IGSF6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to peptidoglycan (GO:0032494)6.70359496
2neutrophil activation involved in immune response (GO:0002283)6.52622162
3neutrophil mediated immunity (GO:0002446)6.41969282
4respiratory burst (GO:0045730)6.14323891
5leukocyte aggregation (GO:0070486)5.71907653
6reactive oxygen species biosynthetic process (GO:1903409)5.69498182
7positive regulation of interleukin-8 biosynthetic process (GO:0045416)5.68057740
8positive regulation by symbiont of host defense response (GO:0052509)5.45205110
9modulation by symbiont of host defense response (GO:0052031)5.45205110
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.45205110
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.45205110
12positive regulation by organism of defense response of other organism involved in symbiotic interact5.45205110
13modulation by symbiont of host immune response (GO:0052553)5.45205110
14positive regulation of gamma-delta T cell activation (GO:0046645)5.37774482
15negative regulation of growth of symbiont in host (GO:0044130)5.22663161
16negative regulation of growth of symbiont involved in interaction with host (GO:0044146)5.22663161
17modulation of growth of symbiont involved in interaction with host (GO:0044144)5.22663161
18regulation of growth of symbiont in host (GO:0044126)5.22663161
19negative regulation of cell killing (GO:0031342)5.15394350
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.15394350
21disruption of cells of other organism involved in symbiotic interaction (GO:0051818)5.03012806
22killing of cells in other organism involved in symbiotic interaction (GO:0051883)5.03012806
23myeloid leukocyte mediated immunity (GO:0002444)4.96068682
24hydrogen peroxide biosynthetic process (GO:0050665)4.94091112
25regulation of chemokine biosynthetic process (GO:0045073)4.91880622
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.80529442
27superoxide anion generation (GO:0042554)4.80107992
28granulocyte activation (GO:0036230)4.55887275
29macrophage activation involved in immune response (GO:0002281)4.48826807
30response to fungus (GO:0009620)4.47393947
31neutrophil activation (GO:0042119)4.47268969
32immunoglobulin mediated immune response (GO:0016064)4.44682826
33detection of bacterium (GO:0016045)4.43726639
34leukocyte mediated cytotoxicity (GO:0001909)4.42182171
35positive regulation of chemokine biosynthetic process (GO:0045080)4.24814630
36cellular response to zinc ion (GO:0071294)4.17297071
37positive regulation of mast cell activation (GO:0033005)4.17036326
38lipopolysaccharide-mediated signaling pathway (GO:0031663)4.16285612
39detection of biotic stimulus (GO:0009595)4.11274357
40antigen processing and presentation of endogenous antigen (GO:0019883)4.06062717
41production of molecular mediator involved in inflammatory response (GO:0002532)3.99344870
42myeloid cell activation involved in immune response (GO:0002275)3.98167844
43positive regulation of mast cell degranulation (GO:0043306)3.95956502
44positive regulation of mast cell activation involved in immune response (GO:0033008)3.95956502
45antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.91643786
46regulation of interleukin-8 biosynthetic process (GO:0045414)3.91358709
47response to host immune response (GO:0052572)3.89825961
48response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.89825961
49regulation of gamma-delta T cell activation (GO:0046643)3.88026582
50regulation of interferon-beta biosynthetic process (GO:0045357)3.83614976
51regulation of mast cell activation (GO:0033003)3.80981877
52defense response to fungus (GO:0050832)3.75826347
53regulation of mast cell degranulation (GO:0043304)3.72502035
54killing of cells of other organism (GO:0031640)3.71862746
55disruption of cells of other organism (GO:0044364)3.71862746
56positive regulation of interferon-alpha production (GO:0032727)3.70983492
57cellular extravasation (GO:0045123)3.68975309
58negative regulation of myeloid cell apoptotic process (GO:0033033)3.61039338
59regulation of interferon-alpha production (GO:0032647)3.52736738
60antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.49349792
61regulation of mast cell activation involved in immune response (GO:0033006)3.48813891
62neutrophil chemotaxis (GO:0030593)3.48268553
63defense response to protozoan (GO:0042832)3.47987345
64T-helper 1 type immune response (GO:0042088)3.46595717
65negative regulation of lymphocyte mediated immunity (GO:0002707)3.46360432
66response to host (GO:0075136)3.46185738
67response to host defenses (GO:0052200)3.46185738
68response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.46185738
