IL17A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1myeloid dendritic cell differentiation (GO:0043011)9.93042633
2regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)9.68102772
3positive regulation of interleukin-17 production (GO:0032740)8.88653266
4regulation of natural killer cell differentiation (GO:0032823)8.60372137
5regulation of vitamin D biosynthetic process (GO:0060556)8.43735647
6regulation of podosome assembly (GO:0071801)8.40275356
7myeloid dendritic cell activation (GO:0001773)8.26868057
8regulation of interleukin-2 biosynthetic process (GO:0045076)7.93643393
9tyrosine phosphorylation of STAT protein (GO:0007260)7.80327761
10negative regulation of metanephros development (GO:0072217)7.79279580
11positive regulation of interleukin-2 biosynthetic process (GO:0045086)7.55087589
12positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)7.48865833
13positive regulation of natural killer cell mediated immunity (GO:0002717)7.48865833
14regulation of immunoglobulin secretion (GO:0051023)7.40899013
15response to interleukin-15 (GO:0070672)7.38124396
16negative T cell selection (GO:0043383)7.19308474
17positive regulation of chemokine biosynthetic process (GO:0045080)6.94710867
18regulation of vitamin metabolic process (GO:0030656)6.79068889
19regulation of natural killer cell mediated cytotoxicity (GO:0042269)6.66207002
20regulation of natural killer cell mediated immunity (GO:0002715)6.66207002
21regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)6.57715601
22regulation of MHC class II biosynthetic process (GO:0045346)6.45527520
23tolerance induction (GO:0002507)6.42420781
24alpha-beta T cell differentiation (GO:0046632)6.33391978
25negative regulation of interleukin-17 production (GO:0032700)6.32292953
26positive regulation of transcription regulatory region DNA binding (GO:2000679)6.19955099
27alpha-beta T cell activation involved in immune response (GO:0002287)6.04664333
28T cell differentiation involved in immune response (GO:0002292)6.04664333
29alpha-beta T cell differentiation involved in immune response (GO:0002293)6.04664333
30* positive regulation of osteoclast differentiation (GO:0045672)5.98649992
31positive regulation of natural killer cell activation (GO:0032816)5.92236388
32cellular response to interleukin-15 (GO:0071350)5.89012159
33negative thymic T cell selection (GO:0045060)5.83722532
34positive regulation of interferon-gamma biosynthetic process (GO:0045078)5.76023236
35positive regulation of tyrosine phosphorylation of Stat3 protein (GO:0042517)5.75206131
36regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)5.74601109
37positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)5.74601109
38regulation of memory T cell differentiation (GO:0043380)5.69249115
39* regulation of cytokine production involved in inflammatory response (GO:1900015)5.66260140
40positive regulation of inflammatory response to antigenic stimulus (GO:0002863)5.60858100
41positive regulation of leukocyte mediated cytotoxicity (GO:0001912)5.58575969
42dendritic cell differentiation (GO:0097028)5.51253984
43positive regulation of cell fate commitment (GO:0010455)5.41392179
44positive regulation of gamma-delta T cell activation (GO:0046645)5.40389742
45positive regulation of activated T cell proliferation (GO:0042104)5.39192364
46regulation of interleukin-17 production (GO:0032660)5.26427171
47alpha-beta T cell activation (GO:0046631)5.23596123
48negative regulation of thymocyte apoptotic process (GO:0070244)5.22128548
49positive regulation of membrane protein ectodomain proteolysis (GO:0051044)5.21560871
50regulation of chemokine biosynthetic process (GO:0045073)5.19064542
51regulation of isotype switching to IgG isotypes (GO:0048302)5.14914755
52positive regulation of interleukin-12 production (GO:0032735)5.11089777
53leukocyte apoptotic process (GO:0071887)5.06772924
54positive regulation of interleukin-1 beta secretion (GO:0050718)5.03387019
55positive regulation of T cell cytokine production (GO:0002726)5.02439033
56positive regulation of macrophage derived foam cell differentiation (GO:0010744)5.01860025
57regulation of gamma-delta T cell differentiation (GO:0045586)4.97960820
58positive regulation of muscle cell apoptotic process (GO:0010661)4.91295746
59negative regulation of neurological system process (GO:0031645)4.85391616
60regulation of tyrosine phosphorylation of Stat3 protein (GO:0042516)4.84643722
61DNA double-strand break processing (GO:0000729)4.84481157
62positive regulation of cell killing (GO:0031343)4.82128966
63positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.82002076
64positive regulation of interleukin-1 secretion (GO:0050716)4.75174716
65regulation of leukocyte mediated cytotoxicity (GO:0001910)4.75083245
66T-helper 1 type immune response (GO:0042088)4.72348777
67positive regulation of steroid biosynthetic process (GO:0010893)4.70727047
68T cell selection (GO:0045058)4.69353473
69regulation of interleukin-1 beta secretion (GO:0050706)4.61691045
70positive regulation of astrocyte differentiation (GO:0048711)4.60243888
71lung lobe morphogenesis (GO:0060463)4.60049069
72regulation of interferon-gamma biosynthetic process (GO:0045072)4.53157326
73defense response to protozoan (GO:0042832)4.53124630
74positive regulation of interleukin-2 production (GO:0032743)4.45473497
75negative regulation of growth of symbiont in host (GO:0044130)4.44686610
76negative regulation of growth of symbiont involved in interaction with host (GO:0044146)4.44686610
77modulation of growth of symbiont involved in interaction with host (GO:0044144)4.44686610
78regulation of growth of symbiont in host (GO:0044126)4.44686610
79positive regulation of tissue remodeling (GO:0034105)4.44671910
80regulation of nephron tubule epithelial cell differentiation (GO:0072182)4.42764440
81regulation of membrane protein ectodomain proteolysis (GO:0051043)4.42478489
82regulation of smooth muscle cell apoptotic process (GO:0034391)4.42347979
83regulation of gamma-delta T cell activation (GO:0046643)4.40061783
84positive regulation of DNA recombination (GO:0045911)4.40055743
85lung vasculature development (GO:0060426)4.39972077
86muscle organ morphogenesis (GO:0048644)4.39525217
87cytokine biosynthetic process (GO:0042089)4.37490077
88regulation of immunoglobulin production (GO:0002637)4.35863788
89regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033394.35533579
90negative regulation of kidney development (GO:0090185)4.32924812
91signal peptide processing (GO:0006465)4.32329195
92regulation of natural killer cell activation (GO:0032814)4.31854998
93regulation of interleukin-8 biosynthetic process (GO:0045414)4.28488032
94positive regulation of macrophage differentiation (GO:0045651)4.27110185
95regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)4.24780121
96positive regulation of lymphocyte mediated immunity (GO:0002708)4.17125138
97regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.13527504
98regulation of interleukin-1 secretion (GO:0050704)4.13344643
99positive T cell selection (GO:0043368)4.08984042
100regulation of cell killing (GO:0031341)4.08896274
101regulation of interleukin-2 production (GO:0032663)4.08689513
102thymic T cell selection (GO:0045061)4.06903442
103interleukin-1-mediated signaling pathway (GO:0070498)3.97946649
104regulation of epithelial cell differentiation involved in kidney development (GO:2000696)3.94630155
105regulation of interleukin-12 production (GO:0032655)3.91464041
106JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.90593263
107positive regulation of monooxygenase activity (GO:0032770)3.90434752
108regulation of activated T cell proliferation (GO:0046006)3.85067733
109positive regulation of interleukin-1 beta production (GO:0032731)3.84265002
110activated T cell proliferation (GO:0050798)3.82391916
111lactate metabolic process (GO:0006089)3.81683932
112response to protozoan (GO:0001562)3.79713736
113antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.77884279
114positive regulation of cytokine production involved in immune response (GO:0002720)3.75462412
115positive regulation of interleukin-10 production (GO:0032733)3.74590455
116Peyers patch development (GO:0048541)3.69168702
117mucosal-associated lymphoid tissue development (GO:0048537)3.69168702
118CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.62734955
119positive regulation of isotype switching (GO:0045830)3.61330528
120inflammatory response to antigenic stimulus (GO:0002437)3.56009671
121positive regulation of T cell proliferation (GO:0042102)3.55672242
122positive regulation of cytokine biosynthetic process (GO:0042108)3.55543356
123regulation of T-helper cell differentiation (GO:0045622)3.54284309
124positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)3.53956532
125regulation of isotype switching (GO:0045191)3.49673789
126positive regulation of B cell proliferation (GO:0030890)3.49474333
127positive regulation of leukocyte mediated immunity (GO:0002705)3.49094327
128poly(A)+ mRNA export from nucleus (GO:0016973)3.48909533
129regulation of interleukin-10 production (GO:0032653)3.48342968
130regulation of alpha-beta T cell proliferation (GO:0046640)3.47073694
131regulation of lymphocyte mediated immunity (GO:0002706)3.42432612
132cytokine metabolic process (GO:0042107)3.42021396
133positive regulation of interleukin-1 production (GO:0032732)3.36620833
134positive regulation of alcohol biosynthetic process (GO:1902932)3.36112688
135regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.35898029
136regulation of T cell cytokine production (GO:0002724)3.31508210
137positive regulation of organelle assembly (GO:1902117)3.29639228
138negative regulation of erythrocyte differentiation (GO:0045647)3.24886541
139bone resorption (GO:0045453)3.21567190
140positive regulation of B cell activation (GO:0050871)3.20814510
141positive regulation of production of molecular mediator of immune response (GO:0002702)3.20474758
142Notch signaling involved in heart development (GO:0061314)3.17185379
143T cell costimulation (GO:0031295)3.17104751
144endothelial tube morphogenesis (GO:0061154)3.16273126
145morphogenesis of an endothelium (GO:0003159)3.16273126
146regulation of tyrosine phosphorylation of STAT protein (GO:0042509)3.15877230
147positive regulation of defense response to virus by host (GO:0002230)3.15804165
148regulation of inflammatory response to antigenic stimulus (GO:0002861)3.14943020
149positive regulation of alpha-beta T cell proliferation (GO:0046641)3.14275062
150regulation of B cell proliferation (GO:0030888)3.13349055
151lymphocyte costimulation (GO:0031294)3.13287960
152regulation of interleukin-6 biosynthetic process (GO:0045408)3.10431782
153regulation of regulatory T cell differentiation (GO:0045589)3.09852054
154regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.09561790
155positive regulation of cytokine secretion (GO:0050715)3.08382644
156positive regulation of lymphocyte differentiation (GO:0045621)3.08011460
157negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.07027467
158negative regulation of T-helper cell differentiation (GO:0045623)3.07027467
159positive regulation of JAK-STAT cascade (GO:0046427)3.06474230
160growth hormone receptor signaling pathway (GO:0060396)3.05748664
161regulation of thymocyte apoptotic process (GO:0070243)3.05513839
162protein import into nucleus, translocation (GO:0000060)3.01734789
163leukocyte aggregation (GO:0070486)3.00592571
164positive regulation of immunoglobulin mediated immune response (GO:0002891)2.96301909
165positive regulation of B cell mediated immunity (GO:0002714)2.96301909
166regulation of JAK-STAT cascade (GO:0046425)2.95118365
167positive regulation of immunoglobulin production (GO:0002639)2.94276813
168positive regulation of phosphatase activity (GO:0010922)2.91360456
169* positive regulation of myeloid leukocyte differentiation (GO:0002763)2.90284087
170regulation of response to interferon-gamma (GO:0060330)2.86775103
171regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.83646637
172regulation of metanephros development (GO:0072215)2.82048264
173regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.79704646
174regulation of interleukin-12 biosynthetic process (GO:0045075)13.9772639
175positive regulation of natural killer cell differentiation (GO:0032825)13.2761619
176positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)12.4865469

