IL11RA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)4.92210757
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.92210757
3activated T cell proliferation (GO:0050798)4.38318975
4negative thymic T cell selection (GO:0045060)3.87083781
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.79161976
6negative regulation of erythrocyte differentiation (GO:0045647)3.76528885
7positive regulation of gamma-delta T cell activation (GO:0046645)3.76421592
8negative T cell selection (GO:0043383)3.76018211
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.54055457
10positive thymic T cell selection (GO:0045059)3.51220491
11thymic T cell selection (GO:0045061)3.37895525
12positive T cell selection (GO:0043368)3.37254940
13tolerance induction (GO:0002507)3.34313686
14antigen processing and presentation of endogenous antigen (GO:0019883)3.31403321
15regulation of gamma-delta T cell differentiation (GO:0045586)3.27926082
16negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.18441623
17T cell selection (GO:0045058)3.17301550
18leukocyte aggregation (GO:0070486)3.14887636
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.14688787
20peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.09962938
21mannose metabolic process (GO:0006013)3.09101251
22regulation of gamma-delta T cell activation (GO:0046643)3.07373928
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.91587828
24regulation of T cell tolerance induction (GO:0002664)2.86454869
25response to laminar fluid shear stress (GO:0034616)2.84070870
26cell migration involved in heart development (GO:0060973)2.82226280
27positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.81791555
28negative regulation of T cell mediated immunity (GO:0002710)2.78607702
29response to interleukin-15 (GO:0070672)2.78425950
30negative regulation of lymphocyte mediated immunity (GO:0002707)2.76912879
31regulation of B cell receptor signaling pathway (GO:0050855)2.72862242
32regulation of ARF GTPase activity (GO:0032312)2.66737669
33regulation of ARF protein signal transduction (GO:0032012)2.64897799
34* head development (GO:0060322)2.63967721
35atrioventricular valve morphogenesis (GO:0003181)2.61261441
36histone H3 deacetylation (GO:0070932)2.54648399
37positive regulation of Rap GTPase activity (GO:0032854)2.54272843
38histone H4 deacetylation (GO:0070933)2.53298948
39response to muramyl dipeptide (GO:0032495)2.53151094
40positive regulation of granulocyte differentiation (GO:0030854)2.50892517
41positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.49117324
42interferon-gamma production (GO:0032609)2.48371349
43modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.48265077
44positive regulation by organism of defense response of other organism involved in symbiotic interact2.48265077
45modulation by symbiont of host immune response (GO:0052553)2.48265077
46positive regulation by symbiont of host defense response (GO:0052509)2.48265077
47modulation by symbiont of host defense response (GO:0052031)2.48265077
48modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.48265077
49detection of bacterium (GO:0016045)2.48100339
50positive regulation of tolerance induction (GO:0002645)2.47097750
51cellular response to epinephrine stimulus (GO:0071872)2.47072281
52negative regulation of leukocyte mediated immunity (GO:0002704)2.46648240
53negative regulation of innate immune response (GO:0045824)2.42986430
54negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.42984217
55regulation of tolerance induction (GO:0002643)2.40841893
56regulation of granulocyte differentiation (GO:0030852)2.38606212
57detection of other organism (GO:0098543)2.37132853
