IL17C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a T cell-derived cytokine that shares the sequence similarity with IL17. This cytokine was reported to stimulate the release of tumor necrosis factor alpha and interleukin 1 beta from a monocytic cell line. The expression of this cytokine was found to be restricted to activated T cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand renaturation (GO:0000733)8.50380102
2mitotic cell cycle arrest (GO:0071850)7.66875430
3lens fiber cell differentiation (GO:0070306)6.92503899
4transepithelial transport (GO:0070633)6.33014735
5negative regulation of cell aging (GO:0090344)6.25238348
6cellular response to ATP (GO:0071318)6.23704065
7regulation of skeletal muscle contraction (GO:0014819)6.18330869
8NIK/NF-kappaB signaling (GO:0038061)6.13980138
9DNA replication checkpoint (GO:0000076)5.92628104
10peptidyl-glutamic acid carboxylation (GO:0017187)5.67711084
11protein carboxylation (GO:0018214)5.67711084
12positive regulation of heat generation (GO:0031652)5.64474031
13adenosine receptor signaling pathway (GO:0001973)5.53565384
14regulation of nuclear cell cycle DNA replication (GO:0033262)5.40785016
15meiotic chromosome segregation (GO:0045132)5.28641074
16regulation of RIG-I signaling pathway (GO:0039535)5.24051674
17regulation of phospholipid biosynthetic process (GO:0071071)5.05685408
18GDP-mannose metabolic process (GO:0019673)4.88124177
19positive regulation of gamma-delta T cell activation (GO:0046645)4.78615132
20chromatin remodeling at centromere (GO:0031055)4.73929274
21G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.68739033
22CENP-A containing nucleosome assembly (GO:0034080)4.63500891
23regulation of synapse structural plasticity (GO:0051823)4.53227137
24detection of light stimulus involved in sensory perception (GO:0050962)4.52963712
25detection of light stimulus involved in visual perception (GO:0050908)4.52963712
26estrogen biosynthetic process (GO:0006703)4.41274269
27modulation by symbiont of host cellular process (GO:0044068)4.40944929
28iron ion import (GO:0097286)4.28750319
29regulation of heat generation (GO:0031650)4.19581810
30histone exchange (GO:0043486)4.17536427
31regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)4.17308943
32regulation of extracellular matrix disassembly (GO:0010715)4.12676929
33purinergic nucleotide receptor signaling pathway (GO:0035590)4.11637480
34rRNA methylation (GO:0031167)4.10405990
35positive regulation by symbiont of host defense response (GO:0052509)4.06584484
36modulation by symbiont of host defense response (GO:0052031)4.06584484
37modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.06584484
38modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.06584484
39positive regulation by organism of defense response of other organism involved in symbiotic interact4.06584484
40modulation by symbiont of host immune response (GO:0052553)4.06584484
41response to muramyl dipeptide (GO:0032495)3.93683995
42rRNA modification (GO:0000154)3.91001354
43nucleotide-sugar biosynthetic process (GO:0009226)3.78982508
44regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.78367987
45regulation of mitotic spindle checkpoint (GO:1903504)3.78367987
46positive thymic T cell selection (GO:0045059)3.75065773
47leukocyte migration involved in inflammatory response (GO:0002523)3.66169818
48folic acid transport (GO:0015884)3.61958820
49regulation of protein polyubiquitination (GO:1902914)3.60093274
50piRNA metabolic process (GO:0034587)3.59330013
51transcription elongation from RNA polymerase III promoter (GO:0006385)3.51973779
52termination of RNA polymerase III transcription (GO:0006386)3.51973779
53DNA replication-independent nucleosome organization (GO:0034724)3.51248959
54DNA replication-independent nucleosome assembly (GO:0006336)3.51248959
55negative regulation of interleukin-1 beta production (GO:0032691)3.50934583
56regulation of necroptotic process (GO:0060544)3.49568326
57negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.46931951
58negative regulation of cell killing (GO:0031342)3.46931951
59phosphatidylglycerol biosynthetic process (GO:0006655)3.44238753
60neutrophil activation involved in immune response (GO:0002283)3.42964718
61nucleoside transmembrane transport (GO:1901642)3.41263375
62negative regulation of necroptotic process (GO:0060546)3.39786501
63negative regulation of DNA-dependent DNA replication (GO:2000104)3.38803424
64base-excision repair, AP site formation (GO:0006285)3.38397580
65pseudouridine synthesis (GO:0001522)3.37482273
66N-terminal protein amino acid modification (GO:0031365)3.34211638
67regulation of gamma-delta T cell activation (GO:0046643)3.32517423
68regulation of ARF GTPase activity (GO:0032312)3.31147304
69macrophage activation involved in immune response (GO:0002281)3.30501393
70negative regulation of telomerase activity (GO:0051974)3.30435741
71respiratory chain complex IV assembly (GO:0008535)3.28722201
72regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.28088706
73response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.27972389
74response to host immune response (GO:0052572)3.27972389
75establishment of spindle orientation (GO:0051294)3.27797507
76positive regulation of humoral immune response (GO:0002922)3.26688080
77proteasome assembly (GO:0043248)3.26484760
78negative regulation of interleukin-12 production (GO:0032695)3.24636001
79response to host defenses (GO:0052200)3.22765690
80response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.22765690
81response to host (GO:0075136)3.22765690
82negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.19423105
83tolerance induction (GO:0002507)3.19151622
84response to lipoprotein particle (GO:0055094)3.16141859
85semaphorin-plexin signaling pathway (GO:0071526)3.15172471
86positive regulation of Cdc42 GTPase activity (GO:0043089)3.15158795
87regulation of helicase activity (GO:0051095)3.13633001
88determination of adult lifespan (GO:0008340)3.12726184
89positive regulation of extracellular matrix organization (GO:1903055)3.12445214
90negative regulation of interleukin-8 production (GO:0032717)3.12085047
91behavioral response to nicotine (GO:0035095)3.11083986
92regulation of telomere maintenance via telomerase (GO:0032210)3.09903418
93regulation of interferon-beta biosynthetic process (GO:0045357)3.09861645
94purinergic receptor signaling pathway (GO:0035587)3.09394321
95response to ATP (GO:0033198)3.08982198
96purine deoxyribonucleotide catabolic process (GO:0009155)3.07465775
97DNA damage response, signal transduction resulting in transcription (GO:0042772)3.07300259
98citrulline biosynthetic process (GO:0019240)3.06464972
99heme transport (GO:0015886)3.06231709
100grooming behavior (GO:0007625)3.05655121
101interkinetic nuclear migration (GO:0022027)3.04137008
102regulation of cell aging (GO:0090342)3.03999046
103protein localization to chromosome, centromeric region (GO:0071459)3.03399563
104neutrophil mediated immunity (GO:0002446)3.03288538
