IL22RA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)9.16596790
2angiotensin maturation (GO:0002003)6.72742723
3triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.28509678
4phospholipid efflux (GO:0033700)5.62406628
5desmosome organization (GO:0002934)5.56075607
6regulation of cholesterol esterification (GO:0010872)5.32629370
7regulation of triglyceride catabolic process (GO:0010896)5.21727367
8drug catabolic process (GO:0042737)5.12218400
9plasma lipoprotein particle assembly (GO:0034377)5.04440606
10NADH metabolic process (GO:0006734)5.03789099
11regulation of guanylate cyclase activity (GO:0031282)4.99839045
12regulation of bile acid biosynthetic process (GO:0070857)4.94224488
13fat-soluble vitamin biosynthetic process (GO:0042362)4.90531658
14flavonoid metabolic process (GO:0009812)4.87170605
15positive regulation of lipoprotein lipase activity (GO:0051006)4.83036344
16positive regulation of triglyceride lipase activity (GO:0061365)4.83036344
17cobalamin metabolic process (GO:0009235)4.81845469
18regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.81798166
19cholesterol efflux (GO:0033344)4.76784994
20protein-lipid complex assembly (GO:0065005)4.76129668
21lipoprotein metabolic process (GO:0042157)4.75950908
22reverse cholesterol transport (GO:0043691)4.73829373
23high-density lipoprotein particle remodeling (GO:0034375)4.73806227
24negative regulation of sterol transport (GO:0032372)4.62039338
25negative regulation of cholesterol transport (GO:0032375)4.62039338
26cysteine metabolic process (GO:0006534)4.61555401
27homocysteine metabolic process (GO:0050667)4.50913074
28cholesterol homeostasis (GO:0042632)4.43876077
29very-low-density lipoprotein particle assembly (GO:0034379)4.43732910
30vitamin A metabolic process (GO:0006776)4.43198603
31urea cycle (GO:0000050)4.41728411
32urea metabolic process (GO:0019627)4.41728411
33bile acid and bile salt transport (GO:0015721)4.40529233
34sterol homeostasis (GO:0055092)4.39367986
35bundle of His cell to Purkinje myocyte communication (GO:0086069)4.30666095
36plasma lipoprotein particle remodeling (GO:0034369)4.29170719
37protein-lipid complex remodeling (GO:0034368)4.29170719
38macromolecular complex remodeling (GO:0034367)4.29170719
39digestion (GO:0007586)4.28556701
40regulation of cholesterol homeostasis (GO:2000188)4.27469515
41sterol transport (GO:0015918)4.14427098
42cholesterol transport (GO:0030301)4.14427098
43establishment of skin barrier (GO:0061436)4.07296096
44L-phenylalanine catabolic process (GO:0006559)3.99625942
45erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.99625942
46nitrogen cycle metabolic process (GO:0071941)3.98585583
47fructose metabolic process (GO:0006000)3.97623550
48hormone catabolic process (GO:0042447)3.95522983
49digestive system process (GO:0022600)3.94948571
50regulation of water loss via skin (GO:0033561)3.92813789
51regulation of systemic arterial blood pressure by hormone (GO:0001990)3.92432451
52regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.92432451
53endocrine process (GO:0050886)3.92432451
54erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.91073922
55L-phenylalanine metabolic process (GO:0006558)3.91073922
56triglyceride homeostasis (GO:0070328)3.85753168
57acylglycerol homeostasis (GO:0055090)3.85753168
58keratinization (GO:0031424)3.81482678
59glycolipid catabolic process (GO:0019377)3.81155057
60adhesion of symbiont to host cell (GO:0044650)3.79269580
61virion attachment to host cell (GO:0019062)3.79269580
62transcytosis (GO:0045056)3.79051544
63multicellular organismal water homeostasis (GO:0050891)3.78972528
64sulfur amino acid catabolic process (GO:0000098)3.77649007
65phosphatidylserine acyl-chain remodeling (GO:0036150)3.72078517
66positive regulation of fatty acid biosynthetic process (GO:0045723)3.71460424
67phospholipid homeostasis (GO:0055091)3.67692628
68maintenance of gastrointestinal epithelium (GO:0030277)3.66813908
69plasma lipoprotein particle organization (GO:0071827)3.66169731
70positive regulation of guanylate cyclase activity (GO:0031284)3.65805298
71negative regulation of digestive system process (GO:0060457)3.61282244
72protein-lipid complex subunit organization (GO:0071825)3.58651823
73antimicrobial humoral response (GO:0019730)3.54074374
74renal system process involved in regulation of blood volume (GO:0001977)3.53801018
753-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.53284382
76purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.53284382
77regulation of systemic arterial blood pressure (GO:0003073)3.53238245
78plasma lipoprotein particle clearance (GO:0034381)3.52913739
79aromatic amino acid family catabolic process (GO:0009074)3.52758595
80modified amino acid transport (GO:0072337)3.49958853