58T cell migration (GO:0072678)2.32524548
59positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.31546727
60actin-myosin filament sliding (GO:0033275)2.30592098
61muscle filament sliding (GO:0030049)2.30592098
62regulation of isotype switching to IgG isotypes (GO:0048302)2.28066301
63positive regulation of CREB transcription factor activity (GO:0032793)2.26447632
64regulation of Rap GTPase activity (GO:0032317)2.24091217
65negative regulation of interleukin-6 production (GO:0032715)2.23425233
66cellular response to interleukin-15 (GO:0071350)2.22965426
67positive regulation of T cell differentiation in thymus (GO:0033089)2.22244168
68cellular response to catecholamine stimulus (GO:0071870)2.21798643
69cellular response to monoamine stimulus (GO:0071868)2.21798643
70cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.21283217
71T cell homeostasis (GO:0043029)2.20007532
72histone H3-K4 trimethylation (GO:0080182)2.18784989
73negative regulation of glycoprotein biosynthetic process (GO:0010561)2.18169633
74negative regulation of cAMP-mediated signaling (GO:0043951)2.18093130
75cardiac myofibril assembly (GO:0055003)2.17842155
76regulation of B cell differentiation (GO:0045577)2.17257826
77histone H3-K9 modification (GO:0061647)2.16870098
78regulation of T cell mediated cytotoxicity (GO:0001914)2.12600002
79fibril organization (GO:0097435)2.11893327
80negative regulation of Ras protein signal transduction (GO:0046580)2.08362422
81regulation of regulatory T cell differentiation (GO:0045589)2.08346398
82negative regulation of small GTPase mediated signal transduction (GO:0051058)2.07553497
83T cell receptor signaling pathway (GO:0050852)2.04515066
84venous blood vessel morphogenesis (GO:0048845)2.04091259
85myofibril assembly (GO:0030239)2.02817412
86regulation of extracellular matrix disassembly (GO:0010715)2.01363953
87negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.00157142
88creatine metabolic process (GO:0006600)1.99196730
89negative regulation of granulocyte differentiation (GO:0030853)1.98854898
90negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)1.98258748
91regulation of glycogen (starch) synthase activity (GO:2000465)1.97703856
92positive regulation of histone deacetylation (GO:0031065)1.97357877
93positive regulation of protein deacetylation (GO:0090312)1.96392713
94keratan sulfate catabolic process (GO:0042340)1.95729169
95parturition (GO:0007567)1.94911853
96extracellular fibril organization (GO:0043206)1.94851973
97respiratory system process (GO:0003016)1.93872861
98negative regulation of type 2 immune response (GO:0002829)1.93772462
99negative regulation of glial cell proliferation (GO:0060253)1.92032542
100positive regulation of myotube differentiation (GO:0010831)1.92024606

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.73845625
2EZH2_22144423_ChIP-Seq_EOC_Human3.10991872
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.87762573
4KDM2B_26808549_Chip-Seq_SUP-B15_Human2.71106985
5KDM2B_26808549_Chip-Seq_DND41_Human2.39572103
6VDR_21846776_ChIP-Seq_THP-1_Human2.21344062
7* LXR_22292898_ChIP-Seq_THP-1_Human2.18074696
8IKZF1_21737484_ChIP-ChIP_HCT116_Human2.06432327
9KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.00444405
10RARG_19884340_ChIP-ChIP_MEFs_Mouse1.99337152
11RUNX_20019798_ChIP-Seq_JUKART_Human1.98451802
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.95402987
13DROSHA_22980978_ChIP-Seq_HELA_Human1.91165588
14VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.90062621
15KDM2B_26808549_Chip-Seq_JURKAT_Human1.89178106
16IRF8_22096565_ChIP-ChIP_GC-B_Human1.88840222
17ELK3_25401928_ChIP-Seq_HUVEC_Human1.85198757
18MAF_26560356_Chip-Seq_TH2_Human1.80115365
19KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.79425564
20TCF7_22412390_ChIP-Seq_EML_Mouse1.79291992
21MAF_26560356_Chip-Seq_TH1_Human1.77829973
22* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.76728603
23KDM2B_26808549_Chip-Seq_K562_Human1.74179451
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.72448598
25CTCF_27219007_Chip-Seq_Bcells_Human1.68226744
26TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68110688
27DNAJC2_21179169_ChIP-ChIP_NT2_Human1.67425721
28UTX_26944678_Chip-Seq_JUKART_Human1.67206088
29BP1_19119308_ChIP-ChIP_Hs578T_Human1.60449216
30EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.57744745
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.56182411
32EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.52846429
33SA1_27219007_Chip-Seq_ERYTHROID_Human1.52810973
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.48518436
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.48159374
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.47629634
37PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.44115845
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.44030370
39MYC_22102868_ChIP-Seq_BL_Human1.43867886
40P68_20966046_ChIP-Seq_HELA_Human1.43484505
41CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.42683896
42GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40874354
43SMC4_20622854_ChIP-Seq_HELA_Human1.40682836
44MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.39457507
45JARID2_20075857_ChIP-Seq_MESCs_Mouse1.37608388
46* BCL6_27268052_Chip-Seq_Bcells_Human1.37482919
47VDR_24763502_ChIP-Seq_THP-1_Human1.37161755
48ZFP281_18757296_ChIP-ChIP_E14_Mouse1.33433196
49CTCF_27219007_Chip-Seq_ERYTHROID_Human1.31728270
50TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30979176
51SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30977239
52RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.30030676
53CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.29437320
54GATA1_19941827_ChIP-Seq_MEL_Mouse1.26460664
55ELF1_20517297_ChIP-Seq_JURKAT_Human1.25496306
56CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.23987867
57EZH2_18974828_ChIP-Seq_MESCs_Mouse1.23520005
58RNF2_18974828_ChIP-Seq_MESCs_Mouse1.23520005
59RNF2_27304074_Chip-Seq_ESCs_Mouse1.23303198
60EZH2_27304074_Chip-Seq_ESCs_Mouse1.21689689
61MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.21574507
62JARID2_20064375_ChIP-Seq_MESCs_Mouse1.17939872
63SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.15450462
64* BCOR_27268052_Chip-Seq_Bcells_Human1.12554944
65ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11703077
66RUNX1_22412390_ChIP-Seq_EML_Mouse1.11628285
67MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.11551776
68SMC1_22415368_ChIP-Seq_MEFs_Mouse1.08364422
69TET1_21451524_ChIP-Seq_MESCs_Mouse1.08129435
70SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08008982
71WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07415551
72CTCF_21964334_ChIP-Seq_BJAB-B_Human1.06101140
73UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05415764
74MTF2_20144788_ChIP-Seq_MESCs_Mouse1.05090617
75IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03831990
76OCT4_19829295_ChIP-Seq_ESCs_Human1.03483287
77SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.03094553
78SMC3_22415368_ChIP-Seq_MEFs_Mouse1.02756075
79SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02626211
80ERG_21242973_ChIP-ChIP_JURKAT_Human1.01973115
81SA1_27219007_Chip-Seq_Bcells_Human1.01099841
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00477971
83NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99344101
84* TP63_22573176_ChIP-Seq_HFKS_Human0.99176524
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98820765
86SPI1_23127762_ChIP-Seq_K562_Human0.98225252
87SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.98057020
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97647318
89SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97258238
90RACK7_27058665_Chip-Seq_MCF-7_Human0.95470922
91SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.94756515
92* CREB1_26743006_Chip-Seq_LNCaP_Human0.94265741
93STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94072227
94TP53_20018659_ChIP-ChIP_R1E_Mouse0.93201042
95OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92167853
96* E2F1_20622854_ChIP-Seq_HELA_Human0.91650262
97SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.90926868
98PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.88178202
99* PHF8_20622854_ChIP-Seq_HELA_Human0.86988826
100RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.86947149

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.06667880
2MP0005503_abnormal_tendon_morphology3.94797700
3MP0005275_abnormal_skin_tensile3.49278502
4MP0003279_aneurysm2.76779786
5MP0003763_abnormal_thymus_physiology2.73402527
6MP0000751_myopathy2.61644070
7MP0003436_decreased_susceptibility_to2.60171860
8MP0001958_emphysema2.31143455
9MP0003724_increased_susceptibility_to2.26944174
10MP0004130_abnormal_muscle_cell2.13027314
11MP0002933_joint_inflammation1.93292691
12MP0009384_cardiac_valve_regurgitation1.91689336
13MP0003828_pulmonary_edema1.68447966
14MP0009278_abnormal_bone_marrow1.67340309
15MP0002108_abnormal_muscle_morphology1.60554587
16MP0001800_abnormal_humoral_immune1.59123922
17MP0001542_abnormal_bone_strength1.54607053
18MP0003122_maternal_imprinting1.52460294
19MP0001986_abnormal_taste_sensitivity1.51200063
20MP0004510_myositis1.46928894
21MP0005377_hearing/vestibular/ear_phenot1.38985649
22MP0003878_abnormal_ear_physiology1.38985649
23MP0002127_abnormal_cardiovascular_syste1.37255859
24MP0005670_abnormal_white_adipose1.36679710
25MP0001851_eye_inflammation1.35647638
26MP0000767_abnormal_smooth_muscle1.34279140
27MP0001533_abnormal_skeleton_physiology1.33971010
28MP0008260_abnormal_autophagy1.30411386
29MP0000750_abnormal_muscle_regeneration1.26055573
30MP0002723_abnormal_immune_serum1.23600809
31MP0000759_abnormal_skeletal_muscle1.23366472
32MP0005387_immune_system_phenotype1.21818669
33MP0001790_abnormal_immune_system1.21818669
34MP0005000_abnormal_immune_tolerance1.21365092
35MP0002106_abnormal_muscle_physiology1.18706127
36MP0002405_respiratory_system_inflammati1.18657924
37MP0005369_muscle_phenotype1.18490230
38MP0002420_abnormal_adaptive_immunity1.17225119
39MP0005390_skeleton_phenotype1.16694333
40MP0003329_amyloid_beta_deposits1.15936139
41MP0001819_abnormal_immune_cell1.15082546
42MP0002419_abnormal_innate_immunity1.13246539
43MP0001348_abnormal_lacrimal_gland1.12038136
44MP0000685_abnormal_immune_system1.11169253
45MP0005423_abnormal_somatic_nervous1.10135231
46MP0005025_abnormal_response_to1.09239651
47MP0008995_early_reproductive_senescence1.07893846
48MP0004036_abnormal_muscle_relaxation1.07536708
49MP0004087_abnormal_muscle_fiber1.06389155
50MP0009333_abnormal_splenocyte_physiolog1.06333443
51MP0000703_abnormal_thymus_morphology1.03009473
52MP0002822_catalepsy1.02458595
53MP0003705_abnormal_hypodermis_morpholog1.01749344
54MP0004145_abnormal_muscle_electrophysio1.01225436
55MP0006138_congestive_heart_failure1.00687764
56MP0002452_abnormal_antigen_presenting0.99228425
57MP0002132_abnormal_respiratory_system0.97364368
