IL25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1otic vesicle formation (GO:0030916)8.27412043
2detection of chemical stimulus involved in sensory perception of taste (GO:0050912)7.57773313
3sensory perception of taste (GO:0050909)6.88028039
4icosanoid secretion (GO:0032309)6.76105331
5arachidonic acid secretion (GO:0050482)6.76105331
6detection of chemical stimulus involved in sensory perception (GO:0050907)6.55426727
7eye photoreceptor cell differentiation (GO:0001754)6.48838983
8photoreceptor cell differentiation (GO:0046530)6.48838983
9positive regulation of vesicle fusion (GO:0031340)6.16445860
10hepatocyte apoptotic process (GO:0097284)6.03196246
11lipoxygenase pathway (GO:0019372)5.89363582
12regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.87287177
13regulation of Rap GTPase activity (GO:0032317)5.81789092
14icosanoid transport (GO:0071715)5.60675616
15fatty acid derivative transport (GO:1901571)5.60675616
16positive regulation of male gonad development (GO:2000020)5.16950181
17phosphorylated carbohydrate dephosphorylation (GO:0046838)5.09708828
18inositol phosphate dephosphorylation (GO:0046855)5.09708828
19icosanoid biosynthetic process (GO:0046456)5.08724949
20fatty acid derivative biosynthetic process (GO:1901570)5.08724949
21positive regulation of extracellular matrix organization (GO:1903055)5.06276639
22positive regulation of fatty acid beta-oxidation (GO:0032000)5.00778185
23skin morphogenesis (GO:0043589)4.97361777
24carnitine shuttle (GO:0006853)4.93113849
25endocardial cushion morphogenesis (GO:0003203)4.88942678
26nephron tubule formation (GO:0072079)4.88687848
27limb bud formation (GO:0060174)4.79571150
28inositol phosphate catabolic process (GO:0071545)4.78091205
29regulation of male gonad development (GO:2000018)4.67071823
30long term synaptic depression (GO:0060292)4.57059498
31regulation of interleukin-8 secretion (GO:2000482)4.46874844
32regulation of centriole replication (GO:0046599)4.35322485
33cardiolipin metabolic process (GO:0032048)4.34331442
34heart valve formation (GO:0003188)4.29652594
35negative regulation of bone mineralization (GO:0030502)4.28917193
36notochord development (GO:0030903)4.25376180
37cellular response to antibiotic (GO:0071236)4.22218611
38negative regulation of interleukin-8 production (GO:0032717)4.20529771
39fatty acid transmembrane transport (GO:1902001)4.19838679
40leukotriene biosynthetic process (GO:0019370)4.15570595
41termination of signal transduction (GO:0023021)4.00080341
42epithelial structure maintenance (GO:0010669)3.98465605
43mast cell degranulation (GO:0043303)3.93254895
44mast cell activation involved in immune response (GO:0002279)3.93254895
45regulation of glycogen (starch) synthase activity (GO:2000465)3.90982429
46arachidonic acid metabolic process (GO:0019369)3.90469449
47cyclooxygenase pathway (GO:0019371)3.88693924
48long-chain fatty acid transport (GO:0015909)3.87825652
49biotin metabolic process (GO:0006768)3.86810328
50hepatocyte differentiation (GO:0070365)3.82875053
51negative regulation of glycogen biosynthetic process (GO:0045719)3.80585638
52termination of G-protein coupled receptor signaling pathway (GO:0038032)3.76134162
53negative regulation of biomineral tissue development (GO:0070168)3.73193709
54carnitine metabolic process (GO:0009437)3.68246590
55carnitine transmembrane transport (GO:1902603)3.67020050
56vesicle targeting (GO:0006903)3.58751571
57maintenance of gastrointestinal epithelium (GO:0030277)3.49991367
58positive regulation of fatty acid oxidation (GO:0046321)3.48711358
59glycerophospholipid catabolic process (GO:0046475)3.48409906
60negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.43980254
61prostaglandin biosynthetic process (GO:0001516)3.42409169
62prostanoid biosynthetic process (GO:0046457)3.42409169
63negative regulation of glycogen metabolic process (GO:0070874)3.41496059
64natural killer cell mediated cytotoxicity (GO:0042267)3.41221344
65natural killer cell mediated immunity (GO:0002228)3.41221344
66amino-acid betaine transport (GO:0015838)3.38999955
67carnitine transport (GO:0015879)3.38999955
68phospholipid catabolic process (GO:0009395)3.38789375
69negative regulation of acute inflammatory response (GO:0002674)3.34926859
70mammary gland development (GO:0030879)3.33573584
71cellular response to toxic substance (GO:0097237)3.32664359
72mesenchyme morphogenesis (GO:0072132)3.32077001
73regulation of vesicle fusion (GO:0031338)3.31751620
74positive regulation of Ras protein signal transduction (GO:0046579)3.30598066
75oligodendrocyte differentiation (GO:0048709)3.30282712
76negative regulation of protein oligomerization (GO:0032460)3.26708416
77phosphatidylinositol acyl-chain remodeling (GO:0036149)3.26692638
78negative regulation of chondrocyte differentiation (GO:0032331)3.26391535
79response to nicotine (GO:0035094)3.24196630
80Rap protein signal transduction (GO:0032486)3.17514046
81long-term synaptic potentiation (GO:0060291)3.13630899
82cranial suture morphogenesis (GO:0060363)3.12955564
83positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.11318833
84regulation of fatty acid beta-oxidation (GO:0031998)3.07507270
85long-chain fatty acid metabolic process (GO:0001676)3.06728037
86sensory perception of chemical stimulus (GO:0007606)3.06570217
87regulation of T-helper 2 cell differentiation (GO:0045628)3.06520821
88positive regulation of insulin receptor signaling pathway (GO:0046628)3.06492832
89fatty acid transport (GO:0015908)3.04277802
90polyol catabolic process (GO:0046174)3.00930274
91negative regulation by host of viral transcription (GO:0043922)3.00409046
92male sex determination (GO:0030238)2.96763467
93protein kinase C-activating G-protein coupled receptor signaling pathway (GO:0007205)2.94570058
94phosphatidylserine acyl-chain remodeling (GO:0036150)2.91066932
95positive regulation of fatty acid metabolic process (GO:0045923)2.90129501
96regulation of T cell cytokine production (GO:0002724)2.89644400
97negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.87485444
98positive regulation of fatty acid biosynthetic process (GO:0045723)2.86202846
99detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)12.5682572
100production of molecular mediator involved in inflammatory response (GO:0002532)10.2325584

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human5.25714098
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.78552852
3AR_21572438_ChIP-Seq_LNCaP_Human4.61886049
4ESR1_15608294_ChIP-ChIP_MCF-7_Human3.79365883
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.26957922
6IRF1_19129219_ChIP-ChIP_H3396_Human2.97689428
7PPAR_26484153_Chip-Seq_NCI-H1993_Human2.32187558
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.23204122
9FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.22827347
10PPARD_23208498_ChIP-Seq_MDA-MB-231_Human2.22780860
11TP53_18474530_ChIP-ChIP_U2OS_Human2.18526627
12ZNF217_24962896_ChIP-Seq_MCF-7_Human2.10252135
13SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.97355071
14DROSHA_22980978_ChIP-Seq_HELA_Human1.93777443
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.91254476
16AR_21909140_ChIP-Seq_LNCAP_Human1.77800833
17ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.77569092
18UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.77458905
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.77008305
20WT1_19549856_ChIP-ChIP_CCG9911_Human1.71493935
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70457618
22ZNF274_21170338_ChIP-Seq_K562_Hela1.65926289
23TP53_16413492_ChIP-PET_HCT116_Human1.58832409
24NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.58795794
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.54904336
26GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.52254510
27CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.50183205
28TRIM28_21343339_ChIP-Seq_HEK293_Human1.47683864
29TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46439066
30SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.42548873
31MTF2_20144788_ChIP-Seq_MESCs_Mouse1.41156874
32FUS_26573619_Chip-Seq_HEK293_Human1.40895344
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.40677621
34EZH2_22144423_ChIP-Seq_EOC_Human1.39315462
35STAT1_20625510_ChIP-Seq_HELA_Human1.37688405
36SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34780184
37SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34452416
38EWS_26573619_Chip-Seq_HEK293_Human1.32750024
39FOXM1_26456572_ChIP-Seq_MCF-7_Human1.27383551
40AHR_22903824_ChIP-Seq_MCF-7_Human1.27205432
41SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.26949467
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26623379
43RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.25136706
44GATA4_25053715_ChIP-Seq_YYC3_Human1.23655769
45AR_25329375_ChIP-Seq_VCAP_Human1.23384941
46GBX2_23144817_ChIP-Seq_PC3_Human1.18199907
47JARID2_20075857_ChIP-Seq_MESCs_Mouse1.18059103
48SOX2_20726797_ChIP-Seq_SW620_Human1.17327697
49RXR_22108803_ChIP-Seq_LS180_Human1.17270210
50NRF2_20460467_ChIP-Seq_MEFs_Mouse1.16657286
51NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.16657286
52CTNNB1_20460455_ChIP-Seq_HCT116_Human1.16302023
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16019065
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15790909
55ESR2_21235772_ChIP-Seq_MCF-7_Human1.15369864
56ELK4_26923725_Chip-Seq_MESODERM_Mouse1.13737158
57PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.13506219
58RUNX1_27514584_Chip-Seq_MCF-7_Human1.12549135
59SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10643216
60ARNT_22903824_ChIP-Seq_MCF-7_Human1.10432678
61POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.09418109
62EZH2_27294783_Chip-Seq_ESCs_Mouse1.07750958
63GF1B_26923725_Chip-Seq_HPCs_Mouse1.05170922
64SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04232053
65BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02740037
66CDX2_20551321_ChIP-Seq_CACO-2_Human1.02632211
67WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02174030
68FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.02031480
69PRDM14_20953172_ChIP-Seq_ESCs_Human1.01943763
70MYC_27129775_Chip-Seq_CORNEA_Mouse0.99764833
71SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.99316505
72JARID2_20064375_ChIP-Seq_MESCs_Mouse0.98953409
73WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98855025
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98583477
75SALL4_18804426_ChIP-ChIP_XEN_Mouse0.97716248
76JUN_21703547_ChIP-Seq_K562_Human0.97490702
77Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.95580778
78CJUN_26792858_Chip-Seq_BT549_Human0.94974446
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94573985
80LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93957586
81SMAD4_21799915_ChIP-Seq_A2780_Human0.93755868
82TP53_20018659_ChIP-ChIP_R1E_Mouse0.93470992
83RUNX1_22412390_ChIP-Seq_EML_Mouse0.93348707
84MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.91105840
85LXR_22158963_ChIP-Seq_LIVER_Mouse0.90959655
86ESR1_20079471_ChIP-ChIP_T-47D_Human0.89723558
87P300_19829295_ChIP-Seq_ESCs_Human0.89678284
88GF1_26923725_Chip-Seq_HPCs_Mouse0.89192512
89RING1B_27294783_Chip-Seq_NPCs_Mouse0.87936004
90SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.87800709
91SMAD4_21741376_ChIP-Seq_HESCs_Human0.87607026
92FOXA2_19822575_ChIP-Seq_HepG2_Human0.87595235
93EZH2_18974828_ChIP-Seq_MESCs_Mouse0.86448947
94RNF2_18974828_ChIP-Seq_MESCs_Mouse0.86448947
95POU3F2_20337985_ChIP-ChIP_501MEL_Human0.86367170
96TP63_23658742_ChIP-Seq_EP156T_Human0.85238141
97TBX3_20139965_ChIP-Seq_ESCs_Mouse0.85187046
98TBX3_20139965_ChIP-Seq_MESCs_Mouse0.84963378
99SOX2_27498859_Chip-Seq_STOMACH_Mouse0.84067728
100ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.83668158

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH6.42805254
2* MP0002148_abnormal_hypersensitivity_rea3.56315747
3MP0002736_abnormal_nociception_after3.20162913
4MP0003718_maternal_effect2.71146302
5MP0001968_abnormal_touch/_nociception2.59145632
6MP0005395_other_phenotype2.16693761
7MP0001986_abnormal_taste_sensitivity13.9791948
8MP0003436_decreased_susceptibility_to1.79258640
9MP0002168_other_aberrant_phenotype1.76818560
10MP0004036_abnormal_muscle_relaxation1.75024813
11MP0000538_abnormal_urinary_bladder1.72536949
12MP0005023_abnormal_wound_healing1.66409340
13MP0002295_abnormal_pulmonary_circulatio1.64139559
14MP0004264_abnormal_extraembryonic_tissu1.58978961
15MP0004742_abnormal_vestibular_system1.56961438
16MP0003638_abnormal_response/metabolism_1.54676690
17MP0005360_urolithiasis1.50095405
18MP0003787_abnormal_imprinting1.49901281
19MP0006138_congestive_heart_failure1.47169538
20MP0001666_abnormal_nutrient_absorption1.43246084
21MP0003880_abnormal_central_pattern1.41563080
22MP0005464_abnormal_platelet_physiology1.36268452
23MP0002249_abnormal_larynx_morphology1.34702862
24MP0004859_abnormal_synaptic_plasticity1.33494286
25MP0003221_abnormal_cardiomyocyte_apopto1.33098197
26MP0001905_abnormal_dopamine_level1.24159833
27MP0004270_analgesia1.23807080
28MP0009765_abnormal_xenobiotic_induced1.23398368
29MP0005377_hearing/vestibular/ear_phenot1.21241072
30MP0003878_abnormal_ear_physiology1.21241072
31MP0008874_decreased_physiological_sensi1.17491230
32MP0000534_abnormal_ureter_morphology1.16757954
33MP0008260_abnormal_autophagy1.15182050
34MP0010329_abnormal_lipoprotein_level1.13499388
35MP0003075_altered_response_to1.11066878
36MP0003566_abnormal_cell_adhesion1.08191163
37MP0004084_abnormal_cardiac_muscle1.04621220
38MP0004484_altered_response_of1.04137723
39MP0005423_abnormal_somatic_nervous0.99130299
40MP0004142_abnormal_muscle_tone0.97859063
41MP0005365_abnormal_bile_salt0.97227575
42MP0001348_abnormal_lacrimal_gland0.96551894
43MP0002653_abnormal_ependyma_morphology0.92527296
44MP0003172_abnormal_lysosome_physiology0.89433285
45MP0002282_abnormal_trachea_morphology0.88807235
46MP0004133_heterotaxia0.88662728
47MP0001486_abnormal_startle_reflex0.82398987
48MP0000428_abnormal_craniofacial_morphol0.81483888
49MP0001177_atelectasis0.79837854
50MP0010386_abnormal_urinary_bladder0.79786282
51MP0002928_abnormal_bile_duct0.79137816
52MP0005085_abnormal_gallbladder_physiolo0.78613279
53MP0002128_abnormal_blood_circulation0.77248433
54MP0001943_abnormal_respiration0.74176699
55MP0001533_abnormal_skeleton_physiology0.73343162
56MP0004085_abnormal_heartbeat0.72367215
57MP0003252_abnormal_bile_duct0.71036678
58MP0003300_gastrointestinal_ulcer0.70738326
59MP0001501_abnormal_sleep_pattern0.69746051
60MP0001664_abnormal_digestion0.68730138
61MP0002160_abnormal_reproductive_system0.67946127
62MP0002733_abnormal_thermal_nociception0.66977356
63MP0003635_abnormal_synaptic_transmissio0.66889342
64MP0004145_abnormal_muscle_electrophysio0.66212851
65MP0005164_abnormal_response_to0.63235435
66MP0002118_abnormal_lipid_homeostasis0.63021926
67MP0002822_catalepsy0.62215418
68MP0002063_abnormal_learning/memory/cond0.60993255
69MP0002233_abnormal_nose_morphology0.60823348
70MP0005166_decreased_susceptibility_to0.60604155
71MP0003195_calcinosis0.60141128
72MP0002557_abnormal_social/conspecific_i0.59576394
73MP0001270_distended_abdomen0.58895428
74MP0008877_abnormal_DNA_methylation0.57982397
75MP0002139_abnormal_hepatobiliary_system0.56944067
76MP0003091_abnormal_cell_migration0.56659130
77* MP0000490_abnormal_crypts_of0.56276416
78MP0000372_irregular_coat_pigmentation0.56035199
79MP0000762_abnormal_tongue_morphology0.55638350
80MP0002896_abnormal_bone_mineralization0.55293511
81MP0002572_abnormal_emotion/affect_behav0.55123618
82MP0002254_reproductive_system_inflammat0.54541498
83MP0010352_gastrointestinal_tract_polyps0.52709576
84MP0002067_abnormal_sensory_capabilities0.51110794
85MP0003122_maternal_imprinting0.50643762
86MP0004858_abnormal_nervous_system0.48878211
87MP0001340_abnormal_eyelid_morphology0.48747828
88MP0009046_muscle_twitch0.48471960
89MP0005623_abnormal_meninges_morphology0.47024118
90MP0000747_muscle_weakness0.46374105
91MP0002272_abnormal_nervous_system0.45685005
92MP0003755_abnormal_palate_morphology0.44568176
93MP0004811_abnormal_neuron_physiology0.44436643
94* MP0005000_abnormal_immune_tolerance0.43852338
95MP0000049_abnormal_middle_ear0.43403062
96MP0009643_abnormal_urine_homeostasis0.41806285
97MP0008873_increased_physiological_sensi0.40185367
98MP0001765_abnormal_ion_homeostasis0.40112589
99MP0004019_abnormal_vitamin_homeostasis0.39359389
100MP0004087_abnormal_muscle_fiber0.38230742

Predicted human phenotypes

RankGene SetZ-score
111 pairs of ribs (HP:0000878)6.14748221
2True hermaphroditism (HP:0010459)5.82257469
3Sex reversal (HP:0012245)5.78633003
4Abnormal sex determination (HP:0012244)5.78633003
5Neonatal short-limb short stature (HP:0008921)5.72817385
6Right ventricular cardiomyopathy (HP:0011663)5.40058236
7Bronchomalacia (HP:0002780)5.15283031
8Aplasia/Hypoplasia of the sternum (HP:0006714)4.52649269
9Gait imbalance (HP:0002141)4.35634935
10Chronic sinusitis (HP:0011109)4.32416976
11Congenital primary aphakia (HP:0007707)4.20877890
12Vascular calcification (HP:0004934)4.18206062
13Respiratory distress (HP:0002098)3.92954432
14Cardiovascular calcification (HP:0011915)3.83765281
15Missing ribs (HP:0000921)3.71671601
16Nephrogenic diabetes insipidus (HP:0009806)3.58957370
17Hypokinesia (HP:0002375)3.58180776
18Decreased central vision (HP:0007663)3.52806396
19Recurrent gram-negative bacterial infections (HP:0005420)3.49616885
20Mitral stenosis (HP:0001718)3.42701783
21Vaginal atresia (HP:0000148)3.42603062
22Genital tract atresia (HP:0001827)3.41230917
23Focal motor seizures (HP:0011153)3.36865336
24Fibular hypoplasia (HP:0003038)3.34892626
25Scanning speech (HP:0002168)3.30799095
26Medial flaring of the eyebrow (HP:0010747)3.28363095
27Poor coordination (HP:0002370)3.23007754
28Ketoacidosis (HP:0001993)3.13239666
29Distal lower limb muscle weakness (HP:0009053)3.03672871
30Tibial bowing (HP:0002982)3.00679273
31Abnormal vertebral ossification (HP:0100569)2.99164886
32Vertebral hypoplasia (HP:0008417)2.96444932
33Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.96444932
34Hepatoblastoma (HP:0002884)2.96440921
35Visual hallucinations (HP:0002367)2.89732116