81epoxygenase P450 pathway (GO:0019373)3.47672948
82fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.45217036
83ceramide catabolic process (GO:0046514)3.44590727
84lipoprotein transport (GO:0042953)3.44464290
85positive regulation of lipid catabolic process (GO:0050996)3.42888567
86glucose 6-phosphate metabolic process (GO:0051156)3.42845922
87antibacterial humoral response (GO:0019731)3.42689707
88UDP-N-acetylglucosamine metabolic process (GO:0006047)3.41276569
89adhesion of symbiont to host (GO:0044406)3.41053398
90positive regulation of triglyceride metabolic process (GO:0090208)3.39497019
91lipid homeostasis (GO:0055088)3.38949493
92lysine catabolic process (GO:0006554)3.38552713
93lysine metabolic process (GO:0006553)3.38552713
94membrane lipid catabolic process (GO:0046466)3.36528813
95intestinal epithelial cell development (GO:0060576)3.36426125
96bile acid metabolic process (GO:0008206)3.35942602
97alpha-linolenic acid metabolic process (GO:0036109)3.35273636
98phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.35256351
99exogenous drug catabolic process (GO:0042738)3.33414144
100kynurenine metabolic process (GO:0070189)3.27775388
101cellular glucuronidation (GO:0052695)3.27122818
102renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.24114004
103drug metabolic process (GO:0017144)3.22405293
104ethanol oxidation (GO:0006069)3.20094126
105diacylglycerol metabolic process (GO:0046339)3.20060125
106cellular modified amino acid catabolic process (GO:0042219)3.20031010
107vitamin transmembrane transport (GO:0035461)3.19990700
108indolalkylamine catabolic process (GO:0046218)3.18485481
109tryptophan catabolic process (GO:0006569)3.18485481
110indole-containing compound catabolic process (GO:0042436)3.18485481
111regulation of phospholipase A2 activity (GO:0032429)3.18078342
112phosphatidylinositol acyl-chain remodeling (GO:0036149)3.18023855
113peptide catabolic process (GO:0043171)3.17959053
114drug transmembrane transport (GO:0006855)3.17256142
115icosanoid transport (GO:0071715)3.16980521
116fatty acid derivative transport (GO:1901571)3.16980521
117actin filament depolymerization (GO:0030042)3.16091394
118water homeostasis (GO:0030104)3.15125587
119negative regulation of epidermal cell differentiation (GO:0045605)3.14371427
120amino-acid betaine metabolic process (GO:0006577)3.12078750
121positive regulation of pseudopodium assembly (GO:0031274)3.08784275
122drug transport (GO:0015893)3.07085079
123bile acid biosynthetic process (GO:0006699)3.05605182
124alkaloid metabolic process (GO:0009820)3.04322112
125glyoxylate metabolic process (GO:0046487)3.03362384
126tryptophan metabolic process (GO:0006568)3.01072002
127hemidesmosome assembly (GO:0031581)2.99216915
128sphingolipid catabolic process (GO:0030149)2.98341938
129arachidonic acid secretion (GO:0050482)2.97983490
130icosanoid secretion (GO:0032309)2.97983490
131heme transport (GO:0015886)2.97567046
132arginine metabolic process (GO:0006525)2.97172729
133regulation of sterol transport (GO:0032371)2.96236632
134regulation of cholesterol transport (GO:0032374)2.96236632
135calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.96217387
136regulation of cGMP biosynthetic process (GO:0030826)2.96212349
137regulation of cholesterol metabolic process (GO:0090181)2.96008084
138regulation of cellular extravasation (GO:0002691)2.95604160
139glucuronate metabolic process (GO:0019585)2.94314604
140uronic acid metabolic process (GO:0006063)2.94314604
141regulation of vitamin metabolic process (GO:0030656)2.93536867
142response to nitrosative stress (GO:0051409)2.92280859
143peptide hormone processing (GO:0016486)2.92267858
144proline metabolic process (GO:0006560)2.91966214
145glutamine family amino acid biosynthetic process (GO:0009084)2.91897165
146glutamate metabolic process (GO:0006536)2.91189965
147ethanol metabolic process (GO:0006067)2.88607411
148receptor guanylyl cyclase signaling pathway (GO:0007168)2.87835594
149regulation of keratinocyte differentiation (GO:0045616)2.83905570
150intestinal cholesterol absorption (GO:0030299)10.6021344

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.34312244
2TP63_17297297_ChIP-ChIP_HaCaT_Human6.42998147
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.29102110
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.99906260
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.60404216
6LXR_22158963_ChIP-Seq_LIVER_Mouse4.57985473
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.94778843
8CDX2_20551321_ChIP-Seq_CACO-2_Human3.69320960
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.17989935
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.15991124
11* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.92986333
