IKZF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)7.43562339
2positive regulation of gamma-delta T cell activation (GO:0046645)6.11896721
3T cell lineage commitment (GO:0002360)6.08593172
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.76732300
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.76732300
6B cell receptor signaling pathway (GO:0050853)5.68120160
7ribosomal small subunit assembly (GO:0000028)5.08177879
8regulation of regulatory T cell differentiation (GO:0045589)5.07986799
9regulation of isotype switching to IgG isotypes (GO:0048302)4.94821014
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.92410707
11negative T cell selection (GO:0043383)4.86210793
12tolerance induction (GO:0002507)4.79160250
13regulation of T cell tolerance induction (GO:0002664)4.77967558
14B cell homeostasis (GO:0001782)4.75615472
15negative thymic T cell selection (GO:0045060)4.70741126
16antigen processing and presentation of endogenous antigen (GO:0019883)4.68721802
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.60180206
18regulation of gamma-delta T cell differentiation (GO:0045586)4.46256762
19positive regulation of tolerance induction (GO:0002645)4.37221599
20definitive hemopoiesis (GO:0060216)4.30491571
21B cell proliferation (GO:0042100)4.28023383
22interferon-gamma production (GO:0032609)4.27104761
23regulation of gamma-delta T cell activation (GO:0046643)4.23757947
24mast cell activation (GO:0045576)4.17663731
25positive thymic T cell selection (GO:0045059)4.13623625
26negative regulation of T cell mediated immunity (GO:0002710)4.13389862
27positive T cell selection (GO:0043368)4.11977290
28leukocyte aggregation (GO:0070486)4.10202310
29T cell migration (GO:0072678)4.05043197
30T cell selection (GO:0045058)4.03175446
31regulation of tolerance induction (GO:0002643)3.98064002
32T cell homeostasis (GO:0043029)3.94713558
33thymic T cell selection (GO:0045061)3.94108942
34viral transcription (GO:0019083)3.88983968
35positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.77581674
36translational termination (GO:0006415)3.71179428
37response to interleukin-15 (GO:0070672)3.67323438
38cellular response to type I interferon (GO:0071357)3.67226045
39regulation of T cell receptor signaling pathway (GO:0050856)3.65972796
40ribosomal small subunit biogenesis (GO:0042274)3.65378506
41antigen processing and presentation via MHC class Ib (GO:0002475)3.64943562
42cellular response to interleukin-15 (GO:0071350)3.63933005
43negative regulation of B cell proliferation (GO:0030889)3.61790172
44positive regulation by symbiont of host defense response (GO:0052509)3.58511302
45modulation by symbiont of host defense response (GO:0052031)3.58511302
46modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.58511302
47modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.58511302
48positive regulation by organism of defense response of other organism involved in symbiotic interact3.58511302
49modulation by symbiont of host immune response (GO:0052553)3.58511302
50alpha-beta T cell activation (GO:0046631)3.56517979
51T cell receptor signaling pathway (GO:0050852)3.55971701
52T cell differentiation (GO:0030217)3.55567104
53Peyers patch development (GO:0048541)3.54877333
54mucosal-associated lymphoid tissue development (GO:0048537)3.54877333
55megakaryocyte development (GO:0035855)3.54267881
56regulation of B cell proliferation (GO:0030888)3.52645786
57regulation of interleukin-2 biosynthetic process (GO:0045076)3.52079606
58positive regulation of B cell differentiation (GO:0045579)3.47927977
59positive regulation of T cell cytokine production (GO:0002726)3.46474693
60alpha-beta T cell differentiation (GO:0046632)3.45770821
61interferon-gamma-mediated signaling pathway (GO:0060333)3.45694145
62SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.43396706
63histone H3-K4 trimethylation (GO:0080182)3.41206539
64CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.40991945
65positive regulation of humoral immune response (GO:0002922)3.38188131
66cotranslational protein targeting to membrane (GO:0006613)3.37999763
67regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.35893306
68protein targeting to ER (GO:0045047)3.33156707
69myeloid dendritic cell activation (GO:0001773)3.32618224
70response to muramyl dipeptide (GO:0032495)3.28959285
71positive regulation of granulocyte differentiation (GO:0030854)3.28592005
72regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.26723618
73negative regulation of erythrocyte differentiation (GO:0045647)3.20858157
74lymphoid progenitor cell differentiation (GO:0002320)3.20791074
75myeloid dendritic cell differentiation (GO:0043011)3.20755182
76establishment of protein localization to endoplasmic reticulum (GO:0072599)3.19205982
77antigen receptor-mediated signaling pathway (GO:0050851)3.18145784
78mature B cell differentiation (GO:0002335)3.16271048
79regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.14990791