36Supranuclear gaze palsy (HP:0000605)2.86117291
37Esophageal varix (HP:0002040)2.82722688
38Hyperglycinuria (HP:0003108)2.76813070
39Aplasia/Hypoplasia of the scapulae (HP:0006713)2.69029812
40Hypoplastic scapulae (HP:0000882)2.69029812
41Cone-rod dystrophy (HP:0000548)2.68743733
42Abnormality of liposaccharide metabolism (HP:0010968)2.66544426
43Abnormality of glycosphingolipid metabolism (HP:0004343)2.66544426
44Abnormality of glycolipid metabolism (HP:0010969)2.66544426
45Prolonged QT interval (HP:0001657)2.66482431
46Broad foot (HP:0001769)2.65070082
47Epiphyseal dysplasia (HP:0002656)2.62733602
48Micronodular cirrhosis (HP:0001413)2.62211118
49Hyperammonemia (HP:0001987)2.56073381
50Interstitial pulmonary disease (HP:0006530)2.49725282
51Ventricular arrhythmia (HP:0004308)2.49085016
52Progressive neurologic deterioration (HP:0002344)2.48179224
53Bundle branch block (HP:0011710)2.46917056
54Tracheomalacia (HP:0002779)2.40892648
55Glossoptosis (HP:0000162)2.40552484
56Ulnar claw (HP:0001178)2.39530363
57Coxa valga (HP:0002673)2.29810345
58Relative macrocephaly (HP:0004482)2.29793339
59Abnormality of renal resorption (HP:0011038)2.29403806
60Glucose intolerance (HP:0000833)2.29399466
61Impulsivity (HP:0100710)2.25740078
62Abnormality of carpal bone ossification (HP:0006257)2.23146354
63Pancreatic fibrosis (HP:0100732)2.22999590
64Bradycardia (HP:0001662)2.22257514
65Abnormality of glycine metabolism (HP:0010895)2.20709755
66Abnormality of serine family amino acid metabolism (HP:0010894)2.20709755
67Bifid scrotum (HP:0000048)2.19201647
68Progressive external ophthalmoplegia (HP:0000590)2.16324707
69Abnormality of the right ventricle (HP:0001707)2.16128642
70Global brain atrophy (HP:0002283)2.11444885
71Left ventricular hypertrophy (HP:0001712)2.09426456
72Aplasia/Hypoplasia of the lens (HP:0008063)2.08565962
73Male pseudohermaphroditism (HP:0000037)2.07399730
74Akinesia (HP:0002304)2.06992913
75Supernumerary spleens (HP:0009799)2.06758838
76Turricephaly (HP:0000262)2.03939776
77Abnormality of the fetal cardiovascular system (HP:0010948)2.03740155
78Abnormal umbilical cord blood vessels (HP:0011403)2.03740155
79Single umbilical artery (HP:0001195)2.03740155
80Peripheral hypomyelination (HP:0007182)2.03284732
81Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.02691485
82Short clavicles (HP:0000894)2.01940238
83Aplasia/Hypoplasia of the fibula (HP:0006492)1.99241583
84Sprengel anomaly (HP:0000912)1.98281874
85Osteomalacia (HP:0002749)1.96876819
86Asplenia (HP:0001746)1.94693632
87Nonimmune hydrops fetalis (HP:0001790)1.94576588
88Curly hair (HP:0002212)1.92853228
89Renal tubular acidosis (HP:0001947)1.90521766
90Diminished movement (HP:0002374)1.90418497
91Sudden cardiac death (HP:0001645)1.90020706
92Opisthotonus (HP:0002179)1.86806788
93Renal cortical cysts (HP:0000803)1.85924240
94Thin ribs (HP:0000883)1.85457302
95Upper limb muscle weakness (HP:0003484)1.83098592
96Apathy (HP:0000741)1.81039126
97Poor eye contact (HP:0000817)1.80585069
98Patent foramen ovale (HP:0001655)1.78585208
99Aplasia/Hypoplasia of the clavicles (HP:0006710)1.78564775
100Syncope (HP:0001279)1.76585686

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB37.07975595
2MAPKAPK55.68365172
3MKNK15.11538049
4TRPM74.01792561
5KSR23.84745320
6RAF13.60300515
7DMPK3.58796122
8EPHA43.38672395
9NME13.11794354
10KSR13.03657569
11BMPR1B2.43479690
12BMPR22.38531164
13IRAK22.11332514
14PAK62.01384953
15PAK31.98881562
16RPS6KA51.90559687
17CDK31.60278986
18RPS6KB21.41256794
19MAP2K11.29307636
20TLK11.22438433
21NTRK31.14863068
22TEC1.07024451
23PRKCQ1.00346149
24MET0.98663205