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.88418366
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.17647393
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.01936461
4E2F7_22180533_ChIP-Seq_HELA_Human4.94099137
5STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.33052895
6* PCGF2_27294783_Chip-Seq_ESCs_Mouse4.24293641
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.19597106
8STAT4_19710469_ChIP-ChIP_TH1__Mouse4.04662215
9RUNX_20019798_ChIP-Seq_JUKART_Human3.80840270
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.41894533
11* NFE2_27457419_Chip-Seq_LIVER_Mouse2.90447785
12ZNF274_21170338_ChIP-Seq_K562_Hela2.78124742
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.74086693
14* SUZ12_27294783_Chip-Seq_NPCs_Mouse2.72251815
15MAF_26560356_Chip-Seq_TH1_Human2.49700483
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.40253713
17ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.38416806
18TP63_17297297_ChIP-ChIP_HaCaT_Human2.37737295
19* MYB_26560356_Chip-Seq_TH2_Human2.35100147
20PCGF2_27294783_Chip-Seq_NPCs_Mouse2.32615744
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.23939944
22IRF8_21731497_ChIP-ChIP_J774_Mouse2.23740374
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.18830888
24MYB_26560356_Chip-Seq_TH1_Human2.15782357
25* EZH2_27294783_Chip-Seq_NPCs_Mouse2.14178495
26HTT_18923047_ChIP-ChIP_STHdh_Human2.12297322
27MYC_22102868_ChIP-Seq_BL_Human2.10929357
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse10.3576801
29VDR_21846776_ChIP-Seq_THP-1_Human1.98617438
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.96323921
31HIF1A_21447827_ChIP-Seq_MCF-7_Human1.91241465
32* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.90710739
33* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.88412796
34MAF_26560356_Chip-Seq_TH2_Human1.81261530
35* KLF4_18555785_Chip-Seq_ESCs_Mouse1.80522324
36* CTCF_18555785_Chip-Seq_ESCs_Mouse1.80197728
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.80192038
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.77956396
39GABP_17652178_ChIP-ChIP_JURKAT_Human1.77609276
40* NMYC_18555785_Chip-Seq_ESCs_Mouse1.77425195
41* CRX_20693478_ChIP-Seq_RETINA_Mouse1.76933657
42* P300_18555785_Chip-Seq_ESCs_Mouse1.76691180
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.76237377
44TCF7_22412390_ChIP-Seq_EML_Mouse1.76233807
45* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.75866710
46* SOX2_18555785_Chip-Seq_ESCs_Mouse1.74534609
47DCP1A_22483619_ChIP-Seq_HELA_Human1.74507684
48KDM2B_26808549_Chip-Seq_DND41_Human1.69753339
49* OCT4_18555785_Chip-Seq_ESCs_Mouse1.65883449
50UTX_26944678_Chip-Seq_JUKART_Human1.65804340
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.65003339
52* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.64947082
53IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.63256659
54* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.63182603
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.62828495
56* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.60833856
57VDR_23849224_ChIP-Seq_CD4+_Human1.60520649
58* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.60079369
59VDR_24763502_ChIP-Seq_THP-1_Human1.58691834
60ZNF263_19887448_ChIP-Seq_K562_Human1.58522916
61* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.57513960
62* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.57402646
63ETS1_20019798_ChIP-Seq_JURKAT_Human1.56576790
64* STAT3_18555785_Chip-Seq_ESCs_Mouse1.56389460
65SALL1_21062744_ChIP-ChIP_HESCs_Human1.55809893
66GATA3_27048872_Chip-Seq_THYMUS_Human1.54990398
67* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.53924822
68* E2F1_18555785_Chip-Seq_ESCs_Mouse1.53067556
69ELK1_19687146_ChIP-ChIP_HELA_Human1.50164541
70KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.49608867
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.48955003
72MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.47858189
73STAT3_1855785_ChIP-Seq_MESCs_Mouse1.47043239
74RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46195818
75ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.44742684
76KDM2B_26808549_Chip-Seq_SUP-B15_Human1.43507154
77KDM5A_27292631_Chip-Seq_BREAST_Human1.42398456
78* ZFX_18555785_Chip-Seq_ESCs_Mouse1.41869349
79EST1_17652178_ChIP-ChIP_JURKAT_Human1.37818611
80VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37725326
81* PU1_27457419_Chip-Seq_LIVER_Mouse1.36345966
82NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35819654
83TP63_19390658_ChIP-ChIP_HaCaT_Human1.35483559
84CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.34928999
85JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.34096178
86EGR1_19032775_ChIP-ChIP_M12_Human1.33334666
87THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33182035
88FOXM1_23109430_ChIP-Seq_U2OS_Human1.32814876
89LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32199786
90* CMYC_18555785_Chip-Seq_ESCs_Mouse1.29722966
91* P53_22387025_ChIP-Seq_ESCs_Mouse1.27244820
92TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.26872154
93* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26759528
94KDM2B_26808549_Chip-Seq_JURKAT_Human1.26757518
95IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.21580351
96FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.20946585
97VDR_22108803_ChIP-Seq_LS180_Human1.19861385
98SRF_21415370_ChIP-Seq_HL-1_Mouse1.18244613
99SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17465630
100CLOCK_20551151_ChIP-Seq_293T_Human1.16650248
101BRD4_27068464_Chip-Seq_AML-cells_Mouse1.15771619
102MYB_21317192_ChIP-Seq_ERMYB_Mouse1.15698065
103GATA1_26923725_Chip-Seq_HPCs_Mouse1.12457613
104RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.09004362
105LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.06546762
106FOXO3_23340844_ChIP-Seq_DLD1_Human1.06118084
107SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.04608997
108FOXP3_21729870_ChIP-Seq_TREG_Human1.04471347
109KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03474885
110E2F4_17652178_ChIP-ChIP_JURKAT_Human1.02679355
111* NANOG_18555785_Chip-Seq_ESCs_Mouse1.02635225
112VDR_24787735_ChIP-Seq_THP-1_Human0.97916989
