IL22RA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the class II cytokine receptor family. The encoded soluble protein specifically binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface receptor. The encoded protein may be important in the regulation of inflammatory response, and has been implicated in the regulation of tumorigenesis in the colon. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)7.54714410
2ribosomal small subunit assembly (GO:0000028)7.31556386
3translational termination (GO:0006415)7.23799604
4maturation of SSU-rRNA (GO:0030490)6.85777442
5ribosomal small subunit biogenesis (GO:0042274)6.81378343
6translational elongation (GO:0006414)6.19713534
7hemidesmosome assembly (GO:0031581)6.04346283
8lymphoid progenitor cell differentiation (GO:0002320)5.96965668
9cellular extravasation (GO:0045123)5.88775794
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.86379383
11wound healing, spreading of epidermal cells (GO:0035313)5.81844392
12protein targeting to ER (GO:0045047)5.74066142
13cotranslational protein targeting to membrane (GO:0006613)5.73720901
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.65012276
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.65012276
16ribosomal large subunit biogenesis (GO:0042273)5.55646802
17establishment of protein localization to endoplasmic reticulum (GO:0072599)5.53849710
18viral life cycle (GO:0019058)5.41835581
19cellular protein complex disassembly (GO:0043624)5.41713945
20protein localization to endoplasmic reticulum (GO:0070972)5.36020451
21nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.28511700
22translational initiation (GO:0006413)5.07906274
23desmosome organization (GO:0002934)5.06008125
24antigen processing and presentation of endogenous antigen (GO:0019883)4.98845536
25regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.94109974
26interferon-gamma secretion (GO:0072643)4.80701252
27protein complex disassembly (GO:0043241)4.70026740
28immunoglobulin mediated immune response (GO:0016064)4.53178460
29definitive hemopoiesis (GO:0060216)4.48202594
30macromolecular complex disassembly (GO:0032984)4.31687220
31DNA deamination (GO:0045006)4.18081752
32adhesion of symbiont to host cell (GO:0044650)4.15194705
33virion attachment to host cell (GO:0019062)4.15194705
34interferon-gamma-mediated signaling pathway (GO:0060333)4.12468788
35regulation of antigen processing and presentation (GO:0002577)4.09200884
36regulation of dendritic cell antigen processing and presentation (GO:0002604)4.08911624
37negative regulation of cell fate specification (GO:0009996)4.01588599
38protein targeting to membrane (GO:0006612)3.90990191
39phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.87071800
40antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.84575330
41antigen processing and presentation via MHC class Ib (GO:0002475)3.83875836
42negative regulation of erythrocyte differentiation (GO:0045647)3.81702380
43wound healing, spreading of cells (GO:0044319)3.81289655
44bone resorption (GO:0045453)3.80691236
45glycosphingolipid catabolic process (GO:0046479)3.80231950
46dendritic cell chemotaxis (GO:0002407)3.72704707
47B cell mediated immunity (GO:0019724)3.70200958
48sphingoid metabolic process (GO:0046519)3.68707482
49detection of external biotic stimulus (GO:0098581)3.63952501
50negative regulation of interleukin-2 production (GO:0032703)3.63376146
51megakaryocyte development (GO:0035855)3.62491705
52dendritic cell migration (GO:0036336)3.60764595
53positive regulation of cellular amide metabolic process (GO:0034250)3.53261033
54iron ion import (GO:0097286)3.52006459
55leukocyte migration involved in inflammatory response (GO:0002523)3.51994444
56T-helper 1 type immune response (GO:0042088)3.51947322
57regulation of B cell differentiation (GO:0045577)3.51626596
58sphingosine metabolic process (GO:0006670)3.51589649
59nuclear-transcribed mRNA catabolic process (GO:0000956)3.50508185
60adhesion of symbiont to host (GO:0044406)3.49995770
61negative regulation of glycoprotein biosynthetic process (GO:0010561)3.47676595
62glycolipid catabolic process (GO:0019377)3.45983750
63keratinization (GO:0031424)3.45892337
64negative regulation of stress fiber assembly (GO:0051497)3.43439875
65positive regulation of bone resorption (GO:0045780)3.38749428
66positive regulation of bone remodeling (GO:0046852)3.38749428
67angiogenesis involved in wound healing (GO:0060055)3.38325615
68negative regulation by host of viral transcription (GO:0043922)3.37012876
69mRNA catabolic process (GO:0006402)3.35028254
70peptide catabolic process (GO:0043171)3.33184086
71ribonucleoprotein complex biogenesis (GO:0022613)3.32963327
72T cell costimulation (GO:0031295)3.28368443
73regulation of gamma-delta T cell activation (GO:0046643)3.28343191
74regulation of cardioblast differentiation (GO:0051890)3.23463422
75lymphocyte costimulation (GO:0031294)3.23454381
76neutrophil activation involved in immune response (GO:0002283)3.22990573
77ceramide catabolic process (GO:0046514)3.21086933
78chronic inflammatory response (GO:0002544)3.19862625
79bone morphogenesis (GO:0060349)3.18727734
80regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.17578034
81positive regulation of B cell differentiation (GO:0045579)3.17458394
82detection of bacterium (GO:0016045)3.16980766
83detection of biotic stimulus (GO:0009595)3.15418747
84cellular response to interferon-gamma (GO:0071346)3.15366020
85response to muramyl dipeptide (GO:0032495)3.15221719
86RNA catabolic process (GO:0006401)3.13410979
87regulation of hypersensitivity (GO:0002883)3.11928574
88motile cilium assembly (GO:0044458)3.10679392
89activated T cell proliferation (GO:0050798)3.09923753
90negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.08779883
91NIK/NF-kappaB signaling (GO:0038061)3.04462089
923-UTR-mediated mRNA stabilization (GO:0070935)3.03609846
93regulation of histone H3-K27 methylation (GO:0061085)3.01936472
94regulation of gamma-delta T cell differentiation (GO:0045586)2.99574871
