IL21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of isotype switching to IgG isotypes (GO:0048302)8.55466939
2positive regulation of interleukin-2 biosynthetic process (GO:0045086)8.01357397
3regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033397.87436998
4negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)7.75902919
5negative regulation of T-helper cell differentiation (GO:0045623)7.75902919
6positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)7.68342346
7response to interleukin-15 (GO:0070672)7.62401007
8regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)7.54500684
9regulation of interleukin-2 biosynthetic process (GO:0045076)7.53224337
10regulation of chronic inflammatory response (GO:0002676)7.46277931
11* positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)7.33613088
12cellular response to interleukin-15 (GO:0071350)7.10061362
13negative T cell selection (GO:0043383)6.95081808
14regulation of MHC class II biosynthetic process (GO:0045346)6.90556458
15regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)6.71055259
16production of molecular mediator of immune response (GO:0002440)6.66562432
17positive regulation of osteoclast differentiation (GO:0045672)6.30514662
18negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)6.29505640
19negative regulation of adaptive immune response (GO:0002820)6.19704139
20tyrosine phosphorylation of STAT protein (GO:0007260)6.17561738
21positive regulation of isotype switching (GO:0045830)6.17160772
22cytokine production involved in immune response (GO:0002367)6.15280681
23regulation of interleukin-12 biosynthetic process (GO:0045075)5.97721916
24negative thymic T cell selection (GO:0045060)5.81395904
25* regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)5.80786526
26response to mercury ion (GO:0046689)5.78976938
27tolerance induction (GO:0002507)5.66137957
28regulation of proton transport (GO:0010155)5.65312312
29negative regulation of adaptive immune response based on somatic recombination of immune receptors b5.64452027
30negative regulation of alpha-beta T cell differentiation (GO:0046639)5.64096190
31positive regulation of inflammatory response to antigenic stimulus (GO:0002863)5.62421109
32positive regulation of gamma-delta T cell activation (GO:0046645)5.61351367
33regulation of memory T cell differentiation (GO:0043380)5.59560084
34negative regulation of cell killing (GO:0031342)5.37641615
35negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.37641615
36positive regulation of DNA recombination (GO:0045911)5.37191939
37regulation of interleukin-13 production (GO:0032656)5.36603572
38CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)5.24847593
39negative regulation of acute inflammatory response (GO:0002674)5.23540813
40T-helper cell differentiation (GO:0042093)5.21564347
41CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)5.21564347
42viral mRNA export from host cell nucleus (GO:0046784)5.14754860
43positive regulation of activated T cell proliferation (GO:0042104)5.14192924
44regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)5.12473123
45activated T cell proliferation (GO:0050798)5.06548532
46positive regulation of cell fate commitment (GO:0010455)5.00083446
47defense response to protozoan (GO:0042832)4.96483940
48negative regulation of nitric oxide biosynthetic process (GO:0045019)4.92068635
49positive regulation of interleukin-2 production (GO:0032743)4.87218605
50regulation of gamma-delta T cell differentiation (GO:0045586)4.78958716
51T cell selection (GO:0045058)4.76332838
52negative regulation of T cell differentiation in thymus (GO:0033085)4.75053691
53positive regulation of B cell mediated immunity (GO:0002714)4.74726564
54positive regulation of immunoglobulin mediated immune response (GO:0002891)4.74726564
55regulation of vitamin D biosynthetic process (GO:0060556)4.73832203
56regulation of interleukin-6 biosynthetic process (GO:0045408)4.73142768
57response to protozoan (GO:0001562)4.69158599
58regulation of vesicle fusion (GO:0031338)4.63013555
59regulation of isotype switching (GO:0045191)4.58277791
60positive T cell selection (GO:0043368)4.54178870
61necroptotic process (GO:0070266)4.45868388
62positive regulation of myeloid leukocyte differentiation (GO:0002763)4.45832942
63T cell differentiation involved in immune response (GO:0002292)4.39863233
64alpha-beta T cell differentiation involved in immune response (GO:0002293)4.39863233
65alpha-beta T cell activation involved in immune response (GO:0002287)4.39863233
66regulation of gamma-delta T cell activation (GO:0046643)4.34309793
67negative regulation of interleukin-17 production (GO:0032700)4.32552187
68negative regulation of thymocyte apoptotic process (GO:0070244)4.22925722
69regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.19885186
70regulation of nephron tubule epithelial cell differentiation (GO:0072182)4.19383013
71thymic T cell selection (GO:0045061)4.18259631
72positive regulation of chemokine biosynthetic process (GO:0045080)4.17990599
73regulation of vitamin metabolic process (GO:0030656)4.17510357
74positive regulation of astrocyte differentiation (GO:0048711)4.17506487
75negative regulation of T cell mediated immunity (GO:0002710)4.16777333
76negative regulation of B cell mediated immunity (GO:0002713)4.15719779
77negative regulation of immunoglobulin mediated immune response (GO:0002890)4.15719779
78regulation of interleukin-2 production (GO:0032663)4.11839001
79natural killer cell differentiation (GO:0001779)4.06711508
80negative regulation of T cell differentiation (GO:0045581)4.05272990
81positive regulation of T cell differentiation in thymus (GO:0033089)4.04880959
82T cell lineage commitment (GO:0002360)4.03234355
83cytokine biosynthetic process (GO:0042089)3.92275678
84* positive regulation of interleukin-17 production (GO:0032740)3.91057624