80CD4-positive, alpha-beta T cell activation (GO:0035710)3.13761069
81protein localization to endoplasmic reticulum (GO:0070972)3.13747486
82regulation of interleukin-13 production (GO:0032656)3.13675968
83positive regulation of T cell mediated cytotoxicity (GO:0001916)3.12437524
84positive regulation of B cell proliferation (GO:0030890)3.12185316
85regulation of interleukin-4 production (GO:0032673)3.11177938
86positive regulation of interleukin-4 production (GO:0032753)3.09867349
87regulation of B cell receptor signaling pathway (GO:0050855)3.09772913
88positive regulation of B cell mediated immunity (GO:0002714)3.08626380
89positive regulation of immunoglobulin mediated immune response (GO:0002891)3.08626380
90regulation of alpha-beta T cell proliferation (GO:0046640)3.07986271
91regulation of B cell differentiation (GO:0045577)3.07739197
92translational elongation (GO:0006414)3.06413144
93lymphocyte migration (GO:0072676)3.05743783
94germinal center formation (GO:0002467)3.05421537
95regulation of T cell mediated cytotoxicity (GO:0001914)3.04054088
96positive regulation of alpha-beta T cell proliferation (GO:0046641)3.02165568
97regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.01971635
98positive regulation of interleukin-2 production (GO:0032743)3.01387877
99regulation of isotype switching (GO:0045191)3.00748024
100mast cell activation involved in immune response (GO:0002279)3.00229010
101mast cell degranulation (GO:0043303)3.00229010
102regulation of alpha-beta T cell activation (GO:0046634)2.99794076
103T-helper cell differentiation (GO:0042093)2.98586556
104CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.98586556
105histone H3-K36 demethylation (GO:0070544)2.98287675
106phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.96669622
107negative regulation of cell killing (GO:0031342)2.95583755
108negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.95583755
109positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.94994259
110response to protozoan (GO:0001562)2.94044604
111T cell costimulation (GO:0031295)2.93981612
112lymphocyte homeostasis (GO:0002260)2.93929151
113regulation of protein heterodimerization activity (GO:0043497)2.93757242
114lymphocyte costimulation (GO:0031294)2.93019072
115regulation of B cell activation (GO:0050864)2.92547708
116natural killer cell differentiation (GO:0001779)2.90784044
117T cell activation (GO:0042110)2.89358976
118lymphocyte proliferation (GO:0046651)2.89083279
119positive regulation of developmental pigmentation (GO:0048087)2.89009590
120positive regulation of B cell activation (GO:0050871)2.88912617
121regulation of interleukin-2 production (GO:0032663)2.88159129
122defense response to protozoan (GO:0042832)2.87479096
123lymph node development (GO:0048535)2.87287019
124nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.87087736
125peptidyl-lysine methylation (GO:0018022)2.84825451
126L-fucose metabolic process (GO:0042354)2.84485395
127L-fucose catabolic process (GO:0042355)2.84485395
128fucose catabolic process (GO:0019317)2.84485395
129viral life cycle (GO:0019058)2.84411600
130positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.83982176
131regulation of germinal center formation (GO:0002634)2.83432657
132mononuclear cell proliferation (GO:0032943)2.81956290
133positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.81784824
134regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.79164549
135cytidine metabolic process (GO:0046087)2.77705458
136cytidine catabolic process (GO:0006216)2.77705458
137cytidine deamination (GO:0009972)2.77705458
138cellular protein complex disassembly (GO:0043624)2.76715183
139negative regulation of lymphocyte mediated immunity (GO:0002707)2.76665425
140positive regulation of defense response to virus by host (GO:0002230)2.76473346
141detection of bacterium (GO:0016045)2.76028319
142lymphocyte differentiation (GO:0030098)2.75365191
143response to host immune response (GO:0052572)2.75316180
144response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.75316180
145V(D)J recombination (GO:0033151)2.75254326
146positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.74964506
147leukocyte homeostasis (GO:0001776)2.74585839
148NIK/NF-kappaB signaling (GO:0038061)2.74419749
149regulation of interleukin-12 biosynthetic process (GO:0045075)2.69449027
150response to interferon-beta (GO:0035456)2.68829037
151response to type I interferon (GO:0034340)2.68699807
152negative regulation of adaptive immune response (GO:0002820)2.68410842
153type I interferon signaling pathway (GO:0060337)2.66171930

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.19060667
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.83784780
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.15303256
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.11537142
5E2F7_22180533_ChIP-Seq_HELA_Human4.02033940
6SCL_19346495_ChIP-Seq_HPC-7_Human3.76182968
