IL17RC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.04467699
2L-phenylalanine metabolic process (GO:0006558)5.04467699
3sulfur amino acid catabolic process (GO:0000098)5.03668954
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.03017686
5L-phenylalanine catabolic process (GO:0006559)5.03017686
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.99884080
7aromatic amino acid family catabolic process (GO:0009074)4.47627497
8homocysteine metabolic process (GO:0050667)4.34329695
9bile acid and bile salt transport (GO:0015721)4.28166034
10regulation of triglyceride catabolic process (GO:0010896)4.24375105
11alpha-linolenic acid metabolic process (GO:0036109)4.21147586
12urea cycle (GO:0000050)4.20820521
13urea metabolic process (GO:0019627)4.20820521
14cysteine metabolic process (GO:0006534)4.18655908
15kynurenine metabolic process (GO:0070189)4.16580183
16intestinal cholesterol absorption (GO:0030299)4.14715605
17high-density lipoprotein particle remodeling (GO:0034375)4.14399296
18negative regulation of fibrinolysis (GO:0051918)4.13701988
19protein carboxylation (GO:0018214)4.09509800
20peptidyl-glutamic acid carboxylation (GO:0017187)4.09509800
21indole-containing compound catabolic process (GO:0042436)4.06264902
22indolalkylamine catabolic process (GO:0046218)4.06264902
23tryptophan catabolic process (GO:0006569)4.06264902
24phospholipid efflux (GO:0033700)4.05178283
25regulation of cholesterol homeostasis (GO:2000188)4.03805679
26bile acid biosynthetic process (GO:0006699)3.85339109
27regulation of fibrinolysis (GO:0051917)3.84865367
28nitrogen cycle metabolic process (GO:0071941)3.83767579
29negative regulation of cholesterol transport (GO:0032375)3.83673554
30negative regulation of sterol transport (GO:0032372)3.83673554
31regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.82318410
32desmosome organization (GO:0002934)3.81335313
33tryptophan metabolic process (GO:0006568)3.78818888
34glyoxylate metabolic process (GO:0046487)3.78528465
35regulation of cholesterol esterification (GO:0010872)3.76090737
36cellular ketone body metabolic process (GO:0046950)3.75714878
37triglyceride homeostasis (GO:0070328)3.71738813
38acylglycerol homeostasis (GO:0055090)3.71738813
39regulation of protein activation cascade (GO:2000257)3.71667982
40complement activation, alternative pathway (GO:0006957)3.71395445
41intestinal absorption (GO:0050892)3.68278653
42fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.67403577
43reverse cholesterol transport (GO:0043691)3.67098723
44bile acid metabolic process (GO:0008206)3.66464994
45protein-lipid complex remodeling (GO:0034368)3.65138988
46macromolecular complex remodeling (GO:0034367)3.65138988
47plasma lipoprotein particle remodeling (GO:0034369)3.65138988
48plasma lipoprotein particle clearance (GO:0034381)3.62762371
49amino-acid betaine metabolic process (GO:0006577)3.62473501
50lysine catabolic process (GO:0006554)3.60631267
51lysine metabolic process (GO:0006553)3.60631267
52regulation of complement activation (GO:0030449)3.53480022
53drug catabolic process (GO:0042737)3.50636835
54cellular glucuronidation (GO:0052695)3.47504500
55bundle of His cell to Purkinje myocyte communication (GO:0086069)3.43211842
56flavonoid metabolic process (GO:0009812)3.42924730
57positive regulation of triglyceride lipase activity (GO:0061365)3.40470515
58positive regulation of lipoprotein lipase activity (GO:0051006)3.40470515
59hemidesmosome assembly (GO:0031581)3.39935478
60fibrinolysis (GO:0042730)3.39569869
61regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.38795003
62serine family amino acid catabolic process (GO:0009071)3.38505683
63endothelial cell chemotaxis (GO:0035767)3.34474037
64regulation of bile acid biosynthetic process (GO:0070857)3.34199879
65ketone body metabolic process (GO:1902224)3.32178736
66positive regulation of lipid catabolic process (GO:0050996)3.31626092
67aromatic amino acid family metabolic process (GO:0009072)3.30289027
68epoxygenase P450 pathway (GO:0019373)3.30244996
69lipoprotein metabolic process (GO:0042157)3.30072089
70positive regulation of fatty acid beta-oxidation (GO:0032000)3.28727531
71COPI coating of Golgi vesicle (GO:0048205)3.26640425
72Golgi transport vesicle coating (GO:0048200)3.26640425
73cholesterol homeostasis (GO:0042632)3.26474476
74cellular modified amino acid catabolic process (GO:0042219)3.25245165
75basement membrane organization (GO:0071711)3.23961162
76sterol homeostasis (GO:0055092)3.22956358
77positive regulation of triglyceride metabolic process (GO:0090208)3.18398306
78ethanol oxidation (GO:0006069)3.17663786
79plasma lipoprotein particle assembly (GO:0034377)3.16492371
80cholesterol efflux (GO:0033344)3.15086159
81fatty acid oxidation (GO:0019395)3.14941240
82negative regulation of fatty acid transport (GO:2000192)3.13361477
83fatty acid beta-oxidation (GO:0006635)3.13242380
84alpha-amino acid catabolic process (GO:1901606)3.13173226
85tyrosine metabolic process (GO:0006570)3.11428948
86regulation of cholesterol biosynthetic process (GO:0045540)3.10316735
87low-density lipoprotein particle clearance (GO:0034383)3.09195588
88ethanol metabolic process (GO:0006067)3.08564828
89uronic acid metabolic process (GO:0006063)3.07391224
