IGSF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the immunoglobulin-like domain-containing superfamily. Proteins in this superfamily contain varying numbers of immunoglobulin-like domains and are thought to participate in the regulation of interactions between cells. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma lipoprotein particle assembly (GO:0034377)7.31835202
2very-low-density lipoprotein particle assembly (GO:0034379)7.16278777
3alanine transport (GO:0032328)6.62738813
4regulation of penile erection (GO:0060405)6.43253556
5protein-lipid complex assembly (GO:0065005)6.28885147
6intestinal cholesterol absorption (GO:0030299)6.13791911
7peptidyl-glutamic acid carboxylation (GO:0017187)5.98320053
8protein carboxylation (GO:0018214)5.98320053
9regulation of cholesterol esterification (GO:0010872)5.93796710
10high-density lipoprotein particle remodeling (GO:0034375)5.81665824
11negative regulation of fibrinolysis (GO:0051918)5.76759095
12protein-lipid complex remodeling (GO:0034368)5.62512828
13macromolecular complex remodeling (GO:0034367)5.62512828
14plasma lipoprotein particle remodeling (GO:0034369)5.62512828
15reverse cholesterol transport (GO:0043691)5.60332508
16cholesterol efflux (GO:0033344)5.60238560
17proline transport (GO:0015824)5.50117672
18plasma lipoprotein particle organization (GO:0071827)5.24988588
19cell communication by electrical coupling (GO:0010644)5.22599147
20regulation of fibrinolysis (GO:0051917)5.22370074
21cGMP-mediated signaling (GO:0019934)5.12735784
22regulation of fever generation (GO:0031620)5.00104804
23L-serine transport (GO:0015825)4.89591509
24protein-lipid complex subunit organization (GO:0071825)4.81370171
25plasma lipoprotein particle clearance (GO:0034381)4.78536383
26vascular smooth muscle contraction (GO:0014829)4.75682991
27regulation of protein activation cascade (GO:2000257)4.65152804
28cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.64781840
29triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.55682884
30gamma-aminobutyric acid transport (GO:0015812)4.55358786
31regulation of heat generation (GO:0031650)4.54932551
32positive regulation of renal sodium excretion (GO:0035815)4.52109814
33regulation of complement activation (GO:0030449)4.50941807
34blood coagulation, intrinsic pathway (GO:0007597)4.43768565
35regulation of apoptotic cell clearance (GO:2000425)4.38125572
36cellular potassium ion homeostasis (GO:0030007)4.31626421
37phospholipid efflux (GO:0033700)4.26510619
38regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.26319762
39negative regulation of adenylate cyclase activity (GO:0007194)4.19752246
40regulation of bile acid biosynthetic process (GO:0070857)4.11767669
41negative regulation of sterol transport (GO:0032372)4.08156001
42negative regulation of cholesterol transport (GO:0032375)4.08156001
43serine transport (GO:0032329)4.07101993
44intestinal absorption (GO:0050892)4.01686405
45cellular sodium ion homeostasis (GO:0006883)3.98938747
46regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.98841417
47negative regulation of cyclase activity (GO:0031280)3.98416691
48sodium ion export (GO:0071436)3.97167303
49erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.87951661
50L-phenylalanine catabolic process (GO:0006559)3.87951661
51negative regulation of lyase activity (GO:0051350)3.82932225
52potassium ion import (GO:0010107)3.81293187
53enteric nervous system development (GO:0048484)3.79828365
54COPI coating of Golgi vesicle (GO:0048205)3.78602908
55Golgi transport vesicle coating (GO:0048200)3.78602908
56regulation of cholesterol homeostasis (GO:2000188)3.77109907
57phasic smooth muscle contraction (GO:0014821)3.76954425
58positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.75981993
59membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.71003300
60regulation of non-canonical Wnt signaling pathway (GO:2000050)3.70024190
61atrial cardiac muscle cell action potential (GO:0086014)3.65174593
62regulation of plasminogen activation (GO:0010755)3.64879338
63positive regulation of hormone metabolic process (GO:0032352)3.60373079
64cholesterol homeostasis (GO:0042632)3.60312911
65neurotransmitter uptake (GO:0001504)3.57031116
66regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.55583805
67sterol homeostasis (GO:0055092)3.54800422
68cholesterol biosynthetic process (GO:0006695)3.52436525
69G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.51445710
70cholesterol transport (GO:0030301)3.50689013
71sterol transport (GO:0015918)3.50689013
72negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.50100722
73nitric oxide mediated signal transduction (GO:0007263)3.47757637
74negative regulation of cAMP biosynthetic process (GO:0030818)3.46890580
75neurotransmitter-gated ion channel clustering (GO:0072578)3.44207577
76membrane repolarization (GO:0086009)3.43211108
77regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.42796544
78lipoprotein metabolic process (GO:0042157)3.41964340
79regulation of membrane repolarization (GO:0060306)3.39616260
80erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.38521810
81L-phenylalanine metabolic process (GO:0006558)3.38521810
82regulation of cell maturation (GO:1903429)3.36372711
83regulation of short-term neuronal synaptic plasticity (GO:0048172)3.36079698
84proline metabolic process (GO:0006560)3.34493648
85artery smooth muscle contraction (GO:0014824)3.34403814
86negative regulation of cyclic nucleotide biosynthetic process (GO:0030803)3.33165840
87peptidyl-glutamic acid modification (GO:0018200)3.33066662
88water-soluble vitamin biosynthetic process (GO:0042364)3.32400412
89regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.29861152
90regulation of renal sodium excretion (GO:0035813)3.29787246
91C4-dicarboxylate transport (GO:0015740)3.25135490
92peptide hormone processing (GO:0016486)3.25106911
93triglyceride homeostasis (GO:0070328)3.25102798
94acylglycerol homeostasis (GO:0055090)3.25102798
95positive regulation of potassium ion transmembrane transport (GO:1901381)3.23113627
96negative regulation of sodium ion transport (GO:0010766)3.22298099
97vasodilation (GO:0042311)3.22175757
98regulation of cholesterol biosynthetic process (GO:0045540)3.22054411
99negative regulation of potassium ion transmembrane transport (GO:1901380)3.21955514
100regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.20983260
101positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.20087321
102phosphate ion homeostasis (GO:0055062)3.19076338
103trivalent inorganic anion homeostasis (GO:0072506)3.19076338
104negative regulation of cytosolic calcium ion concentration (GO:0051481)3.18309046
105negative regulation of protein activation cascade (GO:2000258)3.18287019
106negative regulation of lipase activity (GO:0060192)3.16929910
107embryonic retina morphogenesis in camera-type eye (GO:0060059)3.15231770
108diacylglycerol metabolic process (GO:0046339)3.14851899
109regulation of beta-amyloid formation (GO:1902003)3.14143631
110positive regulation of steroid metabolic process (GO:0045940)3.14110364
111membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.13972213
112negative regulation of cAMP metabolic process (GO:0030815)3.13888532
113potassium ion homeostasis (GO:0055075)3.13851315
114transepithelial transport (GO:0070633)3.13528106
115negative regulation of tissue remodeling (GO:0034104)3.12735853
116low-density lipoprotein particle remodeling (GO:0034374)3.12260599
117negative regulation of purine nucleotide biosynthetic process (GO:1900372)3.11203953
118negative regulation of nucleotide biosynthetic process (GO:0030809)3.11203953
119maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.10989199
120sterol biosynthetic process (GO:0016126)3.10263592
121lung epithelium development (GO:0060428)3.08887494
122regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.08393509
123positive regulation of insulin secretion (GO:0032024)3.06621094
124negative regulation of cyclic nucleotide metabolic process (GO:0030800)3.02283115
125drinking behavior (GO:0042756)2.98097425
126cyclic-nucleotide-mediated signaling (GO:0019935)2.96825964
127glutamate metabolic process (GO:0006536)2.95184477
128synaptic vesicle maturation (GO:0016188)2.95089483
129response to dietary excess (GO:0002021)2.94264886
130positive regulation of amino acid transport (GO:0051957)2.93429708
131positive regulation of fatty acid biosynthetic process (GO:0045723)2.93363532
132hyperosmotic salinity response (GO:0042538)2.92324184
133sodium ion homeostasis (GO:0055078)2.92106132
134calcium-mediated signaling using intracellular calcium source (GO:0035584)2.91816451
135negative regulation of norepinephrine secretion (GO:0010700)2.90519164
136regulation of adenylate cyclase activity (GO:0045761)2.90516217
137positive regulation of dendritic spine morphogenesis (GO:0061003)2.90360804
138lipid homeostasis (GO:0055088)2.89320868
139cell communication involved in cardiac conduction (GO:0086065)2.88939638
140membrane repolarization during action potential (GO:0086011)2.88046438
141regulation of glucokinase activity (GO:0033131)2.87856103
142regulation of hexokinase activity (GO:1903299)2.87856103
143regulation of type B pancreatic cell apoptotic process (GO:2000674)2.87517639
144neurotransmitter secretion (GO:0007269)2.86132662
145L-alpha-amino acid transmembrane transport (GO:1902475)2.85805008
146endocrine pancreas development (GO:0031018)2.85790434
147protein maturation by protein folding (GO:0022417)2.85401991
148positive regulation of potassium ion transport (GO:0043268)2.83522609
149G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.83129536
150response to auditory stimulus (GO:0010996)2.82625030
151insulin secretion (GO:0030073)2.82306413
152positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.81879034
153positive regulation of hormone biosynthetic process (GO:0046886)2.81623466
154amino acid import (GO:0043090)2.81304057
155regulation of amyloid precursor protein catabolic process (GO:1902991)2.81299792
156positive regulation of urine volume (GO:0035810)2.80613097
157neuromuscular process controlling posture (GO:0050884)2.80182210
158L-ascorbic acid metabolic process (GO:0019852)2.80016412
159potassium ion export (GO:0071435)2.79714481
160locomotory exploration behavior (GO:0035641)2.79237023
161regulation of norepinephrine secretion (GO:0014061)2.78944417
162cerebellar granule cell differentiation (GO:0021707)2.78162436
163cellular response to cholesterol (GO:0071397)2.77904042
164regulation of insulin secretion (GO:0050796)2.76944191
165peristalsis (GO:0030432)2.76609258
166regulation of synaptic vesicle exocytosis (GO:2000300)2.74910238
167cellular zinc ion homeostasis (GO:0006882)2.74808908
168renal tubule morphogenesis (GO:0061333)2.73138716
169vasoconstriction (GO:0042310)2.72428620
170fatty acid homeostasis (GO:0055089)2.72174623
171melanocyte differentiation (GO:0030318)2.71191895
172positive regulation of lipoprotein lipase activity (GO:0051006)2.70038746
173positive regulation of triglyceride lipase activity (GO:0061365)2.70038746
174neurotransmitter transport (GO:0006836)2.69926754
175regulation of long-term neuronal synaptic plasticity (GO:0048169)2.68481359
176regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.67967988
177mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.67252523
178nephron tubule morphogenesis (GO:0072078)2.67107184
179nephron epithelium morphogenesis (GO:0072088)2.67107184
180regulation of excretion (GO:0044062)2.66401727
181tonic smooth muscle contraction (GO:0014820)2.65724003
182detection of calcium ion (GO:0005513)2.65595296
183exocrine pancreas development (GO:0031017)2.64680117
184phospholipid homeostasis (GO:0055091)2.62809574
185serine family amino acid catabolic process (GO:0009071)2.61730900
186aromatic amino acid family catabolic process (GO:0009074)2.60397377
187positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.59891221
188anion homeostasis (GO:0055081)2.54994251
189renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.54503852
190cellular anion homeostasis (GO:0030002)2.52905692
191proline biosynthetic process (GO:0006561)2.51512636
192regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.49693824
193response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.47737025

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.62269755
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.26122286
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.41525388
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.90046507
5FOXA2_19822575_ChIP-Seq_HepG2_Human3.08006880
6GBX2_23144817_ChIP-Seq_PC3_Human2.95523006
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.93485493
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.88468164
9CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.78339885
10REST_21632747_ChIP-Seq_MESCs_Mouse2.75843161
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.64122862
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.56456640
13IKZF1_21737484_ChIP-ChIP_HCT116_Human2.53333194
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.52933093
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.42217787
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.41844230
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.37412705
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.36224911
19* HNF4A_19822575_ChIP-Seq_HepG2_Human2.35437761
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.31688377
21JARID2_20064375_ChIP-Seq_MESCs_Mouse2.25806332
22LXR_22158963_ChIP-Seq_LIVER_Mouse2.22616858
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.20667279
24EGR1_23403033_ChIP-Seq_LIVER_Mouse2.19174838
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.19010326
26JARID2_20075857_ChIP-Seq_MESCs_Mouse2.18393124
27CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.16487146
28EZH2_27294783_Chip-Seq_ESCs_Mouse2.13473697
29EZH2_27304074_Chip-Seq_ESCs_Mouse2.10313223
30PPARA_22158963_ChIP-Seq_LIVER_Mouse2.10099979
31EZH2_18974828_ChIP-Seq_MESCs_Mouse2.05983213
32RNF2_18974828_ChIP-Seq_MESCs_Mouse2.05983213
33CTBP2_25329375_ChIP-Seq_LNCAP_Human2.02359929
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.01573815
35EED_16625203_ChIP-ChIP_MESCs_Mouse2.00264162
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.90716450
37DROSHA_22980978_ChIP-Seq_HELA_Human1.87835566
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.85185898
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.84964608
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.75745321
41NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.73567076
42FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.72599336
43ESR1_15608294_ChIP-ChIP_MCF-7_Human1.71216844
44RARB_27405468_Chip-Seq_BRAIN_Mouse1.68497802
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.64326318
46HIF1A_21447827_ChIP-Seq_MCF-7_Human1.62956207
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.52035327
48NR3C1_23031785_ChIP-Seq_PC12_Mouse1.50947435
49ZNF274_21170338_ChIP-Seq_K562_Hela1.50432258
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48403042
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.47330938
52PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.44595178
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44188720
54NR3C1_21868756_ChIP-Seq_MCF10A_Human1.44016654
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.43008526
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39952945
57E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.38753531
58ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.38689075
59RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.38485429
60AR_21572438_ChIP-Seq_LNCaP_Human1.37940815
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34425448
62KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.33827223
63KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.33827223
64KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.33827223
65BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.33673115
66* SMAD4_21799915_ChIP-Seq_A2780_Human1.31907549
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.31544004
68STAT3_23295773_ChIP-Seq_U87_Human1.30980930
69RING1B_27294783_Chip-Seq_ESCs_Mouse1.30867863
70EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30413125
71TCF4_18268006_ChIP-ChIP_LS174T_Human1.30339260
72OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.30315656
73BCAT_22108803_ChIP-Seq_LS180_Human1.28458299
74SOX2_21211035_ChIP-Seq_LN229_Gbm1.25721848
75CBX2_27304074_Chip-Seq_ESCs_Mouse1.24887447
76DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22977685
77ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.22652878
78KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.22273413
79PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21043350
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18100540
81AR_19668381_ChIP-Seq_PC3_Human1.17896875
82ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.17082539
83* P300_19829295_ChIP-Seq_ESCs_Human1.16637965
84HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.16024847
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14218873
86ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13930357
87WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12755978
88AR_25329375_ChIP-Seq_VCAP_Human1.12573016
89RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12085882
90YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11572205
91GATA4_25053715_ChIP-Seq_YYC3_Human1.09867557
92LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08605214
93SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.07389755
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07267238
95OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06813487
96NANOG_16153702_ChIP-ChIP_HESCs_Human1.06614017
97CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.06407872
98P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06101211
99CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06048104
100RUNX2_22187159_ChIP-Seq_PCA_Human1.05871407
101KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05522842
102SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.05184974
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04938098
104VDR_22108803_ChIP-Seq_LS180_Human1.04562630
105CTCF_27219007_Chip-Seq_Bcells_Human1.04435442
106NANOG_19829295_ChIP-Seq_ESCs_Human1.03710508
107SOX2_19829295_ChIP-Seq_ESCs_Human1.03710508
108TAF15_26573619_Chip-Seq_HEK293_Human1.03527432
109SMAD3_21741376_ChIP-Seq_EPCs_Human1.01985687
110SMAD4_21741376_ChIP-Seq_HESCs_Human1.00145043
111E2F1_17053090_ChIP-ChIP_MCF-7_Human0.98949517
112TBX3_20139965_ChIP-Seq_MESCs_Mouse0.98927586
113SMAD3_21741376_ChIP-Seq_HESCs_Human0.98602505
114KAP1_22055183_ChIP-Seq_ESCs_Mouse0.98485050
115SALL4_18804426_ChIP-ChIP_XEN_Mouse0.97530687
116PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97178143
117ERG_21242973_ChIP-ChIP_JURKAT_Human0.96432102
118SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96113892
119SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95702836
120SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95351783
121UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95083956
122POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95043071
123POU3F2_20337985_ChIP-ChIP_501MEL_Human0.94777027
124SMAD3_21741376_ChIP-Seq_ESCs_Human0.94746814
125TBX3_20139965_ChIP-Seq_ESCs_Mouse0.94050004
126FUS_26573619_Chip-Seq_HEK293_Human0.93837122
127TP53_20018659_ChIP-ChIP_R1E_Mouse0.92721737
128RXR_22108803_ChIP-Seq_LS180_Human0.92568515
129ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92523007
130MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92021674
131FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92017677
132MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91614264
133RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91574165
134IGF1R_20145208_ChIP-Seq_DFB_Human0.91392529
135EOMES_21245162_ChIP-Seq_HESCs_Human0.91253872
136TCF4_22108803_ChIP-Seq_LS180_Human0.90908080
137ZFP57_27257070_Chip-Seq_ESCs_Mouse0.90858201
138RING1B_27294783_Chip-Seq_NPCs_Mouse0.90806357
139MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.90308202
140TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89983532
141* TCF4_23295773_ChIP-Seq_U87_Human0.89599905
142RNF2_27304074_Chip-Seq_NSC_Mouse0.88926762
143CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87894724
144* MYC_19829295_ChIP-Seq_ESCs_Human0.87824583
145TET1_21490601_ChIP-Seq_MESCs_Mouse0.87771913
146SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87234935
147TP53_16413492_ChIP-PET_HCT116_Human0.86499694
148TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.85531696
149ZNF263_19887448_ChIP-Seq_K562_Human0.85450259
150NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.84543331
151FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.81260857
152* PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.81210908
153NFE2_27457419_Chip-Seq_LIVER_Mouse0.80925782
154SMAD4_21741376_ChIP-Seq_EPCs_Human0.80582235
155TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.80499423
156CDX2_20551321_ChIP-Seq_CACO-2_Human0.80233897
157FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.79898880
158POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.78961159
159TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78961159
160CTNNB1_20460455_ChIP-Seq_HCT116_Human0.78724026
161TCF3_18692474_ChIP-Seq_MESCs_Mouse0.78278864
162AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.77552279
163MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.76834534
164HOXB7_26014856_ChIP-Seq_BT474_Human0.76202875
165NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.75625206

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color8.04684092
2MP0005171_absent_coat_pigmentation5.33800416
3MP0003195_calcinosis4.07826084
4MP0005360_urolithiasis3.75274801
5MP0003122_maternal_imprinting3.34219040
6MP0005365_abnormal_bile_salt3.07599920
7MP0004043_abnormal_pH_regulation3.03670843
8MP0002139_abnormal_hepatobiliary_system3.01004274
9MP0010329_abnormal_lipoprotein_level2.98602463
10MP0004858_abnormal_nervous_system2.91632914
11MP0003283_abnormal_digestive_organ2.76641906
12MP0001666_abnormal_nutrient_absorption2.56311297
13MP0005423_abnormal_somatic_nervous2.52229248
14MP0000566_synostosis2.34714500
15MP0005645_abnormal_hypothalamus_physiol2.33041055
16MP0002837_dystrophic_cardiac_calcinosis2.28426349
17MP0004270_analgesia2.25395944
18MP0004859_abnormal_synaptic_plasticity2.23871276
19MP0005646_abnormal_pituitary_gland2.23487230
20MP0009780_abnormal_chondrocyte_physiolo2.21867885
21MP0005085_abnormal_gallbladder_physiolo2.15214848
22MP0002909_abnormal_adrenal_gland2.06782925
23MP0003635_abnormal_synaptic_transmissio2.03568672
24MP0001529_abnormal_vocalization1.97256452
25MP0002938_white_spotting1.91451087
26MP0002653_abnormal_ependyma_morphology1.90103823
27MP0008875_abnormal_xenobiotic_pharmacok1.88762657
28MP0009046_muscle_twitch1.85078503
29MP0003890_abnormal_embryonic-extraembry1.78606320
30MP0009745_abnormal_behavioral_response1.71039787
31MP0002876_abnormal_thyroid_physiology1.68924022
32MP0003567_abnormal_fetal_cardiomyocyte1.67258327
33MP0003123_paternal_imprinting1.66885765
34MP0003880_abnormal_central_pattern1.64574884
35MP0003121_genomic_imprinting1.64202715
36MP0002572_abnormal_emotion/affect_behav1.61036867
37MP0001986_abnormal_taste_sensitivity1.59994210
38MP0003690_abnormal_glial_cell1.57714841
39MP0002064_seizures1.53619132
40MP0000013_abnormal_adipose_tissue1.52342510
41MP0003183_abnormal_peptide_metabolism1.51899379
42MP0002254_reproductive_system_inflammat1.49793521
43MP0002063_abnormal_learning/memory/cond1.46785482
44MP0001440_abnormal_grooming_behavior1.46096389
45MP0006072_abnormal_retinal_apoptosis1.45916053
46MP0004885_abnormal_endolymph1.44901964
47MP0004133_heterotaxia1.44874381
48MP0002693_abnormal_pancreas_physiology1.42135690
49MP0002877_abnormal_melanocyte_morpholog1.38102858
50MP0003787_abnormal_imprinting1.38044522
51MP0005408_hypopigmentation1.37979749
52MP0005174_abnormal_tail_pigmentation1.37801686
53MP0001270_distended_abdomen1.37675858
54MP0001293_anophthalmia1.36632325
55MP0005332_abnormal_amino_acid1.34698931
56MP0008877_abnormal_DNA_methylation1.34237790
57MP0005551_abnormal_eye_electrophysiolog1.33291559
58MP0002272_abnormal_nervous_system1.32881436
59MP0009840_abnormal_foam_cell1.32513603
60MP0004215_abnormal_myocardial_fiber1.32423056
61MP0003878_abnormal_ear_physiology1.31108935
62MP0005377_hearing/vestibular/ear_phenot1.31108935
63MP0003172_abnormal_lysosome_physiology1.30203393
64MP0005084_abnormal_gallbladder_morpholo1.29879010
65MP0001502_abnormal_circadian_rhythm1.27799641
66MP0001501_abnormal_sleep_pattern1.24662121
67MP0002734_abnormal_mechanical_nocicepti1.24133638
68MP0003942_abnormal_urinary_system1.22663470
69MP0001944_abnormal_pancreas_morphology1.22608461
70MP0003011_delayed_dark_adaptation1.22039605
71MP0002638_abnormal_pupillary_reflex1.21706428
72MP0001486_abnormal_startle_reflex1.20859030
73MP0001970_abnormal_pain_threshold1.20381922
74MP0002118_abnormal_lipid_homeostasis1.19840687
75MP0001968_abnormal_touch/_nociception1.19424422
76MP0003329_amyloid_beta_deposits1.16168825
77MP0002733_abnormal_thermal_nociception1.15881439
78MP0004142_abnormal_muscle_tone1.15445025
79MP0006276_abnormal_autonomic_nervous1.15270699
80MP0003646_muscle_fatigue1.14627216
81MP0005379_endocrine/exocrine_gland_phen1.14364507