69positive regulation of cellular amide metabolic process (GO:0034250)3.45991162
70response to muramyl dipeptide (GO:0032495)3.45186020
71leukocyte migration involved in inflammatory response (GO:0002523)3.44185216
72regulation of myeloid leukocyte mediated immunity (GO:0002886)3.43148205
73sequestering of metal ion (GO:0051238)3.42772925
74negative regulation of interleukin-12 production (GO:0032695)3.41510057
75positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.40609184
76neutrophil migration (GO:1990266)3.38565975
77positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.35545093
78negative regulation of phagocytosis (GO:0050765)3.34024619
79macrophage activation (GO:0042116)3.31880396
80positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.29933372
81phagosome maturation (GO:0090382)3.29843331
82cell killing (GO:0001906)3.29774000
83regulation of leukocyte degranulation (GO:0043300)3.29660432
84detection of molecule of bacterial origin (GO:0032490)3.29337466
85regulation of gamma-delta T cell differentiation (GO:0045586)3.29056917
86B cell mediated immunity (GO:0019724)3.27693720
87negative regulation of mast cell activation (GO:0033004)3.27035480
88regulation of vitamin D biosynthetic process (GO:0060556)3.26966542
89negative regulation of T cell mediated immunity (GO:0002710)3.26653748
90positive regulation of heat generation (GO:0031652)3.26133923
91positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.25334416
92detection of other organism (GO:0098543)3.24291392
93regulation of B cell receptor signaling pathway (GO:0050855)3.23377501
94leukotriene metabolic process (GO:0006691)3.23089653
95microglial cell activation (GO:0001774)3.22599454
96leukocyte degranulation (GO:0043299)3.21946097
97positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.20519093
98regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.17913666
99regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.15550573
100positive regulation of toll-like receptor signaling pathway (GO:0034123)3.15106774
101regulation of tolerance induction (GO:0002643)3.14256528
102regulation of fever generation (GO:0031620)3.13988256
103regulation of hypersensitivity (GO:0002883)3.12972630
104response to protozoan (GO:0001562)3.10439341
105regulation of T cell tolerance induction (GO:0002664)3.10400772
106natural killer cell mediated immunity (GO:0002228)3.08895761
107natural killer cell mediated cytotoxicity (GO:0042267)3.08895761
108positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.07622113
109negative regulation of leukocyte mediated immunity (GO:0002704)3.06095464
110lymphocyte chemotaxis (GO:0048247)3.03783429
111granulocyte chemotaxis (GO:0071621)3.03742633
112cellular response to type I interferon (GO:0071357)3.03305422
113type I interferon signaling pathway (GO:0060337)3.03305422
114regulation of antigen processing and presentation (GO:0002577)3.02839557
115antigen processing and presentation via MHC class Ib (GO:0002475)3.01213626
116response to type I interferon (GO:0034340)3.01033253
117regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.00904086
118positive regulation of leukocyte degranulation (GO:0043302)2.98719372
119detection of external biotic stimulus (GO:0098581)2.96629578
120Arp2/3 complex-mediated actin nucleation (GO:0034314)2.96176610
121positive regulation of antigen processing and presentation (GO:0002579)2.95937774
122myeloid leukocyte activation (GO:0002274)2.95812029
123interferon-gamma-mediated signaling pathway (GO:0060333)2.95728024
124granulocyte migration (GO:0097530)2.94659298
125leukocyte mediated immunity (GO:0002443)2.92525407
126positive regulation of interferon-beta production (GO:0032728)2.92344489
127regulation of dendritic cell antigen processing and presentation (GO:0002604)2.87994249
128regulation of T-helper 2 cell differentiation (GO:0045628)2.85967322
129positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.85624580
130mast cell activation (GO:0045576)2.84467743
131positive regulation of type 2 immune response (GO:0002830)2.83491816
132response to interleukin-15 (GO:0070672)2.82877102
133cellular response to interferon-gamma (GO:0071346)2.82804793
134germinal center formation (GO:0002467)2.82689493
135dendritic cell migration (GO:0036336)2.82422739
136B cell receptor signaling pathway (GO:0050853)2.82196121
137dendritic cell chemotaxis (GO:0002407)2.82159241
138regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.79918501

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.88681894
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.78333117