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.91742620
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.75782548
14CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.64475865
15* GATA4_25053715_ChIP-Seq_YYC3_Human2.54945067
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.45542676
17* GATA6_25053715_ChIP-Seq_YYC3_Human2.15170275
18* SOX2_20726797_ChIP-Seq_SW620_Human1.88108925
19ESR2_21235772_ChIP-Seq_MCF-7_Human1.83169708
20PPAR_26484153_Chip-Seq_NCI-H1993_Human1.82853481
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.80897201
22CLOCK_20551151_ChIP-Seq_293T_Human1.74504493
23ESR1_21235772_ChIP-Seq_MCF-7_Human1.69676541
24TRIM28_21343339_ChIP-Seq_HEK293_Human1.69415455
25FOXA2_19822575_ChIP-Seq_HepG2_Human1.67571387
26FOXO3_23340844_ChIP-Seq_DLD1_Human1.60749719
27CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.59178593
28* HNF4A_19822575_ChIP-Seq_HepG2_Human1.51301661
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.39760424
30KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.36827978
31SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.33986412
32TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.32466579
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32254853
34KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29010167
35RUNX1_27514584_Chip-Seq_MCF-7_Human1.28579131
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.26818581
37CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26575305
38RACK7_27058665_Chip-Seq_MCF-7_Human1.26298970
39FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26260380
40GATA1_22025678_ChIP-Seq_K562_Human1.26049366
41ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22466219
42KLF5_25053715_ChIP-Seq_YYC3_Human1.21475661
43ESR1_20079471_ChIP-ChIP_T-47D_Human1.21115887
44ATF3_27146783_Chip-Seq_COLON_Human1.18352839
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.16585992
46ZNF263_19887448_ChIP-Seq_K562_Human1.16141637
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16079374
48CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.16004037
49BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15897240
50* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.15119050
51* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.14929395
52GATA2_19941826_ChIP-Seq_K562_Human1.13176440
53TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13020044
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.12345233
55NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.11789748
56ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11471958
57ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11451337
58HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10684068
59ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10429350
60JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.09977675
61* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.09565419
62SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09444011
63TCF4_18268006_ChIP-ChIP_LS174T_Human1.07262377
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.02506281
65NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.00740410
66UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00289635
67SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00027728
68* SA1_27219007_Chip-Seq_Bcells_Human0.99030396
69SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.98467054
70FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.98136296
71THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96773181
72P63_26484246_Chip-Seq_KERATINOCYTES_Human0.96148559
73DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95053031
74PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94229939
75SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93311360
76EGR1_19032775_ChIP-ChIP_M12_Human0.92715002
77BCL6_27268052_Chip-Seq_Bcells_Human0.92259596
78CREB1_26743006_Chip-Seq_LNCaP_Human0.92211977
79CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.91969904
80* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91243425
81PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91010281
82GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.90299163
83SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.89808086
84SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.89808086
85CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89425263
86Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.89218817
87GATA3_24758297_ChIP-Seq_MCF-7_Human0.88173699
88* LXR_22292898_ChIP-Seq_THP-1_Human0.86768873
89FOXA1_25552417_ChIP-Seq_VCAP_Human0.86438391
90SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86034499
91KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.84072372
92P68_20966046_ChIP-Seq_HELA_Human0.83285812
93MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.82514169
94SA1_27219007_Chip-Seq_ERYTHROID_Human0.81388636
95TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80938575
96* CEBPB_22108803_ChIP-Seq_LS180_Human0.80240128
97GATA1_19941826_ChIP-Seq_K562_Human0.80156381
98HTT_18923047_ChIP-ChIP_STHdh_Human0.79839484
99STAT6_21828071_ChIP-Seq_BEAS2B_Human0.79233909
100BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.79164805
101TP63_23658742_ChIP-Seq_EP156T_Human0.77627299
102* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72563301
103GATA2_21666600_ChIP-Seq_HMVEC_Human0.70669619
104AR_21909140_ChIP-Seq_LNCAP_Human0.70427327
105RARA_24833708_ChIP-Seq_LIVER_Mouse0.70077995
106CDX2_22108803_ChIP-Seq_LS180_Human0.68473887
107TP63_22573176_ChIP-Seq_HFKS_Human0.68400789
108SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.67493957
109CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.66770766
110FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.65819030
111CTCF_27219007_Chip-Seq_Bcells_Human0.65189188
112CTNNB1_20460455_ChIP-Seq_HCT116_Human0.65164106
113CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.64317065
114BCOR_27268052_Chip-Seq_Bcells_Human0.64156665
115FOXM1_26456572_ChIP-Seq_MCF-7_Human0.63635490
116NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.63493801
117* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.63219678
118EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.62400049

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.60399065
2MP0001666_abnormal_nutrient_absorption5.79309070
3MP0002139_abnormal_hepatobiliary_system5.50107109
4MP0005085_abnormal_gallbladder_physiolo5.07284825
5MP0005365_abnormal_bile_salt4.50005888
6MP0008875_abnormal_xenobiotic_pharmacok3.73567226
7MP0003252_abnormal_bile_duct3.57781346
8MP0009840_abnormal_foam_cell3.51049117
9MP0010234_abnormal_vibrissa_follicle3.46754224
10MP0010329_abnormal_lipoprotein_level3.08361379
11MP0004264_abnormal_extraembryonic_tissu2.83704683
12MP0003705_abnormal_hypodermis_morpholog2.34918872
13MP0005083_abnormal_biliary_tract2.30908971
14MP0005409_darkened_coat_color2.27405894
15MP0003806_abnormal_nucleotide_metabolis2.19935013
16MP0004019_abnormal_vitamin_homeostasis2.11551170
17MP0000566_synostosis2.06191304
18MP0003191_abnormal_cellular_cholesterol2.02969726
19MP0005084_abnormal_gallbladder_morpholo2.01834669
20MP0002796_impaired_skin_barrier1.93334434
21MP0000462_abnormal_digestive_system1.90748472
22MP0003183_abnormal_peptide_metabolism1.88195232
23MP0005332_abnormal_amino_acid1.86315171
24MP0003868_abnormal_feces_composition1.84420536
25MP0002118_abnormal_lipid_homeostasis1.59420672
26MP0002254_reproductive_system_inflammat1.57109163
27MP0000609_abnormal_liver_physiology1.54315697
28MP0003866_abnormal_defecation1.44664268
29MP0000537_abnormal_urethra_morphology1.35707686
30MP0004782_abnormal_surfactant_physiolog1.29540759
31MP0005451_abnormal_body_composition1.26197680
32MP0001664_abnormal_digestion1.24849326
33MP0009643_abnormal_urine_homeostasis1.24798094
34MP0000678_abnormal_parathyroid_gland1.20371341
35MP0000538_abnormal_urinary_bladder1.17892407
36MP0005501_abnormal_skin_physiology1.17133572
37MP0010678_abnormal_skin_adnexa1.16818680
38MP0005448_abnormal_energy_balance1.16794316
39MP0005319_abnormal_enzyme/_coenzyme1.15679713
40MP0005670_abnormal_white_adipose1.13413036
41MP0004147_increased_porphyrin_level1.11627189
42MP0005381_digestive/alimentary_phenotyp1.11385413
43MP0010352_gastrointestinal_tract_polyps1.09206204
44MP0001663_abnormal_digestive_system1.08531733
45MP0000579_abnormal_nail_morphology1.07512694
46MP0001873_stomach_inflammation1.07234387
47MP0001188_hyperpigmentation1.07104511
48MP0003283_abnormal_digestive_organ1.05183410
49MP0002138_abnormal_hepatobiliary_system1.04964546
50MP0002822_catalepsy1.04520411
51MP0009697_abnormal_copulation1.01105701
52MP0010155_abnormal_intestine_physiology1.00943518
53MP0003300_gastrointestinal_ulcer1.00882156
54MP0004947_skin_inflammation1.00260338
55MP0009379_abnormal_foot_pigmentation1.00188739
56MP0003879_abnormal_hair_cell0.97366827
57MP0005220_abnormal_exocrine_pancreas0.96758611
58MP0002098_abnormal_vibrissa_morphology0.96312003
59MP0000477_abnormal_intestine_morphology0.96055990
60MP0009384_cardiac_valve_regurgitation0.95267437
61MP0003453_abnormal_keratinocyte_physiol0.94481318
62MP0001764_abnormal_homeostasis0.92312748
63MP0009053_abnormal_anal_canal0.90987409
64MP0006054_spinal_hemorrhage0.90449117
65MP0004043_abnormal_pH_regulation0.88382258
66MP0000467_abnormal_esophagus_morphology0.87836957
67MP0001216_abnormal_epidermal_layer0.86930992
68MP0002876_abnormal_thyroid_physiology0.86483641
69MP0002060_abnormal_skin_morphology0.84727175
