IL20RA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the type II cytokine receptor family. The encoded protein is a subunit of the receptor for interleukin 20, a cytokine that may be involved in epidermal function. The interleukin 20 receptor is a heterodimeric complex consisting of the encoded protein and interleukin 20 receptor beta. This gene and interleukin 20 receptor beta are highly expressed in skin, and are upregulated in psoriasis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)9.63928403
2axonemal dynein complex assembly (GO:0070286)9.33666489
3cilium or flagellum-dependent cell motility (GO:0001539)7.60690485
4keratinocyte development (GO:0003334)7.46144219
5motile cilium assembly (GO:0044458)7.33217788
6cilium movement (GO:0003341)7.12248447
7establishment of skin barrier (GO:0061436)6.85395370
8viral transcription (GO:0019083)6.61106965
9regulation of water loss via skin (GO:0033561)6.44600117
10atrioventricular valve morphogenesis (GO:0003181)6.31335688
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.26309344
12translational termination (GO:0006415)6.19377624
13ribosomal small subunit biogenesis (GO:0042274)6.07572980
14epithelial cilium movement (GO:0003351)5.85401646
15response to gravity (GO:0009629)5.71779609
16axoneme assembly (GO:0035082)5.32210454
17maturation of SSU-rRNA (GO:0030490)5.29768605
18mitotic cell cycle arrest (GO:0071850)5.28911316
19translational elongation (GO:0006414)5.09691673
20viral life cycle (GO:0019058)4.90261480
21keratinization (GO:0031424)4.88154272
22SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.86696876
23regulation of phospholipase A2 activity (GO:0032429)4.80803603
24keratinocyte proliferation (GO:0043616)4.80362100
25protein targeting to ER (GO:0045047)4.77367925
26pyrimidine-containing compound transmembrane transport (GO:0072531)4.76996266
27cotranslational protein targeting to membrane (GO:0006613)4.73830942
28cellular protein complex disassembly (GO:0043624)4.73652444
29keratinocyte differentiation (GO:0030216)4.69806377
30establishment of protein localization to endoplasmic reticulum (GO:0072599)4.54882333
31nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.53849489
32ribosomal small subunit assembly (GO:0000028)4.45906166
33positive regulation of odontogenesis (GO:0042482)4.43483311
34protein localization to endoplasmic reticulum (GO:0070972)4.39515322
35regulation of Wnt signaling pathway involved in heart development (GO:0003307)4.39486824
36regulation of type B pancreatic cell apoptotic process (GO:2000674)4.32636813
37fusion of sperm to egg plasma membrane (GO:0007342)4.32422375
38positive regulation of receptor recycling (GO:0001921)4.31325232
39primary alcohol catabolic process (GO:0034310)4.29377132
40intraciliary transport (GO:0042073)4.17383461
41left/right pattern formation (GO:0060972)4.14569756
42regulation of ruffle assembly (GO:1900027)4.13001400
43multicellular organismal water homeostasis (GO:0050891)4.02147203
44intestinal epithelial cell development (GO:0060576)4.01556647
45calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.87878245
46sphingomyelin metabolic process (GO:0006684)3.83749489
47protein complex disassembly (GO:0043241)3.82629045
48positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)3.79712349
49cell wall macromolecule catabolic process (GO:0016998)3.79006026
50cell wall macromolecule metabolic process (GO:0044036)3.79006026
51regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.72578059
52ethanol metabolic process (GO:0006067)3.65565383
53cardiac right ventricle morphogenesis (GO:0003215)3.63891898
54translational initiation (GO:0006413)3.63445465
55wound healing, spreading of cells (GO:0044319)3.60660348
56wound healing, spreading of epidermal cells (GO:0035313)3.60423957
57cell-substrate junction assembly (GO:0007044)3.60236221
58heart valve morphogenesis (GO:0003179)3.59382652
59molting cycle (GO:0042303)3.52489124
60hair cycle (GO:0042633)3.52489124
61water homeostasis (GO:0030104)3.51928342
62glandular epithelial cell differentiation (GO:0002067)3.48194785
63response to pheromone (GO:0019236)3.45601537
64lymphoid progenitor cell differentiation (GO:0002320)3.44638759
65epidermis development (GO:0008544)3.43642894
66macromolecular complex disassembly (GO:0032984)3.42970470
67limb bud formation (GO:0060174)3.42053638
68one-carbon compound transport (GO:0019755)3.41328956
69epidermal cell differentiation (GO:0009913)3.40871434
70protein localization to cilium (GO:0061512)3.40080515
71relaxation of cardiac muscle (GO:0055119)3.36114276
72negative regulation of axon extension involved in axon guidance (GO:0048843)3.35397122
73lung epithelium development (GO:0060428)3.35209213
74myeloid dendritic cell differentiation (GO:0043011)3.33881722
75protein targeting to membrane (GO:0006612)3.33382305
76eyelid development in camera-type eye (GO:0061029)3.32781598
77response to corticosterone (GO:0051412)3.31506267
78regulation of cell proliferation involved in kidney development (GO:1901722)3.29004715
79cilium organization (GO:0044782)3.27743083
80positive regulation of osteoblast proliferation (GO:0033690)3.26459743
81regulation of neuron projection regeneration (GO:0070570)3.25944635
82regulation of axon regeneration (GO:0048679)3.25944635
83cilium assembly (GO:0042384)3.24165308
84positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.22463637
85retinol metabolic process (GO:0042572)3.21381317
86regulation of axon extension involved in axon guidance (GO:0048841)3.20299518
87inositol phosphate-mediated signaling (GO:0048016)3.18631216
88cell migration involved in heart development (GO:0060973)3.16156921
89myeloid dendritic cell activation (GO:0001773)3.15105352
90vitamin transmembrane transport (GO:0035461)3.14966871
91apical protein localization (GO:0045176)3.14374402
92long-chain fatty acid biosynthetic process (GO:0042759)3.13855401
93germinal center formation (GO:0002467)3.13744850
94plasma membrane fusion (GO:0045026)3.13238627
95regulation of cilium movement (GO:0003352)3.12057988
96ribosomal large subunit biogenesis (GO:0042273)3.11336990
97cardiac epithelial to mesenchymal transition (GO:0060317)3.08041602
98peptidyl-threonine dephosphorylation (GO:0035970)3.07606419
99negative regulation of glycoprotein biosynthetic process (GO:0010561)3.06591488
100diterpenoid biosynthetic process (GO:0016102)3.04934912