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.64128640
4IRF8_27001747_Chip-Seq_BMDM_Mouse4.36737884
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.26422692
6MYB_21317192_ChIP-Seq_ERMYB_Mouse4.13894288
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.90693029
8* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.82677367
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.78087926
10E2F7_22180533_ChIP-Seq_HELA_Human3.68067008
11EGR1_19374776_ChIP-ChIP_THP-1_Human3.29206024
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.27485593
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.26639984
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.96984552
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.90523719
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.85145418
17SPI1_23547873_ChIP-Seq_NB4_Human2.75896649
18BRD4_27068464_Chip-Seq_AML-cells_Mouse2.65215122
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.52257195
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.48534729
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.43270228
22RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.36292667
23VDR_24763502_ChIP-Seq_THP-1_Human2.16271651
24SCL_19346495_ChIP-Seq_HPC-7_Human2.07687188
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.07253408
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.07221391
27ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.97387201
28PU_27001747_Chip-Seq_BMDM_Mouse1.96973963
29VDR_21846776_ChIP-Seq_THP-1_Human1.95153096
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.91856034
31PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.83660416
32CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.83189458
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.77110919
34* MYB_26560356_Chip-Seq_TH2_Human1.74681179
35SPI1_23127762_ChIP-Seq_K562_Human1.72622743
36MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.70821399
37CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.69070749
38FOXM1_23109430_ChIP-Seq_U2OS_Human1.68641529
39* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.54071627
40CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.53184313
41LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.51964991
42CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.50895049
43PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.50009776
44VDR_24787735_ChIP-Seq_THP-1_Human1.47465960
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.46387273
46MAF_26560356_Chip-Seq_TH1_Human1.44393623
47MYB_26560356_Chip-Seq_TH1_Human1.42863063
48* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.42327276
49PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40654271
50PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36071881
51* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35372022
52RUNX_20019798_ChIP-Seq_JUKART_Human1.34229850
53SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29036304
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.28120218
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26851964
56LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24452634
57GATA3_26560356_Chip-Seq_TH2_Human1.22126252
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19712791
59SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17930648
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.16510620
61* UTX_26944678_Chip-Seq_JUKART_Human1.12111646
62IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11509066
63NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.09622835
64GATA3_27048872_Chip-Seq_THYMUS_Human1.09092769
65ELF1_17652178_ChIP-ChIP_JURKAT_Human1.08225263
66GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07902726
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06847298
68VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05888503
69E2F4_17652178_ChIP-ChIP_JURKAT_Human1.05268569
70GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04798575
71GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01365648
72E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.00886951
73THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97163285
74SMRT_27268052_Chip-Seq_Bcells_Human0.96496725
75GATA1_19941826_ChIP-Seq_K562_Human0.95660866
76CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.95457117
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.94883342
78GATA1_22025678_ChIP-Seq_K562_Human0.92328205
79KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91402331
80TFEB_21752829_ChIP-Seq_HELA_Human0.91103377
81SPI1_20517297_ChIP-Seq_HL60_Human0.91069901
82BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.89051456