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.66930860
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.45039149
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.44217802
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.34091796
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.29617730
12STAT4_19710469_ChIP-ChIP_TH1__Mouse3.08513983
13* RUNX_20019798_ChIP-Seq_JUKART_Human3.04639644
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.97409466
15FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.92386791
16MYB_26560356_Chip-Seq_TH2_Human2.91376682
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.88943144
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.82964210
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.75058138
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.66231599
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.52128383
22NOTCH1_21737748_ChIP-Seq_TLL_Human2.50271063
23NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human2.42059096
24SPI1_23547873_ChIP-Seq_NB4_Human2.29762939
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.24055268
26MYB_26560356_Chip-Seq_TH1_Human2.23442239
27FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.20254649
28MYB_21317192_ChIP-Seq_ERMYB_Mouse2.20096667
29MAF_26560356_Chip-Seq_TH1_Human2.15234302
30LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.12890488
31TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.08419388
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.03487340
33UTX_26944678_Chip-Seq_JUKART_Human1.99508448
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.94873318
35HOXB4_20404135_ChIP-ChIP_EML_Mouse1.91754879
36IRF8_21731497_ChIP-ChIP_J774_Mouse1.91674233
37* RUNX1_22412390_ChIP-Seq_EML_Mouse1.88553527
38SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84732562
39NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77644384
40ERG_20887958_ChIP-Seq_HPC-7_Mouse1.77114617
41GATA1_22025678_ChIP-Seq_K562_Human1.76990619
42MYC_22102868_ChIP-Seq_BL_Human1.76810455
43* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.71093848
44SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.69897705
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.68366486
46VDR_21846776_ChIP-Seq_THP-1_Human1.67243526
47FOXM1_23109430_ChIP-Seq_U2OS_Human1.64777012
48RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.64531934
49* GATA3_27048872_Chip-Seq_THYMUS_Human1.60480879
50ELK1_19687146_ChIP-ChIP_HELA_Human1.59046912
51VDR_23849224_ChIP-Seq_CD4+_Human1.58190747
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.56067468
53VDR_24763502_ChIP-Seq_THP-1_Human1.54436863
54IRF8_27001747_Chip-Seq_BMDM_Mouse1.49508259
55GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.45831096
56VDR_24787735_ChIP-Seq_THP-1_Human1.44670341
57FOXP3_21729870_ChIP-Seq_TREG_Human1.42082876
58MAF_26560356_Chip-Seq_TH2_Human1.40720331
59CIITA_25753668_ChIP-Seq_RAJI_Human1.39076093
60* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.36794195
61E2F4_17652178_ChIP-ChIP_JURKAT_Human1.35204934
62* TCF7_22412390_ChIP-Seq_EML_Mouse1.32159457
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31063772
64* PU_27001747_Chip-Seq_BMDM_Mouse1.28890489
65E2F1_21310950_ChIP-Seq_MCF-7_Human1.28732600
66IRF1_19129219_ChIP-ChIP_H3396_Human1.28418584
67GATA3_26560356_Chip-Seq_TH2_Human1.24469384
68GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.21727073
69BRD4_27068464_Chip-Seq_AML-cells_Mouse1.16743047
70TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.16244480
71* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15468077
72GABP_17652178_ChIP-ChIP_JURKAT_Human1.14128361
73* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.11842438
74AR_21572438_ChIP-Seq_LNCaP_Human1.08840788
75Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.04175566
76EST1_17652178_ChIP-ChIP_JURKAT_Human1.03743292
77TP63_19390658_ChIP-ChIP_HaCaT_Human1.03733899
78NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.02612882
79SMAD_19615063_ChIP-ChIP_OVARY_Human1.01187700
80* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.01008126
81SMRT_27268052_Chip-Seq_Bcells_Human1.00469887
82KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.99973941
83* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97800773
84* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.97056213
85SPI1_23127762_ChIP-Seq_K562_Human0.95853679
86E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.95738979
87GATA1_19941827_ChIP-Seq_MEL_Mouse0.92232931
88VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92090723
89MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.89151853
90TP63_17297297_ChIP-ChIP_HaCaT_Human0.89065755
91MYC_18555785_ChIP-Seq_MESCs_Mouse0.88306743
92CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86625503
93GATA3_26560356_Chip-Seq_TH1_Human0.85920045
94PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85122644
95KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.84661745
96* PCGF2_27294783_Chip-Seq_ESCs_Mouse0.84154309
97GATA2_21666600_ChIP-Seq_HMVEC_Human0.84094491
98* FLI1_27457419_Chip-Seq_LIVER_Mouse0.82809496
99CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.82602846
100SRF_21415370_ChIP-Seq_HL-1_Mouse0.82098380
101* PCGF2_27294783_Chip-Seq_NPCs_Mouse0.81728682
102PU.1_20513432_ChIP-Seq_Bcells_Mouse0.80164381
103RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.79836470
104HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.78854009
105CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78730034
106CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.77484454
107CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.77108944
108PKCTHETA_26484144_Chip-Seq_BREAST_Human0.76287401
109PADI4_21655091_ChIP-ChIP_MCF-7_Human0.76032688
110KDM2B_26808549_Chip-Seq_SUP-B15_Human0.75833865
111PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.75314425
112GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74555410
113EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.70583430
114FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69971875
115SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.68519131
116KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.67811857
117PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.66401327
118CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.66332059
119YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.66316257
120STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.66215263
121TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.66038979
122CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.65995658
123VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.65508307
124GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.63778239
125KDM2B_26808549_Chip-Seq_DND41_Human0.62340405
126E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.60056516
127* PRDM14_20953172_ChIP-Seq_ESCs_Human0.59681004

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.80180323
2MP0005671_abnormal_response_to3.83283112
3MP0002396_abnormal_hematopoietic_system3.38234727
4MP0001835_abnormal_antigen_presentation2.97523414
5MP0003724_increased_susceptibility_to2.85247150
6MP0002166_altered_tumor_susceptibility2.77388382
7MP0000685_abnormal_immune_system2.75700307
8MP0000465_gastrointestinal_hemorrhage2.60874474
9MP0001873_stomach_inflammation2.58357137
10MP0001800_abnormal_humoral_immune2.51189166
11MP0002398_abnormal_bone_marrow2.46929568
12* MP0002420_abnormal_adaptive_immunity2.46585579
13MP0009785_altered_susceptibility_to2.45047130
14MP0002148_abnormal_hypersensitivity_rea2.44730912
15* MP0001819_abnormal_immune_cell2.43087828
16MP0005000_abnormal_immune_tolerance2.40791725
17MP0002723_abnormal_immune_serum2.33601519
18MP0001790_abnormal_immune_system2.33416515
19MP0005387_immune_system_phenotype2.33416515
20MP0003866_abnormal_defecation2.26586811
21MP0002006_tumorigenesis2.26493510
22MP0004381_abnormal_hair_follicle2.25026724
23MP0003303_peritoneal_inflammation2.23751501
24MP0002452_abnormal_antigen_presenting2.21027306
25MP0004808_abnormal_hematopoietic_stem2.20626760
26MP0005025_abnormal_response_to2.19303781
27MP0000703_abnormal_thymus_morphology2.18297866
28MP0000716_abnormal_immune_system2.13206562
29MP0005075_abnormal_melanosome_morpholog2.08067726
30MP0010155_abnormal_intestine_physiology2.05895547
31MP0002405_respiratory_system_inflammati2.02626701
32MP0002722_abnormal_immune_system1.99751697
33MP0002009_preneoplasia1.99359183
34MP0009333_abnormal_splenocyte_physiolog1.99238013
35MP0000490_abnormal_crypts_of1.93454676
36MP0005645_abnormal_hypothalamus_physiol1.86842414
37MP0005174_abnormal_tail_pigmentation1.82914497
38MP0003436_decreased_susceptibility_to1.82100422
39MP0005464_abnormal_platelet_physiology1.81384927
40MP0000689_abnormal_spleen_morphology1.81265705
41MP0002419_abnormal_innate_immunity1.81094790
42MP0003045_fibrosis1.80234448
43MP0002429_abnormal_blood_cell1.77917136
44MP0004947_skin_inflammation1.77331435
45MP0005397_hematopoietic_system_phenotyp1.77239747
46MP0001545_abnormal_hematopoietic_system1.77239747
47MP0008007_abnormal_cellular_replicative1.73059750
48MP0002163_abnormal_gland_morphology1.70557215
49MP0002138_abnormal_hepatobiliary_system1.66789180
50MP0001853_heart_inflammation1.61140875
51MP0002877_abnormal_melanocyte_morpholog1.60302028
52MP0001188_hyperpigmentation1.57902428
53MP0005409_darkened_coat_color1.53163980
54MP0001348_abnormal_lacrimal_gland1.51443005
55MP0002277_abnormal_respiratory_mucosa1.45470824
56MP0002132_abnormal_respiratory_system1.42405310
57MP0008057_abnormal_DNA_replication1.39284805
58MP0001845_abnormal_inflammatory_respons1.34891058
59MP0003183_abnormal_peptide_metabolism1.33893356
60MP0002095_abnormal_skin_pigmentation1.33696094
61MP0000383_abnormal_hair_follicle1.24928889
62MP0002933_joint_inflammation1.21466470
63MP0001851_eye_inflammation1.20931164
64MP0005623_abnormal_meninges_morphology1.19929939
