IL27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of vitamin D biosynthetic process (GO:0060556)6.72624411
2modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.91999029
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.91999029
4positive regulation by organism of defense response of other organism involved in symbiotic interact5.91999029
5modulation by symbiont of host immune response (GO:0052553)5.91999029
6positive regulation by symbiont of host defense response (GO:0052509)5.91999029
7modulation by symbiont of host defense response (GO:0052031)5.91999029
8positive regulation of interferon-alpha production (GO:0032727)5.89160340
9regulation of interferon-alpha production (GO:0032647)5.68680174
10regulation of cytokine secretion involved in immune response (GO:0002739)5.50553817
11regulation of vitamin metabolic process (GO:0030656)5.34227787
12cellular response to type I interferon (GO:0071357)5.14486133
13type I interferon signaling pathway (GO:0060337)5.14486133
14response to peptidoglycan (GO:0032494)5.13164900
15response to type I interferon (GO:0034340)5.08613878
16negative regulation of interleukin-12 production (GO:0032695)5.06984897
17neutrophil activation involved in immune response (GO:0002283)5.05511414
18negative regulation of viral genome replication (GO:0045071)4.99869328
19response to interferon-alpha (GO:0035455)4.96009157
20branching involved in labyrinthine layer morphogenesis (GO:0060670)4.90471601
21cellular response to interferon-alpha (GO:0035457)4.67893234
22lipopolysaccharide-mediated signaling pathway (GO:0031663)4.67218933
23cellular response to exogenous dsRNA (GO:0071360)4.65624141
24immunoglobulin mediated immune response (GO:0016064)4.53793295
25cellular response to interferon-beta (GO:0035458)4.43885471
26positive regulation of type 2 immune response (GO:0002830)4.41327082
27positive regulation of chemokine biosynthetic process (GO:0045080)4.31543280
28response to host immune response (GO:0052572)4.30297397
29response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.30297397
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.26474915
31positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.25113406
32eosinophil chemotaxis (GO:0048245)4.20583656
33granulocyte activation (GO:0036230)4.14080716
34response to interferon-beta (GO:0035456)4.12625253
35T cell migration (GO:0072678)4.05732101
36positive regulation of interferon-beta production (GO:0032728)4.05072484
37T-helper 1 type immune response (GO:0042088)4.03622388
38positive regulation of natural killer cell differentiation (GO:0032825)3.98952710
39positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.98084841
40regulation of mononuclear cell migration (GO:0071675)3.96003838
41negative regulation of cytokine production involved in immune response (GO:0002719)3.95037104
42* regulation of T-helper 1 cell differentiation (GO:0045625)3.91765606
43positive regulation of heat generation (GO:0031652)3.90637159
44lymphocyte chemotaxis (GO:0048247)3.89238234
45regulation of heat generation (GO:0031650)3.86685444
46macrophage activation involved in immune response (GO:0002281)3.86412546
47response to protozoan (GO:0001562)3.83330271
48negative regulation of nitric oxide biosynthetic process (GO:0045019)3.82687602
49cellular response to virus (GO:0098586)3.82164221
50regulation of fever generation (GO:0031620)3.81485583
51negative regulation of amino acid transport (GO:0051956)3.81001404
52regulation of chronic inflammatory response (GO:0002676)3.80486668
53regulation of nitric oxide biosynthetic process (GO:0045428)3.79641425
54regulation of interferon-beta biosynthetic process (GO:0045357)3.79568392
55positive regulation of nitric oxide biosynthetic process (GO:0045429)3.79260486
56response to host (GO:0075136)3.78870320
57response to host defenses (GO:0052200)3.78870320
58response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.78870320
59positive regulation of T cell cytokine production (GO:0002726)3.77951104
60negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.76999297
61regulation of membrane protein ectodomain proteolysis (GO:0051043)3.75504004
62eosinophil migration (GO:0072677)3.74330223
63natural killer cell mediated immunity (GO:0002228)3.71457247
64natural killer cell mediated cytotoxicity (GO:0042267)3.71457247
65regulation of chemokine biosynthetic process (GO:0045073)3.68864965
66interferon-gamma-mediated signaling pathway (GO:0060333)3.66651357
67positive regulation of lymphocyte migration (GO:2000403)3.66231506
68NIK/NF-kappaB signaling (GO:0038061)3.64828084
69positive regulation of interleukin-12 production (GO:0032735)3.64680031
70hydrogen peroxide biosynthetic process (GO:0050665)3.63616249
71respiratory burst (GO:0045730)3.62245476
72positive regulation of cAMP-mediated signaling (GO:0043950)3.61962388
73positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.60307487