83ERG_20887958_ChIP-Seq_HPC-7_Mouse0.87860949
84STAT1_20625510_ChIP-Seq_HELA_Human0.86985149
85PU.1_20513432_ChIP-Seq_Bcells_Mouse0.86735791
86STAT6_21828071_ChIP-Seq_BEAS2B_Human0.85227452
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83270821
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82168430
89GATA2_21666600_ChIP-Seq_HMVEC_Human0.81473460
90BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81395897
91CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.78129250
92GATA1_19941827_ChIP-Seq_MEL86_Mouse0.76329506
93RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.73790242
94SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.73772350
95MYC_22102868_ChIP-Seq_BL_Human0.72015504
96TCF7_22412390_ChIP-Seq_EML_Mouse0.70973617
97MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.70191580
98GATA1_19941827_ChIP-Seq_MEL_Mouse0.69904559
99TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.69837581
100MAF_26560356_Chip-Seq_TH2_Human0.69150974
101RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.66399489
102KDM2B_26808549_Chip-Seq_DND41_Human0.65941499
103GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.65633374
104NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.64963724
105ELK1_19687146_ChIP-ChIP_HELA_Human0.64425081
106KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.63574387
107BCOR_27268052_Chip-Seq_Bcells_Human0.63555098
108GATA3_26560356_Chip-Seq_TH1_Human0.63086102
109ETS1_22383799_ChIP-Seq_G1ME_Mouse0.62261651
110EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.61683357
111SMAD_19615063_ChIP-ChIP_OVARY_Human0.61534868
112EGR1_19032775_ChIP-ChIP_M12_Human0.60459486
113FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.58889708
114EGR1_23403033_ChIP-Seq_LIVER_Mouse0.58878734
115EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.58733714
116MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.57678693
117GATA2_19941826_ChIP-Seq_K562_Human0.56303097
118RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.53807082
119BCL6_27268052_Chip-Seq_Bcells_Human0.53433434

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.50038667
2MP0009785_altered_susceptibility_to4.39886620
3MP0001835_abnormal_antigen_presentation4.18684198
4MP0002419_abnormal_innate_immunity3.74924266
5MP0002148_abnormal_hypersensitivity_rea3.62710012
6MP0003303_peritoneal_inflammation3.45703132
7MP0005025_abnormal_response_to3.25239928
8MP0005000_abnormal_immune_tolerance3.22755157
9MP0003724_increased_susceptibility_to3.16241348
10MP0006082_CNS_inflammation2.63461071
11MP0005058_abnormal_lysosome_morphology2.62230211
12MP0002452_abnormal_antigen_presenting2.57412884
13MP0003172_abnormal_lysosome_physiology2.48009642
14MP0005464_abnormal_platelet_physiology2.41069610
15MP0002723_abnormal_immune_serum2.40765169
16MP0001533_abnormal_skeleton_physiology2.35581632
17MP0005387_immune_system_phenotype2.34709888
18MP0001790_abnormal_immune_system2.34709888
19MP0001800_abnormal_humoral_immune2.32745628
20MP0001819_abnormal_immune_cell2.29337818
21MP0002420_abnormal_adaptive_immunity2.28471589
22MP0005671_abnormal_response_to2.28082934
23MP0002006_tumorigenesis2.18597786
24MP0000685_abnormal_immune_system2.07090404
25MP0001845_abnormal_inflammatory_respons2.02749251
26MP0000343_altered_response_to2.01882674
27MP0009764_decreased_sensitivity_to2.01538448
28MP0001853_heart_inflammation1.97782613
29MP0003075_altered_response_to1.95887430
30MP0000858_altered_metastatic_potential1.91905776
31MP0003183_abnormal_peptide_metabolism1.89041821
32MP0002405_respiratory_system_inflammati1.88127399
33MP0003448_altered_tumor_morphology1.71010864
34MP0008469_abnormal_protein_level1.69399290
35MP0009333_abnormal_splenocyte_physiolog1.66449329
36MP0000569_abnormal_digit_pigmentation1.66045730
37MP0004947_skin_inflammation1.64974508
38MP0002166_altered_tumor_susceptibility1.64012072
39MP0009278_abnormal_bone_marrow1.63909037
40MP0005167_abnormal_blood-brain_barrier1.62232790
41MP0000716_abnormal_immune_system1.60922411
42MP0010155_abnormal_intestine_physiology1.60735736
43MP0001545_abnormal_hematopoietic_system1.50104362
44MP0005397_hematopoietic_system_phenotyp1.50104362
45MP0002398_abnormal_bone_marrow1.49582939
46MP0003191_abnormal_cellular_cholesterol1.47982750
47MP0003186_abnormal_redox_activity1.43995684
48MP0005174_abnormal_tail_pigmentation1.40886260
49MP0004510_myositis1.40121818
50MP0000604_amyloidosis1.34025744
51MP0005166_decreased_susceptibility_to1.33213365
52MP0002998_abnormal_bone_remodeling1.33057947
53MP0002429_abnormal_blood_cell1.32072299
54MP0004782_abnormal_surfactant_physiolog1.30406002
55MP0005164_abnormal_response_to1.27749709
56MP0000689_abnormal_spleen_morphology1.26333202
57MP0002396_abnormal_hematopoietic_system1.22875401
58MP0005451_abnormal_body_composition1.21932851
59MP0003806_abnormal_nucleotide_metabolis1.21001303
60MP0002722_abnormal_immune_system1.20485549
61MP0003656_abnormal_erythrocyte_physiolo1.18938703
62MP0003690_abnormal_glial_cell1.14784913
63MP0002132_abnormal_respiratory_system1.13136527
64MP0005310_abnormal_salivary_gland1.11132462
65MP0003300_gastrointestinal_ulcer1.10581898
66MP0009763_increased_sensitivity_to1.07886460
67MP0010307_abnormal_tumor_latency1.07752124
68MP0000490_abnormal_crypts_of1.07042206
69MP0003828_pulmonary_edema1.05121262
70MP0001851_eye_inflammation1.04562864
71MP0005390_skeleton_phenotype1.01496373
72MP0004381_abnormal_hair_follicle0.95349929
73MP0000465_gastrointestinal_hemorrhage0.93957902
74MP0008004_abnormal_stomach_pH0.93928073
75MP0002277_abnormal_respiratory_mucosa0.90408416
76MP0000015_abnormal_ear_pigmentation0.89432251
77MP0000249_abnormal_blood_vessel0.84702794
78MP0005076_abnormal_cell_differentiation0.82317507
79MP0004808_abnormal_hematopoietic_stem0.82092100
80MP0002933_joint_inflammation0.81281436
81MP0009840_abnormal_foam_cell0.80860871
82MP0008260_abnormal_autophagy0.77255281
83MP0003195_calcinosis0.76918991
84MP0005075_abnormal_melanosome_morpholog0.76659346
85MP0006054_spinal_hemorrhage0.73609835
86MP0004883_abnormal_blood_vessel0.73409061
87MP0000371_diluted_coat_color0.73190958
88MP0008057_abnormal_DNA_replication0.72137015
89MP0003763_abnormal_thymus_physiology0.71756113
90MP0008873_increased_physiological_sensi0.71191912
91MP0003566_abnormal_cell_adhesion0.69931819
92MP0009765_abnormal_xenobiotic_induced0.69090318
93MP0003329_amyloid_beta_deposits0.68380768
94MP0002332_abnormal_exercise_endurance0.66935066
95MP0003866_abnormal_defecation0.66258870
96MP0003795_abnormal_bone_structure0.65618920
97MP0001663_abnormal_digestive_system0.65398401
98MP0002019_abnormal_tumor_incidence0.64673372
99MP0003693_abnormal_embryo_hatching0.60964344
100MP0000920_abnormal_myelination0.60081001
101MP0003045_fibrosis0.59388061
102MP0000703_abnormal_thymus_morphology0.58896550
103MP0002139_abnormal_hepatobiliary_system0.58884905
104MP0008874_decreased_physiological_sensi0.58845935
105MP0002138_abnormal_hepatobiliary_system0.55533889
106MP0002254_reproductive_system_inflammat0.55051191
107MP0004130_abnormal_muscle_cell0.54596121
108MP0005584_abnormal_enzyme/coenzyme_acti0.52811368
109MP0001986_abnormal_taste_sensitivity0.52801396
110MP0005319_abnormal_enzyme/_coenzyme0.52699925
111MP0003646_muscle_fatigue0.52253144
112MP0005165_increased_susceptibility_to0.49602275
113MP0002693_abnormal_pancreas_physiology0.49364201
114MP0010352_gastrointestinal_tract_polyps0.48809134
115MP0000609_abnormal_liver_physiology0.48662695
116MP0005023_abnormal_wound_healing0.48123798
117MP0002136_abnormal_kidney_physiology0.47733923
118MP0001873_stomach_inflammation0.46518657

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)8.48396429
2Eczematoid dermatitis (HP:0000976)7.83826796
3Recurrent bacterial skin infections (HP:0005406)7.74050361
4Recurrent gram-negative bacterial infections (HP:0005420)6.92464094
5Mediastinal lymphadenopathy (HP:0100721)5.53058059
6Obstructive lung disease (HP:0006536)5.28286971
7Chronic obstructive pulmonary disease (HP:0006510)5.28286971
8Abnormality of macrophages (HP:0004311)5.21865313
9Gingivitis (HP:0000230)4.79611050
10Recurrent skin infections (HP:0001581)4.54496165
11Elevated erythrocyte sedimentation rate (HP:0003565)4.44414892
12Stomatitis (HP:0010280)4.34188007
13Autoimmune thrombocytopenia (HP:0001973)4.16893392
14Myositis (HP:0100614)4.13257808
15Periodontitis (HP:0000704)4.05635899
16Vacuolated lymphocytes (HP:0001922)3.97990850
17Recurrent fungal infections (HP:0002841)3.75335350
18Systemic lupus erythematosus (HP:0002725)3.70507574
19Orchitis (HP:0100796)3.69354253
20Increased neuronal autofluorescent lipopigment (HP:0002074)3.55337747
21Increased cerebral lipofuscin (HP:0011813)3.53787141
22Optic neuritis (HP:0100653)3.35155182
23Retrobulbar optic neuritis (HP:0100654)3.35155182
24Cellulitis (HP:0100658)3.33080325
25T lymphocytopenia (HP:0005403)3.28999502
26Urticaria (HP:0001025)3.27574187
27Meningitis (HP:0001287)3.25776161
28Encephalitis (HP:0002383)3.22557020
29Vasculitis (HP:0002633)3.21545764
30Abnormality of T cell number (HP:0011839)3.19345542
31Abnormality of the prostate (HP:0008775)3.14974429
32Thrombocytosis (HP:0001894)3.14600907
33Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.13270689
34Recurrent viral infections (HP:0004429)3.11032631
35Abnormal delayed hypersensitivity skin test (HP:0002963)3.05933247
36Eosinophilia (HP:0001880)2.97277088
37Agnosia (HP:0010524)2.96971056
38Axonal loss (HP:0003447)2.96129150
39Pulmonary infiltrates (HP:0002113)2.94883226
40Recurrent pneumonia (HP:0006532)2.94067084
41Prostate neoplasm (HP:0100787)2.93138828
42Basal ganglia calcification (HP:0002135)2.92885835
43Pustule (HP:0200039)2.91690323
44Leukocytosis (HP:0001974)2.91589983
45Loss of speech (HP:0002371)2.88916972
46Joint hemorrhage (HP:0005261)2.81245599
47Disinhibition (HP:0000734)2.79643293
48Spontaneous hematomas (HP:0007420)2.79279137
49Osteomyelitis (HP:0002754)2.74589867
50Petechiae (HP:0000967)2.72727547
51Abnormality of liposaccharide metabolism (HP:0010968)2.67589294
52Abnormality of glycosphingolipid metabolism (HP:0004343)2.67589294
53Abnormality of glycolipid metabolism (HP:0010969)2.67589294
54Glomerulonephritis (HP:0000099)2.65067831
55Granulocytopenia (HP:0001913)2.63025505
56Anorexia (HP:0002039)2.62729839
57Pulmonary embolism (HP:0002204)2.62147189
58Recurrent cutaneous fungal infections (HP:0011370)2.60264564
59Chronic mucocutaneous candidiasis (HP:0002728)2.60264564
60Interstitial pulmonary disease (HP:0006530)2.57588362
61Thick nail (HP:0001805)2.56658865
62Hypergammaglobulinemia (HP:0010702)2.49277060
63Hemoptysis (HP:0002105)2.46831145
64Episodic fever (HP:0001954)2.43890750
65Keratoconjunctivitis sicca (HP:0001097)2.43336310
66Recurrent lower respiratory tract infections (HP:0002783)2.43156198
67Hepatosplenomegaly (HP:0001433)2.42858527
68Sepsis (HP:0100806)2.42661065
69Dysostosis multiplex (HP:0000943)2.41275348
70Purpura (HP:0000979)2.34634170
71Prolonged bleeding time (HP:0003010)2.33089567
72Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.32408044
73Abnormality of eosinophils (HP:0001879)2.29844152
74Abnormality of the pleura (HP:0002103)2.29576534
75Increased IgM level (HP:0003496)2.28785440
76Gingival bleeding (HP:0000225)2.27572089
77Peritonitis (HP:0002586)2.26931534
78Increased IgE level (HP:0003212)2.26444168
79Polyneuropathy (HP:0001271)2.25979736
80Skin ulcer (HP:0200042)2.24655128
81Hypochromic microcytic anemia (HP:0004840)2.21210704
82Chest pain (HP:0100749)2.21065494
83Keratoconjunctivitis (HP:0001096)2.20102398
84Epistaxis (HP:0000421)2.20005065
85Mutism (HP:0002300)2.18379887
86Papilledema (HP:0001085)2.17076459
87Vertigo (HP:0002321)2.16084725
88Poor head control (HP:0002421)2.14625281
89Urinary glycosaminoglycan excretion (HP:0003541)2.11019516
90Mucopolysacchariduria (HP:0008155)2.11019516
91Increased serum ferritin (HP:0003281)2.10362294
92Gangrene (HP:0100758)2.08887357
93Nausea (HP:0002018)2.07624429
94Abnormality of T cell physiology (HP:0011840)2.07513131
95Hypochromic anemia (HP:0001931)2.06736193
96Abnormality of the endocardium (HP:0004306)2.03935175
97Myocardial infarction (HP:0001658)2.03679454
98Glomerulopathy (HP:0100820)2.02543475
99Arterial thrombosis (HP:0004420)2.02006457
100Abnormality of iron homeostasis (HP:0011031)2.01486477
101Cheilitis (HP:0100825)2.01173547
102Inflammation of the large intestine (HP:0002037)1.99938957
103Gastrointestinal infarctions (HP:0005244)1.99268095
104Reduced antithrombin III activity (HP:0001976)1.97816828
105Abnormality of mucopolysaccharide metabolism (HP:0011020)1.96242900
106Abnormality of polysaccharide metabolism (HP:0011012)1.96242900
107Abnormality of glycosaminoglycan metabolism (HP:0004371)1.96242900
108Tetraparesis (HP:0002273)1.94948785
109Abnormality of the peritoneum (HP:0002585)1.93459285
110Chronic otitis media (HP:0000389)1.93278433
111Keratitis (HP:0000491)1.90477762
112Abnormality of the pericardium (HP:0001697)1.89913516
113Inappropriate behavior (HP:0000719)1.87123523
114Restrictive lung disease (HP:0002091)1.87036569
115Premature loss of primary teeth (HP:0006323)1.86042184
116Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.84945115
117IgM deficiency (HP:0002850)1.82441813
118Pathologic fracture (HP:0002756)1.82167892
119Nephritis (HP:0000123)1.81388473
120Abnormality of T cells (HP:0002843)1.80913785
121Chromosomal breakage induced by crosslinking agents (HP:0003221)1.78448699
122Hematochezia (HP:0002573)1.77477773
123Amyloidosis (HP:0011034)1.77393204
124Chromsome breakage (HP:0040012)1.75742966
125Neoplasm of head and neck (HP:0012288)1.74861463
126Esophageal neoplasm (HP:0100751)1.74861463
127Bone pain (HP:0002653)1.73409230
128Neutropenia (HP:0001875)1.73085889

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.86508620
2IRAK44.72512672
3BLK4.52427786
4MAP3K144.14916249
5IRAK33.22534287
6TXK2.84906899
7TBK12.61128479
8MAP4K12.50799370