85* positive regulation of cell killing (GO:0031343)3.89924085
86* positive regulation of interleukin-10 production (GO:0032733)3.89478335
87positive regulation of macrophage differentiation (GO:0045651)3.86463316
88T cell costimulation (GO:0031295)3.85405265
89regulation of T-helper cell differentiation (GO:0045622)3.84709166
90* positive regulation of lymphocyte mediated immunity (GO:0002708)3.83333888
91positive regulation of immunoglobulin production (GO:0002639)3.82186615
92regulation of immunoglobulin mediated immune response (GO:0002889)3.81424002
93lymphocyte costimulation (GO:0031294)3.79989741
94regulation of DNA recombination (GO:0000018)3.77690886
95alpha-beta T cell differentiation (GO:0046632)3.76151558
96positive regulation of T cell cytokine production (GO:0002726)3.74057305
97regulation of alpha-beta T cell proliferation (GO:0046640)3.74012448
98regulation of activated T cell proliferation (GO:0046006)3.72857377
99positive regulation of cardiac muscle cell differentiation (GO:2000727)3.70483659
100negative regulation of lymphocyte mediated immunity (GO:0002707)3.69011291
101regulation of B cell mediated immunity (GO:0002712)3.68425018
102positive regulation of alpha-beta T cell proliferation (GO:0046641)3.66167765
103leukocyte apoptotic process (GO:0071887)3.65218086
104T cell mediated immunity (GO:0002456)3.64341077
105interferon-gamma production (GO:0032609)3.59875341
106regulation of T cell differentiation in thymus (GO:0033081)3.59011251
107* regulation of interleukin-17 production (GO:0032660)3.58570562
108regulation of epithelial cell differentiation involved in kidney development (GO:2000696)3.57329518
109positive regulation of defense response to virus by host (GO:0002230)3.56785895
110DNA double-strand break processing (GO:0000729)3.53597530
111positive regulation of humoral immune response (GO:0002922)3.52553335
112negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.50982721
113seminiferous tubule development (GO:0072520)3.50700748
114signal transduction in absence of ligand (GO:0038034)3.50579901
115extrinsic apoptotic signaling pathway in absence of ligand (GO:0097192)3.50579901
116alpha-beta T cell activation (GO:0046631)3.48139139
117regulation of cellular senescence (GO:2000772)3.46056608
118CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.45077494
119regulation of interleukin-8 biosynthetic process (GO:0045414)3.44892422
120regulation of T cell mediated cytotoxicity (GO:0001914)3.43731802
121negative regulation of lymphocyte differentiation (GO:0045620)3.42368592
122regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.41870844
123negative regulation of metanephros development (GO:0072217)3.40690680
124regulation of immunoglobulin production (GO:0002637)3.39813294
125lung lobe morphogenesis (GO:0060463)3.38889148
126T cell activation involved in immune response (GO:0002286)3.34656977
127negative regulation of alpha-beta T cell activation (GO:0046636)3.34485963
128* regulation of cell killing (GO:0031341)3.34125699
129* positive regulation of cytokine biosynthetic process (GO:0042108)3.31518094
130* positive regulation of T cell proliferation (GO:0042102)3.29408540
131negative regulation of osteoclast differentiation (GO:0045671)3.29122927
132negative regulation of B cell activation (GO:0050869)3.26271528
133* positive regulation of leukocyte mediated immunity (GO:0002705)3.25685424
134positive regulation of T cell apoptotic process (GO:0070234)3.20923658
135* regulation of lymphocyte mediated immunity (GO:0002706)3.20537626
136regulation of regulatory T cell differentiation (GO:0045589)3.20435193
137myeloid dendritic cell differentiation (GO:0043011)3.20029924
138JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.19842221
139T cell migration (GO:0072678)3.18895663
140regulation of chemokine biosynthetic process (GO:0045073)3.18888040
141cytokine metabolic process (GO:0042107)3.18706255
142regulation of osteoclast differentiation (GO:0045670)3.18461100
143regulation of B cell receptor signaling pathway (GO:0050855)3.16301772
144inflammatory response to antigenic stimulus (GO:0002437)3.16221426
145Peyers patch development (GO:0048541)3.16005926
146mucosal-associated lymphoid tissue development (GO:0048537)3.16005926
147regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.15605234
148N-acetylglucosamine metabolic process (GO:0006044)3.15169684
149* positive regulation of natural killer cell differentiation (GO:0032825)3.15041269
150* positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.14314681
151positive regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045737)3.09020019
152* positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)3.08903812
153regulation of DNA damage checkpoint (GO:2000001)3.06033011
154CD4-positive, alpha-beta T cell activation (GO:0035710)3.04863436
155leukocyte aggregation (GO:0070486)3.01721506
156poly(A)+ mRNA export from nucleus (GO:0016973)2.98998137
157L-fucose catabolic process (GO:0042355)2.95133488
158fucose catabolic process (GO:0019317)2.95133488
159L-fucose metabolic process (GO:0042354)2.95133488
160positive regulation of T cell differentiation (GO:0045582)2.93828260
161* regulation of leukocyte mediated cytotoxicity (GO:0001910)2.91270807
162positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)10.5468527
163regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)10.5468527
164regulation of cytokine production involved in inflammatory response (GO:1900015)10.0481767

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.55540720
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse6.26506396
3* STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.22164293
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.08210872
5* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.84646777
6VDR_22108803_ChIP-Seq_LS180_Human3.41950013
