IL1RAPL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. It is most closely related to interleukin 1 receptor accessory protein-like 2 (IL1RAPL2). This gene and IL1RAPL2 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation. Deletions and mutations in this gene were found in patients with mental retardation. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* presynaptic membrane organization (GO:0097090)9.27916967
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.41049529
3* presynaptic membrane assembly (GO:0097105)6.34565767
4ionotropic glutamate receptor signaling pathway (GO:0035235)5.82347553
5negative regulation of synaptic transmission, GABAergic (GO:0032229)5.57838077
6neuron cell-cell adhesion (GO:0007158)5.54659365
7positive regulation of synapse assembly (GO:0051965)5.24495848
8vocalization behavior (GO:0071625)5.19849886
9synaptic transmission, glutamatergic (GO:0035249)5.17472843
10glutamate receptor signaling pathway (GO:0007215)5.09649220
11neuron-neuron synaptic transmission (GO:0007270)4.79621667
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.78227321
13regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.75453320
14negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.62511332
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.62070112
16gamma-aminobutyric acid signaling pathway (GO:0007214)4.58735321
17glutamate secretion (GO:0014047)4.58612542
18synaptic vesicle exocytosis (GO:0016079)4.32467805
19neuronal action potential propagation (GO:0019227)4.31510071
20protein localization to synapse (GO:0035418)4.30004089
21neurotransmitter-gated ion channel clustering (GO:0072578)4.28112107
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.23548328
23limb bud formation (GO:0060174)4.21013395
24neuron recognition (GO:0008038)4.20535504
25regulation of glutamate receptor signaling pathway (GO:1900449)4.17398344
26otic vesicle formation (GO:0030916)4.12903646
27regulation of long-term neuronal synaptic plasticity (GO:0048169)4.02618088
28regulation of excitatory postsynaptic membrane potential (GO:0060079)4.00712976
29regulation of synaptic vesicle exocytosis (GO:2000300)3.96634018
30regulation of synapse assembly (GO:0051963)3.93637795
31postsynaptic membrane organization (GO:0001941)3.89997594
32cerebellar granule cell differentiation (GO:0021707)3.89364103
33regulation of postsynaptic membrane potential (GO:0060078)3.83049049
34branching involved in labyrinthine layer morphogenesis (GO:0060670)3.79941269
35pyrimidine nucleobase catabolic process (GO:0006208)3.72609169
36positive regulation of cardiac muscle cell differentiation (GO:2000727)3.72049839
37transmission of nerve impulse (GO:0019226)3.70654144
38lateral sprouting from an epithelium (GO:0060601)3.68397348
39cell proliferation in forebrain (GO:0021846)3.68181010
40locomotory exploration behavior (GO:0035641)3.67295568
41regulation of synaptic transmission, glutamatergic (GO:0051966)3.57842575
42G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.57243843
43sulfation (GO:0051923)3.55849288
44positive regulation of mitochondrial fission (GO:0090141)3.52246962
45behavioral response to nicotine (GO:0035095)3.50904084
46behavioral defense response (GO:0002209)3.50779812
47behavioral fear response (GO:0001662)3.50779812
48gamma-aminobutyric acid transport (GO:0015812)3.50533496
49regulation of neuronal synaptic plasticity (GO:0048168)3.50166237
50membrane hyperpolarization (GO:0060081)3.49443743
51regulation of synaptic vesicle transport (GO:1902803)3.47499762
52histone H3-K36 demethylation (GO:0070544)3.45759403
53startle response (GO:0001964)3.45707143
54prostate gland growth (GO:0060736)3.40982524
55somite development (GO:0061053)3.40800597
56positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.34462224
57response to histamine (GO:0034776)3.33730527
58axonal fasciculation (GO:0007413)3.32562207
59fear response (GO:0042596)3.32328789
60regulation of synapse organization (GO:0050807)3.31756322
61long-term synaptic potentiation (GO:0060291)3.31369622
62positive regulation of membrane potential (GO:0045838)3.29183235
63synaptic vesicle docking involved in exocytosis (GO:0016081)3.27098025
64mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.26693245
65mitochondrial respiratory chain complex I assembly (GO:0032981)3.26693245
66NADH dehydrogenase complex assembly (GO:0010257)3.26693245
67neurotransmitter secretion (GO:0007269)3.25212222
68mannosylation (GO:0097502)3.19469854
69regulation of synaptic transmission, GABAergic (GO:0032228)3.16875636
70membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.16255120
71negative regulation of synaptic transmission (GO:0050805)3.12937362
72exploration behavior (GO:0035640)3.10739669
73positive regulation of synapse maturation (GO:0090129)3.10032219
74regulation of synaptic plasticity (GO:0048167)3.09698857
75histone H3-K9 demethylation (GO:0033169)3.08622243
76negative regulation of neurotransmitter transport (GO:0051589)3.08506433
77neuronal ion channel clustering (GO:0045161)3.07699159
78membrane depolarization (GO:0051899)3.07079155
79L-amino acid import (GO:0043092)3.04701231
80long-term memory (GO:0007616)3.03095871
81regulation of telomere maintenance via telomerase (GO:0032210)3.02610954
82behavioral response to cocaine (GO:0048148)3.00958924
83dendrite development (GO:0016358)3.00000266
84dendritic spine morphogenesis (GO:0060997)2.99489012
85long-chain fatty acid biosynthetic process (GO:0042759)2.94575954
86positive regulation of synaptic transmission, GABAergic (GO:0032230)2.93705748
