IL17RE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane protein that functions as the receptor for interleukin-17C. The encoded protein signals to downstream components of the mitogen activated protein kinase (MAPK) pathway. Activity of this protein is important in the immune response to bacterial pathogens. Alternatively spliced transcript variants have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)6.30979491
2ribosomal small subunit assembly (GO:0000028)6.28707787
3intestinal absorption (GO:0050892)5.35547897
4DNA deamination (GO:0045006)5.22220804
5angiotensin maturation (GO:0002003)4.66048528
6response to interferon-beta (GO:0035456)4.61903701
7regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.50242645
8regulation of cholesterol homeostasis (GO:2000188)4.45190584
9polyketide metabolic process (GO:0030638)4.36582696
10doxorubicin metabolic process (GO:0044598)4.36582696
11daunorubicin metabolic process (GO:0044597)4.36582696
12regulation of guanylate cyclase activity (GO:0031282)4.08672699
13phospholipid scrambling (GO:0017121)3.97999259
14sulfate transmembrane transport (GO:1902358)3.97962997
15establishment of skin barrier (GO:0061436)3.95746911
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.93745885
17epoxygenase P450 pathway (GO:0019373)3.90687796
18respiratory chain complex IV assembly (GO:0008535)3.86774624
19lymphoid progenitor cell differentiation (GO:0002320)3.80831629
20proteasome assembly (GO:0043248)3.78824119
21viral transcription (GO:0019083)3.77166934
22response to interferon-alpha (GO:0035455)3.72305470
23positive regulation of fatty acid beta-oxidation (GO:0032000)3.70480038
24multicellular organismal water homeostasis (GO:0050891)3.70456159
25regulation of water loss via skin (GO:0033561)3.68689585
26negative regulation of viral genome replication (GO:0045071)3.65611723
27regulation of bile acid biosynthetic process (GO:0070857)3.57210472
28cytochrome complex assembly (GO:0017004)3.54661406
29detection of bacterium (GO:0016045)3.53881899
30SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.52728370
31ethanol metabolic process (GO:0006067)3.52457666
32nucleotide transmembrane transport (GO:1901679)3.51571014
33translational termination (GO:0006415)3.51236359
34flavonoid metabolic process (GO:0009812)3.47239725
35calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.45630454
36purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.45444933
373-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.45444933
38definitive hemopoiesis (GO:0060216)3.43406366
39detection of other organism (GO:0098543)3.42932717
40fat-soluble vitamin biosynthetic process (GO:0042362)3.42672633
41facial nerve structural organization (GO:0021612)3.39822009
42protein targeting to ER (GO:0045047)3.39330616
43intestinal cholesterol absorption (GO:0030299)3.39203267
44cotranslational protein targeting to membrane (GO:0006613)3.39179371
45regulation of systemic arterial blood pressure by hormone (GO:0001990)3.35703671
46regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.35703671
47endocrine process (GO:0050886)3.35703671
48ethanol oxidation (GO:0006069)3.32921929
49ribosomal small subunit biogenesis (GO:0042274)3.30822673
50sulfate transport (GO:0008272)3.28224426
51platelet dense granule organization (GO:0060155)3.27127206
52protein localization to endoplasmic reticulum (GO:0070972)3.27092378
53very-low-density lipoprotein particle assembly (GO:0034379)3.25915340
54arginine metabolic process (GO:0006525)3.25450621
55renal system process involved in regulation of blood volume (GO:0001977)3.24854981
56vitamin transmembrane transport (GO:0035461)3.24481003
57diacylglycerol metabolic process (GO:0046339)3.23461124
58urate metabolic process (GO:0046415)3.21762534
59transepithelial transport (GO:0070633)3.20840870
60superoxide anion generation (GO:0042554)3.19556164
61maturation of SSU-rRNA (GO:0030490)3.17753312
62tRNA methylation (GO:0030488)3.17301326
63establishment of protein localization to endoplasmic reticulum (GO:0072599)3.16859552
64drug metabolic process (GO:0017144)3.15409525
65low-density lipoprotein particle remodeling (GO:0034374)3.14998992
66positive regulation of T cell mediated cytotoxicity (GO:0001916)3.11782799
67NADH metabolic process (GO:0006734)3.09972932
68drug catabolic process (GO:0042737)3.09654496
69hormone catabolic process (GO:0042447)3.08674294
70exogenous drug catabolic process (GO:0042738)3.08520186
71primary alcohol catabolic process (GO:0034310)3.07236825
72water homeostasis (GO:0030104)3.06986337
73regulation of triglyceride catabolic process (GO:0010896)3.04660063
74positive regulation of fatty acid oxidation (GO:0046321)3.04513448
75regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.04240502
76renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.03862328
77glutathione biosynthetic process (GO:0006750)3.03608183
78positive regulation of lipoprotein lipase activity (GO:0051006)3.02536169
79positive regulation of triglyceride lipase activity (GO:0061365)3.02536169
80bile acid and bile salt transport (GO:0015721)3.02517386
81positive regulation of guanylate cyclase activity (GO:0031284)3.02293907
82cellular glucuronidation (GO:0052695)3.01349985
83response to protozoan (GO:0001562)3.01107435
84glucuronate metabolic process (GO:0019585)3.01066900
85uronic acid metabolic process (GO:0006063)3.01066900
86protein-lipid complex remodeling (GO:0034368)2.99787443
87macromolecular complex remodeling (GO:0034367)2.99787443
88plasma lipoprotein particle remodeling (GO:0034369)2.99787443
89response to peptidoglycan (GO:0032494)2.99342738
90high-density lipoprotein particle remodeling (GO:0034375)2.98766049
91aminoglycoside antibiotic metabolic process (GO:0030647)2.97668342
92negative regulation of nitric oxide biosynthetic process (GO:0045019)2.97492664
93cellular response to type I interferon (GO:0071357)2.96107178
94type I interferon signaling pathway (GO:0060337)2.96107178
95triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.95954930
96response to type I interferon (GO:0034340)2.95380696
97mature B cell differentiation involved in immune response (GO:0002313)2.94414820
98regulation of systemic arterial blood pressure (GO:0003073)2.92923951
99CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.92142068
100regulation of apoptotic process involved in morphogenesis (GO:1902337)2.88476269
101cellular response to interferon-beta (GO:0035458)2.88226574
102translational elongation (GO:0006414)2.87981909
103negative regulation of erythrocyte differentiation (GO:0045647)2.87977260
104regulation of T-helper 1 cell differentiation (GO:0045625)2.87955936