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.23848787
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.18408966
9* RUNX_20019798_ChIP-Seq_JUKART_Human2.96071580
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.60751315
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.45250157
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.36615908
13FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.34918657
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.34486101
15MYB_26560356_Chip-Seq_TH2_Human2.29108653
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.23557988
17PCGF2_27294783_Chip-Seq_ESCs_Mouse2.20229479
18E2F7_22180533_ChIP-Seq_HELA_Human2.19402586
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.18089314
20VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.18034285
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.11968741
22GATA1_22025678_ChIP-Seq_K562_Human2.02621359
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse11.0969632
24BP1_19119308_ChIP-ChIP_Hs578T_Human10.4874438
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.95135287
26RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.89492617
27TP63_19390658_ChIP-ChIP_HaCaT_Human1.87681724
28MAF_26560356_Chip-Seq_TH1_Human1.86110110
29AR_21572438_ChIP-Seq_LNCaP_Human1.85681451
30EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.85418957
31MYB_26560356_Chip-Seq_TH1_Human1.73988306
32IRF8_22096565_ChIP-ChIP_GC-B_Human1.72400677
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.56580305
34MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.55893913
35ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.54225293
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.52606298
37KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.50135781
38PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.49350754
39TAF15_26573619_Chip-Seq_HEK293_Human1.47667127
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38751033
41SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34506213
42MAF_26560356_Chip-Seq_TH2_Human1.33880599
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31052399
44GATA3_27048872_Chip-Seq_THYMUS_Human1.27714153
45IRF8_21731497_ChIP-ChIP_J774_Mouse1.26941318
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26550137
47* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26360289
48STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26078451
49SRY_22984422_ChIP-ChIP_TESTIS_Rat1.23799958
50IRF8_27001747_Chip-Seq_BMDM_Mouse1.22175180
51EWS_26573619_Chip-Seq_HEK293_Human1.20770886
52NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19437381
53RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.18478030
54GBX2_23144817_ChIP-Seq_PC3_Human1.16014826
55PRDM14_20953172_ChIP-Seq_ESCs_Human1.13120212
56EGR1_19032775_ChIP-ChIP_M12_Human1.12335001
57RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12231427
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.11784712
59SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11541662
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09480587
61UTX_26944678_Chip-Seq_JUKART_Human1.09035513
62PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08304293
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07360086
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.06344615
65EGR1_19374776_ChIP-ChIP_THP-1_Human1.04471021
66VDR_21846776_ChIP-Seq_THP-1_Human1.03475160
67BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02631886
68VDR_24763502_ChIP-Seq_THP-1_Human1.02179741
69IGF1R_20145208_ChIP-Seq_DFB_Human1.00959798
70OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99349588
71NOTCH1_21737748_ChIP-Seq_TLL_Human0.99260177
72VDR_24787735_ChIP-Seq_THP-1_Human0.98847375
73CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98458831
74POU3F2_20337985_ChIP-ChIP_501MEL_Human0.95926861
75DROSHA_22980978_ChIP-Seq_HELA_Human0.92078809
76SALL1_21062744_ChIP-ChIP_HESCs_Human0.90584857
77MYC_22102868_ChIP-Seq_BL_Human0.89710480
78CMYC_18555785_Chip-Seq_ESCs_Mouse0.89682658
79CREB1_15753290_ChIP-ChIP_HEK293T_Human0.87697371
80GATA3_26560356_Chip-Seq_TH2_Human0.87224246
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87102857
82ZNF274_21170338_ChIP-Seq_K562_Hela0.87063997
83LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86793997
84ELK1_19687146_ChIP-ChIP_HELA_Human0.86647939
85E2F1_18555785_Chip-Seq_ESCs_Mouse0.84160400
86NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.83946736
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.83637624
88* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.83401662
89PU_27001747_Chip-Seq_BMDM_Mouse0.82813041
90MYC_18555785_ChIP-Seq_MESCs_Mouse0.82239873
91PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.81290092
92* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.80670562
93SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.80000823
94BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78755315
95PU1_27457419_Chip-Seq_LIVER_Mouse0.78413549
96VDR_23849224_ChIP-Seq_CD4+_Human0.76534794
97CRX_20693478_ChIP-Seq_RETINA_Mouse0.76212897
98FOXA1_21572438_ChIP-Seq_LNCaP_Human0.75557976
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.75481306
100KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.75312070
101EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.75076450
102* TP53_22573176_ChIP-Seq_HFKS_Human0.74730739
103P53_22127205_ChIP-Seq_FIBROBLAST_Human0.74655041
104* NMYC_18555785_Chip-Seq_ESCs_Mouse0.74051808
105P300_18555785_Chip-Seq_ESCs_Mouse0.74034562
106EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.73079325
107OCT4_18555785_Chip-Seq_ESCs_Mouse0.72708981
108OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.72623881
109RUNX1_22412390_ChIP-Seq_EML_Mouse0.71917334
110KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.71564592
