IL1RAPL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the interleukin 1 receptor family. This protein is similar to the interleukin 1 accessory proteins, and is most closely related to interleukin 1 receptor accessory protein-like 1 (IL1RAPL1). This gene and IL1RAPL1 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of light stimulus involved in sensory perception (GO:0050962)6.72749383
2detection of light stimulus involved in visual perception (GO:0050908)6.72749383
3negative regulation of cytosolic calcium ion concentration (GO:0051481)6.26294042
4positive regulation of synapse maturation (GO:0090129)5.96696117
5regulation of DNA methylation (GO:0044030)5.43706072
6cellular potassium ion homeostasis (GO:0030007)5.42193344
7relaxation of smooth muscle (GO:0044557)5.38040539
8G-protein coupled glutamate receptor signaling pathway (GO:0007216)5.35818968
9regulation of acrosome reaction (GO:0060046)5.31892560
10urinary tract smooth muscle contraction (GO:0014848)5.18606638
11neurotransmitter-gated ion channel clustering (GO:0072578)5.13616440
12regulation of synapse maturation (GO:0090128)5.12948756
13synaptic vesicle exocytosis (GO:0016079)5.10012168
14striatum development (GO:0021756)5.09909751
15short-term memory (GO:0007614)5.09698212
16mating behavior (GO:0007617)4.85024841
17piRNA metabolic process (GO:0034587)4.78368962
18retinal cone cell development (GO:0046549)4.76881244
19substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.68390529
20substrate-independent telencephalic tangential migration (GO:0021826)4.68390529
21synaptic vesicle endocytosis (GO:0048488)4.66546070
22regulation of meiosis I (GO:0060631)4.65433547
23lactate metabolic process (GO:0006089)4.64287570
24gamma-aminobutyric acid signaling pathway (GO:0007214)4.62504622
25meiotic cell cycle (GO:0051321)4.58365202
26regulation of dopamine uptake involved in synaptic transmission (GO:0051584)4.54148495
27regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)4.54148495
28regulation of female gonad development (GO:2000194)4.52664354
29negative regulation of circadian rhythm (GO:0042754)4.42543205
30potassium ion homeostasis (GO:0055075)4.40846286
31phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)4.40652351
32prepulse inhibition (GO:0060134)4.38680974
33negative regulation of keratinocyte proliferation (GO:0010839)4.38541019
34synapsis (GO:0007129)4.32088824
35positive regulation of dendritic spine morphogenesis (GO:0061003)4.31654141
36positive regulation of synaptic transmission, glutamatergic (GO:0051968)4.28439794
37dopamine transport (GO:0015872)4.28344291
38regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.26774601
39behavioral response to cocaine (GO:0048148)4.18000247
40positive regulation of glomerulus development (GO:0090193)4.10150638
41multicellular organism reproduction (GO:0032504)4.08343038
42regulation of synaptic vesicle exocytosis (GO:2000300)4.04178933
43synaptic transmission, dopaminergic (GO:0001963)4.03881606
44peristalsis (GO:0030432)4.01464157
45retinal rod cell development (GO:0046548)3.99302779
46DNA methylation involved in gamete generation (GO:0043046)3.97528711
47oocyte development (GO:0048599)3.96331917
48positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.93280634
49sodium ion export (GO:0071436)3.89629306
50regulation of synaptic transmission, glutamatergic (GO:0051966)3.86759934
51long term synaptic depression (GO:0060292)3.86288318
52negative regulation of transcription regulatory region DNA binding (GO:2000678)3.85664875
53protein localization to synapse (GO:0035418)3.84809220
54positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.78804524
55attachment of spindle microtubules to kinetochore (GO:0008608)3.68406478
56regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.67283534
57innervation (GO:0060384)3.62432051
58regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.58001837
59response to histamine (GO:0034776)3.54874275
60response to host (GO:0075136)3.52616434
61response to host defenses (GO:0052200)3.52616434
62response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.52616434
63positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.50734335
64negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.48830114
65positive regulation of CREB transcription factor activity (GO:0032793)3.47082681
66positive regulation of TOR signaling (GO:0032008)3.42744255
67glutamate receptor signaling pathway (GO:0007215)3.42054872
68positive regulation of histone H3-K4 methylation (GO:0051571)3.41467336
69fat-soluble vitamin catabolic process (GO:0042363)3.40390102
70vitamin catabolic process (GO:0009111)3.40390102
71catecholamine transport (GO:0051937)3.40368977
72calcium ion import (GO:0070509)3.39376935
73response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.38310879
74response to host immune response (GO:0052572)3.38310879
75cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.37667809
76neuron-neuron synaptic transmission (GO:0007270)3.37532097
77regulation of neurotransmitter uptake (GO:0051580)3.35253591
78inner ear receptor stereocilium organization (GO:0060122)3.31389798
79chromosome organization involved in meiosis (GO:0070192)3.26531780
80regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.23154177
81regulation of synapse structural plasticity (GO:0051823)3.21007592
82regulation of synaptic vesicle transport (GO:1902803)3.20701896
83vocalization behavior (GO:0071625)3.18984979
84female gamete generation (GO:0007292)3.18238577
85synaptic vesicle transport (GO:0048489)3.18130398
86establishment of synaptic vesicle localization (GO:0097480)3.18130398
87response to pheromone (GO:0019236)3.17222178
88regulation of histone H3-K9 methylation (GO:0051570)3.15634026
89membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.13287186
90genitalia morphogenesis (GO:0035112)3.12404593
91layer formation in cerebral cortex (GO:0021819)3.11460511
92dopamine biosynthetic process (GO:0042416)3.10165500
93positive regulation of gastrulation (GO:2000543)3.08849729
94membrane depolarization during action potential (GO:0086010)3.08115969
95mitotic metaphase plate congression (GO:0007080)3.05340756