105regulation of interleukin-8 secretion (GO:2000482)2.86435670
106transcytosis (GO:0045056)2.85623394
107hemidesmosome assembly (GO:0031581)2.85413683
108phosphatidylserine acyl-chain remodeling (GO:0036150)2.85290192
109signal peptide processing (GO:0006465)2.84937030
110defense response to protozoan (GO:0042832)2.84807214
111viral life cycle (GO:0019058)2.84130908
112nonribosomal peptide biosynthetic process (GO:0019184)2.84119521
113regulation of cholesterol metabolic process (GO:0090181)2.83433333
114auditory receptor cell differentiation (GO:0042491)2.83165501
115phosphate ion homeostasis (GO:0055062)2.83061758
116trivalent inorganic anion homeostasis (GO:0072506)2.83061758
117interferon-gamma secretion (GO:0072643)2.82381191
118sulfur compound transport (GO:0072348)2.81837361
119antigen processing and presentation via MHC class Ib (GO:0002475)2.81754260
120maintenance of gastrointestinal epithelium (GO:0030277)2.80667659
121renal absorption (GO:0070293)2.79408141
122glycerol metabolic process (GO:0006071)2.78065228
123protein import into peroxisome matrix (GO:0016558)2.77491965
124plasma lipoprotein particle assembly (GO:0034377)2.76132887
125cellular zinc ion homeostasis (GO:0006882)2.76020217
126amino sugar catabolic process (GO:0046348)2.75995219
127positive regulation of lipid catabolic process (GO:0050996)2.75856085
128toxin transport (GO:1901998)2.75594232
129reverse cholesterol transport (GO:0043691)2.73168607
130N-acetylneuraminate metabolic process (GO:0006054)2.72795107
131negative regulation of transcription by competitive promoter binding (GO:0010944)2.72610029
132lipoprotein metabolic process (GO:0042157)2.72138714
133cell differentiation involved in metanephros development (GO:0072202)2.72105400
134dendritic cell chemotaxis (GO:0002407)2.71634302
135lipoprotein transport (GO:0042953)2.69892961
136cholesterol homeostasis (GO:0042632)2.69498212
137mature B cell differentiation (GO:0002335)2.69303944
138plasma lipoprotein particle organization (GO:0071827)2.68506390
139phospholipid efflux (GO:0033700)2.68201225
140cellular response to pH (GO:0071467)2.68131604
141response to UV-B (GO:0010224)2.66970246
142fucosylation (GO:0036065)2.66570478
143phenol-containing compound catabolic process (GO:0019336)2.65695015
144virion attachment to host cell (GO:0019062)2.64971232
145adhesion of symbiont to host cell (GO:0044650)2.64971232
146negative regulation of protein oligomerization (GO:0032460)2.64933833
147regulation of triglyceride metabolic process (GO:0090207)2.64606634
148positive regulation of triglyceride metabolic process (GO:0090208)2.64052564
149drug transmembrane transport (GO:0006855)2.63948051
150sterol homeostasis (GO:0055092)2.63590722
151very long-chain fatty acid metabolic process (GO:0000038)2.62412379
152glomerular filtration (GO:0003094)2.61525194
153primary alcohol metabolic process (GO:0034308)2.61169398
154positive regulation of respiratory burst (GO:0060267)2.60340065
155regulation of cell proliferation involved in kidney development (GO:1901722)2.59574841
156myeloid dendritic cell activation (GO:0001773)2.58161476
157regulation of fatty acid beta-oxidation (GO:0031998)2.58108565
158L-fucose catabolic process (GO:0042355)2.56363621
159fucose catabolic process (GO:0019317)2.56363621
160L-fucose metabolic process (GO:0042354)2.56363621
161regulation of T cell mediated cytotoxicity (GO:0001914)2.56228349
162excretion (GO:0007588)2.56009517
163bundle of His cell to Purkinje myocyte communication (GO:0086069)2.53330286
164positive regulation of gamma-delta T cell activation (GO:0046645)2.52470045
165positive regulation of NF-kappaB import into nucleus (GO:0042346)2.51672554
166deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.50986589
167regulation of regulatory T cell differentiation (GO:0045589)2.48179042
168negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.48018315
169negative regulation of T-helper cell differentiation (GO:0045623)2.48018315
170positive regulation of T cell chemotaxis (GO:0010820)2.46950951
171regulation of T cell chemotaxis (GO:0010819)2.46950951
172nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.45113136
173ribosomal large subunit biogenesis (GO:0042273)2.44572993
174hepatocyte apoptotic process (GO:0097284)2.43611379
175cellular protein complex disassembly (GO:0043624)2.41615379
176mesonephros development (GO:0001823)2.39554756
177positive regulation of T cell migration (GO:2000406)2.38934084
178T cell lineage commitment (GO:0002360)2.38603652
179sphingoid metabolic process (GO:0046519)2.38271700
180energy homeostasis (GO:0097009)2.38074229
181dendritic cell migration (GO:0036336)2.37828260
182lipoxygenase pathway (GO:0019372)2.37695824
183positive regulation of antigen processing and presentation (GO:0002579)2.37419238
184GPI anchor biosynthetic process (GO:0006506)2.36418404
185regulation of chemokine secretion (GO:0090196)2.34965659
186detection of external biotic stimulus (GO:0098581)2.34955048
187one-carbon compound transport (GO:0019755)2.34879975
188endosome to melanosome transport (GO:0035646)2.34509900
189endosome to pigment granule transport (GO:0043485)2.34509900
190metallo-sulfur cluster assembly (GO:0031163)2.31234720
191iron-sulfur cluster assembly (GO:0016226)2.31234720
192positive regulation of defense response to virus by host (GO:0002230)2.29783143
193regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.29540597
194mesenchymal cell differentiation involved in renal system development (GO:2001012)2.28478841
195mesenchymal cell differentiation involved in kidney development (GO:0072161)2.28478841

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.40993109
2SCL_19346495_ChIP-Seq_HPC-7_Human3.83990670
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.82606663
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.65921537
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.53594305
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.44406467
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.31193369
8NOTCH1_21737748_ChIP-Seq_TLL_Human3.15389129
9LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.92098520
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.85410709
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.79164043
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.73140045
13PPARA_22158963_ChIP-Seq_LIVER_Mouse2.63087738
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.60026306
15FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.54384552
16CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.52374826
17RXR_22158963_ChIP-Seq_LIVER_Mouse2.50988279
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.46151106
19* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.45332519
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.45221721
21ESR2_21235772_ChIP-Seq_MCF-7_Human2.27807660
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.25695874
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.24418711
24* GATA4_25053715_ChIP-Seq_YYC3_Human2.24158747
25STAT4_19710469_ChIP-ChIP_TH1__Mouse2.22071583
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.17116059
27PCGF2_27294783_Chip-Seq_ESCs_Mouse2.17073312
28IRF8_21731497_ChIP-ChIP_J774_Mouse2.14392295
29TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.12940176
30LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.10731079
31FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.07173404
32FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.05559638
33SRF_21415370_ChIP-Seq_HL-1_Mouse2.01125567
34EGR1_23403033_ChIP-Seq_LIVER_Mouse2.00791605
35FLI1_27457419_Chip-Seq_LIVER_Mouse2.00574040
36GATA2_21666600_ChIP-Seq_HMVEC_Human1.98840241
37LXR_22158963_ChIP-Seq_LIVER_Mouse1.98344206
38SOX2_27498859_Chip-Seq_STOMACH_Mouse1.97770335
39GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.95717817
40* GATA6_25053715_ChIP-Seq_YYC3_Human1.94010396
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.90745708
42SPI1_23547873_ChIP-Seq_NB4_Human1.90448426
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.87776925
44ERG_20887958_ChIP-Seq_HPC-7_Mouse1.86787396
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.83609295
46CDX2_20551321_ChIP-Seq_CACO-2_Human1.80556066
47ESR1_20079471_ChIP-ChIP_T-47D_Human1.77490125
48CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.74601714
49SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.72822606
50NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.71791734
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.71543870
52CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.69024618
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.67807085
54MYB_21317192_ChIP-Seq_ERMYB_Mouse1.67444850
55TP63_19390658_ChIP-ChIP_HaCaT_Human1.62386115
56* LXR_22292898_ChIP-Seq_THP-1_Human1.61245055
57CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.59367705
58GABP_17652178_ChIP-ChIP_JURKAT_Human1.59142639
59STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.58991784
60JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.56974653
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56758990
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.55597142
63IRF8_27001747_Chip-Seq_BMDM_Mouse1.52981264
64DROSHA_22980978_ChIP-Seq_HELA_Human1.52297762
65KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.49875896
66* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.49356309
67PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.49292833
68RACK7_27058665_Chip-Seq_MCF-7_Human1.48084410
69IRF1_19129219_ChIP-ChIP_H3396_Human1.47922425
70RUNX1_27514584_Chip-Seq_MCF-7_Human1.46758389
71HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.46405213
72* FOXA2_19822575_ChIP-Seq_HepG2_Human1.45004390
73BCL6_27268052_Chip-Seq_Bcells_Human1.44238617
74ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.43920468
75TP63_22573176_ChIP-Seq_HFKS_Human1.41223858
76* E2F1_20622854_ChIP-Seq_HELA_Human1.41006629
77HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40063793
78GATA1_22025678_ChIP-Seq_K562_Human1.39469544
79VDR_23849224_ChIP-Seq_CD4+_Human1.38798604
80NFE2_27457419_Chip-Seq_LIVER_Mouse1.38314583
81ZNF263_19887448_ChIP-Seq_K562_Human1.38021715
82CTCF_27219007_Chip-Seq_Bcells_Human1.37793707
83FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37593481
84ESR1_21235772_ChIP-Seq_MCF-7_Human1.36684003
85SOX2_20726797_ChIP-Seq_SW620_Human1.36416853
86* P68_20966046_ChIP-Seq_HELA_Human1.36358432
87FOXO3_23340844_ChIP-Seq_DLD1_Human1.34943732
88* BCOR_27268052_Chip-Seq_Bcells_Human1.33384185
89KLF5_25053715_ChIP-Seq_YYC3_Human1.28422605
90SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26960522
91GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26616148
92* HNF4A_19822575_ChIP-Seq_HepG2_Human1.25921949
93SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.25541294
94SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24804234
95BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.24286000
96RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.22884419
97EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22782491
98RAD21_21589869_ChIP-Seq_MESCs_Mouse1.22535595
99RUNX_20019798_ChIP-Seq_JUKART_Human1.22290329
100AHR_22903824_ChIP-Seq_MCF-7_Human1.21981588
101MYB_26560356_Chip-Seq_TH2_Human1.21870429
102NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19456776
103TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19397398
104* SMC4_20622854_ChIP-Seq_HELA_Human1.17994321
105MYC_18555785_ChIP-Seq_MESCs_Mouse1.17664049
106RUNX1_22412390_ChIP-Seq_EML_Mouse1.17088187
107TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16914132
108BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16563082
109ELK1_19687146_ChIP-ChIP_HELA_Human1.16233413
110* GATA3_24758297_ChIP-Seq_MCF-7_Human1.16123008
111EST1_17652178_ChIP-ChIP_JURKAT_Human1.16064688
112* TET1_21451524_ChIP-Seq_MESCs_Mouse1.15730581
113FOXH1_21741376_ChIP-Seq_ESCs_Human1.15034100
114FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.14800557
115* RAC3_21632823_ChIP-Seq_H3396_Human1.14689719
116MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.13242145
117CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12722227
118DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12456259
119HIF1A_21447827_ChIP-Seq_MCF-7_Human1.12038255
120P53_21459846_ChIP-Seq_SAOS-2_Human1.11886919
121ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11027397
122* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.10224226
123FOXP3_21729870_ChIP-Seq_TREG_Human1.09944351
124AR_20517297_ChIP-Seq_VCAP_Human1.09919874
125SA1_27219007_Chip-Seq_Bcells_Human1.09246899
126PPAR_26484153_Chip-Seq_NCI-H1993_Human1.08702795
127ERA_21632823_ChIP-Seq_H3396_Human1.08504730
128ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07766652
129SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06494582
130PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05790829
131PHF8_20622854_ChIP-Seq_HELA_Human1.05501591
132VDR_24763502_ChIP-Seq_THP-1_Human1.05431310
133ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04755820
134VDR_22108803_ChIP-Seq_LS180_Human1.04689159
135AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.04195202
136EZH2_27294783_Chip-Seq_NPCs_Mouse1.04184730
137EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04069800
138THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03577177
139FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.02899815
140GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02856596
141FOXA1_25552417_ChIP-Seq_VCAP_Human1.02817355
142NANOG_20526341_ChIP-Seq_ESCs_Human1.02774237
143BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02535291
144TCF4_18268006_ChIP-ChIP_LS174T_Human1.02432030
145SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.02341388
146SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.02341388
147CTCF_20526341_ChIP-Seq_ESCs_Human1.02239548
148EGR1_19032775_ChIP-ChIP_M12_Human1.01517809
149MYB_26560356_Chip-Seq_TH1_Human1.00957163
150ERG_21242973_ChIP-ChIP_JURKAT_Human1.00454973
151CREB1_26743006_Chip-Seq_LNCaP_Human1.00075783
152RARB_24833708_ChIP-Seq_LIVER_Mouse0.99265678
153RXR_22108803_ChIP-Seq_LS180_Human0.98842687
154JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.98734001
155GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98622351
156CEBPB_22108803_ChIP-Seq_LS180_Human0.97526833
157SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.95968456
158* TAF2_19829295_ChIP-Seq_ESCs_Human0.95539185
159PU_27001747_Chip-Seq_BMDM_Mouse0.94722834
160Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.94554326
161ZNF274_21170338_ChIP-Seq_K562_Hela0.93758548
162* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.93069337
163TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.92996087
164PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92613671
165STAT1_17558387_ChIP-Seq_HELA_Human0.92352779
166SUZ12_18555785_Chip-Seq_ESCs_Mouse0.91473924
167KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91284956
168P300_27268052_Chip-Seq_Bcells_Human0.90913686
169YY1_22570637_ChIP-Seq_MALME-3M_Human0.90823989
170EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.90359537
171NMYC_18555785_Chip-Seq_ESCs_Mouse0.90215137
172STAT3_18555785_Chip-Seq_ESCs_Mouse0.89886562
173* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89724821
174SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89541984
175CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.89486569
176P53_22387025_ChIP-Seq_ESCs_Mouse0.89367049
177EZH2_27294783_Chip-Seq_ESCs_Mouse0.88939914
178CDX2_19796622_ChIP-Seq_MESCs_Mouse0.88732825
179* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88730110
180UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.88503661
181ELK1_22589737_ChIP-Seq_MCF10A_Human0.88348486
182HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.84846994
183ZFX_18555785_Chip-Seq_ESCs_Mouse0.84726787
184PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84298428
185* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82974865

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.00489360
2MP0010234_abnormal_vibrissa_follicle4.74958334
3MP0002139_abnormal_hepatobiliary_system3.62043955
4MP0006292_abnormal_olfactory_placode3.39693551
5MP0005365_abnormal_bile_salt3.37656495
6MP0009379_abnormal_foot_pigmentation3.13643100
7MP0001666_abnormal_nutrient_absorption3.12134260
8MP0005085_abnormal_gallbladder_physiolo3.07133986
9MP0004264_abnormal_extraembryonic_tissu3.00299043
10MP0005174_abnormal_tail_pigmentation2.85422783
11MP0010329_abnormal_lipoprotein_level2.77320207
12MP0001835_abnormal_antigen_presentation2.74095936
13MP0001188_hyperpigmentation2.66914107
14MP0004381_abnormal_hair_follicle2.58336378
15MP0005075_abnormal_melanosome_morpholog2.57699418
16MP0004043_abnormal_pH_regulation2.53923885
17MP0009785_altered_susceptibility_to2.50020003
18MP0005671_abnormal_response_to2.35602701
19MP0005670_abnormal_white_adipose2.34970070
20MP0004019_abnormal_vitamin_homeostasis2.26360567
21MP0002009_preneoplasia2.22297771
22MP0003724_increased_susceptibility_to2.21743330
23MP0002148_abnormal_hypersensitivity_rea2.21234097
24MP0004782_abnormal_surfactant_physiolog2.19335755
25MP0008875_abnormal_xenobiotic_pharmacok2.15199602
26MP0003136_yellow_coat_color2.11701261
27MP0003183_abnormal_peptide_metabolism2.11629258
28MP0009780_abnormal_chondrocyte_physiolo2.08086939
29MP0000490_abnormal_crypts_of2.03887910
30MP0000015_abnormal_ear_pigmentation1.97455415
31MP0002132_abnormal_respiratory_system1.95582344
32MP0009840_abnormal_foam_cell1.94804743
33MP0000681_abnormal_thyroid_gland1.93638999
34MP0000566_synostosis1.93097290
35MP0001765_abnormal_ion_homeostasis1.90351496
36MP0000685_abnormal_immune_system1.88902067
37MP0003941_abnormal_skin_development1.87294142
38MP0003763_abnormal_thymus_physiology1.83429469
39MP0002095_abnormal_skin_pigmentation1.78898152
40MP0005409_darkened_coat_color1.76563009
41MP0000372_irregular_coat_pigmentation1.76103926
42MP0005025_abnormal_response_to1.73619479
43MP0002396_abnormal_hematopoietic_system1.73185833
44MP0003252_abnormal_bile_duct1.72076962
45MP0003195_calcinosis1.67835560
46MP0002876_abnormal_thyroid_physiology1.66722788
47MP0002277_abnormal_respiratory_mucosa1.66528806
48MP0010155_abnormal_intestine_physiology1.64906195
49MP0009643_abnormal_urine_homeostasis1.64361985
50MP0001873_stomach_inflammation1.61918011
51MP0003191_abnormal_cellular_cholesterol1.61876931
52MP0002877_abnormal_melanocyte_morpholog1.60942537
53MP0002166_altered_tumor_susceptibility1.59250604
54MP0004808_abnormal_hematopoietic_stem1.59049449
55MP0005501_abnormal_skin_physiology1.58284867
56MP0003866_abnormal_defecation1.55853694
57MP0005275_abnormal_skin_tensile1.54869677
58MP0001986_abnormal_taste_sensitivity1.54135036
59MP0002006_tumorigenesis1.53111524
60MP0010678_abnormal_skin_adnexa1.51888305
61MP0002118_abnormal_lipid_homeostasis1.51097584
62MP0003436_decreased_susceptibility_to1.47847896
63MP0005000_abnormal_immune_tolerance1.47789558
64MP0002098_abnormal_vibrissa_morphology1.44945788
65MP0001919_abnormal_reproductive_system1.42033702
66MP0005332_abnormal_amino_acid1.41389941
67MP0000465_gastrointestinal_hemorrhage1.41040766
68MP0000427_abnormal_hair_cycle1.40722932
69MP0002452_abnormal_antigen_presenting1.39836979
70MP0002723_abnormal_immune_serum1.39073675
71MP0000383_abnormal_hair_follicle1.36852018
72MP0005636_abnormal_mineral_homeostasis1.36639972
73MP0002420_abnormal_adaptive_immunity1.35921196
74MP0001819_abnormal_immune_cell1.35198846
75MP0002138_abnormal_hepatobiliary_system1.35168442
76MP0008995_early_reproductive_senescence1.34956336
77MP0001800_abnormal_humoral_immune1.34935876
78MP0002419_abnormal_innate_immunity1.34138953
79MP0008004_abnormal_stomach_pH1.31746268
80MP0000678_abnormal_parathyroid_gland1.30491022
81MP0001790_abnormal_immune_system1.30154043
82MP0005387_immune_system_phenotype1.30154043
83MP0006082_CNS_inflammation1.28431791