111SMAD1_18555785_Chip-Seq_ESCs_Mouse0.71501339
112ETS1_20019798_ChIP-Seq_JURKAT_Human0.71321913
113NANOG_18555785_Chip-Seq_ESCs_Mouse0.70739722
114PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.70668008
115ETV1_20927104_ChIP-Seq_GIST48_Human0.69767041
116RBPJ_21746931_ChIP-Seq_IB4_Human0.69698617
117P300_19829295_ChIP-Seq_ESCs_Human0.69505490
118P53_22387025_ChIP-Seq_ESCs_Mouse0.69412960
119ESRRB_18555785_Chip-Seq_ESCs_Mouse0.68661295
120MYB_21317192_ChIP-Seq_ERMYB_Mouse0.67941231
121STAT3_18555785_Chip-Seq_ESCs_Mouse0.67843522
122TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.67593023
123SOX2_19829295_ChIP-Seq_ESCs_Human0.67295607
124NANOG_19829295_ChIP-Seq_ESCs_Human0.67295607
125TP53_16413492_ChIP-PET_HCT116_Human0.67036074
126HOXB7_26014856_ChIP-Seq_BT474_Human0.66638572
127FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.65924920
128RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.65415306
129RUNX1_27457419_Chip-Seq_LIVER_Mouse0.65194369
130* SOX2_18555785_Chip-Seq_ESCs_Mouse0.65022474
131KLF4_18555785_Chip-Seq_ESCs_Mouse0.64252651
132KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.64171190
133KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.64171190
134KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.64171190
135NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.63430279
136TCF7_22412390_ChIP-Seq_EML_Mouse0.62502934
137SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.62070890
138FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.62006384
139FOXP3_21729870_ChIP-Seq_TREG_Human0.61891430
140* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.60633882
141IKZF1_21737484_ChIP-ChIP_HCT116_Human0.60343350
142Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.59995467
143PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.59342271
144TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.59116741
145POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.59116741
146NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.58999965
147CTCF_18555785_Chip-Seq_ESCs_Mouse0.58861379
148SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.58677873
149KDM2B_26808549_Chip-Seq_SUP-B15_Human0.58672181
150SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.58542393
151CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.58300900
152* ZFX_18555785_Chip-Seq_ESCs_Mouse0.58233670
153TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.57220956
154SPI1_23127762_ChIP-Seq_K562_Human0.56522546
155KLF5_20875108_ChIP-Seq_MESCs_Mouse0.55932264
156ZFP57_27257070_Chip-Seq_ESCs_Mouse0.55391751
157* TCF4_22108803_ChIP-Seq_LS180_Human0.55133230
158ERG_20517297_ChIP-Seq_VCAP_Human0.55074427
159GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.54208978
160BCAT_22108803_ChIP-Seq_LS180_Human0.52698698
161PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.52696281

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001348_abnormal_lacrimal_gland7.50525628
2MP0005671_abnormal_response_to5.32611701
3MP0003436_decreased_susceptibility_to4.78672648
4MP0002933_joint_inflammation4.58296091
5MP0003763_abnormal_thymus_physiology4.38477082
6MP0009785_altered_susceptibility_to3.94374670
7MP0001790_abnormal_immune_system3.89369526
8MP0005387_immune_system_phenotype3.89369526
9MP0009333_abnormal_splenocyte_physiolog3.88458395
10MP0001873_stomach_inflammation3.73948430
11MP0000569_abnormal_digit_pigmentation3.46251893
12MP0010155_abnormal_intestine_physiology3.23594395
13MP0001800_abnormal_humoral_immune3.16348930
14MP0003866_abnormal_defecation3.13469359
15* MP0005000_abnormal_immune_tolerance3.11630914
16MP0003646_muscle_fatigue2.94563910
17MP0002148_abnormal_hypersensitivity_rea2.89891932
18MP0002405_respiratory_system_inflammati2.88417176
19MP0002138_abnormal_hepatobiliary_system2.64836692
20MP0000685_abnormal_immune_system2.61430186
21MP0002723_abnormal_immune_serum2.58587621
22MP0001835_abnormal_antigen_presentation2.50959993
23MP0003300_gastrointestinal_ulcer2.43463681
24* MP0002452_abnormal_antigen_presenting2.31999702
25MP0001881_abnormal_mammary_gland2.23712627
26* MP0002420_abnormal_adaptive_immunity2.18247783
27MP0005025_abnormal_response_to2.16392778
28MP0001819_abnormal_immune_cell2.14514859
29MP0004381_abnormal_hair_follicle2.01976285
30MP0000703_abnormal_thymus_morphology1.92633664
31MP0001243_abnormal_dermal_layer1.89867730
32MP0002398_abnormal_bone_marrow1.87678635
33MP0002396_abnormal_hematopoietic_system1.81415507
34MP0000716_abnormal_immune_system1.80810981
35MP0001533_abnormal_skeleton_physiology1.73363385
36MP0001845_abnormal_inflammatory_respons1.71503877
37MP0001502_abnormal_circadian_rhythm1.70857246
38MP0001984_abnormal_olfaction1.70267642
39* MP0000689_abnormal_spleen_morphology1.65373490
40MP0004145_abnormal_muscle_electrophysio1.65313356
41MP0002722_abnormal_immune_system1.64317754
42MP0001853_heart_inflammation1.62449404
43MP0002419_abnormal_innate_immunity1.60721386
44MP0003448_altered_tumor_morphology1.57071554
45MP0006082_CNS_inflammation1.55423157
46MP0001986_abnormal_taste_sensitivity1.54350491
47MP0002102_abnormal_ear_morphology1.54243754
48MP0001968_abnormal_touch/_nociception1.49037873
49MP0002006_tumorigenesis1.42264900
50MP0002429_abnormal_blood_cell1.42223795
51MP0005645_abnormal_hypothalamus_physiol1.41134138
52MP0010368_abnormal_lymphatic_system1.40085450
53MP0005167_abnormal_blood-brain_barrier1.39261803
54MP0002166_altered_tumor_susceptibility1.39086682
55MP0005310_abnormal_salivary_gland1.34163401
56MP0010386_abnormal_urinary_bladder1.33753022
57MP0010307_abnormal_tumor_latency1.33291842
58MP0008569_lethality_at_weaning1.28936768
59MP0003724_increased_susceptibility_to1.28349000
60MP0005166_decreased_susceptibility_to1.27809058
61MP0003136_yellow_coat_color1.27643747
62MP0000627_abnormal_mammary_gland1.26136892
63MP0005408_hypopigmentation1.25084013