113NOTCH1_21737748_ChIP-Seq_TLL_Human0.96978366
114AR_21572438_ChIP-Seq_LNCaP_Human0.95737955
115IRF8_22096565_ChIP-ChIP_GC-B_Human0.93987437
116STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93699980
117WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93688224
118TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93513213
119RUNX1_22412390_ChIP-Seq_EML_Mouse0.91468751
120ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.88802476
121RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.87557376
122IRF8_27001747_Chip-Seq_BMDM_Mouse0.86622231
123MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.86090816
124HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.86044590
125PU_27001747_Chip-Seq_BMDM_Mouse0.85963032
126* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.84446473
127TP53_22573176_ChIP-Seq_HFKS_Human0.83929785
128SCL_19346495_ChIP-Seq_HPC-7_Human0.83888891
129TRIM28_21343339_ChIP-Seq_HEK293_Human0.82526897
130TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.81679898
131GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.80478298
132CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77687878
133ZFP281_27345836_Chip-Seq_ESCs_Mouse0.77674920
134GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76181098
135E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.76150598
136ELK3_25401928_ChIP-Seq_HUVEC_Human0.75819033
137MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.75635771
138ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.75219436
139* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.75069187
140GATA1_19941826_ChIP-Seq_K562_Human0.74948286
141SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.74788808
142ZFP281_18757296_ChIP-ChIP_E14_Mouse0.74103570
143GATA6_21074721_ChIP-Seq_CACO-2_Human0.73876408
144PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.73872500
145ETV1_20927104_ChIP-Seq_GIST48_Human0.72423743
146YY1_21170310_ChIP-Seq_MESCs_Mouse0.72326695
147TP53_16413492_ChIP-PET_HCT116_Human0.71870906
148PRDM14_20953172_ChIP-Seq_ESCs_Human0.71434255
149SPI1_23127762_ChIP-Seq_K562_Human0.71151811
150GATA3_26560356_Chip-Seq_TH2_Human0.70953691
151FOXA1_27270436_Chip-Seq_PROSTATE_Human0.70645056
152FOXA1_25329375_ChIP-Seq_VCAP_Human0.70645056
153BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.70134469
154CTNNB1_20460455_ChIP-Seq_HCT116_Human0.69646641
155NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.69105029
156FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.68481741
157LXR_22292898_ChIP-Seq_THP-1_Human0.68398057
158* FLI1_27457419_Chip-Seq_LIVER_Mouse0.68313379
159PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.67773059
160BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.67333026
161GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.65002271
162P300_27058665_Chip-Seq_ZR-75-30cells_Human0.64103845
163TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.63203097
164DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.62385752
165GATA3_26560356_Chip-Seq_TH1_Human0.61741178
166SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.60276010
167GATA1_22025678_ChIP-Seq_K562_Human0.59785234
168TP53_22127205_ChIP-Seq_IMR90_Human0.59487437
169NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.59367203
170SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.59083001
171SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.58407082
172SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.58407082
173ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.58295812
174TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.57116056
175UBF1/2_26484160_Chip-Seq_HMECs_Human0.57004867
176KDM2B_26808549_Chip-Seq_K562_Human0.56610396
177TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.56278305
178ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.55264500
179ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.53447657

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001849_ear_inflammation4.57621264
2MP0003300_gastrointestinal_ulcer4.46685415
3MP0003866_abnormal_defecation4.26222152
4MP0003763_abnormal_thymus_physiology4.22872462
5MP0005671_abnormal_response_to4.17962573
6MP0009333_abnormal_splenocyte_physiolog3.42621337
7* MP0002933_joint_inflammation3.40321404
8MP0008875_abnormal_xenobiotic_pharmacok3.38913182
9* MP0003436_decreased_susceptibility_to3.33276170
10MP0001958_emphysema3.32929725
11* MP0001790_abnormal_immune_system3.27056471
12* MP0005387_immune_system_phenotype3.27056471
13MP0000685_abnormal_immune_system3.24176312
14* MP0005000_abnormal_immune_tolerance3.10273092
15MP0010307_abnormal_tumor_latency3.10175401
16* MP0010155_abnormal_intestine_physiology2.75449598
17* MP0001800_abnormal_humoral_immune2.67520945
18MP0001881_abnormal_mammary_gland2.65610055
19MP0005187_abnormal_penis_morphology2.61249199
20MP0005076_abnormal_cell_differentiation2.45198118
21MP0003303_peritoneal_inflammation2.42450694
22MP0002254_reproductive_system_inflammat2.31852847
23* MP0002723_abnormal_immune_serum2.19037922
24* MP0002452_abnormal_antigen_presenting2.18195182
25MP0002396_abnormal_hematopoietic_system2.13428289
26MP0000689_abnormal_spleen_morphology2.05730494
27MP0000703_abnormal_thymus_morphology2.03663574
28* MP0002420_abnormal_adaptive_immunity2.01727580
29MP0004808_abnormal_hematopoietic_stem2.00469528
30MP0002166_altered_tumor_susceptibility1.99731880
31MP0001853_heart_inflammation1.97602987
32MP0002398_abnormal_bone_marrow1.94202600
33MP0010352_gastrointestinal_tract_polyps1.93745932
34MP0002909_abnormal_adrenal_gland1.87132785
35* MP0001819_abnormal_immune_cell1.84816840
36MP0002006_tumorigenesis1.78166235
37* MP0002405_respiratory_system_inflammati1.70094693
38* MP0005025_abnormal_response_to1.67603637
39MP0000627_abnormal_mammary_gland1.62791352
40MP0003448_altered_tumor_morphology1.62543740
41* MP0000716_abnormal_immune_system1.60764458
42* MP0001845_abnormal_inflammatory_respons1.60525076
43* MP0002722_abnormal_immune_system1.57990386
44MP0003567_abnormal_fetal_cardiomyocyte1.55835070
45MP0002095_abnormal_skin_pigmentation1.52519784
46* MP0009785_altered_susceptibility_to1.52396738
47MP0003186_abnormal_redox_activity1.50506902
48MP0001873_stomach_inflammation1.48863702
49MP0005319_abnormal_enzyme/_coenzyme1.48530815
50MP0004782_abnormal_surfactant_physiolog1.45788962
51* MP0002148_abnormal_hypersensitivity_rea1.45386337
52MP0004381_abnormal_hair_follicle1.43831901
53MP0001727_abnormal_embryo_implantation1.42272852
54MP0001529_abnormal_vocalization1.41994211
55MP0001835_abnormal_antigen_presentation1.41860668
56MP0004084_abnormal_cardiac_muscle1.39998059
57MP0005381_digestive/alimentary_phenotyp1.39583562
58MP0005023_abnormal_wound_healing1.36047883
59* MP0002429_abnormal_blood_cell1.32595469
60MP0002419_abnormal_innate_immunity1.26799111
61MP0000490_abnormal_crypts_of1.26227208
62MP0005310_abnormal_salivary_gland1.24560737
63MP0009764_decreased_sensitivity_to1.18260333
64MP0001243_abnormal_dermal_layer1.14097340
65* MP0001533_abnormal_skeleton_physiology1.11636002
66MP0002009_preneoplasia1.11578186
67* MP0008469_abnormal_protein_level1.09904386
68MP0005165_increased_susceptibility_to1.04976920
69MP0000604_amyloidosis1.03561746
70MP0002332_abnormal_exercise_endurance1.03535011
71MP0005646_abnormal_pituitary_gland1.02430216
72MP0008007_abnormal_cellular_replicative0.98413219
73MP0005166_decreased_susceptibility_to0.97237561
74MP0001501_abnormal_sleep_pattern0.97161530
75MP0005501_abnormal_skin_physiology0.96881451
76MP0001764_abnormal_homeostasis0.96803748
77MP0008775_abnormal_heart_ventricle0.95208449
78MP0000647_abnormal_sebaceous_gland0.91218816
79MP0003724_increased_susceptibility_to0.88978159
80MP0003091_abnormal_cell_migration0.88509914
81MP0006082_CNS_inflammation0.88459375
82MP0004947_skin_inflammation0.87056589
83MP0002693_abnormal_pancreas_physiology0.84402434
84MP0001663_abnormal_digestive_system0.82586947
85MP0003705_abnormal_hypodermis_morpholog0.82570593
86MP0002138_abnormal_hepatobiliary_system0.82558674
87MP0000249_abnormal_blood_vessel0.82461190
88MP0005584_abnormal_enzyme/coenzyme_acti0.81747113
89MP0001765_abnormal_ion_homeostasis0.75225319
90MP0008872_abnormal_physiological_respon0.75101350
91* MP0008873_increased_physiological_sensi0.73830338
92MP0005464_abnormal_platelet_physiology0.73611219
93MP0000609_abnormal_liver_physiology0.72709935
94MP0001915_intracranial_hemorrhage0.72709063
95MP0003195_calcinosis0.72553159
96MP0000733_abnormal_muscle_development0.71918784
97MP0002998_abnormal_bone_remodeling0.70219722
98MP0001216_abnormal_epidermal_layer0.69799236
99MP0008770_decreased_survivor_rate0.69786429
100MP0000477_abnormal_intestine_morphology0.69397136
101MP0003075_altered_response_to0.68254603
102MP0008961_abnormal_basal_metabolism0.67493347
103MP0009780_abnormal_chondrocyte_physiolo0.66370917
104MP0000371_diluted_coat_color0.66172189
105MP0000858_altered_metastatic_potential0.64780354
106MP0001545_abnormal_hematopoietic_system0.64272956
107MP0005397_hematopoietic_system_phenotyp0.64272956
108MP0009931_abnormal_skin_appearance0.64032888
109MP0001177_atelectasis0.62866162
110MP0003936_abnormal_reproductive_system0.60804782
111MP0009765_abnormal_xenobiotic_induced0.60430293
112MP0002282_abnormal_trachea_morphology0.59760789
113MP0004134_abnormal_chest_morphology0.59691331
114MP0005365_abnormal_bile_salt0.56518364
115MP0002136_abnormal_kidney_physiology0.56094155
116MP0004510_myositis0.55736091
117MP0002019_abnormal_tumor_incidence0.54915721
118MP0005636_abnormal_mineral_homeostasis0.54774322
119MP0002098_abnormal_vibrissa_morphology0.54207945
120MP0000465_gastrointestinal_hemorrhage0.53502145
121MP0003279_aneurysm0.51990145
122MP0008569_lethality_at_weaning0.51972220
123* MP0005390_skeleton_phenotype0.51589007
124MP0010630_abnormal_cardiac_muscle0.50796880
125MP0001544_abnormal_cardiovascular_syste0.50091108
126MP0005385_cardiovascular_system_phenoty0.50091108
127MP0010234_abnormal_vibrissa_follicle0.49977755
128MP0005551_abnormal_eye_electrophysiolog0.48450345
129MP0001191_abnormal_skin_condition0.47286992
130MP0002086_abnormal_extraembryonic_tissu0.46819750
131MP0001348_abnormal_lacrimal_gland0.46447213
132MP0002088_abnormal_embryonic_growth/wei0.45966675
133MP0000598_abnormal_liver_morphology0.44767655
134MP0003329_amyloid_beta_deposits0.44439022
135MP0000377_abnormal_hair_follicle0.43398777
136MP0002277_abnormal_respiratory_mucosa0.43342023
137MP0004019_abnormal_vitamin_homeostasis0.43245720
138MP0003943_abnormal_hepatobiliary_system0.42819056
139MP0002876_abnormal_thyroid_physiology0.42199594
140MP0001346_abnormal_lacrimal_gland0.40490245
141MP0003699_abnormal_female_reproductive0.37672951

Predicted human phenotypes

RankGene SetZ-score
1Inflammation of the large intestine (HP:0002037)6.99397253
2Gastrointestinal inflammation (HP:0004386)6.77761994
3Recurrent cutaneous fungal infections (HP:0011370)6.41362818
4Chronic mucocutaneous candidiasis (HP:0002728)6.41362818
5Increased hepatocellular lipid droplets (HP:0006565)5.98210066
6IgA deficiency (HP:0002720)5.71495988
7Lipid accumulation in hepatocytes (HP:0006561)5.71227987
8Optic neuritis (HP:0100653)5.55010043
9Retrobulbar optic neuritis (HP:0100654)5.55010043
10Recurrent fungal infections (HP:0002841)5.53545656
11Cheilitis (HP:0100825)5.39931587
12Periodontitis (HP:0000704)5.34228120
13Hemoptysis (HP:0002105)5.29930818
14T lymphocytopenia (HP:0005403)5.05589986
15Orchitis (HP:0100796)4.79126974
16Myositis (HP:0100614)4.78765313
17Increased IgM level (HP:0003496)4.76106496
18Abnormality of T cell number (HP:0011839)4.73903839
19Renal Fanconi syndrome (HP:0001994)4.66913895
20Median cleft lip (HP:0000161)4.33682857
21Pulmonary infiltrates (HP:0002113)4.25798458
22Exertional dyspnea (HP:0002875)4.02439389
23Premature loss of primary teeth (HP:0006323)3.98973461
24Persistence of primary teeth (HP:0006335)3.96485634
25IgM deficiency (HP:0002850)3.84712711
26Autoimmune hemolytic anemia (HP:0001890)3.82826420
27Arterial thrombosis (HP:0004420)3.76126380
2811 pairs of ribs (HP:0000878)3.73646163
29Increased intramyocellular lipid droplets (HP:0012240)3.71736774
30Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.67969352
31Autoimmune thrombocytopenia (HP:0001973)3.64961390
32Scanning speech (HP:0002168)3.62638084
33Esophageal varix (HP:0002040)3.57083392
34Abnormality of T cells (HP:0002843)3.57058493
35Long clavicles (HP:0000890)3.56490960