101positive regulation of smoothened signaling pathway (GO:0045880)2.99026131
102sphingoid metabolic process (GO:0046519)2.98621598
103positive regulation of astrocyte differentiation (GO:0048711)2.98060057
104microtubule bundle formation (GO:0001578)2.97312462
105substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.96818232
106substrate-independent telencephalic tangential migration (GO:0021826)2.96818232
107positive regulation of endothelial cell apoptotic process (GO:2000353)2.96204637
108negative regulation of hormone biosynthetic process (GO:0032353)2.94574706
109regulation of hexokinase activity (GO:1903299)2.92233059
110regulation of glucokinase activity (GO:0033131)2.92233059
111L-ascorbic acid metabolic process (GO:0019852)2.91444392
112poly(A)+ mRNA export from nucleus (GO:0016973)2.90806797
113primary alcohol metabolic process (GO:0034308)2.90149545
114left/right axis specification (GO:0070986)2.89946586
115chemosensory behavior (GO:0007635)2.88909400
116negative regulation of keratinocyte proliferation (GO:0010839)2.88433188
117positive regulation of vesicle fusion (GO:0031340)2.85450225
118glutathione derivative biosynthetic process (GO:1901687)2.85285105
119glutathione derivative metabolic process (GO:1901685)2.85285105
120sodium ion homeostasis (GO:0055078)2.84868528
121intermediate filament organization (GO:0045109)2.84252886
122interleukin-1-mediated signaling pathway (GO:0070498)2.83272913
123positive regulation of macroautophagy (GO:0016239)2.82638846
124negative regulation of hormone metabolic process (GO:0032351)2.81385615
125nitric oxide biosynthetic process (GO:0006809)2.80551950
126membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.78617364
127short-term memory (GO:0007614)2.78441092
128relaxation of muscle (GO:0090075)2.78439351
129nitric oxide mediated signal transduction (GO:0007263)2.78133174
130nuclear-transcribed mRNA catabolic process (GO:0000956)2.77787536
131sphingosine metabolic process (GO:0006670)2.77300671
132metanephric nephron tubule development (GO:0072234)2.76838262
133metanephric tubule development (GO:0072170)2.76838262
134bundle of His cell to Purkinje myocyte communication (GO:0086069)2.75600330
135fructose metabolic process (GO:0006000)2.73873002
136interferon-gamma secretion (GO:0072643)2.72505446
137Leydig cell differentiation (GO:0033327)2.72108475
138endosome organization (GO:0007032)2.71924023
139peptide cross-linking (GO:0018149)2.71451224
140glomerular visceral epithelial cell development (GO:0072015)2.70234108
141regulation of receptor recycling (GO:0001919)2.69645269
142regulation of axon guidance (GO:1902667)2.69316103
143ventricular system development (GO:0021591)2.69232158
144mitochondrial calcium ion transport (GO:0006851)2.68202579
145mitotic nuclear envelope reassembly (GO:0007084)2.67806201
146nuclear envelope reassembly (GO:0031468)2.67806201
147multicellular organism reproduction (GO:0032504)2.67489605
148columnar/cuboidal epithelial cell development (GO:0002066)2.66056089
149response to mineralocorticoid (GO:0051385)2.64397126
150placenta blood vessel development (GO:0060674)2.64312998
151lateral sprouting from an epithelium (GO:0060601)2.63841575
152cellular component assembly involved in morphogenesis (GO:0010927)2.63611961
153negative regulation of transcription by competitive promoter binding (GO:0010944)2.62747104
154CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.62629924
155T-helper cell differentiation (GO:0042093)2.62629924
156epithelial cell fate commitment (GO:0072148)2.62224712
157mRNA catabolic process (GO:0006402)2.61652871
158negative regulation of cytosolic calcium ion concentration (GO:0051481)2.60882315
159cerebellar granule cell differentiation (GO:0021707)2.60723036
160regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.59359220
161polyol biosynthetic process (GO:0046173)2.58036942
162negative regulation of T cell differentiation in thymus (GO:0033085)2.57022573
163ethanol oxidation (GO:0006069)2.56426008
164mature B cell differentiation involved in immune response (GO:0002313)2.56133436
165long term synaptic depression (GO:0060292)2.55137912
166parturition (GO:0007567)2.55103633
167membrane repolarization during action potential (GO:0086011)2.55019007
168positive regulation of Cdc42 GTPase activity (GO:0043089)2.54746509
169establishment of protein localization to membrane (GO:0090150)2.54333386
170metanephric nephron epithelium development (GO:0072243)2.54146249
171negative regulation of axon guidance (GO:1902668)2.53859553
172cell projection assembly (GO:0030031)2.53825238
173positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.53189371
174water-soluble vitamin biosynthetic process (GO:0042364)2.51786242
175potassium ion homeostasis (GO:0055075)2.50319333
176iron ion import (GO:0097286)2.47977912
177detection of calcium ion (GO:0005513)2.46871697
178establishment of apical/basal cell polarity (GO:0035089)2.44452905
179tight junction assembly (GO:0070830)2.43422907
180positive regulation of glomerulus development (GO:0090193)2.41790042
181positive regulation of vasodilation (GO:0045909)2.40934074
182retina layer formation (GO:0010842)2.36559528
183endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.36374806
184musculoskeletal movement (GO:0050881)2.35937622
185multicellular organismal movement (GO:0050879)2.35937622
186calcium ion import (GO:0070509)2.35529384
187receptor recycling (GO:0001881)2.35049829
188epithelial cell maturation (GO:0002070)2.34720867
189positive regulation of glycolytic process (GO:0045821)2.34524537
190desmosome organization (GO:0002934)11.9287497

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human6.37897920
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.86151303
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.63144778
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.88556085
5ESR1_21235772_ChIP-Seq_MCF-7_Human3.32191318
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.47111912
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.44249389
8FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.43862217
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.35382216
10P63_26484246_Chip-Seq_KERATINOCYTES_Human2.19968924
11TP63_17297297_ChIP-ChIP_HaCaT_Human15.4159095
12TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.99829693
13PIAS1_25552417_ChIP-Seq_VCAP_Human1.97119030