84MP0005397_hematopoietic_system_phenotyp1.26429595
85MP0001545_abnormal_hematopoietic_system1.26429595
86MP0000467_abnormal_esophagus_morphology1.25857011
87MP0003868_abnormal_feces_composition1.24827263
88MP0005083_abnormal_biliary_tract1.23447440
89MP0005448_abnormal_energy_balance1.21642255
90MP0005310_abnormal_salivary_gland1.18832720
91MP0005367_renal/urinary_system_phenotyp1.17089812
92MP0000516_abnormal_urinary_system1.17089812
93MP0003786_premature_aging1.17054349
94MP0010386_abnormal_urinary_bladder1.16762576
95MP0005084_abnormal_gallbladder_morpholo1.16681443
96MP0000477_abnormal_intestine_morphology1.12788393
97MP0000613_abnormal_salivary_gland1.12770872
98MP0005464_abnormal_platelet_physiology1.10896291
99MP0003943_abnormal_hepatobiliary_system1.10220716
100MP0001346_abnormal_lacrimal_gland1.10170588
101MP0003315_abnormal_perineum_morphology1.09488911
102MP0005408_hypopigmentation1.09302070
103MP0002938_white_spotting1.05262240
104MP0002136_abnormal_kidney_physiology1.05055492
105MP0001845_abnormal_inflammatory_respons1.04731779
106MP0002398_abnormal_bone_marrow1.04345175
107MP0000579_abnormal_nail_morphology1.04112396
108MP0003186_abnormal_redox_activity1.03174202
109MP0002971_abnormal_brown_adipose1.02953538
110MP0009333_abnormal_splenocyte_physiolog1.02225889
111MP0000716_abnormal_immune_system1.02169981
112MP0001764_abnormal_homeostasis1.00979235
113MP0003879_abnormal_hair_cell1.00944741
114MP0000609_abnormal_liver_physiology1.00425028
115MP0000377_abnormal_hair_follicle0.99024975
116MP0009764_decreased_sensitivity_to0.98943240
117MP0001756_abnormal_urination0.98788723
118MP0005377_hearing/vestibular/ear_phenot0.98171028
119MP0003878_abnormal_ear_physiology0.98171028
120MP0002405_respiratory_system_inflammati0.98005075
121MP0005389_reproductive_system_phenotype0.96992389
122MP0002177_abnormal_outer_ear0.96971518
123MP0009697_abnormal_copulation0.96597078
124MP0010771_integument_phenotype0.96466143
125MP0003950_abnormal_plasma_membrane0.93669421
126MP0001663_abnormal_digestive_system0.93606362
127MP0002796_impaired_skin_barrier0.91947551
128MP0005171_absent_coat_pigmentation0.90652868
129MP0004147_increased_porphyrin_level0.89886951
130MP0000013_abnormal_adipose_tissue0.89250808
131MP0000538_abnormal_urinary_bladder0.88197009
132MP0001664_abnormal_digestion0.87976168
133MP0008007_abnormal_cellular_replicative0.86440934
134MP0000049_abnormal_middle_ear0.86276096
135MP0003693_abnormal_embryo_hatching0.86071033
136MP0000230_abnormal_systemic_arterial0.85924210
137MP0001853_heart_inflammation0.85513655
138MP0008058_abnormal_DNA_repair0.84996934
139MP0002254_reproductive_system_inflammat0.84618961
140MP0000689_abnormal_spleen_morphology0.84562814
141MP0001186_pigmentation_phenotype0.83663515
142MP0009384_cardiac_valve_regurgitation0.83280021
143MP0002429_abnormal_blood_cell0.83181548
144MP0002160_abnormal_reproductive_system0.81932200
145MP0008872_abnormal_physiological_respon0.81805324
146MP0003453_abnormal_keratinocyte_physiol0.81740899
147MP0003638_abnormal_response/metabolism_0.81570220
148MP0002722_abnormal_immune_system0.81037152
149MP0005381_digestive/alimentary_phenotyp0.80790999
150MP0001216_abnormal_epidermal_layer0.80429396
151MP0003828_pulmonary_edema0.80321759
152MP0002060_abnormal_skin_morphology0.79334033
153MP0004947_skin_inflammation0.77684001
154MP0000470_abnormal_stomach_morphology0.77467735
155MP0001348_abnormal_lacrimal_gland0.76233094
156MP0002970_abnormal_white_adipose0.71826355
157MP0005319_abnormal_enzyme/_coenzyme0.71452600
158MP0002249_abnormal_larynx_morphology0.71102544
159MP0001501_abnormal_sleep_pattern0.69304540
160MP0009115_abnormal_fat_cell0.68320840
161MP0005023_abnormal_wound_healing0.67132339
162MP0000462_abnormal_digestive_system0.66821760
163MP0000367_abnormal_coat/_hair0.66212666
164MP0003011_delayed_dark_adaptation0.65913211
165MP0002089_abnormal_postnatal_growth/wei0.65866182
166MP0009642_abnormal_blood_homeostasis0.63656993
167MP0002896_abnormal_bone_mineralization0.63447925
168MP0003705_abnormal_hypodermis_morpholog0.62159687
169MP0004858_abnormal_nervous_system0.61683217
170MP0003953_abnormal_hormone_level0.61238553
171MP0003045_fibrosis0.60824535

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glutamine family amino acid metabolism (HP:0010902)5.86525625
2Hydroxyprolinuria (HP:0003080)4.79682636
3Abnormality of proline metabolism (HP:0010907)4.79682636
4Right ventricular cardiomyopathy (HP:0011663)4.36257569
5Decreased circulating renin level (HP:0003351)4.13237713
6Nonprogressive disorder (HP:0003680)4.09190055
7Type I transferrin isoform profile (HP:0003642)3.86991000
8Malnutrition (HP:0004395)3.58961363
9Xanthomatosis (HP:0000991)3.50263154
10Abnormality of renin-angiotensin system (HP:0000847)3.44986055
11Alopecia of scalp (HP:0002293)3.41159274
12Reticulocytopenia (HP:0001896)3.35188378
13Flat acetabular roof (HP:0003180)3.35139034
14Type 2 muscle fiber atrophy (HP:0003554)3.32566333
15Abnormality of cells of the erythroid lineage (HP:0012130)3.23968879
16Reduced antithrombin III activity (HP:0001976)3.22224526
17Abnormal number of erythroid precursors (HP:0012131)3.19137326
18Widely patent fontanelles and sutures (HP:0004492)3.17573921
19Hemorrhage of the eye (HP:0011885)3.16161558
20Muscle fiber atrophy (HP:0100295)3.15808073
21Ileus (HP:0002595)3.05107181
22Potter facies (HP:0002009)3.03553202
23Facial shape deformation (HP:0011334)3.03553202
24Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.94392596
25Abnormal protein N-linked glycosylation (HP:0012347)2.94392596
26Abnormal protein glycosylation (HP:0012346)2.94392596
27Abnormal glycosylation (HP:0012345)2.94392596
28Abnormality of the vitamin B12 metabolism (HP:0004341)2.92674097
29Aplastic anemia (HP:0001915)2.92316334
30Hypotrichosis (HP:0001006)2.91984534
31Onycholysis (HP:0001806)2.90020315
32Hyperglycinuria (HP:0003108)2.89087915
33Pigmentary retinal degeneration (HP:0001146)2.88962730
34Abnormality of monocarboxylic acid metabolism (HP:0010996)2.86681837
35Metabolic alkalosis (HP:0200114)2.85657893
36Woolly hair (HP:0002224)2.85394468
37Chronic diarrhea (HP:0002028)2.84663397
38IgM deficiency (HP:0002850)2.81546957
39Myositis (HP:0100614)2.80053411
40Abnormality of vitamin B metabolism (HP:0004340)2.79775955
41Hypothermia (HP:0002045)2.79748976
42Elevated erythrocyte sedimentation rate (HP:0003565)2.79283618
43Pustule (HP:0200039)2.78519172
44Alkalosis (HP:0001948)2.72704448
45Patchy hypopigmentation of hair (HP:0011365)2.65894834
46Plantar hyperkeratosis (HP:0007556)2.63799455
47Petechiae (HP:0000967)2.60827558
48Fat malabsorption (HP:0002630)2.58130195
49Prolonged bleeding time (HP:0003010)2.55643143
50Deep venous thrombosis (HP:0002625)2.54790958
51Abnormality of vitamin metabolism (HP:0100508)2.54359637
52Palmoplantar hyperkeratosis (HP:0000972)2.53967154
53Aplasia/Hypoplasia of the sacrum (HP:0008517)2.53509145
54Systemic lupus erythematosus (HP:0002725)2.53426946
55Sparse eyelashes (HP:0000653)2.49606380
56Aplasia/hypoplasia of the uterus (HP:0008684)2.48122774
57Pili torti (HP:0003777)2.46622961
5811 pairs of ribs (HP:0000878)2.45903140
59Retrobulbar optic neuritis (HP:0100654)2.45387765
60Optic neuritis (HP:0100653)2.45387765
613-Methylglutaconic aciduria (HP:0003535)2.44849954
62Abnormality of secondary sexual hair (HP:0009888)2.44450167
63Abnormality of the axillary hair (HP:0100134)2.44450167
64Thrombocytosis (HP:0001894)2.43427578
65Orchitis (HP:0100796)2.38127894
66True hermaphroditism (HP:0010459)2.37966394
67Cheilitis (HP:0100825)2.36963190
68Abnormality of serine family amino acid metabolism (HP:0010894)2.36788430
69Abnormality of glycine metabolism (HP:0010895)2.36788430
70Thin bony cortex (HP:0002753)2.35054626
71Hyperactive renin-angiotensin system (HP:0000841)2.31563685
72Palmar hyperkeratosis (HP:0010765)2.27839950
73Recurrent abscess formation (HP:0002722)2.27667186
74Epidermoid cyst (HP:0200040)2.25374884
75Hypobetalipoproteinemia (HP:0003563)2.25097113
76Abdominal distention (HP:0003270)2.24620468
77Lip pit (HP:0100267)2.23493667
78Abnormality of nail color (HP:0100643)2.21896813
79Cerebral palsy (HP:0100021)2.21845784
80Amelogenesis imperfecta (HP:0000705)2.19575066
81Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.19568772
82Clubbing of toes (HP:0100760)2.18913332
83Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.17533614
84Decreased activity of mitochondrial respiratory chain (HP:0008972)2.17533614
85Complement deficiency (HP:0004431)2.17023384
86Vacuolated lymphocytes (HP:0001922)2.16462355
87Pallor (HP:0000980)2.15481160
88Unilateral renal agenesis (HP:0000122)2.15453557
89Conjugated hyperbilirubinemia (HP:0002908)2.14457201
90White forelock (HP:0002211)2.13583437
91Brushfield spots (HP:0001088)2.13271254
92Congenital sensorineural hearing impairment (HP:0008527)2.12761043
93Mucopolysacchariduria (HP:0008155)2.12154814
94Urinary glycosaminoglycan excretion (HP:0003541)2.12154814
95Absent rod-and cone-mediated responses on ERG (HP:0007688)2.10785481
96Milia (HP:0001056)2.10224989
97Abnormality of polysaccharide metabolism (HP:0011012)2.09403684
98Abnormality of glycosaminoglycan metabolism (HP:0004371)2.09403684
99Abnormality of mucopolysaccharide metabolism (HP:0011020)2.09403684
100Abnormality of the costochondral junction (HP:0000919)2.08549860
101Hyperaldosteronism (HP:0000859)2.07907933
102Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.07579068
103Flat occiput (HP:0005469)2.05654031
104Dry hair (HP:0011359)2.05242974
105Acanthosis nigricans (HP:0000956)2.05030447
106Tubular atrophy (HP:0000092)2.04618411
107Delayed CNS myelination (HP:0002188)2.03679167
108Confusion (HP:0001289)2.03540876
109Weak cry (HP:0001612)2.03349740
110Hypoplasia of the uterus (HP:0000013)2.02909392
111Pendular nystagmus (HP:0012043)2.02262034
112Renal cortical cysts (HP:0000803)2.02234048
113Wide cranial sutures (HP:0010537)2.01888475
114Generalized aminoaciduria (HP:0002909)1.99384371
115Mediastinal lymphadenopathy (HP:0100721)1.98145153
116Glycosuria (HP:0003076)1.96672484
117Abnormality of urine glucose concentration (HP:0011016)1.96672484
118Hyperphosphatemia (HP:0002905)1.96123109
119Vascular calcification (HP:0004934)1.95820004
120Abnormality of renal resorption (HP:0011038)1.94653506
121Glomerulonephritis (HP:0000099)1.94086840
122Hypergonadotropic hypogonadism (HP:0000815)1.93023872
123Congenital, generalized hypertrichosis (HP:0004540)1.92846906
124Meningitis (HP:0001287)1.92305951
125Abnormality of chloride homeostasis (HP:0011422)1.92036602
126Abnormality of calcium-phosphate metabolism (HP:0100530)1.91968738
127Renal Fanconi syndrome (HP:0001994)1.91327759
128Flat capital femoral epiphysis (HP:0003370)1.90430085
129Erythema (HP:0010783)1.89662681
130Eczematoid dermatitis (HP:0000976)1.88775330
131Interstitial pulmonary disease (HP:0006530)1.88759556
132Focal segmental glomerulosclerosis (HP:0000097)1.88536830
133Abnormal tarsal ossification (HP:0008369)1.87976868
134Pancreatic cysts (HP:0001737)1.87577079
135Conical tooth (HP:0000698)1.86616463
136Abnormality of the gastric mucosa (HP:0004295)1.86429854
137Delayed epiphyseal ossification (HP:0002663)1.85539623
138Abnormality of the nasal septum (HP:0000419)1.85149351
139Stridor (HP:0010307)1.84997889
140Severe visual impairment (HP:0001141)1.84389935
141Abnormal blistering of the skin (HP:0008066)1.84350847
142Thyroid-stimulating hormone excess (HP:0002925)1.83903536
143Abnormality of carpal bone ossification (HP:0006257)1.83679033
144Renal tubular dysfunction (HP:0000124)1.83406138
145Abnormality of complement system (HP:0005339)1.83294426
146Glomerulosclerosis (HP:0000096)1.82925762
147Chromosomal breakage induced by crosslinking agents (HP:0003221)1.82588663
148Abnormality of magnesium homeostasis (HP:0004921)1.82484126
149Abnormality of macrophages (HP:0004311)1.81559906
150Nephritis (HP:0000123)1.80794287
151Abnormality of dicarboxylic acid metabolism (HP:0010995)1.80683546
152Dicarboxylic aciduria (HP:0003215)1.80683546
153Chronic otitis media (HP:0000389)1.80240475
154Aplasia/hypoplasia of the femur (HP:0005613)1.80222538
155Hyperkalemia (HP:0002153)1.79798571
156Concave nail (HP:0001598)1.78498235
157Renal tubular acidosis (HP:0001947)1.78456703
158Lymphangioma (HP:0100764)1.77808260
159Protuberant abdomen (HP:0001538)1.76875331
160Nephrolithiasis (HP:0000787)1.76525426
161Exertional dyspnea (HP:0002875)1.74611460
162Corneal erosion (HP:0200020)1.74448040
163Enlarged epiphyses (HP:0010580)1.73626412
164Hypoplasia of dental enamel (HP:0006297)1.73392386
165Abnormality of the neuromuscular junction (HP:0003398)1.72263297
166Fatigable weakness (HP:0003473)1.72263297
167Abnormality of the renal cortex (HP:0011035)1.72032441
168Pancreatic fibrosis (HP:0100732)1.71206629
169Anhidrosis (HP:0000970)1.70862330
170Macrocytic anemia (HP:0001972)1.70387342
171Hypoproteinemia (HP:0003075)1.70220604
172Abnormality of the preputium (HP:0100587)1.70105388
173Microretrognathia (HP:0000308)1.69871999
174Microcytic anemia (HP:0001935)1.69356054
175Alveolar cell carcinoma (HP:0006519)1.68568829
176Chromsome breakage (HP:0040012)1.68340491
177Recurrent bacterial skin infections (HP:0005406)1.66762168
178Prostate neoplasm (HP:0100787)1.65650072
179Fragile nails (HP:0001808)1.65210824
180Median cleft lip (HP:0000161)1.65089457