36Increased density of long bones (HP:0006392)3.56430696
37Keratoconjunctivitis sicca (HP:0001097)3.55956969
38Xerostomia (HP:0000217)3.42330538
39Adactyly (HP:0009776)3.37250470
40Increased muscle lipid content (HP:0009058)3.35326239
41Stomatitis (HP:0010280)3.34828649
42Malignant hyperthermia (HP:0002047)3.31152926
43Recurrent viral infections (HP:0004429)3.29461943
44Nonimmune hydrops fetalis (HP:0001790)3.24469733
45Joint swelling (HP:0001386)3.17572729
46Keratoconjunctivitis (HP:0001096)3.16284555
47Pancreatic islet-cell hyperplasia (HP:0004510)3.05337007
48Respiratory difficulties (HP:0002880)3.02097814
49Metaphyseal cupping (HP:0003021)2.99312372
50Abnormal foot bone ossification (HP:0010675)2.98835090
51Short 4th metacarpal (HP:0010044)2.98733704
52Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.98733704
53Pulmonary embolism (HP:0002204)2.93869484
54Abnormality of the endocardium (HP:0004306)2.92461970
55Gangrene (HP:0100758)2.88333474
56Vasculitis (HP:0002633)2.87702621
57Loss of speech (HP:0002371)2.87563359
58Progressive inability to walk (HP:0002505)2.87242792
59Eczematoid dermatitis (HP:0000976)2.83667925
60Postaxial foot polydactyly (HP:0001830)2.73142110
61Gastrointestinal infarctions (HP:0005244)2.72600688
62Generalized aminoaciduria (HP:0002909)2.71950644
63Thrombophlebitis (HP:0004418)2.71858007
64Recurrent skin infections (HP:0001581)2.71510221
65Abnormality of renal resorption (HP:0011038)2.68091021
66Elevated erythrocyte sedimentation rate (HP:0003565)2.64839430
67Abnormality of the pons (HP:0007361)2.64124243
68Hyperphosphaturia (HP:0003109)2.62905868
69Lower limb hyperreflexia (HP:0002395)2.62659830
70Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.61325422
71Dysmetric saccades (HP:0000641)2.60443693
72Hypoplasia of the pons (HP:0012110)2.60279828
73Panhypogammaglobulinemia (HP:0003139)2.57953574
74Limb hypertonia (HP:0002509)2.56745077
75Absent hand (HP:0004050)2.55385943
76Gastrointestinal stroma tumor (HP:0100723)2.54942899
77Biconcave vertebral bodies (HP:0004586)2.53662611
78Mesomelia (HP:0003027)2.49733262
79Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.47104991
80Abnormality of the fingertips (HP:0001211)2.47095262
81Chest pain (HP:0100749)2.44545732
82Polycythemia (HP:0001901)2.43191608
83Prolonged partial thromboplastin time (HP:0003645)2.42503989
84Abnormality of T cell physiology (HP:0011840)2.40620997
85Increased neuronal autofluorescent lipopigment (HP:0002074)2.40603049
86Arthralgia (HP:0002829)2.40563007
87Toxemia of pregnancy (HP:0100603)2.35703500
88Skull defect (HP:0001362)2.35386027
89Annular pancreas (HP:0001734)2.35227191
90Mild short stature (HP:0003502)2.31178492
91Abnormality of urine glucose concentration (HP:0011016)2.29369530
92Glycosuria (HP:0003076)2.29369530
93Keratitis (HP:0000491)2.27516267
94Neonatal death (HP:0003811)2.26498321
95Mitochondrial inheritance (HP:0001427)2.18529248
96Hepatosplenomegaly (HP:0001433)2.18467766
97Carpal bone hypoplasia (HP:0001498)2.18184129
98Increased CSF lactate (HP:0002490)2.17727858
99Interstitial pulmonary disease (HP:0006530)2.16997812
100Abnormal delayed hypersensitivity skin test (HP:0002963)2.16640963
101Abnormal urine phosphate concentration (HP:0012599)2.14979337
102Portal hypertension (HP:0001409)2.14600880
103Recurrent sinusitis (HP:0011108)2.14451675
104Renal tubular dysfunction (HP:0000124)2.14123343
105Mesangial abnormality (HP:0001966)2.13567610
106Decreased activity of mitochondrial respiratory chain (HP:0008972)2.13506932
107Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.13506932
108Peritonitis (HP:0002586)2.13040325
109Abnormality of the 4th metacarpal (HP:0010012)2.11425088
110Thrombocytosis (HP:0001894)2.09857397
111Inability to walk (HP:0002540)2.09644498
112Glomerulopathy (HP:0100820)2.08464787
113Myocardial infarction (HP:0001658)2.08142986
114Flattened epiphyses (HP:0003071)2.07550011
115Bifid uvula (HP:0000193)2.07164427
116Neutropenia (HP:0001875)2.06168802
117Hypoproteinemia (HP:0003075)2.04841915
118Enlarged epiphyses (HP:0010580)2.03967050
119Polyneuropathy (HP:0001271)2.01529276
120Abnormality of the pleura (HP:0002103)2.01515688
121Abnormality of the hepatic vasculature (HP:0006707)2.00838375
122Abnormality of the prostate (HP:0008775)2.00228254
123Increased cerebral lipofuscin (HP:0011813)2.00154485
124Chronic diarrhea (HP:0002028)11.2882880
125Pruritus (HP:0000989)1.98880970
126Recurrent bronchitis (HP:0002837)1.97131257
127Meningitis (HP:0001287)1.96178856
128Hypothermia (HP:0002045)1.95068989
129Abnormality of the peritoneum (HP:0002585)1.93828133
130Porencephaly (HP:0002132)1.93521542
131Ureteral stenosis (HP:0000071)1.93183836
132Hypoalbuminemia (HP:0003073)1.92185292
133Abnormal albumin level (HP:0012116)1.92185292
134Abnormality of the common coagulation pathway (HP:0010990)1.91383087
135Truncal ataxia (HP:0002078)1.87977245
136Mediastinal lymphadenopathy (HP:0100721)1.87587614
137Abnormality of cells of the lymphoid lineage (HP:0012140)1.86159807
138Gonadal dysgenesis (HP:0000133)1.85751571
139Resting tremor (HP:0002322)1.85636367
140Osteolytic defects of the phalanges of the hand (HP:0009771)1.85372906
141Osteolytic defects of the hand bones (HP:0009699)1.85372906
142Abnormality of the distal phalanges of the toes (HP:0010182)1.84504724
143Fatigue (HP:0012378)1.84167694
144B lymphocytopenia (HP:0010976)1.83640406
145Abnormality of B cell number (HP:0010975)1.83640406
146Macroorchidism (HP:0000053)1.83580414
147Cutis marmorata (HP:0000965)1.82634530
1482-3 toe syndactyly (HP:0004691)1.82434152
149Abnormality of the pericardium (HP:0001697)1.82075824
150Increased IgE level (HP:0003212)1.80258151
151Restrictive lung disease (HP:0002091)1.79578020
152Severe combined immunodeficiency (HP:0004430)1.79361802
153Impaired smooth pursuit (HP:0007772)1.78501915
154Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.77134551
155IgG deficiency (HP:0004315)1.75862032
156Encephalitis (HP:0002383)1.75455715
157Ureteral obstruction (HP:0006000)1.73897647
158Anorexia (HP:0002039)1.72027179
159Cerebral ischemia (HP:0002637)1.70827239
160Acute myeloid leukemia (HP:0004808)1.70569611
161Spontaneous abortion (HP:0005268)1.69546422
162Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.68931301
163Vertigo (HP:0002321)1.64139523
164Absent frontal sinuses (HP:0002688)1.61663140
165Camptodactyly of toe (HP:0001836)1.61548878
166Hematuria (HP:0000790)1.61121904
167Lymphopenia (HP:0001888)1.60749007
168Exercise-induced muscle cramps (HP:0003710)1.59661226
169Skin rash (HP:0000988)1.59540320
170Lymphoma (HP:0002665)1.58887439

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.15372519
2NEK16.40546439
3JAK34.99185224
4ITK4.11274453
5ACVR1B3.97909084
6MAP4K13.70313527
7EPHA33.58409677
8NME12.89370991
9EPHB12.86930906
10FGFR42.80991972
11EEF2K2.76715325
12MST42.47587987
13TNK22.43276281
14EIF2AK32.38146087
15PKN22.24559275
16TEC2.08886160
17MAP3K142.08729782
18MAP2K62.02282922
19CDK121.98390024
20NLK1.97001361
21TRIB31.93920725
22WNK41.93500236
23STK391.90277852
24ZAP701.89890867
25FGFR31.88662171
26TSSK61.88365745
27JAK21.74212233
28LCK1.73934416
29MAP3K121.73633210
30OXSR11.64094715
31BCKDK1.62542617
32CSF1R1.60509947
33TYK21.58000079
34HCK1.53875935
35TTK1.52608572
36PRKD31.51335938
37JAK11.47124969
38EIF2AK11.44093391
39TTN1.43730687
40ALK1.39617207
41PHKG11.39411245
42PHKG21.39411245
43LRRK21.34021223
44VRK11.33368990
45MAP3K71.32277561
46BTK1.24266042
47ADRBK21.22242980
48PRKCQ1.18623054
49PTK61.15682413
50SCYL21.15292429
51FLT31.11843567
52CDK61.08635490
53PLK31.01730590
54PRKCH1.01224748
55PRKG21.00397897
56SIK10.98007276
57TIE10.97043291
58HIPK20.96906043
59EIF2AK20.96834856
60STK100.96765205
61NME20.93121245
62TLK10.90320770
63BRD40.89313372
64RET0.88872398
65SGK30.80899814
66RPS6KA60.80458119
67PAK60.79428082
68IRAK10.79224067
69MAP3K40.78694098
70RPS6KL10.77938939
71RPS6KC10.77938939
72SYK0.77595147
73ERN10.76750612
74PIM20.75688835
75FGFR10.74786123
76TYRO30.73244470
77KSR20.70668511
78CAMK1D0.68406602
79IGF1R0.68064094
80EGFR0.64994323
81CDK40.63790257
82PDK10.62533991
83CAMK1G0.62291168
84MAP3K30.60278882
85BCR0.60037934
86CLK10.58005725
87RIPK10.57337129
88SGK20.55905092
89CHUK0.53306526
90CSNK1D0.52902806
91NTRK20.51896167
92PIM10.50463131
93MAP3K130.50146608
94ATR0.50140487
95CSNK1A1L0.49598180
96NEK90.48484002
97AKT30.47939020
98ROCK20.46489301
99MYLK0.46450471
100CSK0.46258897
101ADRBK10.45494590
102FES0.44238394
103SIK20.42980461
104IKBKB0.42755488
105MAPK40.41669239
106SGK2230.41658561
107SGK4940.41658561
108RPS6KB10.41476293
109GRK60.41084135
110MTOR0.40947264
111CAMKK20.40679400
112RPS6KA50.40587916
113RAF10.40337950
114MAP3K80.39661855
115MAP3K50.39485070
116CDK70.38838663
117MAP2K30.38421289
118WNK10.38230398
119MAPKAPK20.34805246
120MAP3K10.32799407
121KIT0.32773942
122FYN0.30822108
123VRK20.30806598
124CDK150.29459472
125ILK0.29453230
126CDK180.29352602
127PDGFRB0.29331882
128LYN0.27911289
129CDC70.27683051
130MAPK10.27386342
131PRKCB0.27164668
132MARK20.26849370
133CDK11A0.25786753
134ABL10.25639987
135IKBKE0.25304758
136MAP3K20.22580121
137PRKCG0.22424035
138TBK10.21234924
139CDK50.21225491
140PAK20.21072510
141SGK10.21050082
142MAPK30.20709687
143MAPK80.20588227
144ZAK0.20156237
145PASK0.20043418
146ATM0.18835680
147MAPK90.18508818
148CDK30.18451785
149PRKCA0.15995473
150WNK30.13130048
151CSNK2A20.12328524
152CDK140.11178665
153DAPK10.09883571
154CSNK2A10.09405877
155CHEK10.08837276

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002328.23220079
2* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053216.77426507
3Proteasome_Homo sapiens_hsa030505.01402428
4Allograft rejection_Homo sapiens_hsa053304.11227579
5Autoimmune thyroid disease_Homo sapiens_hsa053204.02053811
6Jak-STAT signaling pathway_Homo sapiens_hsa046303.52301987
7Type I diabetes mellitus_Homo sapiens_hsa049403.43631111
8T cell receptor signaling pathway_Homo sapiens_hsa046603.17354802
9Graft-versus-host disease_Homo sapiens_hsa053322.88248855
10Primary immunodeficiency_Homo sapiens_hsa053402.65018643
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.61923012
12Measles_Homo sapiens_hsa051622.30880186
13Regulation of autophagy_Homo sapiens_hsa041402.29088471
14Viral myocarditis_Homo sapiens_hsa054162.28540683
15Asthma_Homo sapiens_hsa053102.19161578
16African trypanosomiasis_Homo sapiens_hsa051432.18788755
17* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040602.06753135
18Protein export_Homo sapiens_hsa030602.05032052
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.71739014
20Hematopoietic cell lineage_Homo sapiens_hsa046401.64119747
21HIF-1 signaling pathway_Homo sapiens_hsa040661.63061160
22Renal cell carcinoma_Homo sapiens_hsa052111.61444606
23Central carbon metabolism in cancer_Homo sapiens_hsa052301.55501885
24Nitrogen metabolism_Homo sapiens_hsa009101.54860449
25Prolactin signaling pathway_Homo sapiens_hsa049171.50592350
26Viral carcinogenesis_Homo sapiens_hsa052031.46772033
27Systemic lupus erythematosus_Homo sapiens_hsa053221.37002676
28Acute myeloid leukemia_Homo sapiens_hsa052211.33488638
29Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.28426795
30Antigen processing and presentation_Homo sapiens_hsa046121.23444330
31Chronic myeloid leukemia_Homo sapiens_hsa052201.22791341
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.18002046
33Osteoclast differentiation_Homo sapiens_hsa043801.06355154
34Homologous recombination_Homo sapiens_hsa034401.05513877
35TNF signaling pathway_Homo sapiens_hsa046681.02969725
36HTLV-I infection_Homo sapiens_hsa051661.00693650
37Fatty acid biosynthesis_Homo sapiens_hsa000611.00453953
38Chemokine signaling pathway_Homo sapiens_hsa040620.98970126
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98334174
40B cell receptor signaling pathway_Homo sapiens_hsa046620.97857590
41mTOR signaling pathway_Homo sapiens_hsa041500.97468321
42Leishmaniasis_Homo sapiens_hsa051400.94556598
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.93799001
44* Rheumatoid arthritis_Homo sapiens_hsa053230.89640069
45Toxoplasmosis_Homo sapiens_hsa051450.89574435
46Hepatitis B_Homo sapiens_hsa051610.89121841
47Propanoate metabolism_Homo sapiens_hsa006400.87882694
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85476694
49Amoebiasis_Homo sapiens_hsa051460.76433824
50MicroRNAs in cancer_Homo sapiens_hsa052060.75160503
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.74675301
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.74625525
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69791648
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.69757675
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67516385
56Dorso-ventral axis formation_Homo sapiens_hsa043200.66949995
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66589997
58Sulfur relay system_Homo sapiens_hsa041220.66524740
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65799430
60Pancreatic cancer_Homo sapiens_hsa052120.63558991
61VEGF signaling pathway_Homo sapiens_hsa043700.62785710
62Phototransduction_Homo sapiens_hsa047440.61515560
63Biosynthesis of amino acids_Homo sapiens_hsa012300.61355471
64Arginine biosynthesis_Homo sapiens_hsa002200.59164238
65Small cell lung cancer_Homo sapiens_hsa052220.58355407
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.55591545
67p53 signaling pathway_Homo sapiens_hsa041150.55479828
68Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.54771325
69Herpes simplex infection_Homo sapiens_hsa051680.54056435
70Epstein-Barr virus infection_Homo sapiens_hsa051690.53710136
71Non-small cell lung cancer_Homo sapiens_hsa052230.52949732
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51768983
73MAPK signaling pathway_Homo sapiens_hsa040100.51135283
74Ether lipid metabolism_Homo sapiens_hsa005650.50942302
75Fanconi anemia pathway_Homo sapiens_hsa034600.50843562
76Glioma_Homo sapiens_hsa052140.50030396
77Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49640671
78Insulin resistance_Homo sapiens_hsa049310.48184630
79Prostate cancer_Homo sapiens_hsa052150.46769417
80One carbon pool by folate_Homo sapiens_hsa006700.46097492
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.45260755
82Staphylococcus aureus infection_Homo sapiens_hsa051500.44897104
83RNA polymerase_Homo sapiens_hsa030200.42896307
84ErbB signaling pathway_Homo sapiens_hsa040120.42036366
85Proteoglycans in cancer_Homo sapiens_hsa052050.41448168
86Type II diabetes mellitus_Homo sapiens_hsa049300.40734414
87Linoleic acid metabolism_Homo sapiens_hsa005910.40635040
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40582891
89Mismatch repair_Homo sapiens_hsa034300.39545833
90Long-term potentiation_Homo sapiens_hsa047200.39316921
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37889593
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37530912
93Shigellosis_Homo sapiens_hsa051310.36838143
94Chemical carcinogenesis_Homo sapiens_hsa052040.36083747
95Nucleotide excision repair_Homo sapiens_hsa034200.35763100
96Lysine degradation_Homo sapiens_hsa003100.35690531
97Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.35084068
98Tuberculosis_Homo sapiens_hsa051520.34689258
99Influenza A_Homo sapiens_hsa051640.34638873
100Notch signaling pathway_Homo sapiens_hsa043300.34412974
101Alcoholism_Homo sapiens_hsa050340.34352802
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.34307084
103Choline metabolism in cancer_Homo sapiens_hsa052310.34003231
104Platelet activation_Homo sapiens_hsa046110.32538602
105Folate biosynthesis_Homo sapiens_hsa007900.32176939
106Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.31857855
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31715911
108Pertussis_Homo sapiens_hsa051330.31402943
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30481751
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.30427422
111NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30349496
112Glucagon signaling pathway_Homo sapiens_hsa049220.29233708
113Apoptosis_Homo sapiens_hsa042100.29109405
114Colorectal cancer_Homo sapiens_hsa052100.28825247
115TGF-beta signaling pathway_Homo sapiens_hsa043500.28172229
116Pathways in cancer_Homo sapiens_hsa052000.27856725
117Basal transcription factors_Homo sapiens_hsa030220.27212512
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.26366939
119Endocytosis_Homo sapiens_hsa041440.26005986
120Cyanoamino acid metabolism_Homo sapiens_hsa004600.25954893
121Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.25433665
122Circadian rhythm_Homo sapiens_hsa047100.24207466
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.24038993
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23467730
125Fructose and mannose metabolism_Homo sapiens_hsa000510.23005825
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.22279413
127Inositol phosphate metabolism_Homo sapiens_hsa005620.22161470
128Toll-like receptor signaling pathway_Homo sapiens_hsa046200.22136206
129Parkinsons disease_Homo sapiens_hsa050120.21726514
130Salmonella infection_Homo sapiens_hsa051320.21173370
131PI3K-Akt signaling pathway_Homo sapiens_hsa041510.20238785
132RNA degradation_Homo sapiens_hsa030180.19971911
133Butanoate metabolism_Homo sapiens_hsa006500.19926318
134Malaria_Homo sapiens_hsa051440.19703974
135Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.19436401
136FoxO signaling pathway_Homo sapiens_hsa040680.19129697
137Phosphatidylinositol signaling system_Homo sapiens_hsa040700.18858592
138Oxidative phosphorylation_Homo sapiens_hsa001900.18055084
139Hepatitis C_Homo sapiens_hsa051600.17490633
140Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.16707069
141Legionellosis_Homo sapiens_hsa051340.15750337
142Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.15304720
143RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.15130651
144Focal adhesion_Homo sapiens_hsa045100.15126208
145Renin secretion_Homo sapiens_hsa049240.14467131
146mRNA surveillance pathway_Homo sapiens_hsa030150.11878326
147Purine metabolism_Homo sapiens_hsa002300.10992214
148Pyrimidine metabolism_Homo sapiens_hsa002400.09673517
149Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.09127296
150Starch and sucrose metabolism_Homo sapiens_hsa005000.08454538
151Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.07273302
152Arachidonic acid metabolism_Homo sapiens_hsa005900.05624168
153Collecting duct acid secretion_Homo sapiens_hsa049660.03306974
154Steroid hormone biosynthesis_Homo sapiens_hsa001400.02578042
155Synaptic vesicle cycle_Homo sapiens_hsa047210.01969343
156Glycerophospholipid metabolism_Homo sapiens_hsa005640.00802799

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