70MP0004858_abnormal_nervous_system0.84241172
71MP0001849_ear_inflammation0.82729386
72MP0005636_abnormal_mineral_homeostasis0.78819136
73MP0005584_abnormal_enzyme/coenzyme_acti0.78619171
74MP0001756_abnormal_urination0.76626610
75MP0003941_abnormal_skin_development0.76552623
76MP0005377_hearing/vestibular/ear_phenot0.75214347
77MP0003878_abnormal_ear_physiology0.75214347
78MP0009780_abnormal_chondrocyte_physiolo0.73561435
79MP0000427_abnormal_hair_cycle0.73117601
80MP0000598_abnormal_liver_morphology0.69661795
81MP0005666_abnormal_adipose_tissue0.68748463
82MP0000377_abnormal_hair_follicle0.68258023
83MP0000604_amyloidosis0.68074111
84MP0008004_abnormal_stomach_pH0.66896318
85MP0000490_abnormal_crypts_of0.66243792
86MP0002166_altered_tumor_susceptibility0.65028506
87MP0009642_abnormal_blood_homeostasis0.64250660
88MP0003638_abnormal_response/metabolism_0.63204603
89MP0003195_calcinosis0.62457006
90MP0005167_abnormal_blood-brain_barrier0.62084820
91MP0003566_abnormal_cell_adhesion0.61724869
92MP0005257_abnormal_intraocular_pressure0.60843630
93MP0002136_abnormal_kidney_physiology0.60481787
94MP0000465_gastrointestinal_hemorrhage0.60052020
95MP0002089_abnormal_postnatal_growth/wei0.59971426
96MP0001765_abnormal_ion_homeostasis0.59819356
97MP0000383_abnormal_hair_follicle0.59378869
98MP0009765_abnormal_xenobiotic_induced0.58372328
99MP0009115_abnormal_fat_cell0.58241116
100MP0010771_integument_phenotype0.57110573
101MP0008872_abnormal_physiological_respon0.55152813
102MP0005166_decreased_susceptibility_to0.55123327
103MP0009764_decreased_sensitivity_to0.53672315
104MP0005266_abnormal_metabolism0.52827610
105MP0000367_abnormal_coat/_hair0.52650002
106MP0005408_hypopigmentation0.52081259
107MP0001845_abnormal_inflammatory_respons0.52035493
108MP0003329_amyloid_beta_deposits0.51193920
109MP0002896_abnormal_bone_mineralization0.50787301
110MP0005058_abnormal_lysosome_morphology0.50703547
111MP0002078_abnormal_glucose_homeostasis0.49893803
112MP0003656_abnormal_erythrocyte_physiolo0.49591452
113MP0000858_altered_metastatic_potential0.49468049
114MP0003959_abnormal_lean_body0.49286859
115MP0001191_abnormal_skin_condition0.49012926
116MP0005275_abnormal_skin_tensile0.48579719
117MP0008469_abnormal_protein_level0.48440598
118MP0003953_abnormal_hormone_level0.48352990
119MP0000762_abnormal_tongue_morphology0.48317921
120MP0005376_homeostasis/metabolism_phenot0.48183527
121MP0005076_abnormal_cell_differentiation0.47970867
122MP0003718_maternal_effect0.47644985
123MP0000249_abnormal_blood_vessel0.47060180
124MP0005248_abnormal_Harderian_gland0.46912674
125MP0005023_abnormal_wound_healing0.46616415
126MP0009931_abnormal_skin_appearance0.46333024
127MP0004185_abnormal_adipocyte_glucose0.44295624
128MP0002971_abnormal_brown_adipose0.43816968
129MP0000470_abnormal_stomach_morphology0.43095507

Predicted human phenotypes

RankGene SetZ-score
1Hypobetalipoproteinemia (HP:0003563)7.18730451
2Abnormality of glutamine family amino acid metabolism (HP:0010902)6.36985153
3Intrahepatic cholestasis (HP:0001406)5.46920148
4Fat malabsorption (HP:0002630)5.41455383
5Acanthocytosis (HP:0001927)5.40515833
6Ileus (HP:0002595)5.38874634
7Abnormality of monocarboxylic acid metabolism (HP:0010996)5.21316823
8Xanthomatosis (HP:0000991)5.04928240
9Conjugated hyperbilirubinemia (HP:0002908)5.02448755
10Right ventricular cardiomyopathy (HP:0011663)4.82769552
11Hypolipoproteinemia (HP:0010981)4.80768738
12Malnutrition (HP:0004395)4.76871056
13Abnormality of proline metabolism (HP:0010907)4.23380032
14Hydroxyprolinuria (HP:0003080)4.23380032
15Systemic lupus erythematosus (HP:0002725)4.06918526
16Deep venous thrombosis (HP:0002625)4.06526398
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.05885785
18Hyperglycinuria (HP:0003108)4.00499041
19Epidermoid cyst (HP:0200040)3.93894666
20Abnormality of aromatic amino acid family metabolism (HP:0004338)3.81808156
21Abnormality of sulfur amino acid metabolism (HP:0004339)3.73428370
22Abnormality of aspartate family amino acid metabolism (HP:0010899)3.61204060
23Hyperactive renin-angiotensin system (HP:0000841)3.55360086
24Hypercholesterolemia (HP:0003124)3.51932603
25Hemorrhage of the eye (HP:0011885)3.51799528
26Abnormality of glycine metabolism (HP:0010895)3.35906172
27Abnormality of serine family amino acid metabolism (HP:0010894)3.35906172
28Poikilocytosis (HP:0004447)3.33573184
29Hyperammonemia (HP:0001987)3.27172160
30Palmoplantar hyperkeratosis (HP:0000972)3.19966175
31Autoimmune thrombocytopenia (HP:0001973)3.18457181
32Pigmentary retinal degeneration (HP:0001146)3.13991104
33Steatorrhea (HP:0002570)3.10517536
34Prolonged partial thromboplastin time (HP:0003645)3.08593907
35Abdominal distention (HP:0003270)3.06052294
36Abnormality of nail color (HP:0100643)3.00870509
