IL1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to peptidoglycan (GO:0032494)6.16191002
2positive regulation of chemokine biosynthetic process (GO:0045080)6.02522545
3positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)5.90064526
4positive regulation of heat generation (GO:0031652)5.66940914
5regulation of fever generation (GO:0031620)5.66272537
6positive regulation of heterotypic cell-cell adhesion (GO:0034116)5.38069497
7regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)5.28626068
8regulation of chemokine biosynthetic process (GO:0045073)5.26113994
9lipopolysaccharide-mediated signaling pathway (GO:0031663)5.21976514
10positive regulation by symbiont of host defense response (GO:0052509)5.04162172
11modulation by symbiont of host defense response (GO:0052031)5.04162172
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.04162172
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.04162172
14positive regulation by organism of defense response of other organism involved in symbiotic interact5.04162172
15modulation by symbiont of host immune response (GO:0052553)5.04162172
16neutrophil activation involved in immune response (GO:0002283)4.77291092
17hydrogen peroxide biosynthetic process (GO:0050665)4.73541817
18regulation of membrane protein ectodomain proteolysis (GO:0051043)4.55496099
19regulation of vitamin D biosynthetic process (GO:0060556)4.53364636
20positive regulation of interferon-alpha production (GO:0032727)4.38218360
21positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.32531561
22regulation of heat generation (GO:0031650)4.30917760
23superoxide anion generation (GO:0042554)4.30330891
24regulation of activation of Janus kinase activity (GO:0010533)4.24294001
25positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.24023840
26cellular response to exogenous dsRNA (GO:0071360)4.23322387
27reactive oxygen species biosynthetic process (GO:1903409)4.18466418
28regulation of T-helper 1 cell differentiation (GO:0045625)4.17666004
29positive regulation of prostaglandin secretion (GO:0032308)4.15030344
30regulation of interferon-alpha production (GO:0032647)4.13257259
31regulation of prostaglandin secretion (GO:0032306)4.12480147
32negative regulation of interleukin-17 production (GO:0032700)4.09754973
33positive regulation of NF-kappaB import into nucleus (GO:0042346)4.09665901
34regulation of heterotypic cell-cell adhesion (GO:0034114)4.09116125
35antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.08873512
36cellular response to nicotine (GO:0071316)4.05086646
37granulocyte activation (GO:0036230)4.03442382
38regulation of vitamin metabolic process (GO:0030656)4.01887901
39cellular response to interferon-beta (GO:0035458)4.01122745
40macrophage activation involved in immune response (GO:0002281)3.99111010
41* regulation of vascular endothelial growth factor production (GO:0010574)3.93649268
42positive regulation of transcription factor import into nucleus (GO:0042993)3.91239914
43respiratory burst (GO:0045730)3.90578709
44production of molecular mediator involved in inflammatory response (GO:0002532)3.90353413
45leukocyte aggregation (GO:0070486)3.82436350
46eosinophil chemotaxis (GO:0048245)3.81354495
47regulation of cytokine secretion involved in immune response (GO:0002739)3.80224749
48positive regulation of nitric oxide biosynthetic process (GO:0045429)3.79651968
49negative regulation of lipid storage (GO:0010888)3.78305527
50regulation of histone phosphorylation (GO:0033127)3.73733515
51regulation of T-helper 2 cell differentiation (GO:0045628)3.69349421
52detection of molecule of bacterial origin (GO:0032490)3.67227546
53regulation of lymphocyte chemotaxis (GO:1901623)3.66390901
54positive regulation of mast cell activation involved in immune response (GO:0033008)3.65722470
55positive regulation of mast cell degranulation (GO:0043306)3.65722470
56negative regulation by host of viral transcription (GO:0043922)3.62925882
57positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.61792146
58cellular response to lipopolysaccharide (GO:0071222)3.55355668
59negative regulation of viral genome replication (GO:0045071)3.53858013
60positive regulation of lymphocyte migration (GO:2000403)3.53693686
61positive regulation of cellular amide metabolic process (GO:0034250)3.53052837
62regulation of interleukin-17 production (GO:0032660)3.52026085
63NIK/NF-kappaB signaling (GO:0038061)3.49610041
64regulation of interferon-beta biosynthetic process (GO:0045357)3.48243314
65positive regulation of T-helper cell differentiation (GO:0045624)3.47876437
66immunoglobulin mediated immune response (GO:0016064)3.47708014
67response to muramyl dipeptide (GO:0032495)3.47262419
68positive regulation of chemokine production (GO:0032722)3.44983923
69negative regulation of glucose transport (GO:0010829)3.42720908
70positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.42694336
71response to protozoan (GO:0001562)3.41365787
72eosinophil migration (GO:0072677)3.40654094
73cellular response to molecule of bacterial origin (GO:0071219)3.40187628
74* positive regulation vascular endothelial growth factor production (GO:0010575)3.39438937
75response to host immune response (GO:0052572)3.39217934
76response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.39217934
77regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.39051152
78positive regulation of steroid biosynthetic process (GO:0010893)3.38515880
79response to interferon-beta (GO:0035456)3.36253473
80regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.36045902
81regulation of interleukin-12 biosynthetic process (GO:0045075)3.35017613
82positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.34936335
83* positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.32880532
84positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.32092520
85regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.32092520
86regulation of mononuclear cell migration (GO:0071675)3.31679771
87monocyte chemotaxis (GO:0002548)3.31576067
88neutrophil activation (GO:0042119)3.30657108
89negative regulation of amino acid transport (GO:0051956)3.29714114
90T-helper 1 type immune response (GO:0042088)3.29661683
91regulation of podosome assembly (GO:0071801)3.28749536
92myeloid cell activation involved in immune response (GO:0002275)3.25946928
93regulation of chronic inflammatory response (GO:0002676)3.25851521
94positive regulation of type 2 immune response (GO:0002830)3.24816073
95positive regulation of interleukin-6 production (GO:0032755)3.22439927
96microglial cell activation (GO:0001774)3.22369514
97regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.21858994
98negative regulation of interleukin-12 production (GO:0032695)3.19889009
99lymphocyte chemotaxis (GO:0048247)3.19510728
100negative regulation of cytokine production involved in immune response (GO:0002719)3.19443813
101positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.19299311
102positive regulation of interleukin-12 production (GO:0032735)3.19028675
103positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)3.16697648
104positive regulation of alpha-beta T cell proliferation (GO:0046641)3.16538806
105positive regulation of interleukin-10 production (GO:0032733)3.15066370
106positive regulation of tumor necrosis factor production (GO:0032760)3.14764942
107defense response to protozoan (GO:0042832)3.14416033
108positive regulation of interferon-beta production (GO:0032728)3.13378712
109positive regulation of acute inflammatory response (GO:0002675)3.13153726
110neutrophil chemotaxis (GO:0030593)3.12866163
111regulation of interleukin-6 biosynthetic process (GO:0045408)3.12515272
112T cell migration (GO:0072678)3.11854450
113regulation of nitric oxide biosynthetic process (GO:0045428)3.11491017
114response to ATP (GO:0033198)3.10318362
115positive regulation of mast cell activation (GO:0033005)3.09607749
116regulation of T cell cytokine production (GO:0002724)3.07078228
117natural killer cell activation involved in immune response (GO:0002323)3.06685108
118regulation of immunoglobulin secretion (GO:0051023)3.06138514
119positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.05640969
120neutrophil mediated immunity (GO:0002446)3.05423130
121neutrophil migration (GO:1990266)3.04327042
122negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.03694938
123regulation of mast cell degranulation (GO:0043304)3.03606201
124regulation of NF-kappaB import into nucleus (GO:0042345)3.02847782
125germinal center formation (GO:0002467)3.00502735
126positive regulation of interleukin-17 production (GO:0032740)2.99927403
127regulation of interleukin-6 production (GO:0032675)2.97898275
128negative regulation of interleukin-1 beta production (GO:0032691)2.97017723
129cellular response to biotic stimulus (GO:0071216)2.96863992
130response to manganese ion (GO:0010042)2.96458515
131interleukin-1-mediated signaling pathway (GO:0070498)2.95852954
132positive regulation of hair follicle development (GO:0051798)2.92553958
133positive regulation of hair cycle (GO:0042635)2.92553958
134activation of MAPKKK activity (GO:0000185)2.92270293
135regulation of interleukin-8 biosynthetic process (GO:0045414)2.89019224
136hemidesmosome assembly (GO:0031581)2.79580816
137CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.79383018
138regulation of T-helper cell differentiation (GO:0045622)2.79029400
139positive regulation of monooxygenase activity (GO:0032770)2.78156823
140negative regulation of cytokine secretion (GO:0050710)2.77895110
141regulation of integrin activation (GO:0033623)2.76720999
142negative regulation of alcohol biosynthetic process (GO:1902931)2.76529380
143interleukin-6-mediated signaling pathway (GO:0070102)2.75518659
144positive regulation of protein export from nucleus (GO:0046827)2.73419412
145cellular response to ATP (GO:0071318)2.71200761
146positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.68013607
147decidualization (GO:0046697)2.65019528
148regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.62054041

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse6.85342252
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.71770163
3IRF8_27001747_Chip-Seq_BMDM_Mouse4.10495230
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.80507390
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.77443722
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.69668768
7* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.62956968
8Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.61403207
9* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.35725303
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.91341072
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.75779921
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.62790124
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.60022202
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.53942550
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.45653818
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.40197055
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.26198573
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.18537294
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.12524920
20BP1_19119308_ChIP-ChIP_Hs578T_Human11.6266296
21PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.87289930
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.84823665
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.82424303
24VDR_24787735_ChIP-Seq_THP-1_Human1.71387018
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.68598977
26PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.67622366
27BRD4_27068464_Chip-Seq_AML-cells_Mouse1.63017868
28SPI1_23547873_ChIP-Seq_NB4_Human1.58963293
29CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.58408372
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.54918265
31CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.52100253
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.50959989
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.47052393
34ELK3_25401928_ChIP-Seq_HUVEC_Human1.44441851
35PU_27001747_Chip-Seq_BMDM_Mouse1.44210123
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38407448
37GATA1_22025678_ChIP-Seq_K562_Human1.32488381
38UBF1/2_26484160_Chip-Seq_HMECs_Human1.30631632
39CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30502239
40VDR_24763502_ChIP-Seq_THP-1_Human1.29124563
41VDR_21846776_ChIP-Seq_THP-1_Human1.26084529
42RUNX_20019798_ChIP-Seq_JUKART_Human1.25686679
43CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21507982
44RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.19328599
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19278328
46NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19068648
47NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19068648
48PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18494095
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.18263992
50MYB_26560356_Chip-Seq_TH2_Human1.15005421
51TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14084405
52SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12585103
53ATF3_27146783_Chip-Seq_COLON_Human1.12281664
54KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10492893
55TCF7_22412390_ChIP-Seq_EML_Mouse1.08973281
56SPI1_23127762_ChIP-Seq_K562_Human1.08618067
57RUNX1_22412390_ChIP-Seq_EML_Mouse1.08542466
58PPAR_26484153_Chip-Seq_NCI-H1993_Human1.08062948
59LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.07810260
60CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.03701027
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03558203
62KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01549223
63GATA3_26560356_Chip-Seq_TH2_Human1.00817372
64SOX2_20726797_ChIP-Seq_SW620_Human0.99940107
65SCL_19346495_ChIP-Seq_HPC-7_Human0.98475285
66SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97842583
67FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.97500590
68TP63_17297297_ChIP-ChIP_HaCaT_Human0.97357970
69FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.97254509
70* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97166494
71GATA2_21666600_ChIP-Seq_HMVEC_Human0.96897531
72PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95694223
73LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.94658780
74CLOCK_20551151_ChIP-Seq_293T_Human0.94055604
75GATA3_27048872_Chip-Seq_THYMUS_Human0.91219444
76ESR1_21235772_ChIP-Seq_MCF-7_Human0.91122843
77RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90680881
78TP53_16413492_ChIP-PET_HCT116_Human0.87941317
79CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.87702014
80JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86732146
81* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86517064
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86489083
83PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.86467283
84ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.86023220
85TRIM28_21343339_ChIP-Seq_HEK293_Human0.85488928
86NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.85279148
87EGR1_23403033_ChIP-Seq_LIVER_Mouse0.84524158
88GATA1_19941826_ChIP-Seq_K562_Human0.84515454
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83743174
90TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83243050
91* TP63_23658742_ChIP-Seq_EP156T_Human0.82896097
92* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.82622030
93HIF1A_21447827_ChIP-Seq_MCF-7_Human0.82615785
94JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82294764
95KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.80464464
96CJUN_26792858_Chip-Seq_BT549_Human0.80455179
97GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79865485
98KDM2B_26808549_Chip-Seq_DND41_Human0.78487121
99EGR1_19032775_ChIP-ChIP_M12_Human0.77762587
100GATA2_22383799_ChIP-Seq_G1ME_Mouse0.76974052
101FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.73814051
102SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.73280216
103MYB_26560356_Chip-Seq_TH1_Human0.70405282
104MAF_26560356_Chip-Seq_TH1_Human0.70266064
105ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.67596217
106STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.66186737
107CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.64728788
108FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.64549158
109CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.64181096
110CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.63262394
111SPI1_20517297_ChIP-Seq_HL60_Human0.59650857
112* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.58880108
113* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.58880108
114SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.58195396
115TP53_18474530_ChIP-ChIP_U2OS_Human0.57576005
116GATA2_19941826_ChIP-Seq_K562_Human0.57304040
117RARG_19884340_ChIP-ChIP_MEFs_Mouse0.57273140
118SALL4_22934838_ChIP-ChIP_CD34+_Human0.55413759
119SALL4_18804426_ChIP-ChIP_XEN_Mouse0.55247967
120CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.54925933
121P63_26484246_Chip-Seq_KERATINOCYTES_Human0.54194394
122LXR_22158963_ChIP-Seq_LIVER_Mouse0.53626257
123SMRT_27268052_Chip-Seq_Bcells_Human0.52112509
124E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.50665904
125RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.49787790
126GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.48966926
127RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.47806437

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006082_CNS_inflammation5.20633259
2MP0009785_altered_susceptibility_to4.95162469
3MP0003724_increased_susceptibility_to4.29525970
4MP0001835_abnormal_antigen_presentation4.02406801
5* MP0002148_abnormal_hypersensitivity_rea3.96668087
6MP0003436_decreased_susceptibility_to3.94841137
7* MP0005000_abnormal_immune_tolerance3.52428425
8* MP0002419_abnormal_innate_immunity3.43204613
9MP0005025_abnormal_response_to3.30917623
10MP0003303_peritoneal_inflammation3.25159195
11MP0009764_decreased_sensitivity_to2.81225171
12MP0005167_abnormal_blood-brain_barrier2.63518816
13MP0002452_abnormal_antigen_presenting2.55510561
14* MP0002723_abnormal_immune_serum2.47921201
15MP0005671_abnormal_response_to2.26679171
16MP0004947_skin_inflammation2.26337056
17MP0001533_abnormal_skeleton_physiology2.24050991
18MP0001800_abnormal_humoral_immune2.21752208
19MP0001790_abnormal_immune_system2.17630988
20MP0005387_immune_system_phenotype2.17630988
21MP0004510_myositis2.15406922
22MP0001853_heart_inflammation2.15087510
23MP0003300_gastrointestinal_ulcer2.13743705
24MP0005464_abnormal_platelet_physiology2.12139066
25MP0003075_altered_response_to2.12006285
26MP0009278_abnormal_bone_marrow2.08637536
27MP0005058_abnormal_lysosome_morphology2.05741924
28* MP0001819_abnormal_immune_cell2.05425952
29MP0000685_abnormal_immune_system2.04569194
30MP0001845_abnormal_inflammatory_respons2.02548511
31* MP0002420_abnormal_adaptive_immunity2.01590300
32MP0003448_altered_tumor_morphology1.96134196
33* MP0008469_abnormal_protein_level1.85317928
34MP0005166_decreased_susceptibility_to1.77691707
35MP0003195_calcinosis1.75078259
36MP0002405_respiratory_system_inflammati1.74942181
37MP0003690_abnormal_glial_cell1.74763593
38MP0002998_abnormal_bone_remodeling1.65084798
39MP0000343_altered_response_to1.64484274
40MP0010155_abnormal_intestine_physiology1.62505432
41MP0003705_abnormal_hypodermis_morpholog1.58333522
42MP0005164_abnormal_response_to1.57036401
43MP0003828_pulmonary_edema1.56035278
44MP0009333_abnormal_splenocyte_physiolog1.51842200
45MP0003191_abnormal_cellular_cholesterol1.50063881
46MP0002139_abnormal_hepatobiliary_system1.38735936
47MP0003186_abnormal_redox_activity1.37297536
48* MP0002006_tumorigenesis1.36826079
49MP0005023_abnormal_wound_healing1.36186323
50MP0000716_abnormal_immune_system1.33469647
51MP0001216_abnormal_epidermal_layer1.32948209
52MP0003806_abnormal_nucleotide_metabolis1.30220849
53MP0003646_muscle_fatigue1.30022848
54MP0005451_abnormal_body_composition1.26194229
55MP0006054_spinal_hemorrhage1.25008459
56MP0008004_abnormal_stomach_pH1.24528186
57MP0000604_amyloidosis1.23560950
58* MP0000858_altered_metastatic_potential1.23436335
59MP0002332_abnormal_exercise_endurance1.21475061
60MP0005310_abnormal_salivary_gland1.20564116
61MP0010234_abnormal_vibrissa_follicle1.19345803
62MP0003172_abnormal_lysosome_physiology1.18635695
63MP0002277_abnormal_respiratory_mucosa1.18196154
64MP0005397_hematopoietic_system_phenotyp1.16593678
65MP0001545_abnormal_hematopoietic_system1.16593678
66MP0002398_abnormal_bone_marrow1.11388371
67MP0009763_increased_sensitivity_to1.10717995
68MP0005390_skeleton_phenotype1.05786619
69MP0003453_abnormal_keratinocyte_physiol1.04943637
70MP0000579_abnormal_nail_morphology1.04067472
71MP0002877_abnormal_melanocyte_morpholog1.03893358
72MP0002429_abnormal_blood_cell1.01657674
73MP0010352_gastrointestinal_tract_polyps1.00141591
74MP0004883_abnormal_blood_vessel0.99641007
75MP0001849_ear_inflammation0.96280375
76MP0002254_reproductive_system_inflammat0.95669994
77MP0003950_abnormal_plasma_membrane0.93384801
78MP0000920_abnormal_myelination0.92863807
79MP0002933_joint_inflammation0.91466226
80MP0004782_abnormal_surfactant_physiolog0.88080197
81MP0000689_abnormal_spleen_morphology0.87873901
82MP0001501_abnormal_sleep_pattern0.86390275
83MP0008260_abnormal_autophagy0.84184720
84MP0001727_abnormal_embryo_implantation0.82853455
85MP0002722_abnormal_immune_system0.82635046
86MP0000249_abnormal_blood_vessel0.81676895
87MP0001851_eye_inflammation0.80830317
88MP0002060_abnormal_skin_morphology0.80610756
89MP0000750_abnormal_muscle_regeneration0.79791201
90MP0003566_abnormal_cell_adhesion0.79691306
91MP0002796_impaired_skin_barrier0.77597958
92MP0000569_abnormal_digit_pigmentation0.75306512
93MP0004484_altered_response_of0.73920450
94MP0010678_abnormal_skin_adnexa0.73705840
95MP0003656_abnormal_erythrocyte_physiolo0.73037373
96MP0009840_abnormal_foam_cell0.72174825
97MP0001663_abnormal_digestive_system0.71693012
98MP0004808_abnormal_hematopoietic_stem0.69557735
99MP0009765_abnormal_xenobiotic_induced0.69095677
100MP0008874_decreased_physiological_sensi0.68602932
101MP0000465_gastrointestinal_hemorrhage0.68263898
102MP0003795_abnormal_bone_structure0.67794628
103MP0005266_abnormal_metabolism0.66826984
104* MP0005535_abnormal_body_temperature0.64051918
105MP0005076_abnormal_cell_differentiation0.63500023
106MP0000371_diluted_coat_color0.63327001
107MP0002136_abnormal_kidney_physiology0.60094179
108MP0001191_abnormal_skin_condition0.59363842
109MP0010386_abnormal_urinary_bladder0.58980387
110MP0008873_increased_physiological_sensi0.58768627
111MP0002693_abnormal_pancreas_physiology0.57497795
112MP0004858_abnormal_nervous_system0.51975963
113MP0004130_abnormal_muscle_cell0.49270273
114MP0005165_increased_susceptibility_to0.47090627
115MP0003045_fibrosis0.46691596
116MP0005319_abnormal_enzyme/_coenzyme0.46603763
117MP0002295_abnormal_pulmonary_circulatio0.45518378
118MP0002138_abnormal_hepatobiliary_system0.44457599
119MP0002090_abnormal_vision0.43615963
120MP0005171_absent_coat_pigmentation0.41046549
121MP0005174_abnormal_tail_pigmentation0.40755218
122MP0003136_yellow_coat_color0.39377063
123MP0003091_abnormal_cell_migration0.39237928
124MP0002168_other_aberrant_phenotype0.38191790
125MP0000609_abnormal_liver_physiology0.37104081
126MP0000767_abnormal_smooth_muscle0.37010292

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)8.24625662
2Eczematoid dermatitis (HP:0000976)7.82394888
3Recurrent bacterial skin infections (HP:0005406)7.47326279
4Recurrent gram-negative bacterial infections (HP:0005420)7.28199968
5Mediastinal lymphadenopathy (HP:0100721)6.39238878
6Stomatitis (HP:0010280)6.19947131
7Abnormality of macrophages (HP:0004311)5.24262873
8Retrobulbar optic neuritis (HP:0100654)5.05848051
9Optic neuritis (HP:0100653)5.05848051
10Elevated erythrocyte sedimentation rate (HP:0003565)5.01947867
11Orchitis (HP:0100796)4.86462711
12Gingivitis (HP:0000230)4.70155327
13Myositis (HP:0100614)4.42372342
14Systemic lupus erythematosus (HP:0002725)4.41750576
15Recurrent skin infections (HP:0001581)4.39599544
16Amyloidosis (HP:0011034)4.24650733
17Obstructive lung disease (HP:0006536)4.09022545
18Chronic obstructive pulmonary disease (HP:0006510)4.09022545
19Autoimmune thrombocytopenia (HP:0001973)4.07212877
20Interstitial pulmonary disease (HP:0006530)4.01384580
21Onycholysis (HP:0001806)3.87515935
22Vasculitis (HP:0002633)3.86007130
23Milia (HP:0001056)3.76766914
24Plantar hyperkeratosis (HP:0007556)3.59859554
25Recurrent fungal infections (HP:0002841)3.59458214
26Increased neuronal autofluorescent lipopigment (HP:0002074)3.52028598
27Abnormality of nail color (HP:0100643)3.47289750
28Neurofibrillary tangles (HP:0002185)3.42058258
29Basal ganglia calcification (HP:0002135)3.42020039
30Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.40649577
31Episodic fever (HP:0001954)3.39832541
32Increased cerebral lipofuscin (HP:0011813)3.38601389
33Axonal loss (HP:0003447)3.28937295
34Prostate neoplasm (HP:0100787)3.25175796
35Pulmonary infiltrates (HP:0002113)3.23441667
36Vacuolated lymphocytes (HP:0001922)3.17502788
37Periodontitis (HP:0000704)3.16051522
38Alopecia of scalp (HP:0002293)3.11614967
39Increased IgM level (HP:0003496)3.06518754
40Recurrent viral infections (HP:0004429)3.04911795
41Loss of speech (HP:0002371)3.04259245
42Urticaria (HP:0001025)2.96668728
43Thick nail (HP:0001805)2.93113308
44Cellulitis (HP:0100658)2.92749043
45Pustule (HP:0200039)2.90060865
46Fragile nails (HP:0001808)2.89102521
47Keratoconjunctivitis sicca (HP:0001097)2.87774021
48Nail dystrophy (HP:0008404)2.85209183
49Tetraparesis (HP:0002273)2.85166957
50Poor head control (HP:0002421)2.84986224
51Palmoplantar hyperkeratosis (HP:0000972)2.80831521
52Atrophic scars (HP:0001075)2.80389306
53Disinhibition (HP:0000734)2.80165111
54Glomerulonephritis (HP:0000099)2.76547925
55Abnormality of the pericardium (HP:0001697)2.75591692
56Meningitis (HP:0001287)2.71836457
57Nausea (HP:0002018)2.71100578
58Progressive sensorineural hearing impairment (HP:0000408)2.68991157
59Chronic mucocutaneous candidiasis (HP:0002728)2.67941278
60Recurrent cutaneous fungal infections (HP:0011370)2.67941278
61Recurrent pneumonia (HP:0006532)2.67879491
62Petechiae (HP:0000967)2.64291064
63Keratoconjunctivitis (HP:0001096)2.62447087
64Oral leukoplakia (HP:0002745)2.61202812
65Palmar hyperkeratosis (HP:0010765)2.59759490
66Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.58752060
67Purpura (HP:0000979)2.55384524
68Premature loss of primary teeth (HP:0006323)2.54120963
69Abnormal blistering of the skin (HP:0008066)2.53320280
70Arterial thrombosis (HP:0004420)2.49891977
71Parakeratosis (HP:0001036)2.49069793
72Ridged nail (HP:0001807)2.42607390
73Polyneuropathy (HP:0001271)2.41154971
74Cerebral inclusion bodies (HP:0100314)2.40860088
75Apathy (HP:0000741)2.39621327
76Joint swelling (HP:0001386)2.39168003
77Nephritis (HP:0000123)2.38986548
78Hemoptysis (HP:0002105)2.36463759
79Abnormality of glycolipid metabolism (HP:0010969)2.36034825
80Abnormality of liposaccharide metabolism (HP:0010968)2.36034825
81Abnormality of glycosphingolipid metabolism (HP:0004343)2.36034825
82Recurrent lower respiratory tract infections (HP:0002783)2.33325208
83Hemorrhage of the eye (HP:0011885)2.32406481
84Osteomyelitis (HP:0002754)2.29414532
85Diminished motivation (HP:0000745)2.29380081
86Abnormality of the pleura (HP:0002103)2.28708342
87Hypergammaglobulinemia (HP:0010702)2.28516947
88Hepatosplenomegaly (HP:0001433)2.27365095
89Leukocytosis (HP:0001974)2.26374836
90Joint hemorrhage (HP:0005261)2.25058158
91Porencephaly (HP:0002132)2.24906727
92Myocardial infarction (HP:0001658)2.24310621
93Agnosia (HP:0010524)2.22696352
94Gingival bleeding (HP:0000225)2.17423797
95Fused cervical vertebrae (HP:0002949)2.16007036
96Bone pain (HP:0002653)2.15430517
97Amniotic constriction ring (HP:0009775)2.14920202
98Abnormality of placental membranes (HP:0011409)2.14920202
99Lower limb hyperreflexia (HP:0002395)2.13447552
100Arthralgia (HP:0002829)2.12301452
101Esophageal neoplasm (HP:0100751)2.11954057
102Neoplasm of head and neck (HP:0012288)2.11954057
103Malnutrition (HP:0004395)2.10637702
104Xerostomia (HP:0000217)2.08044943
105Gastrointestinal stroma tumor (HP:0100723)2.07841793
106Prolonged neonatal jaundice (HP:0006579)2.07078636
107Gastrointestinal infarctions (HP:0005244)2.07013566
108Thin bony cortex (HP:0002753)2.04424555
109Gangrene (HP:0100758)2.03325254
110Restrictive lung disease (HP:0002091)2.02602013
111Increased IgE level (HP:0003212)1.99717329
112Neuronal loss in central nervous system (HP:0002529)1.98892962
113Mutism (HP:0002300)1.98093663
114Nuclear cataract (HP:0100018)1.97740941
115Abnormality of mucopolysaccharide metabolism (HP:0011020)1.97601288
116Abnormality of polysaccharide metabolism (HP:0011012)1.97601288
117Abnormality of glycosaminoglycan metabolism (HP:0004371)1.97601288
118Progressive visual loss (HP:0000529)1.96319026
119Sepsis (HP:0100806)1.96096653
120Anorexia (HP:0002039)1.93946771
121Pruritus (HP:0000989)1.92587954
122Hypoplasia of dental enamel (HP:0006297)1.92476345
123Pathologic fracture (HP:0002756)1.90979497
124Metaphyseal irregularity (HP:0003025)1.90191534
125Segmental peripheral demyelination/remyelination (HP:0003481)1.89744809
126Pigmentary retinal degeneration (HP:0001146)1.87728122
127Abnormality of the prostate (HP:0008775)1.87056724
128Peritonitis (HP:0002586)1.86710603
129Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.85629710
130Osteolytic defects of the hand bones (HP:0009699)1.83541993
131Osteolytic defects of the phalanges of the hand (HP:0009771)1.83541993
132Progressive neurologic deterioration (HP:0002344)1.83140668
133Progressive hearing impairment (HP:0001730)1.82783218
134Abnormality of iron homeostasis (HP:0011031)1.82748252
135Autoimmune hemolytic anemia (HP:0001890)1.82263773
136Dysostosis multiplex (HP:0000943)1.82050554
137Aplasia cutis congenita (HP:0001057)1.81554076
138Mucopolysacchariduria (HP:0008155)1.78517127
139Hematochezia (HP:0002573)1.76710143
140Vertebral compression fractures (HP:0002953)1.74127783
141Lymphopenia (HP:0001888)1.71539234
142Increased serum ferritin (HP:0003281)1.71047528
143Skin ulcer (HP:0200042)1.70818304
144Abnormality of T cell number (HP:0011839)1.69918024

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.77135641
2BLK5.13098312
3PBK4.94472631
4MAP3K144.84394964
5TBK13.62561337
6IRAK33.39270890
7TXK3.23165719
8IRAK42.87063928
9IKBKB2.49381197
10IKBKE2.28690454
11TAOK22.18763380
12MAP3K132.10071640
13MAP4K12.01128304
14JAK31.94830373
15TYK21.80959818
16MAP3K31.79354266
17LATS21.77634473
18BMPR21.72327752
19MAP3K91.70180338
20FGR1.65288888
21STK241.65065914
22PIM21.64848083
23CHUK1.62534232
24TAOK11.62080590
25CSK1.59787495
26MAP3K121.57425170
27BMX1.44044353
28JAK11.43117106
29MST1R1.41523612
30PRPF4B1.39071139
31TAOK31.29624455
32ABL21.25626019
33ERBB41.24275406
34PDGFRA1.23896166
35LYN1.22363865
36CDC42BPA1.21128829
37MST41.19489883
38YES11.19486208
39ERN11.18638840
40ZAP701.16654131
41MATK1.14924415
42MARK31.14253944
43IRAK21.13511592
44SYK1.08269238
45EIF2AK21.05704249
46RPS6KA41.03939435
47TYRO31.02954467
48IRAK11.02908460
49MAP3K51.02740425
50PIM11.01691990
51KIT1.00973452
52ADRBK21.00119794
53HCK0.99220126
54JAK20.95338685
55GRK70.94875686
56LCK0.86127065
57PRKCD0.82599372
58CSF1R0.77607837
59NME20.75899312
60ARAF0.73985494
61STK40.73442121
62PAK40.73341202
63NEK90.71230332
64BTK0.69421443
65EPHB10.66432431
66MAP3K110.65989305
67ABL10.63867202
68STK100.61704670
69ERBB30.59878752
70EGFR0.52448091
71RIPK10.50993197
72TESK10.50424818
73TEC0.47690757
74PRKCQ0.45315787
75MUSK0.45177971
76KSR10.44926448
77EPHA30.43809705
78MAP3K10.43293021
79BMPR1B0.42835137
80PDPK10.42337076
81FYN0.42056547
82MAP3K100.41898996
83PDK20.39837584
84KSR20.37387188
85DAPK30.36742506
86BRAF0.36372938
87PDK10.35946905
88FES0.35060806
89TTN0.34737794
90EPHA20.34213613
91FGFR30.33814308
92SIK30.33650354
93ADRBK10.33622693
94STK30.32524056
95TGFBR10.32072008
96LRRK20.30759005
97SIK10.30396123
98NLK0.30230913
99TGFBR20.29430176
100STK38L0.28445635
101PKN10.28424578
102IGF1R0.27334215
103CDK60.26693022
104EPHB20.26626743
105FGFR40.26257156
106DDR20.25753001
107TRPM70.24008042
108MET0.23385957
109PRKCZ0.23042370
110PDGFRB0.22600445
111INSR0.21924749
112MOS0.21360406
113MAPK40.20352158
114DYRK30.20204113
115MAPKAPK20.20165598
116CLK10.19815612
117ACVR1B0.19634022
118MAP3K80.19299150
119PIK3CG0.18764161
120RPS6KC10.17417608
121RPS6KL10.17417608
122SGK30.17043251
123GSK3A0.16554479
124PRKCE0.16464178
125PLK20.15598632
126ITK0.14958921
127MAP2K30.13854810
128MAP2K60.11097288
129RPS6KA10.10699412
130MAPK70.10568975
131SRC0.10538971
132PRKCH0.10161488
133RPS6KA60.08540424
134RAF10.07779208
135PTK20.07368796
136HIPK20.07363044

Predicted pathways (KEGG)

RankGene SetZ-score
1* Graft-versus-host disease_Homo sapiens_hsa053324.17735712
2Legionellosis_Homo sapiens_hsa051343.79916814
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.37857711
4* Leishmaniasis_Homo sapiens_hsa051403.34329888
5Toll-like receptor signaling pathway_Homo sapiens_hsa046203.26600256
6NOD-like receptor signaling pathway_Homo sapiens_hsa046213.23300486
7Staphylococcus aureus infection_Homo sapiens_hsa051503.11907020
8Allograft rejection_Homo sapiens_hsa053303.01442332
9* Rheumatoid arthritis_Homo sapiens_hsa053232.91268502
10* Type I diabetes mellitus_Homo sapiens_hsa049402.85676536
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.85649236
12Malaria_Homo sapiens_hsa051442.64803800
13* Pertussis_Homo sapiens_hsa051332.51509956
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.44901125
15African trypanosomiasis_Homo sapiens_hsa051432.38334932
16* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.38148495
17* Salmonella infection_Homo sapiens_hsa051322.37868520
18* Tuberculosis_Homo sapiens_hsa051522.33810865
19TNF signaling pathway_Homo sapiens_hsa046682.25868430
20Asthma_Homo sapiens_hsa053102.16381210
21* Osteoclast differentiation_Homo sapiens_hsa043801.99100980
22* Measles_Homo sapiens_hsa051621.84766160
23* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.69304258
24Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.64081161
25* Influenza A_Homo sapiens_hsa051641.63828083
26Phagosome_Homo sapiens_hsa041451.58494805
27* Hematopoietic cell lineage_Homo sapiens_hsa046401.54752658
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.48484662
29Herpes simplex infection_Homo sapiens_hsa051681.41627926
30Bladder cancer_Homo sapiens_hsa052191.39017201
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.35462102
32Chemokine signaling pathway_Homo sapiens_hsa040621.34363705
33Amoebiasis_Homo sapiens_hsa051461.27970483
34Lysosome_Homo sapiens_hsa041421.21142751
35Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.16949679
36Toxoplasmosis_Homo sapiens_hsa051451.16598463
37Autoimmune thyroid disease_Homo sapiens_hsa053201.13953460
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.11754326
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.04426806
40* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91978400
41Collecting duct acid secretion_Homo sapiens_hsa049660.91514917
42B cell receptor signaling pathway_Homo sapiens_hsa046620.91042892
43Apoptosis_Homo sapiens_hsa042100.90327270
44Hepatitis B_Homo sapiens_hsa051610.87796402
45Shigellosis_Homo sapiens_hsa051310.84238447
46* Prion diseases_Homo sapiens_hsa050200.82768979
47Hepatitis C_Homo sapiens_hsa051600.82215054
48Complement and coagulation cascades_Homo sapiens_hsa046100.77004748
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74963978
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70356684
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67851009
52Antigen processing and presentation_Homo sapiens_hsa046120.62339850
53Viral myocarditis_Homo sapiens_hsa054160.59448201
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56909044
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55561360
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54699953
57Mineral absorption_Homo sapiens_hsa049780.53176028
58T cell receptor signaling pathway_Homo sapiens_hsa046600.52632784
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.52189363
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46372352
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.45087191
62Other glycan degradation_Homo sapiens_hsa005110.44142816
63Renal cell carcinoma_Homo sapiens_hsa052110.43151826
64Type II diabetes mellitus_Homo sapiens_hsa049300.43047834
65Fatty acid biosynthesis_Homo sapiens_hsa000610.42757607
66Sulfur metabolism_Homo sapiens_hsa009200.40577731
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40195929
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.39849647
69PPAR signaling pathway_Homo sapiens_hsa033200.37709597
70ErbB signaling pathway_Homo sapiens_hsa040120.37014779
71Primary immunodeficiency_Homo sapiens_hsa053400.32544350
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.29876933
73Platelet activation_Homo sapiens_hsa046110.29618761
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29189728
75Acute myeloid leukemia_Homo sapiens_hsa052210.28994767
76HIF-1 signaling pathway_Homo sapiens_hsa040660.28252657
77Vibrio cholerae infection_Homo sapiens_hsa051100.27871845
78Epstein-Barr virus infection_Homo sapiens_hsa051690.27296351
79Galactose metabolism_Homo sapiens_hsa000520.26698605
80MicroRNAs in cancer_Homo sapiens_hsa052060.26569674
81Steroid biosynthesis_Homo sapiens_hsa001000.25237827
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.24565556
83Notch signaling pathway_Homo sapiens_hsa043300.23548561
84Prolactin signaling pathway_Homo sapiens_hsa049170.20712871
85Dorso-ventral axis formation_Homo sapiens_hsa043200.18598974
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.18460962
87Chronic myeloid leukemia_Homo sapiens_hsa052200.17675550
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.17572478
89Prostate cancer_Homo sapiens_hsa052150.17011782
90GnRH signaling pathway_Homo sapiens_hsa049120.16496085
91Pathways in cancer_Homo sapiens_hsa052000.15840376
92Insulin resistance_Homo sapiens_hsa049310.14580719
93* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.13614756
94Pancreatic cancer_Homo sapiens_hsa052120.13152736
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.12801464
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.12166770
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.10435783
98Synaptic vesicle cycle_Homo sapiens_hsa047210.10418827
99Proteoglycans in cancer_Homo sapiens_hsa052050.07916310
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.07448727
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.07222056
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.06894877
103Proteasome_Homo sapiens_hsa030500.06768271
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.05680777
105Small cell lung cancer_Homo sapiens_hsa052220.05351511
106Arachidonic acid metabolism_Homo sapiens_hsa005900.05349777
107FoxO signaling pathway_Homo sapiens_hsa040680.04419429
108VEGF signaling pathway_Homo sapiens_hsa043700.02995085
109* MAPK signaling pathway_Homo sapiens_hsa040100.02430275
110Endocytosis_Homo sapiens_hsa041440.00277129
111Arginine biosynthesis_Homo sapiens_hsa00220-0.0259409
112Sphingolipid metabolism_Homo sapiens_hsa00600-0.0191582
113Ether lipid metabolism_Homo sapiens_hsa00565-0.0159097
114Viral carcinogenesis_Homo sapiens_hsa05203-0.0093946
115HTLV-I infection_Homo sapiens_hsa05166-0.0092044

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