65MP0009379_abnormal_foot_pigmentation1.16739533
66MP0000858_altered_metastatic_potential1.16142851
67MP0010307_abnormal_tumor_latency1.15570068
68MP0008058_abnormal_DNA_repair1.10228461
69MP0010094_abnormal_chromosome_stability1.08893699
70MP0003111_abnormal_nucleus_morphology1.06957837
71MP0000569_abnormal_digit_pigmentation1.06200976
72MP0005076_abnormal_cell_differentiation1.05738291
73MP0006082_CNS_inflammation1.03744200
74MP0003300_gastrointestinal_ulcer1.00569907
75MP0001986_abnormal_taste_sensitivity0.98698630
76MP0005310_abnormal_salivary_gland0.98513227
77MP0003091_abnormal_cell_migration0.97408118
78MP0003943_abnormal_hepatobiliary_system0.95680385
79MP0005379_endocrine/exocrine_gland_phen0.93497326
80MP0000371_diluted_coat_color0.92065931
81MP0008961_abnormal_basal_metabolism0.91142205
82MP0000372_irregular_coat_pigmentation0.90944405
83MP0001216_abnormal_epidermal_layer0.90463804
84MP0005220_abnormal_exocrine_pancreas0.89536365
85MP0000350_abnormal_cell_proliferation0.89216439
86MP0002019_abnormal_tumor_incidence0.86959415
87MP0002928_abnormal_bile_duct0.86589464
88MP0005451_abnormal_body_composition0.86238977
89MP0006292_abnormal_olfactory_placode0.85872131
90MP0003693_abnormal_embryo_hatching0.84707846
91MP0003077_abnormal_cell_cycle0.83257648
92MP0008469_abnormal_protein_level0.82944790
93MP0003786_premature_aging0.82908557
94MP0001533_abnormal_skeleton_physiology0.81604261
95MP0001191_abnormal_skin_condition0.81157353
96MP0001346_abnormal_lacrimal_gland0.75427240
97MP0000015_abnormal_ear_pigmentation0.75220693
98MP0002693_abnormal_pancreas_physiology0.73528045
99MP0009765_abnormal_xenobiotic_induced0.71831207
100MP0009115_abnormal_fat_cell0.69404496
101MP0008877_abnormal_DNA_methylation0.67976080
102MP0003941_abnormal_skin_development0.67316752
103MP0009278_abnormal_bone_marrow0.66709958
104MP0002998_abnormal_bone_remodeling0.65161308
105MP0000313_abnormal_cell_death0.64345111
106MP0005621_abnormal_cell_physiology0.63063486
107MP0003315_abnormal_perineum_morphology0.62009632
108MP0002796_impaired_skin_barrier0.61926054
109MP0009931_abnormal_skin_appearance0.60185434
110MP0002098_abnormal_vibrissa_morphology0.59661468
111MP0004145_abnormal_muscle_electrophysio0.59254462
112MP0002060_abnormal_skin_morphology0.58662202
113MP0003252_abnormal_bile_duct0.58467852
114MP0000477_abnormal_intestine_morphology0.57835540
115MP0000377_abnormal_hair_follicle0.57784825
116MP0003828_pulmonary_edema0.57760987
117MP0003448_altered_tumor_morphology0.57374432
118MP0009763_increased_sensitivity_to0.57197845
119MP0003868_abnormal_feces_composition0.56922380
120MP0002168_other_aberrant_phenotype0.56378701
121MP0009764_decreased_sensitivity_to0.56344602
122MP0000367_abnormal_coat/_hair0.55443617
123MP0003567_abnormal_fetal_cardiomyocyte0.55183428
124MP0006054_spinal_hemorrhage0.54945601
125MP0010678_abnormal_skin_adnexa0.52763213
126MP0001663_abnormal_digestive_system0.51739757
127MP0010352_gastrointestinal_tract_polyps0.51699836
128MP0003221_abnormal_cardiomyocyte_apopto0.50825583
129MP0003787_abnormal_imprinting0.50820380
130MP0002102_abnormal_ear_morphology0.49624053
131MP0002136_abnormal_kidney_physiology0.48212806
132MP0008872_abnormal_physiological_respon0.43785354
133MP0000609_abnormal_liver_physiology0.43497206
134MP0005384_cellular_phenotype0.43457751
135MP0002083_premature_death0.39623773

Predicted human phenotypes

RankGene SetZ-score
1IgM deficiency (HP:0002850)5.01555097
2Autoimmune hemolytic anemia (HP:0001890)4.97035093
3Colitis (HP:0002583)4.74618658
4Chronic otitis media (HP:0000389)4.66126213
5T lymphocytopenia (HP:0005403)4.43919937
6Recurrent bronchitis (HP:0002837)4.31465332
7Abnormality of T cell number (HP:0011839)4.27434732
8Myositis (HP:0100614)4.10217846
9Elevated erythrocyte sedimentation rate (HP:0003565)4.08262246
10Abnormality of the fingertips (HP:0001211)3.87133211
11Aplastic anemia (HP:0001915)3.85539212
12Abnormality of T cells (HP:0002843)3.81256147
13Recurrent fungal infections (HP:0002841)3.79122701
14Panhypogammaglobulinemia (HP:0003139)3.72015386
15Abnormal delayed hypersensitivity skin test (HP:0002963)3.69051693
16Recurrent viral infections (HP:0004429)3.63175874
17IgG deficiency (HP:0004315)3.54404524
18Petechiae (HP:0000967)3.49542891
19Viral hepatitis (HP:0006562)3.46165995
20Recurrent cutaneous fungal infections (HP:0011370)3.27797746
21Chronic mucocutaneous candidiasis (HP:0002728)3.27797746
22Abnormality of T cell physiology (HP:0011840)3.21894626
23B lymphocytopenia (HP:0010976)3.20352778
24Abnormality of B cell number (HP:0010975)3.20352778
25Abnormality of cells of the erythroid lineage (HP:0012130)3.19768188
26Abnormal number of erythroid precursors (HP:0012131)3.17862618
27Thrombocytosis (HP:0001894)3.17521631
28Lymphopenia (HP:0001888)3.13486550
29Prolonged bleeding time (HP:0003010)3.10230167
30Basal cell carcinoma (HP:0002671)3.06729341
31Optic neuritis (HP:0100653)3.05784615