90glucuronate metabolic process (GO:0019585)3.07391224
91lipid oxidation (GO:0034440)3.07389380
92valine metabolic process (GO:0006573)3.07327607
93negative regulation of lipase activity (GO:0060192)3.06727436
94cellular amino acid catabolic process (GO:0009063)3.05984034
95positive regulation of fatty acid oxidation (GO:0046321)3.02906543
96protein retention in ER lumen (GO:0006621)3.02151976
97protein-lipid complex assembly (GO:0065005)3.01811428
98primary alcohol catabolic process (GO:0034310)3.00193279
99adhesion of symbiont to host (GO:0044406)2.99697044
100phospholipid homeostasis (GO:0055091)2.98461173
101benzene-containing compound metabolic process (GO:0042537)2.97110066
102carnitine metabolic process (GO:0009437)2.96428684
103drug metabolic process (GO:0017144)2.95638408
104negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.93432050
105vascular endothelial growth factor signaling pathway (GO:0038084)2.93240376
106regulation of cholesterol metabolic process (GO:0090181)2.92764895
107regulation of plasminogen activation (GO:0010755)2.92713621
108NADH metabolic process (GO:0006734)2.92181102
109very-low-density lipoprotein particle assembly (GO:0034379)2.92026986
110omega-hydroxylase P450 pathway (GO:0097267)2.91887667
111fatty acid catabolic process (GO:0009062)2.91194921
112regulation of fatty acid beta-oxidation (GO:0031998)2.89499045
113positive regulation of fatty acid biosynthetic process (GO:0045723)2.89281643
114GDP-mannose metabolic process (GO:0019673)2.88869104
115drug transmembrane transport (GO:0006855)2.88410546
116virion attachment to host cell (GO:0019062)2.84362108
117adhesion of symbiont to host cell (GO:0044650)2.84362108
118negative regulation of cell size (GO:0045792)2.83007143
119epithelial cell-cell adhesion (GO:0090136)2.80493702
120semaphorin-plexin signaling pathway (GO:0071526)2.80363485
121proline biosynthetic process (GO:0006561)2.76650306
122glutathione biosynthetic process (GO:0006750)2.76320394
123maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.75783752
124proline metabolic process (GO:0006560)2.71975946
125exogenous drug catabolic process (GO:0042738)2.71136352
126barbed-end actin filament capping (GO:0051016)2.68189991
127type B pancreatic cell proliferation (GO:0044342)2.65841460
128retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.62617809
129multicellular organismal water homeostasis (GO:0050891)2.60653890
130regulation of glucose import in response to insulin stimulus (GO:2001273)2.58724508
131nonribosomal peptide biosynthetic process (GO:0019184)2.55821112
132cell-cell junction maintenance (GO:0045217)2.52728102
1334-hydroxyproline metabolic process (GO:0019471)2.51541260
134planar cell polarity pathway involved in neural tube closure (GO:0090179)2.48692507
135regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.47879752
136UV protection (GO:0009650)2.46487932
137positive regulation of cellular amine metabolic process (GO:0033240)2.45247334
138amyloid precursor protein catabolic process (GO:0042987)2.45143213
139mannose metabolic process (GO:0006013)2.42757307
140skin morphogenesis (GO:0043589)2.42587085
141regulation of fatty acid biosynthetic process (GO:0042304)2.42372539
142positive regulation of fatty acid metabolic process (GO:0045923)2.42139279
143negative regulation of lipid transport (GO:0032369)2.39952884
144regulation of water loss via skin (GO:0033561)2.39305322
145cell-substrate junction assembly (GO:0007044)2.38708607
146regulation of apoptotic cell clearance (GO:2000425)2.37298557
147macroautophagy (GO:0016236)2.37223911
148biotin metabolic process (GO:0006768)2.36918969
149regulation of extracellular matrix disassembly (GO:0010715)2.33803486
150protein heterotrimerization (GO:0070208)2.33185161
151negative regulation of blood coagulation (GO:0030195)2.31380881
152negative regulation of hemostasis (GO:1900047)2.31380881
153opsonization (GO:0008228)2.30784109
154cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.30322275
155negative regulation of fatty acid biosynthetic process (GO:0045717)2.29424142
156cell volume homeostasis (GO:0006884)2.27262123
157glutamine family amino acid biosynthetic process (GO:0009084)2.26714268
158fat-soluble vitamin biosynthetic process (GO:0042362)2.24265139
159cell-substrate adherens junction assembly (GO:0007045)2.23635662

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.54225067
2TP63_17297297_ChIP-ChIP_HaCaT_Human7.45942320
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.40358380
4RXR_22158963_ChIP-Seq_LIVER_Mouse5.39519968
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.94842188
6LXR_22158963_ChIP-Seq_LIVER_Mouse4.25710795
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.73946976
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.18955248
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.18161055
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.93749846
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.87866637
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.66417565
13CLOCK_20551151_ChIP-Seq_293T_Human2.59466052
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.45363501
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.43708892
16ERG_21242973_ChIP-ChIP_JURKAT_Human1.99942882
17PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.99086095
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.98027863
19ESR2_21235772_ChIP-Seq_MCF-7_Human1.89616661
20ESR1_21235772_ChIP-Seq_MCF-7_Human1.89291290
21ZNF263_19887448_ChIP-Seq_K562_Human1.87275893
22CDX2_20551321_ChIP-Seq_CACO-2_Human1.85284828
23SOX2_27498859_Chip-Seq_STOMACH_Mouse1.85028138
24VDR_21846776_ChIP-Seq_THP-1_Human1.83445765
25TET1_21451524_ChIP-Seq_MESCs_Mouse1.77116868
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.73613208
27* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.71566531
28SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.68958608
29CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.68081479
30GATA4_25053715_ChIP-Seq_YYC3_Human1.63708358
31* P68_20966046_ChIP-Seq_HELA_Human1.62902035
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.62880322
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.62437403
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61372080
35SOX2_20726797_ChIP-Seq_SW620_Human1.57183278
36CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.56700233
37SA1_27219007_Chip-Seq_ERYTHROID_Human1.51497606
38* SMC4_20622854_ChIP-Seq_HELA_Human1.50611774
39* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.50326683
40* CTCF_27219007_Chip-Seq_Bcells_Human1.47594181
41RACK7_27058665_Chip-Seq_MCF-7_Human1.47309512
42KDM2B_26808549_Chip-Seq_K562_Human1.45331876
43P63_26484246_Chip-Seq_KERATINOCYTES_Human1.44933721
44FOXO3_23340844_ChIP-Seq_DLD1_Human1.44622656
45EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.42221423
46DNAJC2_21179169_ChIP-ChIP_NT2_Human1.41706867
47PPAR_26484153_Chip-Seq_NCI-H1993_Human1.40065751
48CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.39936364
49CTCF_27219007_Chip-Seq_ERYTHROID_Human1.37743481
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.36775728
51ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.36116966
52GATA6_25053715_ChIP-Seq_YYC3_Human1.34990718
53TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.33654873
54SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.31968946
55* KDM2B_26808549_Chip-Seq_DND41_Human1.29916500
56KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29209080
57* ATF3_27146783_Chip-Seq_COLON_Human1.28050881
58LXR_22292898_ChIP-Seq_THP-1_Human1.25789963
59* TP53_22127205_ChIP-Seq_IMR90_Human1.24647467
60BCL6_27268052_Chip-Seq_Bcells_Human1.22723244
61ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22328937
62* BCOR_27268052_Chip-Seq_Bcells_Human1.20951238
63KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20542338
64NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.19649986
65ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19368018
66RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.19108549
67ELF1_20517297_ChIP-Seq_JURKAT_Human1.19071663
68* FOXA2_19822575_ChIP-Seq_HepG2_Human1.17494505
69* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.17178264
70TCF7_22412390_ChIP-Seq_EML_Mouse1.17137342
71SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.15600911
72SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.15600911
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14302684
74STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12740647
75KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11828418
76HIF1A_21447827_ChIP-Seq_MCF-7_Human1.11262955
77ESR1_20079471_ChIP-ChIP_T-47D_Human1.11204683
78SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11170915
79ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10326719
80WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09888201
81* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.09860258
82STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09165975
83CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08890894
84TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08442805
85NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08428588
86RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07743027
87* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.06279738
88ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.05193578
89* RARB_24833708_ChIP-Seq_LIVER_Mouse1.04900157
90* TET1_21490601_ChIP-Seq_MESCs_Mouse1.04406051
91HNF4A_19822575_ChIP-Seq_HepG2_Human1.02668427
92UBF1/2_26484160_Chip-Seq_HMECs_Human1.02640612
93SA1_27219007_Chip-Seq_Bcells_Human0.99718133
94* E2F1_20622854_ChIP-Seq_HELA_Human0.99043164
95* ELK3_25401928_ChIP-Seq_HUVEC_Human0.98493589
96GATA3_24758297_ChIP-Seq_MCF-7_Human0.97539993
97SMC1_22415368_ChIP-Seq_MEFs_Mouse0.96969327
98MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.96303988
99CTCF_20526341_ChIP-Seq_ESCs_Human0.95619275
100PHF8_20622854_ChIP-Seq_HELA_Human0.95451745
101* RUNX1_27514584_Chip-Seq_MCF-7_Human0.94732106
102PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.94563374
103FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.94479172
104SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.94289776
105TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.94286667
106JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.93652096
107* CTCF_26484167_Chip-Seq_Bcells_Mouse0.93068732
108CJUN_26792858_Chip-Seq_BT549_Human0.92791182
109CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.91408300
110ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91120263
111STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90205743
112SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89422389
113UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.89098374
114BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87051951
115AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.86719540
116CDX2_19796622_ChIP-Seq_MESCs_Mouse0.83205298
117JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83075106
118P300_27058665_Chip-Seq_ZR-75-30cells_Human0.81806481
119NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.81589623
120NRF2_20460467_ChIP-Seq_MEFs_Mouse0.81589623
121GATA1_22025678_ChIP-Seq_K562_Human0.81431294
122TP63_22573176_ChIP-Seq_HFKS_Human0.81414876
123TBX20_22080862_ChIP-Seq_HEART_Mouse0.80721894
124TBX20_22328084_ChIP-Seq_HEART_Mouse0.80721894
125BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.80655243
126KLF5_25053715_ChIP-Seq_YYC3_Human0.78673915
127ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.77826996
128* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.77807928
129CREB1_26743006_Chip-Seq_LNCaP_Human0.77755672
130GATA2_21666600_ChIP-Seq_HMVEC_Human0.76853945
131NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.76352019
132CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.74732228
133ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.74009503
134RXRA_24833708_ChIP-Seq_LIVER_Mouse0.72542569
135PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.72320531
136FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.72269550
137JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71642922
138TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.71627956
139TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.70907204
140NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.70609627
141RAD21_21589869_ChIP-Seq_MESCs_Mouse0.70460602
142SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.70307940
143ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.67108156
144SRY_22984422_ChIP-ChIP_TESTIS_Rat0.66902630

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.70500867
2MP0002139_abnormal_hepatobiliary_system5.56939541
3MP0005085_abnormal_gallbladder_physiolo4.38812094
4MP0005365_abnormal_bile_salt4.14877463
5MP0003705_abnormal_hypodermis_morpholog3.94018646
6MP0008875_abnormal_xenobiotic_pharmacok3.39411293
7MP0005275_abnormal_skin_tensile3.13247598
8MP0003252_abnormal_bile_duct3.02033558
9MP0005058_abnormal_lysosome_morphology2.98525047
10MP0001666_abnormal_nutrient_absorption2.92483671
11MP0008438_abnormal_cutaneous_collagen2.74635098
12MP0002796_impaired_skin_barrier2.68558880
13MP0010329_abnormal_lipoprotein_level2.63677438
14MP0009840_abnormal_foam_cell2.63116800
15MP0010234_abnormal_vibrissa_follicle2.57739405
16MP0000751_myopathy2.44007858
17MP0003806_abnormal_nucleotide_metabolis2.39136584
18MP0003191_abnormal_cellular_cholesterol2.28922922
19MP0004858_abnormal_nervous_system2.28484750
20MP0005083_abnormal_biliary_tract2.27191263
21MP0002060_abnormal_skin_morphology2.07854822
22MP0002254_reproductive_system_inflammat1.98763216
23MP0005332_abnormal_amino_acid1.90653469
24MP0004019_abnormal_vitamin_homeostasis1.81320547
25MP0005409_darkened_coat_color1.77916793
26MP0009384_cardiac_valve_regurgitation1.58656382
27MP0002118_abnormal_lipid_homeostasis1.57937169
28MP0005501_abnormal_skin_physiology1.57913524
29MP0003195_calcinosis1.55728384
30MP0000609_abnormal_liver_physiology1.50809282
31MP0000579_abnormal_nail_morphology1.44994998
32MP0009780_abnormal_chondrocyte_physiolo1.38929329
33MP0003453_abnormal_keratinocyte_physiol1.36752708
34MP0004185_abnormal_adipocyte_glucose1.34980864
35MP0002138_abnormal_hepatobiliary_system1.34714114
36MP0009643_abnormal_urine_homeostasis1.31966511
37MP0005330_cardiomyopathy1.30395636
38MP0005319_abnormal_enzyme/_coenzyme1.23900471
39MP0005670_abnormal_white_adipose1.22697105
40MP0001216_abnormal_epidermal_layer1.21121462
41MP0003868_abnormal_feces_composition1.20849885
42MP0010352_gastrointestinal_tract_polyps1.20105426
43MP0003566_abnormal_cell_adhesion1.19687501
44MP0002249_abnormal_larynx_morphology1.18318876
45MP0003329_amyloid_beta_deposits1.16544080
46MP0000566_synostosis1.16197888
47MP0005023_abnormal_wound_healing1.15656259
48MP0004264_abnormal_extraembryonic_tissu1.15073585
49MP0003300_gastrointestinal_ulcer1.14546625
50MP0002089_abnormal_postnatal_growth/wei1.12979731
51MP0005666_abnormal_adipose_tissue1.09674254
52MP0000467_abnormal_esophagus_morphology1.09223545
53MP0005076_abnormal_cell_differentiation1.09161241
54MP0004272_abnormal_basement_membrane1.08892279
55MP0005451_abnormal_body_composition1.08763326
56MP0001243_abnormal_dermal_layer1.08256076
57MP0000767_abnormal_smooth_muscle1.07045014
58MP0005257_abnormal_intraocular_pressure1.06646530
59MP0010771_integument_phenotype1.01986569
60MP0009053_abnormal_anal_canal0.99354363
61MP0005503_abnormal_tendon_morphology0.98736466
62MP0003879_abnormal_hair_cell0.98217954
63MP0003941_abnormal_skin_development0.97777753
64MP0001958_emphysema0.97464435
65MP0005508_abnormal_skeleton_morphology0.95506328
66MP0002098_abnormal_vibrissa_morphology0.94659592