181Recurrent cutaneous fungal infections (HP:0011370)1.64874209
182Chronic mucocutaneous candidiasis (HP:0002728)1.64874209
183Abnormal hair laboratory examination (HP:0003328)1.64615461
184Chronic sinusitis (HP:0011109)1.64008191
185Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.63065413
186Hypoplasia of the fovea (HP:0007750)1.61917814
187Aplasia/Hypoplasia of the fovea (HP:0008060)1.61917814
188Pulmonary artery stenosis (HP:0004415)1.60809651
189Pancytopenia (HP:0001876)1.60270320
190Hepatic necrosis (HP:0002605)1.59409172

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK4.64884814
2IRAK33.76804585
3NME23.10508647
4MET2.86496895
5SRPK12.83531542
6RIPK12.60857061
7TXK2.52577501
8WNK42.46912918
9SIK12.45321711
10ERN12.38376533
11IRAK42.28481762
12STK162.24156419
13TEC2.19235578
14CASK2.13171766
15LMTK22.12991515
16FRK2.11360906
17FGFR42.07520321
18EPHA21.99906867
19TNIK1.99815725
20FER1.97964517
21TRIB31.86243712
22MAP3K141.84890122
23MAP3K121.83174993
24IKBKE1.78671085
25KIT1.71177371
26PIM21.69474692
27NLK1.68570222
28MKNK21.61905734
29MST41.58480129
30ZAK1.58110201
31YES11.51801844
32BTK1.46182326
33STK391.43601145
34FLT31.43216686
35IKBKB1.42550199
36MAP4K21.39689570
37PRKAA21.38372405
38MYLK1.37356961
39MKNK11.36318533
40PKN21.34895728
41MAP4K11.34547505
42ADRBK21.33131497
43LATS11.31338217
44EEF2K1.30442842
45EPHB21.29282510
46MAP2K61.27550348
47GRK61.22728787
48TIE11.20582277
49RPS6KB21.19258196
50TBK11.18486608
51PTK61.17984082
52NUAK11.17126487
53STK241.14607863
54PRKG21.13294561
55TGFBR21.11871132
56MATK1.11799694
57IRAK11.11166144
58ZAP701.09471790
59BMPR1B1.08944978
60GRK11.07574548
61FGFR31.06357010
62EIF2AK21.06057986
63ACVR1B1.02023342
64CAMKK21.01203265
65CDC42BPA1.00514935
66OXSR11.00475297
67MAP3K60.99275706
68PRKCI0.97659507
69BLK0.96723944
70DDR20.96679001
71JAK30.96340474
72VRK10.94095710
73MAP3K70.93316810
74PIM10.92687421
75MAP3K20.91607569
76CHUK0.91595192
77ERBB20.91579314
78PLK40.88555301
79EIF2AK30.85965778
80NEK90.85271233
81TNK20.85063908
82CAMKK10.84010748
83AKT30.83569796
84MAPK150.81876458
85MAP3K30.81714571
86TRPM70.80666982
87TYK20.78926372
88TAOK30.78841613
89ICK0.78707427
90RPS6KA40.77377457
91NME10.76566690
92ITK0.76334625
93RIPK40.75508669
94MAPKAPK50.75264908
95TLK10.74148063
96CAMK10.73936111
97MAPKAPK30.73872225
98TGFBR10.73412831
99SYK0.72541679
100PTK20.71905083
101STK38L0.71884563
102MAP3K130.71662261
103BMPR20.71208038
104NEK60.71077052
105MAP2K30.70706983
106HIPK20.68156852
107MAPK110.67503541
108PIK3CG0.67321743
109CDK30.66734561
110LYN0.65624113
111DAPK20.64490873
112PDPK10.64393626
113STK380.63866265
114MAP2K20.62415026
115EPHA30.62280620
116EPHB10.61652614
117FGFR20.60777401
118PASK0.59328330
119FGFR10.58995496
120PINK10.57928159
121SGK20.57781328
122MST1R0.57344039
123PRKD20.57205678
124CLK10.56014225
125SIK30.55604467
126RPS6KA60.55534370
127PIK3CA0.53796900
128IRAK20.53319321
129ERBB30.51321787
130TESK20.51048922
131FES0.50975471
132PRKAA10.49283170
133BCR0.49239125
134CSNK1A10.48769610
135MAPK70.47231889
136CSF1R0.46973585
137RPS6KC10.45754964
138RPS6KL10.45754964
139DYRK1B0.45303599
140LCK0.44616571
141CDK190.44370633
142INSRR0.44135995
143TESK10.43090001
144IGF1R0.42397681
145RPS6KA20.42059349
146BCKDK0.41978327
147ADRBK10.41379995
148SRC0.40991529
149KDR0.40896814
150RPS6KA50.40504489
151MAP3K110.40280884
152CDK90.39851493
153CSNK1G10.39294254
154PRKCZ0.38802794
155PRKCE0.38288799
156PRKCA0.37894613
157PDK10.36537345
158TAOK10.35719899
159CSK0.35104186
160MAPKAPK20.34721048
161SIK20.30050521
162PRKACG0.28640304

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004604.59689359
2Ribosome_Homo sapiens_hsa030103.97249541
3Fat digestion and absorption_Homo sapiens_hsa049753.47357621
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.80394019
5Histidine metabolism_Homo sapiens_hsa003402.71592803
6Protein export_Homo sapiens_hsa030602.64281706
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.51439583
8Renin-angiotensin system_Homo sapiens_hsa046142.40484124
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.27903781
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.01432885
11PPAR signaling pathway_Homo sapiens_hsa033201.95769070
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.95425973
13Fatty acid degradation_Homo sapiens_hsa000711.85899743
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.85137202
15Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.84969273
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.83588528
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.77505541
18Other glycan degradation_Homo sapiens_hsa005111.77375668
19Glycerolipid metabolism_Homo sapiens_hsa005611.77046951
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.72804054
21SNARE interactions in vesicular transport_Homo sapiens_hsa041301.70475433
22Homologous recombination_Homo sapiens_hsa034401.69831551
23Arginine biosynthesis_Homo sapiens_hsa002201.66650083
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.64044895
25Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.63476471
26Hematopoietic cell lineage_Homo sapiens_hsa046401.62753729
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.60603243
28Nitrogen metabolism_Homo sapiens_hsa009101.60007677
29Primary immunodeficiency_Homo sapiens_hsa053401.55068735
30DNA replication_Homo sapiens_hsa030301.53958580
31RNA polymerase_Homo sapiens_hsa030201.53557618
32ABC transporters_Homo sapiens_hsa020101.53148571
33Protein digestion and absorption_Homo sapiens_hsa049741.52883587
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.51989227
35Bile secretion_Homo sapiens_hsa049761.50916317
36Starch and sucrose metabolism_Homo sapiens_hsa005001.50852445
37Pyrimidine metabolism_Homo sapiens_hsa002401.48099557
38Phenylalanine metabolism_Homo sapiens_hsa003601.46953284
39Allograft rejection_Homo sapiens_hsa053301.46206029
40Arachidonic acid metabolism_Homo sapiens_hsa005901.46197639
41Measles_Homo sapiens_hsa051621.45520988
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.42865686
43Tryptophan metabolism_Homo sapiens_hsa003801.40972945
44Herpes simplex infection_Homo sapiens_hsa051681.39379819
45Base excision repair_Homo sapiens_hsa034101.39101162
46Fanconi anemia pathway_Homo sapiens_hsa034601.38870713
47Fructose and mannose metabolism_Homo sapiens_hsa000511.37045608
48Leishmaniasis_Homo sapiens_hsa051401.35610879
49Drug metabolism - other enzymes_Homo sapiens_hsa009831.35403887
50Jak-STAT signaling pathway_Homo sapiens_hsa046301.32829823
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.32255118
52Toll-like receptor signaling pathway_Homo sapiens_hsa046201.31345768