9TYK22.18932374
10ERN12.13375681
11IKBKE2.12452373
12KIT1.88821945
13TEC1.88621786
14ZAP701.84852607
15PBK1.83994697
16JAK31.71447216
17BTK1.70760188
18CSK1.68703573
19IKBKB1.62668019
20PIM21.61372390
21SYK1.60001652
22TAOK31.57518899
23TNK21.56970403
24CLK11.55889615
25JAK11.44034883
26TESK11.42879243
27HCK1.38703031
28FES1.38150065
29TAOK11.37164456
30ACVR1B1.35928973
31MAP2K31.35769322
32LYN1.35683137
33MAP3K121.31945554
34EPHB11.27195549
35FGR1.25995078
36EIF2AK21.18659694
37CDK191.16771610
38CSF1R1.15151962
39ABL21.14028430
40TRPM71.08076531
41ERBB31.07812123
42NEK91.05142001
43RPS6KA41.02792588
44PIM11.02529767
45LCK1.00994472
46YES11.00405381
47EIF2AK30.98828987
48CHUK0.98339616
49STK100.97109348
50JAK20.95883696
51MATK0.95000993
52PRKCD0.94261501
53TESK20.92775868
54STK40.83894211
55MAP3K20.83867247
56PDK10.83464651
57FRK0.82449134
58ITK0.82398600
59DAPK20.80001245
60KSR20.76405565
61BRSK20.74759246
62BMPR20.72739606
63MAP3K130.71849782
64MARK30.70136529
65PDPK10.69979039
66CAMKK20.68838881
67TAOK20.68493096
68MAP2K60.66581268
69ABL10.65313363
70RPS6KA60.63797157
71CDC42BPA0.62140896
72PAK40.61060942
73PTK2B0.57571654
74TGFBR20.57027710
75PIK3CG0.56886112
76GRK70.56806102
77RPS6KC10.55671372
78RPS6KL10.55671372
79MAP2K40.55438304
80NME20.55320600
81BMX0.53215147
82CDK40.52511829
83EGFR0.51704879
84EPHA30.50913765
85RIPK10.49511814
86EIF2AK10.49185635
87MST1R0.49040367
88OXSR10.48449380
89STK110.48298042
90MAP3K50.46715995
91MARK20.45715477
92MAPK120.45590937
93CDK60.45134900
94MOS0.44353232
95GRK60.43746721
96CAMKK10.43123525
97MAPK40.42416165
98SIK30.42174522
99IRAK20.41975649
100RPS6KA20.41607257
101SGK30.41262769
102SGK20.40552638
103PRPF4B0.40505185
104ADRBK20.39692926
105IRAK10.38955601
106MAPK70.38835773
107MAP3K110.38816440
108FYN0.37431846
109FGFR30.36917916
110MAPKAPK20.36243248
111MAP3K30.35571843
112PRKCQ0.35416104
113ATR0.33177129
114TTN0.33169788
115MAP3K60.33079920
116PRKD20.32718274
117HIPK20.32698684
118DYRK1B0.31195766
119PTK60.31183566
120KSR10.29601778
121MST40.29182216
122PRKG20.28279323
123WNK10.28204094
124LRRK20.27505057
125DAPK10.25989364
126LIMK10.25165866
127ZAK0.23811297
128MAP3K80.23548800
129ARAF0.22527637
130FLT30.22262453
131SIK20.22072229
132MAP3K10.21211254

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051404.00475212
2Staphylococcus aureus infection_Homo sapiens_hsa051503.44068470
3Graft-versus-host disease_Homo sapiens_hsa053323.04608625
4Legionellosis_Homo sapiens_hsa051342.91335832
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.69639391
6NOD-like receptor signaling pathway_Homo sapiens_hsa046212.60716203
7Pertussis_Homo sapiens_hsa051332.59267707
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.49294181
9Osteoclast differentiation_Homo sapiens_hsa043802.48824101
10Tuberculosis_Homo sapiens_hsa051522.41719382
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.41099521
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.27955714
13Malaria_Homo sapiens_hsa051442.24925777
14Phagosome_Homo sapiens_hsa041452.17215894
15Asthma_Homo sapiens_hsa053102.14360114
16Rheumatoid arthritis_Homo sapiens_hsa053232.09121703
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.03429764
18Lysosome_Homo sapiens_hsa041421.99691978
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.96543949
20Salmonella infection_Homo sapiens_hsa051321.93936549
21Measles_Homo sapiens_hsa051621.89794439
22Allograft rejection_Homo sapiens_hsa053301.80700826
23Other glycan degradation_Homo sapiens_hsa005111.71743141
24African trypanosomiasis_Homo sapiens_hsa051431.70969466
25Type I diabetes mellitus_Homo sapiens_hsa049401.70234012
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.67576392
27Influenza A_Homo sapiens_hsa051641.63429136
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.60219507
29TNF signaling pathway_Homo sapiens_hsa046681.60072380
30Hematopoietic cell lineage_Homo sapiens_hsa046401.57796723
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.54922165
32Herpes simplex infection_Homo sapiens_hsa051681.53769624
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.51019622
34B cell receptor signaling pathway_Homo sapiens_hsa046621.34189061
35Toxoplasmosis_Homo sapiens_hsa051451.33457506
36Antigen processing and presentation_Homo sapiens_hsa046121.27408921
37Chemokine signaling pathway_Homo sapiens_hsa040621.26632300
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.23591600
39Apoptosis_Homo sapiens_hsa042101.22439433
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.22277491
41Shigellosis_Homo sapiens_hsa051311.15758976
42Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.05512240