25CAMK2A0.98270324
26PIK3CG0.94926204
27CSNK1A1L0.92257025
28BCR0.90103177
29BTK0.87592204
30CSF1R0.85126827
31FGFR20.84291124
32RPS6KA20.83552447
33MAPKAPK20.83467188
34HCK0.75798649
35ARAF0.75045663
36CSNK1G30.74940056
37ITK0.73614973
38MAP3K20.73090266
39TYK20.70601960
40BUB10.69789769
41IRAK10.64735651
42MAPK70.63874978
43MAPK40.60916624
44CAMK2B0.59172002
45CSNK1G20.53929002
46RIPK40.52393578
47CSNK1G10.50258063
48ROCK10.47648072
49CAMK2G0.45833262
50SGK20.44206246
51PRKACB0.43390512
52PRKCD0.42747133
53PRKACG0.41709030
54SIK30.40524554
55CAMK2D0.40382541
56RPS6KL10.39674379
57RPS6KC10.39674379
58PRKCH0.36291821
59RPS6KA10.35453382
60PRKACA0.35188560
61SGK2230.35178807
62SGK4940.35178807
63RPS6KA60.34443278
64CAMK10.34080363
65EGFR0.33147070
66PRKCE0.32082488
67DDR20.31948462
68PRKAA20.31153473
69SYK0.29213508
70PTK20.28100944
71MAP3K90.27926466
72PLK20.27452071
73PRKCG0.26863210
74PDPK10.24367233
75STK30.24364928
76PIM20.24214359
77PRKCA0.24193182
78FRK0.23311451
79IGF1R0.22488455
80MATK0.22091686
81FGR0.21039369
82HIPK20.19993237
83TBK10.19868402
84SGK30.19487477
85JAK20.17671793
86CDC42BPA0.16432173
87NUAK10.16339622
88PRKCZ0.15933950
89SRC0.14642238
90FER0.14455936
91CHUK0.14320876
92MARK10.13817440
93ABL10.13464059
94PRKG10.12532561
95MAP2K20.12422389
96CDK60.11663526
97IKBKE0.09520573
98MAPK30.09333416
99UHMK10.08687797
100TNIK0.08468791

Predicted pathways (KEGG)

RankGene SetZ-score
1Taste transduction_Homo sapiens_hsa047424.20678173
2Carbohydrate digestion and absorption_Homo sapiens_hsa049733.97764287
3Choline metabolism in cancer_Homo sapiens_hsa052313.86085316
4Arachidonic acid metabolism_Homo sapiens_hsa005903.36895557
5Glycerolipid metabolism_Homo sapiens_hsa005612.65098281
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.53975812
7Serotonergic synapse_Homo sapiens_hsa047262.51816605
8Linoleic acid metabolism_Homo sapiens_hsa005912.48539533
9Phospholipase D signaling pathway_Homo sapiens_hsa040722.44929676
10Long-term depression_Homo sapiens_hsa047302.41454237
11Ovarian steroidogenesis_Homo sapiens_hsa049132.33197236
12Glycerophospholipid metabolism_Homo sapiens_hsa005642.01403112
13Phosphatidylinositol signaling system_Homo sapiens_hsa040701.99882339
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.92552449
15Dorso-ventral axis formation_Homo sapiens_hsa043201.89819957
16Vitamin B6 metabolism_Homo sapiens_hsa007501.89603292
17Fatty acid degradation_Homo sapiens_hsa000711.88121011
18Ether lipid metabolism_Homo sapiens_hsa005651.75407588
19VEGF signaling pathway_Homo sapiens_hsa043701.59305393
20Platelet activation_Homo sapiens_hsa046111.46846078
21GnRH signaling pathway_Homo sapiens_hsa049121.36638080
22Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.35968305
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.31992374
24Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.23267442
25Glutamatergic synapse_Homo sapiens_hsa047241.22537158
26Non-homologous end-joining_Homo sapiens_hsa034501.19871923
27Renal cell carcinoma_Homo sapiens_hsa052111.09973454
28Primary bile acid biosynthesis_Homo sapiens_hsa001201.09457327
29Butanoate metabolism_Homo sapiens_hsa006500.99739972
30Vascular smooth muscle contraction_Homo sapiens_hsa042700.98776448
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98350184
32Type II diabetes mellitus_Homo sapiens_hsa049300.97904535
33Colorectal cancer_Homo sapiens_hsa052100.96478279
34Fatty acid metabolism_Homo sapiens_hsa012120.93310824
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93309118
36B cell receptor signaling pathway_Homo sapiens_hsa046620.89314884
37Gap junction_Homo sapiens_hsa045400.88219307