87regulation of dendritic spine morphogenesis (GO:0061001)2.93489776
88regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.93424502
89protein polyglutamylation (GO:0018095)2.93061455
90nonmotile primary cilium assembly (GO:0035058)2.92357485
91regulation of neurotransmitter secretion (GO:0046928)2.92324155
92synaptic vesicle endocytosis (GO:0048488)2.91341164
93negative regulation of systemic arterial blood pressure (GO:0003085)2.90936333
94layer formation in cerebral cortex (GO:0021819)2.90071629
95negative regulation of astrocyte differentiation (GO:0048712)2.89455795
96regulation of glutamate secretion (GO:0014048)2.89086931
97positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.88536376
98mechanosensory behavior (GO:0007638)2.87758883
99central nervous system projection neuron axonogenesis (GO:0021952)2.87743975
100regulation of synapse structural plasticity (GO:0051823)2.87684393
101neurotransmitter transport (GO:0006836)2.86699474
102amino acid import (GO:0043090)2.86245570
103regulation of synapse maturation (GO:0090128)2.86046333
104female mating behavior (GO:0060180)2.85266783
105* membrane assembly (GO:0071709)2.85142412
106cGMP metabolic process (GO:0046068)2.84769563
107serotonin metabolic process (GO:0042428)2.84286716
108regulation of collateral sprouting (GO:0048670)2.84194780
109synaptic vesicle maturation (GO:0016188)2.82422797
110regulation of dendritic spine development (GO:0060998)2.81333679
111spinal cord development (GO:0021510)2.81320898
112nucleobase catabolic process (GO:0046113)2.79357384
113appendage development (GO:0048736)2.78544282
114limb development (GO:0060173)2.78544282
115learning (GO:0007612)2.78279720
116positive regulation of synaptic transmission (GO:0050806)2.76130417
117synaptic transmission (GO:0007268)2.75588720
118protein complex biogenesis (GO:0070271)2.75134039
119detection of calcium ion (GO:0005513)2.75017369
120central nervous system myelination (GO:0022010)2.74773876
121axon ensheathment in central nervous system (GO:0032291)2.74773876
122replication fork processing (GO:0031297)2.74484653
123synapse assembly (GO:0007416)2.74024934
124negative regulation of neurotransmitter secretion (GO:0046929)2.73293910
125positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.72914791
126regulation of glomerulus development (GO:0090192)2.72289763
127cochlea development (GO:0090102)2.70705829
128auditory behavior (GO:0031223)2.69243893
129positive regulation of neurotransmitter secretion (GO:0001956)2.67571584
130retinal ganglion cell axon guidance (GO:0031290)2.66017205
131positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.65391281
132negative regulation of transcription regulatory region DNA binding (GO:2000678)2.65089298
133regulation of cell proliferation involved in kidney development (GO:1901722)2.63782277
134regulation of DNA endoreduplication (GO:0032875)2.61809468
135retinal cone cell development (GO:0046549)2.53171630
136positive regulation of potassium ion transmembrane transport (GO:1901381)2.51164338
137primary amino compound metabolic process (GO:1901160)2.50198671
138organ growth (GO:0035265)2.49161631
139synapsis (GO:0007129)2.49119225
140dendrite morphogenesis (GO:0048813)2.46659293
141mitochondrial respiratory chain complex assembly (GO:0033108)2.46618641
142spindle assembly involved in mitosis (GO:0090307)2.46073131
143glycosphingolipid biosynthetic process (GO:0006688)2.43292122
144cilium morphogenesis (GO:0060271)2.41705309
145thalamus development (GO:0021794)2.39272563
146positive regulation of oligodendrocyte differentiation (GO:0048714)2.39158309
147substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.36457555
148substrate-independent telencephalic tangential migration (GO:0021826)2.36457555
149neuronal action potential (GO:0019228)2.35823846
150photoreceptor cell development (GO:0042461)2.35289325
151centriole replication (GO:0007099)2.35217373
152regulation of mitochondrial fission (GO:0090140)2.34377841
153adult walking behavior (GO:0007628)2.33557845
154DNA integration (GO:0015074)2.33540143
155adaptation of signaling pathway (GO:0023058)2.32696615
156C4-dicarboxylate transport (GO:0015740)2.31997619
157regulation of timing of cell differentiation (GO:0048505)2.31916433
158negative regulation of cytosolic calcium ion concentration (GO:0051481)2.31322346
159forebrain neuron development (GO:0021884)2.30644231
160regulation of action potential (GO:0098900)2.30435180
161cerebral cortex radially oriented cell migration (GO:0021799)2.30244480
1623-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.28892579
163purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.28892579
164regulation of phospholipid biosynthetic process (GO:0071071)2.28840700
165anterior/posterior axis specification, embryo (GO:0008595)2.27580510
166positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.27439729
167regulation of mesoderm development (GO:2000380)2.25983088
168eye photoreceptor cell development (GO:0042462)2.24519691
169lung morphogenesis (GO:0060425)2.24183940
170maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.22776115
171peroxisome fission (GO:0016559)2.22188285
172organ induction (GO:0001759)2.21663825
173positive regulation of dendritic spine morphogenesis (GO:0061003)2.21440486
174epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.21365377
175anterograde axon cargo transport (GO:0008089)2.20835359
176epithelial cilium movement (GO:0003351)2.20779463

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.27990758
2GBX2_23144817_ChIP-Seq_PC3_Human4.79923278
3TAF15_26573619_Chip-Seq_HEK293_Human2.94215082
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.91965621
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.89222267
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.88233196
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.75679828
8ZNF274_21170338_ChIP-Seq_K562_Hela2.55370315
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.49251507
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45205697
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.44011488
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.42498637
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.42498637
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.41692600
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.41619143
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.41593813
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.39286072
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.39206096
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37771948
20REST_21632747_ChIP-Seq_MESCs_Mouse2.13572911
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.11644557
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.09488053
23CTBP1_25329375_ChIP-Seq_LNCAP_Human2.07583494
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.04139057
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.00454839
26* P300_19829295_ChIP-Seq_ESCs_Human1.93305694
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.92890945
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.91688216
29* SMAD4_21799915_ChIP-Seq_A2780_Human1.89590275
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.86167725
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.83732996
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.83620584
33VDR_22108803_ChIP-Seq_LS180_Human1.81430964
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.80234307
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.79948087
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78921743
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.77901671
38* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75813871
39AR_21572438_ChIP-Seq_LNCaP_Human1.74414019
40* FUS_26573619_Chip-Seq_HEK293_Human1.74199766
41DROSHA_22980978_ChIP-Seq_HELA_Human1.71030879
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.70199804
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.69411839
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.67346859
45SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62654063
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.61409212
47REST_18959480_ChIP-ChIP_MESCs_Mouse1.60393944
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.59100317
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.58910583
50RARB_27405468_Chip-Seq_BRAIN_Mouse1.58539032
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.57433253
52BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.54330678
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51852382
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.51684011
55HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.50136139
56RNF2_27304074_Chip-Seq_NSC_Mouse1.49446285
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48360492
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46049021
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45344965
60* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.42814490
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40102903
62ER_23166858_ChIP-Seq_MCF-7_Human1.39772182
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38276370
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34999783
65VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.34718355
66AR_25329375_ChIP-Seq_VCAP_Human1.33201068
67* STAT3_23295773_ChIP-Seq_U87_Human1.30549929
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29061101
69EST1_17652178_ChIP-ChIP_JURKAT_Human1.28753368
70* ARNT_22903824_ChIP-Seq_MCF-7_Human1.28469856
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28311565
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28311565
73ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28121549
74NANOG_18555785_Chip-Seq_ESCs_Mouse1.28011178
75* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26757574
76* TCF4_23295773_ChIP-Seq_U87_Human1.25671785
77IGF1R_20145208_ChIP-Seq_DFB_Human1.24882557
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24435616
79IRF1_19129219_ChIP-ChIP_H3396_Human1.24165113
80GABP_17652178_ChIP-ChIP_JURKAT_Human1.23445243
81SOX2_21211035_ChIP-Seq_LN229_Gbm1.23316776
82KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.22764534
83MYC_18940864_ChIP-ChIP_HL60_Human1.21829901
84CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19515570
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.18004986
86ELK1_19687146_ChIP-ChIP_HELA_Human1.16173613
87TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.15330601
88AHR_22903824_ChIP-Seq_MCF-7_Human1.15300020
89TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14777724
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14683635
91EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14441564
92TCF4_22108803_ChIP-Seq_LS180_Human1.14196524
93CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13968345
94KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13202078
95RUNX2_22187159_ChIP-Seq_PCA_Human1.13041122
96E2F1_18555785_Chip-Seq_ESCs_Mouse1.11673994
97ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11608701
98PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06465553
99RING1B_27294783_Chip-Seq_ESCs_Mouse1.06246863
100LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05928733
101TP53_16413492_ChIP-PET_HCT116_Human1.05875403
102TAL1_26923725_Chip-Seq_HPCs_Mouse1.05841072
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05458901
104BCAT_22108803_ChIP-Seq_LS180_Human1.05415508
105CMYC_18555785_Chip-Seq_ESCs_Mouse1.04807875
106TP53_18474530_ChIP-ChIP_U2OS_Human1.04711001
107SMAD4_21741376_ChIP-Seq_EPCs_Human1.04688451
108FLI1_27457419_Chip-Seq_LIVER_Mouse1.04613594
109P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04224049
110P53_22387025_ChIP-Seq_ESCs_Mouse1.03974886
111SOX9_26525672_Chip-Seq_HEART_Mouse1.02713259
112EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02658935
113YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02565225
114NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02114139
115NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01773708
116KDM2B_26808549_Chip-Seq_REH_Human1.01413477
117E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.01020324
118EWS_26573619_Chip-Seq_HEK293_Human0.99607524
119JUN_21703547_ChIP-Seq_K562_Human0.98977126
120MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98639744
121MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97659099
122* AR_19668381_ChIP-Seq_PC3_Human0.97284549
123SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95975457
124EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.95873984
125CBP_20019798_ChIP-Seq_JUKART_Human0.95321004

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.02278675
2MP0004859_abnormal_synaptic_plasticity4.92014269
3* MP0003635_abnormal_synaptic_transmissio3.63817606
4MP0001188_hyperpigmentation3.52401646
5MP0009745_abnormal_behavioral_response3.51725246
6MP0005171_absent_coat_pigmentation3.25322918
7MP0004270_analgesia3.20974586
8MP0002064_seizures3.14154226
9MP0009046_muscle_twitch3.05240840
10MP0002063_abnormal_learning/memory/cond2.99722760
11MP0002572_abnormal_emotion/affect_behav2.83285282
12MP0001968_abnormal_touch/_nociception2.73974933
13MP0002272_abnormal_nervous_system2.62887370
14MP0001486_abnormal_startle_reflex2.58932713
15MP0001440_abnormal_grooming_behavior2.39679788
16MP0002736_abnormal_nociception_after2.37523635
17MP0002735_abnormal_chemical_nociception2.36362591
18MP0005423_abnormal_somatic_nervous2.23407384
19MP0002734_abnormal_mechanical_nocicepti2.15411392
20MP0009379_abnormal_foot_pigmentation2.15000272
21MP0000566_synostosis2.14585541
22MP0002067_abnormal_sensory_capabilities2.08909072
23MP0001529_abnormal_vocalization2.07409664
24MP0000778_abnormal_nervous_system2.01944747
25MP0001501_abnormal_sleep_pattern2.00236216
26MP0000049_abnormal_middle_ear1.96948199
27MP0002733_abnormal_thermal_nociception1.88552618
28MP0003119_abnormal_digestive_system1.78260338
29MP0002557_abnormal_social/conspecific_i1.73729456
30MP0001970_abnormal_pain_threshold1.73149489
31MP0003303_peritoneal_inflammation1.71474733
32MP0010030_abnormal_orbit_morphology1.70569614
33MP0008877_abnormal_DNA_methylation1.69809111
34MP0002822_catalepsy1.69500181
35MP0008789_abnormal_olfactory_epithelium1.68921327
36MP0008569_lethality_at_weaning1.67463518
37MP0003937_abnormal_limbs/digits/tail_de1.65523403
38MP0002184_abnormal_innervation1.65101990
39MP0005386_behavior/neurological_phenoty1.64007999
40MP0004924_abnormal_behavior1.64007999
41MP0000516_abnormal_urinary_system1.63347869
42MP0005367_renal/urinary_system_phenotyp1.63347869
43MP0005670_abnormal_white_adipose1.62470707
44MP0006292_abnormal_olfactory_placode1.59414969
45MP0002653_abnormal_ependyma_morphology1.58386031
46MP0003890_abnormal_embryonic-extraembry1.55511138
47MP0005409_darkened_coat_color1.55053512
48MP0006276_abnormal_autonomic_nervous1.54869265
49MP0004742_abnormal_vestibular_system1.53423910
50MP0001905_abnormal_dopamine_level1.52470135
51MP0004142_abnormal_muscle_tone1.50276252
52MP0005646_abnormal_pituitary_gland1.49217708
53MP0002234_abnormal_pharynx_morphology1.43343958
54MP0000537_abnormal_urethra_morphology1.41942041
55MP0005248_abnormal_Harderian_gland1.40613277
56MP0002282_abnormal_trachea_morphology1.39397510
57MP0003718_maternal_effect1.33933963
58MP0001299_abnormal_eye_distance/1.33869646
59MP0002066_abnormal_motor_capabilities/c1.33602204
60MP0001293_anophthalmia1.30940453
61MP0000955_abnormal_spinal_cord1.30913573
62MP0004811_abnormal_neuron_physiology1.30509848
63MP0009053_abnormal_anal_canal1.29166485
64MP0001984_abnormal_olfaction1.28010865
65MP0002882_abnormal_neuron_morphology1.27497527
66MP0003329_amyloid_beta_deposits1.27274492
67MP0000015_abnormal_ear_pigmentation1.26793834
68MP0003787_abnormal_imprinting1.24503541
69MP0005253_abnormal_eye_physiology1.24014934
70MP0000383_abnormal_hair_follicle1.22951449
71MP0008995_early_reproductive_senescence1.19804660
72MP0003121_genomic_imprinting1.19611204
73MP0006072_abnormal_retinal_apoptosis1.15118598
74MP0003633_abnormal_nervous_system1.14227554
75MP0000920_abnormal_myelination1.13768518
76MP0002938_white_spotting1.12752433
77MP0003879_abnormal_hair_cell1.12572836
78MP0001502_abnormal_circadian_rhythm1.12311660
79MP0002160_abnormal_reproductive_system1.11867641
80MP0008872_abnormal_physiological_respon1.09824350
81MP0004133_heterotaxia1.09790689
82MP0003315_abnormal_perineum_morphology1.07092159
83MP0003122_maternal_imprinting1.06578141
84MP0004147_increased_porphyrin_level1.06281494
85MP0004134_abnormal_chest_morphology1.04492814
86MP0004885_abnormal_endolymph1.04101100
87MP0009250_abnormal_appendicular_skeleto1.03974843
88MP0001963_abnormal_hearing_physiology1.03166633
89MP0005645_abnormal_hypothalamus_physiol1.02831893
90MP0003868_abnormal_feces_composition1.02159884
91MP0000462_abnormal_digestive_system1.01055702
92* MP0002152_abnormal_brain_morphology1.00656633
93MP0000647_abnormal_sebaceous_gland0.98508084
94MP0005195_abnormal_posterior_eye0.97532178
95MP0003631_nervous_system_phenotype0.97461589
96MP0005551_abnormal_eye_electrophysiolog0.95423069
97MP0004130_abnormal_muscle_cell0.95194963
98MP0003861_abnormal_nervous_system0.93563683
99MP0003136_yellow_coat_color0.90857946
100MP0001485_abnormal_pinna_reflex0.90676668
101MP0002229_neurodegeneration0.90090504
102MP0003755_abnormal_palate_morphology0.89688285
103MP0002233_abnormal_nose_morphology0.89185869
104MP0009780_abnormal_chondrocyte_physiolo0.88113551
105MP0002069_abnormal_eating/drinking_beha0.87651774
106MP0000631_abnormal_neuroendocrine_gland0.87040002
107MP0000534_abnormal_ureter_morphology0.85864189
108MP0001664_abnormal_digestion0.85595902
109MP0002752_abnormal_somatic_nervous0.85270182
110MP0003385_abnormal_body_wall0.83412566
111MP0002837_dystrophic_cardiac_calcinosis0.81349872
112MP0000427_abnormal_hair_cycle0.80314664
113MP0000026_abnormal_inner_ear0.79960340
114MP0003942_abnormal_urinary_system0.79800599
115MP0000013_abnormal_adipose_tissue0.79137719
116MP0004145_abnormal_muscle_electrophysio0.78478268
117MP0003938_abnormal_ear_development0.77931743
118MP0005187_abnormal_penis_morphology0.77653025
119MP0004858_abnormal_nervous_system0.75885288
120MP0002876_abnormal_thyroid_physiology0.75018416
121MP0003634_abnormal_glial_cell0.74085561
122MP0002102_abnormal_ear_morphology0.73747413
123MP0002638_abnormal_pupillary_reflex0.73727217
124MP0000372_irregular_coat_pigmentation0.72468131
125MP0005535_abnormal_body_temperature0.72326796
126MP0003690_abnormal_glial_cell0.72009135
127MP0008874_decreased_physiological_sensi0.71588576
128MP0005499_abnormal_olfactory_system0.71456272
129MP0005394_taste/olfaction_phenotype0.71456272
130MP0003632_abnormal_nervous_system0.69677810
131MP0002751_abnormal_autonomic_nervous0.69536779
132MP0001177_atelectasis0.68239492
133MP0010386_abnormal_urinary_bladder0.65457164
134MP0004085_abnormal_heartbeat0.65257140
135MP0005595_abnormal_vascular_smooth0.62193474
136MP0000751_myopathy0.59851763
137MP0002082_postnatal_lethality0.56242775
138MP0010770_preweaning_lethality0.56242775

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.67956945
2Retinal dysplasia (HP:0007973)5.40378284
3Atonic seizures (HP:0010819)4.77961257
4Focal seizures (HP:0007359)4.75814527
5Epileptic encephalopathy (HP:0200134)4.72042919
6Retinal atrophy (HP:0001105)4.71035737
7Type II lissencephaly (HP:0007260)4.68300012
8Absent speech (HP:0001344)4.46448323
9Febrile seizures (HP:0002373)4.33382101
10Inability to walk (HP:0002540)4.21358969
11Hyperventilation (HP:0002883)4.10234915
12Cerebellar dysplasia (HP:0007033)4.07423086
13Stenosis of the external auditory canal (HP:0000402)3.93690570
14Scanning speech (HP:0002168)3.76703008
15Dialeptic seizures (HP:0011146)3.67253841
16Buphthalmos (HP:0000557)3.65453780
17Anterior segment dysgenesis (HP:0007700)3.43524975
18Myokymia (HP:0002411)3.40433808
19Absence seizures (HP:0002121)3.39171654
20Hepatoblastoma (HP:0002884)3.33768297
21Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.26570325
22Short 1st metacarpal (HP:0010034)3.26570325
23True hermaphroditism (HP:0010459)3.22481846
24Pancreatic cysts (HP:0001737)3.20686527
25Broad-based gait (HP:0002136)3.10644350
26Pendular nystagmus (HP:0012043)3.10009832
27Occipital encephalocele (HP:0002085)3.07927999
28Neoplasm of the adrenal cortex (HP:0100641)3.05265498
29Progressive cerebellar ataxia (HP:0002073)2.99025075
30Pancreatic fibrosis (HP:0100732)2.98205421
31Abnormality of midbrain morphology (HP:0002418)2.95467113
32Molar tooth sign on MRI (HP:0002419)2.95467113
33Generalized tonic-clonic seizures (HP:0002069)2.87102485
34Gaze-evoked nystagmus (HP:0000640)2.84687322
35Spinal rigidity (HP:0003306)2.84171449
36Abnormality of the 1st metacarpal (HP:0010009)2.82624863
37Sensory axonal neuropathy (HP:0003390)2.82204374
38Ankle clonus (HP:0011448)2.82117197
39Degeneration of the lateral corticospinal tracts (HP:0002314)2.73448603
40Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.73448603
41Aplasia/Hypoplasia of the hallux (HP:0008362)2.68216276
42Visual hallucinations (HP:0002367)2.66202919
43Stomach cancer (HP:0012126)2.65864009
44Abnormal eating behavior (HP:0100738)2.64513609
45Slender build (HP:0001533)2.63135572
46Abnormality of the middle phalanges of the toes (HP:0010183)2.62679829
47Short phalanx of the thumb (HP:0009660)2.62133241
48Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.57274009
49Abnormality of the corticospinal tract (HP:0002492)2.55236009
50Short hallux (HP:0010109)2.54115016
51Drooling (HP:0002307)2.49833608
52Excessive salivation (HP:0003781)2.49833608
53Optic nerve hypoplasia (HP:0000609)2.49177819
54Gait imbalance (HP:0002141)2.43507415
55Epileptiform EEG discharges (HP:0011182)2.42516967
56Hypoplasia of the brainstem (HP:0002365)2.42246965
57Aplasia/Hypoplasia of the brainstem (HP:0007362)2.42246965
58Neoplasm of the oral cavity (HP:0100649)2.39345235
59Spastic gait (HP:0002064)2.38948571
60Nephronophthisis (HP:0000090)2.38161513
61Sclerocornea (HP:0000647)2.36518125
62Impaired vibration sensation in the lower limbs (HP:0002166)2.34114885
63Truncal ataxia (HP:0002078)2.33313314
64Fetal akinesia sequence (HP:0001989)2.32703084
65Progressive inability to walk (HP:0002505)2.31911423
66Humeroradial synostosis (HP:0003041)2.27151381
67Synostosis involving the elbow (HP:0003938)2.27151381
68Abnormal hair whorl (HP:0010721)2.27006195
69Thickened helices (HP:0000391)2.26918844
70Abnormality of the proximal phalanges of the hand (HP:0009834)2.26449287
71Lissencephaly (HP:0001339)2.25016156
72Ectopic kidney (HP:0000086)2.24710316
73Congenital glaucoma (HP:0001087)2.23462833
74Urinary bladder sphincter dysfunction (HP:0002839)2.23404285
75Preaxial hand polydactyly (HP:0001177)2.23212196
76Renal hypoplasia (HP:0000089)2.23011345
77Nemaline bodies (HP:0003798)2.22371591
78EEG with generalized epileptiform discharges (HP:0011198)2.22229210
79Papillary thyroid carcinoma (HP:0002895)2.21948895
80Poor eye contact (HP:0000817)2.19229082
81Medial flaring of the eyebrow (HP:0010747)2.18592666
82Aplasia/Hypoplasia of the tongue (HP:0010295)2.18140344
83Acute necrotizing encephalopathy (HP:0006965)2.18099048
84Abnormality of the labia minora (HP:0012880)2.17512859
85Chronic hepatic failure (HP:0100626)2.17133683
86Congenital primary aphakia (HP:0007707)2.15788319
87Dysmetria (HP:0001310)2.14885767
88Pheochromocytoma (HP:0002666)2.14367417
89Abolished electroretinogram (ERG) (HP:0000550)2.13940485
90Meningocele (HP:0002435)2.13651517
91Intestinal atresia (HP:0011100)2.12162218
92Protruding tongue (HP:0010808)2.10984504
93Increased corneal curvature (HP:0100692)2.10764634
94Keratoconus (HP:0000563)2.10764634
95Severe muscular hypotonia (HP:0006829)2.10758962
96Anencephaly (HP:0002323)2.09416812
97Renal dysplasia (HP:0000110)2.07956417
98Aplasia/Hypoplasia of the tibia (HP:0005772)2.07135739
99Chromosomal breakage induced by crosslinking agents (HP:0003221)2.06934219
100Dysdiadochokinesis (HP:0002075)2.06786565
101Absent/shortened dynein arms (HP:0200106)2.06620490
102Dynein arm defect of respiratory motile cilia (HP:0012255)2.06620490
103Carpal bone hypoplasia (HP:0001498)2.05808119
104Hypsarrhythmia (HP:0002521)2.05415151
105Amblyopia (HP:0000646)2.04662164
106Absent thumb (HP:0009777)2.04075158
107Congenital, generalized hypertrichosis (HP:0004540)2.03092628
108Fused cervical vertebrae (HP:0002949)2.02013669
109Bradykinesia (HP:0002067)2.01977494
110Termporal pattern (HP:0011008)2.01974494
111Insidious onset (HP:0003587)2.01974494
112Amyotrophic lateral sclerosis (HP:0007354)2.01706224
113Hemiparesis (HP:0001269)2.01307282
114Cutaneous finger syndactyly (HP:0010554)2.00897723
115Synostosis of carpal bones (HP:0005048)1.99658454
116Aplasia/Hypoplasia of the uvula (HP:0010293)1.99648558
117Blue irides (HP:0000635)1.99093914
118Vaginal atresia (HP:0000148)1.98918544
119Progressive macrocephaly (HP:0004481)1.98669574
120Cystic liver disease (HP:0006706)1.98244079
121Nephrogenic diabetes insipidus (HP:0009806)1.98178896
122Septo-optic dysplasia (HP:0100842)1.97986476
123Difficulty climbing stairs (HP:0003551)1.96851830
124Genital tract atresia (HP:0001827)1.96782230
125Akinesia (HP:0002304)1.96708164
126Meckel diverticulum (HP:0002245)1.96472721
127Abnormality of the ileum (HP:0001549)1.96424951
128Non-midline cleft lip (HP:0100335)1.96148963
129Epidermoid cyst (HP:0200040)1.95331550
130Short tibia (HP:0005736)1.94783317
131Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.93344367
132Neurofibrillary tangles (HP:0002185)1.92522916
133Abnormality of DNA repair (HP:0003254)1.92261319
134Abnormal social behavior (HP:0012433)1.92008497
135Impaired social interactions (HP:0000735)1.92008497
136Polyphagia (HP:0002591)1.91610883
137Abnormality of the renal collecting system (HP:0004742)1.90975300
138Neuroendocrine neoplasm (HP:0100634)1.90859706
139Chromsome breakage (HP:0040012)1.90454378
140Genetic anticipation (HP:0003743)1.89683204
141Diplopia (HP:0000651)1.89146486
142Abnormality of binocular vision (HP:0011514)1.89146486
143Ragged-red muscle fibers (HP:0003200)1.88384969
144Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.88160901
145Short 4th metacarpal (HP:0010044)1.88160901
146Lower limb muscle weakness (HP:0007340)1.87985823
147Chorioretinal atrophy (HP:0000533)1.87072649
148Abnormal mitochondria in muscle tissue (HP:0008316)1.86580189
149Absent radius (HP:0003974)1.85616675
150Abnormality of the renal medulla (HP:0100957)1.85516012
151Congenital sensorineural hearing impairment (HP:0008527)1.84615838
152Esotropia (HP:0000565)1.83986089
153Mitochondrial inheritance (HP:0001427)1.83915830
154Abnormality of glycolysis (HP:0004366)1.83616623
155Increased serum pyruvate (HP:0003542)1.83616623
156Abnormality of salivation (HP:0100755)1.83101146
157Anxiety (HP:0000739)1.82778161
158Astrocytoma (HP:0009592)1.82170572
159Abnormality of the astrocytes (HP:0100707)1.82170572
160Absent forearm bone (HP:0003953)1.81742399
161Aplasia involving forearm bones (HP:0009822)1.81742399
162Postaxial hand polydactyly (HP:0001162)1.81602735
163Volvulus (HP:0002580)1.79856912
164Adrenal hypoplasia (HP:0000835)1.79791833
165Gastrointestinal atresia (HP:0002589)1.79450589
166Male pseudohermaphroditism (HP:0000037)1.78411801
167Aplasia/Hypoplasia of the sternum (HP:0006714)1.78010275
168Abnormality of the phalanges of the 2nd finger (HP:0009541)1.77807525
169Symphalangism affecting the phalanges of the hand (HP:0009773)1.77317283
170Abnormality of the carotid arteries (HP:0005344)1.74302622
171Preaxial foot polydactyly (HP:0001841)1.74217245
172Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.74057549
173Postaxial foot polydactyly (HP:0001830)1.74034982
174Absent septum pellucidum (HP:0001331)1.73545706
175Megalencephaly (HP:0001355)1.73231518

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.06506133
2EPHA43.54159614
3PNCK3.51021743
4NTRK33.50782113
5TNIK3.01397168
6MARK12.81822659
7MAP2K72.56255399
8MAP3K42.51118402
9FES2.48809887
10TRIM282.36640819
11AKT32.03562521
12GRK11.98999497
13NTRK21.95750678
14OXSR11.83853554
15CDK191.82940853
16PRPF4B1.79852302
17CSNK1A1L1.75357284
18MAPK131.73983589
19FRK1.71539528
20CSNK1G31.69176197
21MAP3K91.67825680
22MINK11.67353684
23NUAK11.66887267
24MAP3K121.66479500
25CSNK1G21.65809109
26PLK21.62950454
27DAPK21.56340305
28CDC71.53254025
29CAMK1G1.49748372
30ERBB31.47234638
31KSR11.43961637
32RIPK41.41914784
33PAK61.41833202
34ARAF1.37340491
35MAP4K21.36438013
36DYRK21.34966947
37ZAK1.33064153
38MAP2K41.28577425
39PRKCG1.27208179
40SGK2231.26689095
41SGK4941.26689095
42BUB11.25201051
43EPHA31.23273373
44CSNK1G11.23031576
45ACVR1B1.22854140
46STK391.22349899
47SGK21.21835444
48VRK11.17593590
49DAPK11.15746516
50STK161.12809476
51CDK51.12370115
52CAMKK21.11080453
53CAMK2A1.07409881
54CAMK2B1.02121725
55CCNB11.01656863
56AURKA0.99567299
57VRK20.99216225
58BRAF0.99172014
59FER0.97793692
60UHMK10.96091567
61LIMK10.94646687
62SIK20.94479360
63CAMK2G0.94198254
64EPHB20.90400244
65CAMK10.87102422
66PRKCE0.87001074
67CDK90.84304224
68NTRK10.83558267
69KSR20.83026835
70PBK0.82233049
71CDK80.81709389
72GRK50.80971333
73PRKD30.80073722
74BMPR20.76821482
75FGR0.76351130
76PKN10.75261607
77ERBB40.74332831
78SGK30.73798892
79MKNK20.72525601
80TLK10.72330768
81TYRO30.71454771
82SIK30.71154148
83BCR0.70845563
84PLK40.68495424
85RAF10.68222594
86SGK10.68145385
87MARK20.66218817
88BCKDK0.66040108
89MUSK0.65773781
90NME10.65768589
91CAMK2D0.65740681
92WNK30.64308173
93PRKD20.62003111
94CSNK1D0.61282920
95DYRK1A0.60681507
96TGFBR10.60036338
97PLK30.59317569
98ADRBK20.58636394
99PLK10.58630823
100WNK10.58599304
101PAK30.58384330
102TAF10.57826870
103TNK20.57646910
104ADRBK10.57395961
105GRK70.56805477
106FGFR10.55171954
107CDK30.54730683
108CAMKK10.54630641
109PRKG10.54251055
110PTK2B0.54193657
111ROCK20.53222184
112WEE10.52929671
113SRPK10.51414192
114ATR0.49776104
115MET0.49744850
116STK110.49282462
117CDK180.49202911
118BRSK20.48798043
119PINK10.47889398
120MAPKAPK50.45669633
121PHKG20.45386923
122PHKG10.45386923
123CDK140.45355273
124NEK60.44823438
125CDK150.44696408
126PRKACA0.44681391
127MAP2K10.42691993
128CSNK1A10.40166317
129ATM0.39792009
130EIF2AK20.39767310
131IRAK20.38755776
132CDK11A0.37918086
133PRKCZ0.36871071
134PRKACB0.36765652
135MAPK120.34913674
136MAP3K10.34899888
137PRKCI0.34514837
138DYRK30.33822341
139BMPR1B0.33213971
140FGFR20.33056948
141MAPK70.32689019
142RPS6KA50.32107630
143CAMK40.31918563
144FYN0.31292351
145INSRR0.31208836
146WNK40.31042580

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.71615940
2Synaptic vesicle cycle_Homo sapiens_hsa047213.05892985
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.03393319
4Glutamatergic synapse_Homo sapiens_hsa047242.77257500
5Circadian entrainment_Homo sapiens_hsa047132.72529543
6GABAergic synapse_Homo sapiens_hsa047272.64511766
7Morphine addiction_Homo sapiens_hsa050322.53363716
8Collecting duct acid secretion_Homo sapiens_hsa049662.38536570
9Long-term potentiation_Homo sapiens_hsa047202.35202694
10Amphetamine addiction_Homo sapiens_hsa050312.35180838
11Long-term depression_Homo sapiens_hsa047302.22820448
12Sulfur metabolism_Homo sapiens_hsa009202.18743024
13Salivary secretion_Homo sapiens_hsa049702.15109767
14Serotonergic synapse_Homo sapiens_hsa047261.99543135
15Taste transduction_Homo sapiens_hsa047421.99114796
16Olfactory transduction_Homo sapiens_hsa047401.98948850
17Dopaminergic synapse_Homo sapiens_hsa047281.98316121
18Renin secretion_Homo sapiens_hsa049241.96130685
19Oxidative phosphorylation_Homo sapiens_hsa001901.90865939
20Homologous recombination_Homo sapiens_hsa034401.90629657
21Basal transcription factors_Homo sapiens_hsa030221.87686926
22Fanconi anemia pathway_Homo sapiens_hsa034601.73433266
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.70501668
24Cocaine addiction_Homo sapiens_hsa050301.64581436
25Insulin secretion_Homo sapiens_hsa049111.61918852
26Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.61222574
27RNA polymerase_Homo sapiens_hsa030201.58530310
28Cholinergic synapse_Homo sapiens_hsa047251.53237228
29Nitrogen metabolism_Homo sapiens_hsa009101.49650282
30Calcium signaling pathway_Homo sapiens_hsa040201.49022354
31Basal cell carcinoma_Homo sapiens_hsa052171.48922125
32Oxytocin signaling pathway_Homo sapiens_hsa049211.44775584
33Axon guidance_Homo sapiens_hsa043601.44376240
34Alzheimers disease_Homo sapiens_hsa050101.41195347
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.40925800
36Gastric acid secretion_Homo sapiens_hsa049711.39300149
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.34439755
38Protein export_Homo sapiens_hsa030601.33347641
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.32565994
40Gap junction_Homo sapiens_hsa045401.31081105
41Vibrio cholerae infection_Homo sapiens_hsa051101.30211672
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.27162287
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.26497483
44Cardiac muscle contraction_Homo sapiens_hsa042601.24082275
45Hedgehog signaling pathway_Homo sapiens_hsa043401.24035322
46Parkinsons disease_Homo sapiens_hsa050121.19807594
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18772879
48cAMP signaling pathway_Homo sapiens_hsa040241.17850191
49RNA degradation_Homo sapiens_hsa030181.15503470
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.13051939
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.09646085
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.06694737
53Phototransduction_Homo sapiens_hsa047441.02453621
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.01431104
55beta-Alanine metabolism_Homo sapiens_hsa004101.00683182
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.99652199
57Chemical carcinogenesis_Homo sapiens_hsa052040.99314391
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98061932
59Hippo signaling pathway_Homo sapiens_hsa043900.97482479
60Huntingtons disease_Homo sapiens_hsa050160.96603228
61GnRH signaling pathway_Homo sapiens_hsa049120.96011183
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.94717106
63Nucleotide excision repair_Homo sapiens_hsa034200.92514011
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92225980
65Proteasome_Homo sapiens_hsa030500.91374497
66ErbB signaling pathway_Homo sapiens_hsa040120.90498097
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88134260
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85648785
69Propanoate metabolism_Homo sapiens_hsa006400.85564554
70Estrogen signaling pathway_Homo sapiens_hsa049150.81948447
71Melanogenesis_Homo sapiens_hsa049160.77831097
72TGF-beta signaling pathway_Homo sapiens_hsa043500.77016346
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74123666
74Folate biosynthesis_Homo sapiens_hsa007900.71832574
75Histidine metabolism_Homo sapiens_hsa003400.70502328
76Rheumatoid arthritis_Homo sapiens_hsa053230.69875434
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69670722
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69546783
79Fatty acid biosynthesis_Homo sapiens_hsa000610.69322674
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68219828
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67767783
82MAPK signaling pathway_Homo sapiens_hsa040100.67638931
83Tryptophan metabolism_Homo sapiens_hsa003800.66859669
84Linoleic acid metabolism_Homo sapiens_hsa005910.66259265
85Peroxisome_Homo sapiens_hsa041460.65534978
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64232791
87Mismatch repair_Homo sapiens_hsa034300.62974724
88Pancreatic secretion_Homo sapiens_hsa049720.62808447
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62659089
90Ether lipid metabolism_Homo sapiens_hsa005650.61156199
91Dorso-ventral axis formation_Homo sapiens_hsa043200.60950526
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60469358
93Glioma_Homo sapiens_hsa052140.59425694
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.59162942
95Wnt signaling pathway_Homo sapiens_hsa043100.58735420
96Selenocompound metabolism_Homo sapiens_hsa004500.58351596
97Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58299757
98Purine metabolism_Homo sapiens_hsa002300.57696250
99Ras signaling pathway_Homo sapiens_hsa040140.56043691
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55139616
101Dilated cardiomyopathy_Homo sapiens_hsa054140.55091054
102Fatty acid elongation_Homo sapiens_hsa000620.54200815
103Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54099199
104Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53737709
105Caffeine metabolism_Homo sapiens_hsa002320.53436892
106Non-homologous end-joining_Homo sapiens_hsa034500.51927314
107Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51831655
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.51804199
109Type II diabetes mellitus_Homo sapiens_hsa049300.51110583
110Thyroid hormone synthesis_Homo sapiens_hsa049180.50977364
111Steroid hormone biosynthesis_Homo sapiens_hsa001400.50715013
112Choline metabolism in cancer_Homo sapiens_hsa052310.49677258
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49638485
114Renin-angiotensin system_Homo sapiens_hsa046140.49603609
115Sulfur relay system_Homo sapiens_hsa041220.49489853
116Autoimmune thyroid disease_Homo sapiens_hsa053200.48445562
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48443066
118Base excision repair_Homo sapiens_hsa034100.47594282
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47298217
120Endometrial cancer_Homo sapiens_hsa052130.46907577
121Retinol metabolism_Homo sapiens_hsa008300.46382679
122Glycerolipid metabolism_Homo sapiens_hsa005610.46227521
123Steroid biosynthesis_Homo sapiens_hsa001000.45300707
124Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.45039952
125Butanoate metabolism_Homo sapiens_hsa006500.44617621
126Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42897851
127Melanoma_Homo sapiens_hsa052180.41343052
128Alcoholism_Homo sapiens_hsa050340.40810312
129Metabolic pathways_Homo sapiens_hsa011000.40418293
130African trypanosomiasis_Homo sapiens_hsa051430.39810676
131Rap1 signaling pathway_Homo sapiens_hsa040150.39807079
132Phagosome_Homo sapiens_hsa041450.39124632
133Ovarian steroidogenesis_Homo sapiens_hsa049130.38434048
134Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36848042
135Colorectal cancer_Homo sapiens_hsa052100.35775628
136Sphingolipid signaling pathway_Homo sapiens_hsa040710.35690372
137Renal cell carcinoma_Homo sapiens_hsa052110.35105618
138Sphingolipid metabolism_Homo sapiens_hsa006000.34430084
139Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34283729
140Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31220126
141Regulation of autophagy_Homo sapiens_hsa041400.30376409
142Oocyte meiosis_Homo sapiens_hsa041140.28719796
143Circadian rhythm_Homo sapiens_hsa047100.27171383
144Prion diseases_Homo sapiens_hsa050200.25498801
145SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23718093
146Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.20802250
147Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.20423497

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »