IL17REL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1NIK/NF-kappaB signaling (GO:0038061)5.90249311
2positive regulation of Cdc42 GTPase activity (GO:0043089)5.76476902
3regulation of dendritic cell antigen processing and presentation (GO:0002604)5.19093985
4positive regulation of antigen processing and presentation (GO:0002579)5.06755734
5positive regulation of protein kinase C signaling (GO:0090037)4.69481841
6ear development (GO:0043583)4.69153627
7regulation of T cell differentiation in thymus (GO:0033081)4.68190636
8regulation of antigen processing and presentation (GO:0002577)4.53505120
9positive regulation of histone deacetylation (GO:0031065)4.51458739
10glomerular filtration (GO:0003094)4.44127250
11endothelial cell chemotaxis (GO:0035767)4.43188040
12regulation of endothelial cell chemotaxis (GO:2001026)4.20331511
13germinal center formation (GO:0002467)4.16707424
14regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.09755776
15semaphorin-plexin signaling pathway (GO:0071526)4.02812722
16negative regulation of erythrocyte differentiation (GO:0045647)4.02331571
17renal filtration (GO:0097205)3.96862065
18desmosome organization (GO:0002934)3.88059333
19positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.87957983
20regulation of T-helper 1 cell differentiation (GO:0045625)3.75830549
21phospholipid scrambling (GO:0017121)3.75031183
22histone H3-K36 demethylation (GO:0070544)3.74648762
23regulation of ARF protein signal transduction (GO:0032012)3.74106735
24mitotic G1 DNA damage checkpoint (GO:0031571)3.73018562
25G1 DNA damage checkpoint (GO:0044783)3.71926283
26hair follicle development (GO:0001942)3.69955843
27regulation of histone deacetylation (GO:0031063)3.63355907
28positive regulation of neutrophil migration (GO:1902624)3.62731981
29positive regulation of neutrophil chemotaxis (GO:0090023)3.62731981
30regulation of type I interferon-mediated signaling pathway (GO:0060338)3.62143485
31positive regulation of pseudopodium assembly (GO:0031274)3.58539626
32positive regulation of granulocyte chemotaxis (GO:0071624)3.55899423
33dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.54619420
34antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.45563162
35positive regulation of protein deacetylation (GO:0090312)3.44551149
36negative regulation of viral release from host cell (GO:1902187)3.41721317
37mannose metabolic process (GO:0006013)3.38571838
38myeloid dendritic cell differentiation (GO:0043011)3.38479487
39mitotic G1/S transition checkpoint (GO:0044819)3.36329098
40epithelial cell differentiation involved in prostate gland development (GO:0060742)3.25572505
41regulation of respiratory burst (GO:0060263)3.24309728
42peptidyl-tyrosine autophosphorylation (GO:0038083)3.19777592
43positive regulation of respiratory burst (GO:0060267)3.18953630
44thymic T cell selection (GO:0045061)3.18916237
45bundle of His cell to Purkinje myocyte communication (GO:0086069)3.16942166
46positive regulation of keratinocyte differentiation (GO:0045618)3.16802080
47regulation of Cdc42 GTPase activity (GO:0043088)3.15255679
48antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.14176308
49negative regulation of cell size (GO:0045792)3.11314078
50positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.09786662
51complement activation, classical pathway (GO:0006958)3.08629287
52regulation of pseudopodium assembly (GO:0031272)3.08321832
53detection of bacterium (GO:0016045)3.07185485
54interferon-gamma secretion (GO:0072643)3.05799961
55antigen processing and presentation of endogenous antigen (GO:0019883)3.05152928
56dendritic cell chemotaxis (GO:0002407)3.04631935
57regulation of MHC class I biosynthetic process (GO:0045343)3.04484407
58cellular response to exogenous dsRNA (GO:0071360)2.99682112
59response to type I interferon (GO:0034340)2.97647673
60positive regulation of odontogenesis (GO:0042482)2.97330554
61positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552)2.96422352
62cell volume homeostasis (GO:0006884)2.96295438
63head development (GO:0060322)2.95702014
64response to nitric oxide (GO:0071731)2.95507365
65myeloid dendritic cell activation (GO:0001773)2.95468483
66T-helper 1 type immune response (GO:0042088)2.95309439
67negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.93760767
68CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.93478822
69regulation of histone H3-K27 methylation (GO:0061085)2.91961091
70positive regulation of lipid kinase activity (GO:0090218)2.89189198
71intracellular estrogen receptor signaling pathway (GO:0030520)2.89035653
72atrioventricular valve morphogenesis (GO:0003181)2.87662726
73activation of JUN kinase activity (GO:0007257)2.84909510
74cellular response to virus (GO:0098586)2.84681035
75establishment of skin barrier (GO:0061436)2.84277336
76regulation of water loss via skin (GO:0033561)2.80895844
77CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.78021317
78T-helper cell differentiation (GO:0042093)2.78021317
79interferon-gamma-mediated signaling pathway (GO:0060333)2.73884959
80type I interferon signaling pathway (GO:0060337)2.73824080
81cellular response to type I interferon (GO:0071357)2.73824080
82phospholipid dephosphorylation (GO:0046839)2.72837361
83regulation of protein deacetylation (GO:0090311)2.70974258
84modulation by symbiont of host cellular process (GO:0044068)2.69974965
85regulation of phosphatidylinositol 3-kinase activity (GO:0043551)2.69430498
86positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.69413092
87modulation by virus of host process (GO:0019054)2.68461803
88stress granule assembly (GO:0034063)2.63139464
89regulation of viral release from host cell (GO:1902186)2.62989631
90detection of other organism (GO:0098543)2.62688941
91intestinal epithelial cell development (GO:0060576)2.62531207
92phosphatidylinositol dephosphorylation (GO:0046856)2.61105582
93vitamin transmembrane transport (GO:0035461)2.58037876
94positive regulation of glycoprotein biosynthetic process (GO:0010560)2.54014068
95establishment of planar polarity (GO:0001736)2.53183285
96establishment of tissue polarity (GO:0007164)2.53183285
97positive regulation of T-helper cell differentiation (GO:0045624)2.52835092
98positive regulation of mitochondrial membrane permeability (GO:0035794)2.49563189
99peptide catabolic process (GO:0043171)2.48850817
100branching involved in mammary gland duct morphogenesis (GO:0060444)2.47570898

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human3.45120761
2* LXR_22292898_ChIP-Seq_THP-1_Human3.13507752
3ESR2_21235772_ChIP-Seq_MCF-7_Human2.79450080
4STAT6_21828071_ChIP-Seq_BEAS2B_Human2.76379878
5RACK7_27058665_Chip-Seq_MCF-7_Human2.75456074
6* TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.72642356
7VDR_21846776_ChIP-Seq_THP-1_Human2.68717209
8KDM2B_26808549_Chip-Seq_SUP-B15_Human2.60452554
9ESR1_20079471_ChIP-ChIP_T-47D_Human2.55353287
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.53481341
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.47186218
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.43076152
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.39291035
14KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.23611252
15SMC4_20622854_ChIP-Seq_HELA_Human2.15185268
16P68_20966046_ChIP-Seq_HELA_Human2.13895413
17TCF7_22412390_ChIP-Seq_EML_Mouse2.11801520
18ERG_21242973_ChIP-ChIP_JURKAT_Human2.11010923
19* RUNX1_27514584_Chip-Seq_MCF-7_Human2.10863643
20TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.08108027
21ELK3_25401928_ChIP-Seq_HUVEC_Human1.98859898
22DROSHA_22980978_ChIP-Seq_HELA_Human1.95843592
23KDM2B_26808549_Chip-Seq_DND41_Human1.95300254
24ESR1_21235772_ChIP-Seq_MCF-7_Human1.91245038
25TP63_17297297_ChIP-ChIP_HaCaT_Human1.86298561
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.83075736
27CREB1_26743006_Chip-Seq_LNCaP_Human1.81856960
28BCOR_27268052_Chip-Seq_Bcells_Human1.79490806
29* SA1_27219007_Chip-Seq_ERYTHROID_Human1.71543731
30KDM2B_26808549_Chip-Seq_K562_Human1.70377041
31CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.69926212
32CTCF_27219007_Chip-Seq_ERYTHROID_Human1.69520504
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.65513533
34CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.60937895
35EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.60020668
36ZNF263_19887448_ChIP-Seq_K562_Human1.58657362
37ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.58565202
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.54921017
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.54560676
40GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.53786860
41SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.53512577
42RARG_19884340_ChIP-ChIP_MEFs_Mouse1.53387005
43DNAJC2_21179169_ChIP-ChIP_NT2_Human1.52801909
44KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.52201018
45ZFP281_18757296_ChIP-ChIP_E14_Mouse1.51355981
46SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.51337890
47E2F1_20622854_ChIP-Seq_HELA_Human1.49331006
48BCL6_27268052_Chip-Seq_Bcells_Human1.49119967
49MAF_26560356_Chip-Seq_TH2_Human1.48590660
50RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.48382245
51CTCF_27219007_Chip-Seq_Bcells_Human1.48036770
52SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.47458018
53MAF_26560356_Chip-Seq_TH1_Human1.45669545
54TP63_22573176_ChIP-Seq_HFKS_Human1.45435411
55TET1_21451524_ChIP-Seq_MESCs_Mouse1.45169308
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.42337941
57UTX_26944678_Chip-Seq_JUKART_Human1.42267046
58PHF8_20622854_ChIP-Seq_HELA_Human1.39300316
59* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.34985851
60VDR_24763502_ChIP-Seq_THP-1_Human1.34059786
61NCOR1_26117541_ChIP-Seq_K562_Human1.31937011
62ESR1_15608294_ChIP-ChIP_MCF-7_Human1.31865516
63GATA1_19941826_ChIP-Seq_K562_Human1.30052674
64ZFP281_27345836_Chip-Seq_ESCs_Mouse1.29537328
65P63_26484246_Chip-Seq_KERATINOCYTES_Human1.28571189
66SA1_27219007_Chip-Seq_Bcells_Human1.28540741
67KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.28325126
68SOX2_27498859_Chip-Seq_STOMACH_Mouse1.27841028
69SRY_22984422_ChIP-ChIP_TESTIS_Rat1.27738199
70VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26990458
71MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.23923642
72RARB_24833708_ChIP-Seq_LIVER_Mouse1.23077571
73KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.19676400
74NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19324323
75IKZF1_21737484_ChIP-ChIP_HCT116_Human1.19278604
76KDM2B_26808549_Chip-Seq_JURKAT_Human1.18456587
77KLF5_25053715_ChIP-Seq_YYC3_Human1.15585652
78CIITA_25753668_ChIP-Seq_RAJI_Human1.14624336
79MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.12983752
80NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.12720000
81RUNX1_22412390_ChIP-Seq_EML_Mouse1.11961505
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11612049
83ELF1_20517297_ChIP-Seq_JURKAT_Human1.11577986
84KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10169988
85GATA6_25053715_ChIP-Seq_YYC3_Human1.09788729
86PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08834524
87STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08645433
88WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07783979
89CTCF_26484167_Chip-Seq_Bcells_Mouse1.07763414
90BP1_19119308_ChIP-ChIP_Hs578T_Human1.07491420
91TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.05747848
92OCT4_19829295_ChIP-Seq_ESCs_Human1.05218135
93SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04297823
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04252047
95CTCF_21964334_ChIP-Seq_BJAB-B_Human1.03774032
96ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02126914
97CTCF_21964334_Chip-Seq_Bcells_Human1.00579631
98TP53_22127205_ChIP-Seq_IMR90_Human1.00332631
99GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99642698
100CTCF_20526341_ChIP-Seq_ESCs_Human0.99144108

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001873_stomach_inflammation4.70717949
2MP0000685_abnormal_immune_system3.79306824
3MP0002138_abnormal_hepatobiliary_system3.63034499
4MP0002254_reproductive_system_inflammat3.59913013
5MP0010234_abnormal_vibrissa_follicle3.15043715
6MP0005671_abnormal_response_to2.86349168
7MP0004510_myositis2.71945473
8MP0002098_abnormal_vibrissa_morphology2.42838573
9MP0005409_darkened_coat_color2.41233334
10MP0004381_abnormal_hair_follicle2.40485237
11MP0003705_abnormal_hypodermis_morpholog2.35965674
12MP0003453_abnormal_keratinocyte_physiol2.31257825
13MP0005076_abnormal_cell_differentiation2.25283861
14MP0001790_abnormal_immune_system2.25134483
15MP0005387_immune_system_phenotype2.25134483
16MP0002277_abnormal_respiratory_mucosa2.24001081
17MP0003763_abnormal_thymus_physiology2.21919912
18MP0002796_impaired_skin_barrier2.16292758
19MP0000678_abnormal_parathyroid_gland2.09484795
20MP0004264_abnormal_extraembryonic_tissu1.94946099
21MP0000858_altered_metastatic_potential1.94572498
22MP0003183_abnormal_peptide_metabolism1.90183074
23MP0000566_synostosis1.88888205
24MP0010155_abnormal_intestine_physiology1.85214144
25MP0005310_abnormal_salivary_gland1.84041873
26MP0003283_abnormal_digestive_organ1.82998438
27MP0005451_abnormal_body_composition1.81434868
28MP0000377_abnormal_hair_follicle1.81015583
29MP0001835_abnormal_antigen_presentation1.79711216
30MP0003878_abnormal_ear_physiology1.75068924
31MP0005377_hearing/vestibular/ear_phenot1.75068924
32MP0001188_hyperpigmentation1.73172181
33MP0003136_yellow_coat_color1.65250957
34MP0001800_abnormal_humoral_immune1.58165319
35MP0000383_abnormal_hair_follicle1.49837034
36MP0002396_abnormal_hematopoietic_system1.47717206
37MP0005025_abnormal_response_to1.43303650
38MP0002095_abnormal_skin_pigmentation1.42953916
39MP0005501_abnormal_skin_physiology1.41377869
40MP0009278_abnormal_bone_marrow1.38875667
41MP0003045_fibrosis1.37439253
42MP0008260_abnormal_autophagy1.36875690
43MP0000537_abnormal_urethra_morphology1.34691796
44MP0004782_abnormal_surfactant_physiolog1.34463190
45MP0004947_skin_inflammation1.33923288
46MP0001216_abnormal_epidermal_layer1.32226028
47MP0010678_abnormal_skin_adnexa1.31657980
48MP0002249_abnormal_larynx_morphology1.29824298
49MP0004858_abnormal_nervous_system1.29125237
50MP0003879_abnormal_hair_cell1.27079969
51MP0003638_abnormal_response/metabolism_1.18166564
52MP0009840_abnormal_foam_cell1.15199175
53MP0001485_abnormal_pinna_reflex1.14511449
54MP0002009_preneoplasia1.14078493
55MP0009931_abnormal_skin_appearance1.12366786
56MP0008004_abnormal_stomach_pH1.12180767
57MP0009384_cardiac_valve_regurgitation1.10233120
58MP0009780_abnormal_chondrocyte_physiolo1.05964805
59MP0002452_abnormal_antigen_presenting1.04010145
60MP0001664_abnormal_digestion1.03877363
61MP0009333_abnormal_splenocyte_physiolog1.02406763
62MP0003866_abnormal_defecation1.01534775
63MP0001849_ear_inflammation1.00685077
64MP0000367_abnormal_coat/_hair0.97397160
65MP0003303_peritoneal_inflammation0.95665687
66MP0000467_abnormal_esophagus_morphology0.94945965
67MP0000462_abnormal_digestive_system0.94610508
68MP0003436_decreased_susceptibility_to0.94277547
69MP0002723_abnormal_immune_serum0.93364074
70MP0001346_abnormal_lacrimal_gland0.91425732
71MP0005381_digestive/alimentary_phenotyp0.89703040
72MP0000470_abnormal_stomach_morphology0.88704835
73MP0004019_abnormal_vitamin_homeostasis0.87642943
74MP0002166_altered_tumor_susceptibility0.87047633
75MP0001663_abnormal_digestive_system0.86572103
76MP0005666_abnormal_adipose_tissue0.83071509
77MP0001270_distended_abdomen0.82980391
78MP0003091_abnormal_cell_migration0.81361674
79MP0000465_gastrointestinal_hemorrhage0.79671537
80MP0000613_abnormal_salivary_gland0.79428997
81MP0001819_abnormal_immune_cell0.79369996
82MP0002148_abnormal_hypersensitivity_rea0.79238076
83MP0000716_abnormal_immune_system0.78607399
84MP0005000_abnormal_immune_tolerance0.78009311
85MP0005360_urolithiasis0.77383480
86MP0003724_increased_susceptibility_to0.76624421
87MP0009643_abnormal_urine_homeostasis0.76342833
88MP0010352_gastrointestinal_tract_polyps0.75762277
89MP0002420_abnormal_adaptive_immunity0.75152791
90MP0002822_catalepsy0.74871380
91MP0009379_abnormal_foot_pigmentation0.72271266
92MP0001348_abnormal_lacrimal_gland0.72131141
93MP0002136_abnormal_kidney_physiology0.71975531
94MP0000750_abnormal_muscle_regeneration0.71954944
95MP0003941_abnormal_skin_development0.71915910
96MP0003172_abnormal_lysosome_physiology0.69612539
97MP0002735_abnormal_chemical_nociception0.69147757
98MP0002398_abnormal_bone_marrow0.68938813
99MP0000490_abnormal_crypts_of0.68088769
100MP0001845_abnormal_inflammatory_respons0.67306624

Predicted human phenotypes

RankGene SetZ-score
1Thin bony cortex (HP:0002753)5.42218502
2Malnutrition (HP:0004395)4.66482922
3Increased IgE level (HP:0003212)4.58066779
4Colitis (HP:0002583)4.54074490
5Lip pit (HP:0100267)3.99659339
6Agammaglobulinemia (HP:0004432)3.93445390
7Villous atrophy (HP:0011473)3.84723062
8Abnormality of small intestinal villus morphology (HP:0011472)3.84723062
9Obstructive sleep apnea (HP:0002870)3.72908476
10Sparse lateral eyebrow (HP:0005338)3.68103762
11Interstitial pulmonary disease (HP:0006530)3.54992794
12Right ventricular cardiomyopathy (HP:0011663)3.14744252
13Panhypogammaglobulinemia (HP:0003139)3.09066301
14Gastrointestinal inflammation (HP:0004386)3.08897572
15Abnormality of glutamine family amino acid metabolism (HP:0010902)2.95917103
16Gastrointestinal stroma tumor (HP:0100723)2.90684964
17Inflammation of the large intestine (HP:0002037)2.89566487
18Emphysema (HP:0002097)2.82301509
19Recurrent cutaneous fungal infections (HP:0011370)2.80807184
20Chronic mucocutaneous candidiasis (HP:0002728)2.80807184
21Nasal polyposis (HP:0100582)2.79344930
22Dysmetric saccades (HP:0000641)2.79159957
23Hyperacusis (HP:0010780)2.74435810
24Abnormality of the nasal mucosa (HP:0000433)2.64361445
25Abnormal delayed hypersensitivity skin test (HP:0002963)2.59225193
26J-shaped sella turcica (HP:0002680)2.58910644
27Abnormality of the fingertips (HP:0001211)2.56223636
28Seborrheic dermatitis (HP:0001051)2.46219191
29Concave nail (HP:0001598)2.46206008
30Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.43682137
31Broad face (HP:0000283)2.37094797
32Enlarged epiphyses (HP:0010580)2.36555485
33Hydroxyprolinuria (HP:0003080)2.36205726
34Abnormality of proline metabolism (HP:0010907)2.36205726
35Abnormality of the thoracic spine (HP:0100711)2.35443133
36Increased neuronal autofluorescent lipopigment (HP:0002074)2.33166508
37Broad nasal tip (HP:0000455)2.31396471
38Premature loss of primary teeth (HP:0006323)2.30524524
39Viral hepatitis (HP:0006562)2.29346969
40Polygenic inheritance (HP:0010982)2.25762676
41Delayed epiphyseal ossification (HP:0002663)2.24462600
42Flat acetabular roof (HP:0003180)2.22708285
43Abnormal vertebral ossification (HP:0100569)2.18739381
44Ridged nail (HP:0001807)2.15335436
45Pustule (HP:0200039)2.13556795
46Segmental peripheral demyelination/remyelination (HP:0003481)2.12283696
47Ileus (HP:0002595)2.11307551
48Recurrent fungal infections (HP:0002841)2.10396388
49Thoracic kyphosis (HP:0002942)2.10242599
50Increased cerebral lipofuscin (HP:0011813)2.09418649
51Recurrent viral infections (HP:0004429)2.07743520
52Abnormality of the salivary glands (HP:0010286)2.07655749
53Deformed sella turcica (HP:0002681)2.06286471
54Neoplasm of the heart (HP:0100544)2.04574318
55Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.03381296
56Absent hand (HP:0004050)2.03229762
57Ankyloglossia (HP:0010296)2.01345844
58Bone pain (HP:0002653)2.00669933
59Hemorrhage of the eye (HP:0011885)1.99172723
60Germ cell neoplasia (HP:0100728)1.98994877
61Elevated alkaline phosphatase (HP:0003155)1.97032725
62Ependymoma (HP:0002888)1.94455364
63Down-sloping shoulders (HP:0200021)1.92251051
64Milia (HP:0001056)1.91612030
65Abnormal hair laboratory examination (HP:0003328)1.91431351
66Spinal cord compression (HP:0002176)1.91383354
67Long eyelashes (HP:0000527)1.89525688
68Lymphangioma (HP:0100764)1.88486622
69Abnormality of nail color (HP:0100643)1.88324765
70Chronic otitis media (HP:0000389)1.88263156
71Eczematoid dermatitis (HP:0000976)1.87087189
72Distal lower limb muscle weakness (HP:0009053)1.86444551
73Severe Myopia (HP:0011003)1.85258468
74Widely patent fontanelles and sutures (HP:0004492)1.85125954
75Aplasia of the musculature (HP:0100854)1.84982199
76Squamous cell carcinoma (HP:0002860)1.84750200
77Neuronal loss in central nervous system (HP:0002529)1.83316115
78Popliteal pterygium (HP:0009756)1.82304646
79Neoplasm of the lung (HP:0100526)1.82277727
80Global brain atrophy (HP:0002283)1.81982516
81Hyperactive renin-angiotensin system (HP:0000841)1.79111664
82Abnormality of the gastric mucosa (HP:0004295)1.77898371
83Restrictive lung disease (HP:0002091)1.76167812
84Exostoses (HP:0100777)1.75192156
85Urethral obstruction (HP:0000796)1.75167915
86Cheilitis (HP:0100825)1.74482792
87Atelectasis (HP:0100750)1.69196352
88Acute lymphatic leukemia (HP:0006721)1.69068383
89Progressive external ophthalmoplegia (HP:0000590)1.68151350
90Abnormality of alkaline phosphatase activity (HP:0004379)1.67469144
91Flat occiput (HP:0005469)1.64790990
92Hypophosphatemia (HP:0002148)1.63683325
93Spinal muscular atrophy (HP:0007269)1.63680387
94Recurrent bronchitis (HP:0002837)1.63656680
95Woolly hair (HP:0002224)1.61722895
96Akinesia (HP:0002304)1.60241334
97Ankle clonus (HP:0011448)1.60054725
98Stomach cancer (HP:0012126)1.59607405
99High anterior hairline (HP:0009890)1.58773897
100Persistence of primary teeth (HP:0006335)1.58516349

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.79888077
2MST1R4.27194279
3SMG13.88940072
4CDK122.84244077
5RIPK12.73808221
6FGFR42.71270109
7EEF2K2.61949974
8SIK12.57159904
9MATK2.33019943
10MAP3K142.32342436
11MAP3K102.22969633
12EPHA32.15932093
13TYK22.03155625
14PKN22.02109898
15NME12.01239867
16EPHA21.73307769
17TAOK11.67988099
18ERN11.65231051
19RIPK41.59544971
20CHUK1.58395223
21IKBKE1.48541003
22SIK21.47209686
23MAP4K11.46851144
24MAP3K91.44743620
25MET1.44537132
26MAP3K131.42954104
27MAPK151.41156526
28BLK1.39888033
29CDC42BPA1.34189401
30MAP3K71.30421862
31HIPK21.29128079
32TBK11.26588470
33PTK61.26172387
34FGFR31.20805092
35NME21.20669358
36INSRR1.20256666
37PRPF4B1.19332866
38JAK11.18084445
39MUSK1.09484801
40TAF11.04158427
41EPHB11.03892641
42MARK21.03887868
43SIK31.02974379
44ERBB21.02547832
45MTOR0.99062085
46MAPKAPK30.98374357
47TNK20.94737240
48ICK0.93684468
49IRAK10.92218520
50RET0.86605011
51RPS6KA20.83950088
52PRKD20.82389278
53VRK20.77678687
54LRRK20.75912421
55WNK40.74100872
56OXSR10.72250708
57MAP3K10.70133527
58IKBKB0.70073303
59RPS6KB20.70005461
60MAP3K60.69808623
61FER0.66887519
62NEK60.66244142
63PDK20.65074797
64CAMKK10.64944974
65MAP2K10.61644798
66PASK0.61453135
67MAPK120.61255860
68STK390.60276374
69BMX0.58329049
70PDGFRA0.57410998
71RPS6KL10.54445309
72RPS6KC10.54445309
73MAPK70.52496533
74PDPK10.51184167
75RPS6KA60.50151119
76CSF1R0.45030287
77MAP2K20.44731910
78GRK60.44629846
79MAP2K60.44243288
80JAK30.44155630
81CDK70.43393080
82KDR0.42488843
83IRAK20.38982199
84MAPKAPK50.38749591
85JAK20.37980766
86MAPK30.37035676
87KIT0.36885485
88MAPK110.36220006
89IRAK30.35808983
90MAPK80.34852831
91IRAK40.34433407
92CDK90.34320459
93MAPK40.33850179
94PRKD30.31890529
95PRKD10.30464745
96NEK20.30100014
97PRKAA10.28402142
98STK110.26569621
99NUAK10.26253712
100PTK20.25842038

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.38473513
2Asthma_Homo sapiens_hsa053102.43161370
3Notch signaling pathway_Homo sapiens_hsa043302.32143180
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.26396483
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.05322662
6Allograft rejection_Homo sapiens_hsa053302.04601544
7ABC transporters_Homo sapiens_hsa020101.96993679
8Autoimmune thyroid disease_Homo sapiens_hsa053201.96186767
9Fructose and mannose metabolism_Homo sapiens_hsa000511.85842775
10NF-kappa B signaling pathway_Homo sapiens_hsa040641.82415355
11B cell receptor signaling pathway_Homo sapiens_hsa046621.81218647
12Bladder cancer_Homo sapiens_hsa052191.78445701
13Acute myeloid leukemia_Homo sapiens_hsa052211.77687752
14Prolactin signaling pathway_Homo sapiens_hsa049171.75100797
15Toxoplasmosis_Homo sapiens_hsa051451.71629790
16Influenza A_Homo sapiens_hsa051641.69875242
17Graft-versus-host disease_Homo sapiens_hsa053321.69541225
18Hepatitis C_Homo sapiens_hsa051601.56983364
19Pancreatic cancer_Homo sapiens_hsa052121.46574966
20Primary immunodeficiency_Homo sapiens_hsa053401.46429093
21VEGF signaling pathway_Homo sapiens_hsa043701.45364218
22Type I diabetes mellitus_Homo sapiens_hsa049401.41853203
23Antigen processing and presentation_Homo sapiens_hsa046121.40343083
24Vitamin digestion and absorption_Homo sapiens_hsa049771.34746735
25Other glycan degradation_Homo sapiens_hsa005111.33641853
26Leishmaniasis_Homo sapiens_hsa051401.26375361
27Herpes simplex infection_Homo sapiens_hsa051681.25716376
28Staphylococcus aureus infection_Homo sapiens_hsa051501.25643926
29TNF signaling pathway_Homo sapiens_hsa046681.24002855
30Chronic myeloid leukemia_Homo sapiens_hsa052201.23533224
31Non-small cell lung cancer_Homo sapiens_hsa052231.22645602
32Inositol phosphate metabolism_Homo sapiens_hsa005621.22211770
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.22083010
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.20831425
35Endometrial cancer_Homo sapiens_hsa052131.17565548
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.16019310
37Central carbon metabolism in cancer_Homo sapiens_hsa052301.12783039
38Thyroid hormone signaling pathway_Homo sapiens_hsa049191.08989400
39Lysine degradation_Homo sapiens_hsa003101.08578288
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08050691
41Histidine metabolism_Homo sapiens_hsa003401.07764160
42Toll-like receptor signaling pathway_Homo sapiens_hsa046201.05381691
43mTOR signaling pathway_Homo sapiens_hsa041501.04281277
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.04240916
45Tuberculosis_Homo sapiens_hsa051520.99800098
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99312816
47Linoleic acid metabolism_Homo sapiens_hsa005910.99028468
48Measles_Homo sapiens_hsa051620.98681945
49Renal cell carcinoma_Homo sapiens_hsa052110.96771208
50Pentose phosphate pathway_Homo sapiens_hsa000300.95636844
51Insulin resistance_Homo sapiens_hsa049310.95253429
52Dorso-ventral axis formation_Homo sapiens_hsa043200.94863800
53Small cell lung cancer_Homo sapiens_hsa052220.94739965
54Neurotrophin signaling pathway_Homo sapiens_hsa047220.91917134
55Thyroid cancer_Homo sapiens_hsa052160.91870763
56Prostate cancer_Homo sapiens_hsa052150.91489423
57Choline metabolism in cancer_Homo sapiens_hsa052310.87464320
58Estrogen signaling pathway_Homo sapiens_hsa049150.87184332
59Hepatitis B_Homo sapiens_hsa051610.82191132
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.81938890
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81230816
62Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80418376
63HIF-1 signaling pathway_Homo sapiens_hsa040660.80083512
64Epstein-Barr virus infection_Homo sapiens_hsa051690.78584054
65Osteoclast differentiation_Homo sapiens_hsa043800.78122099
66Viral myocarditis_Homo sapiens_hsa054160.74839648
67Glycerophospholipid metabolism_Homo sapiens_hsa005640.74438175
68Chemokine signaling pathway_Homo sapiens_hsa040620.73217862
69GnRH signaling pathway_Homo sapiens_hsa049120.73153610
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70941347
71ErbB signaling pathway_Homo sapiens_hsa040120.69610111
72HTLV-I infection_Homo sapiens_hsa051660.66462259
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66107603
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.63577414
75T cell receptor signaling pathway_Homo sapiens_hsa046600.62059291
76MicroRNAs in cancer_Homo sapiens_hsa052060.61941434
77Glioma_Homo sapiens_hsa052140.59575024
78Arginine biosynthesis_Homo sapiens_hsa002200.59089573
79Ether lipid metabolism_Homo sapiens_hsa005650.57966768
80Insulin signaling pathway_Homo sapiens_hsa049100.57590191
81AMPK signaling pathway_Homo sapiens_hsa041520.57580150
82Protein digestion and absorption_Homo sapiens_hsa049740.55798242
83Sulfur relay system_Homo sapiens_hsa041220.55273033
84Hematopoietic cell lineage_Homo sapiens_hsa046400.54754299
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.54741364
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54577295
87Apoptosis_Homo sapiens_hsa042100.51789107
88Fat digestion and absorption_Homo sapiens_hsa049750.51652124
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50882353
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.50295512
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49161900
92Endocytosis_Homo sapiens_hsa041440.47921948
93Pancreatic secretion_Homo sapiens_hsa049720.46668499
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45667400
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44627486
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43532458
97Arachidonic acid metabolism_Homo sapiens_hsa005900.40343063
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.38275328
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36646204
100African trypanosomiasis_Homo sapiens_hsa051430.34802315

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