58MP0003879_abnormal_hair_cell0.97270665
59MP0004859_abnormal_synaptic_plasticity0.96984741
60MP0005508_abnormal_skeleton_morphology0.95994046
61MP0002998_abnormal_bone_remodeling0.95786252
62MP0003300_gastrointestinal_ulcer0.95204834
63MP0005671_abnormal_response_to0.94035556
64MP0003866_abnormal_defecation0.93349823
65MP0006276_abnormal_autonomic_nervous0.91796344
66MP0004142_abnormal_muscle_tone0.91215455
67MP0004084_abnormal_cardiac_muscle0.89476232
68MP0002138_abnormal_hepatobiliary_system0.89163732
69MP0003303_peritoneal_inflammation0.89085536
70MP0004947_skin_inflammation0.88297247
71MP0002932_abnormal_joint_morphology0.87650528
72MP0001502_abnormal_circadian_rhythm0.86370334
73MP0005666_abnormal_adipose_tissue0.85311799
74MP0001873_stomach_inflammation0.85257966
75MP0005388_respiratory_system_phenotype0.85139123
76MP0002133_abnormal_respiratory_system0.85139123
77MP0000716_abnormal_immune_system0.84801227
78MP0000747_muscle_weakness0.82180534
79MP0005058_abnormal_lysosome_morphology0.80632032
80MP0005535_abnormal_body_temperature0.80499741
81MP0001835_abnormal_antigen_presentation0.79975181
82MP0008569_lethality_at_weaning0.79835812
83MP0004858_abnormal_nervous_system0.79713736
84MP0004883_abnormal_blood_vessel0.78776071
85MP0002249_abnormal_larynx_morphology0.78760155
86MP0005375_adipose_tissue_phenotype0.78220497
87MP0002398_abnormal_bone_marrow0.76741018
88MP0000778_abnormal_nervous_system0.76364405
89MP0003646_muscle_fatigue0.75552447
90MP0005330_cardiomyopathy0.75489653
91MP0001544_abnormal_cardiovascular_syste0.75251878
92MP0005385_cardiovascular_system_phenoty0.75251878
93MP0010630_abnormal_cardiac_muscle0.74059028
94MP0002653_abnormal_ependyma_morphology0.73088410
95MP0002971_abnormal_brown_adipose0.72958618
96MP0000604_amyloidosis0.72869235
97MP0000749_muscle_degeneration0.72683241
98MP0003191_abnormal_cellular_cholesterol0.72493136
99MP0003787_abnormal_imprinting0.72449032
100MP0008004_abnormal_stomach_pH0.72161552

Predicted human phenotypes

RankGene SetZ-score
1Peritonitis (HP:0002586)4.68766556
2Elevated erythrocyte sedimentation rate (HP:0003565)3.79129175
3Protrusio acetabuli (HP:0003179)3.71775661
4Eczematoid dermatitis (HP:0000976)3.52169110
5Aortic dissection (HP:0002647)3.16211134
6Premature rupture of membranes (HP:0001788)3.08962306
7Myositis (HP:0100614)2.96883261
8Gastrointestinal infarctions (HP:0005244)2.90105534
9Asymmetric septal hypertrophy (HP:0001670)2.89521971
10Type 1 muscle fiber predominance (HP:0003803)2.88211586
11Thin bony cortex (HP:0002753)2.85148259
12Ulnar deviation of the wrist (HP:0003049)2.84668541
13Panhypogammaglobulinemia (HP:0003139)2.83667650
14Aortic aneurysm (HP:0004942)2.79976700
15Obstructive sleep apnea (HP:0002870)2.73481438
16Abnormality of the peritoneum (HP:0002585)2.66263169
17Dilatation of the ascending aorta (HP:0005111)2.64323863
18Calcaneovalgus deformity (HP:0001848)2.61715907
19Exercise-induced myalgia (HP:0003738)2.56480515
20Broad metatarsal (HP:0001783)2.54167740
21Anomalous pulmonary venous return (HP:0010772)2.53463182
22Deformed tarsal bones (HP:0008119)2.52619436
23Increased IgE level (HP:0003212)2.51836318
24Joint stiffness (HP:0001387)2.50596203
25Increased variability in muscle fiber diameter (HP:0003557)2.50512031
26Bladder diverticulum (HP:0000015)2.50015111
27Round ear (HP:0100830)2.49914805
28Mitral regurgitation (HP:0001653)2.47231122
29Short 4th metacarpal (HP:0010044)2.46935940
30Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.46935940
31Soft skin (HP:0000977)2.46772856
32Spinal canal stenosis (HP:0003416)2.43445391
33Abnormal delayed hypersensitivity skin test (HP:0002963)2.39368844
34Distal arthrogryposis (HP:0005684)2.35112162
35Spontaneous hematomas (HP:0007420)2.31199647
36Pustule (HP:0200039)2.29907759
37Annular pancreas (HP:0001734)2.28140748
38Dislocated radial head (HP:0003083)2.23918743
39Vascular tortuosity (HP:0004948)2.20698443
40Cerebral aneurysm (HP:0004944)2.20157978
41Abnormality of the aortic arch (HP:0012303)2.17304610
42Infantile muscular hypotonia (HP:0008947)2.16329858
43Orchitis (HP:0100796)2.15012017
44Atrophic scars (HP:0001075)2.13969469
45Hyperlipoproteinemia (HP:0010980)2.13906708
46Abnormality of the pulmonary veins (HP:0011718)2.13764372
47Abnormality of the radial head (HP:0003995)2.12700425
48Genu recurvatum (HP:0002816)2.11603694
49Wide anterior fontanel (HP:0000260)2.08110956
50Abnormality of skeletal muscle fiber size (HP:0012084)2.07935101
51Mitral valve prolapse (HP:0001634)2.07924534
52Biconcave vertebral bodies (HP:0004586)2.07471563
53Hypoplastic ischia (HP:0003175)2.05852457
54Muscle fiber splitting (HP:0003555)2.04812552
55Metaphyseal cupping (HP:0003021)2.04755061
56Joint laxity (HP:0001388)2.03931355
57Abnormality of skull ossification (HP:0002703)2.03908538
58Blue sclerae (HP:0000592)2.03435682
59Shallow orbits (HP:0000586)2.02804375
60Ectopia lentis (HP:0001083)2.02463985
61Gingivitis (HP:0000230)1.99514960
62Colitis (HP:0002583)1.98570011
63Abnormality of the fingertips (HP:0001211)1.98210736
64Abnormality of the lower motor neuron (HP:0002366)1.97111140
65Difficulty running (HP:0009046)1.94658316
66Abnormality of the calcaneus (HP:0008364)1.94476608
67Fragile skin (HP:0001030)1.92728048
68EMG: neuropathic changes (HP:0003445)1.92469553
69Aortic regurgitation (HP:0001659)1.91347407
70Emphysema (HP:0002097)1.90439923
71Optic neuritis (HP:0100653)1.89691344
72Retrobulbar optic neuritis (HP:0100654)1.89691344
73Cervical subluxation (HP:0003308)1.88177144
74Aneurysm (HP:0002617)1.85975074
75Hyporeflexia of lower limbs (HP:0002600)1.83886892
76Recurrent gram-negative bacterial infections (HP:0005420)1.81012389
77Recurrent fungal infections (HP:0002841)1.80066756
78Oligomenorrhea (HP:0000876)1.79862669
79Polyphagia (HP:0002591)1.79309503
80Neoplasm of the heart (HP:0100544)1.78847685
81Broad palm (HP:0001169)1.78628404
82Thin ribs (HP:0000883)1.78513811
83Stomatitis (HP:0010280)1.77407788
84Abnormality of the ischium (HP:0003174)1.77101242
85Striae distensae (HP:0001065)1.76068490
86Arterial tortuosity (HP:0005116)1.75899772
87Hyperextensible skin (HP:0000974)1.75695645
88Abnormality of the humeroradial joint (HP:0100744)1.74474983
89Prolonged bleeding time (HP:0003010)1.72400776
90Increased connective tissue (HP:0009025)1.71844094
91Ankle clonus (HP:0011448)1.69987180
92Mediastinal lymphadenopathy (HP:0100721)1.69931528
93Abnormality of the 4th metacarpal (HP:0010012)1.68446722
94Hypoplasia of the thymus (HP:0000778)1.68139080
95Waddling gait (HP:0002515)1.67395083
96Hip contracture (HP:0003273)1.67268739
97Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.66437019
98Narrow nasal bridge (HP:0000446)1.66088932
99Pulmonary artery stenosis (HP:0004415)1.66018573
100Vitreoretinal degeneration (HP:0000655)1.65410800

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.32607834
2PRPF4B3.13297998
3SIK22.65128226
4MARK22.05037482
5TXK1.94252456
6TRIB31.88646747
7TNK21.87880289
8SIK11.87815406
9EPHB11.87547983
10ZAP701.86212169
11ERN11.83583803
12TYK21.80667708
13DYRK1B1.78256571
14SIK31.72238211
15FES1.65787661
16CDK191.64247733
17MAP3K71.61311837
18MAPK121.50209485
19CAMKK11.47846725
20BLK1.41286971
21RIPK41.36952742
22BTK1.32420166
23CDC42BPA1.29915424
24TTN1.29190173
25NTRK21.29101192
26MAP2K31.26665773
27MAPK71.25674981
28TYRO31.23846606
29FGFR41.19728328
30GRK61.18499616
31EPHA31.17783328
32CAMKK21.16749572
33MAP3K111.16111755
34CSK1.14043567
35JAK31.12758867
36PRKD21.11180421
37IKBKE1.10031291
38MAPK151.08039761
39ITK1.07112344
40HCK1.07022980
41MAP3K61.06201728
42PASK1.04507787
43JAK10.98324222
44MAP3K130.97878064
45KIT0.97077056
46EPHB20.96820023
47STK380.91722507
48RPS6KA20.91308990
49PIK3CG0.89845997
50LCK0.88764487
51SYK0.88718349
52ICK0.87692000
53PRKD30.87248973
54RIPK10.85835905
55RPS6KC10.79197547
56RPS6KL10.79197547
57TBK10.78748836
58UHMK10.78591376
59NLK0.78058060
60OBSCN0.77552820
61MAP3K100.76960113
62MARK30.75990657
63CAMK10.75103196
64SGK4940.74657907
65SGK2230.74657907
66MAP2K20.69594313
67RPS6KA60.69199767
68PRKCH0.68449025
69HIPK20.67903891
70CAMK40.66322407
71DMPK0.65916415
72WNK10.65103130
73PDK10.65094123
74PRKD10.64683264
75FGFR30.64273054
76DYRK1A0.62924450
77JAK20.62717136
78MAP4K20.62568761
79DDR20.61881240
80STK110.60600226
81MARK10.59466401
82TGFBR20.58310500
83SGK30.58008798
84PIK3CA0.57999582
85MAPK40.57663009
86TAOK30.54764365
87SGK20.54616967
88MAP2K40.54127532
89LYN0.52652807
90NEK90.50860746
91PDPK10.50179258
92PDGFRB0.48767165
93PDGFRA0.48481062
94PRKCQ0.47872929
95PTK60.47771294
96IRAK40.47452139
97MAP3K10.46124129
98FYN0.45287609
99PKN20.44997948
100MAP3K30.43920606

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043801.87301717
2T cell receptor signaling pathway_Homo sapiens_hsa046601.78163775
3Primary immunodeficiency_Homo sapiens_hsa053401.73572298
4Other glycan degradation_Homo sapiens_hsa005111.72893741
5Notch signaling pathway_Homo sapiens_hsa043301.71774797
6B cell receptor signaling pathway_Homo sapiens_hsa046621.60668175
7Glycosaminoglycan degradation_Homo sapiens_hsa005311.53690939
8Acute myeloid leukemia_Homo sapiens_hsa052211.50845856
9Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.42251773
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.38074077
11VEGF signaling pathway_Homo sapiens_hsa043701.34852514
12Dilated cardiomyopathy_Homo sapiens_hsa054141.33635193
13Phospholipase D signaling pathway_Homo sapiens_hsa040721.33596089
14Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.28110773
15Neurotrophin signaling pathway_Homo sapiens_hsa047221.24765671
16Choline metabolism in cancer_Homo sapiens_hsa052311.23109324
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.21530628
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.20937319
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.20743680
20Chemokine signaling pathway_Homo sapiens_hsa040621.20012902
21Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.16536910
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.12346580
23Malaria_Homo sapiens_hsa051441.10715574
24MAPK signaling pathway_Homo sapiens_hsa040101.10499112
25GnRH signaling pathway_Homo sapiens_hsa049121.09914701
26Non-small cell lung cancer_Homo sapiens_hsa052231.09863826
27Platelet activation_Homo sapiens_hsa046111.09223506
28Dorso-ventral axis formation_Homo sapiens_hsa043201.08090140
29Staphylococcus aureus infection_Homo sapiens_hsa051501.07418651
30Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05152224
31Colorectal cancer_Homo sapiens_hsa052101.05109499
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.03608074
33Axon guidance_Homo sapiens_hsa043601.03404292
34Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.03049528
35Cholinergic synapse_Homo sapiens_hsa047251.01476372
36Viral myocarditis_Homo sapiens_hsa054160.98760260
37Ras signaling pathway_Homo sapiens_hsa040140.98477739
38Inositol phosphate metabolism_Homo sapiens_hsa005620.97368830
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.94196015
40Vascular smooth muscle contraction_Homo sapiens_hsa042700.93442778
41Oxytocin signaling pathway_Homo sapiens_hsa049210.91928306
42Leishmaniasis_Homo sapiens_hsa051400.90985456
43Adipocytokine signaling pathway_Homo sapiens_hsa049200.90848577
44NF-kappa B signaling pathway_Homo sapiens_hsa040640.90732726
45Insulin resistance_Homo sapiens_hsa049310.90645156
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89557498
47Prolactin signaling pathway_Homo sapiens_hsa049170.88223054
48Endometrial cancer_Homo sapiens_hsa052130.88215504
49Leukocyte transendothelial migration_Homo sapiens_hsa046700.87436634
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.87029935
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.86832857
52Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86459303
53Glycerophospholipid metabolism_Homo sapiens_hsa005640.84957680
54TNF signaling pathway_Homo sapiens_hsa046680.84561907
55Long-term potentiation_Homo sapiens_hsa047200.84312474
56Focal adhesion_Homo sapiens_hsa045100.83388079
57* Jak-STAT signaling pathway_Homo sapiens_hsa046300.82818379
58Endocytosis_Homo sapiens_hsa041440.82414697
59Rap1 signaling pathway_Homo sapiens_hsa040150.81788238
60Renal cell carcinoma_Homo sapiens_hsa052110.80651994
61mTOR signaling pathway_Homo sapiens_hsa041500.80020501
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79210144
63Chronic myeloid leukemia_Homo sapiens_hsa052200.78768580
64Morphine addiction_Homo sapiens_hsa050320.78249418
65Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77971037
66Cocaine addiction_Homo sapiens_hsa050300.74783256
67Toll-like receptor signaling pathway_Homo sapiens_hsa046200.72990636
68Hepatitis B_Homo sapiens_hsa051610.72827505
69Measles_Homo sapiens_hsa051620.72016048
70Circadian entrainment_Homo sapiens_hsa047130.71954793
71Amoebiasis_Homo sapiens_hsa051460.69686985
72Pancreatic cancer_Homo sapiens_hsa052120.68430826
73Toxoplasmosis_Homo sapiens_hsa051450.68166015
74FoxO signaling pathway_Homo sapiens_hsa040680.67690819
75Melanogenesis_Homo sapiens_hsa049160.67179588
76cAMP signaling pathway_Homo sapiens_hsa040240.67168993
77Insulin signaling pathway_Homo sapiens_hsa049100.66454040
78Tuberculosis_Homo sapiens_hsa051520.65747661
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65635242
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65242215
81Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63924670
82Renin secretion_Homo sapiens_hsa049240.63675192
83Autoimmune thyroid disease_Homo sapiens_hsa053200.62495506
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62437064
85Protein digestion and absorption_Homo sapiens_hsa049740.62165841
86Amphetamine addiction_Homo sapiens_hsa050310.60921848
87Calcium signaling pathway_Homo sapiens_hsa040200.60382408
88Complement and coagulation cascades_Homo sapiens_hsa046100.59629302
89AMPK signaling pathway_Homo sapiens_hsa041520.59176392
90ErbB signaling pathway_Homo sapiens_hsa040120.58975754
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58494705
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56773141
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56761435
94Graft-versus-host disease_Homo sapiens_hsa053320.56429235
95Estrogen signaling pathway_Homo sapiens_hsa049150.56090925
96Prion diseases_Homo sapiens_hsa050200.53821911
97HTLV-I infection_Homo sapiens_hsa051660.53656449
98Linoleic acid metabolism_Homo sapiens_hsa005910.52166099
99Gastric acid secretion_Homo sapiens_hsa049710.51625884
100PPAR signaling pathway_Homo sapiens_hsa033200.50919850

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