64MP0004742_abnormal_vestibular_system1.24464866
65MP0003303_peritoneal_inflammation1.23808117
66MP0001501_abnormal_sleep_pattern1.23041398
67MP0009764_decreased_sensitivity_to1.21487704
68MP0000372_irregular_coat_pigmentation1.20326094
69MP0009840_abnormal_foam_cell1.19284263
70MP0001958_emphysema1.16892584
71MP0005410_abnormal_fertilization1.15208345
72MP0001663_abnormal_digestive_system1.14858238
73MP0002163_abnormal_gland_morphology1.08722270
74MP0001919_abnormal_reproductive_system1.08679176
75MP0002736_abnormal_nociception_after1.07722100
76MP0009745_abnormal_behavioral_response1.04762262
77MP0009765_abnormal_xenobiotic_induced1.03973846
78* MP0008469_abnormal_protein_level1.01516924
79MP0004782_abnormal_surfactant_physiolog1.00504361
80MP0005451_abnormal_body_composition0.99769704
81MP0001727_abnormal_embryo_implantation0.98071511
82MP0004808_abnormal_hematopoietic_stem0.97462414
83MP0002132_abnormal_respiratory_system0.96142190
84MP0003943_abnormal_hepatobiliary_system0.91287147
85MP0002998_abnormal_bone_remodeling0.89886253
86MP0008875_abnormal_xenobiotic_pharmacok0.88892823
87MP0000920_abnormal_myelination0.86932584
88MP0004142_abnormal_muscle_tone0.86629891
89MP0004947_skin_inflammation0.84143552
90MP0008995_early_reproductive_senescence0.82223210
91MP0001485_abnormal_pinna_reflex0.80542127
92MP0005381_digestive/alimentary_phenotyp0.78814871
93MP0005076_abnormal_cell_differentiation0.78782860
94MP0002277_abnormal_respiratory_mucosa0.78534240
95MP0005390_skeleton_phenotype0.78097860
96MP0005501_abnormal_skin_physiology0.76806020
97MP0003045_fibrosis0.74445258
98MP0005165_increased_susceptibility_to0.73697923
99MP0005360_urolithiasis0.69467583
100MP0008873_increased_physiological_sensi0.67863372
101MP0004036_abnormal_muscle_relaxation0.66716218
102MP0002876_abnormal_thyroid_physiology0.65260377
103MP0002693_abnormal_pancreas_physiology0.63719728
104MP0003221_abnormal_cardiomyocyte_apopto0.63349069
105MP0008872_abnormal_physiological_respon0.62744440
106MP0010771_integument_phenotype0.56942975
107MP0010352_gastrointestinal_tract_polyps0.56563784
108MP0005197_abnormal_uvea_morphology0.56014905
109MP0004957_abnormal_blastocyst_morpholog0.55545692
110MP0005464_abnormal_platelet_physiology0.55248556
111MP0003936_abnormal_reproductive_system0.54642043
112MP0005174_abnormal_tail_pigmentation0.54338260
113MP0000377_abnormal_hair_follicle0.53561899
114MP0000490_abnormal_crypts_of0.52928530
115MP0003787_abnormal_imprinting0.52170469
116MP0003938_abnormal_ear_development0.51262976
117MP0001851_eye_inflammation0.51218687
118MP0008775_abnormal_heart_ventricle0.50969244
119MP0001440_abnormal_grooming_behavior0.50911665
120MP0008789_abnormal_olfactory_epithelium0.50820331
121MP0002735_abnormal_chemical_nociception0.50321270
122MP0000604_amyloidosis0.46430276
123MP0000249_abnormal_blood_vessel0.43251585
124MP0003690_abnormal_glial_cell0.41633447
125MP0004510_myositis0.40960921
126MP0008877_abnormal_DNA_methylation0.40118353
127MP0002019_abnormal_tumor_incidence0.38445844
128MP0000858_altered_metastatic_potential0.38315265
129MP0002063_abnormal_learning/memory/cond0.37256876
130MP0003091_abnormal_cell_migration0.36854804
131MP0003959_abnormal_lean_body0.36630100
132MP0008057_abnormal_DNA_replication0.36386522
133MP0003634_abnormal_glial_cell0.35796809
134MP0008770_decreased_survivor_rate0.34319511
135MP0000465_gastrointestinal_hemorrhage0.33865797
136MP0003567_abnormal_fetal_cardiomyocyte0.33351069
137MP0009763_increased_sensitivity_to0.30978479
138MP0005075_abnormal_melanosome_morpholog0.30944808
139MP0004885_abnormal_endolymph0.30771940
140MP0003795_abnormal_bone_structure0.27672788
141MP0000477_abnormal_intestine_morphology0.27158205
142MP0002332_abnormal_exercise_endurance0.26803968
143MP0002184_abnormal_innervation0.26029215
144MP0001191_abnormal_skin_condition0.25810377
145MP0003453_abnormal_keratinocyte_physiol0.25734375

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)7.75848209
2Abnormality of T cell number (HP:0011839)7.43360262
3Megalencephaly (HP:0001355)7.30625347
4Bilateral sensorineural hearing impairment (HP:0008619)7.13516123
5Abnormality of incisor morphology (HP:0011063)7.10512543
6Chronic mucocutaneous candidiasis (HP:0002728)6.80482972
7Recurrent cutaneous fungal infections (HP:0011370)6.80482972
8Recurrent fungal infections (HP:0002841)6.19545703
9* Chronic diarrhea (HP:0002028)6.13423342
10IgA deficiency (HP:0002720)5.99635107
11Thyroiditis (HP:0100646)5.33461278
12Curly hair (HP:0002212)5.27292103
13Stomatitis (HP:0010280)4.94666204
14Abnormality of T cells (HP:0002843)4.85500193
15Pulmonary infiltrates (HP:0002113)4.79542041
16Hemoptysis (HP:0002105)4.72271127
17Cheilitis (HP:0100825)4.68260989
18Optic neuritis (HP:0100653)4.61132152
19Retrobulbar optic neuritis (HP:0100654)4.61132152
20Mutism (HP:0002300)4.60384500
21Recurrent viral infections (HP:0004429)4.59238440
22Fatigue (HP:0012378)4.57896255
23IgM deficiency (HP:0002850)4.10609965
24Myositis (HP:0100614)4.07633971
25Tongue fasciculations (HP:0001308)4.00634742
26Joint swelling (HP:0001386)3.97142262
27Gastrointestinal infarctions (HP:0005244)3.85083227
28Mediastinal lymphadenopathy (HP:0100721)3.70713396
29Abnormality of the distal phalanx of the thumb (HP:0009617)3.63540422
30Eczematoid dermatitis (HP:0000976)3.61848282
31Orchitis (HP:0100796)3.59198876
32Vasculitis (HP:0002633)3.56974760
33Panhypogammaglobulinemia (HP:0003139)3.53233040
34Muscle fibrillation (HP:0010546)3.52875080
35Persistence of primary teeth (HP:0006335)3.42812923
36Cystic hygroma (HP:0000476)3.40186422
37Abnormality of the incisor (HP:0000676)3.39404311
38Elevated erythrocyte sedimentation rate (HP:0003565)3.36811701
39Severe combined immunodeficiency (HP:0004430)3.35467390
40Recurrent skin infections (HP:0001581)3.35308438
41Dysmetric saccades (HP:0000641)3.30852193
42Increased IgM level (HP:0003496)3.29661483