53Proteasome_Homo sapiens_hsa030501.31036696
54Autoimmune thyroid disease_Homo sapiens_hsa053201.29961871
55Folate biosynthesis_Homo sapiens_hsa007901.28917349
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.28699995
57Sulfur relay system_Homo sapiens_hsa041221.28690503
58Sphingolipid metabolism_Homo sapiens_hsa006001.26984966
59Fatty acid metabolism_Homo sapiens_hsa012121.26583751
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.24522441
61N-Glycan biosynthesis_Homo sapiens_hsa005101.22923469
62Ether lipid metabolism_Homo sapiens_hsa005651.22014801
63Fatty acid biosynthesis_Homo sapiens_hsa000611.21674635
64Tyrosine metabolism_Homo sapiens_hsa003501.20006135
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.17810192
66Basal transcription factors_Homo sapiens_hsa030221.17105362
67Peroxisome_Homo sapiens_hsa041461.17028555
68Pentose and glucuronate interconversions_Homo sapiens_hsa000401.15368605
69Transcriptional misregulation in cancer_Homo sapiens_hsa052021.14634089
70Arginine and proline metabolism_Homo sapiens_hsa003301.12447849
71Complement and coagulation cascades_Homo sapiens_hsa046101.11983309
72Legionellosis_Homo sapiens_hsa051341.09933401
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07551429
74Butanoate metabolism_Homo sapiens_hsa006501.06785867
75Purine metabolism_Homo sapiens_hsa002301.03294737
76Rheumatoid arthritis_Homo sapiens_hsa053231.02164801
77Graft-versus-host disease_Homo sapiens_hsa053320.94391700
78Influenza A_Homo sapiens_hsa051640.92349599
79RNA degradation_Homo sapiens_hsa030180.92002472
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91261467
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90909900
82Mismatch repair_Homo sapiens_hsa034300.90434781
83Acute myeloid leukemia_Homo sapiens_hsa052210.88797746
84Pertussis_Homo sapiens_hsa051330.85489586
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.85274540
86TNF signaling pathway_Homo sapiens_hsa046680.84948011
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.84636443
88Asthma_Homo sapiens_hsa053100.81675512
89Spliceosome_Homo sapiens_hsa030400.79868939
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79812178
91Malaria_Homo sapiens_hsa051440.79231268
92Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76128666
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75920150
94Nucleotide excision repair_Homo sapiens_hsa034200.74230652
95Non-homologous end-joining_Homo sapiens_hsa034500.73700240
96Vitamin digestion and absorption_Homo sapiens_hsa049770.73099102
97Glutathione metabolism_Homo sapiens_hsa004800.71044092
98Hepatitis C_Homo sapiens_hsa051600.70661007
99Caffeine metabolism_Homo sapiens_hsa002320.69729258
100Toxoplasmosis_Homo sapiens_hsa051450.68603787
101Insulin resistance_Homo sapiens_hsa049310.66903201
102Sulfur metabolism_Homo sapiens_hsa009200.66582773
103Antigen processing and presentation_Homo sapiens_hsa046120.63324907
104Oxidative phosphorylation_Homo sapiens_hsa001900.63007992
1052-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.62789787
106Osteoclast differentiation_Homo sapiens_hsa043800.62524168
107Retinol metabolism_Homo sapiens_hsa008300.62218665
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.61892961
109Thyroid cancer_Homo sapiens_hsa052160.61350971
110Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60500459
111Chemical carcinogenesis_Homo sapiens_hsa052040.60472640
112Apoptosis_Homo sapiens_hsa042100.59559559
113beta-Alanine metabolism_Homo sapiens_hsa004100.58890046
114Circadian rhythm_Homo sapiens_hsa047100.58700583
115Pancreatic secretion_Homo sapiens_hsa049720.58469881
116Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57789628
117Galactose metabolism_Homo sapiens_hsa000520.55180005
118Regulation of autophagy_Homo sapiens_hsa041400.54531315
119p53 signaling pathway_Homo sapiens_hsa041150.54493753
120Tuberculosis_Homo sapiens_hsa051520.54056700
121Salmonella infection_Homo sapiens_hsa051320.53713752
122Hepatitis B_Homo sapiens_hsa051610.53517406
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53470148
124Fatty acid elongation_Homo sapiens_hsa000620.51618026
125Ovarian steroidogenesis_Homo sapiens_hsa049130.50308868
126Leukocyte transendothelial migration_Homo sapiens_hsa046700.49746997
127Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49432599
128B cell receptor signaling pathway_Homo sapiens_hsa046620.48160521
129Renin secretion_Homo sapiens_hsa049240.47841850
130Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.46740556
131Shigellosis_Homo sapiens_hsa051310.45916848
132Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45876989
133Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45799521
134Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45618859
135Prolactin signaling pathway_Homo sapiens_hsa049170.45124627
136Glycosaminoglycan degradation_Homo sapiens_hsa005310.42274845
137Staphylococcus aureus infection_Homo sapiens_hsa051500.42266471
138Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.42060045
139Tight junction_Homo sapiens_hsa045300.41456198
140Thyroid hormone synthesis_Homo sapiens_hsa049180.41203481
141Linoleic acid metabolism_Homo sapiens_hsa005910.40200810
142Type I diabetes mellitus_Homo sapiens_hsa049400.36655141
143Phototransduction_Homo sapiens_hsa047440.36383292
144Mineral absorption_Homo sapiens_hsa049780.36342848
145Platelet activation_Homo sapiens_hsa046110.36306601
146Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34948139
147Collecting duct acid secretion_Homo sapiens_hsa049660.34739799
148AMPK signaling pathway_Homo sapiens_hsa041520.34297066
149Selenocompound metabolism_Homo sapiens_hsa004500.33432570
150Pyruvate metabolism_Homo sapiens_hsa006200.33038087
151Metabolic pathways_Homo sapiens_hsa011000.32847794
152Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.30475608
153Insulin secretion_Homo sapiens_hsa049110.29351194
154ECM-receptor interaction_Homo sapiens_hsa045120.29109743
155Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.26313120
156Taste transduction_Homo sapiens_hsa047420.25441469
157Propanoate metabolism_Homo sapiens_hsa006400.24610797
158Lysosome_Homo sapiens_hsa041420.24533924
159Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.24112304
160Glucagon signaling pathway_Homo sapiens_hsa049220.23615247
161Vascular smooth muscle contraction_Homo sapiens_hsa042700.21899400
162Lysine degradation_Homo sapiens_hsa003100.18579308
163Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.16352975
164Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.15029588
165Dorso-ventral axis formation_Homo sapiens_hsa043200.14284891

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