32Retrobulbar optic neuritis (HP:0100654)3.05784615
33Emphysema (HP:0002097)2.98803812
34Abnormality of cells of the lymphoid lineage (HP:0012140)2.98500622
35Chronic diarrhea (HP:0002028)2.97968532
36Orchitis (HP:0100796)2.95971749
37Nasal polyposis (HP:0100582)2.95947935
38Lip pit (HP:0100267)2.94743097
39Granulocytopenia (HP:0001913)2.90292481
40Severe combined immunodeficiency (HP:0004430)2.81998788
41Eosinophilia (HP:0001880)2.81632393
42Abnormality of eosinophils (HP:0001879)2.81107196
43Thoracolumbar scoliosis (HP:0002944)2.80404702
44Abnormality of the prostate (HP:0008775)2.80153616
45Verrucae (HP:0200043)2.79513567
46Papilloma (HP:0012740)2.79513567
47Cellulitis (HP:0100658)2.76545350
48Restrictive lung disease (HP:0002091)2.76154452
49Meningitis (HP:0001287)2.70062573
50Recurrent lower respiratory tract infections (HP:0002783)2.69768266
51Reticulocytopenia (HP:0001896)2.69314973
52Bronchitis (HP:0012387)2.64989450
53Eczematoid dermatitis (HP:0000976)2.63762414
54Vasculitis (HP:0002633)2.59739266
55Encephalitis (HP:0002383)2.59413939
56Overlapping toe (HP:0001845)2.57942059
57Acute myeloid leukemia (HP:0004808)2.52294812
58Hypoplasia of the thymus (HP:0000778)2.51635504
59Increased IgE level (HP:0003212)2.51326474
60IgA deficiency (HP:0002720)2.49512221
61Lymphoma (HP:0002665)2.47954180
62Leukocytosis (HP:0001974)2.47790821
63Chin dimple (HP:0010751)2.45694822
64Recurrent abscess formation (HP:0002722)2.45001977
65Hepatitis (HP:0012115)2.44800217
66Agammaglobulinemia (HP:0004432)2.39431156
6711 pairs of ribs (HP:0000878)2.37268167
68Pulmonary infiltrates (HP:0002113)2.35633211
69Abnormality of the nasal mucosa (HP:0000433)2.34110203
70Type 2 muscle fiber atrophy (HP:0003554)2.34003153
71Combined immunodeficiency (HP:0005387)2.29972737
72Epistaxis (HP:0000421)2.28392428
73Recurrent sinusitis (HP:0011108)2.27064556
74Papilledema (HP:0001085)2.23687680
75Keratoconjunctivitis sicca (HP:0001097)2.23468394
76Recurrent pneumonia (HP:0006532)2.23396592
77Hemoptysis (HP:0002105)2.22936821
78Prominent nose (HP:0000448)2.22123819
79Muscle fiber atrophy (HP:0100295)2.20701860
80Pustule (HP:0200039)2.20485802
81Absent rod-and cone-mediated responses on ERG (HP:0007688)2.19130822
82Hypergammaglobulinemia (HP:0010702)2.18273313
83Aplasia/Hypoplasia of the thymus (HP:0010515)2.17440470
84Leukopenia (HP:0001882)2.17337436
85Recurrent otitis media (HP:0000403)2.17275446
86Recurrent skin infections (HP:0001581)2.17164209
87Menstrual irregularities (HP:0000858)2.16803986
88Autoimmune thrombocytopenia (HP:0001973)2.16721656
89Osteomyelitis (HP:0002754)2.15147900
90Abnormality of the columella (HP:0009929)2.14348620
91Acute hepatic failure (HP:0006554)2.13527701
92Myelodysplasia (HP:0002863)2.13462289
93Squamous cell carcinoma (HP:0002860)2.13448178
94Fatigue (HP:0012378)2.13275345
95Broad face (HP:0000283)2.12666195
96Pallor (HP:0000980)2.12484544
97Sparse scalp hair (HP:0002209)2.11552621
98Abnormality of small intestinal villus morphology (HP:0011472)2.09946858
99Villous atrophy (HP:0011473)2.09946858
100Erythema (HP:0010783)2.07010067
101Chronic sinusitis (HP:0011109)2.05394585
102Inflammation of the large intestine (HP:0002037)2.04978574
103Weak cry (HP:0001612)2.03638707
104Thyroiditis (HP:0100646)2.01263173
105Abnormality of the pleura (HP:0002103)2.00643327
106Amaurosis fugax (HP:0100576)1.99995360
107Obstructive lung disease (HP:0006536)1.99921818
108Chronic obstructive pulmonary disease (HP:0006510)1.99921818
109Keratoconjunctivitis (HP:0001096)1.99727913
110Hypothermia (HP:0002045)1.99090130
111Volvulus (HP:0002580)1.99076315
112Bronchiectasis (HP:0002110)1.97026238
113Acute lymphatic leukemia (HP:0006721)1.95522332
114Gastrointestinal stroma tumor (HP:0100723)1.95331416
115Joint swelling (HP:0001386)1.94131510
116Neutropenia (HP:0001875)1.91622462
117Chronic hepatic failure (HP:0100626)1.89612578
118Type I transferrin isoform profile (HP:0003642)1.89403274
119Stomatitis (HP:0010280)1.89322300
120Recurrent bacterial skin infections (HP:0005406)1.88220000
121Abnormal pancreas size (HP:0012094)1.87720851
122Cheilitis (HP:0100825)1.86805601
123Gastrointestinal inflammation (HP:0004386)1.86482347
124Abnormal hair whorl (HP:0010721)1.86283430
125Arterial thrombosis (HP:0004420)1.85826985
126Mediastinal lymphadenopathy (HP:0100721)1.85600921
127Xerostomia (HP:0000217)1.83962491
128Slow saccadic eye movements (HP:0000514)1.83904285
129Purpura (HP:0000979)1.83873009
130Increased IgM level (HP:0003496)1.83428729
131Ectropion (HP:0000656)1.83421540
132Carpal bone hypoplasia (HP:0001498)1.82575224
133Pancytopenia (HP:0001876)1.81407786
134Gangrene (HP:0100758)1.80176845
135Sepsis (HP:0100806)1.78956470
136Abnormality of the thymus (HP:0000777)1.76811464
137Dysmetric saccades (HP:0000641)1.75098368
138Abnormality of the peritoneum (HP:0002585)1.74363028
139Spontaneous hematomas (HP:0007420)1.73931763
140Submucous cleft hard palate (HP:0000176)1.73210035