74germinal center formation (GO:0002467)3.59931993
75positive regulation of interleukin-17 production (GO:0032740)3.58785060
76regulation of immunoglobulin secretion (GO:0051023)3.58616099
77myeloid dendritic cell differentiation (GO:0043011)3.57840673
78regulation of interleukin-12 production (GO:0032655)3.57399829
79neutrophil activation (GO:0042119)3.53851207
80positive regulation of NF-kappaB import into nucleus (GO:0042346)3.53586601
81regulation of activation of Janus kinase activity (GO:0010533)3.52276057
82regulation of RIG-I signaling pathway (GO:0039535)3.49560032
83positive regulation of acute inflammatory response (GO:0002675)3.48860560
84response to muramyl dipeptide (GO:0032495)3.48665612
85regulation of heterotypic cell-cell adhesion (GO:0034114)3.48221027
86defense response to protozoan (GO:0042832)3.46772330
87regulation of type I interferon-mediated signaling pathway (GO:0060338)3.45235214
88modulation of growth of symbiont involved in interaction with host (GO:0044144)3.44193669
89regulation of growth of symbiont in host (GO:0044126)3.44193669
90negative regulation of growth of symbiont in host (GO:0044130)3.44193669
91negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.44193669
92antigen processing and presentation of endogenous antigen (GO:0019883)3.44020654
93monocyte chemotaxis (GO:0002548)3.41693982
94positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.41180692
95B cell mediated immunity (GO:0019724)3.39261829
96activation of MAPKKK activity (GO:0000185)3.37544833
97positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.37260652
98regulation of type 2 immune response (GO:0002828)3.36851950
99regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.36541724
100regulation of dendritic cell antigen processing and presentation (GO:0002604)3.36534109
101positive regulation of defense response to virus by host (GO:0002230)3.35940393
102cellular response to lipopolysaccharide (GO:0071222)3.35019260
103positive regulation of humoral immune response (GO:0002922)3.33866905
104microglial cell activation (GO:0001774)3.31908192
105positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.31703308
106production of molecular mediator involved in inflammatory response (GO:0002532)3.31587146
107negative regulation of myeloid cell apoptotic process (GO:0033033)3.30742335
108regulation of podosome assembly (GO:0071801)3.30534644
109regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.29745848
110positive regulation of toll-like receptor signaling pathway (GO:0034123)3.29471961
111regulation of interleukin-8 biosynthetic process (GO:0045414)3.28993511
112antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.27472434
113antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.27472434
114myeloid cell activation involved in immune response (GO:0002275)3.26542894
115regulation of NF-kappaB import into nucleus (GO:0042345)3.26527230
116regulation of lymphocyte chemotaxis (GO:1901623)3.26437403
117positive regulation of T-helper cell differentiation (GO:0045624)3.25527186
118cellular response to molecule of bacterial origin (GO:0071219)3.24001143
119negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.23084627
120positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.21301764
121reactive oxygen species biosynthetic process (GO:1903409)3.20785640
122negative regulation of production of molecular mediator of immune response (GO:0002701)3.20318800
123cellular response to nicotine (GO:0071316)3.19923260
124myeloid dendritic cell activation (GO:0001773)3.19348598
125positive regulation of mast cell activation (GO:0033005)3.18519766
126regulation of T-helper 2 cell differentiation (GO:0045628)3.18276213
127positive regulation of gamma-delta T cell activation (GO:0046645)3.18031825
128dendritic cell differentiation (GO:0097028)3.17870983
129positive regulation of antigen processing and presentation (GO:0002579)3.17775021
130negative regulation of viral process (GO:0048525)3.16577853
131superoxide anion generation (GO:0042554)3.16373567
132regulation of interleukin-17 production (GO:0032660)3.15661113
133positive regulation of immunoglobulin mediated immune response (GO:0002891)3.15555289
134positive regulation of B cell mediated immunity (GO:0002714)3.15555289
135positive regulation of interleukin-6 production (GO:0032755)3.15292006
136regulation of inflammatory response to antigenic stimulus (GO:0002861)3.15255313
137defense response to virus (GO:0051607)3.14811220
138cellular response to interferon-gamma (GO:0071346)3.14419547
139regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.12959788
140positive regulation of cellular amide metabolic process (GO:0034250)3.12628543
141positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.12169278
142regulation of antigen processing and presentation (GO:0002577)3.10332946
143positive regulation of mast cell activation involved in immune response (GO:0033008)3.08257083
144positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.07546185
145positive regulation of lymphocyte apoptotic process (GO:0070230)3.03506756
146negative regulation of lipid storage (GO:0010888)3.03256048
147interferon-gamma secretion (GO:0072643)3.02854731
148virion attachment to host cell (GO:0019062)3.00297057
149adhesion of symbiont to host cell (GO:0044650)3.00297057
150JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.90878811
151negative regulation of type I interferon production (GO:0032480)2.90169674
152positive regulation of natural killer cell activation (GO:0032816)2.86687727
153response to interferon-gamma (GO:0034341)2.85640673

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human8.51472227
2IRF8_21731497_ChIP-ChIP_J774_Mouse7.76660065
3BP1_19119308_ChIP-ChIP_Hs578T_Human7.35363133
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human6.26530565
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.42437636
6* IRF8_27001747_Chip-Seq_BMDM_Mouse4.38829271
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.73865673
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.73415689
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.56612512
10* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.45497290
11Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.03772672
12EGR1_19374776_ChIP-ChIP_THP-1_Human3.03437284
13STAT4_19710469_ChIP-ChIP_TH1__Mouse2.94362139
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.79399950
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.78299648
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.67569722
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.58507637
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.50138793
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.19074160
20GATA1_22025678_ChIP-Seq_K562_Human1.95858129
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.94382241
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.73735415
23* SPI1_23547873_ChIP-Seq_NB4_Human1.70308565
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.61776905
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.61073172
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.60444946
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.60134632
28PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.59649930
29VDR_24787735_ChIP-Seq_THP-1_Human1.55986029
30CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.54912654
31CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.52883371
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.51827132
33* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.50417723
34PU_27001747_Chip-Seq_BMDM_Mouse1.48796395
35MYB_26560356_Chip-Seq_TH2_Human1.42341138
36PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40542315
37KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.36754692
38KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.36754692
39KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.36754692
40FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.31762970
41VDR_24763502_ChIP-Seq_THP-1_Human1.28915862
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.26491617
43CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.26467199
44ESR1_21235772_ChIP-Seq_MCF-7_Human1.26435345
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25786723
46CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25327923
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.25137308
48MAF_26560356_Chip-Seq_TH1_Human1.23729536
49SPI1_23127762_ChIP-Seq_K562_Human1.23240412
50GATA3_26560356_Chip-Seq_TH2_Human1.20978114
51CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19943446
52RUNX1_22412390_ChIP-Seq_EML_Mouse1.18991555
53VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.18749541
54MYB_26560356_Chip-Seq_TH1_Human1.18655076
55SCL_19346495_ChIP-Seq_HPC-7_Human1.17484375
56RUNX_20019798_ChIP-Seq_JUKART_Human1.16464953
57PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16245240
58GATA2_21666600_ChIP-Seq_HMVEC_Human1.12759757
59STAT1_20625510_ChIP-Seq_HELA_Human1.07485208
60FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.06083402
61VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05806276
62EGR1_19032775_ChIP-ChIP_M12_Human1.03453550
63PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03214773
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01577861
65CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99773031
66GATA3_27048872_Chip-Seq_THYMUS_Human0.98617786
67KDM2B_26808549_Chip-Seq_DND41_Human0.96370866
68GATA1_19941826_ChIP-Seq_K562_Human0.95384513
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94284317
70LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.92722144
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92618982
72MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.92485480
73CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92137733
74RXR_22158963_ChIP-Seq_LIVER_Mouse0.91701254
75IKZF1_21737484_ChIP-ChIP_HCT116_Human0.90794632
76EGR1_23403033_ChIP-Seq_LIVER_Mouse0.90612271
77LXR_22292898_ChIP-Seq_THP-1_Human0.90194029
78SOX2_20726797_ChIP-Seq_SW620_Human0.90162696
79NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89618760
80TCF7_22412390_ChIP-Seq_EML_Mouse0.89134132
81SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88909945
82NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87371187
83NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87371187
84TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86498204
85* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.85932937
86TP63_17297297_ChIP-ChIP_HaCaT_Human0.85027114
87TRIM28_21343339_ChIP-Seq_HEK293_Human0.83391694
88RARG_19884340_ChIP-ChIP_MEFs_Mouse0.82944233
89STAT3_1855785_ChIP-Seq_MESCs_Mouse0.82435376
90KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.82179567
91GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.81250714
92LXR_22158963_ChIP-Seq_LIVER_Mouse0.81223997
93LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.79985750
94PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.78888498
95SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.74874350
96PPARA_22158963_ChIP-Seq_LIVER_Mouse0.72900381
97CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.71155078
98KDM2B_26808549_Chip-Seq_K562_Human0.70160990
99GATA1_19941827_ChIP-Seq_MEL86_Mouse0.67116334
100E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.64890045
101GATA1_19941827_ChIP-Seq_MEL_Mouse0.64654788
102VDR_21846776_ChIP-Seq_THP-1_Human0.63667316
103* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.61641290
104UTX_26944678_Chip-Seq_JUKART_Human0.61391207
105ELK3_25401928_ChIP-Seq_HUVEC_Human0.60845847
106MAF_26560356_Chip-Seq_TH2_Human0.59841779
107BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.59766329
108KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.59502888
109PU.1_20513432_ChIP-Seq_Bcells_Mouse0.59377245
110CJUN_26792858_Chip-Seq_BT549_Human0.57715561
111SMRT_27268052_Chip-Seq_Bcells_Human0.57622601
112GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.55005160
113TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.53987432
114JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.53491638
115JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.51330546
116GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.50009628
117SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.49087728
118SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.49087728
119ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.48084999
120SPI1_20517297_ChIP-Seq_HL60_Human0.48061290
121SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.47916122
122P63_26484246_Chip-Seq_KERATINOCYTES_Human0.46856283
123GATA2_19941826_ChIP-Seq_K562_Human0.44515357
124RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.44336380
125TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.43407338

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009785_altered_susceptibility_to4.67098452
2MP0001835_abnormal_antigen_presentation4.64272254
3MP0006082_CNS_inflammation4.50815977
4MP0003436_decreased_susceptibility_to4.20254590
5* MP0002148_abnormal_hypersensitivity_rea4.10145047
6MP0003303_peritoneal_inflammation3.78361230
7MP0003724_increased_susceptibility_to3.67751694
8* MP0005000_abnormal_immune_tolerance3.47721532
9MP0005025_abnormal_response_to3.29787682
10MP0000685_abnormal_immune_system3.29553252
11MP0005387_immune_system_phenotype3.25049862
12MP0001790_abnormal_immune_system3.25049862
13MP0002419_abnormal_innate_immunity3.09257414
14MP0005671_abnormal_response_to3.06000317
15MP0004510_myositis2.93681416
16MP0002723_abnormal_immune_serum2.64459577
17MP0002452_abnormal_antigen_presenting2.62394308
18MP0001800_abnormal_humoral_immune2.60797091
19MP0008004_abnormal_stomach_pH2.46281152
20MP0009764_decreased_sensitivity_to2.43418004
21MP0001533_abnormal_skeleton_physiology2.38669137
22MP0002139_abnormal_hepatobiliary_system2.37063944
23MP0001853_heart_inflammation2.36569245
24MP0005451_abnormal_body_composition2.35846809
25MP0001819_abnormal_immune_cell2.18023897
26MP0004947_skin_inflammation2.17379301
27MP0005058_abnormal_lysosome_morphology2.10424085
28MP0002420_abnormal_adaptive_immunity2.10202608
29MP0005464_abnormal_platelet_physiology1.90959676
30MP0001845_abnormal_inflammatory_respons1.88819444
31MP0008469_abnormal_protein_level1.88239702
32MP0002254_reproductive_system_inflammat1.82970577
33MP0006054_spinal_hemorrhage1.79350750
34MP0010155_abnormal_intestine_physiology1.78429339
35MP0003448_altered_tumor_morphology1.74854827
36MP0003075_altered_response_to1.74661375
37MP0009278_abnormal_bone_marrow1.68279259
38MP0005310_abnormal_salivary_gland1.68212301