67MP0006138_congestive_heart_failure0.94159259
68MP0001756_abnormal_urination0.93594916
69MP0005595_abnormal_vascular_smooth0.92229296
70MP0003091_abnormal_cell_migration0.92167486
71MP0004947_skin_inflammation0.91303436
72MP0000678_abnormal_parathyroid_gland0.91296462
73MP0002877_abnormal_melanocyte_morpholog0.91282029
74MP0001881_abnormal_mammary_gland0.90525224
75MP0004130_abnormal_muscle_cell0.88937628
76MP0000377_abnormal_hair_follicle0.87963192
77MP0008260_abnormal_autophagy0.86780083
78MP0009278_abnormal_bone_marrow0.86771986
79MP0005165_increased_susceptibility_to0.86704260
80MP0010678_abnormal_skin_adnexa0.86415765
81MP0005584_abnormal_enzyme/coenzyme_acti0.85905404
82MP0005084_abnormal_gallbladder_morpholo0.84791706
83MP0003172_abnormal_lysosome_physiology0.84583742
84MP0010368_abnormal_lymphatic_system0.84372531
85MP0005375_adipose_tissue_phenotype0.83356633
86MP0004510_myositis0.83149750
87MP0000462_abnormal_digestive_system0.83115737
88MP0003075_altered_response_to0.82926462
89MP0000427_abnormal_hair_cycle0.82159914
90MP0000604_amyloidosis0.81683400
91MP0002108_abnormal_muscle_morphology0.80948745
92MP0002971_abnormal_brown_adipose0.80288494
93MP0006054_spinal_hemorrhage0.79907715
94MP0000750_abnormal_muscle_regeneration0.78898726
95MP0005220_abnormal_exocrine_pancreas0.78718778
96MP0003186_abnormal_redox_activity0.77053787
97MP0000747_muscle_weakness0.76967609
98MP0000013_abnormal_adipose_tissue0.76755640
99MP0010030_abnormal_orbit_morphology0.76189752
100MP0000598_abnormal_liver_morphology0.75954885
101MP0005636_abnormal_mineral_homeostasis0.75735472
102MP0003183_abnormal_peptide_metabolism0.75531969
103MP0000647_abnormal_sebaceous_gland0.75155858
104MP0000003_abnormal_adipose_tissue0.74231590
105MP0009931_abnormal_skin_appearance0.73996139
106MP0003279_aneurysm0.71636942
107MP0001664_abnormal_digestion0.70168509
108MP0005623_abnormal_meninges_morphology0.70092304
109MP0004087_abnormal_muscle_fiber0.69855649
110MP0000534_abnormal_ureter_morphology0.69716946
111MP0000538_abnormal_urinary_bladder0.69004778
112MP0001764_abnormal_homeostasis0.68044489
113MP0000681_abnormal_thyroid_gland0.68013789
114MP0000762_abnormal_tongue_morphology0.67928016
115MP0002295_abnormal_pulmonary_circulatio0.66209829
116MP0004233_abnormal_muscle_weight0.66065417
117MP0001849_ear_inflammation0.65921313
118MP0000383_abnormal_hair_follicle0.65611029
119MP0002136_abnormal_kidney_physiology0.63496701
120MP0004782_abnormal_surfactant_physiolog0.62852331
121MP0005647_abnormal_sex_gland0.62247888
122MP0001191_abnormal_skin_condition0.61280934
123MP0002896_abnormal_bone_mineralization0.61128485
124MP0009379_abnormal_foot_pigmentation0.59738447
125MP0000477_abnormal_intestine_morphology0.59333503
126MP0000537_abnormal_urethra_morphology0.59320309
127MP0005408_hypopigmentation0.58842088
128MP0005448_abnormal_energy_balance0.58369862
129MP0001542_abnormal_bone_strength0.57093191
130MP0005334_abnormal_fat_pad0.56958583
131MP0009764_decreased_sensitivity_to0.55702999
132MP0009642_abnormal_blood_homeostasis0.54909789
133MP0003724_increased_susceptibility_to0.53750467
134MP0001661_extended_life_span0.52991611
135MP0001765_abnormal_ion_homeostasis0.52802425
136MP0009115_abnormal_fat_cell0.52191612

Predicted human phenotypes

RankGene SetZ-score
1Xanthomatosis (HP:0000991)5.14132409
2Intrahepatic cholestasis (HP:0001406)5.14041707
3Abnormality of monocarboxylic acid metabolism (HP:0010996)4.85893111
4Deep venous thrombosis (HP:0002625)4.85243293
5Abnormality of aromatic amino acid family metabolism (HP:0004338)4.46559639
6Hypobetalipoproteinemia (HP:0003563)4.28409097
7Right ventricular cardiomyopathy (HP:0011663)4.22538276
8Hyperlipoproteinemia (HP:0010980)3.93158882
9Hypolipoproteinemia (HP:0010981)3.88998538
10Hypoalphalipoproteinemia (HP:0003233)3.88330783
11Abnormality of glutamine family amino acid metabolism (HP:0010902)3.76677913
12Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.57760652
13Prolonged partial thromboplastin time (HP:0003645)3.51628826
14Vertebral compression fractures (HP:0002953)3.41586184
15Protrusio acetabuli (HP:0003179)3.39452261
16Malnutrition (HP:0004395)3.36180514
17Complement deficiency (HP:0004431)3.29206091
18Hyperammonemia (HP:0001987)3.27621203
19Fat malabsorption (HP:0002630)3.22876093
20Cervical subluxation (HP:0003308)3.22784864
21Systemic lupus erythematosus (HP:0002725)3.22671383
22Premature rupture of membranes (HP:0001788)3.22624580
23Epidermoid cyst (HP:0200040)3.20771427
24Hypoglycemic coma (HP:0001325)3.20703284
25Hyperglycinuria (HP:0003108)3.10858678
26Alopecia of scalp (HP:0002293)3.10044007
27Distal lower limb muscle weakness (HP:0009053)3.02767983
28Thin bony cortex (HP:0002753)3.02553784
29Abnormality of the common coagulation pathway (HP:0010990)2.97904602
30Ketosis (HP:0001946)2.94309103
31Ileus (HP:0002595)2.91025764
32Abnormality of glycine metabolism (HP:0010895)2.87046567
33Abnormality of serine family amino acid metabolism (HP:0010894)2.87046567
34Abnormality of the intrinsic pathway (HP:0010989)2.86229596
35Atrophic scars (HP:0001075)2.84653716
36Abnormality of sulfur amino acid metabolism (HP:0004339)2.82054944
37Abnormality of fatty-acid metabolism (HP:0004359)2.76968491
38Joint stiffness (HP:0001387)2.72458222