14SOX9_24532713_ChIP-Seq_HFSC_Mouse1.95707777
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.93348521
16FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.93081165
17FOXM1_26456572_ChIP-Seq_MCF-7_Human1.93068146
18ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.79519900
19SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.74522738
20SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.74522738
21TRIM28_21343339_ChIP-Seq_HEK293_Human1.74142772
22SOX2_27498859_Chip-Seq_STOMACH_Mouse1.71015801
23FOXO3_23340844_ChIP-Seq_DLD1_Human1.65125877
24ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.56877135
25* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.54883109
26GATA4_25053715_ChIP-Seq_YYC3_Human1.53533453
27VDR_22108803_ChIP-Seq_LS180_Human1.50420085
28CJUN_26792858_Chip-Seq_BT549_Human1.46360849
29FOXA1_25552417_ChIP-Seq_VCAP_Human1.45315405
30STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.40464222
31SMAD4_21799915_ChIP-Seq_A2780_Human1.39612097
32TP53_20018659_ChIP-ChIP_R1E_Mouse1.37583070
33* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.34296364
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.31758534
35CDX2_20551321_ChIP-Seq_CACO-2_Human1.31573305
36AR_21572438_ChIP-Seq_LNCaP_Human1.29832455
37TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25276327
38DROSHA_22980978_ChIP-Seq_HELA_Human1.24324639
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22135046
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20250138
41AR_25329375_ChIP-Seq_VCAP_Human1.18565803
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17363421
43FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.16669332
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16185755
45GATA3_24758297_ChIP-Seq_MCF-7_Human1.16107702
46NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.16106312
47* SCL_19346495_ChIP-Seq_HPC-7_Human1.13955771
48SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.13309672
49ZNF263_19887448_ChIP-Seq_K562_Human1.13224861
50RXR_22108803_ChIP-Seq_LS180_Human1.12238319
51NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10480047
52CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08411494
53CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08077272
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.07277619
55FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.06626835
56* KLF5_25053715_ChIP-Seq_YYC3_Human1.06416439
57FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.06101726
58FOXA2_19822575_ChIP-Seq_HepG2_Human1.06085425
59TP63_23658742_ChIP-Seq_EP156T_Human1.05820065
60* CDX2_22108803_ChIP-Seq_LS180_Human1.05593240
61PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05263033
62CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04870989
63* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04573813
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03686849
65* TCF4_22108803_ChIP-Seq_LS180_Human1.03226355
66ESR1_20079471_ChIP-ChIP_T-47D_Human1.03109088
67* GATA6_25053715_ChIP-Seq_YYC3_Human1.01682022
68LXR_22158963_ChIP-Seq_LIVER_Mouse1.01427404
69* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01332160
70* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00074228
71GATA2_21666600_ChIP-Seq_HMVEC_Human0.99749845
72RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99702665
73SMAD3_21741376_ChIP-Seq_EPCs_Human0.99472973
74* BCAT_22108803_ChIP-Seq_LS180_Human0.99414229
75TAF15_26573619_Chip-Seq_HEK293_Human0.99069044
76RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.98756054
77JARID2_20075857_ChIP-Seq_MESCs_Mouse0.98716328
78TP53_18474530_ChIP-ChIP_U2OS_Human0.97972795
79SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.97779106
80EED_16625203_ChIP-ChIP_MESCs_Mouse0.97376792
81RUNX1_27514584_Chip-Seq_MCF-7_Human0.97063692
82ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95914237
83* SOX2_20726797_ChIP-Seq_SW620_Human0.95467114
84SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.94681429
85* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.94465985
86TCF4_18268006_ChIP-ChIP_LS174T_Human0.93705437
87FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.93555850
88EZH2_27294783_Chip-Seq_ESCs_Mouse0.93360539
89DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93010551
90SRY_22984422_ChIP-ChIP_TESTIS_Rat0.92454713
91* SMAD3_21741376_ChIP-Seq_HESCs_Human0.92221964
92SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90655174
93EZH2_27304074_Chip-Seq_ESCs_Mouse0.90437194
94STAT3_23295773_ChIP-Seq_U87_Human0.90045936
95RXR_22158963_ChIP-Seq_LIVER_Mouse0.89913485
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89870855
97* SMAD4_21741376_ChIP-Seq_HESCs_Human0.89793364
98GBX2_23144817_ChIP-Seq_PC3_Human0.89787345
99PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.89560168
100ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89123518
101SMAD_19615063_ChIP-ChIP_OVARY_Human0.89046714
102TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.88857509
103STAT1_20625510_ChIP-Seq_HELA_Human0.88702699
104RNF2_27304074_Chip-Seq_ESCs_Mouse0.88636945
105HTT_18923047_ChIP-ChIP_STHdh_Human0.88404982
106BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88242037
107PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.87883809
108WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87672633
109SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.87097645
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87077111
111SMAD4_21741376_ChIP-Seq_EPCs_Human0.86977467
112NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86899504
113NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.86899504
114EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.86666696
115RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86048936
116JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86032490
117* TP63_22573176_ChIP-Seq_HFKS_Human0.85549071
118* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.85397896
119CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.84999893
120NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.84920355
121CTBP2_25329375_ChIP-Seq_LNCAP_Human0.83474152
122IKZF1_21737484_ChIP-ChIP_HCT116_Human0.83208257
123GATA1_22025678_ChIP-Seq_K562_Human0.82522101
124* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.82088497
125PPAR_26484153_Chip-Seq_NCI-H1993_Human0.82007180
126SA1_27219007_Chip-Seq_ERYTHROID_Human0.81421408
127LXR_22292898_ChIP-Seq_THP-1_Human0.79671963
128* STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.79232354
129CTCF_27219007_Chip-Seq_Bcells_Human0.78484051
130JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78252528
131UBF1/2_26484160_Chip-Seq_HMECs_Human0.76164836
132CBX2_27304074_Chip-Seq_ESCs_Mouse0.73180433
133JARID2_20064375_ChIP-Seq_MESCs_Mouse0.72000696
134BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.71689644
135MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.71607143
136BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.71586710
137RACK7_27058665_Chip-Seq_MCF-7_Human0.70697057
138SA1_27219007_Chip-Seq_Bcells_Human0.69263581
139EZH2_18974828_ChIP-Seq_MESCs_Mouse0.69180182
140RNF2_18974828_ChIP-Seq_MESCs_Mouse0.69180182
141AHR_22903824_ChIP-Seq_MCF-7_Human0.68070649
142ATF3_27146783_Chip-Seq_COLON_Human0.66946210
143STAT4_19710469_ChIP-ChIP_TH1__Mouse0.65300266
144EGR1_19032775_ChIP-ChIP_M12_Human0.64816457
145* CEBPB_22108803_ChIP-Seq_LS180_Human0.63505739
146CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.63363232
147KDM2B_26808549_Chip-Seq_K562_Human0.62705305
148ELF1_20517297_ChIP-Seq_JURKAT_Human0.61787980
149UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.60995435
150GATA3_21867929_ChIP-Seq_TH1_Mouse0.60375975
151ZFP57_27257070_Chip-Seq_ESCs_Mouse0.60026031
152SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.59696478
153GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.59391308
154ERG_21242973_ChIP-ChIP_JURKAT_Human0.59113538
155RUNX_20019798_ChIP-Seq_JUKART_Human0.58800944
156RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.58541503
157NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.58181357
158ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.58050640
159* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.56833965
160TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.56376357
161CBP_21632823_ChIP-Seq_H3396_Human0.55768876
162ELK3_25401928_ChIP-Seq_HUVEC_Human0.54921559
163GATA6_21074721_ChIP-Seq_CACO-2_Human0.54624722
164ARNT_22903824_ChIP-Seq_MCF-7_Human0.54368765
165CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.54360677

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier5.20667325
2MP0004381_abnormal_hair_follicle4.86505663
3MP0000383_abnormal_hair_follicle4.82280650
4MP0009780_abnormal_chondrocyte_physiolo4.76549572
5MP0010234_abnormal_vibrissa_follicle4.15258922
6MP0010678_abnormal_skin_adnexa3.80873522
7MP0005275_abnormal_skin_tensile3.71836511
8MP0002060_abnormal_skin_morphology3.68844407
9MP0002254_reproductive_system_inflammat3.48923949
10MP0000566_synostosis3.39344432
11MP0002877_abnormal_melanocyte_morpholog3.38589650
12MP0003941_abnormal_skin_development3.32250423
13MP0008875_abnormal_xenobiotic_pharmacok3.31732723
14MP0005501_abnormal_skin_physiology3.07726218
15MP0001216_abnormal_epidermal_layer2.97426937
16MP0003453_abnormal_keratinocyte_physiol2.92614879
17MP0009046_muscle_twitch2.85884672
18MP0002909_abnormal_adrenal_gland2.78970164
19MP0009379_abnormal_foot_pigmentation2.72399314
20MP0005409_darkened_coat_color2.71420839
21MP0010771_integument_phenotype2.69213601
22MP0001346_abnormal_lacrimal_gland2.67873075
23MP0000647_abnormal_sebaceous_gland2.63858998
24MP0000579_abnormal_nail_morphology2.42286037
25MP0010386_abnormal_urinary_bladder2.39650243
26MP0004043_abnormal_pH_regulation2.28937923
27MP0000427_abnormal_hair_cycle2.24651936
28MP0000467_abnormal_esophagus_morphology2.21367966
29MP0000377_abnormal_hair_follicle2.20498248
30MP0004185_abnormal_adipocyte_glucose2.09822694
31MP0001851_eye_inflammation1.94524406
32MP0003705_abnormal_hypodermis_morpholog1.84179708
33MP0010352_gastrointestinal_tract_polyps1.79967951
34MP0002098_abnormal_vibrissa_morphology1.79954335
35MP0004947_skin_inflammation1.78861810
36MP0005451_abnormal_body_composition1.78565937
37MP0003122_maternal_imprinting1.78417421
38MP0003566_abnormal_cell_adhesion1.78265475
39MP0001765_abnormal_ion_homeostasis1.75778972
40MP0000013_abnormal_adipose_tissue1.69895132
41MP0009384_cardiac_valve_regurgitation1.66750605
42MP0001191_abnormal_skin_condition1.64241021
43MP0009931_abnormal_skin_appearance1.63622052
44MP0000762_abnormal_tongue_morphology1.61033060
45MP0001756_abnormal_urination1.57402858
46MP0001944_abnormal_pancreas_morphology1.55908786
47MP0001853_heart_inflammation1.48729673
48MP0003136_yellow_coat_color1.48297434
49MP0002272_abnormal_nervous_system1.41443044
50MP0005023_abnormal_wound_healing1.40629496
51MP0003724_increased_susceptibility_to1.39248776
52MP0004742_abnormal_vestibular_system1.39176188
53MP0002163_abnormal_gland_morphology1.36802740
54MP0000462_abnormal_digestive_system1.34539045
55MP0000367_abnormal_coat/_hair1.32497137
56MP0002160_abnormal_reproductive_system1.31461667
57MP0005257_abnormal_intraocular_pressure1.29546587
58MP0003828_pulmonary_edema1.27746162
59MP0002837_dystrophic_cardiac_calcinosis1.27375161
60MP0005083_abnormal_biliary_tract1.26916659
61MP0006035_abnormal_mitochondrial_morpho1.26717304
62MP0004270_analgesia1.22624028
63MP0002653_abnormal_ependyma_morphology1.22223747
64MP0003011_delayed_dark_adaptation1.17959747
65MP0004510_myositis1.17283661
66MP0001243_abnormal_dermal_layer1.16793783
67MP0001664_abnormal_digestion1.16126169
68MP0002693_abnormal_pancreas_physiology1.15321585
69MP0005076_abnormal_cell_differentiation1.14056369
70MP0002234_abnormal_pharynx_morphology1.13022084
71MP0002938_white_spotting1.09821325
72MP0002876_abnormal_thyroid_physiology1.09426662
73MP0004215_abnormal_myocardial_fiber1.09389762
74MP0005636_abnormal_mineral_homeostasis1.08271653
75MP0008872_abnormal_physiological_respon1.07846892
76MP0003283_abnormal_digestive_organ1.05620566
77MP0005174_abnormal_tail_pigmentation1.03183656
78MP0004036_abnormal_muscle_relaxation1.01398335
79MP0000627_abnormal_mammary_gland1.01050128
80MP0001440_abnormal_grooming_behavior1.00964661
81MP0001340_abnormal_eyelid_morphology0.97959946
82MP0004264_abnormal_extraembryonic_tissu0.97065346
83MP0000003_abnormal_adipose_tissue0.95681140
84MP0004782_abnormal_surfactant_physiolog0.95616049
85MP0008961_abnormal_basal_metabolism0.94856425
86MP0005646_abnormal_pituitary_gland0.93292867
87MP0002332_abnormal_exercise_endurance0.90633731
88MP0002132_abnormal_respiratory_system0.90101224
89MP0000470_abnormal_stomach_morphology0.90081135
90MP0002734_abnormal_mechanical_nocicepti0.89955752
91MP0005367_renal/urinary_system_phenotyp0.89664208
92MP0000516_abnormal_urinary_system0.89664208
93MP0005365_abnormal_bile_salt0.89491135
94MP0005645_abnormal_hypothalamus_physiol0.88582560
95MP0000613_abnormal_salivary_gland0.87085549
96MP0002078_abnormal_glucose_homeostasis0.85153756
97MP0004019_abnormal_vitamin_homeostasis0.84580066
98MP0010329_abnormal_lipoprotein_level0.84540643
99MP0006072_abnormal_retinal_apoptosis0.83897832
100MP0003878_abnormal_ear_physiology0.83264912
101MP0005377_hearing/vestibular/ear_phenot0.83264912
102MP0008789_abnormal_olfactory_epithelium0.82508006
103MP0004133_heterotaxia0.82316362
104MP0003195_calcinosis0.79618542
105MP0003953_abnormal_hormone_level0.78517805
106MP0003045_fibrosis0.78432076
107MP0001502_abnormal_circadian_rhythm0.78191702
108MP0005389_reproductive_system_phenotype0.78173223
109MP0002822_catalepsy0.77213467
110MP0003866_abnormal_defecation0.76146401
111MP0002277_abnormal_respiratory_mucosa0.75884591
112MP0002095_abnormal_skin_pigmentation0.75579987
113MP0002148_abnormal_hypersensitivity_rea0.74245276
114MP0004484_altered_response_of0.74140265
115MP0004885_abnormal_endolymph0.73443500
116MP0006036_abnormal_mitochondrial_physio0.73339747
117MP0009643_abnormal_urine_homeostasis0.71899317
118MP0009765_abnormal_xenobiotic_induced0.71217514
119MP0004085_abnormal_heartbeat0.70923261
120MP0005408_hypopigmentation0.70715611
121MP0005165_increased_susceptibility_to0.70010650
122MP0003656_abnormal_erythrocyte_physiolo0.69254011
123MP0003787_abnormal_imprinting0.66816217
124MP0001986_abnormal_taste_sensitivity0.66608353
125MP0001501_abnormal_sleep_pattern0.66384901
126MP0002229_neurodegeneration0.65978831
127MP0003879_abnormal_hair_cell0.65956546
128MP0003763_abnormal_thymus_physiology0.65790194
129MP0002118_abnormal_lipid_homeostasis0.65508145
130MP0001958_emphysema0.64705004
131MP0002638_abnormal_pupillary_reflex0.64590813
132MP0005379_endocrine/exocrine_gland_phen0.64572643
133MP0001485_abnormal_pinna_reflex0.63620358
134MP0000465_gastrointestinal_hemorrhage0.62987956
135MP0002557_abnormal_social/conspecific_i0.61924499
136MP0010155_abnormal_intestine_physiology0.60545879
137MP0002184_abnormal_innervation0.60257857
138MP0002168_other_aberrant_phenotype0.59594788
139MP0008438_abnormal_cutaneous_collagen0.58997124
140MP0005671_abnormal_response_to0.58399175
141MP0002282_abnormal_trachea_morphology0.58213081
142MP0001666_abnormal_nutrient_absorption0.56922092
143MP0001188_hyperpigmentation0.55626840
144MP0002295_abnormal_pulmonary_circulatio0.55602281
145MP0005410_abnormal_fertilization0.55033341
146MP0010030_abnormal_orbit_morphology0.54469445
147MP0003943_abnormal_hepatobiliary_system0.53905793
148MP0005000_abnormal_immune_tolerance0.50502048
149MP0002075_abnormal_coat/hair_pigmentati0.50392422
150MP0008874_decreased_physiological_sensi0.50247637
151MP0005647_abnormal_sex_gland0.50049776
152MP0000858_altered_metastatic_potential0.49427786
153MP0005220_abnormal_exocrine_pancreas0.48911188
154MP0003638_abnormal_response/metabolism_0.48890525
155MP0002998_abnormal_bone_remodeling0.48791215
156MP0009250_abnormal_appendicular_skeleto0.48688248
157MP0005666_abnormal_adipose_tissue0.48540317
158MP0002177_abnormal_outer_ear0.48348980
159MP0001984_abnormal_olfaction0.47466661
160MP0008569_lethality_at_weaning0.47228423
161MP0005464_abnormal_platelet_physiology0.46918000
162MP0003252_abnormal_bile_duct0.45173164
163MP0004272_abnormal_basement_membrane0.44597979
164MP0001542_abnormal_bone_strength0.44145601
165MP0001186_pigmentation_phenotype0.43398471
166MP0005388_respiratory_system_phenotype0.43086823
167MP0002133_abnormal_respiratory_system0.43086823
168MP0003448_altered_tumor_morphology0.41135180
169MP0001784_abnormal_fluid_regulation0.41066724
170MP0002233_abnormal_nose_morphology0.40796329

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.32514318
2Abnormal respiratory epithelium morphology (HP:0012253)7.32855488
3Abnormal respiratory motile cilium morphology (HP:0005938)7.32855488
4Abnormal respiratory motile cilium physiology (HP:0012261)7.24579944
5Abnormal ciliary motility (HP:0012262)7.13614790
6Rhinitis (HP:0012384)6.94756443
7Absent/shortened dynein arms (HP:0200106)6.88041617
8Dynein arm defect of respiratory motile cilia (HP:0012255)6.88041617
9Hypotrichosis (HP:0001006)6.42500850
10Chronic bronchitis (HP:0004469)5.97634990
11Milia (HP:0001056)5.93299941
12Parakeratosis (HP:0001036)5.74537373
13Fragile nails (HP:0001808)5.53257296
14Bronchiectasis (HP:0002110)5.40668081
15Plantar hyperkeratosis (HP:0007556)5.02011893
16Atrophic scars (HP:0001075)4.64319815
17Onycholysis (HP:0001806)4.52467925
18Thick nail (HP:0001805)4.25456013
19Lip pit (HP:0100267)4.23164617
20Nasal polyposis (HP:0100582)4.08954981
21Ridged nail (HP:0001807)3.90467406
22Ankyloglossia (HP:0010296)3.77118007
23Abnormality of the axillary hair (HP:0100134)3.68383963
24Abnormality of secondary sexual hair (HP:0009888)3.68383963
25Fragile skin (HP:0001030)3.64863988
26Pili torti (HP:0003777)3.62292693
27Fatigable weakness (HP:0003473)3.56893261
28Abnormality of the neuromuscular junction (HP:0003398)3.56893261
29Sparse eyelashes (HP:0000653)3.52563677
30Aplasia cutis congenita (HP:0001057)3.48585063
31Aplasia involving bones of the extremities (HP:0009825)3.47535463
32Aplasia involving bones of the upper limbs (HP:0009823)3.47535463
33Aplasia of the phalanges of the hand (HP:0009802)3.47535463
34Woolly hair (HP:0002224)3.46969794
35Abnormal hemoglobin (HP:0011902)3.44058441
36Right ventricular cardiomyopathy (HP:0011663)3.43356475
37Palmoplantar hyperkeratosis (HP:0000972)3.39540298
38Hyperactive renin-angiotensin system (HP:0000841)3.38472717
39Nail dystrophy (HP:0008404)3.36733442
40Erythema (HP:0010783)3.35809314
41Alopecia of scalp (HP:0002293)3.31381140
42White forelock (HP:0002211)3.23467067
43Renal salt wasting (HP:0000127)3.23211915
44Abnormality of cells of the erythroid lineage (HP:0012130)3.19481722
45Corneal erosion (HP:0200020)3.18139338
46Infertility (HP:0000789)3.18069456
47Abnormal blistering of the skin (HP:0008066)3.16357288
48Concave nail (HP:0001598)3.15362930
49Abnormality of cochlea (HP:0000375)3.12243174
50Palmar hyperkeratosis (HP:0010765)3.11109573
51Hyperinsulinemic hypoglycemia (HP:0000825)3.03156582
52Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.01536417
53Hypoglycemic seizures (HP:0002173)2.98707661
54Median cleft lip (HP:0000161)2.95587661
55Hypodontia (HP:0000668)2.90295625
56Distal lower limb muscle weakness (HP:0009053)2.87953868
57Reticulocytopenia (HP:0001896)2.86202807
58Patchy hypopigmentation of hair (HP:0011365)2.84532331
59Bronchitis (HP:0012387)2.82464402
60Recurrent sinusitis (HP:0011108)2.81870156
61Hypophosphatemic rickets (HP:0004912)2.81433348
62Popliteal pterygium (HP:0009756)2.77003260
63Macrocytic anemia (HP:0001972)2.75306929
64Large for gestational age (HP:0001520)2.70293901
65Abnormal sex determination (HP:0012244)2.70103222
66Sex reversal (HP:0012245)2.70103222
67Male infertility (HP:0003251)2.67270531
68Anhidrosis (HP:0000970)2.65777734
69Conical tooth (HP:0000698)2.63680712
70Spinal muscular atrophy (HP:0007269)2.57523426
71Abnormality of oral frenula (HP:0000190)2.56859063
72Hypoglycemic coma (HP:0001325)2.56487482
73Congenital ichthyosiform erythroderma (HP:0007431)2.55949920
74Acanthosis nigricans (HP:0000956)2.55351114
75Dysmetric saccades (HP:0000641)2.54800486
76Ketoacidosis (HP:0001993)2.53980354
77Thin bony cortex (HP:0002753)2.53128882
78Abnormal number of erythroid precursors (HP:0012131)2.51612663
79Abnormality of permanent molar morphology (HP:0011071)2.50057651
80Abnormality of the dental root (HP:0006486)2.50057651
81Taurodontia (HP:0000679)2.50057651
82Conjunctival hamartoma (HP:0100780)2.45458035
83Hyporeflexia of lower limbs (HP:0002600)2.43638557
84Malignant hyperthermia (HP:0002047)2.41998671
85Absent eyebrow (HP:0002223)2.40383337
86Hypohidrosis (HP:0000966)2.40009642
87Mesangial abnormality (HP:0001966)2.38943451
88Amniotic constriction ring (HP:0009775)2.37364899
89Abnormality of placental membranes (HP:0011409)2.37364899
90Abnormality of molar (HP:0011077)2.36867583
91Abnormality of molar morphology (HP:0011070)2.36867583
92Recurrent otitis media (HP:0000403)2.35171809
93Chronic sinusitis (HP:0011109)2.35114696
94Abnormal hair laboratory examination (HP:0003328)2.34908020
95Hyponatremia (HP:0002902)2.31392168
96Ectropion (HP:0000656)2.30818228
97Hyperkalemia (HP:0002153)2.30541548
98Pterygium (HP:0001059)2.30170876
99Blepharitis (HP:0000498)2.28750926
100Flat occiput (HP:0005469)2.27963257
101Pallor (HP:0000980)2.27889552
102Decreased circulating renin level (HP:0003351)2.27518695
103Cystic liver disease (HP:0006706)2.26187123
104Curly hair (HP:0002212)2.23373559
105Abnormality of the dental pulp (HP:0006479)2.23025453
106Premature skin wrinkling (HP:0100678)2.20596709
107Testicular neoplasm (HP:0010788)2.19553013
108Partial duplication of thumb phalanx (HP:0009944)2.19475824
109Weak cry (HP:0001612)2.18637421
110Enlarged epiphyses (HP:0010580)2.17745331
111Pancreatic fibrosis (HP:0100732)2.16786445
112Tubulointerstitial nephritis (HP:0001970)2.16296792
113Occipital encephalocele (HP:0002085)2.16286969
114Abnormality of the nasal mucosa (HP:0000433)2.16067081
115Ventricular tachycardia (HP:0004756)2.14444916
116Morphological abnormality of the middle ear (HP:0008609)2.14210926
117Oligodontia (HP:0000677)2.13977930
118Furrowed tongue (HP:0000221)2.13940432
119Obstructive sleep apnea (HP:0002870)2.13037886
120Abnormality of renin-angiotensin system (HP:0000847)2.13035688
121Morphological abnormality of the inner ear (HP:0011390)2.09951564
122Hypoplasia of dental enamel (HP:0006297)2.09224059
123Abnormality of the 2nd finger (HP:0004100)2.08272481
124Nasolacrimal duct obstruction (HP:0000579)2.08177758
125Congenital, generalized hypertrichosis (HP:0004540)2.06822186
126Postaxial foot polydactyly (HP:0001830)2.06162581
127Hyperglycemia (HP:0003074)2.04462758
128Febrile seizures (HP:0002373)2.03915678
129Esophageal atresia (HP:0002032)2.03856384
130Pruritus (HP:0000989)2.03161355
131Abnormality of sodium homeostasis (HP:0010931)2.02837744
132Symptomatic seizures (HP:0011145)2.01886765
133Hypoplastic nipples (HP:0002557)1.99638472
134Congenital hepatic fibrosis (HP:0002612)1.99253530
135Mesomelia (HP:0003027)1.97695030
136Sparse scalp hair (HP:0002209)1.97365718
137Insulin-resistant diabetes mellitus (HP:0000831)1.97189386
138Upper limb muscle weakness (HP:0003484)1.96542566
139Dysdiadochokinesis (HP:0002075)1.95768076
140Hypothermia (HP:0002045)1.95261365
141Gaze-evoked nystagmus (HP:0000640)1.95240950
142Partial duplication of the phalanx of hand (HP:0009999)1.92931984
143Facial cleft (HP:0002006)1.92644006
144Hypoplastic labia majora (HP:0000059)1.91958339
145Abnormality of the phalanges of the 2nd finger (HP:0009541)1.91245605
146Premature loss of primary teeth (HP:0006323)1.91212581
147Abnormality of the salivary glands (HP:0010286)1.91192099
148Medial flaring of the eyebrow (HP:0010747)1.91175296
149Portal hypertension (HP:0001409)1.89946385
150Thickened helices (HP:0000391)1.89334080
151Abnormality of chloride homeostasis (HP:0011422)1.89152312
152Atelectasis (HP:0100750)1.88848091
153Hypoparathyroidism (HP:0000829)1.87909971
154Periodontitis (HP:0000704)1.86781055
155Distal lower limb amyotrophy (HP:0008944)1.85514604
156True hermaphroditism (HP:0010459)1.85377386
157Abnormality of the hepatic vasculature (HP:0006707)1.83758646
158Hamartoma of the eye (HP:0010568)1.83263907
159Abnormality of the umbilical cord (HP:0010881)1.83093156
160Widely patent fontanelles and sutures (HP:0004492)1.82843586
161Abnormality of the labia majora (HP:0012881)1.81819635
162Delayed epiphyseal ossification (HP:0002663)1.81140333
163Atonic seizures (HP:0010819)1.80998148
164Gout (HP:0001997)1.80099333
165Intention tremor (HP:0002080)1.79680077
166Type I diabetes mellitus (HP:0100651)1.79441855
167Male pseudohermaphroditism (HP:0000037)1.76809287
168Increased IgE level (HP:0003212)1.76481757
169Stenosis of the external auditory canal (HP:0000402)1.74828706
170Short thorax (HP:0010306)1.74035528
171Abnormality of nail color (HP:0100643)1.73430403
172Hyperaldosteronism (HP:0000859)1.72998613
173Pancreatic cysts (HP:0001737)1.72840372
174Nephronophthisis (HP:0000090)1.71212380
175Short nail (HP:0001799)1.70818156
176Ventricular fibrillation (HP:0001663)1.68738379
177Congenital primary aphakia (HP:0007707)1.67962453
178Abnormality of the renal medulla (HP:0100957)1.64459541
179Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.64404214
180Stridor (HP:0010307)1.61787139
181Abnormal drinking behavior (HP:0030082)1.60716161
182Polydipsia (HP:0001959)1.60716161
183Gait imbalance (HP:0002141)1.59671308

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR25.25542163
2FRK4.35472231
3MST1R3.77970041
4TESK23.73784245
5MST43.40837310
6GRK73.20088677
7STK243.01797945
8MOS3.00500465
9MAP3K12.75553239
10MAPK152.74670548
11BMPR22.66822649
12MAP3K122.54989900
13STK102.54363377
14EPHA32.46053962
15MATK2.20262626
16ERN12.19605021
17MAP3K32.18880334
18MAPKAPK32.03034812
19AKT31.70588938
20MAP2K61.67072770
21IKBKB1.66550063
22TESK11.58926151
23FGFR31.56238789
24TGFBR11.55701167
25PRKD31.55662631
26MAP3K21.51095446
27LRRK21.50806745
28MAP2K21.50017380
29GRK51.42529034
30MYLK1.38412158
31PINK11.37869407
32MAP3K91.36961396
33CDK191.34735896
34VRK11.28381119
35MAPKAPK51.27563463
36KIT1.24877105
37LMTK21.23816638
38MAP3K131.23665547
39KSR21.22882926
40NME21.22854180
41MAP4K11.19749901
42PIM21.19660376
43PRKD21.19404976
44EEF2K1.18249453
45STK391.16451896
46EIF2AK11.16361933
47ILK1.15341605
48GRK11.14471012
49NTRK21.13820778
50PASK1.10174908
51BLK1.06072331
52RIPK41.03210443
53TRPM71.03180922
54NLK0.91960494
55EIF2AK20.91274776
56ERBB20.90424876
57ERBB30.88947108
58PRKAA20.87243264
59MET0.84646157
60SGK20.84363793
61JAK20.84316486
62SIK10.83999773
63RPS6KB20.83482149
64BRSK10.82229625
65SMG10.80918560
66CSNK1G10.80907586
67MAP2K10.80626842
68PRKCI0.75871975
69MAP3K110.75272152
70RIPK10.75130847
71FER0.72098675
72ARAF0.70370925
73MARK20.67900912
74BRSK20.67445859
75ADRBK10.66805375
76OXSR10.66469384
77PTK2B0.66444758
78CDK120.66419676
79ADRBK20.65115089
80PTK20.64733860
81CSNK1A10.63504984
82EPHA20.63233630
83CSNK1G20.62740083
84INSRR0.62224719
85SIK30.58225712
86NME10.57510471
87SGK30.55209161
88PNCK0.54157524
89PTK60.54040569
90DYRK1B0.53652770
91TAF10.53562105
92NTRK30.52223210
93PDGFRB0.52167489
94SIK20.51841828
95PRKD10.51745991
96TNIK0.50121374
97RET0.49901841
98FGFR40.49676636
99CDC42BPA0.49060199
100SGK2230.47807963
101SGK4940.47807963
102PAK40.47600118
103PRKCG0.47591805
104STK38L0.47493638
105PIK3CG0.46508934
106NEK60.45892127
107RPS6KA50.44966985
108MAPKAPK20.44891357
109CSNK1G30.44269687
110EPHB10.43697995
111PRKCA0.43447948
112TTK0.43272191
113SYK0.43226689
114RAF10.42453424
115CAMK2G0.42206671
116HIPK20.42017572
117RPS6KA40.41930635
118CAMK2D0.41876746
119YES10.41697852
120PAK20.40126808
121MAPK110.39798723
122MUSK0.39689658
123PRKCE0.39555832
124PHKG10.39411935
125PHKG20.39411935
126TAOK20.39266310
127MAPK40.38814383
128PRKG20.38371213
129FGFR10.37037748
130CSNK1E0.36935745
131IRAK10.35957820
132PRKG10.35406097
133TYK20.35072454
134KSR10.34704934
135ABL20.34554347
136PRKACA0.34494589
137CAMK2A0.34493512
138CSNK1A1L0.33952199
139GSK3A0.33202511
140FES0.33048294
141CAMK10.32146090
142IKBKE0.31842482
143HCK0.31735277
144CASK0.31372847
145WNK10.30939042
146STK380.30229793
147MAPK90.29639569
148ROCK10.29490866
149CHUK0.29047655
150PRKAA10.28370056
151FGFR20.28274519
152AURKA0.28262910
153BRAF0.28161407
154TRIB30.27789034
155LIMK10.27079653
156TAOK10.26681486
157EPHA40.26050222
158ROCK20.24584845
159DMPK0.24299535
160TTN0.24060007
161MAP3K70.23876805
162TBK10.23288726
163PDK10.22574674

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.40926457
2Cyanoamino acid metabolism_Homo sapiens_hsa004604.61105252
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.96683985
4Histidine metabolism_Homo sapiens_hsa003402.72053270
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.71127078
6Nitrogen metabolism_Homo sapiens_hsa009102.50104751
7Bladder cancer_Homo sapiens_hsa052192.47086931
8ECM-receptor interaction_Homo sapiens_hsa045122.46771121
9Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.35624668
10Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.23436098
11Circadian rhythm_Homo sapiens_hsa047102.05124599
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.03991646
13Linoleic acid metabolism_Homo sapiens_hsa005911.97983332
14beta-Alanine metabolism_Homo sapiens_hsa004101.92739868
15Arachidonic acid metabolism_Homo sapiens_hsa005901.89430630
16Insulin secretion_Homo sapiens_hsa049111.73547368
17Dorso-ventral axis formation_Homo sapiens_hsa043201.66895078
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.63562124
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.63310924
20Tyrosine metabolism_Homo sapiens_hsa003501.62424522
21GnRH signaling pathway_Homo sapiens_hsa049121.60674462
22Hedgehog signaling pathway_Homo sapiens_hsa043401.56888864
23Axon guidance_Homo sapiens_hsa043601.52517549
24Amoebiasis_Homo sapiens_hsa051461.46988204
25Basal cell carcinoma_Homo sapiens_hsa052171.46448949
26Protein digestion and absorption_Homo sapiens_hsa049741.45292591
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.42754838
28Renin secretion_Homo sapiens_hsa049241.40685544
29Small cell lung cancer_Homo sapiens_hsa052221.35650329
30Retinol metabolism_Homo sapiens_hsa008301.34263859
31Tight junction_Homo sapiens_hsa045301.34115447
32Fructose and mannose metabolism_Homo sapiens_hsa000511.31438496
33Butanoate metabolism_Homo sapiens_hsa006501.28045743
34Vitamin digestion and absorption_Homo sapiens_hsa049771.27304571
35Pancreatic secretion_Homo sapiens_hsa049721.25259460
36Fatty acid elongation_Homo sapiens_hsa000621.23671568
37GABAergic synapse_Homo sapiens_hsa047271.22856284
38Synaptic vesicle cycle_Homo sapiens_hsa047211.20932556
39VEGF signaling pathway_Homo sapiens_hsa043701.20252208
40Caffeine metabolism_Homo sapiens_hsa002321.19657293
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19434558
42Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.17413074
43Melanogenesis_Homo sapiens_hsa049161.16750285
44Collecting duct acid secretion_Homo sapiens_hsa049661.16655190
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.16430216
46Proteoglycans in cancer_Homo sapiens_hsa052051.14984080
47Platelet activation_Homo sapiens_hsa046111.14615458
48Huntingtons disease_Homo sapiens_hsa050161.14496308
49Osteoclast differentiation_Homo sapiens_hsa043801.13684472
50Ether lipid metabolism_Homo sapiens_hsa005651.12151385
51Circadian entrainment_Homo sapiens_hsa047131.12126724
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11511818
53Thyroid hormone synthesis_Homo sapiens_hsa049181.10765872
54Fatty acid degradation_Homo sapiens_hsa000711.09930131
55ABC transporters_Homo sapiens_hsa020101.08748933
56Aldosterone synthesis and secretion_Homo sapiens_hsa049251.08027636
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05752530
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.04554589
59Chemical carcinogenesis_Homo sapiens_hsa052041.00395135
60Long-term depression_Homo sapiens_hsa047300.97246341
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.96942680
62MicroRNAs in cancer_Homo sapiens_hsa052060.96424682
63Thyroid cancer_Homo sapiens_hsa052160.95309806
64Fatty acid biosynthesis_Homo sapiens_hsa000610.94273816
65Hematopoietic cell lineage_Homo sapiens_hsa046400.94003210
66Sphingolipid metabolism_Homo sapiens_hsa006000.93305537
67* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93299454
68Salivary secretion_Homo sapiens_hsa049700.92756938
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.92449754
70Mineral absorption_Homo sapiens_hsa049780.91525039
71Focal adhesion_Homo sapiens_hsa045100.90341917
72Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88545878
73Notch signaling pathway_Homo sapiens_hsa043300.88357159
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.88334495
75Peroxisome_Homo sapiens_hsa041460.87330600
76Serotonergic synapse_Homo sapiens_hsa047260.86970355
77Cocaine addiction_Homo sapiens_hsa050300.86864060
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86789874
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86365245
80Glycerolipid metabolism_Homo sapiens_hsa005610.86165052
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.85794385
82TNF signaling pathway_Homo sapiens_hsa046680.85354420
83ErbB signaling pathway_Homo sapiens_hsa040120.84212151
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83268601
85Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82632486
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82086370
87Tryptophan metabolism_Homo sapiens_hsa003800.81936935
88Malaria_Homo sapiens_hsa051440.81044643
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80919248
90Toxoplasmosis_Homo sapiens_hsa051450.79975151
91Glutathione metabolism_Homo sapiens_hsa004800.79906356
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79161591
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78236930
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77478490
95Oxidative phosphorylation_Homo sapiens_hsa001900.77390593
96Estrogen signaling pathway_Homo sapiens_hsa049150.77209134
97Type II diabetes mellitus_Homo sapiens_hsa049300.76974900
98Cardiac muscle contraction_Homo sapiens_hsa042600.75651618
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.74681909
100Rap1 signaling pathway_Homo sapiens_hsa040150.74264692
101Ras signaling pathway_Homo sapiens_hsa040140.73184292
102Taste transduction_Homo sapiens_hsa047420.72947148
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72402195
104Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.72179995
105Vibrio cholerae infection_Homo sapiens_hsa051100.71748746
106Protein export_Homo sapiens_hsa030600.71628550
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.71211211
108Non-small cell lung cancer_Homo sapiens_hsa052230.70948972
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69113928
110Wnt signaling pathway_Homo sapiens_hsa043100.67705922
111T cell receptor signaling pathway_Homo sapiens_hsa046600.66815475
112Vitamin B6 metabolism_Homo sapiens_hsa007500.66696206
113Long-term potentiation_Homo sapiens_hsa047200.66527515
114Sulfur metabolism_Homo sapiens_hsa009200.65968557
115Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65908800
116HTLV-I infection_Homo sapiens_hsa051660.64972567
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64425471
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62230937
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61709799
120AMPK signaling pathway_Homo sapiens_hsa041520.60897719
121Dopaminergic synapse_Homo sapiens_hsa047280.60246772
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59052818
123B cell receptor signaling pathway_Homo sapiens_hsa046620.56021196
124Regulation of autophagy_Homo sapiens_hsa041400.55467140
125Inositol phosphate metabolism_Homo sapiens_hsa005620.55442087
126Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55385003
127Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55029344
128Phenylalanine metabolism_Homo sapiens_hsa003600.52916484
129Gastric acid secretion_Homo sapiens_hsa049710.52637543
130MAPK signaling pathway_Homo sapiens_hsa040100.52611323
131mTOR signaling pathway_Homo sapiens_hsa041500.51981162
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.51865472
133Alzheimers disease_Homo sapiens_hsa050100.51809011
134Bile secretion_Homo sapiens_hsa049760.51193161
135Choline metabolism in cancer_Homo sapiens_hsa052310.51129052
136Leishmaniasis_Homo sapiens_hsa051400.50615993
137Oxytocin signaling pathway_Homo sapiens_hsa049210.50449064
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.49822209
139Nicotine addiction_Homo sapiens_hsa050330.48895190
140Ovarian steroidogenesis_Homo sapiens_hsa049130.48525680
141Glucagon signaling pathway_Homo sapiens_hsa049220.48436433
142Renal cell carcinoma_Homo sapiens_hsa052110.48283101
143Calcium signaling pathway_Homo sapiens_hsa040200.47949437
144Fatty acid metabolism_Homo sapiens_hsa012120.46538309
145Dilated cardiomyopathy_Homo sapiens_hsa054140.46262623
146Pentose phosphate pathway_Homo sapiens_hsa000300.45504050
147PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45064242
148Staphylococcus aureus infection_Homo sapiens_hsa051500.45006458
149Leukocyte transendothelial migration_Homo sapiens_hsa046700.44579596
150Acute myeloid leukemia_Homo sapiens_hsa052210.44569858
151Starch and sucrose metabolism_Homo sapiens_hsa005000.44550462
152Glioma_Homo sapiens_hsa052140.43306247
153Pathways in cancer_Homo sapiens_hsa052000.43290994
154Complement and coagulation cascades_Homo sapiens_hsa046100.43217504
155Pertussis_Homo sapiens_hsa051330.43089002
156Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42860436
157Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40157026
158N-Glycan biosynthesis_Homo sapiens_hsa005100.39713444
159Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39649694
160Melanoma_Homo sapiens_hsa052180.38654404
161Amphetamine addiction_Homo sapiens_hsa050310.38406306
162Glutamatergic synapse_Homo sapiens_hsa047240.35983431
163Sphingolipid signaling pathway_Homo sapiens_hsa040710.35408384

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