39MP0000343_altered_response_to1.65189516
40MP0002405_respiratory_system_inflammati1.58724284
41MP0000716_abnormal_immune_system1.55027051
42MP0002006_tumorigenesis1.53621937
43MP0005397_hematopoietic_system_phenotyp1.49904838
44MP0001545_abnormal_hematopoietic_system1.49904838
45MP0009333_abnormal_splenocyte_physiolog1.46768832
46* MP0002398_abnormal_bone_marrow1.38705940
47MP0003806_abnormal_nucleotide_metabolis1.32688386
48MP0003186_abnormal_redox_activity1.26421796
49MP0000858_altered_metastatic_potential1.25964711
50MP0003172_abnormal_lysosome_physiology1.25957684
51MP0002998_abnormal_bone_remodeling1.24438754
52MP0009840_abnormal_foam_cell1.20117419
53MP0005164_abnormal_response_to1.19750993
54MP0002429_abnormal_blood_cell1.19674231
55MP0001542_abnormal_bone_strength1.19630258
56MP0004782_abnormal_surfactant_physiolog1.15691782
57MP0009763_increased_sensitivity_to1.13800503
58MP0000604_amyloidosis1.12267082
59MP0005167_abnormal_blood-brain_barrier1.11840609
60MP0005166_decreased_susceptibility_to1.11634695
61MP0003300_gastrointestinal_ulcer1.10457607
62MP0000689_abnormal_spleen_morphology1.09059214
63MP0003690_abnormal_glial_cell1.08990382
64MP0002277_abnormal_respiratory_mucosa1.08274694
65MP0005390_skeleton_phenotype1.08146489
66MP0004858_abnormal_nervous_system1.04799049
67MP0002722_abnormal_immune_system0.98347147
68MP0001501_abnormal_sleep_pattern0.95615269
69MP0003453_abnormal_keratinocyte_physiol0.91965984
70MP0010307_abnormal_tumor_latency0.86207040
71MP0005666_abnormal_adipose_tissue0.86178321
72MP0002166_altered_tumor_susceptibility0.84792159
73MP0001851_eye_inflammation0.83624687
74MP0005266_abnormal_metabolism0.83184041
75MP0003091_abnormal_cell_migration0.79407920
76MP0003195_calcinosis0.78916932
77MP0002332_abnormal_exercise_endurance0.75383792
78MP0002138_abnormal_hepatobiliary_system0.74804840
79MP0008874_decreased_physiological_sensi0.74113444
80MP0005647_abnormal_sex_gland0.72020626
81MP0004808_abnormal_hematopoietic_stem0.71917758
82MP0010352_gastrointestinal_tract_polyps0.71587282
83MP0001764_abnormal_homeostasis0.69668008
84MP0002933_joint_inflammation0.66280893
85MP0003191_abnormal_cellular_cholesterol0.63905870
86MP0003763_abnormal_thymus_physiology0.63596707
87MP0003646_muscle_fatigue0.61088565
88MP0000249_abnormal_blood_vessel0.59512471
89MP0008260_abnormal_autophagy0.59478471
90MP0010386_abnormal_urinary_bladder0.59470674
91MP0003828_pulmonary_edema0.57781912
92MP0002693_abnormal_pancreas_physiology0.56794714
93MP0005076_abnormal_cell_differentiation0.55505167
94MP0005165_increased_susceptibility_to0.55272531
95MP0002136_abnormal_kidney_physiology0.53632609
96MP0000920_abnormal_myelination0.53250722
97MP0009765_abnormal_xenobiotic_induced0.52597020
98MP0003866_abnormal_defecation0.52210727
99MP0000569_abnormal_digit_pigmentation0.52180865
100MP0005023_abnormal_wound_healing0.51216879
101MP0000490_abnormal_crypts_of0.51210847
102MP0005381_digestive/alimentary_phenotyp0.51141705
103MP0004883_abnormal_blood_vessel0.50978509
104MP0005376_homeostasis/metabolism_phenot0.50258983
105MP0005083_abnormal_biliary_tract0.49778109
106MP0001663_abnormal_digestive_system0.49518176
107MP0002163_abnormal_gland_morphology0.49510386
108MP0003183_abnormal_peptide_metabolism0.48534190
109MP0003941_abnormal_skin_development0.48404339
110MP0005319_abnormal_enzyme/_coenzyme0.48347623
111MP0000609_abnormal_liver_physiology0.47522092
112MP0001919_abnormal_reproductive_system0.47260914
113MP0005595_abnormal_vascular_smooth0.46872549
114MP0003795_abnormal_bone_structure0.45592629
115MP0008438_abnormal_cutaneous_collagen0.45563813
116MP0003045_fibrosis0.45291580
117MP0005535_abnormal_body_temperature0.45242546
118MP0002837_dystrophic_cardiac_calcinosis0.44944953
119MP0003656_abnormal_erythrocyte_physiolo0.44788855
120MP0001348_abnormal_lacrimal_gland0.44643010
121MP0002090_abnormal_vision0.44403469

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.77161266
2Eczematoid dermatitis (HP:0000976)6.73255792
3Recurrent bacterial skin infections (HP:0005406)6.36264728
4Elevated erythrocyte sedimentation rate (HP:0003565)6.05129046
5Recurrent gram-negative bacterial infections (HP:0005420)5.88790685
6Mediastinal lymphadenopathy (HP:0100721)5.53127457
7Increased IgM level (HP:0003496)5.51763627
8Systemic lupus erythematosus (HP:0002725)5.33530671
9Autoimmune thrombocytopenia (HP:0001973)5.19025511
10Abnormality of macrophages (HP:0004311)5.08980754
11Basal ganglia calcification (HP:0002135)4.71119557
12Myositis (HP:0100614)4.69542931
13Orchitis (HP:0100796)4.57091914
14Stomatitis (HP:0010280)4.52661904
15Optic neuritis (HP:0100653)4.45827929
16Retrobulbar optic neuritis (HP:0100654)4.45827929
17Vasculitis (HP:0002633)4.31417604
18Vacuolated lymphocytes (HP:0001922)3.93439099
19Nuclear cataract (HP:0100018)3.89206491
20Gingivitis (HP:0000230)3.72843954
21Increased neuronal autofluorescent lipopigment (HP:0002074)3.71089567
22Hypergammaglobulinemia (HP:0010702)3.69689519
23Recurrent skin infections (HP:0001581)3.68253915
24Increased cerebral lipofuscin (HP:0011813)3.61824451
25Interstitial pulmonary disease (HP:0006530)3.56331668
26Mutism (HP:0002300)3.55661521
27Obstructive lung disease (HP:0006536)3.50567557
28Chronic obstructive pulmonary disease (HP:0006510)3.50567557
29Porencephaly (HP:0002132)3.31429752
30Recurrent fungal infections (HP:0002841)3.29655114
31Recurrent viral infections (HP:0004429)3.19778498
32Poor head control (HP:0002421)3.18858780
33Chronic otitis media (HP:0000389)3.13259730
34Pulmonary infiltrates (HP:0002113)3.06465862
35Abnormality of mucopolysaccharide metabolism (HP:0011020)3.05480242
36Abnormality of polysaccharide metabolism (HP:0011012)3.05480242
37Abnormality of glycosaminoglycan metabolism (HP:0004371)3.05480242
38Tetraparesis (HP:0002273)3.02808071
39Thick nail (HP:0001805)2.97378350
40Urticaria (HP:0001025)2.95728953
41Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.95452472
42Glomerulonephritis (HP:0000099)2.88083203
43Neurofibrillary tangles (HP:0002185)2.84705950
44Periodontitis (HP:0000704)2.83970848
45Axonal loss (HP:0003447)2.83036452
46Increased serum ferritin (HP:0003281)2.73397338
47Recurrent pneumonia (HP:0006532)2.71628928
48Petechiae (HP:0000967)2.69565961
49Gingival bleeding (HP:0000225)2.68294556
50Arterial thrombosis (HP:0004420)2.67500521
51Pustule (HP:0200039)2.65478822
52Polyneuropathy (HP:0001271)2.65300671
53Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.64495167
54Cellulitis (HP:0100658)2.64486415
55Nephritis (HP:0000123)2.59171210
56Cleft eyelid (HP:0000625)2.59051364
57Apathy (HP:0000741)2.58778132
58Purpura (HP:0000979)2.57758515
59Encephalitis (HP:0002383)2.57728464
60Progressive neurologic deterioration (HP:0002344)2.56671505
61Nausea (HP:0002018)2.56103734
62Prostate neoplasm (HP:0100787)2.53547392
63Gastrointestinal infarctions (HP:0005244)2.51697677
64Keratoconjunctivitis sicca (HP:0001097)2.50772239
65Amyloidosis (HP:0011034)2.49671912
66Meningitis (HP:0001287)2.47447252
67Inappropriate behavior (HP:0000719)2.46498899
68Diminished motivation (HP:0000745)2.44651840
69Disinhibition (HP:0000734)2.44581724
70Recurrent lower respiratory tract infections (HP:0002783)2.43459536
71Anorexia (HP:0002039)2.41248001
72Complement deficiency (HP:0004431)2.40987789
73T lymphocytopenia (HP:0005403)2.39268563
74Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.38634196
75Abnormality of glycolipid metabolism (HP:0010969)2.38104803
76Abnormality of liposaccharide metabolism (HP:0010968)2.38104803
77Abnormality of glycosphingolipid metabolism (HP:0004343)2.38104803
78Autoimmune hemolytic anemia (HP:0001890)2.36364016
79Premature loss of primary teeth (HP:0006323)2.35883993
80Metaphyseal irregularity (HP:0003025)2.33925249
81Vertigo (HP:0002321)2.33142347
82Abnormality of the pericardium (HP:0001697)2.32903466
83Agnosia (HP:0010524)2.32724163
84Keratoconjunctivitis (HP:0001096)2.31904119
85Acne (HP:0001061)2.31031347
86Dysostosis multiplex (HP:0000943)2.30832937
87Nasal polyposis (HP:0100582)2.29673091
88Progressive visual loss (HP:0000529)2.27713096
89Abnormality of B cell number (HP:0010975)2.27680878
90Hepatosplenomegaly (HP:0001433)2.27111709
91IgA deficiency (HP:0002720)2.24764600
92Pulmonary embolism (HP:0002204)2.24641921
93Keratitis (HP:0000491)2.24557876
94Prolonged neonatal jaundice (HP:0006579)2.24459815
95Memory impairment (HP:0002354)2.23319394
96Leukocytosis (HP:0001974)2.21279362
97Lower limb hyperreflexia (HP:0002395)2.21274364
98Joint swelling (HP:0001386)2.18709952
99Generalized aminoaciduria (HP:0002909)2.18058324
100Hemoptysis (HP:0002105)2.15970484
101Abnormality of iron homeostasis (HP:0011031)2.15528691
102Abnormality of the pleura (HP:0002103)2.15073064
103Thin bony cortex (HP:0002753)2.14693211
104Abnormality of the nasal mucosa (HP:0000433)2.14246812
105B lymphocytopenia (HP:0010976)2.13962983
106Hemorrhage of the eye (HP:0011885)2.13637536
107Recurrent cutaneous fungal infections (HP:0011370)2.12888278
108Chronic mucocutaneous candidiasis (HP:0002728)2.12888278
109Osteomyelitis (HP:0002754)2.12070775
110Arthralgia (HP:0002829)2.08247945
111Recurrent bronchitis (HP:0002837)2.07371532
112Abnormality of the basal ganglia (HP:0002134)2.07246540
113Increased IgE level (HP:0003212)2.06985988
114Thoracolumbar scoliosis (HP:0002944)2.06955874
115Joint hemorrhage (HP:0005261)2.05928716
116Cerebral inclusion bodies (HP:0100314)2.05227079
117Glomerulopathy (HP:0100820)2.03711704
118Bone pain (HP:0002653)2.03404481
119Episodic fever (HP:0001954)2.01664095
120Esophageal neoplasm (HP:0100751)2.01566428
121Neoplasm of head and neck (HP:0012288)2.01566428
122Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.00623675
123Plagiocephaly (HP:0001357)1.99765746
