IGSF10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium movement (GO:0003341)9.88955997
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.69466389
3motile cilium assembly (GO:0044458)8.69547384
4regulation of female gonad development (GO:2000194)8.52756435
5epithelial cilium movement (GO:0003351)8.06251851
6regulation of acrosome reaction (GO:0060046)7.88935628
7bone trabecula formation (GO:0060346)7.34196727
8multicellular organism reproduction (GO:0032504)6.41779065
9sequestering of extracellular ligand from receptor (GO:0035581)6.38037120
10axoneme assembly (GO:0035082)6.18906140
11protein kinase C signaling (GO:0070528)6.18618163
12mesenchymal-epithelial cell signaling (GO:0060638)5.97717210
13collagen fibril organization (GO:0030199)5.78960391
14protein heterotrimerization (GO:0070208)5.72589670
15left/right pattern formation (GO:0060972)5.63211505
16oocyte development (GO:0048599)5.56130927
17craniofacial suture morphogenesis (GO:0097094)5.50746489
18chondrocyte proliferation (GO:0035988)5.30914182
19planar cell polarity pathway involved in neural tube closure (GO:0090179)5.14215726
20regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.96232250
21lateral sprouting from an epithelium (GO:0060601)4.88508904
22regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.84681125
23neuron projection extension involved in neuron projection guidance (GO:1902284)4.78941415
24axon extension involved in axon guidance (GO:0048846)4.78941415
25dermatan sulfate biosynthetic process (GO:0030208)4.73867880
26regulation of hypersensitivity (GO:0002883)4.65278757
27left/right axis specification (GO:0070986)4.61318675
28chondrocyte development (GO:0002063)4.55415153
29reproduction (GO:0000003)4.53693814
30embryonic cranial skeleton morphogenesis (GO:0048701)4.49753819
31cell proliferation involved in metanephros development (GO:0072203)4.45685869
32regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.44293967
33regulation of cilium movement (GO:0003352)4.41242335
34regulation of non-canonical Wnt signaling pathway (GO:2000050)4.36211732
35regulation of branching involved in salivary gland morphogenesis (GO:0060693)4.31884287
36dermatan sulfate metabolic process (GO:0030205)4.31380332
37primary alcohol catabolic process (GO:0034310)4.24646449
38ventricular system development (GO:0021591)4.24463663
39prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.21783531
40positive regulation of humoral immune response (GO:0002922)4.21117509
41cranial suture morphogenesis (GO:0060363)4.19009198
42metanephric mesenchyme development (GO:0072075)4.14958889
43extracellular regulation of signal transduction (GO:1900115)4.13931119
44extracellular negative regulation of signal transduction (GO:1900116)4.13931119
45negative regulation of reproductive process (GO:2000242)4.10127922
46definitive hemopoiesis (GO:0060216)4.08443876
47negative regulation of chondrocyte differentiation (GO:0032331)4.02899439
48outer ear morphogenesis (GO:0042473)4.02122048
49cell proliferation involved in kidney development (GO:0072111)3.99397246
50interkinetic nuclear migration (GO:0022027)3.89899418
51middle ear morphogenesis (GO:0042474)3.87816218
52vitamin transmembrane transport (GO:0035461)3.87717289
53collagen catabolic process (GO:0030574)3.87232699
54collagen metabolic process (GO:0032963)3.86196037
55head development (GO:0060322)3.82190314
56convergent extension (GO:0060026)3.81538721
57endodermal cell differentiation (GO:0035987)3.81252168
58G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.80519451
59kidney mesenchyme development (GO:0072074)3.79885239
60retinal cone cell development (GO:0046549)3.78224840
61regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.70793787
62positive regulation of reproductive process (GO:2000243)3.67915801
63negative regulation of catenin import into nucleus (GO:0035414)3.66830187
64microtubule bundle formation (GO:0001578)3.62868072
65multicellular organismal macromolecule metabolic process (GO:0044259)3.62247876
66Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.61265760
67ethanol metabolic process (GO:0006067)3.60748821
68mesenchymal cell proliferation (GO:0010463)3.60406197
69glomerular filtration (GO:0003094)3.60359918
70regulation of response to osmotic stress (GO:0047484)3.60223049
71positive regulation of mesenchymal cell proliferation (GO:0002053)3.60066669
72intraciliary transport (GO:0042073)3.59983191
73radial glial cell differentiation (GO:0060019)3.59824527
74regulation of establishment of planar polarity (GO:0090175)3.56969295
75DNA methylation involved in gamete generation (GO:0043046)3.56909561
76multicellular organismal catabolic process (GO:0044243)3.53474212
77insulin-like growth factor receptor signaling pathway (GO:0048009)3.49983045
78hippo signaling (GO:0035329)3.46480887
79glial cell migration (GO:0008347)3.45297164
80regulation of mesenchymal cell proliferation (GO:0010464)3.45233065
81cell migration involved in heart development (GO:0060973)3.43887971
82single fertilization (GO:0007338)3.43208249
83centriole assembly (GO:0098534)3.43116354
84extracellular fibril organization (GO:0043206)3.42113417
85multicellular organismal metabolic process (GO:0044236)3.40660495
86branching involved in prostate gland morphogenesis (GO:0060442)3.40126093
87binding of sperm to zona pellucida (GO:0007339)3.39769115
88negative regulation of humoral immune response (GO:0002921)3.38877792
89regulation of phospholipid biosynthetic process (GO:0071071)3.37617531
90negative regulation of embryonic development (GO:0045992)3.36804692
91extracellular matrix assembly (GO:0085029)3.36526423
92cilium organization (GO:0044782)3.35585503
93phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.34756107
94negative regulation of cartilage development (GO:0061037)3.33343963
95lateral ventricle development (GO:0021670)3.33271724
96regulation of histone H3-K9 methylation (GO:0051570)3.32836172
97regulation of microtubule-based movement (GO:0060632)3.32730015
98bone morphogenesis (GO:0060349)3.27008719
99negative chemotaxis (GO:0050919)3.26943672
100fertilization (GO:0009566)3.26611556
101response to xenobiotic stimulus (GO:0009410)3.26100661
102skin morphogenesis (GO:0043589)3.23918244
103regulation of steroid hormone secretion (GO:2000831)3.21688689
104extracellular matrix disassembly (GO:0022617)3.20126889
105blood vessel maturation (GO:0001955)3.18032841
106cilium assembly (GO:0042384)3.16625939
107meiotic cell cycle (GO:0051321)3.15935765
108female gamete generation (GO:0007292)3.13561589
109renal filtration (GO:0097205)3.12689735
110regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.12307953
111body morphogenesis (GO:0010171)3.12127592
112regulation of catenin import into nucleus (GO:0035412)3.11549545
113citrulline biosynthetic process (GO:0019240)3.11011469
114cellular response to vitamin D (GO:0071305)3.10620024
115cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.09769649
116face morphogenesis (GO:0060325)3.08715862
117non-canonical Wnt signaling pathway (GO:0035567)3.06801874
118positive regulation of catenin import into nucleus (GO:0035413)3.05795957
119paraxial mesoderm development (GO:0048339)3.04552918
120regulation of interleukin-5 production (GO:0032674)3.04416989
121one-carbon compound transport (GO:0019755)3.04024189
122axis elongation (GO:0003401)3.03677895
123diterpenoid biosynthetic process (GO:0016102)3.03621728
124camera-type eye morphogenesis (GO:0048593)3.03158248
125trabecula formation (GO:0060343)3.02562785
126regulation of chondrocyte differentiation (GO:0032330)3.02239790
127positive regulation of smoothened signaling pathway (GO:0045880)2.99829422
128embryonic skeletal joint morphogenesis (GO:0060272)2.98567690
129regulation of germinal center formation (GO:0002634)2.97347296
130fibril organization (GO:0097435)2.96676646
131smooth muscle tissue development (GO:0048745)2.96632878
132polarized epithelial cell differentiation (GO:0030859)2.96463328
133regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.96335208
134regulation of cartilage development (GO:0061035)2.95574040
135embryonic body morphogenesis (GO:0010172)2.95517723
136regulation of DNA methylation (GO:0044030)2.94334798
137anatomical structure regression (GO:0060033)2.93246252
138negative regulation of axon extension involved in axon guidance (GO:0048843)2.93023904
139regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.92988169
140hindlimb morphogenesis (GO:0035137)2.92468257
141organ induction (GO:0001759)2.91701081
142peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.91619915
143piRNA metabolic process (GO:0034587)2.89398084
144chondroitin sulfate catabolic process (GO:0030207)2.87663991
145embryonic hindlimb morphogenesis (GO:0035116)2.87638727
146microtubule-based movement (GO:0007018)2.85967897
147prostate gland epithelium morphogenesis (GO:0060740)2.85048453
148cartilage morphogenesis (GO:0060536)2.83806518
149negative regulation of fatty acid transport (GO:2000192)2.82127825
150heart morphogenesis (GO:0003007)2.81061309
151artery development (GO:0060840)2.79493705
152branching involved in salivary gland morphogenesis (GO:0060445)2.79280307
153regulation of axon extension involved in axon guidance (GO:0048841)2.78908092
154surfactant homeostasis (GO:0043129)2.78055233
155ethanol oxidation (GO:0006069)2.78024778
156histone H3-K9 demethylation (GO:0033169)2.77827793
157mesenchyme development (GO:0060485)2.77732426
158positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.77249480
159histone lysine demethylation (GO:0070076)2.76839115
160establishment of apical/basal cell polarity (GO:0035089)2.75019799
161positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.74501857
162regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.74404937
163lung epithelium development (GO:0060428)2.71096859
164cytoplasmic microtubule organization (GO:0031122)2.70743830
165keratan sulfate catabolic process (GO:0042340)2.69614288
166cellular component assembly involved in morphogenesis (GO:0010927)2.68948932
167sperm-egg recognition (GO:0035036)2.60839688
168centriole replication (GO:0007099)2.60616167
169pyrimidine-containing compound transmembrane transport (GO:0072531)2.58526661
170negative regulation of histone methylation (GO:0031061)2.58385602
171histone demethylation (GO:0016577)2.56455458
172regulation of reproductive process (GO:2000241)2.55894215
173histone H3-K4 trimethylation (GO:0080182)2.51790334
174phosphatidylinositol dephosphorylation (GO:0046856)2.51145759
175positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.48471943
176regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.44177256
177regulation of humoral immune response (GO:0002920)2.43927073
178regulation of secondary heart field cardioblast proliferation (GO:0003266)2.43549874
179regulation of cardioblast proliferation (GO:0003264)2.43549874
180embryo implantation (GO:0007566)2.42996091
181retinal rod cell development (GO:0046548)2.42686215
182histone H3-K36 demethylation (GO:0070544)2.42133329
183regulation of steroid hormone biosynthetic process (GO:0090030)2.41432002
184cell projection assembly (GO:0030031)2.40808504
185cellular response to exogenous dsRNA (GO:0071360)2.40560740
186sperm capacitation (GO:0048240)2.39475242
187cell-cell recognition (GO:0009988)2.38509260
188pericardium development (GO:0060039)2.37705082
189phospholipid dephosphorylation (GO:0046839)2.37349726
190positive regulation of steroid hormone secretion (GO:2000833)2.32894287
191regulation of interleukin-4 production (GO:0032673)2.31638804
192cilium or flagellum-dependent cell motility (GO:0001539)12.7347186
193axonemal dynein complex assembly (GO:0070286)12.2744966

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.36050012
2PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse4.34183412
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.04987541
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.64984045
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.53174836
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.42075399
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.35604261
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.84795409
9WT1_19549856_ChIP-ChIP_CCG9911_Human2.81463867
10* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.71512540
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.69575116
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.66074028
13* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.53816027
14FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.48936817
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.35196217
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.35196217
17EZH2_22144423_ChIP-Seq_EOC_Human2.32453634
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.26205811
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.16461880
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.15624430
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.13812891
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.12178460
23PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.09132703
24RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.03495148
25EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.00592792
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.99725975
27GBX2_23144817_ChIP-Seq_PC3_Human1.98255363
28WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.95134929
29JARID2_20064375_ChIP-Seq_MESCs_Mouse1.94926436
30AR_21572438_ChIP-Seq_LNCaP_Human1.90134892
31ESR1_20079471_ChIP-ChIP_T-47D_Human1.88423808
32JARID2_20075857_ChIP-Seq_MESCs_Mouse1.88333909
33EP300_21415370_ChIP-Seq_HL-1_Mouse1.86820934
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.85870965
35SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.83381305
36TP53_18474530_ChIP-ChIP_U2OS_Human1.82232595
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.80350795
38* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.80268399
39HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.79308149
40CJUN_26792858_Chip-Seq_BT549_Human1.79026259
41NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.76723508
42NRF2_20460467_ChIP-Seq_MEFs_Mouse1.76723508
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.74945005
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74142394
45BRD4_25478319_ChIP-Seq_HGPS_Human1.71493761
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.69872249
47RNF2_27304074_Chip-Seq_ESCs_Mouse1.68807808
48RARG_19884340_ChIP-ChIP_MEFs_Mouse1.66117305
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.65883564
50ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.63823911
51TP53_20018659_ChIP-ChIP_R1E_Mouse1.62816494
52ISL1_27105846_Chip-Seq_CPCs_Mouse1.62350598
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.60818605
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.59827685
55VDR_24787735_ChIP-Seq_THP-1_Human1.54935845
56CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.53161568
57TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.52851122
58MTF2_20144788_ChIP-Seq_MESCs_Mouse1.50501596
59TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47633366
60FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.46747385
61PPAR_26484153_Chip-Seq_NCI-H1993_Human1.46456485
62ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.46104213
63ESR2_21235772_ChIP-Seq_MCF-7_Human1.44348492
64TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.44008307
65TP63_17297297_ChIP-ChIP_HaCaT_Human1.43888370
66RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.43664207
67AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.40137116
68SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38706988
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.38049349
70TP53_16413492_ChIP-PET_HCT116_Human1.37054778
71SCL_19346495_ChIP-Seq_HPC-7_Human1.35880608
72TBX20_22328084_ChIP-Seq_HEART_Mouse1.34310878
73TBX20_22080862_ChIP-Seq_HEART_Mouse1.34310878
74* TP63_23658742_ChIP-Seq_EP156T_Human1.34121080
75CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31695518
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31664030
77ESR1_21235772_ChIP-Seq_MCF-7_Human1.31337050
78TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.29737088
79* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.29550446
80TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29052886
81FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.28634828
82STAT3_23295773_ChIP-Seq_U87_Human1.28556230
83DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.27618814
84NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.26552714
85VDR_24763502_ChIP-Seq_THP-1_Human1.26192348
86SMRT_27268052_Chip-Seq_Bcells_Human1.23971185
87FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.23576601
88SMAD4_21799915_ChIP-Seq_A2780_Human1.23495201
89BCAT_22108803_ChIP-Seq_LS180_Human1.22447442
90RING1B_27294783_Chip-Seq_NPCs_Mouse1.22244104
91SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21509409
92CBX2_27304074_Chip-Seq_ESCs_Mouse1.20912276
93TCF4_18268006_ChIP-ChIP_LS174T_Human1.20742232
94TCF4_23295773_ChIP-Seq_U87_Human1.20199826
95WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20076551
96POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19680457
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19284147
98TBX3_20139965_ChIP-Seq_ESCs_Mouse1.18624539
99TBX3_20139965_ChIP-Seq_MESCs_Mouse1.18343599
100P300_19829295_ChIP-Seq_ESCs_Human1.18250908
101SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17955660
102GATA2_21666600_ChIP-Seq_HMVEC_Human1.16154479
103OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15868423
104FUS_26573619_Chip-Seq_HEK293_Human1.15735580
105ARNT_22903824_ChIP-Seq_MCF-7_Human1.15315309
106AHR_22903824_ChIP-Seq_MCF-7_Human1.15156510
107RXR_22108803_ChIP-Seq_LS180_Human1.13684708
108TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12771460
109FOXA2_19822575_ChIP-Seq_HepG2_Human1.12368896
110BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11733346
111FOXA1_25552417_ChIP-Seq_VCAP_Human1.11632527
112RING1B_27294783_Chip-Seq_ESCs_Mouse1.11517169
113STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11228825
114CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11190861
115TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10606266
116Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.10143540
117TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10042875
118POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10042875
119SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09268099
120FOXO3_23340844_ChIP-Seq_DLD1_Human1.09239562
121SA1_22415368_ChIP-Seq_MEFs_Mouse1.08115306
122SOX2_27498859_Chip-Seq_STOMACH_Mouse1.07799192
123EZH2_27294783_Chip-Seq_ESCs_Mouse1.07335767
124SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.07295707
125PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.06624379
126ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06582582
127* GATA2_19941826_ChIP-Seq_K562_Human1.06322241
128GATA1_19941826_ChIP-Seq_K562_Human1.06121606
129SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04569114
130SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03625437
131SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02817886
132TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02095027
133RUNX1_27514584_Chip-Seq_MCF-7_Human1.02074137
134YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00982250
135EWS_26573619_Chip-Seq_HEK293_Human1.00850158
136SMC1_22415368_ChIP-Seq_MEFs_Mouse1.00442029
137STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.99814728
138DROSHA_22980978_ChIP-Seq_HELA_Human0.98986663
139* SMAD3_21741376_ChIP-Seq_EPCs_Human0.98608142
140CLOCK_20551151_ChIP-Seq_293T_Human0.98395458
141NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98014707
142TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.97569719
143TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97388479
144POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96796784
145BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94742265
146BP1_19119308_ChIP-ChIP_Hs578T_Human0.94673945
147GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94233678
148* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94083884
149ZNF274_21170338_ChIP-Seq_K562_Hela0.94029639
150EGR1_19374776_ChIP-ChIP_THP-1_Human0.93336728
151CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92991717
152* GF1_26923725_Chip-Seq_HPCs_Mouse0.92845652
153ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92818296
154KLF5_25053715_ChIP-Seq_YYC3_Human0.92239181
155SMAD3_21741376_ChIP-Seq_HESCs_Human0.91821957
156RUNX2_22187159_ChIP-Seq_PCA_Human0.91003498
157LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88937835
158SMAD4_21741376_ChIP-Seq_EPCs_Human0.87784923
159* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.86925303
160VDR_22108803_ChIP-Seq_LS180_Human0.85302414
161CDX2_22108803_ChIP-Seq_LS180_Human0.84956182

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.07677241
2MP0005503_abnormal_tendon_morphology6.61052054
3MP0005275_abnormal_skin_tensile4.71367988
4MP0003718_maternal_effect3.62318454
5MP0002132_abnormal_respiratory_system3.02954892
6MP0003705_abnormal_hypodermis_morpholog2.94385449
7MP0009250_abnormal_appendicular_skeleto2.78462109
8MP0003279_aneurysm2.74653258
9MP0004272_abnormal_basement_membrane2.68190597
10MP0002653_abnormal_ependyma_morphology2.66435304
11MP0000383_abnormal_hair_follicle2.52853421
12MP0001958_emphysema2.48600998
13MP0005508_abnormal_skeleton_morphology2.47258212
14MP0003385_abnormal_body_wall2.46408257
15MP0010030_abnormal_orbit_morphology2.41083796
16MP0005257_abnormal_intraocular_pressure2.40570037
17MP0009384_cardiac_valve_regurgitation2.36262293
18MP0008875_abnormal_xenobiotic_pharmacok2.28437563
19MP0010678_abnormal_skin_adnexa2.27947021
20MP0002108_abnormal_muscle_morphology2.26710131
21MP0005395_other_phenotype2.25991707
22MP0001299_abnormal_eye_distance/2.22591229
23MP0002938_white_spotting2.22330938
24MP0003122_maternal_imprinting2.18386199
25MP0002396_abnormal_hematopoietic_system2.00932143
26MP0001879_abnormal_lymphatic_vessel1.99421380
27MP0003942_abnormal_urinary_system1.95922585
28MP0006054_spinal_hemorrhage1.92321025
29MP0000428_abnormal_craniofacial_morphol1.91646838
30MP0008057_abnormal_DNA_replication1.91365559
31MP0000049_abnormal_middle_ear1.88112274
32MP0009053_abnormal_anal_canal1.87956572
33MP0000534_abnormal_ureter_morphology1.84885057
34MP0003950_abnormal_plasma_membrane1.79715942
35MP0004134_abnormal_chest_morphology1.77023185
36MP0003755_abnormal_palate_morphology1.75463406
37MP0002282_abnormal_trachea_morphology1.74854224
38MP0003937_abnormal_limbs/digits/tail_de1.71467978
39MP0002249_abnormal_larynx_morphology1.68463079
40MP0000681_abnormal_thyroid_gland1.66728497
41MP0002896_abnormal_bone_mineralization1.65762294
42MP0002932_abnormal_joint_morphology1.61907030
43MP0004782_abnormal_surfactant_physiolog1.60045858
44MP0002295_abnormal_pulmonary_circulatio1.59038756
45MP0002060_abnormal_skin_morphology1.55649262
46MP0005647_abnormal_sex_gland1.53980112
47MP0003935_abnormal_craniofacial_develop1.52946107
48MP0002160_abnormal_reproductive_system1.52632754
49MP0003656_abnormal_erythrocyte_physiolo1.51956600
50MP0000762_abnormal_tongue_morphology1.51469932
51MP0000163_abnormal_cartilage_morphology1.50883629
52MP0005171_absent_coat_pigmentation1.48689420
53MP0000566_synostosis1.48612396
54MP0002115_abnormal_skeleton_extremities1.47984229
55MP0010234_abnormal_vibrissa_follicle1.45787537
56MP0001545_abnormal_hematopoietic_system1.45483898
57MP0005397_hematopoietic_system_phenotyp1.45483898
58MP0006138_congestive_heart_failure1.42230764
59MP0002116_abnormal_craniofacial_bone1.41928495
60MP0002109_abnormal_limb_morphology1.41728524
61MP0008789_abnormal_olfactory_epithelium1.40898932
62MP0005409_darkened_coat_color1.40555203
63MP0000733_abnormal_muscle_development1.38582933
64MP0008995_early_reproductive_senescence1.37660531
65MP0000432_abnormal_head_morphology1.33915224
66MP0002233_abnormal_nose_morphology1.33447947
67MP0003699_abnormal_female_reproductive1.33229454
68MP0001984_abnormal_olfaction1.33204502
69MP0004808_abnormal_hematopoietic_stem1.30881900
70MP0005623_abnormal_meninges_morphology1.30798625
71MP0002877_abnormal_melanocyte_morpholog1.30494587
72MP0000537_abnormal_urethra_morphology1.30350612
73MP0003115_abnormal_respiratory_system1.26582945
74MP0004043_abnormal_pH_regulation1.24047237
75MP0002113_abnormal_skeleton_development1.23573222
76MP0001929_abnormal_gametogenesis1.22052448
77MP0001293_anophthalmia1.21157629
78MP0005367_renal/urinary_system_phenotyp1.21010403
79MP0000516_abnormal_urinary_system1.21010403
80MP0005164_abnormal_response_to1.20570764
81MP0003890_abnormal_embryonic-extraembry1.19362977
82MP0001243_abnormal_dermal_layer1.19268396
83MP0005248_abnormal_Harderian_gland1.17700274
84MP0005187_abnormal_penis_morphology1.16016760
85MP0005023_abnormal_wound_healing1.15580044
86MP0003941_abnormal_skin_development1.15532462
87MP0002177_abnormal_outer_ear1.13201796
88MP0005390_skeleton_phenotype1.12263372
89MP0003828_pulmonary_edema1.11053350
90MP0002168_other_aberrant_phenotype1.06863088
91MP0010368_abnormal_lymphatic_system1.06005034
92MP0005076_abnormal_cell_differentiation1.05516689
93MP0005389_reproductive_system_phenotype1.03392265
94MP0000767_abnormal_smooth_muscle1.02385192
95MP0001270_distended_abdomen1.01678930
96MP0009278_abnormal_bone_marrow1.01168165
97MP0003121_genomic_imprinting1.00547647
98MP0000751_myopathy1.00543106
99MP0000569_abnormal_digit_pigmentation0.99920640
100MP0000462_abnormal_digestive_system0.98003046
101MP0002114_abnormal_axial_skeleton0.96430264
102MP0003566_abnormal_cell_adhesion0.93523676
103MP0003283_abnormal_digestive_organ0.92600973
104MP0001849_ear_inflammation0.92233993
105MP0003091_abnormal_cell_migration0.92096871
106MP0001661_extended_life_span0.91973611
107MP0002089_abnormal_postnatal_growth/wei0.91801335
108MP0010307_abnormal_tumor_latency0.91630230
109MP0001340_abnormal_eyelid_morphology0.89996175
110MP0009115_abnormal_fat_cell0.89372447
111MP0002111_abnormal_tail_morphology0.88181802
112MP0001853_heart_inflammation0.86942405
113MP0003123_paternal_imprinting0.84632513
114MP0002933_joint_inflammation0.84239892
115MP0001177_atelectasis0.84002107
116MP0001119_abnormal_female_reproductive0.83668194
117MP0005499_abnormal_olfactory_system0.82589144
118MP0005394_taste/olfaction_phenotype0.82589144
119MP0003045_fibrosis0.82198448
120MP0003938_abnormal_ear_development0.81376659
121MP0001542_abnormal_bone_strength0.77639531
122MP0001175_abnormal_lung_morphology0.77107653
123MP0010352_gastrointestinal_tract_polyps0.76068196
124MP0003959_abnormal_lean_body0.75650220
125MP0005595_abnormal_vascular_smooth0.73983581
126MP0002998_abnormal_bone_remodeling0.73479286
127MP0001346_abnormal_lacrimal_gland0.73292996
128MP0009703_decreased_birth_body0.73070201
129MP0000579_abnormal_nail_morphology0.73018497
130MP0000613_abnormal_salivary_gland0.72992484
131MP0002161_abnormal_fertility/fecundity0.71297836
132MP0002092_abnormal_eye_morphology0.71168592
133MP0005666_abnormal_adipose_tissue0.70042715
134MP0002925_abnormal_cardiovascular_devel0.70040684
135MP0005388_respiratory_system_phenotype0.69065447
136MP0002133_abnormal_respiratory_system0.69065447
137MP0000266_abnormal_heart_morphology0.68514489
138MP0001851_eye_inflammation0.67103759
139MP0000013_abnormal_adipose_tissue0.66473485
140MP0002009_preneoplasia0.66357141
141MP0000653_abnormal_sex_gland0.66204677
142MP0002405_respiratory_system_inflammati0.66033146
143MP0001784_abnormal_fluid_regulation0.64790138
144MP0003795_abnormal_bone_structure0.64647104
145MP0000003_abnormal_adipose_tissue0.64646795
146MP0002128_abnormal_blood_circulation0.64481200
147MP0005220_abnormal_exocrine_pancreas0.63582275
148MP0004484_altered_response_of0.62670546
149MP0002697_abnormal_eye_size0.62393866
150MP0003943_abnormal_hepatobiliary_system0.62163502
151MP0001614_abnormal_blood_vessel0.62018270
152MP0004145_abnormal_muscle_electrophysio0.61237557
153MP0002098_abnormal_vibrissa_morphology0.61039432
154MP0009780_abnormal_chondrocyte_physiolo0.60482457
155MP0001915_intracranial_hemorrhage0.59815442
156MP0002084_abnormal_developmental_patter0.59088816
157MP0004197_abnormal_fetal_growth/weight/0.58877208
158MP0005369_muscle_phenotype0.58379172

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)9.66430876
2Dynein arm defect of respiratory motile cilia (HP:0012255)9.66430876
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.49118260
4Abnormal ciliary motility (HP:0012262)9.03394874
5Abnormal respiratory motile cilium morphology (HP:0005938)8.99857289
6Abnormal respiratory epithelium morphology (HP:0012253)8.99857289
7Abnormal respiratory motile cilium physiology (HP:0012261)8.75960384
8Rhinitis (HP:0012384)7.90933649
9Protrusio acetabuli (HP:0003179)7.07996153
10Chronic bronchitis (HP:0004469)5.74587955
11Premature rupture of membranes (HP:0001788)5.60552294
12Bronchiectasis (HP:0002110)5.55188725
13Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)5.32672298
14Short 4th metacarpal (HP:0010044)5.32672298
15Shallow orbits (HP:0000586)5.18875374
16Broad metatarsal (HP:0001783)5.07514394
17Nasal polyposis (HP:0100582)4.64877033
18Ankle contracture (HP:0006466)4.43506153
19Abnormality of the nasal mucosa (HP:0000433)4.23704651
20Infertility (HP:0000789)4.17287884
21Aortic dissection (HP:0002647)4.02289798
22Abnormality of the 4th metacarpal (HP:0010012)3.97803468
23Soft skin (HP:0000977)3.66468023
24Male infertility (HP:0003251)3.51977261
25Atrophic scars (HP:0001075)3.51341349
26Abnormality of the parietal bone (HP:0002696)3.47763732
27Peritonitis (HP:0002586)3.45780963
28Microglossia (HP:0000171)3.44690034
29Follicular hyperkeratosis (HP:0007502)3.43146050
30Bronchitis (HP:0012387)3.42296727
31Cervical subluxation (HP:0003308)3.18705656
32Bladder diverticulum (HP:0000015)3.15278717
33Aortic aneurysm (HP:0004942)3.14788448
34Tubulointerstitial nephritis (HP:0001970)3.13466655
35Mitral valve prolapse (HP:0001634)3.09467068
36Dilatation of the ascending aorta (HP:0005111)3.08103925
37Genu recurvatum (HP:0002816)3.04175502
38Recurrent sinusitis (HP:0011108)3.01649577
39Coronal craniosynostosis (HP:0004440)3.00986382
40Wrist flexion contracture (HP:0001239)2.98076921
41Fragile skin (HP:0001030)2.94449309
42Type 1 muscle fiber predominance (HP:0003803)2.90896808
43Wide anterior fontanel (HP:0000260)2.88529722
44Neonatal short-limb short stature (HP:0008921)2.88177518
45Bell-shaped thorax (HP:0001591)2.87660642
46Midline defect of the nose (HP:0004122)2.87207956
47Abnormality of dentin (HP:0010299)2.79603766
48Infantile muscular hypotonia (HP:0008947)2.79198183
49Recurrent otitis media (HP:0000403)2.77900814
50Cerebral aneurysm (HP:0004944)2.77361666
51Mesomelia (HP:0003027)2.76943840
52Slender build (HP:0001533)2.75977114
53Chronic sinusitis (HP:0011109)2.69769653
54Atelectasis (HP:0100750)2.65045854
55Chronic hepatic failure (HP:0100626)2.63955215
56Hyperactive renin-angiotensin system (HP:0000841)2.63206365
57Hyperextensible skin (HP:0000974)2.58281057
58Trigonocephaly (HP:0000243)2.56561925
59Biconcave vertebral bodies (HP:0004586)2.53967572
60Blue sclerae (HP:0000592)2.53914199
61Decreased circulating renin level (HP:0003351)2.51431356
62Wormian bones (HP:0002645)2.47918397
63Occipital encephalocele (HP:0002085)2.46550404
64Absent frontal sinuses (HP:0002688)2.45220242
65Overgrowth (HP:0001548)2.43248555
66Chronic otitis media (HP:0000389)2.37024228
67Joint laxity (HP:0001388)2.34958962
68Spinal cord lesions (HP:0100561)2.34691387
69Syringomyelia (HP:0003396)2.34691387
70Spinal rigidity (HP:0003306)2.33940302
71Broad long bones (HP:0005622)2.30283775
72Deviation of the hallux (HP:0010051)2.29915098
73Narrow palate (HP:0000189)2.29343280
74Vertebral compression fractures (HP:0002953)2.28939188
75Broad ribs (HP:0000885)2.27551806
76Broad toe (HP:0001837)2.26834294
77Hypoplasia of the maxilla (HP:0000327)2.25874844
78Buphthalmos (HP:0000557)2.25422186
79Lip pit (HP:0100267)2.24670846
80Bowel diverticulosis (HP:0005222)2.20707999
81Obstructive sleep apnea (HP:0002870)2.20042240
82Abnormality of the distal phalanx of the thumb (HP:0009617)2.16617491
83Cystic liver disease (HP:0006706)2.16595552
84Hyperkalemia (HP:0002153)2.16160616
85Turricephaly (HP:0000262)2.12827927
86Hypoplasia of the fovea (HP:0007750)2.12484307
87Aplasia/Hypoplasia of the fovea (HP:0008060)2.12484307
88Vitreoretinal degeneration (HP:0000655)2.12254545
89Hallux valgus (HP:0001822)2.12223659
90Pancreatic fibrosis (HP:0100732)2.11925593
91Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.11307583
92Spondylolisthesis (HP:0003302)2.11108628
93Hypoplastic ischia (HP:0003175)2.10561932
94Broad hallux (HP:0010055)2.06848769
95Protruding ear (HP:0000411)2.05492549
96Asymmetry of the thorax (HP:0001555)2.05390324
97Limited hip movement (HP:0008800)2.04956834
98Decreased skull ossification (HP:0004331)2.02847476
99Abnormality of the fingertips (HP:0001211)2.00870617
100Ectopia lentis (HP:0001083)2.00353980
101Narrow nasal bridge (HP:0000446)1.99727843
102Disproportionate tall stature (HP:0001519)1.99294179
103Broad phalanx (HP:0006009)1.98613796
104Mildly elevated creatine phosphokinase (HP:0008180)1.96648768
105Elbow flexion contracture (HP:0002987)1.95837812
106Interstitial pulmonary disease (HP:0006530)1.95660508
107Vascular tortuosity (HP:0004948)1.94740073
108Tubulointerstitial abnormality (HP:0001969)1.94543010
109Osteoarthritis (HP:0002758)1.94226090
110Abnormality of the phalanges of the hallux (HP:0010057)1.91719980
111Increased variability in muscle fiber diameter (HP:0003557)1.91639833
112Morphological abnormality of the middle ear (HP:0008609)1.91011577
113Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.89902366
114Abnormality of the ischium (HP:0003174)1.89687250
115Increased number of teeth (HP:0011069)1.89216705
116Abnormality of the nasal septum (HP:0000419)1.88917235
117Anteriorly placed anus (HP:0001545)1.88561150
118Hip contracture (HP:0003273)1.88559164
119Glucose intolerance (HP:0000833)1.88556659
120Camptodactyly of toe (HP:0001836)1.87876241
121Hypoventilation (HP:0002791)1.87615554
122Abnormality of midbrain morphology (HP:0002418)1.86687309
123Molar tooth sign on MRI (HP:0002419)1.86687309
124Thin bony cortex (HP:0002753)1.86412663
125Abnormality of the nasolacrimal system (HP:0000614)1.85731732
126Hepatoblastoma (HP:0002884)1.85391792
127Cutaneous finger syndactyly (HP:0010554)1.85128793
128Anterior segment dysgenesis (HP:0007700)1.83417514
129Nephronophthisis (HP:0000090)1.82732183
130Mitral regurgitation (HP:0001653)1.82620471
131Recurrent bronchitis (HP:0002837)1.82596508
132Broad thumb (HP:0011304)1.81450035
133Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.80372261
134Wide cranial sutures (HP:0010537)1.80182584
135Delayed cranial suture closure (HP:0000270)1.80041495
136Abnormality of the acetabulum (HP:0003170)1.79744078
137Nasolacrimal duct obstruction (HP:0000579)1.79712450
138Exostoses (HP:0100777)1.78111079
139Abnormality of the peritoneum (HP:0002585)1.77588669
140Increased connective tissue (HP:0009025)1.77558009
141Broad finger (HP:0001500)1.77491581
142Papillary thyroid carcinoma (HP:0002895)1.77408515
143Postaxial foot polydactyly (HP:0001830)1.77266295
144Striae distensae (HP:0001065)1.75531941
145Arterial tortuosity (HP:0005116)1.75407523
146True hermaphroditism (HP:0010459)1.74161131
147Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.71028486
148Abnormality of the fovea (HP:0000493)1.70662826
149Cone-rod dystrophy (HP:0000548)1.70259505
150Acute myeloid leukemia (HP:0004808)1.69745813
151Aplasia/Hypoplasia of the tongue (HP:0010295)1.69289048
152Flat acetabular roof (HP:0003180)1.67756945
153Abnormality of the renal medulla (HP:0100957)1.64567610
154Dysmetric saccades (HP:0000641)1.62686183
155Pancreatic cysts (HP:0001737)1.58948813
156Absent rod-and cone-mediated responses on ERG (HP:0007688)1.56579980
157Muscle fiber splitting (HP:0003555)1.52409438
158Abnormality of the anterior chamber (HP:0000593)1.50440843
159Carpal bone hypoplasia (HP:0001498)1.50183560
160Spinal cord compression (HP:0002176)1.45656528
161Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.42162109
162Congenital hepatic fibrosis (HP:0002612)1.41668516
163Abnormality of the frontal sinuses (HP:0002687)1.41344832
164Aplasia/Hypoplasia of the macula (HP:0008059)1.39730338
165Hypoplasia of the odontoid process (HP:0003311)1.39085312
166Tubulointerstitial fibrosis (HP:0005576)1.38715902
167Hypergonadotropic hypogonadism (HP:0000815)1.38153894
168Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.36399563
169Complement deficiency (HP:0004431)1.35478696
170Tubular atrophy (HP:0000092)1.33212195
171Hirsutism (HP:0001007)1.32160053
172Hyperaldosteronism (HP:0000859)1.30972019
173Abnormality of molar morphology (HP:0011070)1.30928092
174Abnormality of molar (HP:0011077)1.30928092
175Portal hypertension (HP:0001409)1.29141437
176Central scotoma (HP:0000603)1.25342216
177Median cleft lip (HP:0000161)1.24616532
178Aplasia/Hypoplasia affecting the retina (HP:0008061)1.23807258
179Aplasia of the musculature (HP:0100854)1.22614965
180Abnormality of permanent molar morphology (HP:0011071)1.21472009
181Abnormality of the dental root (HP:0006486)1.21472009
182Taurodontia (HP:0000679)1.21472009
183Renovascular hypertension (HP:0100817)1.21330331
184Chin dimple (HP:0010751)1.21137206

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK156.21765873
2DDR25.98780498
3EPHA35.86091047
4LATS14.39364086
5EEF2K4.09189550
6PDGFRA3.98588317
7SIK13.92083840
8FGFR23.03539232
9LATS22.43244728
10EPHB22.37499206
11TTN2.16744740
12FGFR12.05133085
13CAMK1G1.83205988
14RIPK11.80267308
15MAPKAPK31.78293226
16CAMK1D1.75615902
17FER1.72779641
18DMPK1.71814788
19NEK61.71050531
20STK31.67262746
21PDGFRB1.61913016
22PIK3CA1.60173479
23TRIB31.59931812
24TGFBR21.49169886
25TTK1.47969242
26MST41.47201151
27STK241.41210100
28FRK1.40802783
29MAP3K71.38485359
30CDK121.35688129
31MELK1.35066384
32MAP3K131.29423872
33TEC1.29302656
34BMX1.28985162
35PTK21.27301240
36RPS6KB21.25811939
37NUAK11.22456675
38PLK21.21565921
39MTOR1.16201507
40PAK21.14655233
41TIE11.14093028
42NEK91.10349166
43TAOK31.06521376
44WNK10.99868979
45STK100.96910743
46FGFR30.95387066
47ICK0.94222941
48MET0.93151437
49PTK2B0.91426720
50ROCK10.90111016
51ERBB30.89755007
52MOS0.89432770
53MAP3K20.89132563
54PAK30.88694048
55NME10.87407088
56PDK20.86655726
57STK380.85336844
58ADRBK10.81726233
59PDPK10.81664020
60CSNK1A1L0.80950335
61SMG10.80600303
62PKN20.79596851
63JAK10.78407822
64PRKCH0.76840834
65MAPK110.75365589
66MAP3K60.75028098
67PTK60.73534395
68ZAP700.72626043
69NLK0.70866775
70CLK10.66660575
71ERBB20.66230911
72PRKCE0.65694892
73CASK0.63402970
74NTRK10.63328488
75RPS6KA20.62997077
76ERN10.61198107
77BRSK20.60751450
78RET0.60470412
79HIPK20.59879603
80MAPK120.58595837
81BRD40.58573519
82AKT30.58178959
83CAMK40.58075475
84PRKD20.57712180
85INSR0.57121644
86CDK60.56823595
87ROCK20.55112694
88EIF2AK20.55043906
89PIK3CG0.54691053
90CSNK1G10.54014426
91CHEK10.51915571
92MAPK10.51167509
93CDC42BPA0.50927260
94EPHB10.49055169
95AURKA0.48888309
96BTK0.48561796
97TRPM70.47820463
98TGFBR10.47483409
99FGFR40.45580403
100RPS6KB10.45475512
101PRPF4B0.45372360
102MYLK0.43926751
103SRC0.43683107
104IGF1R0.43585386
105PAK40.42438505
106MARK20.42169074
107PRKD30.41608926
108PRKD10.39835003
109MKNK10.39128378
110PDK10.38862794
111PLK30.38270126
112STK38L0.37981810
113CDK20.37767723
114RPS6KA40.37619735
115IRAK10.36978473
116MAP2K20.36926103
117GRK10.36857160
118CDK80.36349176
119ABL10.36155062
120MAP2K10.35960149
121MAPK70.35951863
122MKNK20.35071008
123MAPK80.34366901
124PRKAA10.33612415
125SGK10.32982324
126KIT0.32627943
127CHUK0.32544618
128GSK3A0.32361752
129MAP3K100.31979703
130PRKAA20.30224269
131BMPR1B0.29966130
132PNCK0.27897860
133FYN0.26850971
134LRRK20.24776210
135MAPK100.24492265
136CDK70.24234441
137CDK90.23919677
138MAPK140.23875193
139CSF1R0.23727015
140DYRK20.23585008
141FLT30.22658794
142PRKCG0.21819306
143MAPK30.20840522
144MAPKAPK50.20431360
145MAPK130.20308207
146CSNK1A10.19740742

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.19211001
2Basal cell carcinoma_Homo sapiens_hsa052173.43941713
3Hedgehog signaling pathway_Homo sapiens_hsa043403.12663444
4Protein digestion and absorption_Homo sapiens_hsa049742.84360682
5Focal adhesion_Homo sapiens_hsa045102.70647288
6Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.35988373
7Histidine metabolism_Homo sapiens_hsa003402.27566409
8Adherens junction_Homo sapiens_hsa045202.27352909
9TGF-beta signaling pathway_Homo sapiens_hsa043502.24165955
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.23217380
11Proteoglycans in cancer_Homo sapiens_hsa052052.16757222
12Glycosaminoglycan degradation_Homo sapiens_hsa005312.11906773
13Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.05571126
14Wnt signaling pathway_Homo sapiens_hsa043102.04341236
15Hippo signaling pathway_Homo sapiens_hsa043902.02644643
16ABC transporters_Homo sapiens_hsa020101.93505981
17Melanoma_Homo sapiens_hsa052181.83950710
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.83824101
19Axon guidance_Homo sapiens_hsa043601.82356861
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.78279993
21AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.78140759
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.77663729
23Amoebiasis_Homo sapiens_hsa051461.77456549
24MicroRNAs in cancer_Homo sapiens_hsa052061.77167664
25Phenylalanine metabolism_Homo sapiens_hsa003601.74950704
26Dilated cardiomyopathy_Homo sapiens_hsa054141.73418974
27PI3K-Akt signaling pathway_Homo sapiens_hsa041511.73227280
28Tyrosine metabolism_Homo sapiens_hsa003501.71244492
29Prostate cancer_Homo sapiens_hsa052151.63876636
30Chemical carcinogenesis_Homo sapiens_hsa052041.62506017
31Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.62085638
32Malaria_Homo sapiens_hsa051441.61763831
33Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.59616621
34Pathways in cancer_Homo sapiens_hsa052001.52677232
35Sphingolipid metabolism_Homo sapiens_hsa006001.46673407
36Small cell lung cancer_Homo sapiens_hsa052221.40070949
37Melanogenesis_Homo sapiens_hsa049161.36149363
38Other glycan degradation_Homo sapiens_hsa005111.33502810
39Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.28904661
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.28607628
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.24273212
42Glioma_Homo sapiens_hsa052141.23490930
43Acute myeloid leukemia_Homo sapiens_hsa052211.22565955
44Regulation of actin cytoskeleton_Homo sapiens_hsa048101.16079463
45Colorectal cancer_Homo sapiens_hsa052101.16072376
46Chronic myeloid leukemia_Homo sapiens_hsa052201.14565989
47Circadian rhythm_Homo sapiens_hsa047101.12000970
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.10734994
49Rap1 signaling pathway_Homo sapiens_hsa040151.08837117
50Renin-angiotensin system_Homo sapiens_hsa046141.07616748
51Bladder cancer_Homo sapiens_hsa052191.04799659
52Viral myocarditis_Homo sapiens_hsa054161.04760720
53Inositol phosphate metabolism_Homo sapiens_hsa005621.03121161
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.96201724
55Estrogen signaling pathway_Homo sapiens_hsa049150.93793150
56Renin secretion_Homo sapiens_hsa049240.91460533
57Lysine degradation_Homo sapiens_hsa003100.90950298
58Platelet activation_Homo sapiens_hsa046110.90770829
59Pancreatic cancer_Homo sapiens_hsa052120.90704123
60Thyroid cancer_Homo sapiens_hsa052160.90123856
61Gap junction_Homo sapiens_hsa045400.89737070
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88541990
63beta-Alanine metabolism_Homo sapiens_hsa004100.86821002
64Salivary secretion_Homo sapiens_hsa049700.86432984
65Renal cell carcinoma_Homo sapiens_hsa052110.85308643
66HTLV-I infection_Homo sapiens_hsa051660.85288322
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85106378
68Jak-STAT signaling pathway_Homo sapiens_hsa046300.84606957
69Endometrial cancer_Homo sapiens_hsa052130.82538721
70Complement and coagulation cascades_Homo sapiens_hsa046100.82044368
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.79777299
72cAMP signaling pathway_Homo sapiens_hsa040240.78512689
73Ras signaling pathway_Homo sapiens_hsa040140.78387750
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77887884
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77690161
76Ovarian steroidogenesis_Homo sapiens_hsa049130.76385161
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76235195
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.76079329
79GnRH signaling pathway_Homo sapiens_hsa049120.74823536
80Notch signaling pathway_Homo sapiens_hsa043300.74401636
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74250650
82Cocaine addiction_Homo sapiens_hsa050300.74093891
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.73781184
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73416741
85Non-small cell lung cancer_Homo sapiens_hsa052230.72661345
86MAPK signaling pathway_Homo sapiens_hsa040100.72299518
87Taste transduction_Homo sapiens_hsa047420.71985832
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70113215
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69575602
90Linoleic acid metabolism_Homo sapiens_hsa005910.68151744
91Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67820106
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66825988
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.66633556
94mTOR signaling pathway_Homo sapiens_hsa041500.65097365
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64967174
96Toxoplasmosis_Homo sapiens_hsa051450.64793791
97Tight junction_Homo sapiens_hsa045300.64588307
98TNF signaling pathway_Homo sapiens_hsa046680.64369303
99Thyroid hormone synthesis_Homo sapiens_hsa049180.64216286
100ErbB signaling pathway_Homo sapiens_hsa040120.64037627
101Type II diabetes mellitus_Homo sapiens_hsa049300.62786809
102Insulin resistance_Homo sapiens_hsa049310.62065695
103Amphetamine addiction_Homo sapiens_hsa050310.62019599
104AMPK signaling pathway_Homo sapiens_hsa041520.61953925
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60530046
106FoxO signaling pathway_Homo sapiens_hsa040680.60464959
107Caffeine metabolism_Homo sapiens_hsa002320.58867581
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58142862
109Retinol metabolism_Homo sapiens_hsa008300.57997358
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.57857426
111Hepatitis B_Homo sapiens_hsa051610.55830762
112Long-term depression_Homo sapiens_hsa047300.53449150
113Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53431171
114Cholinergic synapse_Homo sapiens_hsa047250.53137953
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.53103883
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49726246
117Oxytocin signaling pathway_Homo sapiens_hsa049210.49329027
118Choline metabolism in cancer_Homo sapiens_hsa052310.48921615
119Olfactory transduction_Homo sapiens_hsa047400.48507227
120Circadian entrainment_Homo sapiens_hsa047130.48327662
121Hematopoietic cell lineage_Homo sapiens_hsa046400.47125741
122B cell receptor signaling pathway_Homo sapiens_hsa046620.46368703
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.45701985
124Endocytosis_Homo sapiens_hsa041440.45473963
125Prolactin signaling pathway_Homo sapiens_hsa049170.44825276
126Steroid hormone biosynthesis_Homo sapiens_hsa001400.44748652
127p53 signaling pathway_Homo sapiens_hsa041150.43902357
128Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43844888
129Insulin signaling pathway_Homo sapiens_hsa049100.43669490
130Dopaminergic synapse_Homo sapiens_hsa047280.41204839
131Cell cycle_Homo sapiens_hsa041100.40267536
132Dorso-ventral axis formation_Homo sapiens_hsa043200.39780331
133Glucagon signaling pathway_Homo sapiens_hsa049220.39699574
134Viral carcinogenesis_Homo sapiens_hsa052030.39372639
135Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39018733
136Calcium signaling pathway_Homo sapiens_hsa040200.38899496

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