39Myocardial infarction (HP:0001658)2.70507769
40Abnormality of complement system (HP:0005339)2.69875588
41Conjugated hyperbilirubinemia (HP:0002908)2.66000338
42Increased connective tissue (HP:0009025)2.63413948
43Hyperglycinemia (HP:0002154)2.60796803
44Dysostosis multiplex (HP:0000943)2.59489266
45Mucopolysacchariduria (HP:0008155)2.57874953
46Urinary glycosaminoglycan excretion (HP:0003541)2.57874953
47Achilles tendon contracture (HP:0001771)2.57646366
48Hypercholesterolemia (HP:0003124)2.57344017
49Abnormality of aspartate family amino acid metabolism (HP:0010899)2.57292370
50Peritonitis (HP:0002586)2.56157329
51Short nail (HP:0001799)2.54165138
52Abnormality of purine metabolism (HP:0004352)2.52105068
53J-shaped sella turcica (HP:0002680)2.50671549
54Abnormality of mucopolysaccharide metabolism (HP:0011020)2.50190384
55Abnormality of polysaccharide metabolism (HP:0011012)2.50190384
56Abnormality of glycosaminoglycan metabolism (HP:0004371)2.50190384
57Cerebral aneurysm (HP:0004944)2.48851883
58Biconcave vertebral bodies (HP:0004586)2.47253866
59Plantar hyperkeratosis (HP:0007556)2.46884884
60Ketoacidosis (HP:0001993)2.45165223
61Blue sclerae (HP:0000592)2.45039824
62Fragile skin (HP:0001030)2.44277666
63Abnormality of proline metabolism (HP:0010907)2.42938034
64Hydroxyprolinuria (HP:0003080)2.42938034
65Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.39411956
66Flat acetabular roof (HP:0003180)2.33723897
67Stridor (HP:0010307)2.32955764
68Shallow orbits (HP:0000586)2.32607299
69Abnormal cartilage morphology (HP:0002763)2.31616839
70Milia (HP:0001056)2.31279396
71Upper limb amyotrophy (HP:0009129)2.31171492
72Distal upper limb amyotrophy (HP:0007149)2.31171492
73Mesangial abnormality (HP:0001966)2.30030124
74Hyperacusis (HP:0010780)2.28759456
75Skin nodule (HP:0200036)2.28685723
76Type 1 muscle fiber predominance (HP:0003803)2.27427022
77Testicular atrophy (HP:0000029)2.27266173
78Broad metatarsal (HP:0001783)2.27124922
79Ankle contracture (HP:0006466)2.27084498
80Abnormality of nucleobase metabolism (HP:0010932)2.26549584
81Onycholysis (HP:0001806)2.24794532
82Cardiovascular calcification (HP:0011915)2.23062504
83Glomerulonephritis (HP:0000099)2.22974197
84Abnormality of the distal phalanges of the toes (HP:0010182)2.22837062
85Bladder diverticulum (HP:0000015)2.22662652
86Lymphangioma (HP:0100764)2.21440439
87Joint hemorrhage (HP:0005261)2.19865084
88Distal lower limb amyotrophy (HP:0008944)2.19312815
89Gout (HP:0001997)2.18077615
90Dicarboxylic aciduria (HP:0003215)2.17525170
91Abnormality of dicarboxylic acid metabolism (HP:0010995)2.17525170
92Steatorrhea (HP:0002570)2.17385653
93Elbow flexion contracture (HP:0002987)2.15363754
94Esophageal varix (HP:0002040)2.15170819
95Conjunctival hamartoma (HP:0100780)2.14624562
96Increased variability in muscle fiber diameter (HP:0003557)2.12962617
97Acanthosis nigricans (HP:0000956)2.12430750
98Mildly elevated creatine phosphokinase (HP:0008180)2.11132718
99Palmoplantar hyperkeratosis (HP:0000972)2.10798019
100Asymmetric septal hypertrophy (HP:0001670)2.08184356
101Vascular calcification (HP:0004934)2.07918701
102Ulnar bowing (HP:0003031)2.07849507
103Generalized amyotrophy (HP:0003700)2.07122917
104Woolly hair (HP:0002224)2.06798849
105Vascular tortuosity (HP:0004948)2.05691768
106Wormian bones (HP:0002645)2.05254180
107Nephritis (HP:0000123)2.05099409
108Abnormality of methionine metabolism (HP:0010901)2.04373986
109Late onset (HP:0003584)2.03061637
110Broad face (HP:0000283)2.02926418
111Abnormality of the Achilles tendon (HP:0005109)2.01859180
112Abnormality of nail color (HP:0100643)2.00934340
113Coxa vara (HP:0002812)1.98805751
114Fragile nails (HP:0001808)1.98772554
115Axonal loss (HP:0003447)1.96764628
116Obstructive sleep apnea (HP:0002870)1.96183121
117Bulbar palsy (HP:0001283)1.96077386
118Neonatal onset (HP:0003623)1.94705383
119Metabolic acidosis (HP:0001942)1.94496669
120Aneurysm (HP:0002617)1.94122896
121Hyperbilirubinemia (HP:0002904)1.93757391
122Hemorrhage of the eye (HP:0011885)1.93430118
123Abdominal distention (HP:0003270)1.92933697
124Hepatocellular carcinoma (HP:0001402)1.92848663
125Pancreatitis (HP:0001733)1.91337611
126Hypertriglyceridemia (HP:0002155)1.90765927
127Follicular hyperkeratosis (HP:0007502)1.90357493
128Aortic regurgitation (HP:0001659)1.89831013
129Palmar hyperkeratosis (HP:0010765)1.87528733
130Hyperglycemia (HP:0003074)1.87162313
131Osteolytic defects of the phalanges of the hand (HP:0009771)1.86303759
132Osteolytic defects of the hand bones (HP:0009699)1.86303759
133Abnormality of dentin (HP:0010299)1.85776852
134Flat capital femoral epiphysis (HP:0003370)1.85361005
135Aortic aneurysm (HP:0004942)1.84925066
136Abnormal delivery (HP:0001787)1.84364172
137Nonimmune hydrops fetalis (HP:0001790)1.83000698
138Abnormality of carpal bone ossification (HP:0006257)1.82850821
139Mitral stenosis (HP:0001718)1.82586318
140Aortic dissection (HP:0002647)1.81680923
141Long toe (HP:0010511)1.80105747
142Arterial tortuosity (HP:0005116)1.79076560
143Abnormality of skeletal muscle fiber size (HP:0012084)1.79013583
144Cerebral palsy (HP:0100021)1.78906225
145Generalized aminoaciduria (HP:0002909)1.78667222
146Infantile muscular hypotonia (HP:0008947)1.78219383
147Ectopia lentis (HP:0001083)1.77466000
