IL1RN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.01817843
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.01817843
3positive regulation by organism of defense response of other organism involved in symbiotic interact6.01817843
4modulation by symbiont of host immune response (GO:0052553)6.01817843
5positive regulation by symbiont of host defense response (GO:0052509)6.01817843
6modulation by symbiont of host defense response (GO:0052031)6.01817843
7response to peptidoglycan (GO:0032494)5.53753660
8positive regulation of chemokine biosynthetic process (GO:0045080)5.46183383
9neutrophil activation involved in immune response (GO:0002283)5.24361542
10regulation of vitamin metabolic process (GO:0030656)4.95379448
11regulation of cytokine secretion involved in immune response (GO:0002739)4.78378514
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.64422064
13lipopolysaccharide-mediated signaling pathway (GO:0031663)4.63771986
14positive regulation of interferon-alpha production (GO:0032727)4.57674976
15positive regulation of heat generation (GO:0031652)4.57100454
16regulation of chemokine biosynthetic process (GO:0045073)4.51368533
17regulation of fever generation (GO:0031620)4.50751376
18regulation of interferon-alpha production (GO:0032647)4.43223889
19hydrogen peroxide biosynthetic process (GO:0050665)4.40369454
20macrophage activation involved in immune response (GO:0002281)4.38837089
21branching involved in labyrinthine layer morphogenesis (GO:0060670)4.35062690
22regulation of T-helper 1 cell differentiation (GO:0045625)4.30659091
23respiratory burst (GO:0045730)4.22971329
24superoxide anion generation (GO:0042554)4.18738322
25positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.16585817
26granulocyte activation (GO:0036230)4.12557530
27response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.12341463
28response to host immune response (GO:0052572)4.12341463
29positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.08698656
30positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.07192472
31regulation of interferon-beta biosynthetic process (GO:0045357)4.01489470
32myeloid dendritic cell differentiation (GO:0043011)3.89179464
33eosinophil chemotaxis (GO:0048245)3.89138503
34reactive oxygen species biosynthetic process (GO:1903409)3.87590617
35positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.87034811
36immunoglobulin mediated immune response (GO:0016064)3.85216839
37regulation of mononuclear cell migration (GO:0071675)3.80517088
38regulation of activation of Janus kinase activity (GO:0010533)3.78389229
39negative regulation of cytokine production involved in immune response (GO:0002719)3.71809033
40germinal center formation (GO:0002467)3.70973456
41negative regulation of viral genome replication (GO:0045071)3.70793040
42regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.69684169
43negative regulation of nitric oxide biosynthetic process (GO:0045019)3.69439520
44eosinophil migration (GO:0072677)3.68622519
45response to host (GO:0075136)3.68620270
46response to host defenses (GO:0052200)3.68620270
47response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.68620270
48cellular response to type I interferon (GO:0071357)3.67524280
49type I interferon signaling pathway (GO:0060337)3.67524280
50response to protozoan (GO:0001562)3.66728150
51regulation of membrane protein ectodomain proteolysis (GO:0051043)3.66384283
52response to type I interferon (GO:0034340)3.63542252
53neutrophil activation (GO:0042119)3.61590081
54positive regulation of NF-kappaB import into nucleus (GO:0042346)3.59038658
55production of molecular mediator involved in inflammatory response (GO:0002532)3.58408165
56negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.58257379
57positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.57028535
58detection of molecule of bacterial origin (GO:0032490)3.56840217
59positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.56236756
60T-helper 1 type immune response (GO:0042088)3.56152573
61NIK/NF-kappaB signaling (GO:0038061)3.54942601
62positive regulation of mast cell activation involved in immune response (GO:0033008)3.52792682
63positive regulation of mast cell degranulation (GO:0043306)3.52792682
64positive regulation of type 2 immune response (GO:0002830)3.51768552
65interferon-gamma-mediated signaling pathway (GO:0060333)3.51276686
66natural killer cell mediated cytotoxicity (GO:0042267)3.50891088
67natural killer cell mediated immunity (GO:0002228)3.50891088
68microglial cell activation (GO:0001774)3.48814638
69regulation of dendritic cell antigen processing and presentation (GO:0002604)3.47852000
70leukocyte aggregation (GO:0070486)3.44505575
71cellular response to exogenous dsRNA (GO:0071360)3.44109878
72regulation of heat generation (GO:0031650)3.43910980