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86786537
39Long-term potentiation_Homo sapiens_hsa047200.85338882
40Endometrial cancer_Homo sapiens_hsa052130.83839577
41Cocaine addiction_Homo sapiens_hsa050300.83663962
42Toxoplasmosis_Homo sapiens_hsa051450.83306418
43MAPK signaling pathway_Homo sapiens_hsa040100.83115177
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.79214348
45Nitrogen metabolism_Homo sapiens_hsa009100.77428782
46PPAR signaling pathway_Homo sapiens_hsa033200.75481860
47Pancreatic cancer_Homo sapiens_hsa052120.75469250
48ErbB signaling pathway_Homo sapiens_hsa040120.73526168
49Oxytocin signaling pathway_Homo sapiens_hsa049210.72195305
50Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71855835
51Inositol phosphate metabolism_Homo sapiens_hsa005620.70908265
52Leishmaniasis_Homo sapiens_hsa051400.70378574
53Insulin resistance_Homo sapiens_hsa049310.65560002
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63716075
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62931344
56Non-small cell lung cancer_Homo sapiens_hsa052230.62539856
57Dilated cardiomyopathy_Homo sapiens_hsa054140.61135128
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60491179
59Acute myeloid leukemia_Homo sapiens_hsa052210.59748104
60Circadian entrainment_Homo sapiens_hsa047130.58754980
61Insulin secretion_Homo sapiens_hsa049110.57545986
62Chronic myeloid leukemia_Homo sapiens_hsa052200.57116180
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55136404
64Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54842504
65cAMP signaling pathway_Homo sapiens_hsa040240.53895953
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53200335
67GABAergic synapse_Homo sapiens_hsa047270.52658417
68Olfactory transduction_Homo sapiens_hsa047400.52184919
69Melanogenesis_Homo sapiens_hsa049160.50809552
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49898836
71Amoebiasis_Homo sapiens_hsa051460.48881194
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48724388
73Glioma_Homo sapiens_hsa052140.46778341
74Estrogen signaling pathway_Homo sapiens_hsa049150.45599590
75Tryptophan metabolism_Homo sapiens_hsa003800.44995027
76Tight junction_Homo sapiens_hsa045300.42940673
77Proteoglycans in cancer_Homo sapiens_hsa052050.41764582
78Melanoma_Homo sapiens_hsa052180.41684152
79Morphine addiction_Homo sapiens_hsa050320.40948898
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40886541
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.40356322
82Amphetamine addiction_Homo sapiens_hsa050310.40139093
83Ras signaling pathway_Homo sapiens_hsa040140.38437090
84Cholinergic synapse_Homo sapiens_hsa047250.37928239
85Dopaminergic synapse_Homo sapiens_hsa047280.37529621
86Fructose and mannose metabolism_Homo sapiens_hsa000510.36559411
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.35793743
88Hepatitis B_Homo sapiens_hsa051610.35661568
89Pancreatic secretion_Homo sapiens_hsa049720.34642135
90Bladder cancer_Homo sapiens_hsa052190.33500362
91Gastric acid secretion_Homo sapiens_hsa049710.31847197
92Rap1 signaling pathway_Homo sapiens_hsa040150.30305185
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29980647
94Glucagon signaling pathway_Homo sapiens_hsa049220.29352098
95Bile secretion_Homo sapiens_hsa049760.28206936
96Hippo signaling pathway_Homo sapiens_hsa043900.28037641
97Arginine biosynthesis_Homo sapiens_hsa002200.27623718
98Nicotine addiction_Homo sapiens_hsa050330.27577676
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.27370149
100Prostate cancer_Homo sapiens_hsa052150.27193599

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