105regulation of gamma-delta T cell differentiation (GO:0045586)3.02551770
106reciprocal DNA recombination (GO:0035825)3.02275417
107reciprocal meiotic recombination (GO:0007131)3.02275417
108mRNA cleavage (GO:0006379)3.02239426
109B cell homeostasis (GO:0001782)3.00889153
110establishment of mitotic spindle orientation (GO:0000132)3.00220497
111magnesium ion transport (GO:0015693)2.99209292
112somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.96415101
113isotype switching (GO:0045190)2.96415101
114somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.96415101
115regulation of histone H3-K27 methylation (GO:0061085)2.96394906
116G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.93961212
117dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.91636045
118vesicle transport along microtubule (GO:0047496)2.90960487
119mismatch repair (GO:0006298)2.89510498
120regulation of interleukin-12 biosynthetic process (GO:0045075)2.88791489
121cell adhesion mediated by integrin (GO:0033627)2.88012736
122DNA duplex unwinding (GO:0032508)2.87370460
123leukocyte aggregation (GO:0070486)2.86611259
124IMP biosynthetic process (GO:0006188)2.84457580
125negative regulation of DNA replication (GO:0008156)2.84368560
126meiotic cell cycle (GO:0051321)2.84267457
127positive regulation of B cell differentiation (GO:0045579)2.82528644
128establishment of mitotic spindle localization (GO:0040001)2.81368688
129somatic hypermutation of immunoglobulin genes (GO:0016446)2.80843290
130somatic diversification of immune receptors via somatic mutation (GO:0002566)2.80843290
131purine nucleobase biosynthetic process (GO:0009113)2.79690975
132regulation of B cell receptor signaling pathway (GO:0050855)2.79127609
133DNA methylation involved in gamete generation (GO:0043046)2.79090479
134cilium or flagellum-dependent cell motility (GO:0001539)2.78935777
135multicellular organism reproduction (GO:0032504)2.78907732
136establishment of spindle localization (GO:0051293)2.78436192
137L-amino acid import (GO:0043092)2.76958559
138regulation of double-strand break repair via homologous recombination (GO:0010569)2.76881499
139DNA geometric change (GO:0032392)2.76540112
140G2 DNA damage checkpoint (GO:0031572)2.75655618
141negative regulation of interleukin-1 production (GO:0032692)2.75617941
142germinal center formation (GO:0002467)2.75539550
143cytokine secretion (GO:0050663)2.75248544
144DNA replication-dependent nucleosome assembly (GO:0006335)2.74416756
145DNA replication-dependent nucleosome organization (GO:0034723)2.74416756
146myeloid cell homeostasis (GO:0002262)2.74066569
147myeloid dendritic cell differentiation (GO:0043011)2.73613687
148sensory perception of taste (GO:0050909)2.73473043
149intra-S DNA damage checkpoint (GO:0031573)2.73435434
150regulation of toll-like receptor signaling pathway (GO:0034121)2.72628550
151chromatin assembly or disassembly (GO:0006333)2.72036916
152N-terminal protein amino acid acetylation (GO:0006474)2.71797014
153response to peptidoglycan (GO:0032494)2.71775400
154cardiolipin metabolic process (GO:0032048)2.71252551
155phosphate ion homeostasis (GO:0055062)2.71178771
156trivalent inorganic anion homeostasis (GO:0072506)2.71178771
157kinetochore assembly (GO:0051382)2.70821832
158natural killer cell mediated cytotoxicity (GO:0042267)2.70752560
159natural killer cell mediated immunity (GO:0002228)2.70752560
160tRNA modification (GO:0006400)2.70680418
161negative regulation of telomere maintenance (GO:0032205)2.70449007
162response to laminar fluid shear stress (GO:0034616)2.70219112
163B cell receptor signaling pathway (GO:0050853)2.69918692
164heterotypic cell-cell adhesion (GO:0034113)2.68749833
165regulation of alkaline phosphatase activity (GO:0010692)2.68111516
166exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.67983403
167female gamete generation (GO:0007292)2.67131250
168positive regulation of acute inflammatory response (GO:0002675)2.66624632
169positive regulation of osteoblast proliferation (GO:0033690)2.66132583
170sulfur amino acid catabolic process (GO:0000098)2.65698696
171negative regulation of lipid storage (GO:0010888)2.65539813
172deoxyribonucleotide catabolic process (GO:0009264)2.65229769
173modification by symbiont of host morphology or physiology (GO:0044003)2.64666437
174regulation of superoxide anion generation (GO:0032928)2.63916155
175regulation of DNA methylation (GO:0044030)2.61949671
176regulation of plasminogen activation (GO:0010755)2.60456370
177positive regulation of protein homooligomerization (GO:0032464)2.58353436
178neutrophil activation (GO:0042119)2.58194176
179myeloid dendritic cell activation (GO:0001773)2.55901388
180regulation of meiosis (GO:0040020)2.55743975
181negative regulation of execution phase of apoptosis (GO:1900118)2.54438495
182autophagic vacuole fusion (GO:0000046)2.54075983
183regulation of cytokine secretion involved in immune response (GO:0002739)2.52842810
184modulation by virus of host process (GO:0019054)2.51796750
185positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.49401505
186positive T cell selection (GO:0043368)2.48911121
187negative regulation of necrotic cell death (GO:0060547)2.47091782
188amyloid precursor protein catabolic process (GO:0042987)2.45402080
189regulation of interleukin-8 biosynthetic process (GO:0045414)2.44228284
190mitotic chromosome condensation (GO:0007076)2.43479584
191leukocyte cell-cell adhesion (GO:0007159)2.42500863
192regulation of Cdc42 GTPase activity (GO:0043088)2.40896520
193DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.39730796
194response to protozoan (GO:0001562)2.39524533
195zinc ion transmembrane transport (GO:0071577)2.39317542
196wound healing, spreading of epidermal cells (GO:0035313)2.38827168

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.73953733
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.70690252
3SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.45390214
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.20633052
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.16331317
6XRN2_22483619_ChIP-Seq_HELA_Human3.10513296
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.93978947
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.93639478
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.89533306
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.89470511
11DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.88558217
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.85987082
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.76091761
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.65545905
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.58226686
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.56860580
17WT1_19549856_ChIP-ChIP_CCG9911_Human2.56725785
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.55844851
19IRF8_22096565_ChIP-ChIP_GC-B_Human2.53302188
20CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.50886203
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.50125889
22P68_20966046_ChIP-Seq_HELA_Human2.49174396
23Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.47465824
24MYB_21317192_ChIP-Seq_ERMYB_Mouse2.45198910
25E2F4_17652178_ChIP-ChIP_JURKAT_Human2.44222434
26SPI1_23127762_ChIP-Seq_K562_Human2.42331724
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.40579251
28TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.40452762
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.38508962
30TP63_19390658_ChIP-ChIP_HaCaT_Human2.37744745
31SMAD_19615063_ChIP-ChIP_OVARY_Human2.35021072
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.29045957
33GABP_17652178_ChIP-ChIP_JURKAT_Human2.28973553
34NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human2.25362235
35VDR_21846776_ChIP-Seq_THP-1_Human2.18561292
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.14566135
37STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.10000192
38E2F1_20622854_ChIP-Seq_HELA_Human2.06792371
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.99986397
40CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.99626088
41* TCF7_22412390_ChIP-Seq_EML_Mouse1.95278215
42* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.94348746
43BCOR_27268052_Chip-Seq_Bcells_Human1.91743305
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.90670702
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.88988528
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.88758896
47DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.88060871
48SCL_19346495_ChIP-Seq_HPC-7_Human1.87760551
49MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.86792456
50ETS1_20019798_ChIP-Seq_JURKAT_Human1.85913480
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.84968277
52PHF8_20622854_ChIP-Seq_HELA_Human1.84197455
53FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.84108674
54VDR_24763502_ChIP-Seq_THP-1_Human1.83121750
55RXRA_24833708_ChIP-Seq_LIVER_Mouse1.81808184
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.78906450
57FOXP1_21924763_ChIP-Seq_HESCs_Human1.78021151
58ESR2_21235772_ChIP-Seq_MCF-7_Human1.76592251
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.76370808
60BCL6_27268052_Chip-Seq_Bcells_Human1.74188956
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.74087989
62ESR1_21235772_ChIP-Seq_MCF-7_Human1.73830787
63EST1_17652178_ChIP-ChIP_JURKAT_Human1.72068111
64RARA_24833708_ChIP-Seq_LIVER_Mouse1.71907041
65* RUNX1_22412390_ChIP-Seq_EML_Mouse1.69911965
66KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.69650966
67KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.69650966
68KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.69650966
69* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.69395713
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.68796886
71RARB_24833708_ChIP-Seq_LIVER_Mouse1.68057395
72KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.68029803
73LXR_22292898_ChIP-Seq_THP-1_Human1.67357271
74MYC_18358816_ChIP-ChIP_MESCs_Mouse1.66874970
75CTCF_21964334_Chip-Seq_Bcells_Human1.64968668
76VDR_23849224_ChIP-Seq_CD4+_Human1.64460127
77RUNX_20019798_ChIP-Seq_JUKART_Human1.63410234
78YY1_22570637_ChIP-Seq_MALME-3M_Human1.63091490
79MYC_19030024_ChIP-ChIP_MESCs_Mouse1.61106162
80FOXP3_21729870_ChIP-Seq_TREG_Human1.61100830
81KDM2B_26808549_Chip-Seq_DND41_Human1.57885127
82IKZF1_21737484_ChIP-ChIP_HCT116_Human1.57083562
83GABP_19822575_ChIP-Seq_HepG2_Human1.56912279
84IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.55763582
85GATA2_21666600_ChIP-Seq_HMVEC_Human1.54162406
86E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.54029566
87CTCF_27219007_Chip-Seq_Bcells_Human1.53702259
88FOXO3_23340844_ChIP-Seq_DLD1_Human1.51333076
89HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.48370692
90VDR_24787735_ChIP-Seq_THP-1_Human1.48336106
91RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.47312875
92* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.46469652
93NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.46116512
94SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46088996
95MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.45244018
96PU_27001747_Chip-Seq_BMDM_Mouse1.44751395
97TET1_21451524_ChIP-Seq_MESCs_Mouse1.44260644
98GATA3_27048872_Chip-Seq_THYMUS_Human1.44176064
99IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.42939750
100* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.42891321
101MAF_26560356_Chip-Seq_TH1_Human1.40082343
102CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39967565
103* NANOG_20526341_ChIP-Seq_ESCs_Human1.39935143
104HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.39075088
105ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.38908549
106AR_21572438_ChIP-Seq_LNCaP_Human1.38510133
107DCP1A_22483619_ChIP-Seq_HELA_Human1.38373903
108CREB1_15753290_ChIP-ChIP_HEK293T_Human1.37785992
109MYC_22102868_ChIP-Seq_BL_Human1.37487100
110KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.36771534
111PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36588259
112CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.35539009
113CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.32651270
114GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32485495
115SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.32299608
116ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.31415790
117CTCF_21964334_ChIP-Seq_BJAB-B_Human1.31287082
118THAP11_20581084_ChIP-Seq_MESCs_Mouse1.29928342
119YY1_21170310_ChIP-Seq_MESCs_Mouse1.29696361
120MYB_26560356_Chip-Seq_TH1_Human1.29267731
121EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.29035378
122NELFA_20434984_ChIP-Seq_ESCs_Mouse1.27209393
123PPAR_26484153_Chip-Seq_NCI-H1993_Human1.26488819
124MYB_26560356_Chip-Seq_TH2_Human1.26020679
125STAT4_19710469_ChIP-ChIP_TH1__Mouse1.25908039
126GATA2_19941826_ChIP-Seq_K562_Human1.25733539
127BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.25722843
128* CTCF_20526341_ChIP-Seq_ESCs_Human1.25299591
129MYC_18555785_ChIP-Seq_MESCs_Mouse1.24963142
130GATA1_19941826_ChIP-Seq_K562_Human1.24163327
131CIITA_25753668_ChIP-Seq_RAJI_Human1.24156500
132ELK3_25401928_ChIP-Seq_HUVEC_Human1.23831756
133ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22598487
134SPI1_23547873_ChIP-Seq_NB4_Human1.22172747
135CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20694943
136CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18016021
137UTX_26944678_Chip-Seq_JUKART_Human1.17886975
138TP63_17297297_ChIP-ChIP_HaCaT_Human1.17328218
139KDM2B_26808549_Chip-Seq_JURKAT_Human1.16643780
140NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.15600621
141SA1_27219007_Chip-Seq_ERYTHROID_Human1.14718743
142EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14554210
143ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14549750
144ETS1_21867929_ChIP-Seq_TH2_Mouse1.13193927
145* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13042656
146RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12567328
147PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11975980
148SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10245800
149* KDM2B_26808549_Chip-Seq_K562_Human1.09500969
150EWS_26573619_Chip-Seq_HEK293_Human1.09276751
151TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08892707
152* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07829086
153GATA1_26923725_Chip-Seq_HPCs_Mouse1.07718976
154P53_21459846_ChIP-Seq_SAOS-2_Human1.06831020
155RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.06391588
156SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05800450
157ERA_21632823_ChIP-Seq_H3396_Human1.05303782
158SA1_27219007_Chip-Seq_Bcells_Human1.04277728
159SRF_21415370_ChIP-Seq_HL-1_Mouse1.04265780
160GATA1_19941827_ChIP-Seq_MEL_Mouse1.03491293
161SMC4_20622854_ChIP-Seq_HELA_Human1.03313003
162STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03054940
163PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02183482
164PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01969728
165E2F1_21310950_ChIP-Seq_MCF-7_Human1.01922035
166TTF2_22483619_ChIP-Seq_HELA_Human1.01376727
167KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01365430
168* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00734559
169P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97828087
170MAF_26560356_Chip-Seq_TH2_Human0.97700822
171VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97487479
172RXR_22108803_ChIP-Seq_LS180_Human0.96529201
173CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93017814
174FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.92161735
175PKCTHETA_26484144_Chip-Seq_BREAST_Human0.92039374
176FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.90520311
177CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90003122
178ELK4_26923725_Chip-Seq_MESODERM_Mouse0.88784948
179STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.86551457
180* RACK7_27058665_Chip-Seq_MCF-7_Human0.86429221
181TP53_16413492_ChIP-PET_HCT116_Human0.86154807
182GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.86086817
183LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.84841388
184AR_21909140_ChIP-Seq_LNCAP_Human0.84639825
185GATA3_26560356_Chip-Seq_TH2_Human0.83916774
186HIF1A_21447827_ChIP-Seq_MCF-7_Human0.83339713
187EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.83116702
188SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.83008447
189GATA2_22383799_ChIP-Seq_G1ME_Mouse0.82327726
190P53_22127205_ChIP-Seq_FIBROBLAST_Human0.81784366

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation5.38703697
2MP0003136_yellow_coat_color5.27979450
3MP0005257_abnormal_intraocular_pressure5.20157666
4MP0001986_abnormal_taste_sensitivity4.54938998
5MP0000569_abnormal_digit_pigmentation4.17866539
6MP0003303_peritoneal_inflammation4.10998110
7MP0001188_hyperpigmentation4.06306571
8MP0005423_abnormal_somatic_nervous3.31694107
9MP0003941_abnormal_skin_development3.24120774
10MP0003111_abnormal_nucleus_morphology3.16183771
11MP0008875_abnormal_xenobiotic_pharmacok2.84941863
12MP0000685_abnormal_immune_system2.83546364
13MP0003693_abnormal_embryo_hatching2.72868616
14MP0005387_immune_system_phenotype2.70348407
15MP0001790_abnormal_immune_system2.70348407
16MP0004510_myositis2.69057157
17MP0003718_maternal_effect2.65203119
18MP0005451_abnormal_body_composition2.54728825
19MP0002254_reproductive_system_inflammat2.54618844
20MP0005058_abnormal_lysosome_morphology2.53654523
21MP0002160_abnormal_reproductive_system2.52114104
22MP0001800_abnormal_humoral_immune2.41893365
23MP0000465_gastrointestinal_hemorrhage2.40792367
24MP0001835_abnormal_antigen_presentation2.38522749
25MP0009840_abnormal_foam_cell2.37889709
26MP0003436_decreased_susceptibility_to2.36004546
27MP0003724_increased_susceptibility_to2.33342732
28MP0009278_abnormal_bone_marrow2.26964064
29MP0004957_abnormal_blastocyst_morpholog2.23051974
30MP0008260_abnormal_autophagy2.22501623
31MP0002419_abnormal_innate_immunity2.21057047
32MP0005000_abnormal_immune_tolerance2.18775092
33MP0002452_abnormal_antigen_presenting2.12386700
34MP0004947_skin_inflammation2.01529672
35MP0003806_abnormal_nucleotide_metabolis2.01065913
36MP0005501_abnormal_skin_physiology2.00398310
37MP0000604_amyloidosis2.00250391
38MP0003172_abnormal_lysosome_physiology1.92762535
39MP0002723_abnormal_immune_serum1.92276343
40MP0003300_gastrointestinal_ulcer1.86417692
41MP0005310_abnormal_salivary_gland1.81276724
42MP0008058_abnormal_DNA_repair1.81210705
43MP0001756_abnormal_urination1.80449032
44MP0008057_abnormal_DNA_replication1.74534188
45MP0005025_abnormal_response_to1.74089067
46MP0002736_abnormal_nociception_after1.73667304
47MP0002420_abnormal_adaptive_immunity1.72727806
48MP0001819_abnormal_immune_cell1.72221007
49MP0005410_abnormal_fertilization1.71855748
50MP0001919_abnormal_reproductive_system1.69390953
51MP0000751_myopathy1.69181856
52MP0005330_cardiomyopathy1.68723968
53MP0001968_abnormal_touch/_nociception1.67784960
54MP0003183_abnormal_peptide_metabolism1.67752617
55MP0002396_abnormal_hematopoietic_system1.60260100
56MP0003866_abnormal_defecation1.60025176
57MP0004019_abnormal_vitamin_homeostasis1.58766286
58MP0002735_abnormal_chemical_nociception1.58454560
59MP0009785_altered_susceptibility_to1.58345982
60MP0010234_abnormal_vibrissa_follicle1.55113692
61MP0003091_abnormal_cell_migration1.53041008
62MP0002405_respiratory_system_inflammati1.52774200
63MP0003329_amyloid_beta_deposits1.52289765
64MP0008007_abnormal_cellular_replicative1.51519217
65MP0000716_abnormal_immune_system1.48869774
66MP0003566_abnormal_cell_adhesion1.48430971
67MP0001346_abnormal_lacrimal_gland1.47343533
68MP0000750_abnormal_muscle_regeneration1.46863608
69MP0002796_impaired_skin_barrier1.46471703
70MP0002398_abnormal_bone_marrow1.45920445
71MP0001324_abnormal_eye_pigmentation1.41737315
72MP0001502_abnormal_circadian_rhythm1.39251219
73MP0005389_reproductive_system_phenotype1.38363330
74MP0005464_abnormal_platelet_physiology1.37730333
75MP0003787_abnormal_imprinting1.36711739
76MP0010155_abnormal_intestine_physiology1.36572524
77MP0003448_altered_tumor_morphology1.34633863
78MP0005395_other_phenotype1.33856670
79MP0005551_abnormal_eye_electrophysiolog1.32612564
80MP0000689_abnormal_spleen_morphology1.30420033
81MP0001533_abnormal_skeleton_physiology1.28712781
82MP0000470_abnormal_stomach_morphology1.26846854
83MP0003878_abnormal_ear_physiology1.26426714
84MP0005377_hearing/vestibular/ear_phenot1.26426714
85MP0005076_abnormal_cell_differentiation1.26130787
86MP0005332_abnormal_amino_acid1.24681544
87MP0001845_abnormal_inflammatory_respons1.24456057
88MP0003950_abnormal_plasma_membrane1.23275851
89MP0003632_abnormal_nervous_system1.22674193
90MP0006082_CNS_inflammation1.21883984
91MP0005174_abnormal_tail_pigmentation1.21749984
92MP0004381_abnormal_hair_follicle1.18665163
93MP0004808_abnormal_hematopoietic_stem1.16421031
94MP0002429_abnormal_blood_cell1.15108868
95MP0003453_abnormal_keratinocyte_physiol1.15017120