95regulation of mast cell activation (GO:0033003)2.99261469
96vascular endothelial growth factor signaling pathway (GO:0038084)2.96366972
97regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.96259149
98germinal center formation (GO:0002467)2.96013110
99myeloid dendritic cell activation (GO:0001773)2.95955802
100regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.95283986
101alternative mRNA splicing, via spliceosome (GO:0000380)2.94098692
102regulation of water loss via skin (GO:0033561)2.93373185
103regulation of integrin activation (GO:0033623)2.91895571
104detection of other organism (GO:0098543)2.91854112
105positive regulation of granulocyte chemotaxis (GO:0071624)2.90509165
106positive regulation of gamma-delta T cell activation (GO:0046645)2.90267683
107negative regulation of axon extension involved in axon guidance (GO:0048843)2.90018342
108diol metabolic process (GO:0034311)2.89102872
109positive regulation of neutrophil chemotaxis (GO:0090023)2.88058266
110positive regulation of neutrophil migration (GO:1902624)2.88058266
111macrophage differentiation (GO:0030225)2.87575713
112regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.87505519
113positive regulation of mast cell activation (GO:0033005)2.87504601
114neutrophil mediated immunity (GO:0002446)2.87398849
115negative regulation of nitric oxide biosynthetic process (GO:0045019)2.85956102
116response to xenobiotic stimulus (GO:0009410)2.85660514
117positive regulation of mast cell degranulation (GO:0043306)2.85161313
118positive regulation of mast cell activation involved in immune response (GO:0033008)2.85161313
119mature B cell differentiation involved in immune response (GO:0002313)2.84973868
120collagen catabolic process (GO:0030574)2.84225218
121establishment of skin barrier (GO:0061436)2.84183935
122response to peptidoglycan (GO:0032494)2.84154751
123multicellular organismal catabolic process (GO:0044243)2.83599367
124myeloid dendritic cell differentiation (GO:0043011)2.81222369
125oligosaccharide catabolic process (GO:0009313)2.80310007
126lymphocyte chemotaxis (GO:0048247)2.79491396
127peptidyl-tyrosine autophosphorylation (GO:0038083)2.79486944
128pinocytosis (GO:0006907)2.78743216
129regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.78636223
130negative regulation of epidermal cell differentiation (GO:0045605)2.78402608
131response to interferon-gamma (GO:0034341)2.77943613
132neutrophil chemotaxis (GO:0030593)2.77489531
133cellular response to ethanol (GO:0071361)2.76569476
134negative regulation of interleukin-12 production (GO:0032695)2.73878435
135lipoxygenase pathway (GO:0019372)2.73606427
136respiratory burst (GO:0045730)2.72822623
137cellular response to thyroid hormone stimulus (GO:0097067)2.72117970
138translation (GO:0006412)2.71889024
139positive regulation of T cell chemotaxis (GO:0010820)2.70862701
140regulation of T cell chemotaxis (GO:0010819)2.70862701
141neutrophil migration (GO:1990266)2.70563669
142fat-soluble vitamin biosynthetic process (GO:0042362)2.69341384
143positive regulation of toll-like receptor signaling pathway (GO:0034123)2.69245709
144leukotriene biosynthetic process (GO:0019370)2.68149095
145negative regulation of cell fate commitment (GO:0010454)2.67953210
146positive regulation of respiratory burst (GO:0060267)2.67802487
147regulation of mast cell activation involved in immune response (GO:0033006)2.67054542
148angiotensin maturation (GO:0002003)2.66003399
149positive regulation of tissue remodeling (GO:0034105)2.64780712
150granulocyte chemotaxis (GO:0071621)2.64301464
151positive regulation of monocyte chemotaxis (GO:0090026)2.63424048
152regulation of necroptotic process (GO:0060544)2.63087780
153leukotriene metabolic process (GO:0006691)2.62589135
154granulocyte migration (GO:0097530)2.62112648
155cyclooxygenase pathway (GO:0019371)2.61628594
156proteasome assembly (GO:0043248)2.61012389
157osteoclast differentiation (GO:0030316)2.60235461
158negative regulation of interferon-gamma production (GO:0032689)2.59896559
159positive regulation of cell adhesion mediated by integrin (GO:0033630)2.58544890
160adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.57946974
161keratinocyte proliferation (GO:0043616)2.57900629
162positive regulation of glycoprotein biosynthetic process (GO:0010560)2.57584740
163positive regulation of cardiac muscle cell differentiation (GO:2000727)2.57406848
164negative regulation of T cell mediated immunity (GO:0002710)2.56180438
165regulation of B cell receptor signaling pathway (GO:0050855)2.56085934
166import into cell (GO:0098657)2.55589690
167adaptive immune response (GO:0002250)2.54752086
168platelet dense granule organization (GO:0060155)2.54554852
169negative regulation of epidermis development (GO:0045683)2.53789181
170positive regulation of DNA-templated transcription, initiation (GO:2000144)2.52975091
171negative regulation of interleukin-1 beta production (GO:0032691)2.52930579
172keratinocyte differentiation (GO:0030216)2.52057818
173positive regulation of interleukin-4 production (GO:0032753)2.52004266
174collagen metabolic process (GO:0032963)2.51938078
175positive regulation of leukocyte degranulation (GO:0043302)2.51724165
176positive regulation of chemokine secretion (GO:0090197)2.51555988
177superoxide anion generation (GO:0042554)2.50887810
178negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.50671578
179L-fucose catabolic process (GO:0042355)2.50544807
180fucose catabolic process (GO:0019317)2.50544807
181L-fucose metabolic process (GO:0042354)2.50544807
182B cell receptor signaling pathway (GO:0050853)2.50124771
183establishment of protein localization to membrane (GO:0090150)2.50024575
184keratinocyte development (GO:0003334)2.49363039
185cell fate commitment involved in formation of primary germ layer (GO:0060795)2.48697056
186amino sugar catabolic process (GO:0046348)2.48019715
187positive regulation of antigen processing and presentation (GO:0002579)2.47914017
188regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.47016924
189positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.46032300
190positive regulation of Cdc42 GTPase activity (GO:0043089)2.44672727

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.70797492
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.29925700
3SCL_19346495_ChIP-Seq_HPC-7_Human3.22909099
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.06117135
5Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.86289726
6MYB_21317192_ChIP-Seq_ERMYB_Mouse2.86179106
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.80119347
8E2F7_22180533_ChIP-Seq_HELA_Human2.72686775
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.64091463
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.56733805
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.47832081
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.44025529
13GATA1_22025678_ChIP-Seq_K562_Human2.40648237
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.33547264
15ZNF263_19887448_ChIP-Seq_K562_Human2.24340948
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.24120549
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.22638679
18VDR_21846776_ChIP-Seq_THP-1_Human2.19676324
19CDX2_19796622_ChIP-Seq_MESCs_Mouse2.18535215
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.17459727
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.15554875
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.15020044
23VDR_24787735_ChIP-Seq_THP-1_Human2.10604612
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.07333767
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.06794117
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.05354129
27MYC_22102868_ChIP-Seq_BL_Human2.00854155
28TP63_17297297_ChIP-ChIP_HaCaT_Human11.8183293
29P63_26484246_Chip-Seq_KERATINOCYTES_Human1.90135314
30IRF8_21731497_ChIP-ChIP_J774_Mouse1.86242857
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.85590408
32SPI1_23547873_ChIP-Seq_NB4_Human1.84936486
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.84189044
34VDR_22108803_ChIP-Seq_LS180_Human1.83303864
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.81062816
36ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.79699401
37MYC_19079543_ChIP-ChIP_MESCs_Mouse1.79579198
38TCF7_22412390_ChIP-Seq_EML_Mouse1.75024811
39NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.75007382
40SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.74517516
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72826027
42BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.71177770
43PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.68648834
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.68033325
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.67134609
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65155717
47SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61983469
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.58463794
49NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.57593889
50TCF4_18268006_ChIP-ChIP_LS174T_Human1.57549621
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.57041892
52MYB_26560356_Chip-Seq_TH2_Human1.53504194
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.52321128
54PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.52048035
55UTX_26944678_Chip-Seq_JUKART_Human1.51497214
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.49677195
57BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49068728
58SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.47540797
59SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.47540797
60VDR_24763502_ChIP-Seq_THP-1_Human1.46838185
61CLOCK_20551151_ChIP-Seq_293T_Human1.42850820
62* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.42833212
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.42661697
64FLI1_27457419_Chip-Seq_LIVER_Mouse1.41960607
65MAF_26560356_Chip-Seq_TH1_Human1.37692395
66IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.36983156
67ESR1_21235772_ChIP-Seq_MCF-7_Human1.35008812
68* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.34448454
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33036598
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.32339399
71STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.29241336
72MYB_26560356_Chip-Seq_TH1_Human1.28964990
73STAT4_19710469_ChIP-ChIP_TH1__Mouse1.28832368
74RUNX1_22412390_ChIP-Seq_EML_Mouse1.27827028
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27753192
76NRF2_20460467_ChIP-Seq_MEFs_Mouse1.27330985
77NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.27330985
78TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26240219
79TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26169969
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24426995
81NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.24240176
82* TP63_23658742_ChIP-Seq_EP156T_Human1.23495557
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.23184328
84FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22415017
85* RUNX_20019798_ChIP-Seq_JUKART_Human1.21761080
86GATA2_21666600_ChIP-Seq_HMVEC_Human1.21746446
87BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.21525171
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21340918
89CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.21292502
90PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20114032
91CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.17504731
92* CRX_20693478_ChIP-Seq_RETINA_Mouse1.16567120
93NANOG_18555785_Chip-Seq_ESCs_Mouse1.15021764
94ELK3_25401928_ChIP-Seq_HUVEC_Human1.14225873
95ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14174046
96SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09314747
97IRF8_27001747_Chip-Seq_BMDM_Mouse1.09051496
98* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08583215
99* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.08087885
100E2F1_18555785_Chip-Seq_ESCs_Mouse1.07149511
101CMYC_18555785_Chip-Seq_ESCs_Mouse1.05433614
102KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05347779
103EGR1_19032775_ChIP-ChIP_M12_Human1.05131492
104GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05128864
105SPI1_23127762_ChIP-Seq_K562_Human1.05082754
106TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05033871
107CJUN_26792858_Chip-Seq_BT549_Human1.04941232
108SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04059785
109PU1_27457419_Chip-Seq_LIVER_Mouse1.02513385
110SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02315214
111XRN2_22483619_ChIP-Seq_HELA_Human1.01939836
112SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00926888
113* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.00285861
114P300_18555785_Chip-Seq_ESCs_Mouse1.00138821
115P53_22387025_ChIP-Seq_ESCs_Mouse0.99429343
116AHR_22903824_ChIP-Seq_MCF-7_Human0.98991286
117MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98889047
118SMAD4_21799915_ChIP-Seq_A2780_Human0.98670236
119EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98033209
120SALL4_18804426_ChIP-ChIP_XEN_Mouse0.97285773
121LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.97026144
122FOXO3_23340844_ChIP-Seq_DLD1_Human0.96812835
123GATA3_26560356_Chip-Seq_TH2_Human0.96665992
124LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96252498
125STAT3_18555785_Chip-Seq_ESCs_Mouse0.96246824
126HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96243429
127GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95627805
128TP53_16413492_ChIP-PET_HCT116_Human0.95461190
129KDM2B_26808549_Chip-Seq_REH_Human0.95219963
130SOX2_18555785_Chip-Seq_ESCs_Mouse0.94104411
131ETS1_20019798_ChIP-Seq_JURKAT_Human0.94060661
132CREB1_15753290_ChIP-ChIP_HEK293T_Human0.93643925
133ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93375004
134SRY_22984422_ChIP-ChIP_TESTIS_Rat0.92793591
135PIAS1_25552417_ChIP-Seq_VCAP_Human0.92228252
136GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92128810
137BCAT_22108803_ChIP-Seq_LS180_Human0.91241244
138FOXA1_21572438_ChIP-Seq_LNCaP_Human0.90975698
139SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90772060
140ARNT_22903824_ChIP-Seq_MCF-7_Human0.90653867
141ESR2_21235772_ChIP-Seq_MCF-7_Human0.90494916
142MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.90333240
143RUNX1_27457419_Chip-Seq_LIVER_Mouse0.88845059
144GATA2_19941826_ChIP-Seq_K562_Human0.88661894
145FOXM1_26456572_ChIP-Seq_MCF-7_Human0.88639232
146* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.88638774
147ER_23166858_ChIP-Seq_MCF-7_Human0.88133664
148GATA1_19941826_ChIP-Seq_K562_Human0.87787931
149ETS1_22383799_ChIP-Seq_G1ME_Mouse0.86865309
150ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.85423373
151GATA3_27048872_Chip-Seq_THYMUS_Human0.85413598
152CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85183953
153LXR_22292898_ChIP-Seq_THP-1_Human0.84899066
154RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.84404966
155KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.83525324
156TTF2_22483619_ChIP-Seq_HELA_Human0.82293287
157MAF_26560356_Chip-Seq_TH2_Human0.82283462
158KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.82145017
159TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81721955
160MYC_18358816_ChIP-ChIP_MESCs_Mouse0.81209262
161NCOR1_26117541_ChIP-Seq_K562_Human0.79908840
162GATA2_22383799_ChIP-Seq_G1ME_Mouse0.79908778
163YY1_22570637_ChIP-Seq_MALME-3M_Human0.79228118
164GATA1_19941827_ChIP-Seq_MEL_Mouse0.78860084
165UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.78852974
166SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77976598
167HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.77810549
168PU_27001747_Chip-Seq_BMDM_Mouse0.77425534

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.93807768
2MP0002796_impaired_skin_barrier3.74797225
3MP0002254_reproductive_system_inflammat3.67588375
4MP0003195_calcinosis3.11856777
5MP0003279_aneurysm2.86308069
6MP0002060_abnormal_skin_morphology2.59615952
7MP0009379_abnormal_foot_pigmentation2.56275718
8MP0000465_gastrointestinal_hemorrhage2.54898091
9MP0000383_abnormal_hair_follicle2.46620793
10MP0005275_abnormal_skin_tensile2.39796114
11MP0009785_altered_susceptibility_to2.36514108
12MP0002166_altered_tumor_susceptibility2.31817796
13MP0001835_abnormal_antigen_presentation2.30745064
14MP0000569_abnormal_digit_pigmentation2.27636215
15MP0008995_early_reproductive_senescence2.27574301
16MP0001542_abnormal_bone_strength2.27466784
17MP0003300_gastrointestinal_ulcer2.25876371
18MP0004381_abnormal_hair_follicle2.23187373
19MP0005501_abnormal_skin_physiology2.20584985
20MP0002998_abnormal_bone_remodeling2.18831070
21MP0000685_abnormal_immune_system2.18189121
22MP0001216_abnormal_epidermal_layer2.10614466
23MP0003191_abnormal_cellular_cholesterol2.08248908
24MP0010234_abnormal_vibrissa_follicle2.02179981
25MP0002877_abnormal_melanocyte_morpholog2.01596005
26MP0005647_abnormal_sex_gland1.99771145
27MP0000604_amyloidosis1.98237977
28MP0008004_abnormal_stomach_pH1.93813449
29MP0003941_abnormal_skin_development1.93085967
30MP0001545_abnormal_hematopoietic_system1.93050462
31MP0005397_hematopoietic_system_phenotyp1.93050462
32MP0003724_increased_susceptibility_to1.92247680
33MP0002009_preneoplasia1.88275667
34MP0005025_abnormal_response_to1.84773630
35MP0002006_tumorigenesis1.84483900
36MP0006082_CNS_inflammation1.84477631
37MP0010678_abnormal_skin_adnexa1.83211238
38MP0002148_abnormal_hypersensitivity_rea1.79299381
39MP0003866_abnormal_defecation1.78937190
40MP0003436_decreased_susceptibility_to1.77877674
41MP0005451_abnormal_body_composition1.75279958
42MP0005464_abnormal_platelet_physiology1.73529685
43MP0008007_abnormal_cellular_replicative1.72029257
44MP0002095_abnormal_skin_pigmentation1.71733897
45MP0005166_decreased_susceptibility_to1.67745565
46MP0005174_abnormal_tail_pigmentation1.67107021
47MP0010771_integument_phenotype1.64535487
48MP0004808_abnormal_hematopoietic_stem1.64067264
49MP0004947_skin_inflammation1.62625051
50MP0001800_abnormal_humoral_immune1.61210587
