120472
19MP0002420_abnormal_adaptive_immunity2.32688293
20MP0001819_abnormal_immune_cell2.30732621
21MP0003191_abnormal_cellular_cholesterol2.30306792
22MP0005451_abnormal_body_composition2.12730688
23MP0005464_abnormal_platelet_physiology2.08024270
24MP0003172_abnormal_lysosome_physiology2.06934673
25MP0003763_abnormal_thymus_physiology2.03986229
26MP0001533_abnormal_skeleton_physiology2.03781534
27MP0002405_respiratory_system_inflammati1.92092646
28MP0008260_abnormal_autophagy1.86510376
29MP0001845_abnormal_inflammatory_respons1.81261101
30MP0010155_abnormal_intestine_physiology1.80471360
31MP0003828_pulmonary_edema1.76408183
32MP0000716_abnormal_immune_system1.75736207
33MP0004947_skin_inflammation1.72125407
34MP0002398_abnormal_bone_marrow1.71067527
35MP0009333_abnormal_splenocyte_physiolog1.68790300
36MP0009764_decreased_sensitivity_to1.67175262
37MP0005058_abnormal_lysosome_morphology1.63296378
38MP0008469_abnormal_protein_level1.56984469
39MP0002132_abnormal_respiratory_system1.55414419
40MP0000689_abnormal_spleen_morphology1.49563786
41MP0000465_gastrointestinal_hemorrhage1.48427534
42MP0003075_altered_response_to1.45148718
43MP0002722_abnormal_immune_system1.44215029
44MP0009278_abnormal_bone_marrow1.44171629
45MP0004883_abnormal_blood_vessel1.40952422
46MP0003866_abnormal_defecation1.36562473
47MP0002429_abnormal_blood_cell1.36379060
48MP0005310_abnormal_salivary_gland1.33632722
49MP0003690_abnormal_glial_cell1.32107975
50MP0000858_altered_metastatic_potential1.32061812
51MP0004381_abnormal_hair_follicle1.31454313
52MP0002998_abnormal_bone_remodeling1.30674970
53MP0005397_hematopoietic_system_phenotyp1.29935843
54MP0001545_abnormal_hematopoietic_system1.29935843
55MP0002396_abnormal_hematopoietic_system1.27034906
56MP0004510_myositis1.26492882
57MP0003656_abnormal_erythrocyte_physiolo1.23807754
58MP0001851_eye_inflammation1.22914819
59MP0005164_abnormal_response_to1.21808897
60MP0003183_abnormal_peptide_metabolism1.21231701
61MP0009840_abnormal_foam_cell1.19876236
62MP0000703_abnormal_thymus_morphology1.19494822
63MP0002139_abnormal_hepatobiliary_system1.19352368
64MP0002277_abnormal_respiratory_mucosa1.16785013
65MP0000604_amyloidosis1.14647782
66MP0005166_decreased_susceptibility_to1.13778443
67MP0002166_altered_tumor_susceptibility1.10475694
68MP0002138_abnormal_hepatobiliary_system1.08392547
69MP0000343_altered_response_to1.03226968
70MP0001853_heart_inflammation0.95198323
71MP0008004_abnormal_stomach_pH0.94508349
72MP0009763_increased_sensitivity_to0.92935847
73MP0003448_altered_tumor_morphology0.89468771
74MP0001663_abnormal_digestive_system0.88006590
75MP0001873_stomach_inflammation0.81795379
76MP0005085_abnormal_gallbladder_physiolo0.80977957
77MP0003806_abnormal_nucleotide_metabolis0.80922039
78MP0000569_abnormal_digit_pigmentation0.80605687
79MP0004808_abnormal_hematopoietic_stem0.77775699
80MP0005075_abnormal_melanosome_morpholog0.75774320
81MP0002006_tumorigenesis0.75748107
82MP0003195_calcinosis0.75171951
83MP0005365_abnormal_bile_salt0.74526579
84MP0005390_skeleton_phenotype0.74277570
85MP0003252_abnormal_bile_duct0.72555511
86MP0003045_fibrosis0.72293980
87MP0000015_abnormal_ear_pigmentation0.72196050
88MP0000609_abnormal_liver_physiology0.71723487
89MP0002332_abnormal_exercise_endurance0.71549254
90MP0000249_abnormal_blood_vessel0.70373923
91MP0009765_abnormal_xenobiotic_induced0.69966247
92MP0004130_abnormal_muscle_cell0.69147348
93MP0002933_joint_inflammation0.68585389
94MP0005167_abnormal_blood-brain_barrier0.67474627
95MP0005319_abnormal_enzyme/_coenzyme0.66891099
96MP0003221_abnormal_cardiomyocyte_apopto0.66223880
97MP0008874_decreased_physiological_sensi0.65268655
98MP0003795_abnormal_bone_structure0.63104582
99MP0003091_abnormal_cell_migration0.62792709
100MP0005376_homeostasis/metabolism_phenot0.58442588

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.29189987
2Recurrent bacterial skin infections (HP:0005406)5.71691842
3Recurrent abscess formation (HP:0002722)5.68374298
4Myositis (HP:0100614)5.62357074
5Orchitis (HP:0100796)5.42631362
6Retrobulbar optic neuritis (HP:0100654)5.19481631
7Optic neuritis (HP:0100653)5.19481631
8Abnormality of macrophages (HP:0004311)5.18657835
9Recurrent gram-negative bacterial infections (HP:0005420)5.13517487
10Stomatitis (HP:0010280)4.74796784
11Elevated erythrocyte sedimentation rate (HP:0003565)4.47965013
12Mediastinal lymphadenopathy (HP:0100721)3.99972386
13Gastrointestinal infarctions (HP:0005244)3.99372153
14Recurrent fungal infections (HP:0002841)3.97733611
15Recurrent skin infections (HP:0001581)3.84707464
16Keratoconjunctivitis sicca (HP:0001097)3.81076385
17Chronic obstructive pulmonary disease (HP:0006510)3.66648376
18Obstructive lung disease (HP:0006536)3.66648376
19Meningitis (HP:0001287)3.65730395
20Keratoconjunctivitis (HP:0001096)3.56109548
21Abnormal delayed hypersensitivity skin test (HP:0002963)3.53239314
22Encephalitis (HP:0002383)3.48062529
23Spontaneous hematomas (HP:0007420)3.41155434
24Chronic mucocutaneous candidiasis (HP:0002728)3.41152205
25Recurrent cutaneous fungal infections (HP:0011370)3.41152205
26Gingivitis (HP:0000230)3.39783976
27Vasculitis (HP:0002633)3.36163684
28Gingival bleeding (HP:0000225)3.25910323
29Urticaria (HP:0001025)3.22157745
30Increased IgE level (HP:0003212)3.17529549
31T lymphocytopenia (HP:0005403)3.10380728
32Pulmonary infiltrates (HP:0002113)3.06613733
33Amyloidosis (HP:0011034)3.05526530
34Hemoptysis (HP:0002105)3.04249782
35Abnormality of T cell number (HP:0011839)2.97867402
36Prolonged bleeding time (HP:0003010)2.92322394
37Arterial thrombosis (HP:0004420)2.91206317
38Chest pain (HP:0100749)2.90766123
39Episodic fever (HP:0001954)2.86855757
40Hypochromic microcytic anemia (HP:0004840)2.85502768
41Increased cerebral lipofuscin (HP:0011813)2.83473100
42Pulmonary embolism (HP:0002204)2.83160623
43Abnormality of glycolipid metabolism (HP:0010969)2.80972650
44Abnormality of liposaccharide metabolism (HP:0010968)2.80972650
45Abnormality of glycosphingolipid metabolism (HP:0004343)2.80972650
46Epistaxis (HP:0000421)2.78369940
47Leukocytosis (HP:0001974)2.76891143
48Pustule (HP:0200039)2.71490275
49Recurrent viral infections (HP:0004429)2.70555554
50Anorexia (HP:0002039)2.68295019
51Gangrene (HP:0100758)2.67972266
52Cellulitis (HP:0100658)2.66696069
53Hypochromic anemia (HP:0001931)2.65909160
54Peritonitis (HP:0002586)2.65544488
55Systemic lupus erythematosus (HP:0002725)2.59175128
56Inflammation of the large intestine (HP:0002037)2.52538244
57Abnormality of T cells (HP:0002843)2.52224432
58Loss of speech (HP:0002371)2.49217723
59Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.46723193
60Gastrointestinal inflammation (HP:0004386)2.40634475
61Increased neuronal autofluorescent lipopigment (HP:0002074)2.40285120
62Granulocytopenia (HP:0001913)2.35195199
63Abnormality of the pleura (HP:0002103)2.28432645
64Purpura (HP:0000979)2.27104726
65Increased IgM level (HP:0003496)2.24595861
66Osteomyelitis (HP:0002754)2.21817192
67Petechiae (HP:0000967)2.21689214
68Vacuolated lymphocytes (HP:0001922)2.21666644
69Increased serum ferritin (HP:0003281)2.20521385
70Autoimmune thrombocytopenia (HP:0001973)2.20331733
71Dysostosis multiplex (HP:0000943)2.19385909
72Colitis (HP:0002583)2.16343124
73Abnormality of T cell physiology (HP:0011840)2.13641799
74Microcytic anemia (HP:0001935)2.13345391
75Panhypogammaglobulinemia (HP:0003139)2.13228533
76Abnormality of iron homeostasis (HP:0011031)2.09260579
77Hypergammaglobulinemia (HP:0010702)2.09132514
78Abnormality of the peritoneum (HP:0002585)2.05647046
79Glomerulopathy (HP:0100820)2.05391901
80Eosinophilia (HP:0001880)2.04488974
81Abnormality of the endocardium (HP:0004306)2.04095497
82Polyneuropathy (HP:0001271)2.03837738
83Joint swelling (HP:0001386)2.03245892
84Sepsis (HP:0100806)2.03200740
85Acne (HP:0001061)2.02918901
86Autoimmune hemolytic anemia (HP:0001890)2.02819424
87Thrombophlebitis (HP:0004418)2.01551091
88Slow saccadic eye movements (HP:0000514)2.00208183
89Vertigo (HP:0002321)1.99463430
90Acute hepatic failure (HP:0006554)1.95361724
91Lymphopenia (HP:0001888)1.92120939
92Keratitis (HP:0000491)1.91324088
93Hematochezia (HP:0002573)1.88451109
94Skin ulcer (HP:0200042)1.87343468
95Disinhibition (HP:0000734)1.87142968
96Abnormality of the pericardium (HP:0001697)1.83930485
97Abnormality of glycosaminoglycan metabolism (HP:0004371)1.83469639
98Abnormality of mucopolysaccharide metabolism (HP:0011020)1.83469639
99Abnormality of polysaccharide metabolism (HP:0011012)1.83469639
100Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.82719584

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.30513435
2MAP4K13.40485674
3BLK2.99624958
4TYK22.91303316
5MAP2K32.88191783
6ERN12.84103850
7IRAK42.81915672
8PRPF4B2.59909643
9CSK2.55594713
10FES2.31015512
11ZAP702.12204117
12MAP3K142.11863980
13GRK62.08171838
14TXK1.94841898
15TAOK31.85043744
16TNK21.84970071
17JAK31.83739647
18EPHB11.76443126
19MAP3K31.75641149
20FGR1.75464684
21TAOK11.74190568
22IKBKE1.71582557
23BTK1.66452854
24SYK1.63872282
25HCK1.63515571
26MAP3K131.61103922
27TBK11.58013159
28JAK11.48545029
29JAK21.43409354
30MAP3K111.42616834
31MAP3K11.36292468
32LYN1.34338514
33CSF1R1.31228637
34MATK1.24775257
35IRAK31.23502457
36ITK1.23356306
37IRAK11.19912172
38LCK1.17469426
39YES11.17222981
40KIT1.16641873
41KSR21.15200528
42PIK3CG1.10451101
43IKBKB1.10154908
44TAOK21.07768345
45TGFBR21.05476223
46BMPR21.04066905
47MARK31.03291077
48TEC0.97002835
49IRAK20.95951186
50PDK10.94609194
51STK100.93079730
52MARK20.92208109
53MAP3K20.90269382
54GRK70.88861359
55SIK30.86960317
56FGFR30.83870476
57MAP3K60.83020108
58PDPK10.81056770
59NLK0.70307899
60PTK60.68272539
61MAPK120.68127986
62PRKD20.66771599
63MAP3K50.66504060
64SGK30.65314169
65CDC42BPA0.64968857
66LRRK20.64476326
67EPHA30.64334144
68MAPK70.64044221
69FGFR40.63704600
70MAP2K60.63342568
71TRIB30.61278071
72PIM10.58947231
73MAP3K70.57848868
74ACVR1B0.56644952
75MAP2K40.56585794
76DYRK1B0.56201410
77CAMKK20.55260153
78FYN0.55189223
79HIPK20.55109158
80SGK20.55057744
81PRKCQ0.54722596
82DAPK20.51151697
83RPS6KC10.49025053
84RPS6KL10.49025053
85PTK2B0.48226331
86SIK20.48201265
87STK110.47337546
88CDK190.46348287
89RPS6KA60.43128085
90MOS0.40595079
91RET0.39618289
92CDK60.38234379
93RAF10.37684993
94CHUK0.36099242
95RIPK10.35463046
96MAPKAPK20.33936543
97TESK20.33794502
98CAMKK10.33583366
99STK380.32547183
100STK240.32254343

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.21308152
2Leishmaniasis_Homo sapiens_hsa051403.05422654
3Osteoclast differentiation_Homo sapiens_hsa043802.98396893
4Graft-versus-host disease_Homo sapiens_hsa053322.36895313
5Allograft rejection_Homo sapiens_hsa053302.36460646
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.23072229
7Tuberculosis_Homo sapiens_hsa051522.20111991
8B cell receptor signaling pathway_Homo sapiens_hsa046622.13370189
9Autoimmune thyroid disease_Homo sapiens_hsa053202.11103068
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.08591609
11NOD-like receptor signaling pathway_Homo sapiens_hsa046212.04315881
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.98043952
13Malaria_Homo sapiens_hsa051441.92167346
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.83300531
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.80699799
16Type I diabetes mellitus_Homo sapiens_hsa049401.79937362
17Primary immunodeficiency_Homo sapiens_hsa053401.77509162
18Measles_Homo sapiens_hsa051621.75278305
19Other glycan degradation_Homo sapiens_hsa005111.71912791
20Legionellosis_Homo sapiens_hsa051341.67414324
21Acute myeloid leukemia_Homo sapiens_hsa052211.63314808
22T cell receptor signaling pathway_Homo sapiens_hsa046601.62187775
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.61904327
24Chemokine signaling pathway_Homo sapiens_hsa040621.57932901
25Toxoplasmosis_Homo sapiens_hsa051451.57852856
26Influenza A_Homo sapiens_hsa051641.55951142
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.54981934
28* Hematopoietic cell lineage_Homo sapiens_hsa046401.51799257
29Antigen processing and presentation_Homo sapiens_hsa046121.51149819
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.49971220
31TNF signaling pathway_Homo sapiens_hsa046681.44315314
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.42294991
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.38731269
34Pertussis_Homo sapiens_hsa051331.38291618
35Asthma_Homo sapiens_hsa053101.34337157
36* Jak-STAT signaling pathway_Homo sapiens_hsa046301.33033990
37Phagosome_Homo sapiens_hsa041451.32651515
38Viral myocarditis_Homo sapiens_hsa054161.32208225
39African trypanosomiasis_Homo sapiens_hsa051431.30561690
40Herpes simplex infection_Homo sapiens_hsa051681.24140940
41Rheumatoid arthritis_Homo sapiens_hsa053231.21944971
42Complement and coagulation cascades_Homo sapiens_hsa046101.20016609
43Lysosome_Homo sapiens_hsa041421.12468292
44Hepatitis C_Homo sapiens_hsa051601.10012703
45Hepatitis B_Homo sapiens_hsa051611.09681661
46Non-small cell lung cancer_Homo sapiens_hsa052231.06530325
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.04923208
48Platelet activation_Homo sapiens_hsa046111.04583757
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.02923333
50Salmonella infection_Homo sapiens_hsa051320.94892229
51Glycosaminoglycan degradation_Homo sapiens_hsa005310.94479719
52* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92889160
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88192821
54Apoptosis_Homo sapiens_hsa042100.87803905
55Prolactin signaling pathway_Homo sapiens_hsa049170.85183675
56Pancreatic cancer_Homo sapiens_hsa052120.84298548
57VEGF signaling pathway_Homo sapiens_hsa043700.83991110
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.80450883
59Chronic myeloid leukemia_Homo sapiens_hsa052200.79373914
60Shigellosis_Homo sapiens_hsa051310.78494902
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78298071
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74643294
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73579921
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.70074791
65FoxO signaling pathway_Homo sapiens_hsa040680.68320065
66Renal cell carcinoma_Homo sapiens_hsa052110.67601849
67Amoebiasis_Homo sapiens_hsa051460.66642265
68Dorso-ventral axis formation_Homo sapiens_hsa043200.66124991
69Insulin resistance_Homo sapiens_hsa049310.65479537
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64269776
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.64134173
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60165267
73Endocytosis_Homo sapiens_hsa041440.54255437
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53936235
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51809395
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.50977323
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50598998
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.50276529
79Type II diabetes mellitus_Homo sapiens_hsa049300.48663563
80Epstein-Barr virus infection_Homo sapiens_hsa051690.48334435
81GnRH signaling pathway_Homo sapiens_hsa049120.48257794
82mTOR signaling pathway_Homo sapiens_hsa041500.46807563
83Notch signaling pathway_Homo sapiens_hsa043300.46193627
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44881961
85Inositol phosphate metabolism_Homo sapiens_hsa005620.44199104
86Endometrial cancer_Homo sapiens_hsa052130.44010642
87Choline metabolism in cancer_Homo sapiens_hsa052310.43734992
88Viral carcinogenesis_Homo sapiens_hsa052030.42896097
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42281915
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.38830082
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38342932
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35929030
93Arachidonic acid metabolism_Homo sapiens_hsa005900.35135072
94* HIF-1 signaling pathway_Homo sapiens_hsa040660.33985766
95HTLV-I infection_Homo sapiens_hsa051660.33386074
96Prion diseases_Homo sapiens_hsa050200.31809491
97MAPK signaling pathway_Homo sapiens_hsa040100.31590481
98Prostate cancer_Homo sapiens_hsa052150.27610694
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27244165
100Insulin signaling pathway_Homo sapiens_hsa049100.25895088

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