43Scanning speech (HP:0002168)3.27447894
44Abnormality of the prostate (HP:0008775)3.17791614
45Chronic obstructive pulmonary disease (HP:0006510)3.11937012
46Obstructive lung disease (HP:0006536)3.11937012
47Abnormal delayed hypersensitivity skin test (HP:0002963)3.10933277
48Recurrent bronchitis (HP:0002837)3.09669026
49Gangrene (HP:0100758)3.08798153
50IgG deficiency (HP:0004315)3.07137470
51Abnormality of binocular vision (HP:0011514)3.06496433
52Diplopia (HP:0000651)3.06496433
53Arterial thrombosis (HP:0004420)3.02749116
54Thrombocytosis (HP:0001894)3.01889569
55Cerebral hemorrhage (HP:0001342)2.96895706
56Cubitus valgus (HP:0002967)2.95149861
57Exertional dyspnea (HP:0002875)2.91757970
58Autoimmune hemolytic anemia (HP:0001890)2.90926703
59Recurrent sinusitis (HP:0011108)2.89173678
60Myocardial infarction (HP:0001658)2.88035639
61Combined immunodeficiency (HP:0005387)2.87980659
62Meningitis (HP:0001287)2.80829741
63Abnormality of B cell number (HP:0010975)2.79199421
64B lymphocytopenia (HP:0010976)2.79199421
65Pulmonary embolism (HP:0002204)2.77863404
66Pancreatic islet-cell hyperplasia (HP:0004510)2.74843504
67Gastrointestinal stroma tumor (HP:0100723)2.73834028
68Keratoconjunctivitis sicca (HP:0001097)2.71938396
69Deep philtrum (HP:0002002)2.64040154
70Hepatosplenomegaly (HP:0001433)2.63152907
71Concave nail (HP:0001598)2.62736177
72Abnormality of T cell physiology (HP:0011840)2.57678745
73Somatic mutation (HP:0001428)2.54199616
74Chest pain (HP:0100749)2.51087044
75Radioulnar synostosis (HP:0002974)2.50223255
76Abnormality of eosinophils (HP:0001879)2.49291313
77Ureteral stenosis (HP:0000071)2.48988148
78Respiratory difficulties (HP:0002880)2.48649738
79Keratoconjunctivitis (HP:0001096)2.48330352
80Carpal synostosis (HP:0009702)2.44084931
81Conical tooth (HP:0000698)2.42129442
82Adactyly (HP:0009776)2.41578102
83Leukocytosis (HP:0001974)2.40092092
84Disinhibition (HP:0000734)2.37887997
85Amaurosis fugax (HP:0100576)2.36322839
86Arthralgia (HP:0002829)2.36136295
87Acute myeloid leukemia (HP:0004808)2.33784733
88Central scotoma (HP:0000603)2.33391793
89Lymphoma (HP:0002665)2.30868996
90Eosinophilia (HP:0001880)2.29913554
91Abnormality of the endocardium (HP:0004306)2.27567815
92Abnormality of homocysteine metabolism (HP:0010919)2.26500599
93Homocystinuria (HP:0002156)2.26500599
94Neuroblastic tumors (HP:0004376)2.22820317
95Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.22820317
96Neuroblastoma (HP:0003006)2.22820317
97Primitive neuroectodermal tumor (HP:0030065)2.22820317
98Ureteral obstruction (HP:0006000)2.22362507
99Glomerulopathy (HP:0100820)2.19637427
100Lymphopenia (HP:0001888)2.15383869
101Absent hand (HP:0004050)2.14782733
102Tarsal synostosis (HP:0008368)2.14289189
103Increased density of long bones (HP:0006392)2.13152806
104Sensory axonal neuropathy (HP:0003390)2.12877838
105Abnormality of the nasal septum (HP:0000419)2.08468910
106Esophageal varix (HP:0002040)2.08373319
107Encephalitis (HP:0002383)2.08091588
108Pulmonary fibrosis (HP:0002206)2.07780051
109Atonic seizures (HP:0010819)2.07554442
110Genetic anticipation (HP:0003743)2.06907130
111Skull defect (HP:0001362)2.06731677
112Coarse hair (HP:0002208)2.04107155
113Complete atrioventricular canal defect (HP:0001674)2.03489002
114Abnormality of cells of the lymphoid lineage (HP:0012140)2.03370935
115Myelodysplasia (HP:0002863)2.02382628
116Polycythemia (HP:0001901)2.00295207
117Abnormality of the pleura (HP:0002103)1.99606685
118Synostosis involving bones of the hand (HP:0004278)1.98042652
119Abnormality of methionine metabolism (HP:0010901)1.96714776
120Aplasia/Hypoplasia of the macula (HP:0008059)1.96609331
121Increased IgE level (HP:0003212)1.96369229
122Hypergammaglobulinemia (HP:0010702)1.95716089
123Restrictive lung disease (HP:0002091)1.95043320
124Porencephaly (HP:0002132)1.94402626
125Abnormality of abdominal situs (HP:0011620)1.93890833
126Abdominal situs inversus (HP:0003363)1.93890833
127Thrombophlebitis (HP:0004418)1.93027879
128Upper limb muscle weakness (HP:0003484)1.91927025
129Synostosis involving bones of the lower limbs (HP:0009138)1.91808681
130Synostosis involving bones of the feet (HP:0009140)1.91808681
131Granulocytopenia (HP:0001913)1.88587316
132Deviation of the thumb (HP:0009603)1.87498667
133Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.86814623
134Vertigo (HP:0002321)1.86752573
135Abnormality of the gastric mucosa (HP:0004295)1.86227316
136Abnormality of aspartate family amino acid metabolism (HP:0010899)1.86193890
137Aplasia/Hypoplasia affecting the retina (HP:0008061)1.86104989
138Anorexia (HP:0002039)1.84330180
139Hypokalemic alkalosis (HP:0001949)1.83704997
140Portal hypertension (HP:0001409)1.83517873
141Skin rash (HP:0000988)1.83110093
142Short metatarsal (HP:0010743)1.82912843
143Truncal ataxia (HP:0002078)1.82302598
144Abnormality of proline metabolism (HP:0010907)1.79669748
145Hydroxyprolinuria (HP:0003080)1.79669748
146Acrocyanosis (HP:0001063)1.79557855
147Gingival bleeding (HP:0000225)1.79396082
148Abnormality of the hepatic vasculature (HP:0006707)1.77755476
149Aplasia/hypoplasia of the uterus (HP:0008684)1.77171690
150Dyskinesia (HP:0100660)1.76980485
151Abnormality of the fingertips (HP:0001211)1.76776527
152Abnormality of macrophages (HP:0004311)1.75960064
153Sprengel anomaly (HP:0000912)1.74759712
154Inappropriate behavior (HP:0000719)1.74686560
155Pruritus (HP:0000989)1.74626402
156Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.74339399
15711 pairs of ribs (HP:0000878)1.69370004
158Leukopenia (HP:0001882)1.69236383
159Tinnitus (HP:0000360)1.68080410
160Polymicrogyria (HP:0002126)1.67768371
161Abnormality of the anterior horn cell (HP:0006802)1.65897561
162Degeneration of anterior horn cells (HP:0002398)1.65897561
163Peripheral hypomyelination (HP:0007182)1.65245892