82MP0003137_abnormal_impulse_conducting1.12664083
83MP0003868_abnormal_feces_composition1.12519757
84MP0000639_abnormal_adrenal_gland1.12320341
85MP0005167_abnormal_blood-brain_barrier1.11089709
86MP0006292_abnormal_olfactory_placode1.10916754
87MP0003252_abnormal_bile_duct1.10084270
88MP0002751_abnormal_autonomic_nervous1.09898236
89MP0003633_abnormal_nervous_system1.09052477
90MP0002078_abnormal_glucose_homeostasis1.09006495
91MP0003879_abnormal_hair_cell1.08759781
92MP0002163_abnormal_gland_morphology1.08516728
93MP0001905_abnormal_dopamine_level1.05285081
94MP0004233_abnormal_muscle_weight1.04980505
95MP0002067_abnormal_sensory_capabilities1.04838791
96MP0004924_abnormal_behavior1.03854849
97MP0005386_behavior/neurological_phenoty1.03854849
98MP0002160_abnormal_reproductive_system1.03512174
99MP0006054_spinal_hemorrhage1.03406345
100MP0004085_abnormal_heartbeat1.01098533
101MP0003634_abnormal_glial_cell1.00739608
102MP0002557_abnormal_social/conspecific_i1.00679323
103MP0000751_myopathy1.00557153
104MP0010386_abnormal_urinary_bladder0.99892959
105MP0010368_abnormal_lymphatic_system0.99539338
106MP0002233_abnormal_nose_morphology0.97657553
107MP0001664_abnormal_digestion0.97606456
108MP0001915_intracranial_hemorrhage0.96702858
109MP0004019_abnormal_vitamin_homeostasis0.95995629
110MP0008569_lethality_at_weaning0.95449530
111MP0005636_abnormal_mineral_homeostasis0.95389078
112MP0003941_abnormal_skin_development0.95344829
113MP0005253_abnormal_eye_physiology0.95295467
114MP0003937_abnormal_limbs/digits/tail_de0.95175185
115MP0001286_abnormal_eye_development0.95021414
116MP0002089_abnormal_postnatal_growth/wei0.94522073
117MP0002736_abnormal_nociception_after0.93031633
118MP0000631_abnormal_neuroendocrine_gland0.92078156
119MP0004264_abnormal_extraembryonic_tissu0.91792733
120MP0005220_abnormal_exocrine_pancreas0.89238453
121MP0003119_abnormal_digestive_system0.88222659
122MP0003631_nervous_system_phenotype0.87186686
123MP0003075_altered_response_to0.87151168
124MP0001324_abnormal_eye_pigmentation0.85192385
125MP0005535_abnormal_body_temperature0.83924352
126MP0000609_abnormal_liver_physiology0.83802058
127MP0000462_abnormal_digestive_system0.82382504
128MP0000678_abnormal_parathyroid_gland0.81608531
129MP0003718_maternal_effect0.81486396
130MP0002229_neurodegeneration0.81074223
131MP0002090_abnormal_vision0.79792091
132MP0003115_abnormal_respiratory_system0.79715825
133MP0009384_cardiac_valve_regurgitation0.79137604
134MP0002972_abnormal_cardiac_muscle0.78623590
135MP0000230_abnormal_systemic_arterial0.78203683
136MP0000955_abnormal_spinal_cord0.77981637
137MP0003938_abnormal_ear_development0.77977126
138MP0003953_abnormal_hormone_level0.77872384
139MP0002822_catalepsy0.77571230
140MP0004145_abnormal_muscle_electrophysio0.74743587
141MP0001963_abnormal_hearing_physiology0.74408770
142MP0005410_abnormal_fertilization0.73052631
143MP0008961_abnormal_basal_metabolism0.72661158
144MP0005330_cardiomyopathy0.72359687
145MP0001756_abnormal_urination0.72030324
146MP0002132_abnormal_respiratory_system0.71534827
147MP0003315_abnormal_perineum_morphology0.71173626
148MP0002066_abnormal_motor_capabilities/c0.70556769
149MP0001485_abnormal_pinna_reflex0.70476823
150MP0002127_abnormal_cardiovascular_syste0.70411543
151MP0005391_vision/eye_phenotype0.70227376
152MP0003632_abnormal_nervous_system0.68631086
153MP0002092_abnormal_eye_morphology0.68377804
154MP0002882_abnormal_neuron_morphology0.68263109
155MP0002184_abnormal_innervation0.68162565
156MP0002697_abnormal_eye_size0.67682538
157MP0004036_abnormal_muscle_relaxation0.67398170
158MP0000750_abnormal_muscle_regeneration0.67206787
159MP0001984_abnormal_olfaction0.66900996
160MP0000003_abnormal_adipose_tissue0.66661733
161MP0005195_abnormal_posterior_eye0.65558558
162MP0001764_abnormal_homeostasis0.61916043
163MP0003698_abnormal_male_reproductive0.60921518
164MP0003943_abnormal_hepatobiliary_system0.58944826
165MP0001299_abnormal_eye_distance/0.58230596

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.99562390
2Large for gestational age (HP:0001520)7.49528557
3Prolonged partial thromboplastin time (HP:0003645)6.35300275
4Hyperinsulinemic hypoglycemia (HP:0000825)6.30218677
5Hypobetalipoproteinemia (HP:0003563)5.48512672
6Joint hemorrhage (HP:0005261)4.72734502
7Hypoglycemic seizures (HP:0002173)4.68897331
8Hypothermia (HP:0002045)4.45265718
9Abnormal auditory evoked potentials (HP:0006958)4.39708128
10Hypoglycemic coma (HP:0001325)4.32884812
11Blue irides (HP:0000635)4.19774917
12Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.19147159
13Abnormality of the common coagulation pathway (HP:0010990)4.14206800
14Hepatoblastoma (HP:0002884)4.13037209
15Broad alveolar ridges (HP:0000187)4.00337462
16Ketoacidosis (HP:0001993)3.84717726
17White forelock (HP:0002211)3.81203844
18Symptomatic seizures (HP:0011145)3.80741811
19Spontaneous abortion (HP:0005268)3.76042839
20Hypolipoproteinemia (HP:0010981)3.64098596
21Hemiparesis (HP:0001269)3.60487632
22Spastic paraparesis (HP:0002313)3.45080614
23Xanthomatosis (HP:0000991)3.43516738
24Patchy hypopigmentation of hair (HP:0011365)3.41703951
25Hypercholesterolemia (HP:0003124)3.40109188
26Abnormality of the nasal septum (HP:0000419)3.27473522
27Epidermoid cyst (HP:0200040)3.23367789
28Pheochromocytoma (HP:0002666)3.20312597
29Albinism (HP:0001022)3.20165272
30Increased serum pyruvate (HP:0003542)3.19872019
31Hypopigmentation of the fundus (HP:0007894)3.16610966
32Complement deficiency (HP:0004431)3.15181203
33Acanthocytosis (HP:0001927)3.12379170
34Osteomalacia (HP:0002749)3.09299239
35Aplasia/Hypoplasia of the fovea (HP:0008060)3.09093576
36Hypoplasia of the fovea (HP:0007750)3.09093576
37Paraparesis (HP:0002385)3.05460421
38Hyperglycinemia (HP:0002154)3.02931649
39Abnormality of aromatic amino acid family metabolism (HP:0004338)3.00961041
40Hemiplegia (HP:0002301)2.96672862
41Visual hallucinations (HP:0002367)2.95650896
42Abnormality of calcium-phosphate metabolism (HP:0100530)2.92219474
43Neuroendocrine neoplasm (HP:0100634)2.91857350
44Hyperglycemia (HP:0003074)2.88384692
45Abnormality of glycolysis (HP:0004366)2.87067815
46Aplasia involving bones of the extremities (HP:0009825)2.85481607
47Aplasia involving bones of the upper limbs (HP:0009823)2.85481607
48Aplasia of the phalanges of the hand (HP:0009802)2.85481607
49Enlarged kidneys (HP:0000105)2.84574683
50Small epiphyses (HP:0010585)2.83017668
51Vaginal fistula (HP:0004320)2.79013315
52Abnormality of binocular vision (HP:0011514)2.78340332
53Diplopia (HP:0000651)2.78340332
54Abnormal autonomic nervous system physiology (HP:0012332)2.75060412
55Insulin-resistant diabetes mellitus (HP:0000831)2.74934085
56Bifid tongue (HP:0010297)2.73049547
57Glomerulonephritis (HP:0000099)2.70660036
58Abnormality of the fovea (HP:0000493)2.70450484
59Supernumerary spleens (HP:0009799)2.65118722
60Heterochromia iridis (HP:0001100)2.65021915
61Diastasis recti (HP:0001540)2.64589692
62Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.63710727
63Broad palm (HP:0001169)2.62968003
64Generalized tonic-clonic seizures (HP:0002069)2.62199958
65Abnormal tarsal ossification (HP:0008369)2.61734317
66Abnormality of glycine metabolism (HP:0010895)2.61031595
67Abnormality of serine family amino acid metabolism (HP:0010894)2.61031595
68Hyperglycinuria (HP:0003108)2.57744308
69Thyroid-stimulating hormone excess (HP:0002925)2.53209697
70Maternal diabetes (HP:0009800)2.53131801
71Bilateral microphthalmos (HP:0007633)2.52094571
72Menorrhagia (HP:0000132)2.49135153
73Vascular calcification (HP:0004934)2.46210111
74Hypophosphatemic rickets (HP:0004912)2.41383969
75Failure to thrive in infancy (HP:0001531)2.38217065
76Agitation (HP:0000713)2.36507998
77Atonic seizures (HP:0010819)2.35160742
78Short middle phalanx of the 5th finger (HP:0004220)2.34394043
79Epiphyseal dysplasia (HP:0002656)2.33872657
80Hypoalphalipoproteinemia (HP:0003233)2.33088928
81Neoplasm of the thyroid gland (HP:0100031)2.32745439
82Late onset (HP:0003584)2.31318180
83Epileptic encephalopathy (HP:0200134)2.29537625
84Focal motor seizures (HP:0011153)2.29395099
85Pancreatic islet-cell hyperplasia (HP:0004510)2.29186316
86Abnormality of endocrine pancreas physiology (HP:0012093)2.28838569
87Abnormality of the pancreatic islet cells (HP:0006476)2.28838569
88Nephroblastoma (Wilms tumor) (HP:0002667)2.28435787
89Decreased circulating renin level (HP:0003351)2.24454533
90Absent eyebrow (HP:0002223)2.24191987
91Abnormality of carpal bone ossification (HP:0006257)2.22121469
92Irregular epiphyses (HP:0010582)2.19340431
93Intrahepatic cholestasis (HP:0001406)2.18454516
94Generalized hypopigmentation (HP:0007513)2.18385440
95Depression (HP:0000716)2.16722533
96Facial shape deformation (HP:0011334)2.16630310
97Potter facies (HP:0002009)2.16630310
98Generalized aminoaciduria (HP:0002909)2.14579681
99Embryonal renal neoplasm (HP:0011794)2.14391521
100Megalencephaly (HP:0001355)2.11900889
101Tetraplegia (HP:0002445)2.11702976
102Abnormal pancreas size (HP:0012094)2.07984545
103Intestinal polyposis (HP:0200008)2.06821353
104Ketosis (HP:0001946)2.06789579
105Increased circulating renin level (HP:0000848)2.04677301
106Impaired pain sensation (HP:0007328)2.02683702
107Abnormality of pain sensation (HP:0010832)2.02683702
108Hemorrhage of the eye (HP:0011885)2.02586336
109Abnormality of the vitreous humor (HP:0004327)2.01027929
110Cardiovascular calcification (HP:0011915)2.00526161
111Anxiety (HP:0000739)1.99949452
112Menstrual irregularities (HP:0000858)1.99866878
113Rectal fistula (HP:0100590)1.98077779
114Rectovaginal fistula (HP:0000143)1.98077779
115Abnormality of the wing of the ilium (HP:0011867)1.97768933
116Truncal ataxia (HP:0002078)1.97474240
117Left ventricular hypertrophy (HP:0001712)1.97194552
118Hypoplasia of the capital femoral epiphysis (HP:0003090)1.96277941
119Widely patent fontanelles and sutures (HP:0004492)1.94198696
120Gout (HP:0001997)1.93579852
121Myoglobinuria (HP:0002913)1.93525075
122Pigmentary retinal degeneration (HP:0001146)1.93348321
123Postural instability (HP:0002172)1.92994998
124Absence seizures (HP:0002121)1.91860019
125Hypokalemia (HP:0002900)1.90864631
126Exercise-induced myalgia (HP:0003738)1.89945928
127Scrotal hypoplasia (HP:0000046)1.89082061
128EEG with generalized epileptiform discharges (HP:0011198)1.88809729
129Focal seizures (HP:0007359)1.87751048
130Asymmetry of the thorax (HP:0001555)1.87668254
131Abnormality of the alveolar ridges (HP:0006477)1.87556883
132Neoplasm of the liver (HP:0002896)1.87241145
133Hypsarrhythmia (HP:0002521)1.87172107
134Absent epiphyses (HP:0010577)1.87163014
135Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.87163014
136Anophthalmia (HP:0000528)1.85888505
137Intestinal polyp (HP:0005266)1.85197701
138Retinal atrophy (HP:0001105)1.85041681
139Prolonged QT interval (HP:0001657)1.84642192
140Proximal tubulopathy (HP:0000114)1.84288515
141Epileptiform EEG discharges (HP:0011182)1.84193148
142Abnormality of the labia minora (HP:0012880)1.83133475
143Neurofibrillary tangles (HP:0002185)1.82607871
144Alacrima (HP:0000522)1.82454397
145Polyphagia (HP:0002591)1.82339909
146Hyperparathyroidism (HP:0000843)1.80571234
147Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.79907652
148Striae distensae (HP:0001065)1.79808972
149Absent eyelashes (HP:0000561)1.79206780
150Absent hair (HP:0002298)1.78842106
151Prenatal maternal abnormality (HP:0002686)1.78433839
152Narrow nasal bridge (HP:0000446)1.77910961
153Atrial fibrillation (HP:0005110)1.77202426
154Abnormal EKG (HP:0003115)1.76428438
155Neoplasm of the heart (HP:0100544)1.75599567
156Dialeptic seizures (HP:0011146)1.74139682
157Arthropathy (HP:0003040)1.74115388
158Hypoplastic left heart (HP:0004383)1.73893916
159Embryonal neoplasm (HP:0002898)1.73745310
160Wide nose (HP:0000445)1.73739419
161Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.73715683
162Fat malabsorption (HP:0002630)1.73657624
163Status epilepticus (HP:0002133)1.73523213
164Adducted thumb (HP:0001181)1.72908380
165Abnormality of renin-angiotensin system (HP:0000847)1.72780163
166Aplasia/Hypoplasia of the macula (HP:0008059)1.72344626
167Postural tremor (HP:0002174)1.72272602
168Poor suck (HP:0002033)1.72261132
169Supranuclear gaze palsy (HP:0000605)1.72124608
170Atrioventricular block (HP:0001678)1.70669002
171Decreased muscle mass (HP:0003199)1.70122789
172Meckel diverticulum (HP:0002245)1.69428920
173Abnormality of the ileum (HP:0001549)1.67991490
174Abnormality of the pubic bones (HP:0003172)1.66323521
175Abnormality of complement system (HP:0005339)1.66026527
176Myelomeningocele (HP:0002475)1.60806875
177Intestinal fistula (HP:0100819)1.59315426
178Gingival bleeding (HP:0000225)1.59168954
179Abnormality of the intrinsic pathway (HP:0010989)1.58961256
180Hypomagnesemia (HP:0002917)1.58616118
181Renal duplication (HP:0000075)1.57506081
182Malignant hyperthermia (HP:0002047)1.56886036
183Hepatocellular carcinoma (HP:0001402)1.55880846
184Gonadal dysgenesis (HP:0000133)1.54912915
185Bronchomalacia (HP:0002780)1.54627568

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRKD35.72383731
2FGFR44.76024417
3NTRK34.42065608
4INSRR3.83448703
5FGFR33.50184609
6FGFR23.29125554
7AKT33.00590400
8TNIK2.77793453
9LMTK22.73231925
10PASK2.68059817
11MAPK152.61189132
12NTRK22.43040124
13MAP2K72.33950671
14PHKG12.28177354
15PHKG22.28177354
16MAP3K42.18064572
17TYRO32.14723544
18BMPR1B2.08207759
19FGFR11.98249258
20PIK3CA1.94309798
21FRK1.79152209
22GRK51.77353000
23HIPK21.72096181
24MAPK131.71986133
25SGK21.67174540
26STK161.63823785
27NTRK11.61072919
28ARAF1.59247873
29BRAF1.58691507
30BCR1.56625892
31ERN11.54642863
32MARK11.54555126
33LATS11.48152386
34PAK31.47753948
35MAP4K21.46833285
36ALK1.42444931
37MAP2K41.40689407
38PRKCH1.39600865
39SGK2231.38717719
40SGK4941.38717719
41CDK81.34036732
42ICK1.32601869
43WNK41.31485711
44PRKD21.31312018
45NUAK11.30872727
46DYRK21.30309707
47GRK71.28350058
48PINK11.28163201
49ZAK1.27310410
50MAP3K91.26897861
51SIK21.22654377
52UHMK11.21287563
53CDC42BPA1.20536796
54PLK31.20174461
55TRIM281.18594589
56SGK31.17428938
57DYRK1B1.16102623
58PRKCG1.13603529
59DAPK21.11153697
60PRKCE1.09829551
61MINK11.05430806
62MAP3K21.04242004
63WNK11.03322732
64MUSK1.01515171
65CSNK1G10.97083442
66ADRBK20.93470461
67MAPK70.92910670
68CSNK1E0.92396100
69ERBB20.90462244
70STK390.89356702
71CSNK1A1L0.88705116
72DYRK30.86838388
73MKNK20.85841450
74EIF2AK30.82627912
75MAPK120.78588054
76CSNK1D0.78299536
77CDK50.77348193
78GRK10.76748046
79ADRBK10.75173403
80SGK10.73712166
81MAP3K70.72456714
82MAP3K10.71766554
83NEK10.71515604
84CAMK2D0.69027560
85MAP3K60.68992733
86CAMK2A0.68892865
87CSNK1G30.68433795
88SRPK10.68136203
89STK38L0.67993741
90CASK0.65627511
91MAP3K50.64585572
92RIPK10.64320949
93PRKCZ0.63553002
94EIF2AK10.63332056
95PAK60.63270572
96SCYL20.61527456
97CSNK1G20.61479429
98CAMK2G0.61129732
99TSSK60.60472441
100PLK20.59552812
101PLK40.59395159
102MKNK10.58336511
103NME10.58267358
104PDGFRA0.57719061
105ATM0.57525238
106PRKACG0.56400968
107MELK0.56239890
108PRPF4B0.55955036
109PRKD10.54220829
110RET0.53800546
111CDK70.53787518
112BCKDK0.52896281
113NEK60.52834230
114CDK120.51090914
115PRKACA0.50791954
116BRSK10.48100773
117CAMK2B0.46658559
118WNK30.46378465
119MET0.46056714
120ATR0.45653831
121IRAK20.45551824
122IGF1R0.45429464
123PLK10.42289915
124MARK20.41638539
125MAPK100.40907199
126TTK0.40445161
127RPS6KA30.39847874
128CSNK2A10.39324624
129CSNK2A20.38839949
130PRKCA0.38701498
131PDK20.38605200
132STK380.38143976
133PRKAA10.38029046
134PBK0.37697809
135KSR20.37686589
136VRK10.37020383
137TNK20.35890249
138DYRK1A0.33973344
139OBSCN0.31979425
140PRKCI0.30781859
141LATS20.29281450
142PKN10.28244657
143PRKG10.28187334
144RPS6KB10.27238323
145PRKDC0.26320622
146EPHA40.25522196
147NLK0.25130827
148PRKAA20.25059992
149SIK10.24962020
150CAMKK10.24897286
151CSNK1A10.24657141
152FER0.24352211
153PRKACB0.24315047
154RPS6KA20.24056736
155PRKCB0.23971341
156GRK60.23435108

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.44112810
2Complement and coagulation cascades_Homo sapiens_hsa046103.64608923
3Steroid biosynthesis_Homo sapiens_hsa001003.56556390
4Insulin secretion_Homo sapiens_hsa049112.98960485
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.80395126
6Fat digestion and absorption_Homo sapiens_hsa049752.75994223
7GABAergic synapse_Homo sapiens_hsa047272.71283130
8Nicotine addiction_Homo sapiens_hsa050332.58074545
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.44890178
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.38511108
11Nitrogen metabolism_Homo sapiens_hsa009102.37065682
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.29126504
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.28826346
14Sulfur metabolism_Homo sapiens_hsa009202.25598316
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.19552492
16Vitamin digestion and absorption_Homo sapiens_hsa049772.13779930
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.11996700
18Protein export_Homo sapiens_hsa030602.10580862
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.04579363
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.95641507
21Vitamin B6 metabolism_Homo sapiens_hsa007501.91126209
22Taste transduction_Homo sapiens_hsa047421.86778140
23Histidine metabolism_Homo sapiens_hsa003401.83639941
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.80808313
25Circadian entrainment_Homo sapiens_hsa047131.79546515
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.74904391
27Type II diabetes mellitus_Homo sapiens_hsa049301.73860778
28Cocaine addiction_Homo sapiens_hsa050301.71926777
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.67856748
30Fatty acid biosynthesis_Homo sapiens_hsa000611.67728577
31PPAR signaling pathway_Homo sapiens_hsa033201.66860995
32Morphine addiction_Homo sapiens_hsa050321.64040037
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.62170113
34Carbohydrate digestion and absorption_Homo sapiens_hsa049731.61239721
35Synaptic vesicle cycle_Homo sapiens_hsa047211.60988569
36Vibrio cholerae infection_Homo sapiens_hsa051101.58780431
37Long-term potentiation_Homo sapiens_hsa047201.58738681
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.58343401
39Glutamatergic synapse_Homo sapiens_hsa047241.57203975
40Arginine and proline metabolism_Homo sapiens_hsa003301.54252116
41Arginine biosynthesis_Homo sapiens_hsa002201.50540431
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.49828583
43Cardiac muscle contraction_Homo sapiens_hsa042601.49166059
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.47902016
45Amphetamine addiction_Homo sapiens_hsa050311.47865019
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.47390024
47Renin secretion_Homo sapiens_hsa049241.36958674
48Salivary secretion_Homo sapiens_hsa049701.35375139
49Peroxisome_Homo sapiens_hsa041461.35336096
50Butanoate metabolism_Homo sapiens_hsa006501.33874742
51Pyruvate metabolism_Homo sapiens_hsa006201.33558406
52Serotonergic synapse_Homo sapiens_hsa047261.32289221
53Gastric acid secretion_Homo sapiens_hsa049711.31964854
54Bile secretion_Homo sapiens_hsa049761.25715723
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22474481
56Calcium signaling pathway_Homo sapiens_hsa040201.22462609
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.21040441
58Type I diabetes mellitus_Homo sapiens_hsa049401.20086649
59Dopaminergic synapse_Homo sapiens_hsa047281.19326314
60Pancreatic secretion_Homo sapiens_hsa049721.18160523
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.15780798
62Thyroid hormone synthesis_Homo sapiens_hsa049181.14086090
63beta-Alanine metabolism_Homo sapiens_hsa004101.13661070
64Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.12533167
65Melanogenesis_Homo sapiens_hsa049161.10086068
66Oxidative phosphorylation_Homo sapiens_hsa001901.03273058
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.02880740
68ABC transporters_Homo sapiens_hsa020101.01060411
69cAMP signaling pathway_Homo sapiens_hsa040241.00124714
70Dilated cardiomyopathy_Homo sapiens_hsa054140.99970138
71Olfactory transduction_Homo sapiens_hsa047400.99755448
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.99664670
73Long-term depression_Homo sapiens_hsa047300.99059071
74Collecting duct acid secretion_Homo sapiens_hsa049660.98433373
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96552128
76Biosynthesis of amino acids_Homo sapiens_hsa012300.96334011
77Lysine degradation_Homo sapiens_hsa003100.95625211
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92428438
79Chemical carcinogenesis_Homo sapiens_hsa052040.89671969
80Cholinergic synapse_Homo sapiens_hsa047250.89654384
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88338128
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.88323475
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86866645
84Gap junction_Homo sapiens_hsa045400.86642373
85Alzheimers disease_Homo sapiens_hsa050100.86456818
86Parkinsons disease_Homo sapiens_hsa050120.85560567
87Retinol metabolism_Homo sapiens_hsa008300.85500244
88Glucagon signaling pathway_Homo sapiens_hsa049220.85260135
89Prion diseases_Homo sapiens_hsa050200.83973409
90Glycerolipid metabolism_Homo sapiens_hsa005610.81978470
91One carbon pool by folate_Homo sapiens_hsa006700.81851647
92Carbon metabolism_Homo sapiens_hsa012000.80597436
93Galactose metabolism_Homo sapiens_hsa000520.80056688
94Dorso-ventral axis formation_Homo sapiens_hsa043200.78797786
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78491089
96Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.78396676
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75808113
98Tyrosine metabolism_Homo sapiens_hsa003500.74661918
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74459566
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.73992670
101Cysteine and methionine metabolism_Homo sapiens_hsa002700.72416724
102Fatty acid metabolism_Homo sapiens_hsa012120.71692738
103Glycosaminoglycan degradation_Homo sapiens_hsa005310.71028362
104Estrogen signaling pathway_Homo sapiens_hsa049150.70737172
105Fatty acid degradation_Homo sapiens_hsa000710.70187828
106Circadian rhythm_Homo sapiens_hsa047100.68436056
107Metabolic pathways_Homo sapiens_hsa011000.65959928
108GnRH signaling pathway_Homo sapiens_hsa049120.65113050
109Cyanoamino acid metabolism_Homo sapiens_hsa004600.63957865
110Huntingtons disease_Homo sapiens_hsa050160.62310833
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61806228
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59923782
113Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59701264
114N-Glycan biosynthesis_Homo sapiens_hsa005100.59526007
115Lysosome_Homo sapiens_hsa041420.58580625
116Tryptophan metabolism_Homo sapiens_hsa003800.58198445
117Insulin signaling pathway_Homo sapiens_hsa049100.57354767
118Glutathione metabolism_Homo sapiens_hsa004800.55999730
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54708551
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.54164120
121Other glycan degradation_Homo sapiens_hsa005110.53988994
122Fructose and mannose metabolism_Homo sapiens_hsa000510.53108485
123Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52608592
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51610423
125Insulin resistance_Homo sapiens_hsa049310.51331852
126Sphingolipid metabolism_Homo sapiens_hsa006000.51018021
127RNA polymerase_Homo sapiens_hsa030200.49087085
128alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48454454
129Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48433658
130Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48103021
131Phototransduction_Homo sapiens_hsa047440.48020892
132Oxytocin signaling pathway_Homo sapiens_hsa049210.47061941
1332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46890668
134Starch and sucrose metabolism_Homo sapiens_hsa005000.45916603
135Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44349700
136Phospholipase D signaling pathway_Homo sapiens_hsa040720.43905878
137Ovarian steroidogenesis_Homo sapiens_hsa049130.43218905
138Thyroid cancer_Homo sapiens_hsa052160.41895503
139Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41398966
140Glycerophospholipid metabolism_Homo sapiens_hsa005640.41077262
141mRNA surveillance pathway_Homo sapiens_hsa030150.39540478
142Phenylalanine metabolism_Homo sapiens_hsa003600.39477186
143Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38654690
144Inositol phosphate metabolism_Homo sapiens_hsa005620.38274632
145Mineral absorption_Homo sapiens_hsa049780.38062281
146Hedgehog signaling pathway_Homo sapiens_hsa043400.37705078
147Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36548631
148Ether lipid metabolism_Homo sapiens_hsa005650.35675601
149Adipocytokine signaling pathway_Homo sapiens_hsa049200.34716366
150Renin-angiotensin system_Homo sapiens_hsa046140.33971319
151Fatty acid elongation_Homo sapiens_hsa000620.32971217
152Selenocompound metabolism_Homo sapiens_hsa004500.32653132
153Propanoate metabolism_Homo sapiens_hsa006400.31955249
154Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31403852
155RNA degradation_Homo sapiens_hsa030180.30832299
156RNA transport_Homo sapiens_hsa030130.29278010
157Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.28443586
158Non-homologous end-joining_Homo sapiens_hsa034500.28384435
159Axon guidance_Homo sapiens_hsa043600.25423453
160Hippo signaling pathway_Homo sapiens_hsa043900.22659062
161Wnt signaling pathway_Homo sapiens_hsa043100.22381116

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