73regulation of nitric oxide biosynthetic process (GO:0045428)3.43394493
74positive regulation of gamma-delta T cell activation (GO:0046645)3.42704864
75negative regulation of interleukin-17 production (GO:0032700)3.41335613
76positive regulation of interferon-beta production (GO:0032728)3.40226042
77response to muramyl dipeptide (GO:0032495)3.37544683
78myeloid cell activation involved in immune response (GO:0002275)3.36366457
79regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.35514630
80positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.35246160
81regulation of interleukin-12 production (GO:0032655)3.34614608
82defense response to protozoan (GO:0042832)3.33069684
83regulation of immunoglobulin secretion (GO:0051023)3.30857460
84myeloid dendritic cell activation (GO:0001773)3.30771683
85cellular response to lipopolysaccharide (GO:0071222)3.30608838
86regulation of vitamin D biosynthetic process (GO:0060556)3.30061538
87macrophage activation (GO:0042116)3.29078518
88cellular response to interferon-beta (GO:0035458)3.28960555
89regulation of chronic inflammatory response (GO:0002676)3.27981196
90regulation of mast cell degranulation (GO:0043304)3.26938839
91positive regulation of acute inflammatory response (GO:0002675)3.24647312
92positive regulation of interleukin-12 production (GO:0032735)3.23668682
93positive regulation of chemokine production (GO:0032722)3.22332755
94regulation of T-helper cell differentiation (GO:0045622)3.22332300
95negative regulation of interleukin-12 production (GO:0032695)3.22056544
96regulation of interleukin-8 biosynthetic process (GO:0045414)3.21891258
97positive regulation of monocyte chemotaxis (GO:0090026)3.21623611
98cellular response to molecule of bacterial origin (GO:0071219)3.21125396
99positive regulation of lymphocyte migration (GO:2000403)3.20014078
100regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.18865655
101regulation of podosome assembly (GO:0071801)3.17887658
102regulation of NF-kappaB import into nucleus (GO:0042345)3.16646788
103monocyte chemotaxis (GO:0002548)3.16122164
104positive regulation of mast cell activation (GO:0033005)3.15412088
105regulation of lymphocyte chemotaxis (GO:1901623)3.13708131
106lymphocyte chemotaxis (GO:0048247)3.13307146
107modulation of growth of symbiont involved in interaction with host (GO:0044144)3.13260197
108regulation of growth of symbiont in host (GO:0044126)3.13260197
109negative regulation of growth of symbiont in host (GO:0044130)3.13260197
110negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.13260197
111positive regulation of antigen processing and presentation (GO:0002579)3.10099852
112regulation of type I interferon-mediated signaling pathway (GO:0060338)3.10085185
113positive regulation of interleukin-6 production (GO:0032755)3.09738358
114response to interferon-alpha (GO:0035455)3.09623520
115glycosphingolipid catabolic process (GO:0046479)3.09401396
116regulation of interleukin-17 production (GO:0032660)3.08958993
117positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.08879769
118positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.08638210
119negative regulation of myeloid cell apoptotic process (GO:0033033)3.07938505
120dendritic cell differentiation (GO:0097028)3.07479473
121regulation of T-helper 2 cell differentiation (GO:0045628)3.07326424
122regulation of type 2 immune response (GO:0002828)3.07274352
123positive regulation of interleukin-10 production (GO:0032733)3.06699065
124positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)3.06100602
125cellular response to interferon-alpha (GO:0035457)3.05882582
126negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.05490371
127positive regulation of nitric oxide biosynthetic process (GO:0045429)3.04985387
128positive regulation of T-helper cell differentiation (GO:0045624)3.04948940
129cellular extravasation (GO:0045123)3.04688083
130regulation of mast cell activation involved in immune response (GO:0033006)3.04222262
131positive regulation of cytokine biosynthetic process (GO:0042108)3.04220280
132leukocyte mediated cytotoxicity (GO:0001909)3.03797950
133regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.03068369
134positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.02287474
135response to interferon-beta (GO:0035456)3.02021690
136positive regulation of cellular amide metabolic process (GO:0034250)3.01570039
137oligosaccharide catabolic process (GO:0009313)3.00403326
138negative regulation of lipid storage (GO:0010888)2.99879258
139negative regulation of production of molecular mediator of immune response (GO:0002701)2.99617915
140regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.91837257
141regulation of antigen processing and presentation (GO:0002577)2.91646324
142regulation of inflammatory response to antigenic stimulus (GO:0002861)2.89749707