124Abnormality of the vasculature of the conjunctiva (HP:0008054)1.99326297
125Neuronal loss in central nervous system (HP:0002529)1.98837972
126Abnormality of the endocardium (HP:0004306)1.98714761
127Loss of speech (HP:0002371)1.98417578
128Vertebral compression fractures (HP:0002953)1.97973559
129Gastrointestinal stroma tumor (HP:0100723)1.95422627
130IgG deficiency (HP:0004315)1.95254604
131Abnormality of T cell number (HP:0011839)1.94875836
132Urinary glycosaminoglycan excretion (HP:0003541)1.94736414
133Mucopolysacchariduria (HP:0008155)1.94736414
134Hematochezia (HP:0002573)1.93596807
135Gangrene (HP:0100758)1.92018590
136Myocardial infarction (HP:0001658)1.91362607
137Fused cervical vertebrae (HP:0002949)1.91251011
138Mesangial abnormality (HP:0001966)1.90532706
139Parakeratosis (HP:0001036)1.88208834
140Peritonitis (HP:0002586)1.87382027

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK4.70573741
2MAP3K144.59536154
3BLK4.56444225
4TBK14.26774938
5RIPK43.92317145
6IRAK43.42342868
7TYK23.36825918
8TAOK23.26555863
9IKBKE3.25437305
10PIM23.20471431
11IRAK32.91374449
12DDR22.83368541
13IKBKB2.62004375
14JAK32.52672708
15PRPF4B2.25951482
16TXK2.21589505
17JAK12.14055393
18TAOK11.98384668
19ERN11.87073916
20SIK31.82203569
21BMPR21.77931849
22MAP4K11.76000997
23MAP3K131.72575574
24CHUK1.62606070
25KIT1.61879208
26TGFBR21.60178706
27MAP3K31.59216012
28CSK1.48909213
29ABL21.46093902
30BMX1.41954087
31CDC42BPA1.41238322
32LATS21.39038119
33ZAP701.37455927
34SYK1.37212708
35MST41.30285082
36MATK1.27070514
37ARAF1.25146501
38CLK11.21400547
39IRAK21.20015367
40MAP3K51.18010764
41MARK31.17168449
42HCK1.16395290
43EIF2AK21.14697005
44IRAK11.13610484
45FGR1.12597149
46NME21.11838269
47PIM11.08434117
48MAP2K31.08419597
49LYN1.01323902
50EPHB10.98670904
51TYRO30.98007427
52DYRK30.95740297
53RPS6KA40.93916570
54JAK20.91019685
55SIK20.89385183
56ERBB30.89162787
57LCK0.88060341
58MAP3K120.83812084
59BTK0.80969193
60FGFR40.77701774
61MST1R0.76541452
62HIPK20.75405073
63STK40.72918427
64YES10.72807845
65MAP2K60.65646940
66DAPK30.64581763
67FES0.64043533
68PRKCD0.63309584
69ABL10.62521760
70SIK10.60914356
71TESK10.56065468
72PRKCQ0.54823610
73NEK90.54364580
74TAOK30.54316938
75ACVR1B0.53517604
76RIPK10.52872385
77EPHA30.51698853
78TRPM70.50735402
79PDGFRA0.49496611
80STK30.49482060
81EGFR0.49438906
82CSF1R0.48706145
83FGFR30.47097662
84GRK70.41670339
85ADRBK20.39295554
86DAPK20.39025895
87TEC0.38101028
88PLK20.34307967
89LRRK20.34029007
90STK100.33030253
91KSR20.30394382
92ERBB40.29496060
93MAPK70.27941626
94MAP3K10.27903413
95ICK0.27016451
96CDK40.26519521
97MOS0.24756045
98CDK140.24344314
99NUAK10.23232298
100PRKG20.22722074
101RPS6KA10.22675060
102MAPKAPK20.21480517
103FYN0.21062676
104RAF10.21024302
105CDK150.20336172
106TESK20.19897973
107GSK3A0.19884929
108MAP3K110.19680591
109TLK10.18167775
110STK240.17502393
111MAPK40.17177518
112PKN10.17127242
113CDK11A0.17060852
114RPS6KC10.17056676
115RPS6KL10.17056676
116CDK180.16160745
117DYRK1B0.16029441
118PRKCE0.15449099
119PDPK10.15238362
120PDK10.14638749
121RPS6KA50.14592490
122SRC0.14575332
123CAMKK20.13994408
124PDGFRB0.13879014
125PAK40.13399653
126IGF1R0.13235419
127BMPR1B0.10333392
128CDK60.09837500
129SGK10.09509199
130RPS6KA60.09240188
131INSR0.07049943
132MAP3K100.06613166

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.95014008
2Graft-versus-host disease_Homo sapiens_hsa053323.88833620
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.49169644
4Toll-like receptor signaling pathway_Homo sapiens_hsa046203.25739430
5Leishmaniasis_Homo sapiens_hsa051403.22874260
6Asthma_Homo sapiens_hsa053103.00672859
7RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.92961567
8Type I diabetes mellitus_Homo sapiens_hsa049402.70466574
9Staphylococcus aureus infection_Homo sapiens_hsa051502.66673920
10NOD-like receptor signaling pathway_Homo sapiens_hsa046212.57792315
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.54097599
12Rheumatoid arthritis_Homo sapiens_hsa053232.51867766
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.41792188
14Malaria_Homo sapiens_hsa051442.37557746
15Legionellosis_Homo sapiens_hsa051342.32134292
16Pertussis_Homo sapiens_hsa051332.29504291
17Influenza A_Homo sapiens_hsa051642.17685288
18Measles_Homo sapiens_hsa051622.12114087
19TNF signaling pathway_Homo sapiens_hsa046682.11981359
20African trypanosomiasis_Homo sapiens_hsa051432.02844711
21Tuberculosis_Homo sapiens_hsa051521.96270695
22Autoimmune thyroid disease_Homo sapiens_hsa053201.95201923
23Osteoclast differentiation_Homo sapiens_hsa043801.94176677
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.91789315
25Salmonella infection_Homo sapiens_hsa051321.83442728
26Herpes simplex infection_Homo sapiens_hsa051681.71175428
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.52893726
28Toxoplasmosis_Homo sapiens_hsa051451.51486653
29Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.49149779
30Chemokine signaling pathway_Homo sapiens_hsa040621.39641360
31Viral myocarditis_Homo sapiens_hsa054161.30231678
32Shigellosis_Homo sapiens_hsa051311.27638487
33Phagosome_Homo sapiens_hsa041451.21621836
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.18841945
35Hepatitis C_Homo sapiens_hsa051601.18400559
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.17497516
37B cell receptor signaling pathway_Homo sapiens_hsa046621.16286272
38Lysosome_Homo sapiens_hsa041421.15210534
39Hematopoietic cell lineage_Homo sapiens_hsa046401.14826484
40Antigen processing and presentation_Homo sapiens_hsa046121.06178582
41Apoptosis_Homo sapiens_hsa042101.03175608
42Hepatitis B_Homo sapiens_hsa051611.02269399
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98199926
44Prion diseases_Homo sapiens_hsa050200.97133161
45Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.96558216
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87780873
47Primary immunodeficiency_Homo sapiens_hsa053400.87207635
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83898074
49Amoebiasis_Homo sapiens_hsa051460.81559497
50Bladder cancer_Homo sapiens_hsa052190.74900214
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70546656
52Sulfur metabolism_Homo sapiens_hsa009200.65599552
53Sphingolipid metabolism_Homo sapiens_hsa006000.65217752
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.64484148
55Collecting duct acid secretion_Homo sapiens_hsa049660.63140006
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62914450
57Prolactin signaling pathway_Homo sapiens_hsa049170.61827447
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.59997938
59T cell receptor signaling pathway_Homo sapiens_hsa046600.59618898
60Tryptophan metabolism_Homo sapiens_hsa003800.55254105
61Other glycan degradation_Homo sapiens_hsa005110.51700554
62Acute myeloid leukemia_Homo sapiens_hsa052210.50734881
63Type II diabetes mellitus_Homo sapiens_hsa049300.50660207
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.50287710
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48773361
66Epstein-Barr virus infection_Homo sapiens_hsa051690.47057212
67Complement and coagulation cascades_Homo sapiens_hsa046100.46494805
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43035533
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.41194871
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.40542983
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38279598
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37382907
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36326512
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36135147
75HIF-1 signaling pathway_Homo sapiens_hsa040660.34978742
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34420635
77Folate biosynthesis_Homo sapiens_hsa007900.34301370
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.33893261
79Platelet activation_Homo sapiens_hsa046110.33376342
80Chronic myeloid leukemia_Homo sapiens_hsa052200.32634998
81Proteasome_Homo sapiens_hsa030500.28462369
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27816046
83Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.27278096
84Mineral absorption_Homo sapiens_hsa049780.24021740
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23314277
86Viral carcinogenesis_Homo sapiens_hsa052030.20862203
87Small cell lung cancer_Homo sapiens_hsa052220.19479528
88Dorso-ventral axis formation_Homo sapiens_hsa043200.18846721
89Caffeine metabolism_Homo sapiens_hsa002320.18109144
90Galactose metabolism_Homo sapiens_hsa000520.18001660
91PPAR signaling pathway_Homo sapiens_hsa033200.17908102
92Fructose and mannose metabolism_Homo sapiens_hsa000510.16963367
93Pancreatic cancer_Homo sapiens_hsa052120.16184889
94HTLV-I infection_Homo sapiens_hsa051660.16131527
95Systemic lupus erythematosus_Homo sapiens_hsa053220.15365354
96Vibrio cholerae infection_Homo sapiens_hsa051100.14447618
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.14152594
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.13198081
99Insulin resistance_Homo sapiens_hsa049310.10259070
100VEGF signaling pathway_Homo sapiens_hsa043700.09574673
101Proteoglycans in cancer_Homo sapiens_hsa052050.08902498
102Notch signaling pathway_Homo sapiens_hsa043300.08659743
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.06631441
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.06020444
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.04074313
106Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.02732041
107MAPK signaling pathway_Homo sapiens_hsa040100.00841948
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.00719802
109FoxO signaling pathway_Homo sapiens_hsa040680.00415223
110Pentose phosphate pathway_Homo sapiens_hsa00030-0.0085659
111Endocytosis_Homo sapiens_hsa04144-0.0047560

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