148Flattened epiphyses (HP:0003071)1.77155261
149Back pain (HP:0003418)1.76969253
150Soft skin (HP:0000977)1.76695140
151Cholelithiasis (HP:0001081)1.76320198
152Mitral regurgitation (HP:0001653)1.76270814
153Lethargy (HP:0001254)1.75808068
154Abnormality of pyrimidine metabolism (HP:0004353)1.75438617
155Abnormal gallbladder morphology (HP:0012437)1.75173619
156Nuclear cataract (HP:0100018)1.75142781
157Hyperuricemia (HP:0002149)1.73327377
158Increased purine levels (HP:0004368)1.73327377
159Abnormality of the acetabulum (HP:0003170)1.72058393
160Acanthocytosis (HP:0001927)1.71624901
161Spinal rigidity (HP:0003306)1.71556982
162Abnormal gallbladder physiology (HP:0012438)1.70448454
163Osteoarthritis (HP:0002758)1.69555514
164Growth hormone excess (HP:0000845)1.69238654
165Exercise-induced myalgia (HP:0003738)1.69067447

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R5.15353711
2ERN14.30720754
3TRIB33.50969661
4BCKDK3.37271252
5FRK2.92457083
6SIK12.71298879
7MET2.47697595
8EPHA22.34290318
9PKN22.34150939
10FGFR42.21763298
11PIK3CA2.15722362
12LATS12.01675792
13TTN2.01212889
14MAP3K32.01078220
15ICK2.00904396
16DDR21.89707715
17PDGFRA1.87534879
18MAP2K21.87389399
19IRAK31.87079121
20PTK61.86682682
21PIK3CG1.72152694
22SMG11.68329023
23RIPK11.63200831
24FER1.59350323
25MAP3K21.57142009
26MAPKAPK31.55193042
27PRKD21.54926522
28LIMK11.50767470
29TESK21.50114686
30ARAF1.49927931
31EPHB21.48279959
32MAP3K61.48099059
33MAP2K11.46155363
34LMTK21.44992537
35PRPF4B1.42029663
36PTK21.34267612
37MUSK1.32524999
38MAP2K31.23262188
39TAOK31.21335102
40FLT31.18529855
41TAOK11.17800317
42LRRK21.17688687
43EEF2K1.17528353
44MAP3K111.17427336
45EPHA31.17037202
46CDC42BPA1.16835443
47BMX1.14951907
48NTRK11.08811863
49RPS6KA21.06237069
50EPHB11.05992536
51ERBB41.03107122
52PRKD31.00417027
53KSR20.96413365
54MYLK0.91123367
55TESK10.90354703
56PRKG20.87418973
57LATS20.86564033
58TGFBR20.86204595
59MAPK110.85597569
60NEK90.84692465
61RPS6KB20.83795446
62VRK20.82859185
63MAP2K60.81659115
64NME10.81029632
65FGFR20.79577792
66MAP3K10.78868194
67MAP3K100.78581841
68SCYL20.75557541
69MARK20.75547402
70PAK20.71897964
71CAMK1D0.71731698
72TRPM70.70612048
73PDPK10.70513813
74TNK20.69950032
75INSRR0.68185769
76RPS6KA40.67245772
77STK38L0.67138858
78RPS6KL10.64737654
79RPS6KC10.64737654
80KDR0.63425431
81MST40.63103222
82STK380.62432420
83MAP3K70.61650580
84MAP3K80.60374506
85ABL20.60124315
86PHKG20.58863204
87PHKG10.58863204
88TYK20.58710260
89CDK60.58556010
90KIT0.58272450
91ERBB20.56698917
92TGFBR10.56666103
93RPS6KA60.56381451
94TAOK20.56245352
95PAK40.55815036
96MTOR0.55256143
97NUAK10.55003794
98DYRK1B0.53975747
99PAK30.53240152
100PRKAA20.52339990
101MAPK150.51661863
102PIM20.51578565
103ZAP700.50599939
104FGFR10.49080232
105TBK10.48189016
106IRAK20.47670713
107PDGFRB0.46970585
108JAK20.45765679
109STK100.45470866
110JAK10.45103948
111HIPK20.44142455
112RET0.43915377
113ILK0.43655264
114GSK3A0.42600937
115PDK40.41378815
116PDK30.41378815
117PDK20.40988588
118PRKCI0.40203269
119ROCK10.38788280
120CAMK2G0.38283526
121CDK80.37398980
122MAPK120.36407285
123FGFR30.35597170
124CAMK2D0.35447112
125DAPK30.34063950
126DMPK0.33832179
127MOS0.32893240
128CAMK2B0.32830837
129CAMK1G0.32703733
130MAPK40.30787713
131MAPKAPK20.28821019
132CHUK0.28570477
133NME20.28062937
134STK30.28061250
135GRK60.26584894
136PRKD10.26175782
137TIE10.25994591

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.36187538
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.12391513
3Nitrogen metabolism_Homo sapiens_hsa009102.67290800
4Fatty acid degradation_Homo sapiens_hsa000712.55505092
5Arginine biosynthesis_Homo sapiens_hsa002202.53202530
6Tryptophan metabolism_Homo sapiens_hsa003802.50717949
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.41002146
8Sulfur metabolism_Homo sapiens_hsa009202.33045376
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.31938484
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.27810891
11Fat digestion and absorption_Homo sapiens_hsa049752.27630918
12Other glycan degradation_Homo sapiens_hsa005112.22571611
13Glycosaminoglycan degradation_Homo sapiens_hsa005312.20342919
14PPAR signaling pathway_Homo sapiens_hsa033202.17745469
15Caffeine metabolism_Homo sapiens_hsa002322.14681694
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.13514932
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.04778801
18Complement and coagulation cascades_Homo sapiens_hsa046101.98852472
19Histidine metabolism_Homo sapiens_hsa003401.95073173
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.92953227
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.90867625
22Chemical carcinogenesis_Homo sapiens_hsa052041.90815706
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.90046707
24Butanoate metabolism_Homo sapiens_hsa006501.88691414
25Propanoate metabolism_Homo sapiens_hsa006401.83885266
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.73875829
27Fatty acid metabolism_Homo sapiens_hsa012121.73593349
28Bile secretion_Homo sapiens_hsa049761.73094411
29Peroxisome_Homo sapiens_hsa041461.71271407
30beta-Alanine metabolism_Homo sapiens_hsa004101.57912625
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51033185
32Starch and sucrose metabolism_Homo sapiens_hsa005001.49218299
33Folate biosynthesis_Homo sapiens_hsa007901.46788991
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.46422872
35Phenylalanine metabolism_Homo sapiens_hsa003601.43498108
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.42417235
37Retinol metabolism_Homo sapiens_hsa008301.42416643
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.40052788
39Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.36330177
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.34671928
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33375292
42Pyruvate metabolism_Homo sapiens_hsa006201.29119253
43Selenocompound metabolism_Homo sapiens_hsa004501.22614800
44Carbon metabolism_Homo sapiens_hsa012001.21950267
45Tyrosine metabolism_Homo sapiens_hsa003501.21304632
46Maturity onset diabetes of the young_Homo sapiens_hsa049501.21122253
47Vitamin digestion and absorption_Homo sapiens_hsa049771.17828978
48ABC transporters_Homo sapiens_hsa020101.10403820
49Staphylococcus aureus infection_Homo sapiens_hsa051501.09349696
50Sulfur relay system_Homo sapiens_hsa041221.09043069
51Lysosome_Homo sapiens_hsa041421.07398996
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.06983118
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.05959798
54Biosynthesis of amino acids_Homo sapiens_hsa012301.05331152
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.04326206
56Glutathione metabolism_Homo sapiens_hsa004801.03868481
57Fatty acid elongation_Homo sapiens_hsa000621.03094247
58Arginine and proline metabolism_Homo sapiens_hsa003301.03046429
59Glycerolipid metabolism_Homo sapiens_hsa005611.01276724
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00618600
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90451576
62Protein digestion and absorption_Homo sapiens_hsa049740.84088322
63Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.83675958
64Galactose metabolism_Homo sapiens_hsa000520.83118807
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.81884211
66Mineral absorption_Homo sapiens_hsa049780.81842297
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79595231
68Notch signaling pathway_Homo sapiens_hsa043300.78918715
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76729614
70Bladder cancer_Homo sapiens_hsa052190.73421569
71Steroid biosynthesis_Homo sapiens_hsa001000.72818885
72Sphingolipid metabolism_Homo sapiens_hsa006000.72793767
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71093120
74Fructose and mannose metabolism_Homo sapiens_hsa000510.70682176
75Renin-angiotensin system_Homo sapiens_hsa046140.68548122
76Dilated cardiomyopathy_Homo sapiens_hsa054140.66094487
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66047965
78Linoleic acid metabolism_Homo sapiens_hsa005910.65231116
79Pentose phosphate pathway_Homo sapiens_hsa000300.62646153
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60478244
81Lysine degradation_Homo sapiens_hsa003100.60014363
82VEGF signaling pathway_Homo sapiens_hsa043700.59655408
83Fatty acid biosynthesis_Homo sapiens_hsa000610.57935832
84ECM-receptor interaction_Homo sapiens_hsa045120.55741064
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54879927
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53583026
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50281293
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49338827
89Ovarian steroidogenesis_Homo sapiens_hsa049130.45668177
90Insulin resistance_Homo sapiens_hsa049310.43448223
91N-Glycan biosynthesis_Homo sapiens_hsa005100.41834257
92Pertussis_Homo sapiens_hsa051330.41582287
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.40833318
94Metabolic pathways_Homo sapiens_hsa011000.40228106
95Arachidonic acid metabolism_Homo sapiens_hsa005900.36483550
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.35252720
97Amoebiasis_Homo sapiens_hsa051460.34885106
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33839733
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.30931779
100Vibrio cholerae infection_Homo sapiens_hsa051100.29934510
101GnRH signaling pathway_Homo sapiens_hsa049120.27253327
102Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24627213
103Adherens junction_Homo sapiens_hsa045200.23689728
104Tight junction_Homo sapiens_hsa045300.22225530
105Vitamin B6 metabolism_Homo sapiens_hsa007500.20163052
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.20090804
107Focal adhesion_Homo sapiens_hsa045100.18767249
108Prion diseases_Homo sapiens_hsa050200.18142591
109Thyroid cancer_Homo sapiens_hsa052160.17961063
110AMPK signaling pathway_Homo sapiens_hsa041520.17485550
111One carbon pool by folate_Homo sapiens_hsa006700.17226555
112Proteoglycans in cancer_Homo sapiens_hsa052050.15012192
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.14832665
114Thyroid hormone synthesis_Homo sapiens_hsa049180.12604454
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.11135644
116Pancreatic secretion_Homo sapiens_hsa049720.10518978
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.09571667
118Glucagon signaling pathway_Homo sapiens_hsa049220.08359316
119Hepatitis C_Homo sapiens_hsa051600.08163308
120Insulin signaling pathway_Homo sapiens_hsa049100.05324984

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