51MP0003453_abnormal_keratinocyte_physiol1.56927929
52MP0003763_abnormal_thymus_physiology1.56791128
53MP0005671_abnormal_response_to1.56621520
54MP0002419_abnormal_innate_immunity1.55518402
55MP0002452_abnormal_antigen_presenting1.53489330
56MP0000920_abnormal_myelination1.50465317
57MP0002723_abnormal_immune_serum1.48070270
58MP0003890_abnormal_embryonic-extraembry1.47625037
59MP0005000_abnormal_immune_tolerance1.47269098
60MP0001851_eye_inflammation1.44688045
61MP0002420_abnormal_adaptive_immunity1.43710005
62MP0001819_abnormal_immune_cell1.42144177
63MP0005023_abnormal_wound_healing1.41519706
64MP0003183_abnormal_peptide_metabolism1.40628007
65MP0003786_premature_aging1.40609053
66MP0001853_heart_inflammation1.38534835
67MP0003693_abnormal_embryo_hatching1.37149802
68MP0000647_abnormal_sebaceous_gland1.36409747
69MP0000467_abnormal_esophagus_morphology1.34767290
70MP0002398_abnormal_bone_marrow1.34421001
71MP0003075_altered_response_to1.31354540
72MP0000490_abnormal_crypts_of1.31187154
73MP0000377_abnormal_hair_follicle1.29689856
74MP0003828_pulmonary_edema1.29312048
75MP0005390_skeleton_phenotype1.29128464
76MP0009931_abnormal_skin_appearance1.28340967
77MP0009840_abnormal_foam_cell1.26114879
78MP0009278_abnormal_bone_marrow1.23771435
79MP0000858_altered_metastatic_potential1.21687370
80MP0000343_altered_response_to1.21612519
81MP0002277_abnormal_respiratory_mucosa1.20268595
82MP0001191_abnormal_skin_condition1.19458955
83MP0010155_abnormal_intestine_physiology1.17945409
84MP0003091_abnormal_cell_migration1.16402579
85MP0003795_abnormal_bone_structure1.14500547
86MP0005310_abnormal_salivary_gland1.14201941
87MP0010352_gastrointestinal_tract_polyps1.13485581
88MP0004185_abnormal_adipocyte_glucose1.12882937
89MP0010307_abnormal_tumor_latency1.11918637
90MP0005164_abnormal_response_to1.10623903
91MP0000689_abnormal_spleen_morphology1.10492799
92MP0002138_abnormal_hepatobiliary_system1.10314551
93MP0002722_abnormal_immune_system1.09942957
94MP0000716_abnormal_immune_system1.09426313
95MP0003045_fibrosis1.08560146
96MP0005645_abnormal_hypothalamus_physiol1.08297418
97MP0000015_abnormal_ear_pigmentation1.07531103
98MP0005058_abnormal_lysosome_morphology1.07167105
99MP0005365_abnormal_bile_salt1.06567218
100MP0002098_abnormal_vibrissa_morphology1.05111581
101MP0008875_abnormal_xenobiotic_pharmacok1.04786615
102MP0001845_abnormal_inflammatory_respons1.04116519
103MP0008961_abnormal_basal_metabolism1.01171802
104MP0002429_abnormal_blood_cell1.00626863
105MP0002896_abnormal_bone_mineralization0.98337144
106MP0004782_abnormal_surfactant_physiolog0.95305515
107MP0005075_abnormal_melanosome_morpholog0.94410760
108MP0008874_decreased_physiological_sensi0.93862239
109MP0009115_abnormal_fat_cell0.93735117
110MP0002405_respiratory_system_inflammati0.93696534
111MP0000367_abnormal_coat/_hair0.93526767
112MP0003252_abnormal_bile_duct0.93488081
113MP0005409_darkened_coat_color0.93464857
114MP0003172_abnormal_lysosome_physiology0.93014055
115MP0006054_spinal_hemorrhage0.92085859
116MP0009764_decreased_sensitivity_to0.92024391
117MP0001790_abnormal_immune_system0.90338759
118MP0005387_immune_system_phenotype0.90338759
119MP0009333_abnormal_splenocyte_physiolog0.88021102
120MP0005167_abnormal_blood-brain_barrier0.87670090
121MP0003656_abnormal_erythrocyte_physiolo0.86118556
122MP0003566_abnormal_cell_adhesion0.85708202
123MP0003303_peritoneal_inflammation0.84559654
124MP0001873_stomach_inflammation0.83047313
125MP0000427_abnormal_hair_cycle0.80345704
126MP0002933_joint_inflammation0.79957034
127MP0008469_abnormal_protein_level0.79599635
128MP0001533_abnormal_skeleton_physiology0.76851943
129MP0000703_abnormal_thymus_morphology0.76634471
130MP0002019_abnormal_tumor_incidence0.76629445
131MP0003448_altered_tumor_morphology0.75916836
132MP0009697_abnormal_copulation0.75295980
133MP0003638_abnormal_response/metabolism_0.73935624
134MP0004147_increased_porphyrin_level0.73428736
135MP0000249_abnormal_blood_vessel0.72460129
136MP0009763_increased_sensitivity_to0.72447336
137MP0001849_ear_inflammation0.72403968
138MP0005666_abnormal_adipose_tissue0.72382768
139MP0005165_increased_susceptibility_to0.70129409
140MP0009765_abnormal_xenobiotic_induced0.69558559

Predicted human phenotypes

RankGene SetZ-score
1Small epiphyses (HP:0010585)6.57683256
2Metaphyseal cupping (HP:0003021)6.27714361
3Vacuolated lymphocytes (HP:0001922)5.49060322
4Irregular vertebral endplates (HP:0003301)5.48585639
5Abnormality of cells of the erythroid lineage (HP:0012130)5.35926463
6Chronic otitis media (HP:0000389)4.87381359
7Abnormal number of erythroid precursors (HP:0012131)4.50186801
8Ulnar bowing (HP:0003031)4.45067835
9Gonadotropin excess (HP:0000837)4.38677658
10Flared iliac wings (HP:0002869)4.33464395
11Cupped ribs (HP:0000887)4.31005931
12Systemic lupus erythematosus (HP:0002725)4.26287123
13Reticulocytopenia (HP:0001896)4.25302949
14Abnormality of the vertebral endplates (HP:0005106)4.21784866
15Osteolytic defects of the hand bones (HP:0009699)4.20936323
16Osteolytic defects of the phalanges of the hand (HP:0009771)4.20936323
17Fragile nails (HP:0001808)4.17479222
18Thrombocytosis (HP:0001894)4.13733886
19Spondylolisthesis (HP:0003302)4.11301075
20Acute lymphatic leukemia (HP:0006721)4.10041611
21Tibial bowing (HP:0002982)4.04746812
22Plantar hyperkeratosis (HP:0007556)4.02685777
23Flattened epiphyses (HP:0003071)3.94889175
24Polygenic inheritance (HP:0010982)3.91656747
25Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.88547375
26Femoral bowing (HP:0002980)3.88493992
27Radial bowing (HP:0002986)3.74322721
28Papilledema (HP:0001085)3.62423201
29Onycholysis (HP:0001806)3.62133580
30IgM deficiency (HP:0002850)3.59224512
31Absent frontal sinuses (HP:0002688)3.57792907
32Abnormality of the frontal sinuses (HP:0002687)3.56051094
33Eczematoid dermatitis (HP:0000976)3.51050084
34Macrocytic anemia (HP:0001972)3.49635661
35Milia (HP:0001056)3.47604275
36Elevated erythrocyte sedimentation rate (HP:0003565)3.44453577
37Disinhibition (HP:0000734)3.41479347