96long-term synaptic potentiation (GO:0060291)3.04558785
97cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.03423032
98righting reflex (GO:0060013)3.02400153
99behavioral fear response (GO:0001662)3.02253215
100behavioral defense response (GO:0002209)3.02253215
101synapse assembly (GO:0007416)3.01885912
102proteasome assembly (GO:0043248)3.01741538
103regulation of glutamate receptor signaling pathway (GO:1900449)3.01383324
104dentate gyrus development (GO:0021542)3.01261398
105synaptic vesicle docking involved in exocytosis (GO:0016081)3.00982208
106response to ischemia (GO:0002931)3.00567402
107adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.99304422
108regulation of short-term neuronal synaptic plasticity (GO:0048172)2.98876545
109male meiosis (GO:0007140)2.97214029
110glutamate secretion (GO:0014047)2.95669694
111polyketide metabolic process (GO:0030638)2.94490989
112doxorubicin metabolic process (GO:0044598)2.94490989
113daunorubicin metabolic process (GO:0044597)2.94490989
114detection of molecule of bacterial origin (GO:0032490)2.93955456
115positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.93461014
116neuron fate determination (GO:0048664)2.91224927
117regulation of neurotransmitter transport (GO:0051588)2.91214502
118regulation of calcium ion-dependent exocytosis (GO:0017158)2.88648665
119cochlea development (GO:0090102)2.88449624
120grooming behavior (GO:0007625)2.88115585
121positive regulation of circadian rhythm (GO:0042753)2.86503203
122positive regulation of actin filament depolymerization (GO:0030836)2.86308301
123neuron cell-cell adhesion (GO:0007158)2.85806599
124regulation of vesicle fusion (GO:0031338)2.85804325
125gene silencing by RNA (GO:0031047)2.85284617
126positive regulation of synaptic transmission, GABAergic (GO:0032230)2.85116717
127synaptonemal complex assembly (GO:0007130)2.83625314
128response to auditory stimulus (GO:0010996)2.83100219
129cell communication by electrical coupling (GO:0010644)2.82243844
130negative regulation of oligodendrocyte differentiation (GO:0048715)2.82131855
131primitive streak formation (GO:0090009)2.81502345
132regulation of voltage-gated calcium channel activity (GO:1901385)2.80914847
133synaptic transmission, glutamatergic (GO:0035249)2.79578065
134DNA replication checkpoint (GO:0000076)2.78852769
135regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.78478338
136midgut development (GO:0007494)2.74353798
137regulation of neurotransmitter secretion (GO:0046928)2.73121457
138cellular sodium ion homeostasis (GO:0006883)2.72924761
139regulation of dopamine metabolic process (GO:0042053)2.72415411
140regulation of catecholamine metabolic process (GO:0042069)2.72415411
141centriole replication (GO:0007099)2.70184438
142transmission of nerve impulse (GO:0019226)2.69262257
143regulation of Rac protein signal transduction (GO:0035020)2.65649302
144regulation of keratinocyte proliferation (GO:0010837)2.63719766
145relaxation of cardiac muscle (GO:0055119)2.63571888
146epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.63532532
147negative regulation of reproductive process (GO:2000242)2.63425260
148regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.62973947
149male meiosis I (GO:0007141)2.59655779
150regulation of mitotic spindle checkpoint (GO:1903504)2.58876787
151regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.58876787
152regulation of Rac GTPase activity (GO:0032314)2.58625427
153regulation of cell maturation (GO:1903429)2.58357469
154negative regulation of complement activation (GO:0045916)2.58321175
155response to cocaine (GO:0042220)2.57478724
156retina layer formation (GO:0010842)2.57219337
157protein localization to kinetochore (GO:0034501)2.54350576
158positive regulation of chromosome segregation (GO:0051984)2.54252253
159regulation of glomerulus development (GO:0090192)2.53688654
160metaphase plate congression (GO:0051310)2.51369490
161protein polyglutamylation (GO:0018095)2.51148872
162protein localization to chromosome (GO:0034502)2.50268953
163ectoderm development (GO:0007398)2.50167834
164protein heterotetramerization (GO:0051290)2.49195437
165regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.48132172
166synaptonemal complex organization (GO:0070193)2.47175578
167regulation of steroid hormone secretion (GO:2000831)2.47067125
168anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.46265075
169regulation of amino acid transport (GO:0051955)2.43684022
170aggressive behavior (GO:0002118)2.43317829
171positive regulation of meiosis (GO:0045836)2.43016427
172positive regulation of hormone biosynthetic process (GO:0046886)2.40460790
173reproductive system development (GO:0061458)2.40031523
174N-terminal protein amino acid acetylation (GO:0006474)2.38792783
175negative regulation of protein activation cascade (GO:2000258)2.38123967
176reproduction (GO:0000003)2.38031153
177eye photoreceptor cell development (GO:0042462)2.36897217
178binding of sperm to zona pellucida (GO:0007339)2.34944871
179fertilization (GO:0009566)2.32003443
180long-chain fatty acid biosynthetic process (GO:0042759)2.31889972
181hematopoietic stem cell proliferation (GO:0071425)2.31547127
182response to follicle-stimulating hormone (GO:0032354)2.28435015
183regulation of meiosis (GO:0040020)2.27382264
184filopodium assembly (GO:0046847)2.26990767
185photoreceptor cell development (GO:0042461)2.26909261
186exploration behavior (GO:0035640)2.26904060
187anterior/posterior axis specification, embryo (GO:0008595)2.26450286
188glycine transport (GO:0015816)2.26168656
189metanephric nephron tubule development (GO:0072234)2.25650580

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.37621610
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.37772629
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.20499408
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.72793533
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.66695596
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.52653879
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.51682735
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.38757076
9* TAF15_26573619_Chip-Seq_HEK293_Human2.34063528