37Abnormality of purine metabolism (HP:0004352)2.99404896
38Hypoalphalipoproteinemia (HP:0003233)2.99218543
39Palmar hyperkeratosis (HP:0010765)2.94528589
40Abnormality of the common coagulation pathway (HP:0010990)2.90623474
41Decreased circulating renin level (HP:0003351)2.88947222
42Glomerulonephritis (HP:0000099)2.82326339
43Abnormality of nucleobase metabolism (HP:0010932)2.76814696
44Hypoglycemic coma (HP:0001325)2.75562318
45Complement deficiency (HP:0004431)2.68713649
46Congenital ichthyosiform erythroderma (HP:0007431)2.68572168
47Abnormal hair laboratory examination (HP:0003328)2.68305277
48Hyperbilirubinemia (HP:0002904)2.60786669
49Cupped ribs (HP:0000887)2.59943484
50Thin bony cortex (HP:0002753)2.58732551
51Milia (HP:0001056)2.57107350
52Hyperlipoproteinemia (HP:0010980)2.56557374
53Wide cranial sutures (HP:0010537)2.54789917
54Esophageal varix (HP:0002040)2.53335824
55Ketosis (HP:0001946)2.51716682
56Abnormality of the intrinsic pathway (HP:0010989)2.48195494
57Metabolic acidosis (HP:0001942)2.48125398
58Alkalosis (HP:0001948)2.48073281
59Dehydration (HP:0001944)2.46015652
60Cholecystitis (HP:0001082)2.45446900
61Abnormal gallbladder physiology (HP:0012438)2.45446900
62Vascular calcification (HP:0004934)2.45088701
63Widely patent fontanelles and sutures (HP:0004492)2.44938877
64Potter facies (HP:0002009)2.43502067
65Facial shape deformation (HP:0011334)2.43502067
66Alopecia of scalp (HP:0002293)2.43231337
67Abnormality of renin-angiotensin system (HP:0000847)2.42604788
68Abnormality of urine glucose concentration (HP:0011016)2.39456832
69Glycosuria (HP:0003076)2.39456832
70Abnormality of vitamin metabolism (HP:0100508)2.38233413
71Chronic diarrhea (HP:0002028)2.33084908
72Late onset (HP:0003584)2.32242752
73Pancreatitis (HP:0001733)2.32060711
74Abnormality of pyrimidine metabolism (HP:0004353)2.31634297
75Abnormality of small intestinal villus morphology (HP:0011472)2.31480851
76Villous atrophy (HP:0011473)2.31480851
77Reticulocytosis (HP:0001923)2.31298900
78Increased IgE level (HP:0003212)2.30545360
79Exocrine pancreatic insufficiency (HP:0001738)2.29610152
80Increased mean platelet volume (HP:0011877)2.29554667
81Metabolic alkalosis (HP:0200114)2.28854851
82Nephrolithiasis (HP:0000787)2.28695293
83Skin nodule (HP:0200036)2.27914736
84Increased purine levels (HP:0004368)2.26245211
85Hyperuricemia (HP:0002149)2.26245211
86Plantar hyperkeratosis (HP:0007556)2.25251826
87Onycholysis (HP:0001806)2.22365905
88Nephritis (HP:0000123)2.21750401
89Autoimmune hemolytic anemia (HP:0001890)2.21592763
90Woolly hair (HP:0002224)2.21537556
91Ketoacidosis (HP:0001993)2.20750697
92Proximal tubulopathy (HP:0000114)2.20108766
93Hypotension (HP:0002615)2.19487896
94Hyperglycinemia (HP:0002154)2.19299318
95Cardiovascular calcification (HP:0011915)2.19043633
96Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.18610561
97Eczematoid dermatitis (HP:0000976)2.18088909
98Hypophosphatemia (HP:0002148)2.17436800
99Gout (HP:0001997)2.16794188
100Flat acetabular roof (HP:0003180)2.13282874
101Amyloidosis (HP:0011034)2.11546388
102Abnormal blistering of the skin (HP:0008066)2.11469835
103Gastrointestinal dysmotility (HP:0002579)2.09809265
104Hypotrichosis (HP:0001006)2.09188969
105Abnormality of carpal bone ossification (HP:0006257)2.08493858
106Fragile nails (HP:0001808)2.08471041
107Hepatocellular carcinoma (HP:0001402)2.06195740
108Confusion (HP:0001289)2.05524871
109Abnormal tarsal ossification (HP:0008369)2.05466962
110Myocardial infarction (HP:0001658)2.05234939
111Glomerulosclerosis (HP:0000096)2.04552317
112Congenital sensorineural hearing impairment (HP:0008527)2.03445841
113Abnormality of fatty-acid metabolism (HP:0004359)1.98716406
114Atrophic scars (HP:0001075)1.98145453
115Hyperparathyroidism (HP:0000843)1.98132618
116Abnormality of the vitamin B12 metabolism (HP:0004341)1.98103074
117Abnormality of complement system (HP:0005339)1.97248737
118Cholelithiasis (HP:0001081)1.96160869
119Axonal loss (HP:0003447)1.96088273
120Focal segmental glomerulosclerosis (HP:0000097)1.95879812
121Abnormality of methionine metabolism (HP:0010901)1.93937434
122Abnormal gallbladder morphology (HP:0012437)1.93536345
123Pili torti (HP:0003777)1.93378349
124Micronodular cirrhosis (HP:0001413)1.93165930
125Abnormal platelet volume (HP:0011876)1.92441012
126Abnormality of vitamin B metabolism (HP:0004340)1.92393962
127Abnormality of chloride homeostasis (HP:0011422)1.92087706
128Nausea (HP:0002018)1.91694416
129Pustule (HP:0200039)1.91526144
130Erythema (HP:0010783)1.91476416
131Thick nail (HP:0001805)1.89933407
132Subcapsular cataract (HP:0000523)1.89713208
133Rickets (HP:0002748)1.87746484
134Abnormality of the gastric mucosa (HP:0004295)1.87490625
135Megaloblastic anemia (HP:0001889)1.87413582
136Symptomatic seizures (HP:0011145)1.85933995
137Mesangial abnormality (HP:0001966)1.84752846
138Hypoglycemic seizures (HP:0002173)1.84138668
139Abnormality of the costochondral junction (HP:0000919)1.83637417
140Neonatal death (HP:0003811)1.83227772

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.37887040
2MST1R4.66681966
3MST44.41811607
4EPHA24.06922805
5ACVR1B3.60078608
6ERN13.35490628
7MAP2K22.88839943
8LMTK22.74054736
9RIPK12.54524452
10PTK62.47836368
11GRK62.41424810
12LATS12.34954467
13MAP3K102.28836089
14BCKDK2.23101216
15PRKG22.22026728
16NME12.15861677
17STK392.06733739
18MET1.89034735
19MAP3K21.80513650
20AKT31.77303888
21TAOK31.77018942
22EPHB21.64412113
23FGFR31.58978431
24STK241.53796106
25PKN21.52954125
26ERBB41.47935380
27FGFR41.46928630
28NUAK11.41973811
29TRIB31.36799585
30FER1.35851522
31PTK21.35214395
32MAP3K71.28444012
33MAP2K11.26861471
34STK101.18662406
35PRPF4B1.18573431
36MAP3K31.14215032
37EPHB11.09441815
38MAPK111.08688365
39ERBB21.06046917
40SIK11.05130603
41MAP3K121.04177375
42INSRR1.01335730
43WNK40.99144832
44PRKAA20.96660362
45PRKCI0.96328502
46BMX0.95006909
47PIK3CA0.92089902
48TESK10.90102089
49TAOK10.89027445
50IRAK10.87167418
51MAP2K60.85093649
52DDR20.84350856
53MAP3K80.80367178
54CDC42BPA0.78400823
55IRAK30.78229830
56MAP3K110.77680337
57OXSR10.73550113
58KSR20.72753867
59LRRK20.72226647
60PAK40.70585161
61SMG10.70219457
62DYRK1B0.68658547
63ICK0.66826285
64TBK10.66686416
65MAP3K10.62775485
66MATK0.61467826
67STK30.60716520
68PDK20.58989775
69CDK60.58643223
70TYK20.57256868
71PAK30.55280282
72PAK20.54562540
73EPHA30.50523418
74IRAK20.49166118
75PDPK10.48888949
76EPHA40.48768883
77TESK20.48614015
78PDGFRA0.48530756
79PRKAA10.48314192
80MAP3K60.47142318
81RET0.47131646
82GRK10.46424139
83MYLK0.44789553
84NLK0.43448593
85STK38L0.41795592
86MAP2K40.41560586
87SCYL20.40268121
88CSK0.38764918
89FGFR10.38405256
90RPS6KB20.38285807
91GSK3A0.37349266
92CAMK2G0.37157875
93PIM20.34717413
94EEF2K0.34698439
95PRKCZ0.34322254
96FLT30.33298605
97JAK20.32679221
98PIK3CG0.32292223
99PRKACG0.31164534
100MAPKAPK20.30385354
101CDK120.29758278
102AKT20.29457275
103NEK90.27534704
104MAP4K10.27040147
105SGK4940.26900982
106SGK2230.26900982
107MAPKAPK30.26076734
108TAOK20.25393801
109MAP3K90.25172870
110MTOR0.24914982
111IRAK40.24629792
112ZAP700.24557462
113SRC0.24043402
114PDK10.23255909
115PRKCA0.23125115
116CAMK1D0.22468982
117FGR0.21490480
118PDGFRB0.21488024
119TTK0.20596345
120CSF1R0.20409809
121PBK0.20057952
122JAK10.19923997
123MAP2K30.19856334
124TGFBR20.19727568
125PRKCD0.18585328
126FYN0.18584708
127MELK0.18369290
128RPS6KA20.18176368
129IGF1R0.18155223
130CAMK2D0.18151875
131PRKD20.17203853
132CSNK1A10.16205046
133PRKCQ0.15855853
134ABL20.15014604

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049754.87953989
2Vitamin digestion and absorption_Homo sapiens_hsa049773.12548511
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.05867853
4Caffeine metabolism_Homo sapiens_hsa002322.80340539
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.73306107
6Renin-angiotensin system_Homo sapiens_hsa046142.71110946
7Nitrogen metabolism_Homo sapiens_hsa009102.70599487
8Arginine biosynthesis_Homo sapiens_hsa002202.43321669
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.35893841
10Mineral absorption_Homo sapiens_hsa049782.34854941
11Starch and sucrose metabolism_Homo sapiens_hsa005002.29118229
12Tryptophan metabolism_Homo sapiens_hsa003802.17186399
13Sulfur metabolism_Homo sapiens_hsa009202.13125337
14Bile secretion_Homo sapiens_hsa049762.11285506
15Maturity onset diabetes of the young_Homo sapiens_hsa049502.06558014
16Histidine metabolism_Homo sapiens_hsa003402.06422182
17Folate biosynthesis_Homo sapiens_hsa007901.96024798
18Protein digestion and absorption_Homo sapiens_hsa049741.91004055
19Fatty acid degradation_Homo sapiens_hsa000711.86342533
20PPAR signaling pathway_Homo sapiens_hsa033201.79142710
21Galactose metabolism_Homo sapiens_hsa000521.71965721
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.67976005
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.66616228
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.66268123
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.65748550
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.58039388
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.56087804
28Carbohydrate digestion and absorption_Homo sapiens_hsa049731.55638797
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.49985919
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.45170897
31Glycerolipid metabolism_Homo sapiens_hsa005611.45153403
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.41140049
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.40651780