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.72501110
2MAP4K14.17722989
3PRPF4B3.76055228
4RIPK43.51603812
5EIF2AK32.86608769
6KIT2.65778438
7TEC2.55501029
8IKBKE2.54828177
9JAK32.51817177
10ZAP702.34864468
11MAP3K102.32211357
12IRAK42.18887208
13TNIK2.18546440
14NLK2.12176168
15CDK122.11167008
16ITK2.05647613
17BTK2.03300532
18FGFR41.93278115
19SMG11.91929325
20TYK21.91499257
21MAP3K141.88852059
22STK101.79954337
23TAOK31.79065317
24NME21.78983011
25MST41.76726525
26LCK1.72224707
27PIM21.66873376
28BMPR21.62768870
29FGFR31.56706997
30FRK1.53504712
31NEK91.39412518
32CLK11.38230452
33MELK1.36592761
34JAK11.35491040
35SYK1.35038690
36TNK21.33148024
37TBK11.31368203
38TGFBR11.28821569
39TAF11.25376939
40IKBKB1.22484034
41VRK11.16977345
42PIM11.13313142
43EPHA31.12043899
44BMPR1B1.10666920
45STK241.05700606
46HCK1.05037918
47IRAK11.03627555
48FLT31.02082083
49SIK31.00827436
50MAP3K120.98602481
51STK160.98233917
52HIPK20.97728879
53PRKCH0.97318510
54MAPK70.96688327
55RPS6KB20.96541725
56LYN0.90166422
57TRPM70.89144365
58IRAK30.87986438
59SGK20.87350128
60CSF1R0.86843820
61SRPK10.85751982
62NEK60.84231395
63MAPKAPK50.83173983
64MAPK150.80819361
65MKNK10.80817556
66STK40.80363798
67EEF2K0.80308430
68PRKCQ0.78606218
69WNK10.77913729
70KDR0.77576042
71PIK3CG0.77479579
72YES10.77152161
73CDC70.74466687
74CDK60.73729578
75ZAK0.72916257
76CHUK0.71595141
77FES0.71201327
78RPS6KA50.71172254
79TGFBR20.70612066
80TLK10.69359549
81BRD40.68115348
82CDC42BPA0.67510890
83PASK0.67453260
84CDK80.67309937
85NME10.65447302
86CAMKK10.65028720
87BLK0.64215718
88JAK20.63649769
89DYRK30.63394810
90CAMKK20.63346377
91MUSK0.63230341
92GRK60.62707899
93LRRK20.61506028
94MAPK120.60295339
95MKNK20.60207323
96CSK0.59961208
97RPS6KA40.58460685
98MAP2K30.56300937
99CDK70.56100752
100STK38L0.55248191
101RPS6KA60.53570876
102ATR0.52795823
103MAP3K130.52427749
104SGK30.51704908
105PDK10.51498911
106CDK40.49297946
107SIK20.49076033
108MAPK40.48592737
109NUAK10.48542511
110MAP3K70.47484045
111MAPKAPK30.47409323
112EIF2AK20.45365509
113CDK90.44394054
114IRAK20.42896332
115CCNB10.42777309
116PIK3CA0.42593330
117MAPK110.40552253
118MARK30.39190590
119MAP3K50.38720738
120CHEK10.38112215
121MAPK130.36852176
122MAPKAPK20.36325423
123CDK30.36156755
124RPS6KC10.36054711
125RPS6KL10.36054711
126EPHB10.35892944
127MATK0.35123544
128ADRBK20.34587185
129MAPK30.34218889
130ATM0.31502989
131PKN20.29724034
132BCR0.28279775
133STK30.27461312
134SGK10.27258839
135FGR0.25547312
136CDK190.25362909

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.25063303
2Ribosome_Homo sapiens_hsa030103.14369278
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.11751047
4Measles_Homo sapiens_hsa051622.50748661
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.47212260
6T cell receptor signaling pathway_Homo sapiens_hsa046602.36924578
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.36618112
8Hematopoietic cell lineage_Homo sapiens_hsa046402.32810831
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.16916001
10DNA replication_Homo sapiens_hsa030302.03479156
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.92987051
12Protein export_Homo sapiens_hsa030601.81027865
13Jak-STAT signaling pathway_Homo sapiens_hsa046301.78223486
14Herpes simplex infection_Homo sapiens_hsa051681.76751894
15Asthma_Homo sapiens_hsa053101.69157297
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.68593705
17Leishmaniasis_Homo sapiens_hsa051401.67376203
18Antigen processing and presentation_Homo sapiens_hsa046121.67367454
19Allograft rejection_Homo sapiens_hsa053301.65087810
20Mismatch repair_Homo sapiens_hsa034301.55379427
21Base excision repair_Homo sapiens_hsa034101.55077448
22Non-homologous end-joining_Homo sapiens_hsa034501.44627075
23Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.42360036
24Autoimmune thyroid disease_Homo sapiens_hsa053201.35909609
25Transcriptional misregulation in cancer_Homo sapiens_hsa052021.34819540
26Osteoclast differentiation_Homo sapiens_hsa043801.27403689
27Spliceosome_Homo sapiens_hsa030401.26790796
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.25587760
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.25207398
30Acute myeloid leukemia_Homo sapiens_hsa052211.23101921
31Homologous recombination_Homo sapiens_hsa034401.22632564
32p53 signaling pathway_Homo sapiens_hsa041151.20852816
33B cell receptor signaling pathway_Homo sapiens_hsa046621.18966841
34SNARE interactions in vesicular transport_Homo sapiens_hsa041301.15862285
35Graft-versus-host disease_Homo sapiens_hsa053321.15504496
36RNA polymerase_Homo sapiens_hsa030201.15098742
37Influenza A_Homo sapiens_hsa051641.11326058
38RNA degradation_Homo sapiens_hsa030181.10196876
39Fanconi anemia pathway_Homo sapiens_hsa034601.09820352
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.09146097
41Nucleotide excision repair_Homo sapiens_hsa034201.06752801
42Hepatitis B_Homo sapiens_hsa051611.06175657
43Prostate cancer_Homo sapiens_hsa052151.05591582