164Congenital stationary night blindness (HP:0007642)1.64742193
165Hypoplasia of the thymus (HP:0000778)1.64191746
166Interstitial pulmonary disease (HP:0006530)1.63201310
167Lymphedema (HP:0001004)1.63053646
168Annular pancreas (HP:0001734)1.62889506
169Skin ulcer (HP:0200042)1.62392750
170Tubular atrophy (HP:0000092)1.61927729
171Spontaneous abortion (HP:0005268)1.61677137
172Abnormality of the pericardium (HP:0001697)1.61495907
173Polyneuropathy (HP:0001271)1.60598033

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.96867795
2KSR25.69180070
3EIF2AK35.67127736
4KSR14.72507350
5JAK34.54943440
6EIF2AK14.34075691
7MAP4K14.26849016
8ITK4.02034467
9EPHB13.00068216
10PAK32.95895651
11MAP3K142.87723496
12PRKAA22.63603463
13SCYL22.49845573
14EPHA32.39591768
15NLK2.29402290
16ZAP702.07449807
17LCK2.02565582
18FGFR42.00263668
19TEC1.96379369
20IRAK11.58312396
21BMPR21.58039805
22FGFR31.57937520
23EEF2K1.57656867
24HCK1.53926087
25EIF2AK21.47046793
26PRKCQ1.29103158
27MAP3K121.25786002
28MST41.25608600
29JAK11.22020408
30BTK1.20647767
31CLK11.20281108
32PIM21.20239276
33ACVR1B1.19911401
34IKBKE1.19728627
35NME11.19287776
36SGK11.19131378
37IKBKB1.15089905
38TYK21.14133630
39CDK121.11738335
40PKN11.07651426
41ALK1.06261850
42MAP2K61.05960612
43CSK1.05144268
44CDC71.04905517
45ROCK21.04762806
46WNK41.01948229
47JAK20.98745063
48CSNK1A1L0.98258515
49RPS6KA10.97712868
50MAP2K10.95667641
51SYK0.95199150
52MARK30.93889976
53PRKCH0.92954294
54SIK30.92947930
55STK100.92621629
56ADRBK20.92115001
57CSNK1G10.91572236
58MAP3K70.87581363
59SIK20.81990045
60BCR0.79951396
61PHKG10.78726071
62PHKG20.78726071
63NTRK20.77829567
64LYN0.76386942
65FES0.75709450
66FGFR10.75605023
67MAP3K130.74177071
68BRD40.73359259
69TNIK0.71920002
70BLK0.70028349
71GSK3A0.69487165
72IGF1R0.68308151
73PRKCZ0.68225832
74FYN0.67654860
75TBK10.67243912
76PIK3CA0.66309369
77TRPM70.66117113
78CSNK1A10.66053299
79TRIM280.65810425
80CASK0.62286085
81NME20.61932897
82RIPK10.60316639
83IRAK40.59609409
84SIK10.57884122
85CAMK1G0.57550778
86MAPK110.57142284
87CSNK1D0.56938695
88CHUK0.55855884
89STK160.55699428
90MARK20.54860924
91MKNK20.53118723
92NEK60.51705361
93AKT30.51279445
94GRK60.50954684
95EGFR0.50611109
96OXSR10.49782578
97TTN0.46470397
98PDK10.46381895
99PLK30.45824156
100CAMK1D0.44814971
101RPS6KB10.44381226
102PBK0.44351296
103HIPK20.43064354
104SRPK10.42196184
105MYLK0.42159758
106AKT10.41776177
107IRAK30.41544988
108MAP3K110.41312185
109MAPK100.41290736
110SGK30.40881345
111NEK10.40715081
112STK390.40617883
113PAK60.39966807
114CDK40.39810836
115RPS6KA30.39191199
116FGR0.38985101
117INSR0.38823101
118TLK10.37162810
119PAK10.37154396
120MAPKAPK20.36865491
121PRKCB0.35941598
122TNK20.35902533
123TSSK60.35868310
124BMPR1B0.35379363
125PRPF4B0.34845883
126TAOK10.34791695
127PAK20.33369997
128TYRO30.33112837
129PIM10.32949428
130SGK2230.31228845
131SGK4940.31228845
132CDK60.30745276
133PDGFRB0.30499742
134ABL10.30059712
135CAMKK20.29149699
136LRRK20.28950425
137PRKG10.28042226
138MELK0.26785097
139SGK20.26393561
140KDR0.25858601
141PINK10.25761936
142RAF10.24021138
143CHEK10.23967444
144PTK60.23410908
145MAPK90.22714583
146TAOK20.21820037
147CAMKK10.21502383
148ATM0.21483240
149IRAK20.21120621
150CAMK2D0.20984798
151CAMK2G0.19790020
152CSNK2A20.19222816
153MAPKAPK30.17341879
154PRKACG0.17057577
155TGFBR20.16776060
156GSK3B0.14924612
157CSNK1E0.14806043
158FRK0.14600369
159PRKACB0.12012227

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053325.92567327
2Allograft rejection_Homo sapiens_hsa053305.63528821
3* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053215.53184000
4Type I diabetes mellitus_Homo sapiens_hsa049404.79528159
5Autoimmune thyroid disease_Homo sapiens_hsa053203.29599422
6T cell receptor signaling pathway_Homo sapiens_hsa046603.19822397
7Primary immunodeficiency_Homo sapiens_hsa053402.95449399
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.65425219
9Rheumatoid arthritis_Homo sapiens_hsa053232.59448335
10Measles_Homo sapiens_hsa051622.48735532
11* Jak-STAT signaling pathway_Homo sapiens_hsa046302.35944790
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.22936601
13Asthma_Homo sapiens_hsa053102.15264979
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.01328673
15* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.96372582
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.92009674
17Nitrogen metabolism_Homo sapiens_hsa009101.75637205
18Leishmaniasis_Homo sapiens_hsa051401.71791510
19Hematopoietic cell lineage_Homo sapiens_hsa046401.67153890
20Viral myocarditis_Homo sapiens_hsa054161.66615471
21Proteasome_Homo sapiens_hsa030501.61129587
22Antigen processing and presentation_Homo sapiens_hsa046121.56440062
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.55162729
24African trypanosomiasis_Homo sapiens_hsa051431.52982082
25Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.52844855
26RNA transport_Homo sapiens_hsa030131.50707197
27Malaria_Homo sapiens_hsa051441.45023315
28Osteoclast differentiation_Homo sapiens_hsa043801.31111602
29Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.21708376
30FoxO signaling pathway_Homo sapiens_hsa040681.18787238
31Mineral absorption_Homo sapiens_hsa049781.17115821
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.14181011
33Cysteine and methionine metabolism_Homo sapiens_hsa002700.97864955
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97500257
35Toxoplasmosis_Homo sapiens_hsa051450.97197936
36Chemokine signaling pathway_Homo sapiens_hsa040620.96021217
37B cell receptor signaling pathway_Homo sapiens_hsa046620.92910400
38TNF signaling pathway_Homo sapiens_hsa046680.92066743
39Salmonella infection_Homo sapiens_hsa051320.91968116
40Phototransduction_Homo sapiens_hsa047440.90907349
41HIF-1 signaling pathway_Homo sapiens_hsa040660.85337312
42Systemic lupus erythematosus_Homo sapiens_hsa053220.81911548