96MP0002277_abnormal_respiratory_mucosa1.14671081
97MP0002722_abnormal_immune_system1.14610051
98MP0003191_abnormal_cellular_cholesterol1.12537467
99MP0003890_abnormal_embryonic-extraembry1.11209066
100MP0002638_abnormal_pupillary_reflex1.10604512
101MP0000358_abnormal_cell_content/1.10307060
102MP0003763_abnormal_thymus_physiology1.06718918
103MP0005083_abnormal_biliary_tract1.06664514
104MP0005671_abnormal_response_to1.06554253
105MP0000703_abnormal_thymus_morphology1.06425295
106MP0006292_abnormal_olfactory_placode1.05100470
107MP0004742_abnormal_vestibular_system1.03845989
108MP0001661_extended_life_span1.03840023
109MP0002210_abnormal_sex_determination1.03721458
110MP0003690_abnormal_glial_cell1.03431013
111MP0000015_abnormal_ear_pigmentation1.02702634
112MP0005397_hematopoietic_system_phenotyp1.01276598
113MP0001545_abnormal_hematopoietic_system1.01276598
114MP0001929_abnormal_gametogenesis1.00378153
115MP0001958_emphysema0.99706485
116MP0005409_darkened_coat_color0.98775502
117MP0005023_abnormal_wound_healing0.98228602
118MP0000579_abnormal_nail_morphology0.96028347
119MP0001851_eye_inflammation0.95847799
120MP0003786_premature_aging0.95556245
121MP0008932_abnormal_embryonic_tissue0.91459001
122MP0002148_abnormal_hypersensitivity_rea0.91271923
123MP0000538_abnormal_urinary_bladder0.90237126
124MP0006035_abnormal_mitochondrial_morpho0.89822106
125MP0008469_abnormal_protein_level0.89558575
126MP0003656_abnormal_erythrocyte_physiolo0.88963718
127MP0002933_joint_inflammation0.88561581
128MP0001915_intracranial_hemorrhage0.87483613
129MP0001873_stomach_inflammation0.86723027
130MP0004197_abnormal_fetal_growth/weight/0.83730189
131MP0001765_abnormal_ion_homeostasis0.82703885
132MP0004215_abnormal_myocardial_fiber0.81974625
133MP0004185_abnormal_adipocyte_glucose0.81658423
134MP0003705_abnormal_hypodermis_morpholog0.81624169
135MP0000627_abnormal_mammary_gland0.81498519
136MP0005621_abnormal_cell_physiology0.80601155
137MP0003137_abnormal_impulse_conducting0.80458927
138MP0004043_abnormal_pH_regulation0.80119310
139MP0000920_abnormal_myelination0.78944121
140MP0003077_abnormal_cell_cycle0.78155091
141MP0009333_abnormal_splenocyte_physiolog0.77533191
142MP0002928_abnormal_bile_duct0.77209388
143MP0003828_pulmonary_edema0.75142374
144MP0010094_abnormal_chromosome_stability0.74719436
145MP0001145_abnormal_male_reproductive0.73820559
146MP0003699_abnormal_female_reproductive0.72778120
147MP0000653_abnormal_sex_gland0.72144255
148MP0000858_altered_metastatic_potential0.71712091
149MP0010771_integument_phenotype0.70557070
150MP0001853_heart_inflammation0.70325412
151MP0001697_abnormal_embryo_size0.68997670
152MP0005253_abnormal_eye_physiology0.68644246
153MP0005408_hypopigmentation0.68499829
154MP0009764_decreased_sensitivity_to0.68286083
155MP0005365_abnormal_bile_salt0.67203659
156MP0002060_abnormal_skin_morphology0.65499444
157MP0009763_increased_sensitivity_to0.64536258
158MP0001293_anophthalmia0.63437653
159MP0005384_cellular_phenotype0.63397079
160MP0001191_abnormal_skin_condition0.63343002
161MP0000350_abnormal_cell_proliferation0.61570420
162MP0002019_abnormal_tumor_incidence0.61410721
163MP0000367_abnormal_coat/_hair0.60960079
164MP0000490_abnormal_crypts_of0.60730573
165MP0000377_abnormal_hair_follicle0.59576807
166MP0000313_abnormal_cell_death0.59516729
167MP0004264_abnormal_extraembryonic_tissu0.59009743
168MP0000747_muscle_weakness0.58047628
169MP0006036_abnormal_mitochondrial_physio0.58031499
170MP0001672_abnormal_embryogenesis/_devel0.57541232
171MP0005380_embryogenesis_phenotype0.57541232
172MP0010307_abnormal_tumor_latency0.57280374
173MP0002080_prenatal_lethality0.56554910
174MP0008877_abnormal_DNA_methylation0.56024317
175MP0001730_embryonic_growth_arrest0.55940219
176MP0000609_abnormal_liver_physiology0.55620644
177MP0001119_abnormal_female_reproductive0.54959096
178MP0004130_abnormal_muscle_cell0.54848967
179MP0002751_abnormal_autonomic_nervous0.53943353
180MP0005084_abnormal_gallbladder_morpholo0.51345460
181MP0003698_abnormal_male_reproductive0.51210212
182MP0003195_calcinosis0.50560705

Predicted human phenotypes

RankGene SetZ-score
1Testicular atrophy (HP:0000029)6.68709633
2Dyschromatopsia (HP:0007641)6.55721910
3Increased hepatocellular lipid droplets (HP:0006565)5.79826432
4Rib fusion (HP:0000902)5.67580017
5Lipid accumulation in hepatocytes (HP:0006561)5.24864602
6Renal Fanconi syndrome (HP:0001994)5.23965208
7Mesangial abnormality (HP:0001966)5.22378344
8Attenuation of retinal blood vessels (HP:0007843)5.21148612
9Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)5.09125939
10Parakeratosis (HP:0001036)4.79886927
11Elevated erythrocyte sedimentation rate (HP:0003565)4.74599713
12Recurrent abscess formation (HP:0002722)4.59533968
13Decreased electroretinogram (ERG) amplitude (HP:0000654)4.51836878
14Recurrent bacterial skin infections (HP:0005406)4.48077205
15Rectovaginal fistula (HP:0000143)4.40814308
16Rectal fistula (HP:0100590)4.40814308
17Prolonged partial thromboplastin time (HP:0003645)4.39901151
18Stomatitis (HP:0010280)4.17989999
19Popliteal pterygium (HP:0009756)4.13122284
20Exertional dyspnea (HP:0002875)4.12555787
21Facial hemangioma (HP:0000329)4.05407282
22Vaginal fistula (HP:0004320)3.99055028
23Abnormal delayed hypersensitivity skin test (HP:0002963)3.97093135
24Poikiloderma (HP:0001029)3.95088347
25Facial diplegia (HP:0001349)3.90326691
26Intestinal fistula (HP:0100819)3.90097715
27Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.85868428
28Joint hemorrhage (HP:0005261)3.84531746
29Abnormality of the intrinsic pathway (HP:0010989)3.81356979
30Choroideremia (HP:0001139)3.80022123
31Colitis (HP:0002583)3.77740771
32Eczematoid dermatitis (HP:0000976)3.77414314
33Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.72890188
34Decreased central vision (HP:0007663)3.65703440
35Recurrent fungal infections (HP:0002841)3.64727148
36Increased intramyocellular lipid droplets (HP:0012240)3.62414688
37Recurrent viral infections (HP:0004429)3.62117171
38Thin bony cortex (HP:0002753)3.51933143
39Panhypogammaglobulinemia (HP:0003139)3.48464178
40Respiratory difficulties (HP:0002880)3.45998838
41Agammaglobulinemia (HP:0004432)3.43233839
42Chronic mucocutaneous candidiasis (HP:0002728)3.38894023
43Recurrent cutaneous fungal infections (HP:0011370)3.38894023
44Annular pancreas (HP:0001734)3.37314544
45Recurrent skin infections (HP:0001581)3.35572005
46Abnormality of placental membranes (HP:0011409)3.29584475
47Amniotic constriction ring (HP:0009775)3.29584475
48Inflammation of the large intestine (HP:0002037)3.23939499
49Bony spicule pigmentary retinopathy (HP:0007737)3.21776415
50Abnormality of macrophages (HP:0004311)3.21397430
51Aplasia of the musculature (HP:0100854)3.20121068
52Increased muscle lipid content (HP:0009058)3.19949979
53Hemorrhage of the eye (HP:0011885)3.19908086
54Abnormality of renal resorption (HP:0011038)3.18500285
55Birth length less than 3rd percentile (HP:0003561)3.16664966
56Leukocytosis (HP:0001974)3.16185801
57Amyloidosis (HP:0011034)3.13526551
58Akinesia (HP:0002304)3.12940203
59Hypophosphatemic rickets (HP:0004912)3.12214990
60Delayed epiphyseal ossification (HP:0002663)3.11199502
61Pustule (HP:0200039)3.01070074
62Congenital stationary night blindness (HP:0007642)2.98745291
63Patellar aplasia (HP:0006443)2.97725853
64Abnormal urine phosphate concentration (HP:0012599)2.94534767
65Gastrointestinal inflammation (HP:0004386)2.94197533
66Chorioretinal atrophy (HP:0000533)2.87438165
67Squamous cell carcinoma (HP:0002860)2.84757553
68Absent thumb (HP:0009777)2.83688219
69Thyroiditis (HP:0100646)2.80190978
70Abnormal albumin level (HP:0012116)2.78864061
71Hypoalbuminemia (HP:0003073)2.78864061
72Degeneration of the lateral corticospinal tracts (HP:0002314)2.76457284
73Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.76457284
74Recurrent gram-negative bacterial infections (HP:0005420)2.74859217
75Ulnar bowing (HP:0003031)2.74527142
76Myotonia (HP:0002486)2.74071252
77Partial agenesis of the corpus callosum (HP:0001338)2.73203865
78Aplasia/Hypoplasia of the patella (HP:0006498)2.71155126
79Fetal akinesia sequence (HP:0001989)2.66686174
80Sparse lateral eyebrow (HP:0005338)2.66205941
81Prostate neoplasm (HP:0100787)2.66199948
82Capillary hemangiomas (HP:0005306)2.64992885
83Mediastinal lymphadenopathy (HP:0100721)2.57860205
84Choanal stenosis (HP:0000452)2.57142212
85Turricephaly (HP:0000262)2.54904670
86Atrioventricular block (HP:0001678)2.52214504
87Cellulitis (HP:0100658)2.51102690
88Increased cerebral lipofuscin (HP:0011813)2.50948598
89Duplicated collecting system (HP:0000081)2.48835126
90Abnormality of the fingertips (HP:0001211)2.47472011
91Coronal craniosynostosis (HP:0004440)2.45779331
92Lip pit (HP:0100267)2.44662189
93Neonatal onset (HP:0003623)2.42602040
94Vasculitis (HP:0002633)2.41963751
95Abnormality of small intestinal villus morphology (HP:0011472)2.40264927
96Villous atrophy (HP:0011473)2.40264927
97Large earlobe (HP:0009748)2.38934136
98Zonular cataract (HP:0010920)2.37773865
99Meningitis (HP:0001287)2.37268825
100Pendular nystagmus (HP:0012043)2.35394564
101Abnormality of the costochondral junction (HP:0000919)2.33840975
102Absent hand (HP:0004050)2.33272386
103Aplasia/Hypoplasia involving the musculature (HP:0001460)2.33070679
104Osteomyelitis (HP:0002754)2.31543894
105Enlarged epiphyses (HP:0010580)2.31139424
106Combined immunodeficiency (HP:0005387)2.29134428
107Abnormality of the corticospinal tract (HP:0002492)2.27104000
108Widely patent fontanelles and sutures (HP:0004492)2.26056025
109Periodontitis (HP:0000704)2.24941529
110Anteriorly placed anus (HP:0001545)2.24790414
111Gingivitis (HP:0000230)2.23319736
112Abnormality of urine glucose concentration (HP:0011016)2.23032938
113Glycosuria (HP:0003076)2.23032938
114Hyperphosphaturia (HP:0003109)2.22606731
115Pterygium (HP:0001059)2.22103180
116Male infertility (HP:0003251)2.21196820
117Myositis (HP:0100614)2.19427805
118Obstructive lung disease (HP:0006536)2.17210414
119Chronic obstructive pulmonary disease (HP:0006510)2.17210414
120Short chin (HP:0000331)2.16173422
121Increased neuronal autofluorescent lipopigment (HP:0002074)2.16065591
122Thick nail (HP:0001805)2.14584277
123Absent radius (HP:0003974)2.13498905
124Severe combined immunodeficiency (HP:0004430)2.12002639
125Abnormal trabecular bone morphology (HP:0100671)2.11158763
126Neonatal respiratory distress (HP:0002643)2.09835057
127Abnormal epiphyseal ossification (HP:0010656)2.09768740
128Abnormal platelet function (HP:0011869)2.09732577
129Impaired platelet aggregation (HP:0003540)2.09732577
130Basal cell carcinoma (HP:0002671)2.09357556
131Abnormality of the renal collecting system (HP:0004742)2.08517510
132Hematochezia (HP:0002573)2.06896664
133Abnormality of T cell physiology (HP:0011840)2.05519163
134Viral hepatitis (HP:0006562)2.05166639
135Termporal pattern (HP:0011008)2.02917145
136Insidious onset (HP:0003587)2.02917145
137Myocardial infarction (HP:0001658)2.01951523
138Progressive external ophthalmoplegia (HP:0000590)2.01142354
139Renal tubular dysfunction (HP:0000124)2.00667711
140Submucous cleft hard palate (HP:0000176)2.00633229
141Premature graying of hair (HP:0002216)1.99399851
142Hypoplasia of the pons (HP:0012110)1.98873987
143Aplasia involving forearm bones (HP:0009822)1.98027680
144Absent forearm bone (HP:0003953)1.98027680
145Abnormality of the common coagulation pathway (HP:0010990)1.97808054
146Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.96912833
147Abnormality of eosinophils (HP:0001879)1.96780657
148Sepsis (HP:0100806)1.96159881
149Premature loss of primary teeth (HP:0006323)1.95725551
150Gingival bleeding (HP:0000225)1.95134569
151Flat occiput (HP:0005469)1.94952205
152Urticaria (HP:0001025)1.94946990
153Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.92981432
154Macular degeneration (HP:0000608)1.92408484
155Erythroderma (HP:0001019)1.91353861
156Vertebral arch anomaly (HP:0008438)1.91123543
157Azoospermia (HP:0000027)1.90170905
158Prolonged neonatal jaundice (HP:0006579)1.89813088
159Restrictive lung disease (HP:0002091)1.89406903
160Recurrent pneumonia (HP:0006532)1.88421400
161Recurrent lower respiratory tract infections (HP:0002783)1.87353313
162Sensory axonal neuropathy (HP:0003390)1.86357005
163Epiphyseal stippling (HP:0010655)1.86320179
164Abnormality of the pons (HP:0007361)1.84291021
165Encephalitis (HP:0002383)1.84193348
166Vacuolated lymphocytes (HP:0001922)1.83838240
167Chromosomal breakage induced by crosslinking agents (HP:0003221)1.83460417
168Anomalous pulmonary venous return (HP:0010772)1.81701549
169Depressed nasal tip (HP:0000437)1.81600800
170Narrow nasal bridge (HP:0000446)1.81481371
171Diminished movement (HP:0002374)1.81319816
172Interstitial pulmonary disease (HP:0006530)1.81304238
173Long clavicles (HP:0000890)1.80640597
174Onion bulb formation (HP:0003383)1.80632506
175Abolished electroretinogram (ERG) (HP:0000550)1.80591044
176Colon cancer (HP:0003003)1.79996984
177Gastrointestinal stroma tumor (HP:0100723)1.79561743
178Tetraparesis (HP:0002273)1.79009987
179Oral leukoplakia (HP:0002745)1.78875036
180Metaphyseal irregularity (HP:0003025)1.78515907
181Optic neuritis (HP:0100653)1.78118139
182Retrobulbar optic neuritis (HP:0100654)1.78118139
183Short humerus (HP:0005792)1.77898121
184Hyperinsulinemic hypoglycemia (HP:0000825)1.77777335
185Urinary bladder sphincter dysfunction (HP:0002839)1.76964756
186Hypophosphatemia (HP:0002148)1.76337125
187Broad distal phalanx of finger (HP:0009836)1.76284644
188Verrucae (HP:0200043)1.74112205
189Papilloma (HP:0012740)1.74112205
190Orchitis (HP:0100796)1.72084676
191Neuronal loss in central nervous system (HP:0002529)1.71890728
192Type II lissencephaly (HP:0007260)1.71394461
193Flared metaphyses (HP:0003015)1.70735296
194Fused cervical vertebrae (HP:0002949)1.70699432
195Long toe (HP:0010511)1.70681791
196Osteolytic defects of the hand bones (HP:0009699)1.68858294
197Osteolytic defects of the phalanges of the hand (HP:0009771)1.68858294