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.33714051
35Chemical carcinogenesis_Homo sapiens_hsa052041.28561895
36beta-Alanine metabolism_Homo sapiens_hsa004101.25081990
37Complement and coagulation cascades_Homo sapiens_hsa046101.22806199
38Fructose and mannose metabolism_Homo sapiens_hsa000511.22546918
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.20692787
40Glutathione metabolism_Homo sapiens_hsa004801.20270512
41ABC transporters_Homo sapiens_hsa020101.18741546
42Peroxisome_Homo sapiens_hsa041461.17434413
43Retinol metabolism_Homo sapiens_hsa008301.16442430
44Drug metabolism - other enzymes_Homo sapiens_hsa009831.16131164
45Butanoate metabolism_Homo sapiens_hsa006501.14303916
46Arginine and proline metabolism_Homo sapiens_hsa003301.12702745
47Pancreatic secretion_Homo sapiens_hsa049721.08968242
48Selenocompound metabolism_Homo sapiens_hsa004501.08170144
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.05511210
50Fatty acid metabolism_Homo sapiens_hsa012121.05345702
51Steroid biosynthesis_Homo sapiens_hsa001001.02401101
52Pyruvate metabolism_Homo sapiens_hsa006201.01985203
53Propanoate metabolism_Homo sapiens_hsa006401.00464219
54Carbon metabolism_Homo sapiens_hsa012000.94783955
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91977994
56Biosynthesis of amino acids_Homo sapiens_hsa012300.91667913
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.91378768
58Phenylalanine metabolism_Homo sapiens_hsa003600.90800208
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.88896835
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88741974
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77709110
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74183619
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70908754
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67988179
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65263711
66Pentose phosphate pathway_Homo sapiens_hsa000300.63670837
67Other glycan degradation_Homo sapiens_hsa005110.60031257
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.59743515
69Tyrosine metabolism_Homo sapiens_hsa003500.57483249
70Lysine degradation_Homo sapiens_hsa003100.56570092
71Staphylococcus aureus infection_Homo sapiens_hsa051500.54639441
72Fatty acid elongation_Homo sapiens_hsa000620.48562574
73Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48126413
74Linoleic acid metabolism_Homo sapiens_hsa005910.47452518
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.46622555
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44231521
77Sphingolipid metabolism_Homo sapiens_hsa006000.43433835
78Thyroid hormone synthesis_Homo sapiens_hsa049180.41213046
79Fatty acid biosynthesis_Homo sapiens_hsa000610.40947964
80Metabolic pathways_Homo sapiens_hsa011000.34730539
81Tight junction_Homo sapiens_hsa045300.30615633
82Pertussis_Homo sapiens_hsa051330.24706226
83Insulin resistance_Homo sapiens_hsa049310.23541275
84Bladder cancer_Homo sapiens_hsa052190.23382658
85Glucagon signaling pathway_Homo sapiens_hsa049220.22226958
86Notch signaling pathway_Homo sapiens_hsa043300.22074913
87Sulfur relay system_Homo sapiens_hsa041220.20410458
88Adherens junction_Homo sapiens_hsa045200.16128863
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.15145905
90Arachidonic acid metabolism_Homo sapiens_hsa005900.14191891
91Hepatitis C_Homo sapiens_hsa051600.13884029
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.13534047
93Renin secretion_Homo sapiens_hsa049240.13309907
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.08538554
95GnRH signaling pathway_Homo sapiens_hsa049120.07225145
96African trypanosomiasis_Homo sapiens_hsa051430.07090609
97Thyroid cancer_Homo sapiens_hsa052160.06797899
98Influenza A_Homo sapiens_hsa051640.06424613
99Vitamin B6 metabolism_Homo sapiens_hsa007500.05322356
100Circadian rhythm_Homo sapiens_hsa047100.04680268
101N-Glycan biosynthesis_Homo sapiens_hsa005100.04144736
102Intestinal immune network for IgA production_Homo sapiens_hsa046720.03983531
103Asthma_Homo sapiens_hsa053100.03033476
104Ether lipid metabolism_Homo sapiens_hsa005650.03015658
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.01753630
106Vascular smooth muscle contraction_Homo sapiens_hsa042700.01626033
107Type II diabetes mellitus_Homo sapiens_hsa049300.01169027
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.00449088
109Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961-0.0561376
110Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0250384
111Amoebiasis_Homo sapiens_hsa05146-0.0204439
112AMPK signaling pathway_Homo sapiens_hsa04152-0.0158221
113Leukocyte transendothelial migration_Homo sapiens_hsa04670-0.0122717

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