38Autoimmune thrombocytopenia (HP:0001973)3.37344756
39Aplasia/Hypoplasia involving the sinuses (HP:0009120)3.36026965
40Bilateral sensorineural hearing impairment (HP:0008619)3.33609695
41Cellulitis (HP:0100658)3.33369379
42Increased cerebral lipofuscin (HP:0011813)3.25495451
43Abnormal hemoglobin (HP:0011902)3.23943122
44Abnormality of liposaccharide metabolism (HP:0010968)3.23445027
45Abnormality of glycosphingolipid metabolism (HP:0004343)3.23445027
46Abnormality of glycolipid metabolism (HP:0010969)3.23445027
47Persistence of primary teeth (HP:0006335)3.22911361
48Orchitis (HP:0100796)3.08842134
49Myositis (HP:0100614)3.05145988
50Acute myeloid leukemia (HP:0004808)3.04604756
51Increased neuronal autofluorescent lipopigment (HP:0002074)3.04189628
52Erythema (HP:0010783)3.00798608
53Nausea (HP:0002018)2.99006319
54Palmoplantar hyperkeratosis (HP:0000972)2.97587396
55Woolly hair (HP:0002224)2.90846800
56Abnormal blistering of the skin (HP:0008066)2.89799095
57Hypotrichosis (HP:0001006)2.84433255
58Abnormality of the axillary hair (HP:0100134)2.80981650
59Abnormality of secondary sexual hair (HP:0009888)2.80981650
60Palmar hyperkeratosis (HP:0010765)2.80077242
61Recurrent cutaneous fungal infections (HP:0011370)2.78186174
62Chronic mucocutaneous candidiasis (HP:0002728)2.78186174
63Pallor (HP:0000980)2.74794544
64Metaphyseal irregularity (HP:0003025)2.74059948
65Recurrent skin infections (HP:0001581)2.70619542
66Gingivitis (HP:0000230)2.67095330
67Lip pit (HP:0100267)2.64665506
68Petechiae (HP:0000967)2.62771784
69Syringomyelia (HP:0003396)2.62032335
70Spinal cord lesions (HP:0100561)2.62032335
71Thick nail (HP:0001805)2.60829389
72Recurrent gram-negative bacterial infections (HP:0005420)2.58989924
73Skin ulcer (HP:0200042)2.58097930
74Blepharitis (HP:0000498)2.55796222
75Sepsis (HP:0100806)2.55737221
76Bone pain (HP:0002653)2.54078628
77Abnormality of macrophages (HP:0004311)2.51575695
78Inappropriate behavior (HP:0000719)2.49931630
79Pili torti (HP:0003777)2.48697082
80Recurrent bacterial skin infections (HP:0005406)2.45881838
81Coxa vara (HP:0002812)2.43492564
82Increased IgE level (HP:0003212)2.40519815
83Ectropion (HP:0000656)2.39787756
84Recurrent abscess formation (HP:0002722)2.37478776
85T lymphocytopenia (HP:0005403)2.37322218
86Tubulointerstitial fibrosis (HP:0005576)2.35353277
87Atrophic scars (HP:0001075)2.35325993
88Meningitis (HP:0001287)2.34730504
89Septate vagina (HP:0001153)2.32926484
90Abnormal delayed hypersensitivity skin test (HP:0002963)2.32814368
91Abnormality of the prostate (HP:0008775)2.32136285
92Tinnitus (HP:0000360)2.32040395
93Prominent nose (HP:0000448)2.31760212
94Bowing of the arm (HP:0006488)2.31334071
95Bowed forearm bones (HP:0003956)2.31334071
96Recurrent bronchitis (HP:0002837)2.31014466
97Obstructive lung disease (HP:0006536)2.29648426
98Chronic obstructive pulmonary disease (HP:0006510)2.29648426
99Nasal polyposis (HP:0100582)2.27503952
100Spontaneous hematomas (HP:0007420)2.26166945
101Premature loss of primary teeth (HP:0006323)2.25722831
102Interstitial pulmonary disease (HP:0006530)2.23567850
103Flared metaphyses (HP:0003015)2.23181786
104Mediastinal lymphadenopathy (HP:0100721)2.22655053
105Abnormality of T cell number (HP:0011839)2.21840337
106Secondary amenorrhea (HP:0000869)2.20157228
107Optic neuritis (HP:0100653)2.19781455
108Retrobulbar optic neuritis (HP:0100654)2.19781455
109Dysostosis multiplex (HP:0000943)2.19369487
110Chronic sinusitis (HP:0011109)2.19219265
111Nail dystrophy (HP:0008404)2.18832942
112Flat occiput (HP:0005469)2.18618264
113Loss of speech (HP:0002371)2.17449089
114Abnormality of homocysteine metabolism (HP:0010919)2.16252280
115Homocystinuria (HP:0002156)2.16252280
116Purpura (HP:0000979)2.15626801
117Urticaria (HP:0001025)2.14562448
118Multiple lipomas (HP:0001012)2.11654416
119Entropion (HP:0000621)2.11595339
120Abnormality of T cell physiology (HP:0011840)2.11136390
121Gangrene (HP:0100758)2.10702801
122Abnormality of the nasal mucosa (HP:0000433)2.08866531
123Protuberant abdomen (HP:0001538)2.07940861
124Mutism (HP:0002300)2.07365022
125Pulmonary fibrosis (HP:0002206)2.05386074
126Prolonged bleeding time (HP:0003010)2.00806111
127Ridged nail (HP:0001807)2.00165931
128Genu varum (HP:0002970)1.98783192
129Steatorrhea (HP:0002570)1.98483901
130Ureteral stenosis (HP:0000071)1.97773971
131Limited elbow extension (HP:0001377)1.95499260
132Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.94988731
133Recurrent fungal infections (HP:0002841)1.93346004
134Delayed closure of the anterior fontanelle (HP:0001476)1.92833627
135Abnormality of proline metabolism (HP:0010907)1.92675932
136Hydroxyprolinuria (HP:0003080)1.92675932
137Skin rash (HP:0000988)1.92376339
138Amyloidosis (HP:0011034)1.92057350
139Epistaxis (HP:0000421)1.90891674
140Glomerulonephritis (HP:0000099)1.90809285
141Esophageal varix (HP:0002040)1.90246781
142Gastrointestinal infarctions (HP:0005244)1.89514292
143Chest pain (HP:0100749)1.89303396
144Osteomyelitis (HP:0002754)1.88373619
145Hyperventilation (HP:0002883)1.86951871
146Inflammation of the large intestine (HP:0002037)1.86545168
147Multifactorial inheritance (HP:0001426)1.86490726
148Recurrent viral infections (HP:0004429)1.85302368
149Agammaglobulinemia (HP:0004432)1.85227641
150Tetraparesis (HP:0002273)1.84855412
151Areflexia of lower limbs (HP:0002522)1.84105153
152Abnormality of the common coagulation pathway (HP:0010990)1.83750385
153Recurrent pneumonia (HP:0006532)1.83286380
154Multiple enchondromatosis (HP:0005701)1.82933900
155Birth length less than 3rd percentile (HP:0003561)1.82838225
156Urinary glycosaminoglycan excretion (HP:0003541)1.82262252
157Mucopolysacchariduria (HP:0008155)1.82262252
158Ureteral obstruction (HP:0006000)1.82248821
159Arterial thrombosis (HP:0004420)1.81551906
160Sparse eyelashes (HP:0000653)1.81527547
161Alopecia of scalp (HP:0002293)1.80118617
162Narrow palate (HP:0000189)1.79779809
163Impaired platelet aggregation (HP:0003540)1.79093031
164Abnormal platelet function (HP:0011869)1.79093031
165Gastrointestinal stroma tumor (HP:0100723)1.78934286
166Hemoptysis (HP:0002105)1.78254784
167Fragile skin (HP:0001030)1.77516587
168Testicular atrophy (HP:0000029)1.77298888
169Progressive visual loss (HP:0000529)1.74569741
170Enlarged epiphyses (HP:0010580)1.74534806
171Keratoconjunctivitis sicca (HP:0001097)1.74266540
172Cheilitis (HP:0100825)1.73794391
173Restrictive lung disease (HP:0002091)1.73524388
174Congenital sensorineural hearing impairment (HP:0008527)1.73016614
175Vasculitis (HP:0002633)1.72754659
176Pulmonary infiltrates (HP:0002113)1.72461958
177Proximal placement of thumb (HP:0009623)1.72311784
178Peritonitis (HP:0002586)1.71427005
179Migraine (HP:0002076)1.71106680
180Stenosis of the external auditory canal (HP:0000402)1.70096996
181Congenital, generalized hypertrichosis (HP:0004540)1.69312896

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FLT37.42172739
2KIT5.26658150
3CSF1R3.35218280
4MAP3K133.17029035
5ACVR1B2.88879682
6NEK92.74791752
7MAP4K12.68970453
8NME22.58512170
9MST1R2.33500544
10TGFBR12.23362651
11MAP3K31.96461685
12IRAK41.96372270
13SRPK11.92573155
14STK241.90887943
15ARAF1.84547893
16EEF2K1.79659142
17BLK1.79265036
18MAP2K31.78492064
19CAMK1D1.71458716
20LRRK21.67741206
21ZAP701.67602834
22ERN11.66598796
23MAPKAPK31.63909498
24MAP3K61.56710926
25FRK1.54963451
26MAP3K141.52292906
27CAMK1G1.52196600
28PDK21.51269459
29MKNK11.46804418
30MAP2K61.46249982
31RPS6KB21.44478120
32MAP3K91.44154124
33BTK1.43868491
34CSK1.41838506
35TXK1.40040376
36BMPR1B1.29005853
37EIF2AK31.26254187
38CDC42BPA1.24413509
39EPHA31.21847258
40WEE11.21703472
41TBK11.21300974
42STK101.20162242
43MAP3K21.16994367
44BRSK21.16965981
45MAPKAPK51.15882232
46FES1.14910216
47TYK21.14691290
48SYK1.14576752
49GRK71.13626098
50YES11.11752833
51TEC1.08475154
52TGFBR21.07848372
53CASK1.06382171
54SGK21.03238435
55FGR1.02176411
56CDK191.00587845
57CAMKK20.96342119
58OXSR10.95723602
59TNIK0.94502323
60IKBKE0.93942862
61LCK0.91538483
62IRAK10.89570518
63PTK2B0.89264889
64TNK20.87939767
65ADRBK20.87362593
66IKBKB0.87123725
67PRKCQ0.82546935
68MAPK40.81286796
69MAP3K80.79938095
70RIPK40.76321085
71PDK10.74922675
72SCYL20.74615632
73EIF2AK20.70049836
74FER0.69594356
75DAPK20.69584663
76IGF1R0.69582013
77HCK0.68296637
78PIK3CA0.68123445
79RPS6KA20.67664024
80PDPK10.67378574
81TRPM70.65847922
82PRPF4B0.65187637
83CDK60.64999310
84MET0.64859211
85JAK30.64682150
86KSR20.64026757
87PDGFRB0.62748122
88TIE10.62338979
89TSSK60.60723392
90MKNK20.59666683
91SGK30.59019731
92PIM10.58737200
93MAP3K50.55875452
94TRIB30.55582101
95CDK120.54399603
96LYN0.54374880
97BCR0.53621686
98EGFR0.51331613
99ITK0.51028684
100IRAK30.50231984
101RPS6KA60.49703600
102FGFR40.49140965
103MOS0.48117738
104MAP3K40.45945197
105JAK20.45933918
106MAP2K40.45779664
107DYRK30.45540041
108SGK10.44403249
109CDK70.44335172
110SGK4940.43358518
111SGK2230.43358518
112MARK30.42900037
113STK110.42844773
114INSRR0.41975395
115MAP3K110.38839979
116ZAK0.38620555
117FGFR30.38421964
118MAP2K70.38384659
119RPS6KL10.37925985
120RPS6KC10.37925985
121TTN0.37863925
122ERBB20.37383423
123PIK3CG0.35890345
124PKN20.35771313
125RIPK10.35675060
126GRK60.35168768
127EPHB10.34568681
128MAPK110.33740306
129ALK0.33497016
130ILK0.33260087
131MAPK70.32652614
132CCNB10.32428431
133PASK0.32344550
134MAP3K100.32026119
135MAPKAPK20.31461250
136RET0.30852404
137TLK10.30645882
138HIPK20.30454036
139JAK10.29696045
140MAP2K20.29353815
141PTK60.28236813
142CLK10.27970744
143ABL20.26990237
144STK30.26907409
145TESK10.24866034
146TAOK30.24826708
147MAPK120.24575742
148ABL10.24120763
149MATK0.23583690
150MAP3K10.22499537
151GRK10.22443342

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.97788058
2Asthma_Homo sapiens_hsa053104.17765425
3Cyanoamino acid metabolism_Homo sapiens_hsa004604.11977742
4Allograft rejection_Homo sapiens_hsa053303.38851977
5Autoimmune thyroid disease_Homo sapiens_hsa053203.19476887
6Graft-versus-host disease_Homo sapiens_hsa053323.06419690
7Leishmaniasis_Homo sapiens_hsa051402.65011341
8Rheumatoid arthritis_Homo sapiens_hsa053232.59410201
9Type I diabetes mellitus_Homo sapiens_hsa049402.49892422
10Lysosome_Homo sapiens_hsa041422.11964469
11Acute myeloid leukemia_Homo sapiens_hsa052212.05449652
12B cell receptor signaling pathway_Homo sapiens_hsa046622.05148028
13Hematopoietic cell lineage_Homo sapiens_hsa046402.04455160
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.01724007
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.98135097
16Viral myocarditis_Homo sapiens_hsa054161.97282944
17Osteoclast differentiation_Homo sapiens_hsa043801.88706249
18Transcriptional misregulation in cancer_Homo sapiens_hsa052021.86677095
19Pentose phosphate pathway_Homo sapiens_hsa000301.82526518
20Phagosome_Homo sapiens_hsa041451.75466704
21Caffeine metabolism_Homo sapiens_hsa002321.72219331
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.59976258
23Leukocyte transendothelial migration_Homo sapiens_hsa046701.57395396
24DNA replication_Homo sapiens_hsa030301.55121157
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.53395743
26Herpes simplex infection_Homo sapiens_hsa051681.52222886
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.48334859
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.43962730
29Legionellosis_Homo sapiens_hsa051341.39003312
30Platelet activation_Homo sapiens_hsa046111.37131626
31Antigen processing and presentation_Homo sapiens_hsa046121.36783405
32Primary immunodeficiency_Homo sapiens_hsa053401.36030295
33Staphylococcus aureus infection_Homo sapiens_hsa051501.33308707
34Toxoplasmosis_Homo sapiens_hsa051451.29864772
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27001232
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.25955913
37Fatty acid elongation_Homo sapiens_hsa000621.25453457
38Collecting duct acid secretion_Homo sapiens_hsa049661.19279484
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.14821376
40Pertussis_Homo sapiens_hsa051331.13574218
41p53 signaling pathway_Homo sapiens_hsa041151.12050671
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.11349128
43Arachidonic acid metabolism_Homo sapiens_hsa005901.11296537
44* Jak-STAT signaling pathway_Homo sapiens_hsa046301.10898250
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.10403260
46Carbohydrate digestion and absorption_Homo sapiens_hsa049731.08053011
47Toll-like receptor signaling pathway_Homo sapiens_hsa046201.07566340
48Circadian rhythm_Homo sapiens_hsa047101.07149392
49Spliceosome_Homo sapiens_hsa030401.05806105
50Sulfur metabolism_Homo sapiens_hsa009201.05622568
51Chemokine signaling pathway_Homo sapiens_hsa040621.03492126
52Central carbon metabolism in cancer_Homo sapiens_hsa052300.97401541
53Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.96882486
54Influenza A_Homo sapiens_hsa051640.96425619
55VEGF signaling pathway_Homo sapiens_hsa043700.95624473
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.94483504
57Measles_Homo sapiens_hsa051620.94201931
58Glutathione metabolism_Homo sapiens_hsa004800.92026665
59* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89750578
60Renin-angiotensin system_Homo sapiens_hsa046140.89724986
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88024225
62Shigellosis_Homo sapiens_hsa051310.87255445
63Amoebiasis_Homo sapiens_hsa051460.85047090
64Sphingolipid metabolism_Homo sapiens_hsa006000.84483503
65Thyroid cancer_Homo sapiens_hsa052160.83579238
66Prolactin signaling pathway_Homo sapiens_hsa049170.80574163
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79269285
68Proteasome_Homo sapiens_hsa030500.78707876
69Proteoglycans in cancer_Homo sapiens_hsa052050.77526909
70Malaria_Homo sapiens_hsa051440.75212723
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72935415
72T cell receptor signaling pathway_Homo sapiens_hsa046600.72787819
73HTLV-I infection_Homo sapiens_hsa051660.72387908
74RNA polymerase_Homo sapiens_hsa030200.71603499
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.69503406
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69466395
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.68892702
78African trypanosomiasis_Homo sapiens_hsa051430.68290244
79Apoptosis_Homo sapiens_hsa042100.67862875
80Basal cell carcinoma_Homo sapiens_hsa052170.66193700
81Ether lipid metabolism_Homo sapiens_hsa005650.64705276
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64309579
83Systemic lupus erythematosus_Homo sapiens_hsa053220.63904649
84Hepatitis C_Homo sapiens_hsa051600.63718202
85Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.62474592
86Dorso-ventral axis formation_Homo sapiens_hsa043200.61125408
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61007989
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.60406404
89ABC transporters_Homo sapiens_hsa020100.60075183
90Linoleic acid metabolism_Homo sapiens_hsa005910.59439401
91MicroRNAs in cancer_Homo sapiens_hsa052060.59421222
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58955210
93Complement and coagulation cascades_Homo sapiens_hsa046100.58282632
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58191608
95Small cell lung cancer_Homo sapiens_hsa052220.57167346
96Insulin resistance_Homo sapiens_hsa049310.57084734
97Salmonella infection_Homo sapiens_hsa051320.56319676
98Intestinal immune network for IgA production_Homo sapiens_hsa046720.56287331
99Folate biosynthesis_Homo sapiens_hsa007900.55004244
100Vitamin B6 metabolism_Homo sapiens_hsa007500.54242726
101RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.54218576
102AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52154702
103Drug metabolism - other enzymes_Homo sapiens_hsa009830.51034603
104Notch signaling pathway_Homo sapiens_hsa043300.49946860
105Base excision repair_Homo sapiens_hsa034100.49849830
106Histidine metabolism_Homo sapiens_hsa003400.49238421
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48353782
108Pyrimidine metabolism_Homo sapiens_hsa002400.47816773
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47512745
110Ovarian steroidogenesis_Homo sapiens_hsa049130.47185294
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.46658406
112Tuberculosis_Homo sapiens_hsa051520.46388398
113Epstein-Barr virus infection_Homo sapiens_hsa051690.44608316
114Pathways in cancer_Homo sapiens_hsa052000.44185600
115Estrogen signaling pathway_Homo sapiens_hsa049150.43238745
116Pancreatic cancer_Homo sapiens_hsa052120.41893289
117Hedgehog signaling pathway_Homo sapiens_hsa043400.41336514
118Chronic myeloid leukemia_Homo sapiens_hsa052200.40630327
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.39793633
120Galactose metabolism_Homo sapiens_hsa000520.39698569
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39280797
122Mineral absorption_Homo sapiens_hsa049780.39148327
123Hepatitis B_Homo sapiens_hsa051610.37690587
124Fatty acid degradation_Homo sapiens_hsa000710.36996581
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36677258
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.35759300
127Other glycan degradation_Homo sapiens_hsa005110.35131070
128HIF-1 signaling pathway_Homo sapiens_hsa040660.34700613
129Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34134606
130Cell cycle_Homo sapiens_hsa041100.34029072
131TNF signaling pathway_Homo sapiens_hsa046680.33921389
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33820011
133Type II diabetes mellitus_Homo sapiens_hsa049300.33389892
134Inositol phosphate metabolism_Homo sapiens_hsa005620.33377515
135Renal cell carcinoma_Homo sapiens_hsa052110.32454388
136PPAR signaling pathway_Homo sapiens_hsa033200.31388058
137Choline metabolism in cancer_Homo sapiens_hsa052310.30651712
138Fatty acid biosynthesis_Homo sapiens_hsa000610.29505443
139Vibrio cholerae infection_Homo sapiens_hsa051100.28789036
140Vascular smooth muscle contraction_Homo sapiens_hsa042700.21766400
141Starch and sucrose metabolism_Homo sapiens_hsa005000.20227277
142Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19373180

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