43Acute myeloid leukemia_Homo sapiens_hsa052210.81899986
44Prolactin signaling pathway_Homo sapiens_hsa049170.81402032
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81116854
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79654983
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79319136
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77705309
49Renal cell carcinoma_Homo sapiens_hsa052110.77508019
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76820367
51Herpes simplex infection_Homo sapiens_hsa051680.76491858
52Viral carcinogenesis_Homo sapiens_hsa052030.76240402
53mRNA surveillance pathway_Homo sapiens_hsa030150.74415118
54Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74229043
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70479000
56Tuberculosis_Homo sapiens_hsa051520.69427095
57HTLV-I infection_Homo sapiens_hsa051660.68767900
58NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68001372
59Insulin resistance_Homo sapiens_hsa049310.66886262
60Parkinsons disease_Homo sapiens_hsa050120.66260570
61Hepatitis B_Homo sapiens_hsa051610.64079209
62Epstein-Barr virus infection_Homo sapiens_hsa051690.63430577
63Fatty acid biosynthesis_Homo sapiens_hsa000610.61703054
64Influenza A_Homo sapiens_hsa051640.60975168
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57723284
66Vitamin digestion and absorption_Homo sapiens_hsa049770.56103494
67Linoleic acid metabolism_Homo sapiens_hsa005910.55330246
68One carbon pool by folate_Homo sapiens_hsa006700.52776452
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.52274349
70Regulation of autophagy_Homo sapiens_hsa041400.51920560
71MAPK signaling pathway_Homo sapiens_hsa040100.50262829
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49757644
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49717078
74PI3K-Akt signaling pathway_Homo sapiens_hsa041510.49238991
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49026481
76Spliceosome_Homo sapiens_hsa030400.48715468
77Bladder cancer_Homo sapiens_hsa052190.47451844
78Chronic myeloid leukemia_Homo sapiens_hsa052200.46116643
79Taste transduction_Homo sapiens_hsa047420.44689949
80Hepatitis C_Homo sapiens_hsa051600.43707198
81Staphylococcus aureus infection_Homo sapiens_hsa051500.38652284
82Pancreatic cancer_Homo sapiens_hsa052120.37053922
83Thyroid hormone synthesis_Homo sapiens_hsa049180.36291721
84Serotonergic synapse_Homo sapiens_hsa047260.35249115
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35130079
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34868395
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34329338
88Shigellosis_Homo sapiens_hsa051310.33389687
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32885259
90Long-term depression_Homo sapiens_hsa047300.30957352
91Homologous recombination_Homo sapiens_hsa034400.30836140
92VEGF signaling pathway_Homo sapiens_hsa043700.30372042
93Protein digestion and absorption_Homo sapiens_hsa049740.30227028
94Apoptosis_Homo sapiens_hsa042100.29351041
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28702194
96Dorso-ventral axis formation_Homo sapiens_hsa043200.28534326
97Steroid biosynthesis_Homo sapiens_hsa001000.27388827
98Circadian rhythm_Homo sapiens_hsa047100.26891723
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.24227057
100MicroRNAs in cancer_Homo sapiens_hsa052060.23297467
101Non-small cell lung cancer_Homo sapiens_hsa052230.23130312
102Small cell lung cancer_Homo sapiens_hsa052220.22915242
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22179208
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.21825095
105Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.21082380
106Histidine metabolism_Homo sapiens_hsa003400.20088475
107Endocytosis_Homo sapiens_hsa041440.19673384
108Axon guidance_Homo sapiens_hsa043600.19431240
109Legionellosis_Homo sapiens_hsa051340.19149469
110Prostate cancer_Homo sapiens_hsa052150.18680475
111ErbB signaling pathway_Homo sapiens_hsa040120.18075796
112Notch signaling pathway_Homo sapiens_hsa043300.17981851
113Arginine biosynthesis_Homo sapiens_hsa002200.17979200
114Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.17849065
115Long-term potentiation_Homo sapiens_hsa047200.17509871
116Pertussis_Homo sapiens_hsa051330.17253622
117Wnt signaling pathway_Homo sapiens_hsa043100.17250344
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.16729507
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.15273256
120p53 signaling pathway_Homo sapiens_hsa041150.15114452
121Amoebiasis_Homo sapiens_hsa051460.15009812
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.14696267
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.14405336
124Morphine addiction_Homo sapiens_hsa050320.13620701
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.12174439
126Platelet activation_Homo sapiens_hsa046110.11983731
127Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.11457714
128Ether lipid metabolism_Homo sapiens_hsa005650.11244921
129Pathways in cancer_Homo sapiens_hsa052000.10397241
130Choline metabolism in cancer_Homo sapiens_hsa052310.09266316
131Ras signaling pathway_Homo sapiens_hsa040140.08328095
132Nicotine addiction_Homo sapiens_hsa050330.08019882
133Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.07833033
134Colorectal cancer_Homo sapiens_hsa052100.07319285
135mTOR signaling pathway_Homo sapiens_hsa041500.07254150
136Cyanoamino acid metabolism_Homo sapiens_hsa004600.07108333
137Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.06690551
138TGF-beta signaling pathway_Homo sapiens_hsa043500.06639427
139Phosphatidylinositol signaling system_Homo sapiens_hsa040700.06554622
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.06432824
141Rap1 signaling pathway_Homo sapiens_hsa040150.05744443
142Type II diabetes mellitus_Homo sapiens_hsa049300.05396085

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