198Aplasia/hypoplasia of the humerus (HP:0006507)1.68574209
199Abnormality of the hepatic vasculature (HP:0006707)1.68305795
200Low anterior hairline (HP:0000294)1.68236427

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK158.78977701
2BLK5.35176362
3TAOK33.80005213
4BUB13.70685604
5PNCK3.56992212
6DMPK3.44299604
7MUSK3.29314274
8NUAK13.06261209
9BMPR23.05708122
10ACVR1B2.84972571
11MAP3K132.79616978
12MAP4K12.79248710
13MKNK22.78581721
14STK102.69940111
15TAF12.69670559
16MAP3K142.68596001
17WNK42.64885541
18ZAK2.42107717
19TRIM282.31883508
20CDC72.15086532
21RAF12.11210293
22CAMK1G2.08234582
23TESK22.05845294
24EPHB11.84459949
25VRK21.83353370
26TAOK11.79074300
27MOS1.74438846
28FES1.67855605
29STK161.67012009
30ADRBK21.64836216
31PLK11.61202705
32RIPK41.61170754
33TYK21.54187640
34STK241.52407036
35TLK11.48940184
36WNK31.42932342
37ALK1.41107251
38IRAK31.39324079
39LRRK21.37651266
40TBK11.36547871
41CDK191.35900967
42ARAF1.34355238
43SIK21.32651014
44ICK1.31412773
45IRAK41.30798549
46CHEK21.29471702
47IRAK21.27813356
48JAK31.25712706
49BRSK21.25016208
50PLK31.20799297
51SMG11.19670518
52MARK21.17042710
53MAP3K91.16787291
54BMPR1B1.13768642
55CSK1.13659095
56PAK31.13622925
57NEK21.09380565
58ATR1.07420351
59TGFBR11.06544764
60OXSR11.05947003
61IKBKB1.04673220
62KIT1.04224762
63IKBKE1.04095660
64AURKA1.03402149
65EPHA21.02000853
66MKNK11.00277275
67JAK10.97285181
68CDK80.94597541
69MAP3K100.93966954
70KSR20.91992285
71PAK60.91587795
72PBK0.90743920
73TTN0.90623697
74CDK40.90330259
75WNK10.89073108
76ROCK20.88510469
77HCK0.85159552
78GRK60.84731477
79MELK0.83077848
80PKN10.82148647
81CAMK1D0.81376346
82CHUK0.80694692
83PRKCQ0.80583629
84PRKCI0.79646270
85SRPK10.79529272
86MAP2K30.79272182
87MAP3K60.79136584
88CDK150.78780198
89GRK10.75965251
90DYRK20.75413260
91CDK180.74895100
92NME20.74229924
93CDK11A0.72350080
94PTK60.71796921
95FGR0.71080983
96ADRBK10.69118765
97EPHA30.68668057
98TNIK0.67734644
99LCK0.66885938
100MAP3K80.66639316
101ZAP700.65089944
102LATS10.64180441
103PLK40.63396998
104CDK120.61592530
105VRK10.61436745
106STK30.61422900
107FYN0.60956022
108BRAF0.60362755
109CLK10.59879265
110CDK140.59437901
111CSF1R0.57409568
112BRSK10.57258333
113MAPKAPK30.56267442
114SYK0.55351954
115TTK0.55213038
116ERBB40.55203407
117CDC42BPA0.54963649
118MATK0.53645339
119JAK20.53570073
120NEK60.52272322
121ERBB30.51883642
122BMX0.50812356
123ATM0.48907984
124ABL10.48442014
125LYN0.48414719
126CDK60.47145997
127PDPK10.47085988
128PAK10.46701687
129CSNK1A1L0.46646773
130CDK10.46065077
131TSSK60.44944500
132PDK10.44591306
133CDK70.44417750
134TRIB30.43340939
135PTK20.43279085
136CDK20.41537111
137DAPK10.39480643
138DYRK1B0.39237609
139CSNK1G10.38776104
140MAP3K110.38599168
141PRKAA20.38542713
142TIE10.38048963
143ERN10.36326707
144INSRR0.35313587
145MAPKAPK20.34717095
146DYRK30.33934071
147MAP2K60.33244205
148CHEK10.31892234
149BTK0.30732389
150MST40.30720795
151EIF2AK20.30486577
152AURKB0.30308271
153HIPK20.29624647
154STK40.29531921
155MARK30.28050062
156SIK10.27854893
157CSNK1D0.27666249
158NLK0.27525662
159CSNK1G30.27337881
160EGFR0.27220069
161SGK30.27088451
162PAK20.27045749
163STK390.25833915
164MAP3K30.25681441
165MAP3K70.25525699
166ITK0.24697631
167CSNK2A10.23916592
168PRKDC0.23405654
169STK110.23091420

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001307.05405661
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006044.43687319
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.95926609
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.81371473
5Sulfur relay system_Homo sapiens_hsa041223.11854532
6B cell receptor signaling pathway_Homo sapiens_hsa046622.78510290
7NOD-like receptor signaling pathway_Homo sapiens_hsa046212.70482314
8RNA polymerase_Homo sapiens_hsa030202.61548777
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.58028701
10Homologous recombination_Homo sapiens_hsa034402.46710702
11Staphylococcus aureus infection_Homo sapiens_hsa051502.35856387
12Mismatch repair_Homo sapiens_hsa034302.35171790
13DNA replication_Homo sapiens_hsa030302.23706934
14Leishmaniasis_Homo sapiens_hsa051402.20174798
15Osteoclast differentiation_Homo sapiens_hsa043802.14357617
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.13991288
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.08630135
18Basal transcription factors_Homo sapiens_hsa030222.05507172
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.97718394
20Fanconi anemia pathway_Homo sapiens_hsa034601.96445216
21Vitamin digestion and absorption_Homo sapiens_hsa049771.95455548
22Base excision repair_Homo sapiens_hsa034101.92003064
23Malaria_Homo sapiens_hsa051441.88170369
24Cell cycle_Homo sapiens_hsa041101.75842883
25Toxoplasmosis_Homo sapiens_hsa051451.72312741
26TNF signaling pathway_Homo sapiens_hsa046681.72033905
27Pancreatic cancer_Homo sapiens_hsa052121.70332474
28Tuberculosis_Homo sapiens_hsa051521.66483231
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.62120199
30Primary immunodeficiency_Homo sapiens_hsa053401.60798398
31Chronic myeloid leukemia_Homo sapiens_hsa052201.60272188
32Apoptosis_Homo sapiens_hsa042101.58610849
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.57520542
34Small cell lung cancer_Homo sapiens_hsa052221.54358986
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.49290410
36Shigellosis_Homo sapiens_hsa051311.49269351
37T cell receptor signaling pathway_Homo sapiens_hsa046601.48920710
38Non-homologous end-joining_Homo sapiens_hsa034501.43017039
39MicroRNAs in cancer_Homo sapiens_hsa052061.40940345
40Dorso-ventral axis formation_Homo sapiens_hsa043201.40059750
41Toll-like receptor signaling pathway_Homo sapiens_hsa046201.35149710
42Pertussis_Homo sapiens_hsa051331.34274216
43RNA transport_Homo sapiens_hsa030131.33311551
44Proteasome_Homo sapiens_hsa030501.31864197
45Regulation of actin cytoskeleton_Homo sapiens_hsa048101.30391286
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.29025830
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.27948839
48Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.27509914
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.26877621
50RNA degradation_Homo sapiens_hsa030181.24930128
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23903465
52Measles_Homo sapiens_hsa051621.23139778
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22900657
54Hematopoietic cell lineage_Homo sapiens_hsa046401.22467623
55Hepatitis C_Homo sapiens_hsa051601.21871008
56Influenza A_Homo sapiens_hsa051641.20451328
57Renal cell carcinoma_Homo sapiens_hsa052111.19680324
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.18763189
59Caffeine metabolism_Homo sapiens_hsa002321.18387785
60Jak-STAT signaling pathway_Homo sapiens_hsa046301.18132662
61Leukocyte transendothelial migration_Homo sapiens_hsa046701.17011957
62Chemokine signaling pathway_Homo sapiens_hsa040621.14334633
63Antigen processing and presentation_Homo sapiens_hsa046121.12336041
64Hedgehog signaling pathway_Homo sapiens_hsa043401.10809743
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.09841530
66Glycosaminoglycan degradation_Homo sapiens_hsa005311.08878874
67Acute myeloid leukemia_Homo sapiens_hsa052211.08650685
68Other glycan degradation_Homo sapiens_hsa005111.07498617
69Rheumatoid arthritis_Homo sapiens_hsa053231.07157991
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.06755760
71Circadian rhythm_Homo sapiens_hsa047101.06115465
72Fructose and mannose metabolism_Homo sapiens_hsa000511.05740466
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05165959
74Pyrimidine metabolism_Homo sapiens_hsa002401.04452928
75Glutathione metabolism_Homo sapiens_hsa004801.04122231
76Intestinal immune network for IgA production_Homo sapiens_hsa046721.01899365
77Prolactin signaling pathway_Homo sapiens_hsa049170.99798910
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98766112
79Lysosome_Homo sapiens_hsa041420.96586982
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96262121
81Pyruvate metabolism_Homo sapiens_hsa006200.96152713
82Viral myocarditis_Homo sapiens_hsa054160.95506131
83Hepatitis B_Homo sapiens_hsa051610.94772091
84MAPK signaling pathway_Homo sapiens_hsa040100.93724151
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90512785
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90015691
87Amoebiasis_Homo sapiens_hsa051460.88437960
88Steroid biosynthesis_Homo sapiens_hsa001000.87909496
89Proteoglycans in cancer_Homo sapiens_hsa052050.87454932
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87184598
91Purine metabolism_Homo sapiens_hsa002300.86453306
92Salmonella infection_Homo sapiens_hsa051320.86040052
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.83779174
94African trypanosomiasis_Homo sapiens_hsa051430.82210729
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81386344
96Non-small cell lung cancer_Homo sapiens_hsa052230.79918710
97Inositol phosphate metabolism_Homo sapiens_hsa005620.79719473
98Type II diabetes mellitus_Homo sapiens_hsa049300.78320926
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78211909
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.78187258
101VEGF signaling pathway_Homo sapiens_hsa043700.77929568
102Lysine degradation_Homo sapiens_hsa003100.75598283
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75565903
104Taste transduction_Homo sapiens_hsa047420.74526613
105Sphingolipid metabolism_Homo sapiens_hsa006000.74414744
106Chemical carcinogenesis_Homo sapiens_hsa052040.73968451
107Endocytosis_Homo sapiens_hsa041440.71945567
108FoxO signaling pathway_Homo sapiens_hsa040680.71723022
109Nicotine addiction_Homo sapiens_hsa050330.71597481
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71555389
111One carbon pool by folate_Homo sapiens_hsa006700.70583084
112Phototransduction_Homo sapiens_hsa047440.70149491
113Vitamin B6 metabolism_Homo sapiens_hsa007500.70101243
114Histidine metabolism_Homo sapiens_hsa003400.68803068
115Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68761134
116Platelet activation_Homo sapiens_hsa046110.68373008
117Nucleotide excision repair_Homo sapiens_hsa034200.67751844
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.67321232
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66353763
120Phagosome_Homo sapiens_hsa041450.66323360
121Focal adhesion_Homo sapiens_hsa045100.65596146
122Protein export_Homo sapiens_hsa030600.65463890
123Choline metabolism in cancer_Homo sapiens_hsa052310.64869071
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.64716071
125Epstein-Barr virus infection_Homo sapiens_hsa051690.64407542
126Colorectal cancer_Homo sapiens_hsa052100.63565369
127ErbB signaling pathway_Homo sapiens_hsa040120.61626499
128Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59421940
129Notch signaling pathway_Homo sapiens_hsa043300.58787637
130Ovarian steroidogenesis_Homo sapiens_hsa049130.58563777
131Herpes simplex infection_Homo sapiens_hsa051680.58531110
132Complement and coagulation cascades_Homo sapiens_hsa046100.58227810
133Legionellosis_Homo sapiens_hsa051340.57236635
134Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56742541
135Huntingtons disease_Homo sapiens_hsa050160.55842793
136Adipocytokine signaling pathway_Homo sapiens_hsa049200.55502058
137Oxidative phosphorylation_Homo sapiens_hsa001900.54253422
138N-Glycan biosynthesis_Homo sapiens_hsa005100.54144460
139Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53514360
140Hippo signaling pathway_Homo sapiens_hsa043900.52650261
141Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.51743768
142Salivary secretion_Homo sapiens_hsa049700.51370460
143Viral carcinogenesis_Homo sapiens_hsa052030.51036907
144Prostate cancer_Homo sapiens_hsa052150.50860542
145Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50784651
146Fatty acid elongation_Homo sapiens_hsa000620.50123438
147Metabolic pathways_Homo sapiens_hsa011000.49654375
148HTLV-I infection_Homo sapiens_hsa051660.49231721
149Ribosome_Homo sapiens_hsa030100.48737499
150Glycerophospholipid metabolism_Homo sapiens_hsa005640.48690099
151mRNA surveillance pathway_Homo sapiens_hsa030150.48170769
152Selenocompound metabolism_Homo sapiens_hsa004500.48053595
153Basal cell carcinoma_Homo sapiens_hsa052170.47997831
154Parkinsons disease_Homo sapiens_hsa050120.46800614
155Glioma_Homo sapiens_hsa052140.45646539
156Oocyte meiosis_Homo sapiens_hsa041140.45366931
157Pathways in cancer_Homo sapiens_hsa052000.45262012
158p53 signaling pathway_Homo sapiens_hsa041150.44867795
159Ether lipid metabolism_Homo sapiens_hsa005650.44357429
160Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44325428
161Insulin resistance_Homo sapiens_hsa049310.43792246
162Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43657232
163Graft-versus-host disease_Homo sapiens_hsa053320.43341733
164Allograft rejection_Homo sapiens_hsa053300.43265135
165Spliceosome_Homo sapiens_hsa030400.40994680
166Tryptophan metabolism_Homo sapiens_hsa003800.34284331
167Biosynthesis of amino acids_Homo sapiens_hsa012300.32399948
168alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30690603
169Steroid hormone biosynthesis_Homo sapiens_hsa001400.30438700
170Linoleic acid metabolism_Homo sapiens_hsa005910.28632858
171Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.27415003
172Fat digestion and absorption_Homo sapiens_hsa049750.26573383
173Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.24749436
174Thyroid cancer_Homo sapiens_hsa052160.24321912
175Glycerolipid metabolism_Homo sapiens_hsa005610.21860878
176Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19406119
177Mineral absorption_Homo sapiens_hsa049780.19335375
178Nitrogen metabolism_Homo sapiens_hsa009100.17013476
179Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.13978864
180Primary bile acid biosynthesis_Homo sapiens_hsa001200.13951718
181Bladder cancer_Homo sapiens_hsa052190.13946846
182Drug metabolism - other enzymes_Homo sapiens_hsa009830.12328645
183Calcium signaling pathway_Homo sapiens_hsa040200.08923773

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