10E2F7_22180533_ChIP-Seq_HELA_Human2.32097116
11REST_21632747_ChIP-Seq_MESCs_Mouse2.31191784
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.30919366
13EZH2_22144423_ChIP-Seq_EOC_Human2.30763664
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.30501705
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.30489360
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.21786522
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.13962937
18BMI1_23680149_ChIP-Seq_NPCS_Mouse2.13454253
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.10753851
20* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.09823065
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.08697220
22CTBP2_25329375_ChIP-Seq_LNCAP_Human2.07762305
23AR_21572438_ChIP-Seq_LNCaP_Human2.05120677
24* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.04925711
25P300_19829295_ChIP-Seq_ESCs_Human2.04113376
26* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.00307941
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.00012409
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.99064362
29EZH2_18974828_ChIP-Seq_MESCs_Mouse1.97643828
30RNF2_18974828_ChIP-Seq_MESCs_Mouse1.97643828
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.96252202
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.94534996
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.91824125
34* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.89238890
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88342814
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.87716826
37SMAD4_21799915_ChIP-Seq_A2780_Human1.86821626
38DROSHA_22980978_ChIP-Seq_HELA_Human1.86672975
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.83180191
40BCAT_22108803_ChIP-Seq_LS180_Human1.79794274
41E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.78388472
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.76150182
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72589310
44EWS_26573619_Chip-Seq_HEK293_Human1.72086945
45SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.67602386
46FOXM1_26456572_ChIP-Seq_MCF-7_Human1.66940299
47* FUS_26573619_Chip-Seq_HEK293_Human1.64177930
48IRF8_21731497_ChIP-ChIP_J774_Mouse1.62364749
49* PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.61441690
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.61204800
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.60995235
52REST_18959480_ChIP-ChIP_MESCs_Mouse1.60235489
53P53_22127205_ChIP-Seq_FIBROBLAST_Human1.59823745
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.58488178
55RNF2_27304074_Chip-Seq_NSC_Mouse1.57919030
56CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.55587269
57NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.55543418
58IGF1R_20145208_ChIP-Seq_DFB_Human1.54745949
59CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.52229228
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50422055
61CBP_20019798_ChIP-Seq_JUKART_Human1.50422055
62KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.49842595
63KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.49842595
64KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.49842595
65FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.47078768
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46394854
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45455016
68AR_25329375_ChIP-Seq_VCAP_Human1.44995188
69* AHR_22903824_ChIP-Seq_MCF-7_Human1.42657524
70EP300_21415370_ChIP-Seq_HL-1_Mouse1.42626692
71GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.37671816
72KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.37026566
73CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.35792000
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35704673
75HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.34200417
76PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.33146044
77TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.31726420
78CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31129420
79RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30866726
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.30829853
81TCF4_22108803_ChIP-Seq_LS180_Human1.29022038
82SALL1_21062744_ChIP-ChIP_HESCs_Human1.28340783
83ER_23166858_ChIP-Seq_MCF-7_Human1.27334391
84ESR1_20079471_ChIP-ChIP_T-47D_Human1.25703870
85EGR1_19374776_ChIP-ChIP_THP-1_Human1.24580032
86NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.24321331
87STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.24118424
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23933998
89* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23700779
90* TCF4_23295773_ChIP-Seq_U87_Human1.21983760
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21224592
92TP53_18474530_ChIP-ChIP_U2OS_Human1.21094589
93CMYC_18555785_Chip-Seq_ESCs_Mouse1.20453074
94SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19848903
95E2F1_18555785_Chip-Seq_ESCs_Mouse1.18333007
96IRF8_22096565_ChIP-ChIP_GC-B_Human1.18182311
97POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18065599
98* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17978102
99TP63_19390658_ChIP-ChIP_HaCaT_Human1.17919394
100TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17828158
101* ARNT_22903824_ChIP-Seq_MCF-7_Human1.17156357
102CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.17095514
103* STAT3_23295773_ChIP-Seq_U87_Human1.16973384
104UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16688005
105TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16634299
106RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.16510150
107IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.14701857
108NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14695901
109BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14178338
110JUN_21703547_ChIP-Seq_K562_Human1.13603860
111RARB_27405468_Chip-Seq_BRAIN_Mouse1.12838768
112MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12632533
113LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11914723
114P53_22387025_ChIP-Seq_ESCs_Mouse1.11688438
115RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10915967
116NANOG_19829295_ChIP-Seq_ESCs_Human1.09791121
117SOX2_19829295_ChIP-Seq_ESCs_Human1.09791121
118FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.09665041
119TP53_16413492_ChIP-PET_HCT116_Human1.09572396
120TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09434120
121STAT3_18555785_Chip-Seq_ESCs_Mouse1.08754423
122* SOX2_21211035_ChIP-Seq_LN229_Gbm1.08469825
123ZNF274_21170338_ChIP-Seq_K562_Hela1.07848637
124E2F4_17652178_ChIP-ChIP_JURKAT_Human1.07382985
125TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06977342
126SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06341085
127PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05671131
128KDM2B_26808549_Chip-Seq_REH_Human1.04202506
129EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03038644
130PRDM14_20953172_ChIP-Seq_ESCs_Human1.02347557
131TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02138137
132SOX2_18555785_Chip-Seq_ESCs_Mouse1.02027926
133* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01269439
134VDR_22108803_ChIP-Seq_LS180_Human1.01074746
135RUNX1_27457419_Chip-Seq_LIVER_Mouse1.00557486
136NOTCH1_21737748_ChIP-Seq_TLL_Human1.00191294
137OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99767949
138FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99376589
139FLI1_27457419_Chip-Seq_LIVER_Mouse0.99167313
140NMYC_18555785_Chip-Seq_ESCs_Mouse0.98955935
141SMAD4_21741376_ChIP-Seq_EPCs_Human0.98383834
142KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98114513
143FLI1_21867929_ChIP-Seq_TH2_Mouse0.97684131
144CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96862173
145KLF4_18555785_Chip-Seq_ESCs_Mouse0.96489255
146EZH2_27294783_Chip-Seq_NPCs_Mouse0.96264211
147P300_18555785_Chip-Seq_ESCs_Mouse0.95981435
148BP1_19119308_ChIP-ChIP_Hs578T_Human0.95456266
149FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94584191
150PU1_27457419_Chip-Seq_LIVER_Mouse0.94491860
151NFE2_27457419_Chip-Seq_LIVER_Mouse0.94195702
152AR_21909140_ChIP-Seq_LNCAP_Human0.94171882
153* RUNX2_22187159_ChIP-Seq_PCA_Human0.94163387
154ZFX_18555785_Chip-Seq_ESCs_Mouse0.94149791
155SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93509241
156HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.92712395
157MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91194362
158NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.90619772

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect4.93254547
2MP0006292_abnormal_olfactory_placode4.29996022
3MP0005551_abnormal_eye_electrophysiolog3.86827365
4MP0010386_abnormal_urinary_bladder3.57822632
5MP0003880_abnormal_central_pattern3.57430546
6MP0001502_abnormal_circadian_rhythm3.19268198
7MP0002090_abnormal_vision3.19250558
8MP0008877_abnormal_DNA_methylation3.12422828
9MP0001188_hyperpigmentation2.99193808
10MP0009046_muscle_twitch2.94224647
11MP0004859_abnormal_synaptic_plasticity2.72380246
12MP0001984_abnormal_olfaction2.70107717
13MP0005395_other_phenotype2.57459199
14MP0005187_abnormal_penis_morphology2.56583999
15MP0006072_abnormal_retinal_apoptosis2.56407991
16MP0004233_abnormal_muscle_weight2.42623173
17MP0003635_abnormal_synaptic_transmissio2.39429535
18MP0010234_abnormal_vibrissa_follicle2.34074675
19MP0002282_abnormal_trachea_morphology2.31294801
20MP0004782_abnormal_surfactant_physiolog2.23359783
21MP0002736_abnormal_nociception_after2.22472957
22MP0002064_seizures2.18059371
23MP0001849_ear_inflammation2.16687206
24MP0002638_abnormal_pupillary_reflex2.12344878
25MP0001968_abnormal_touch/_nociception2.11409963
26MP0005394_taste/olfaction_phenotype2.08935356
27MP0005499_abnormal_olfactory_system2.08935356
28MP0002067_abnormal_sensory_capabilities2.07341905
29MP0009745_abnormal_behavioral_response2.05329846
30MP0010307_abnormal_tumor_latency2.05198838
31MP0002063_abnormal_learning/memory/cond2.01222174
32MP0008995_early_reproductive_senescence1.98583778
33MP0003950_abnormal_plasma_membrane1.98113913
34MP0008789_abnormal_olfactory_epithelium1.95813008
35MP0002184_abnormal_innervation1.93694623
36MP0001501_abnormal_sleep_pattern1.93025611
37MP0001486_abnormal_startle_reflex1.91204381
38MP0002272_abnormal_nervous_system1.86755755
39MP0005248_abnormal_Harderian_gland1.84752048
40MP0008875_abnormal_xenobiotic_pharmacok1.84068910
41MP0001529_abnormal_vocalization1.83053920
42MP0003879_abnormal_hair_cell1.79216985
43MP0002572_abnormal_emotion/affect_behav1.78380639
44MP0002234_abnormal_pharynx_morphology1.69000331
45MP0001346_abnormal_lacrimal_gland1.65536177
46MP0005253_abnormal_eye_physiology1.60238431
47MP0006276_abnormal_autonomic_nervous1.59466077
48MP0005195_abnormal_posterior_eye1.58477020
49MP0003787_abnormal_imprinting1.58395175
50MP0010030_abnormal_orbit_morphology1.56553809
51MP0002822_catalepsy1.56212184
52MP0005410_abnormal_fertilization1.55650809
53MP0002735_abnormal_chemical_nociception1.54755691
54MP0000427_abnormal_hair_cycle1.48590663
55MP0004036_abnormal_muscle_relaxation1.46701969
56MP0002332_abnormal_exercise_endurance1.46289239
57MP0002148_abnormal_hypersensitivity_rea1.45888492
58MP0000579_abnormal_nail_morphology1.45195613
59MP0008260_abnormal_autophagy1.44308233
60MP0002734_abnormal_mechanical_nocicepti1.43940305
61MP0003868_abnormal_feces_composition1.43800413
62MP0003693_abnormal_embryo_hatching1.39831140
63MP0002277_abnormal_respiratory_mucosa1.39526329
64MP0002233_abnormal_nose_morphology1.37955279
65MP0003941_abnormal_skin_development1.36590465
66MP0008057_abnormal_DNA_replication1.36252560
67MP0008775_abnormal_heart_ventricle1.35648357
68MP0003786_premature_aging1.34499709
69MP0010678_abnormal_skin_adnexa1.32895947
70MP0000647_abnormal_sebaceous_gland1.31969695
71MP0003943_abnormal_hepatobiliary_system1.29356694
72MP0003699_abnormal_female_reproductive1.28682782
73MP0008932_abnormal_embryonic_tissue1.27260232
74MP0005645_abnormal_hypothalamus_physiol1.26815067
75MP0008569_lethality_at_weaning1.26570019
76MP0004742_abnormal_vestibular_system1.23213501
77MP0000631_abnormal_neuroendocrine_gland1.23078012
78MP0005646_abnormal_pituitary_gland1.19927253
79MP0003121_genomic_imprinting1.18862621
80MP0009785_altered_susceptibility_to1.17096450
81MP0001929_abnormal_gametogenesis1.15994303
82MP0002557_abnormal_social/conspecific_i1.15850552
83MP0002163_abnormal_gland_morphology1.15707774
84MP0002229_neurodegeneration1.14930634
85MP0003937_abnormal_limbs/digits/tail_de1.14688293
86MP0001835_abnormal_antigen_presentation1.13757860
87MP0001177_atelectasis1.13429603
88MP0002751_abnormal_autonomic_nervous1.13028248
89MP0002752_abnormal_somatic_nervous1.09750345
90MP0004215_abnormal_myocardial_fiber1.09072835
91MP0003183_abnormal_peptide_metabolism1.08761810
92MP0005389_reproductive_system_phenotype1.07022621
93MP0000613_abnormal_salivary_gland1.06360405
94MP0009697_abnormal_copulation1.06286838
95MP0005595_abnormal_vascular_smooth1.06057135
96MP0009764_decreased_sensitivity_to1.04539987
97MP0003077_abnormal_cell_cycle1.04064407
98MP0000762_abnormal_tongue_morphology1.03958273
99MP0000383_abnormal_hair_follicle1.03361786
100MP0002138_abnormal_hepatobiliary_system1.03348956
101MP0008058_abnormal_DNA_repair1.01856388
102MP0002210_abnormal_sex_determination1.01504619
103MP0002882_abnormal_neuron_morphology1.00019435
104MP0001919_abnormal_reproductive_system0.97381992
105MP0005310_abnormal_salivary_gland0.96774891
106MP0004142_abnormal_muscle_tone0.96460137
107MP0001970_abnormal_pain_threshold0.95047253
108MP0005386_behavior/neurological_phenoty0.94887318
109MP0004924_abnormal_behavior0.94887318
110MP0001440_abnormal_grooming_behavior0.94481565
111MP0000534_abnormal_ureter_morphology0.93728158
112MP0005220_abnormal_exocrine_pancreas0.92964843
113MP0008961_abnormal_basal_metabolism0.91171765
114MP0004084_abnormal_cardiac_muscle0.91118895
115MP0005423_abnormal_somatic_nervous0.90675102
116MP0003755_abnormal_palate_morphology0.90136151
117MP0000566_synostosis0.87129530
118MP0004147_increased_porphyrin_level0.86899373
119MP0000377_abnormal_hair_follicle0.85687844
120MP0002161_abnormal_fertility/fecundity0.85409033
121MP0000653_abnormal_sex_gland0.84819499
122MP0004270_analgesia0.84712338
123MP0006054_spinal_hemorrhage0.84454494
124MP0005671_abnormal_response_to0.84428638
125MP0006082_CNS_inflammation0.83853701
126MP0004811_abnormal_neuron_physiology0.82639472
127MP0000537_abnormal_urethra_morphology0.81816312
128MP0003172_abnormal_lysosome_physiology0.81480168
129MP0003646_muscle_fatigue0.81459894
130MP0001324_abnormal_eye_pigmentation0.80949227
131MP0005379_endocrine/exocrine_gland_phen0.80781729
132MP0010094_abnormal_chromosome_stability0.80111623
133MP0000538_abnormal_urinary_bladder0.79914137
134MP0002102_abnormal_ear_morphology0.79797818
135MP0002160_abnormal_reproductive_system0.79794358
136MP0008872_abnormal_physiological_respon0.78867136
137MP0001664_abnormal_digestion0.75959454
138MP0002098_abnormal_vibrissa_morphology0.75779008
139MP0002089_abnormal_postnatal_growth/wei0.75657607
140MP0004085_abnormal_heartbeat0.75404630
141MP0002066_abnormal_motor_capabilities/c0.75081963
142MP0000049_abnormal_middle_ear0.74598384
143MP0006035_abnormal_mitochondrial_morpho0.74467452
144MP0001119_abnormal_female_reproductive0.73470175
145MP0005387_immune_system_phenotype0.73433358
146MP0001790_abnormal_immune_system0.73433358
147MP0008004_abnormal_stomach_pH0.73145842
148MP0000733_abnormal_muscle_development0.72840691
149MP0003122_maternal_imprinting0.72568697
150MP0001905_abnormal_dopamine_level0.72380084
151MP0000778_abnormal_nervous_system0.72068966
152MP0004043_abnormal_pH_regulation0.71507512
153MP0003890_abnormal_embryonic-extraembry0.69464271
154MP0000955_abnormal_spinal_cord0.68129694
155MP0000569_abnormal_digit_pigmentation0.67985269
156MP0005535_abnormal_body_temperature0.67298343
157MP0002876_abnormal_thyroid_physiology0.66656318
158MP0004510_myositis0.66481571
159MP0001963_abnormal_hearing_physiology0.65616716
160MP0003633_abnormal_nervous_system0.64038131

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)9.63343635
2Severe visual impairment (HP:0001141)6.99747343
3Central scotoma (HP:0000603)6.07056943
4Abnormality of macular pigmentation (HP:0008002)5.93816329
5Septo-optic dysplasia (HP:0100842)5.41522316
6Epileptic encephalopathy (HP:0200134)5.28501712
7Febrile seizures (HP:0002373)4.97011048
8Absence seizures (HP:0002121)4.63331943
9Hypoplasia of the fovea (HP:0007750)4.61858011
10Aplasia/Hypoplasia of the fovea (HP:0008060)4.61858011
11Albinism (HP:0001022)4.32365813
12Dialeptic seizures (HP:0011146)4.07305923
13Male infertility (HP:0003251)3.86145775
14Abnormality of the fovea (HP:0000493)3.69290209
15Supernumerary spleens (HP:0009799)3.64999360
16Scotoma (HP:0000575)3.57558672
17Focal motor seizures (HP:0011153)3.55233440
18Spontaneous abortion (HP:0005268)3.49541502
19Abnormal rod and cone electroretinograms (HP:0008323)3.49114551
20Increased IgM level (HP:0003496)3.48811202
21Optic nerve hypoplasia (HP:0000609)3.35183435
22Generalized tonic-clonic seizures (HP:0002069)3.23103150
23Abnormality of the labia minora (HP:0012880)3.22939228
24Keratoconus (HP:0000563)3.20846307
25Increased corneal curvature (HP:0100692)3.20846307
26Cerebellar dysplasia (HP:0007033)3.19852092
27Abnormal pupillary function (HP:0007686)3.19002749
28Progressive cerebellar ataxia (HP:0002073)3.17126442
29Infertility (HP:0000789)3.11268667
30Deep philtrum (HP:0002002)3.07206501
31Increased number of teeth (HP:0011069)3.03785024
32Oligodactyly (hands) (HP:0001180)3.03082945
33Generalized hypopigmentation (HP:0007513)2.94040528
34Cholecystitis (HP:0001082)2.87950500
35Abnormal gallbladder physiology (HP:0012438)2.87950500
36Hypophosphatemic rickets (HP:0004912)2.87796840
37Aplasia/Hypoplasia of the macula (HP:0008059)2.87501881
38Abnormal hair whorl (HP:0010721)2.85455931
39Action tremor (HP:0002345)2.83935710
40Facial hemangioma (HP:0000329)2.82283887
41Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.79892681
42Hemiparesis (HP:0001269)2.75944904
43Hypokinesia (HP:0002375)2.73343973
44Epileptiform EEG discharges (HP:0011182)2.71182601
45Partial agenesis of the corpus callosum (HP:0001338)2.70356895
46EEG with generalized epileptiform discharges (HP:0011198)2.67219139
47Bifid tongue (HP:0010297)2.66559759
48Tubulointerstitial nephritis (HP:0001970)2.64005090
49Absent septum pellucidum (HP:0001331)2.61213169
50Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.60817903
51Chronic sinusitis (HP:0011109)2.54983747
52Retinal dysplasia (HP:0007973)2.54321147
53Labial hypoplasia (HP:0000066)2.52257123
54Aplasia/Hypoplasia affecting the retina (HP:0008061)2.49673464
55Abnormality of the astrocytes (HP:0100707)2.47881873
56Astrocytoma (HP:0009592)2.47881873
57True hermaphroditism (HP:0010459)2.46023431
58Abnormality of the labia (HP:0000058)2.45587638
59Papillary thyroid carcinoma (HP:0002895)2.45547986
60Abnormality of the septum pellucidum (HP:0007375)2.44869531
61Lip pit (HP:0100267)2.43602195
62Atonic seizures (HP:0010819)2.42301752
63Cutaneous finger syndactyly (HP:0010554)2.41889761
64Prolonged QT interval (HP:0001657)2.41551710
65Abnormality of lateral ventricle (HP:0030047)2.39975527
66Diastasis recti (HP:0001540)2.39818214
67Dysdiadochokinesis (HP:0002075)2.39452802
68Abnormality of abdominal situs (HP:0011620)2.36680071
69Abdominal situs inversus (HP:0003363)2.36680071
70Hypoplastic female external genitalia (HP:0012815)2.35075831
71Gonadotropin excess (HP:0000837)2.33903291
72Concave nail (HP:0001598)2.33028952
73Short hallux (HP:0010109)2.31837202
74Increased intramyocellular lipid droplets (HP:0012240)2.31757660
75Azoospermia (HP:0000027)2.26958220
76Osteomalacia (HP:0002749)2.23543718
77Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.23249939
78Spastic diplegia (HP:0001264)2.20388410
79Abnormality of the parathyroid morphology (HP:0011766)2.20070998
80Focal seizures (HP:0007359)2.18780071
81Oligodactyly (HP:0012165)2.17471665
82Hypoplastic labia majora (HP:0000059)2.16429641
83Chronic hepatic failure (HP:0100626)2.16108536
84Decreased central vision (HP:0007663)2.15977987
85Horizontal nystagmus (HP:0000666)2.15619615
86Dynein arm defect of respiratory motile cilia (HP:0012255)2.15013295
87Absent/shortened dynein arms (HP:0200106)2.15013295
88Myokymia (HP:0002411)2.12200549
89Glioma (HP:0009733)2.10407390
90Poikiloderma (HP:0001029)2.08277244
91X-linked dominant inheritance (HP:0001423)2.06352085
92Aplasia/Hypoplasia of the tongue (HP:0010295)2.05867452
93Cutaneous syndactyly (HP:0012725)2.05117104
94Aplasia/Hypoplasia of the hallux (HP:0008362)2.04298464
95Mutism (HP:0002300)2.03701885
96Gait imbalance (HP:0002141)2.03592860
97Ileus (HP:0002595)2.03118140
98Lissencephaly (HP:0001339)2.02300360
99Conjunctival telangiectasia (HP:0000524)2.01823037
100Atrial fibrillation (HP:0005110)2.01157884
101Congenital primary aphakia (HP:0007707)2.00960868
102Rhabdomyosarcoma (HP:0002859)2.00386742
103Gaze-evoked nystagmus (HP:0000640)2.00240657
104Medial flaring of the eyebrow (HP:0010747)1.99183602
105Hypoplastic left heart (HP:0004383)1.97468525
106Nephrogenic diabetes insipidus (HP:0009806)1.96953940
107Median cleft lip (HP:0000161)1.96366605
108Scanning speech (HP:0002168)1.95814558
109Abnormality of the labia majora (HP:0012881)1.95390585
110Abnormal EKG (HP:0003115)1.93660196
111Pheochromocytoma (HP:0002666)1.92875529
112Abnormality of aromatic amino acid family metabolism (HP:0004338)1.92157691
113Widely spaced teeth (HP:0000687)1.91204706
114Chin dimple (HP:0010751)1.91015202
115Abnormal tarsal ossification (HP:0008369)1.90771353
116Type II lissencephaly (HP:0007260)1.90162206
117Severe Myopia (HP:0011003)1.90155565
118Renal Fanconi syndrome (HP:0001994)1.89062651
119Polyphagia (HP:0002591)1.88449875
120Dysmetric saccades (HP:0000641)1.88287688
121Stenosis of the external auditory canal (HP:0000402)1.88182326
122Coronal craniosynostosis (HP:0004440)1.87012774
123Depressed nasal tip (HP:0000437)1.86757906
124Alopecia of scalp (HP:0002293)1.85846115
125Abnormality of the epiphyses of the hand (HP:0005924)1.83206947
126Increased neuronal autofluorescent lipopigment (HP:0002074)1.82974308
127Primary atrial arrhythmia (HP:0001692)1.81644694
128Chronic mucocutaneous candidiasis (HP:0002728)1.80285439
129Recurrent cutaneous fungal infections (HP:0011370)1.80285439
130Pancreatic fibrosis (HP:0100732)1.79961637
131Bifid scrotum (HP:0000048)1.79827070
132Fragile nails (HP:0001808)1.78056449
133Hyperventilation (HP:0002883)1.77889954
134Abolished electroretinogram (ERG) (HP:0000550)1.77371786
135Abnormality of midbrain morphology (HP:0002418)1.77269229
136Molar tooth sign on MRI (HP:0002419)1.77269229
137Abnormality of the proximal phalanges of the hand (HP:0009834)1.76457575
138Posterior subcapsular cataract (HP:0007787)1.76304437
139Visual hallucinations (HP:0002367)1.76210877
140Choroideremia (HP:0001139)1.76047712
141Increased hepatocellular lipid droplets (HP:0006565)1.75954943
142Tracheal stenosis (HP:0002777)1.75422949
143Increased muscle lipid content (HP:0009058)1.75084972
144Abnormality of the clitoris (HP:0000056)1.74692341
145Excessive salivation (HP:0003781)1.74614513
146Drooling (HP:0002307)1.74614513
147Duplicated collecting system (HP:0000081)1.74370268
148Astigmatism (HP:0000483)1.74219193
149Intrahepatic cholestasis (HP:0001406)1.73971091
150Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.73931248
151Overlapping toe (HP:0001845)1.73391622
152Postural tremor (HP:0002174)1.73308280
153Neuroendocrine neoplasm (HP:0100634)1.73186288
154Broad foot (HP:0001769)1.72347444
155Short middle phalanx of the 5th finger (HP:0004220)1.71582046
156Pulmonary artery stenosis (HP:0004415)1.71466937
157Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.70906386
158Abnormality of alanine metabolism (HP:0010916)1.70906386
159Hyperalaninemia (HP:0003348)1.70906386
160Fetal akinesia sequence (HP:0001989)1.70087891
161Abnormality of renal resorption (HP:0011038)1.69940329
162Supraventricular tachycardia (HP:0004755)1.69785303
163Exercise-induced myalgia (HP:0003738)1.69669549
164Syncope (HP:0001279)1.69471659
165Renal hypoplasia (HP:0000089)1.68322893
166Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.67354715
167Wide intermamillary distance (HP:0006610)1.67202741
168Entropion (HP:0000621)1.66568341
169Short 4th metacarpal (HP:0010044)1.66455255
170Gingivitis (HP:0000230)1.64711582
171Hypsarrhythmia (HP:0002521)1.63343560
172Depression (HP:0000716)1.61883979
173Incomplete penetrance (HP:0003829)1.61840583
174Maternal diabetes (HP:0009800)1.61673138
175Parakeratosis (HP:0001036)1.61017327
176Anxiety (HP:0000739)1.60119018
177Supraventricular arrhythmia (HP:0005115)1.59059004
178Limb dystonia (HP:0002451)1.58594360

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK8.38693412
2LMTK23.97712063
3MAP3K133.90424136
4NUAK13.22870460
5MAP3K43.05734484
6MST42.87340465
7NME12.84919214
8MAP3K92.81983892
9STK242.79778967
10CASK2.50315805
11EPHA42.46556242
12EIF2AK32.33330239
13STK392.20171542
14ARAF2.17951379
15MAP4K22.16235790
16PAK62.15268838
17TXK1.96812237
18MAP2K71.95890839
19MAP3K141.91843611
20TTK1.91537689
21MET1.88756939
22FES1.87209946
23DMPK1.85674097
24BRSK21.84948080
25PNCK1.66028036
26RIPK41.63464884
27IRAK31.61060839
28SIK31.60295402
29STK38L1.58415379
30ICK1.57038638
31ILK1.56690247
32OXSR11.56107451
33CSNK1G31.55275949
34MAP3K121.51954988
35CDK31.47423806
36CSNK1G11.46139437
37TNIK1.43783411
38MINK11.42326342
39CCNB11.40664593
40PRPF4B1.36714710
41PRKCI1.34524569
42CSNK1A1L1.31897651
43BMPR21.27303780
44CSNK1G21.25542568
45INSRR1.25184925
46CDC71.19954960
47ADRBK21.18342536
48NEK11.16821665
49BUB11.15894780
50NTRK31.15819959
51SIK21.13266803
52CDK81.12492098
53FER1.10223706
54MARK11.09797988
55MKNK21.09697796
56STK381.08835100
57TRIM281.07842005
58AKT31.07735371
59CAMK2D1.05585543
60DYRK1A1.04788374
61BRSK11.01818595
62BRAF1.01564168
63YES11.01559959
64IRAK21.01400524
65MAP2K40.94548270
66MST1R0.94108969
67PTK20.90750596
68ERBB30.89738736
69PHKG10.88759597
70PHKG20.88759597
71NTRK20.86940936
72PLK10.85902422
73TLK10.85368831
74PRKD30.83528349
75MAPK130.80336289
76PRKCE0.79654600
77PLK30.76124138
78MAPKAPK30.75052900
79STK30.73803509
80EIF2AK20.73476185
81PAK40.73331918
82MUSK0.72885454
83PLK20.72175050
84GRK70.72116735
85CSNK1D0.70933207
86CAMK2A0.69574667
87PLK40.67933707
88BLK0.67536982
89DAPK20.67356576
90AURKA0.67205081
91VRK20.66872306
92CAMK10.66220176
93MAP3K70.65963361
94TYK20.64945251
95KSR20.63348596
96TSSK60.62854576
97BCR0.62835862
98ROCK10.58803827
99PINK10.57621047
100MAP3K60.57430226
101CHEK20.56764115
102PRKCG0.56197032
103WNK30.56160197
104SGK2230.55139495
105SGK4940.55139495
106GRK50.53491568
107KSR10.53401828
108TNK20.53398755
109NEK60.52831694
110STK160.52194548
111CDK50.52073213
112CDK90.51455304
113ZAK0.50660233
114JAK30.50182460
115IKBKB0.50141840
116MOS0.49989285
117CSNK1E0.49510225
118PRKAA10.49061799
119CDK70.47881476
120SYK0.46991094
121SGK20.45930946
122PRKG20.44698329
123IRAK40.43923025
124RAF10.43873443
125PAK30.43327436
126PIK3CG0.42883063
127ATM0.42017838
128FLT30.40884633
129DAPK10.39700911
130ATR0.38968173
131LYN0.38076936
132PRKCA0.38001909
133PKN10.36741991
134WEE10.36690876
135BRD40.35353233
136PRKCB0.35283751
137PRKACA0.34811680
138ROCK20.34722075
139EPHB20.34701711
140TBK10.34313366
141PRKG10.33458604
142PRKCQ0.32485581
143MAP2K10.32324588
144JAK10.31369237
145PRKCD0.30658444
146TIE10.30597956
147MYLK0.29970459
148LATS10.28840628
149SGK10.28819192
150PRKACB0.28762673
151KIT0.28527428
152CDK140.27202776
153IKBKE0.26873184
154WNK40.26517899
155CAMK2B0.26370283
156RIPK10.25813667
157MAPKAPK50.25307076
158EPHA30.23394292
159PRKCZ0.23029365
160VRK10.22484791
161PRKCH0.22292000
162HCK0.22160691

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.41555282
2Caffeine metabolism_Homo sapiens_hsa002323.83434994
3Synaptic vesicle cycle_Homo sapiens_hsa047213.74231825
4GABAergic synapse_Homo sapiens_hsa047273.47431544
5Morphine addiction_Homo sapiens_hsa050323.28941989
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.23528738
7Proteasome_Homo sapiens_hsa030502.89752521
8Nitrogen metabolism_Homo sapiens_hsa009102.67900167
9Circadian entrainment_Homo sapiens_hsa047132.48938594
10Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.47088923
11Protein export_Homo sapiens_hsa030602.39855322
12Olfactory transduction_Homo sapiens_hsa047402.29320608
13Collecting duct acid secretion_Homo sapiens_hsa049662.28715532
14Cell cycle_Homo sapiens_hsa041102.17890058
15Basal transcription factors_Homo sapiens_hsa030222.14655387
16Serotonergic synapse_Homo sapiens_hsa047262.00621709
17Oocyte meiosis_Homo sapiens_hsa041141.99750425
18Insulin secretion_Homo sapiens_hsa049111.93329382
19Circadian rhythm_Homo sapiens_hsa047101.90241477
20Glutamatergic synapse_Homo sapiens_hsa047241.89726925
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.81318847
22Graft-versus-host disease_Homo sapiens_hsa053321.77178000
23Renin secretion_Homo sapiens_hsa049241.75757541
24Taste transduction_Homo sapiens_hsa047421.70052001
25Rheumatoid arthritis_Homo sapiens_hsa053231.68194344
26Autoimmune thyroid disease_Homo sapiens_hsa053201.67601343
27Salivary secretion_Homo sapiens_hsa049701.66320449
28Allograft rejection_Homo sapiens_hsa053301.60166797
29Cholinergic synapse_Homo sapiens_hsa047251.58778851
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.53104931
31Type I diabetes mellitus_Homo sapiens_hsa049401.45010333
32Fanconi anemia pathway_Homo sapiens_hsa034601.44529547
33Mismatch repair_Homo sapiens_hsa034301.44304584
34Dopaminergic synapse_Homo sapiens_hsa047281.41730573
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.40613430
36Fructose and mannose metabolism_Homo sapiens_hsa000511.39181415
37RNA degradation_Homo sapiens_hsa030181.36097444
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.34349606
39Calcium signaling pathway_Homo sapiens_hsa040201.33784774
40RNA polymerase_Homo sapiens_hsa030201.33474423
41Toll-like receptor signaling pathway_Homo sapiens_hsa046201.28756517
42Nucleotide excision repair_Homo sapiens_hsa034201.26263714
43Steroid biosynthesis_Homo sapiens_hsa001001.25536526
44Cocaine addiction_Homo sapiens_hsa050301.22973535
45Cardiac muscle contraction_Homo sapiens_hsa042601.22658295
46Fatty acid elongation_Homo sapiens_hsa000621.18007002
47Oxytocin signaling pathway_Homo sapiens_hsa049211.12902581
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.12719286
49Ovarian steroidogenesis_Homo sapiens_hsa049131.08285463
50Regulation of autophagy_Homo sapiens_hsa041401.08181541
51Huntingtons disease_Homo sapiens_hsa050161.07027168
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.05012420
53Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.04763770
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03871910
55Parkinsons disease_Homo sapiens_hsa050121.01042810
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.00290607
57Amphetamine addiction_Homo sapiens_hsa050311.00214320
58Type II diabetes mellitus_Homo sapiens_hsa049300.99034764
59Aldosterone synthesis and secretion_Homo sapiens_hsa049250.97922851
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.97109763
61Retinol metabolism_Homo sapiens_hsa008300.97042315
62cAMP signaling pathway_Homo sapiens_hsa040240.96838716
63Homologous recombination_Homo sapiens_hsa034400.96631607
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95661247
65African trypanosomiasis_Homo sapiens_hsa051430.94020007
66Hippo signaling pathway_Homo sapiens_hsa043900.89571146
67Thyroid cancer_Homo sapiens_hsa052160.89122973
68Mineral absorption_Homo sapiens_hsa049780.88803074
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.87689309
70RNA transport_Homo sapiens_hsa030130.87514493
71Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.86379055
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.86352064
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86281385
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86072190
75Sphingolipid metabolism_Homo sapiens_hsa006000.85523122
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83486517
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82400228
78p53 signaling pathway_Homo sapiens_hsa041150.80844542
79Base excision repair_Homo sapiens_hsa034100.80722898
80Vibrio cholerae infection_Homo sapiens_hsa051100.80253741
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80235700
82Dilated cardiomyopathy_Homo sapiens_hsa054140.79934943
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79370473
84DNA replication_Homo sapiens_hsa030300.79342984
85N-Glycan biosynthesis_Homo sapiens_hsa005100.78753372
86Tight junction_Homo sapiens_hsa045300.78687279
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77707087
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.77432184
89Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.77395131
90Gap junction_Homo sapiens_hsa045400.77052878
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75832062
92Long-term depression_Homo sapiens_hsa047300.75189492
93Malaria_Homo sapiens_hsa051440.70807808
94Folate biosynthesis_Homo sapiens_hsa007900.69591841
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.69577651
96Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69194492
97Bile secretion_Homo sapiens_hsa049760.69156059
98Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68540754
99ECM-receptor interaction_Homo sapiens_hsa045120.68013719
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66558421
101Measles_Homo sapiens_hsa051620.65916477
102Intestinal immune network for IgA production_Homo sapiens_hsa046720.65774490
103mRNA surveillance pathway_Homo sapiens_hsa030150.65023488
104Phagosome_Homo sapiens_hsa041450.64222709
105Butanoate metabolism_Homo sapiens_hsa006500.64145944
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62586700
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62002116
108Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60165180
109Galactose metabolism_Homo sapiens_hsa000520.58622507
110Vitamin B6 metabolism_Homo sapiens_hsa007500.58181910
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58151188
112Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57941607
113Pyruvate metabolism_Homo sapiens_hsa006200.57702702
114Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57506073
115Chemokine signaling pathway_Homo sapiens_hsa040620.57121928
116Basal cell carcinoma_Homo sapiens_hsa052170.56990865
117Influenza A_Homo sapiens_hsa051640.56977599
118Thyroid hormone synthesis_Homo sapiens_hsa049180.56862820
119Purine metabolism_Homo sapiens_hsa002300.55317988
120Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54474170
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54045092
122Tuberculosis_Homo sapiens_hsa051520.53777649
123ABC transporters_Homo sapiens_hsa020100.53442849
124Prion diseases_Homo sapiens_hsa050200.52637257
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52375195
126Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51777921
127Pentose phosphate pathway_Homo sapiens_hsa000300.51272910
128Phototransduction_Homo sapiens_hsa047440.48942909
129Propanoate metabolism_Homo sapiens_hsa006400.48743371
130Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48671774
131Proteoglycans in cancer_Homo sapiens_hsa052050.48623554
132Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48043252
133Chemical carcinogenesis_Homo sapiens_hsa052040.47911763
134Hedgehog signaling pathway_Homo sapiens_hsa043400.47542409
135HIF-1 signaling pathway_Homo sapiens_hsa040660.47238983
136Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47182944
137Asthma_Homo sapiens_hsa053100.46468611
138Leishmaniasis_Homo sapiens_hsa051400.46119912
139MAPK signaling pathway_Homo sapiens_hsa040100.44112006
140TNF signaling pathway_Homo sapiens_hsa046680.43437395
141Long-term potentiation_Homo sapiens_hsa047200.42777798
142Pancreatic secretion_Homo sapiens_hsa049720.42736326
143TGF-beta signaling pathway_Homo sapiens_hsa043500.42127070
144Adherens junction_Homo sapiens_hsa045200.41423912
145Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.41070987
146Oxidative phosphorylation_Homo sapiens_hsa001900.40655543
147Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40162293
148Gastric acid secretion_Homo sapiens_hsa049710.39702112
149Salmonella infection_Homo sapiens_hsa051320.39211908
150NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38791231
151GnRH signaling pathway_Homo sapiens_hsa049120.37816275
152Ras signaling pathway_Homo sapiens_hsa040140.34758424
153Osteoclast differentiation_Homo sapiens_hsa043800.34740094
154Biosynthesis of amino acids_Homo sapiens_hsa012300.34367195
155Inositol phosphate metabolism_Homo sapiens_hsa005620.34046461
156Alcoholism_Homo sapiens_hsa050340.31053587
157Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27274040
158ErbB signaling pathway_Homo sapiens_hsa040120.26166721
159NF-kappa B signaling pathway_Homo sapiens_hsa040640.26068617
160Alzheimers disease_Homo sapiens_hsa050100.25595399

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