44Thyroid cancer_Homo sapiens_hsa052161.05577748
45Platelet activation_Homo sapiens_hsa046111.05333412
46Toll-like receptor signaling pathway_Homo sapiens_hsa046201.04821597
47Basal transcription factors_Homo sapiens_hsa030221.04536069
48Alcoholism_Homo sapiens_hsa050341.03434200
49Toxoplasmosis_Homo sapiens_hsa051451.02501452
50Caffeine metabolism_Homo sapiens_hsa002320.98373826
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98164696
52Staphylococcus aureus infection_Homo sapiens_hsa051500.97091604
53Pyrimidine metabolism_Homo sapiens_hsa002400.91698496
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90781297
55HTLV-I infection_Homo sapiens_hsa051660.88331794
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87782345
57Viral myocarditis_Homo sapiens_hsa054160.87513581
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.86599795
59TNF signaling pathway_Homo sapiens_hsa046680.85993597
60Shigellosis_Homo sapiens_hsa051310.84846502
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84200879
62Legionellosis_Homo sapiens_hsa051340.83662388
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83522703
64Chemokine signaling pathway_Homo sapiens_hsa040620.81949663
65Apoptosis_Homo sapiens_hsa042100.81440443
66Cell cycle_Homo sapiens_hsa041100.81284169
67Other glycan degradation_Homo sapiens_hsa005110.80180652
68Epstein-Barr virus infection_Homo sapiens_hsa051690.79878260
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.79539481
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75698954
71Pertussis_Homo sapiens_hsa051330.71092986
72Viral carcinogenesis_Homo sapiens_hsa052030.70177617
73Hepatitis C_Homo sapiens_hsa051600.69687747
74Chronic myeloid leukemia_Homo sapiens_hsa052200.66483740
75Endometrial cancer_Homo sapiens_hsa052130.64638369
76Sphingolipid metabolism_Homo sapiens_hsa006000.62497571
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.60215210
78Prolactin signaling pathway_Homo sapiens_hsa049170.58828692
79Pancreatic cancer_Homo sapiens_hsa052120.57443932
80Malaria_Homo sapiens_hsa051440.57333096
81N-Glycan biosynthesis_Homo sapiens_hsa005100.56229766
82Renal cell carcinoma_Homo sapiens_hsa052110.54895112
83Small cell lung cancer_Homo sapiens_hsa052220.54474903
84mTOR signaling pathway_Homo sapiens_hsa041500.54235972
85Salmonella infection_Homo sapiens_hsa051320.52342659
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51664023
87Dorso-ventral axis formation_Homo sapiens_hsa043200.51581058
88Glioma_Homo sapiens_hsa052140.51182984
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50512387
90Notch signaling pathway_Homo sapiens_hsa043300.48413632
91HIF-1 signaling pathway_Homo sapiens_hsa040660.47404696
92MAPK signaling pathway_Homo sapiens_hsa040100.46804125
93Type II diabetes mellitus_Homo sapiens_hsa049300.46497470
94Arachidonic acid metabolism_Homo sapiens_hsa005900.45277642
95Pathways in cancer_Homo sapiens_hsa052000.45139884
96ErbB signaling pathway_Homo sapiens_hsa040120.44214676
97Phototransduction_Homo sapiens_hsa047440.43602557
98Non-small cell lung cancer_Homo sapiens_hsa052230.43377447
99MicroRNAs in cancer_Homo sapiens_hsa052060.42649939
100Proteasome_Homo sapiens_hsa030500.42550108
101Purine metabolism_Homo sapiens_hsa002300.42549055
102mRNA surveillance pathway_Homo sapiens_hsa030150.42518163
103Colorectal cancer_Homo sapiens_hsa052100.41827458
104Tuberculosis_Homo sapiens_hsa051520.40649514
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38404544
106Systemic lupus erythematosus_Homo sapiens_hsa053220.38003907
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37422040
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37145976
109Choline metabolism in cancer_Homo sapiens_hsa052310.36455720
110FoxO signaling pathway_Homo sapiens_hsa040680.36195918
111Insulin resistance_Homo sapiens_hsa049310.34866862
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32856746
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31435801
114Type I diabetes mellitus_Homo sapiens_hsa049400.30250312
115GnRH signaling pathway_Homo sapiens_hsa049120.30080845
116Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30023010
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.29864850
118VEGF signaling pathway_Homo sapiens_hsa043700.28962136
119Lysine degradation_Homo sapiens_hsa003100.28910606
120Inositol phosphate metabolism_Homo sapiens_hsa005620.28126154
121Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28104560
122Rheumatoid arthritis_Homo sapiens_hsa053230.27266428
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.24503855
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.21680517
125Circadian rhythm_Homo sapiens_hsa047100.18964302
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.18207542
127Melanoma_Homo sapiens_hsa052180.17258806
128One carbon pool by folate_Homo sapiens_hsa006700.17130426
129African trypanosomiasis_Homo sapiens_hsa051430.15119523

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