143activation of MAPKKK activity (GO:0000185)2.89406225
144positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.87880557
145cellular response to interferon-gamma (GO:0071346)2.87727586
146regulation of interferon-gamma biosynthetic process (GO:0045072)2.85398618
147adhesion of symbiont to host cell (GO:0044650)2.84373986
148virion attachment to host cell (GO:0019062)2.84373986
149positive regulation of natural killer cell differentiation (GO:0032825)2.82005405

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.63164222
2IRF8_21731497_ChIP-ChIP_J774_Mouse7.28828266
3IRF8_22096565_ChIP-ChIP_GC-B_Human7.09934199
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.53229875
5* IRF8_27001747_Chip-Seq_BMDM_Mouse4.26821619
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.16010568
7* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.88654201
8Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.76555968
9* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.66286143
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.64080852
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.08163128
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.98498596
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.82615693
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.82054297
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.69415248
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.58973178
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.48968925
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.33239306
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.11798546
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.95619478
21BRD4_27068464_Chip-Seq_AML-cells_Mouse1.86778492
22* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.86299380
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.84567512
24PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.78106843
25VDR_24787735_ChIP-Seq_THP-1_Human1.71785330
26SPI1_23547873_ChIP-Seq_NB4_Human1.68677490
27CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.63240788
28CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.62523348
29VDR_21846776_ChIP-Seq_THP-1_Human1.58780827
30PU_27001747_Chip-Seq_BMDM_Mouse1.58408436
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.57975465
32PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.55543182
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.47085917
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37790223
35CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.37298306
36VDR_24763502_ChIP-Seq_THP-1_Human1.36958886
37CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29569947
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.29409335
39* MYB_26560356_Chip-Seq_TH2_Human1.28068029
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.26692945
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26484151
42ESR1_21235772_ChIP-Seq_MCF-7_Human1.25487325
43CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.25323343
44RUNX_20019798_ChIP-Seq_JUKART_Human1.23873700
45* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.22878099
46PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22536031
47TRIM28_21343339_ChIP-Seq_HEK293_Human1.17420438
48NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.16901773
49NRF2_20460467_ChIP-Seq_MEFs_Mouse1.16901773
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14973581
51SPI1_23127762_ChIP-Seq_K562_Human1.13782867
52TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13721910
53GATA2_21666600_ChIP-Seq_HMVEC_Human1.13037879
54KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.11934082
55KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.11934082
56KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.11934082
57FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.11029723
58TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09930054
59* SOX2_20726797_ChIP-Seq_SW620_Human1.06998610
60EGR1_19032775_ChIP-ChIP_M12_Human1.06495864
61GATA1_19941826_ChIP-Seq_K562_Human1.06215855
62PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05618842
63KDM2B_26808549_Chip-Seq_DND41_Human1.05115568
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05000591
65TCF7_22412390_ChIP-Seq_EML_Mouse1.04906797
66GATA1_19941827_ChIP-Seq_MEL_Mouse1.04766834
67MAF_26560356_Chip-Seq_TH1_Human1.04119639
68SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04031387
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03253452
70LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02671529
71ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02171462
72NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01765753
73CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.01195409
74* LXR_22292898_ChIP-Seq_THP-1_Human1.00400029
75VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99000268
76TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98967338
77* GATA3_26560356_Chip-Seq_TH2_Human0.98554501
78STAT1_20625510_ChIP-Seq_HELA_Human0.98407029
79SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.97590207
80CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.96061686
81SCL_19346495_ChIP-Seq_HPC-7_Human0.95879456
82MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.95396360
83KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95123058
84MYB_26560356_Chip-Seq_TH1_Human0.90737063
85IKZF1_21737484_ChIP-ChIP_HCT116_Human0.89913408
86GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89520937
87* GATA3_27048872_Chip-Seq_THYMUS_Human0.89219938
88CJUN_26792858_Chip-Seq_BT549_Human0.88413844
89MAF_26560356_Chip-Seq_TH2_Human0.87778774
90GATA2_22383799_ChIP-Seq_G1ME_Mouse0.87397224
91* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86692282
92RXR_22158963_ChIP-Seq_LIVER_Mouse0.85220901
93JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83535181
94GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83114636
95BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82175593
96* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.81873020
97* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.81873020
98ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.80335179
99LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.80317115
100PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.79621988
101GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78877132
102KDM2B_26808549_Chip-Seq_K562_Human0.78439487
103FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.78336451
104GATA1_22025678_ChIP-Seq_K562_Human0.76633225
105TFEB_21752829_ChIP-Seq_HELA_Human0.74914890
106STAT3_1855785_ChIP-Seq_MESCs_Mouse0.74747030
107* EGR1_23403033_ChIP-Seq_LIVER_Mouse0.73968608
108PU.1_20513432_ChIP-Seq_Bcells_Mouse0.72320065
109E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.69330141
110* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.68567229
111* RARG_19884340_ChIP-ChIP_MEFs_Mouse0.66425729
112FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.65606787
113SPI1_20517297_ChIP-Seq_HL60_Human0.64151862
114UTX_26944678_Chip-Seq_JUKART_Human0.64100768
115GATA2_19941826_ChIP-Seq_K562_Human0.61250993
116ELK3_25401928_ChIP-Seq_HUVEC_Human0.60245214
117CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.58942014
118SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.58889572
119* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.57602238
120FOXO3_23340844_ChIP-Seq_DLD1_Human0.56050728
121SALL4_18804426_ChIP-ChIP_XEN_Mouse0.55491653
122SMRT_27268052_Chip-Seq_Bcells_Human0.53925961
123GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.52298982
124CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.52130182
125ESR2_21235772_ChIP-Seq_MCF-7_Human0.51834592
126LXR_22158963_ChIP-Seq_LIVER_Mouse0.51584293

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009785_altered_susceptibility_to4.61157430
2MP0001835_abnormal_antigen_presentation4.21579286
3MP0003436_decreased_susceptibility_to4.19771423
4MP0003303_peritoneal_inflammation4.15406518
5MP0002148_abnormal_hypersensitivity_rea4.08937070
6MP0006082_CNS_inflammation4.02385172
7* MP0005000_abnormal_immune_tolerance3.38883560
8* MP0002419_abnormal_innate_immunity3.37614921
9* MP0005025_abnormal_response_to3.21321024
10MP0001790_abnormal_immune_system2.66122056
11MP0005387_immune_system_phenotype2.66122056
12MP0002452_abnormal_antigen_presenting2.60481265
13MP0004510_myositis2.54596973
14MP0009764_decreased_sensitivity_to2.53630070
15* MP0003724_increased_susceptibility_to2.52519900
16* MP0002723_abnormal_immune_serum2.48797857
17MP0005671_abnormal_response_to2.46992404
18MP0000685_abnormal_immune_system2.46229017
19MP0002139_abnormal_hepatobiliary_system2.42504912
20MP0001800_abnormal_humoral_immune2.36605418
21* MP0001533_abnormal_skeleton_physiology2.25922100
22MP0001853_heart_inflammation2.17275362
23MP0003075_altered_response_to2.14842122
24MP0000343_altered_response_to2.10722490
25* MP0001819_abnormal_immune_cell2.10190835
26MP0005058_abnormal_lysosome_morphology2.09170063
27MP0005464_abnormal_platelet_physiology2.07281159
28* MP0002420_abnormal_adaptive_immunity2.05786571
29* MP0004947_skin_inflammation2.05446166
30MP0003448_altered_tumor_morphology2.03808463
31* MP0001845_abnormal_inflammatory_respons1.97370296
32MP0009278_abnormal_bone_marrow1.88905151
33MP0002405_respiratory_system_inflammati1.87959930
34MP0002006_tumorigenesis1.82140892
35* MP0008469_abnormal_protein_level1.75081901
36MP0010155_abnormal_intestine_physiology1.71903854
37MP0006054_spinal_hemorrhage1.64816362
38MP0005167_abnormal_blood-brain_barrier1.61864355
39MP0005166_decreased_susceptibility_to1.60234916
40MP0002998_abnormal_bone_remodeling1.57060763
41MP0009333_abnormal_splenocyte_physiolog1.56196990
42MP0000858_altered_metastatic_potential1.49084861
43MP0010352_gastrointestinal_tract_polyps1.40029322
44MP0003806_abnormal_nucleotide_metabolis1.39793776
45MP0000604_amyloidosis1.39327750
46* MP0000716_abnormal_immune_system1.37484955
47MP0003172_abnormal_lysosome_physiology1.36802840
48MP0003828_pulmonary_edema1.34195185
49MP0005310_abnormal_salivary_gland1.32060880
50MP0003186_abnormal_redox_activity1.31558858
51MP0008004_abnormal_stomach_pH1.27527102
52MP0004782_abnormal_surfactant_physiolog1.25238955
53MP0005397_hematopoietic_system_phenotyp1.22740263
54MP0001545_abnormal_hematopoietic_system1.22740263
55MP0003195_calcinosis1.21466483
56* MP0002398_abnormal_bone_marrow1.18629635
57* MP0005164_abnormal_response_to1.17879712
58MP0004858_abnormal_nervous_system1.15049792
59MP0002277_abnormal_respiratory_mucosa1.14799693
60MP0003690_abnormal_glial_cell1.14632971
61* MP0005390_skeleton_phenotype1.14005363
62MP0003191_abnormal_cellular_cholesterol1.11554860
63MP0001542_abnormal_bone_strength1.06155453
64* MP0002429_abnormal_blood_cell1.05629310
65MP0009763_increased_sensitivity_to1.03813080
66MP0005076_abnormal_cell_differentiation1.02367637
67MP0001851_eye_inflammation1.02033332
68MP0002254_reproductive_system_inflammat1.01929872
69MP0009840_abnormal_foam_cell1.01707566
70MP0003300_gastrointestinal_ulcer1.00912988
71MP0000689_abnormal_spleen_morphology0.93275397
72MP0002332_abnormal_exercise_endurance0.92107217
73MP0005257_abnormal_intraocular_pressure0.91430838
74MP0005023_abnormal_wound_healing0.86024457
75* MP0002722_abnormal_immune_system0.84103288
76MP0003656_abnormal_erythrocyte_physiolo0.82018613
77* MP0003453_abnormal_keratinocyte_physiol0.78572599
78MP0008874_decreased_physiological_sensi0.78357039
79MP0005647_abnormal_sex_gland0.77696488
80MP0005666_abnormal_adipose_tissue0.77501921
81MP0008260_abnormal_autophagy0.75885398
82MP0001501_abnormal_sleep_pattern0.75819991
83MP0010307_abnormal_tumor_latency0.74949902
84MP0003795_abnormal_bone_structure0.70994269
85MP0003329_amyloid_beta_deposits0.70489698
86MP0004808_abnormal_hematopoietic_stem0.69732543
87MP0003091_abnormal_cell_migration0.69073526
88MP0008438_abnormal_cutaneous_collagen0.68396470
89MP0003566_abnormal_cell_adhesion0.67834681
90MP0003763_abnormal_thymus_physiology0.66804420
91* MP0000249_abnormal_blood_vessel0.65278894
92MP0005266_abnormal_metabolism0.64956067
93MP0002136_abnormal_kidney_physiology0.63247641
94MP0000569_abnormal_digit_pigmentation0.62688628
95MP0010386_abnormal_urinary_bladder0.62236553
96MP0002877_abnormal_melanocyte_morpholog0.61190946
97MP0003045_fibrosis0.60882758
98MP0005165_increased_susceptibility_to0.59325185
99MP0000371_diluted_coat_color0.57501120
100MP0002166_altered_tumor_susceptibility0.56959799
101MP0005451_abnormal_body_composition0.56676139
102MP0003183_abnormal_peptide_metabolism0.54907412
103MP0003705_abnormal_hypodermis_morpholog0.54729884
104MP0001958_emphysema0.54728821
105MP0000920_abnormal_myelination0.54589931
106MP0002138_abnormal_hepatobiliary_system0.54034295
107MP0009765_abnormal_xenobiotic_induced0.53664618
108MP0005319_abnormal_enzyme/_coenzyme0.52436915
109* MP0005535_abnormal_body_temperature0.52279082
110MP0001663_abnormal_digestive_system0.51668729
111MP0003646_muscle_fatigue0.51218418
112MP0000609_abnormal_liver_physiology0.50672927
113MP0002295_abnormal_pulmonary_circulatio0.50065911
114MP0005381_digestive/alimentary_phenotyp0.50007515
115MP0000465_gastrointestinal_hemorrhage0.49946737
116* MP0002933_joint_inflammation0.49866113
117MP0005595_abnormal_vascular_smooth0.49463652
118MP0002693_abnormal_pancreas_physiology0.47652880
119MP0001764_abnormal_homeostasis0.47252832

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)7.85287568
2Recurrent abscess formation (HP:0002722)7.70227591
3Recurrent bacterial skin infections (HP:0005406)7.04382315
4Recurrent gram-negative bacterial infections (HP:0005420)6.92211981
5Mediastinal lymphadenopathy (HP:0100721)5.73196706
6Abnormality of macrophages (HP:0004311)5.62110045
7Elevated erythrocyte sedimentation rate (HP:0003565)5.33567254
8Orchitis (HP:0100796)4.81074435
9Optic neuritis (HP:0100653)4.70128864
10Retrobulbar optic neuritis (HP:0100654)4.70128864
11Autoimmune thrombocytopenia (HP:0001973)4.61200681
12Gingivitis (HP:0000230)4.53037398
13Myositis (HP:0100614)4.46592175
14Loss of speech (HP:0002371)4.39086583
15Systemic lupus erythematosus (HP:0002725)4.26812405
16Recurrent skin infections (HP:0001581)4.23757638
17Obstructive lung disease (HP:0006536)4.21987244
18Chronic obstructive pulmonary disease (HP:0006510)4.21987244
19Increased cerebral lipofuscin (HP:0011813)3.86026464
20Increased neuronal autofluorescent lipopigment (HP:0002074)3.80776142
21Vasculitis (HP:0002633)3.75065387
22Recurrent fungal infections (HP:0002841)3.73571266
23Increased IgM level (HP:0003496)3.70975707
24Mutism (HP:0002300)3.70306896
25Nuclear cataract (HP:0100018)3.69417569
26Basal ganglia calcification (HP:0002135)3.57794634
27Vacuolated lymphocytes (HP:0001922)3.47006291
28Prostate neoplasm (HP:0100787)3.45812328
29Thick nail (HP:0001805)3.30683687
30Tetraparesis (HP:0002273)3.25464021
31Axonal loss (HP:0003447)3.24895523
32Urticaria (HP:0001025)3.21270806
33Abnormality of polysaccharide metabolism (HP:0011012)3.15159896
34Abnormality of glycosaminoglycan metabolism (HP:0004371)3.15159896
35Abnormality of mucopolysaccharide metabolism (HP:0011020)3.15159896
36Neurofibrillary tangles (HP:0002185)3.12894298
37Periodontitis (HP:0000704)3.08702704
38Pustule (HP:0200039)3.02629717
39Pulmonary infiltrates (HP:0002113)3.01645252
40Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.00789414
41Cellulitis (HP:0100658)2.99017141
42Disinhibition (HP:0000734)2.98407469
43Recurrent viral infections (HP:0004429)2.97399786
44Mucopolysacchariduria (HP:0008155)2.96079914
45Urinary glycosaminoglycan excretion (HP:0003541)2.96079914
46Poor head control (HP:0002421)2.87119861
47Recurrent cutaneous fungal infections (HP:0011370)2.78058918
48Chronic mucocutaneous candidiasis (HP:0002728)2.78058918
49* Stomatitis (HP:0010280)2.76969932
50Apathy (HP:0000741)2.76756940
51Gastrointestinal infarctions (HP:0005244)2.71235223
52Recurrent pneumonia (HP:0006532)2.69173394
53Keratoconjunctivitis sicca (HP:0001097)2.68143358
54Hypergammaglobulinemia (HP:0010702)2.67129847
55Diminished motivation (HP:0000745)2.65991886
56Peritonitis (HP:0002586)2.61680584
57Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.61237718
58Myocardial infarction (HP:0001658)2.59564084
59Metaphyseal irregularity (HP:0003025)2.56082141
60Keratoconjunctivitis (HP:0001096)2.55740723
61Meningitis (HP:0001287)2.55546342
62Arterial thrombosis (HP:0004420)2.55297761
63Abnormality of the pericardium (HP:0001697)2.54983414
64Polyneuropathy (HP:0001271)2.54301636
65Inappropriate behavior (HP:0000719)2.51405465
66Nausea (HP:0002018)2.49851906
67Petechiae (HP:0000967)2.49748957
68Leukocytosis (HP:0001974)2.48802224
69Hemoptysis (HP:0002105)2.48796259
70Abnormality of glycolipid metabolism (HP:0010969)2.45817882
71Abnormality of liposaccharide metabolism (HP:0010968)2.45817882
72Abnormality of glycosphingolipid metabolism (HP:0004343)2.45817882
73Increased IgE level (HP:0003212)2.43995489
74Porencephaly (HP:0002132)2.43796479
75Progressive neurologic deterioration (HP:0002344)2.43055259
76Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.41588337
77Premature loss of primary teeth (HP:0006323)2.41410974
78Recurrent lower respiratory tract infections (HP:0002783)2.39518277
79Vertebral compression fractures (HP:0002953)2.38659829
80Osteomyelitis (HP:0002754)2.36472172
81T lymphocytopenia (HP:0005403)2.33771654
82Encephalitis (HP:0002383)2.30393153
83Purpura (HP:0000979)2.30019044
84Anorexia (HP:0002039)2.28063248
85Thin bony cortex (HP:0002753)2.27289944
86Complement deficiency (HP:0004431)2.24746578
87Gingival bleeding (HP:0000225)2.24380212
88Cerebral inclusion bodies (HP:0100314)2.23337962
89Parakeratosis (HP:0001036)2.23104882
90Neuronal loss in central nervous system (HP:0002529)2.21511236
91Neoplasm of head and neck (HP:0012288)2.21461056
92Esophageal neoplasm (HP:0100751)2.21461056
93Hepatosplenomegaly (HP:0001433)2.20353394
94Osteolytic defects of the phalanges of the hand (HP:0009771)2.19806467
95Osteolytic defects of the hand bones (HP:0009699)2.19806467
96Vertigo (HP:0002321)2.17836281
97Bone pain (HP:0002653)2.14535340
98Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.14279768
99Dysostosis multiplex (HP:0000943)2.13913987
100Acne (HP:0001061)2.13766738
101Memory impairment (HP:0002354)2.11231247
102Chronic otitis media (HP:0000389)2.11096618
103Gangrene (HP:0100758)2.10775110
104Glomerulonephritis (HP:0000099)2.10773082
105Nephritis (HP:0000123)2.10161181
106Abnormality of the pleura (HP:0002103)2.09535357
107Joint hemorrhage (HP:0005261)2.04252381
108Generalized aminoaciduria (HP:0002909)2.02084982
109Progressive visual loss (HP:0000529)2.01785131
110Pulmonary embolism (HP:0002204)2.01109069
111Keratitis (HP:0000491)1.98967250
112Increased serum ferritin (HP:0003281)1.98020863
113Hematochezia (HP:0002573)1.97889542
114Autoimmune hemolytic anemia (HP:0001890)1.97521487
115Personality changes (HP:0000751)1.96154213
116Hemorrhage of the eye (HP:0011885)1.93127478
117Glomerulopathy (HP:0100820)1.92928709
118Malnutrition (HP:0004395)1.92797239
119Agnosia (HP:0010524)1.92515977
120Prolonged neonatal jaundice (HP:0006579)1.92182455
121Skin ulcer (HP:0200042)1.90158074
122Episodic fever (HP:0001954)1.89568728
123Sepsis (HP:0100806)1.89529395
124Upper motor neuron abnormality (HP:0002127)1.89431284
125Dementia (HP:0000726)1.88077113
126Abnormality of the prostate (HP:0008775)1.87148602
127Pathologic fracture (HP:0002756)1.83584905
128* Arthralgia (HP:0002829)1.81871746
129Cheilitis (HP:0100825)1.81457676
130Lower limb hyperreflexia (HP:0002395)1.78147178
131Eosinophilia (HP:0001880)1.75761660
132Amyloidosis (HP:0011034)1.75683818
133Abnormality of T cell number (HP:0011839)1.75070429
134Abnormality of iron homeostasis (HP:0011031)1.73770966
135Abnormality of the vasculature of the conjunctiva (HP:0008054)1.70540482
136Abnormality of the endocardium (HP:0004306)1.70195301

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK4.68880467
2MAP3K144.50184557
3BLK4.37696881
4RIPK44.16820658
5TBK14.02732253
6IRAK33.31016877
7IRAK42.95949113
8TYK22.75668491
9IKBKE2.72294373
10IKBKB2.52295767
11TXK2.51990742
12ERN12.30927414
13JAK32.27854863
14TAOK12.21081435
15PRPF4B2.07711680
16MAP4K11.98868300
17PIM21.94222223
18JAK11.77721233
19CSK1.62815834
20CHUK1.60093470
21MST41.59728644
22KIT1.59612779
23MST1R1.56935507
24FGR1.55309583
25CDC42BPA1.47979991
26BMX1.44322537
27EPHB11.40961890
28ABL21.40720984
29MAP3K131.38975809
30BMPR21.37297523
31HCK1.22209009
32SYK1.20639260
33NEK91.18993232
34ZAP701.18643504
35LYN1.15109312
36NME21.08627411
37RPS6KA41.06619085
38MATK1.06558086
39MARK31.06526834
40LATS21.01934720
41EIF2AK21.00404515
42SIK30.98470972
43EPHA30.96869640
44JAK20.96204458
45ACVR1B0.95148193
46STK100.93823947
47ERBB40.91461209
48RIPK10.91243233
49PIM10.89787023
50ERBB30.89090201
51LCK0.88474603
52TYRO30.87897596
53MAP3K50.84981688
54GRK70.83548769
55IRAK10.79700812
56PRKCD0.78780475
57FGFR30.78725284
58BTK0.77033468
59ARAF0.75651715
60FGFR40.73269341
61DYRK30.71225192
62TRPM70.70167226
63CSF1R0.69504253
64MAP2K60.68543986
65ABL10.68304486
66YES10.66728483
67STK40.64382548
68EGFR0.64324548
69LRRK20.62361862
70CLK10.60237261
71FES0.59285228
72MAP3K10.59276509
73CDK60.58875121
74ADRBK20.58807082
75IRAK20.57407411
76TEC0.55556059
77PKN10.54433013
78HIPK20.54273021
79BMPR1B0.53751963
80MOS0.52012409
81MAPK40.51448724
82MAP3K110.51386813
83MAP3K120.51165178
84TAOK30.49119414
85STK240.47819394
86DAPK20.46746675
87TESK10.46259084
88KSR20.45713655
89PDGFRA0.45581351
90STK30.41438961
91PRKCQ0.40454919
92TRIB30.39029397
93PRKG20.38476778
94TESK20.38245123
95DDR20.37987776
96TGFBR20.37084661
97FYN0.36591112
98DYRK1B0.36223814
99MAP3K30.35183602
100MAPKAPK20.35121516
101MAP3K100.34056692
102SIK20.33307045
103RPS6KL10.33270447
104RPS6KC10.33270447
105ICK0.33124800
106MAPK70.31778900
107PDK10.30657786
108DAPK30.30114722
109PLK20.29916106
110TTN0.25700844
111ADRBK10.25666783
112RPS6KA60.25158722
113PAK40.24876173
114ALK0.24198007
115PTK60.24044060
116PDGFRB0.23837680
117CAMKK20.23442048
118MUSK0.23230801
119TAOK20.22686532
120RPS6KA10.22540402
121GSK3A0.22430296
122PDPK10.22241927
123CAMK1D0.21525593
124INSR0.21144562
125IGF1R0.20052978
126MET0.19171820
127MAP2K30.18113353
128ITK0.17772460
129PIK3CG0.17501767
130CDK140.15069674

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053324.09737760
2Leishmaniasis_Homo sapiens_hsa051403.56963470
3Toll-like receptor signaling pathway_Homo sapiens_hsa046203.05625633
4Staphylococcus aureus infection_Homo sapiens_hsa051503.04177111
5Legionellosis_Homo sapiens_hsa051342.92241874
6Allograft rejection_Homo sapiens_hsa053302.91950973
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.86466636
8Type I diabetes mellitus_Homo sapiens_hsa049402.71864633
9Rheumatoid arthritis_Homo sapiens_hsa053232.69116569
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.68494632
11NOD-like receptor signaling pathway_Homo sapiens_hsa046212.68045972
12Malaria_Homo sapiens_hsa051442.59496554
13Asthma_Homo sapiens_hsa053102.53600280
14Pertussis_Homo sapiens_hsa051332.53348708
15Tuberculosis_Homo sapiens_hsa051522.35070626
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.30592452
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.26364595
18Osteoclast differentiation_Homo sapiens_hsa043802.14250480
19TNF signaling pathway_Homo sapiens_hsa046682.11842660
20Salmonella infection_Homo sapiens_hsa051322.04268793
21African trypanosomiasis_Homo sapiens_hsa051431.98521978
22Measles_Homo sapiens_hsa051621.93894869
23Influenza A_Homo sapiens_hsa051641.82747616
24Phagosome_Homo sapiens_hsa041451.68946354
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.66429722
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.61957751
27Hematopoietic cell lineage_Homo sapiens_hsa046401.58901893
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.53806611
29Herpes simplex infection_Homo sapiens_hsa051681.45408218
30Lysosome_Homo sapiens_hsa041421.45289151
31Toxoplasmosis_Homo sapiens_hsa051451.39256757
32Autoimmune thyroid disease_Homo sapiens_hsa053201.31357771
33Chemokine signaling pathway_Homo sapiens_hsa040621.27123141
34Amoebiasis_Homo sapiens_hsa051461.19079546
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.17415270
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.10306763
37Apoptosis_Homo sapiens_hsa042101.10026456
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05632927
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.04804913
40Shigellosis_Homo sapiens_hsa051311.04547623
41B cell receptor signaling pathway_Homo sapiens_hsa046621.04359599
42Hepatitis C_Homo sapiens_hsa051600.98998602
43Prion diseases_Homo sapiens_hsa050200.98156824
44Hepatitis B_Homo sapiens_hsa051610.96954159
45Antigen processing and presentation_Homo sapiens_hsa046120.90346503
46Bladder cancer_Homo sapiens_hsa052190.90170847
47Viral myocarditis_Homo sapiens_hsa054160.86270840
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83993351
49Collecting duct acid secretion_Homo sapiens_hsa049660.83066864
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77777898
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75527464
52Complement and coagulation cascades_Homo sapiens_hsa046100.75312738
53Mineral absorption_Homo sapiens_hsa049780.70564813
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69817858
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67645075
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.65846849
57Other glycan degradation_Homo sapiens_hsa005110.62929135
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.61070986
59Sulfur metabolism_Homo sapiens_hsa009200.57763891
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56934580
61Glycosaminoglycan degradation_Homo sapiens_hsa005310.56523441
62T cell receptor signaling pathway_Homo sapiens_hsa046600.55041606
63Primary immunodeficiency_Homo sapiens_hsa053400.52220625
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50314201
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47566115
66HIF-1 signaling pathway_Homo sapiens_hsa040660.44411979
67Acute myeloid leukemia_Homo sapiens_hsa052210.44305232
68Prolactin signaling pathway_Homo sapiens_hsa049170.41938235
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40540365
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.39626890
71Epstein-Barr virus infection_Homo sapiens_hsa051690.38851088
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38189354
73PPAR signaling pathway_Homo sapiens_hsa033200.35723726
74Type II diabetes mellitus_Homo sapiens_hsa049300.35132573
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.34628843
76Chronic myeloid leukemia_Homo sapiens_hsa052200.34515412
77Platelet activation_Homo sapiens_hsa046110.34039770
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32009067
79Galactose metabolism_Homo sapiens_hsa000520.31400789
80Small cell lung cancer_Homo sapiens_hsa052220.31129368
81Dorso-ventral axis formation_Homo sapiens_hsa043200.30987484
82Tryptophan metabolism_Homo sapiens_hsa003800.30363613
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.29888921
84Pancreatic cancer_Homo sapiens_hsa052120.29870649
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.29442305
86Proteoglycans in cancer_Homo sapiens_hsa052050.26327274
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26152320
88Systemic lupus erythematosus_Homo sapiens_hsa053220.25342077
89Fructose and mannose metabolism_Homo sapiens_hsa000510.25311484
90Vibrio cholerae infection_Homo sapiens_hsa051100.24375341
91Viral carcinogenesis_Homo sapiens_hsa052030.20145881
92VEGF signaling pathway_Homo sapiens_hsa043700.20032945
93Sphingolipid metabolism_Homo sapiens_hsa006000.19360263
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.17594278
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.17017047
96Insulin resistance_Homo sapiens_hsa049310.16761629
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.16256094
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.13553439
99HTLV-I infection_Homo sapiens_hsa051660.12414733
100FoxO signaling pathway_Homo sapiens_hsa040680.10901267
101Renal cell carcinoma_Homo sapiens_hsa052110.10670979
102Endocytosis_Homo sapiens_hsa041440.10422512
103Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.10147499
104Fatty acid biosynthesis_Homo sapiens_hsa000610.09437641
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.08503612
106MAPK signaling pathway_Homo sapiens_hsa040100.08399882
107MicroRNAs in cancer_Homo sapiens_hsa052060.08038349
108Notch signaling pathway_Homo sapiens_hsa043300.07960730
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.06821260
110Proteasome_Homo sapiens_hsa030500.06693916
111Caffeine metabolism_Homo sapiens_hsa002320.06377557
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.06180175
113Arginine biosynthesis_Homo sapiens_hsa002200.04914996
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.04029077

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