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.04646924
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01984400
45Hepatitis B_Homo sapiens_hsa051610.93709781
46Jak-STAT signaling pathway_Homo sapiens_hsa046300.92703932
47Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88555672
48Amoebiasis_Homo sapiens_hsa051460.88485711
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86742871
50Hepatitis C_Homo sapiens_hsa051600.84697217
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83359967
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73193469
53Complement and coagulation cascades_Homo sapiens_hsa046100.73146333
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71260306
55Viral myocarditis_Homo sapiens_hsa054160.70951066
56Primary immunodeficiency_Homo sapiens_hsa053400.70907325
57DNA replication_Homo sapiens_hsa030300.69922603
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69785589
59Pentose phosphate pathway_Homo sapiens_hsa000300.67618839
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66525298
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62819695
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62093402
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.60571775
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58023662
65Autoimmune thyroid disease_Homo sapiens_hsa053200.57780648
66Renin-angiotensin system_Homo sapiens_hsa046140.57394524
67Platelet activation_Homo sapiens_hsa046110.55776328
68Epstein-Barr virus infection_Homo sapiens_hsa051690.54034963
69Prion diseases_Homo sapiens_hsa050200.53746095
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50288641
71Pancreatic cancer_Homo sapiens_hsa052120.50225598
72T cell receptor signaling pathway_Homo sapiens_hsa046600.49852337
73Prolactin signaling pathway_Homo sapiens_hsa049170.49319270
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46957399
75Base excision repair_Homo sapiens_hsa034100.46344309
76Endocytosis_Homo sapiens_hsa041440.43397360
77Dorso-ventral axis formation_Homo sapiens_hsa043200.42740447
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42685023
79Regulation of autophagy_Homo sapiens_hsa041400.42262475
80Sphingolipid metabolism_Homo sapiens_hsa006000.41623421
81Acute myeloid leukemia_Homo sapiens_hsa052210.41234738
82Non-small cell lung cancer_Homo sapiens_hsa052230.40607961
83Homologous recombination_Homo sapiens_hsa034400.39545510
84HIF-1 signaling pathway_Homo sapiens_hsa040660.38713476
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.38363392
86Chronic myeloid leukemia_Homo sapiens_hsa052200.37923359
87Collecting duct acid secretion_Homo sapiens_hsa049660.37654580
88Galactose metabolism_Homo sapiens_hsa000520.37347299
89Proteasome_Homo sapiens_hsa030500.35230148
90Systemic lupus erythematosus_Homo sapiens_hsa053220.33584613
91Ether lipid metabolism_Homo sapiens_hsa005650.31680076
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31154623
93Arachidonic acid metabolism_Homo sapiens_hsa005900.29539833
94Renal cell carcinoma_Homo sapiens_hsa052110.29432791
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.28269447
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27912329
97FoxO signaling pathway_Homo sapiens_hsa040680.26734619
98Protein export_Homo sapiens_hsa030600.26512207
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.26375675
100GnRH signaling pathway_Homo sapiens_hsa049120.25073163
101Viral carcinogenesis_Homo sapiens_hsa052030.24878616
102Mineral absorption_Homo sapiens_hsa049780.24675954
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.24330167
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.24247311
105Histidine metabolism_Homo sapiens_hsa003400.23938960
106HTLV-I infection_Homo sapiens_hsa051660.21995596
107Type II diabetes mellitus_Homo sapiens_hsa049300.21715434
108Starch and sucrose metabolism_Homo sapiens_hsa005000.20502084
109p53 signaling pathway_Homo sapiens_hsa041150.20168704
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19554733
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.19516074
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.19149255
113MAPK signaling pathway_Homo sapiens_hsa040100.19036015
114Notch signaling pathway_Homo sapiens_hsa043300.18456020
115Insulin resistance_Homo sapiens_hsa049310.18188507
116N-Glycan biosynthesis_Homo sapiens_hsa005100.17679090
117Small cell lung cancer_Homo sapiens_hsa052220.17274422
118ABC transporters_Homo sapiens_hsa020100.16089985
119VEGF signaling pathway_Homo sapiens_hsa043700.15710218
120Steroid biosynthesis_Homo sapiens_hsa001000.14720435

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »