IGLV8-61

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of respiratory burst (GO:0060267)9.69536543
2complement activation (GO:0006956)9.02422515
3glomerular filtration (GO:0003094)7.86535748
4renal filtration (GO:0097205)7.10144465
5protein activation cascade (GO:0072376)6.63906890
6regulation of respiratory burst (GO:0060263)6.30726208
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.19541246
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.17591791
9antigen processing and presentation of endogenous antigen (GO:0019883)5.84856229
10antimicrobial humoral response (GO:0019730)5.40793530
11antibacterial humoral response (GO:0019731)5.39313404
12Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)5.38157667
13immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00025.38157667
14Fc-gamma receptor signaling pathway (GO:0038094)5.38157667
15Fc receptor mediated stimulatory signaling pathway (GO:0002431)5.35681743
16humoral immune response (GO:0006959)5.21238361
17regulation of cellular extravasation (GO:0002691)4.56125353
18retina homeostasis (GO:0001895)4.43566615
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.26725541
20germinal center formation (GO:0002467)4.09359295
21regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.08878991
22detection of bacterium (GO:0016045)3.97115563
23regulation of dendritic cell antigen processing and presentation (GO:0002604)3.93953728
24immunoglobulin mediated immune response (GO:0016064)3.91548569
25interferon-gamma-mediated signaling pathway (GO:0060333)3.90304230
26detection of other organism (GO:0098543)3.89533375
27regulation of antigen processing and presentation (GO:0002577)3.88710517
28negative regulation of cell killing (GO:0031342)3.84637975
29negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.84637975
30type I interferon signaling pathway (GO:0060337)3.80474021
31cellular response to type I interferon (GO:0071357)3.80474021
32response to type I interferon (GO:0034340)3.80130293
33positive regulation of antigen processing and presentation (GO:0002579)3.70770441
34chronic inflammatory response (GO:0002544)3.60775528
35immune response-activating cell surface receptor signaling pathway (GO:0002429)3.40847480
36positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.38982780
37positive regulation of pseudopodium assembly (GO:0031274)3.38852859
38regulation of integrin activation (GO:0033623)3.36728326
39angiotensin maturation (GO:0002003)3.23614576
40cellular response to interferon-gamma (GO:0071346)3.14831840
41protein-chromophore linkage (GO:0018298)3.11823699
42regulation of T cell tolerance induction (GO:0002664)3.09170870
43response to interferon-gamma (GO:0034341)3.06663456
44NIK/NF-kappaB signaling (GO:0038061)3.03582196
45positive regulation of gamma-delta T cell activation (GO:0046645)3.01786185
46regulation of pseudopodium assembly (GO:0031272)3.01779221
47positive regulation of Cdc42 GTPase activity (GO:0043089)3.01714895
48myeloid dendritic cell differentiation (GO:0043011)2.97493786
49detection of external biotic stimulus (GO:0098581)2.93454304
50B cell mediated immunity (GO:0019724)2.87225254
51regulation of regulatory T cell differentiation (GO:0045589)2.84320236
52regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.82353678
53myeloid dendritic cell activation (GO:0001773)2.79450461
54positive regulation of T cell migration (GO:2000406)2.79374183
55negative regulation of myotube differentiation (GO:0010832)2.79184093
56regulation of tolerance induction (GO:0002643)2.78481079
57virion attachment to host cell (GO:0019062)2.73214892
58adhesion of symbiont to host cell (GO:0044650)2.73214892
59regulation of type I interferon-mediated signaling pathway (GO:0060338)2.71168445
60regulation of glucose import in response to insulin stimulus (GO:2001273)2.70673180
61T-helper 1 type immune response (GO:0042088)2.70317354
62response to interferon-beta (GO:0035456)2.68567754
63endothelial cell chemotaxis (GO:0035767)2.68522393
64dendritic cell chemotaxis (GO:0002407)2.66675366
65regulation of T cell migration (GO:2000404)2.66578668
66immune response-activating signal transduction (GO:0002757)2.64107328
67activation of immune response (GO:0002253)2.63218267
68interferon-gamma secretion (GO:0072643)2.60205594
69eosinophil chemotaxis (GO:0048245)2.55986000
70peptide catabolic process (GO:0043171)2.53818255
71lymphocyte chemotaxis (GO:0048247)2.53669927
72positive regulation of tolerance induction (GO:0002645)2.53401747
73antigen processing and presentation via MHC class Ib (GO:0002475)2.53132186
74detection of biotic stimulus (GO:0009595)2.49717222
75production of molecular mediator of immune response (GO:0002440)2.47561394
76regulation of necrotic cell death (GO:0010939)2.47462896
77positive regulation of lymphocyte migration (GO:2000403)2.47085676
78maintenance of gastrointestinal epithelium (GO:0030277)2.45797451
79regulation of endothelial cell chemotaxis (GO:2001026)2.43019709
80lymph node development (GO:0048535)2.39637680
81T cell costimulation (GO:0031295)2.38178699
82defense response to Gram-negative bacterium (GO:0050829)2.35734561
83lymphocyte costimulation (GO:0031294)2.34450950
84negative regulation of innate immune response (GO:0045824)2.32609889
85eosinophil migration (GO:0072677)2.31795897
86regulation of macrophage chemotaxis (GO:0010758)2.30178621
87surfactant homeostasis (GO:0043129)2.28648778
88positive regulation of Rap GTPase activity (GO:0032854)2.27310226
89low-density lipoprotein particle remodeling (GO:0034374)2.27244758
90adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.26212645
91regulation of gamma-delta T cell activation (GO:0046643)2.25226762
92positive thymic T cell selection (GO:0045059)2.25060593
93production of molecular mediator involved in inflammatory response (GO:0002532)2.24960664
94negative regulation of leukocyte mediated immunity (GO:0002704)2.23286861
95dendritic cell differentiation (GO:0097028)2.22482181
96dendritic cell migration (GO:0036336)2.22320026
97respiratory burst (GO:0045730)2.21809700
98adhesion of symbiont to host (GO:0044406)2.21474772
99regulation of lymphocyte migration (GO:2000401)2.21436215
100complement activation, classical pathway (GO:0006958)11.3419375

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.00420190
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.16028611
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.02043547
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.50333994
5RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.15362313
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.10056087
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.99453671
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.33000328
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.28105727
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12159941
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.04720598
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.04352169
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.03872528
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.96530378
15TRIM28_21343339_ChIP-Seq_HEK293_Human1.88190732
16LXR_22292898_ChIP-Seq_THP-1_Human1.87776725
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.86293516
18CDX2_20551321_ChIP-Seq_CACO-2_Human1.83674364
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.83095109
20STAT4_19710469_ChIP-ChIP_TH1__Mouse1.78208142
21VDR_24763502_ChIP-Seq_THP-1_Human1.73292861
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.72688453
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.71308461
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.70252877
25E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.65099473
26VDR_21846776_ChIP-Seq_THP-1_Human1.64197464
27BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.63198678
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.62462470
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.59861779
30SOX2_27498859_Chip-Seq_STOMACH_Mouse1.59209815
31TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.57115711
32PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.53361463
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.52238142
34RUNX_20019798_ChIP-Seq_JUKART_Human1.49825032
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.46563224
36ELK3_25401928_ChIP-Seq_HUVEC_Human1.42770568
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.36717654
38CLOCK_20551151_ChIP-Seq_293T_Human1.36515622
39ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.35076374
40MAF_26560356_Chip-Seq_TH1_Human1.31703083
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.30529122
42SOX2_20726797_ChIP-Seq_SW620_Human1.30420910
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28651791
44SPI1_23127762_ChIP-Seq_K562_Human1.27886550
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.27601900
46RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.27401624
47MYB_26560356_Chip-Seq_TH2_Human1.25539431
48CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23926420
49BRD4_27068464_Chip-Seq_AML-cells_Mouse1.23653518
50EGR1_19032775_ChIP-ChIP_M12_Human1.21199585
51FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.20860906
52TCF7_22412390_ChIP-Seq_EML_Mouse1.19666142
53RXR_22158963_ChIP-Seq_LIVER_Mouse1.18951503
54UTX_26944678_Chip-Seq_JUKART_Human1.18825780
55CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18721935
56SPI1_23547873_ChIP-Seq_NB4_Human1.18406404
57PPARA_22158963_ChIP-Seq_LIVER_Mouse1.18129075
58RACK7_27058665_Chip-Seq_MCF-7_Human1.15970963
59MYC_22102868_ChIP-Seq_BL_Human1.15569253
60GATA4_25053715_ChIP-Seq_YYC3_Human1.15340020
61TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.15039579
62Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.13744203
63GATA2_22383799_ChIP-Seq_G1ME_Mouse1.13423481
64P63_26484246_Chip-Seq_KERATINOCYTES_Human1.11986423
65ESR2_21235772_ChIP-Seq_MCF-7_Human1.09673829
66CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08808917
67GATA1_19941826_ChIP-Seq_K562_Human1.08786565
68ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08320978
69LXR_22158963_ChIP-Seq_LIVER_Mouse1.07582757
70FOXO3_23340844_ChIP-Seq_DLD1_Human1.07086065
71VDR_24787735_ChIP-Seq_THP-1_Human1.05898305
72DNAJC2_21179169_ChIP-ChIP_NT2_Human1.05761547
73PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.05552967
74FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05348536
75KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04471783
76PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03255996
77MYB_26560356_Chip-Seq_TH1_Human1.01951999
78GATA2_21666600_ChIP-Seq_HMVEC_Human1.01675748
79GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01606277
80GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99435691
81STAT6_21828071_ChIP-Seq_BEAS2B_Human0.99218529
82CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98930189
83KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98097101
84DROSHA_22980978_ChIP-Seq_HELA_Human0.97988971
85GATA1_19941827_ChIP-Seq_MEL_Mouse0.97902391
86EGR1_19374776_ChIP-ChIP_THP-1_Human0.96909266
87ESR1_21235772_ChIP-Seq_MCF-7_Human0.96154024
88KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96151108
89GATA6_25053715_ChIP-Seq_YYC3_Human0.94219910
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93421124
91KDM2B_26808549_Chip-Seq_DND41_Human0.92592938
92LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.92483113
93BCOR_27268052_Chip-Seq_Bcells_Human0.91404129
94BCL6_27268052_Chip-Seq_Bcells_Human0.90400146
95NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.87311998
96SCL_19346495_ChIP-Seq_HPC-7_Human0.85965388
97GATA2_19941826_ChIP-Seq_K562_Human0.85621984
98NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.85314717
99BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.85025521
100PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83945113

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.79784987
2MP0003303_peritoneal_inflammation3.52916972
3MP0001835_abnormal_antigen_presentation3.26636338
4MP0003436_decreased_susceptibility_to3.24090243
5MP0005387_immune_system_phenotype2.96906230
6MP0001790_abnormal_immune_system2.96906230
7MP0010155_abnormal_intestine_physiology2.93937810
8MP0005025_abnormal_response_to2.66686991
9MP0010234_abnormal_vibrissa_follicle2.58575970
10MP0001800_abnormal_humoral_immune2.46369822
11MP0009785_altered_susceptibility_to2.44228551
12MP0000685_abnormal_immune_system2.41214086
13MP0000465_gastrointestinal_hemorrhage2.28205492
14MP0005671_abnormal_response_to2.21074846
15MP0001873_stomach_inflammation2.20678856
16MP0005000_abnormal_immune_tolerance2.18893278
17MP0002148_abnormal_hypersensitivity_rea2.10617684
18MP0001533_abnormal_skeleton_physiology2.09677895
19MP0005166_decreased_susceptibility_to2.08196454
20MP0003300_gastrointestinal_ulcer2.01732332
21MP0003866_abnormal_defecation1.99348486
22MP0002452_abnormal_antigen_presenting1.97180078
23MP0002419_abnormal_innate_immunity1.95941787
24MP0006082_CNS_inflammation1.95892973
25MP0004858_abnormal_nervous_system1.87977135
26MP0002723_abnormal_immune_serum1.84894590
27MP0004264_abnormal_extraembryonic_tissu1.83910821
28MP0002138_abnormal_hepatobiliary_system1.83211747
29MP0003191_abnormal_cellular_cholesterol1.79394706
30MP0004782_abnormal_surfactant_physiolog1.78615954
31MP0001819_abnormal_immune_cell1.77879618
32MP0002420_abnormal_adaptive_immunity1.76483591
33MP0004947_skin_inflammation1.70407650
34MP0005275_abnormal_skin_tensile1.69565072
35MP0001845_abnormal_inflammatory_respons1.68898277
36MP0010352_gastrointestinal_tract_polyps1.66805638
37MP0009840_abnormal_foam_cell1.61339096
38MP0002166_altered_tumor_susceptibility1.58625495
39MP0004510_myositis1.57211863
40MP0009333_abnormal_splenocyte_physiolog1.53503704
41MP0003183_abnormal_peptide_metabolism1.51261331
42MP0001663_abnormal_digestive_system1.50897987
43MP0008004_abnormal_stomach_pH1.46676992
44MP0008438_abnormal_cutaneous_collagen1.45007885
45MP0005360_urolithiasis1.40351060
46MP0005310_abnormal_salivary_gland1.37638655
47MP0000343_altered_response_to1.35953936
48MP0003075_altered_response_to1.35836745
49MP0003448_altered_tumor_morphology1.34253229
50MP0003763_abnormal_thymus_physiology1.32684484
51MP0002933_joint_inflammation1.28865318
52MP0000716_abnormal_immune_system1.28143698
53MP0000604_amyloidosis1.28122357
54MP0002277_abnormal_respiratory_mucosa1.27964813
55MP0003279_aneurysm1.26795482
56MP0005023_abnormal_wound_healing1.26037216
57MP0002139_abnormal_hepatobiliary_system1.25348230
58MP0002998_abnormal_bone_remodeling1.19699586
59MP0002405_respiratory_system_inflammati1.17983174
60MP0000858_altered_metastatic_potential1.17284872
61MP0008469_abnormal_protein_level1.16027833
62MP0009764_decreased_sensitivity_to1.15663004
63MP0003329_amyloid_beta_deposits1.12900073
64MP0009278_abnormal_bone_marrow1.12312563
65MP0002398_abnormal_bone_marrow1.11901466
66MP0002006_tumorigenesis1.10797586
67MP0005464_abnormal_platelet_physiology1.10660046
68MP0005381_digestive/alimentary_phenotyp1.10521581
69MP0001666_abnormal_nutrient_absorption1.09825739
70MP0005503_abnormal_tendon_morphology1.08294018
71MP0005390_skeleton_phenotype1.07387766
72MP0005058_abnormal_lysosome_morphology1.03989974
73MP0005085_abnormal_gallbladder_physiolo1.03632304
74MP0002796_impaired_skin_barrier1.03273263
75MP0000490_abnormal_crypts_of1.01648431
76MP0000477_abnormal_intestine_morphology1.01109916
77MP0001851_eye_inflammation0.99675491
78MP0002429_abnormal_blood_cell0.98313094
79MP0003453_abnormal_keratinocyte_physiol0.94148615
80MP0003806_abnormal_nucleotide_metabolis0.93773257
81MP0003045_fibrosis0.91922058
82MP0003828_pulmonary_edema0.91048908
83MP0005164_abnormal_response_to0.90555109
84MP0001664_abnormal_digestion0.89642527
85MP0005365_abnormal_bile_salt0.89552201
86MP0000249_abnormal_blood_vessel0.89092549
87MP0002722_abnormal_immune_system0.88309680
88MP0005451_abnormal_body_composition0.86920747
89MP0000689_abnormal_spleen_morphology0.85780220
90MP0001958_emphysema0.84515394
91MP0001986_abnormal_taste_sensitivity0.83410259
92MP0005165_increased_susceptibility_to0.81067714
93MP0002254_reproductive_system_inflammat0.80645194
94MP0005409_darkened_coat_color0.77868747
95MP0003868_abnormal_feces_composition0.77743218
96MP0003795_abnormal_bone_structure0.74059593
97MP0002876_abnormal_thyroid_physiology0.73132119
98MP0008260_abnormal_autophagy0.72239748
99MP0002896_abnormal_bone_mineralization0.70359353
100MP0002136_abnormal_kidney_physiology0.70274670

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)7.13193229
2Malnutrition (HP:0004395)5.18018820
3Prostate neoplasm (HP:0100787)4.90643445
4Abnormality of complement system (HP:0005339)4.83204502
5Abnormality of macrophages (HP:0004311)4.81687123
6Eczematoid dermatitis (HP:0000976)4.78330475
7Glomerulonephritis (HP:0000099)4.50570695
8Complement deficiency (HP:0004431)4.42187233
9Vasculitis (HP:0002633)3.80042630
10Nephritis (HP:0000123)3.73534495
11Colitis (HP:0002583)3.52770194
12Abnormality of the prostate (HP:0008775)3.49518456
13Recurrent bronchitis (HP:0002837)3.44506149
14Agammaglobulinemia (HP:0004432)3.39835725
15Increased IgE level (HP:0003212)3.34418852
16Gastrointestinal stroma tumor (HP:0100723)3.30164756
17Premature loss of primary teeth (HP:0006323)3.22787414
18Abnormal delayed hypersensitivity skin test (HP:0002963)3.20749552
19Spontaneous hematomas (HP:0007420)3.18926182
20Abnormality of the nasal mucosa (HP:0000433)3.11985206
21Inflammation of the large intestine (HP:0002037)3.06942307
22Meningitis (HP:0001287)3.06043053
23Recurrent bacterial skin infections (HP:0005406)3.03843192
24Recurrent abscess formation (HP:0002722)3.00583221
25Gastrointestinal infarctions (HP:0005244)2.97709217
26Cellulitis (HP:0100658)2.95433973
27Gingivitis (HP:0000230)2.95271742
28Myositis (HP:0100614)2.94684277
29Gastrointestinal inflammation (HP:0004386)2.93767335
30Abnormality of cells of the lymphoid lineage (HP:0012140)2.91264320
31Skin rash (HP:0000988)2.85845191
32Hemoptysis (HP:0002105)2.81300609
33Emphysema (HP:0002097)2.79456705
34Orchitis (HP:0100796)2.77815894
35Leukocytosis (HP:0001974)2.76056200
36Abnormality of small intestinal villus morphology (HP:0011472)2.74748474
37Villous atrophy (HP:0011473)2.74748474
38Chronic otitis media (HP:0000389)2.74641282
39Chronic obstructive pulmonary disease (HP:0006510)2.71385743
40Obstructive lung disease (HP:0006536)2.71385743
41Osteomyelitis (HP:0002754)2.68192354
42Elevated erythrocyte sedimentation rate (HP:0003565)2.65581516
43Abnormality of glutamine family amino acid metabolism (HP:0010902)2.65027290
44Urticaria (HP:0001025)2.64485958
45Recurrent gram-negative bacterial infections (HP:0005420)2.59224140
46Recurrent viral infections (HP:0004429)2.55591426
47Mediastinal lymphadenopathy (HP:0100721)2.52655114
48Chronic diarrhea (HP:0002028)2.52208471
49Abnormality of B cell number (HP:0010975)2.45396335
50Recurrent fungal infections (HP:0002841)2.44258359
51Pulmonary infiltrates (HP:0002113)2.42334044
52Fragile skin (HP:0001030)2.41411922
53Nasal polyposis (HP:0100582)2.36804160
54Purpura (HP:0000979)2.35590443
55Interstitial pulmonary disease (HP:0006530)2.35164507
56Recurrent skin infections (HP:0001581)2.33157251
57Ankyloglossia (HP:0010296)2.32757150
58Chronic mucocutaneous candidiasis (HP:0002728)2.31205283
59Recurrent cutaneous fungal infections (HP:0011370)2.31205283
60Right ventricular cardiomyopathy (HP:0011663)2.31079074
61Hypergammaglobulinemia (HP:0010702)2.27010172
62Optic neuritis (HP:0100653)2.25031224
63Retrobulbar optic neuritis (HP:0100654)2.25031224
64Pustule (HP:0200039)2.24234049
65Ileus (HP:0002595)2.20919791
66Atrophic scars (HP:0001075)2.18379795
67Hyperactive renin-angiotensin system (HP:0000841)2.17215314
68Recurrent sinusitis (HP:0011108)2.14284755
69Restrictive lung disease (HP:0002091)2.14164493
70Abnormality of monocarboxylic acid metabolism (HP:0010996)2.12469508
71Panhypogammaglobulinemia (HP:0003139)2.11964828
72Cheilitis (HP:0100825)2.10721448
73Hematochezia (HP:0002573)2.09854479
74Polygenic inheritance (HP:0010982)2.09353891
75Chest pain (HP:0100749)2.08938676
76Bronchitis (HP:0012387)2.03763254
77Periodontitis (HP:0000704)2.03506823
78Skin ulcer (HP:0200042)2.02283603
79Neoplasm of the lung (HP:0100526)2.01616606
80Abnormality of the pleura (HP:0002103)1.99531182
81Autoimmune thrombocytopenia (HP:0001973)1.98918791
82Autoimmune hemolytic anemia (HP:0001890)1.97267426
83Abnormality of male internal genitalia (HP:0000022)1.96782032
84Increased IgM level (HP:0003496)1.94668885
85Polycythemia (HP:0001901)1.94497765
86Encephalitis (HP:0002383)1.92048621
87Recurrent lower respiratory tract infections (HP:0002783)1.92042996
88Recurrent pneumonia (HP:0006532)1.91201788
89Hemorrhage of the eye (HP:0011885)1.89589653
90Alopecia of scalp (HP:0002293)1.89145315
91Abnormality of the peritoneum (HP:0002585)1.87873735
92Keratoconjunctivitis sicca (HP:0001097)1.87652642
93Hypermelanotic macule (HP:0001034)1.86343940
94Peritonitis (HP:0002586)1.86247791
95Abnormality of T cell number (HP:0011839)1.82957926
96Cerebral aneurysm (HP:0004944)1.82019827
97Abnormality of T cell physiology (HP:0011840)1.81674021
98Pulmonary embolism (HP:0002204)1.80737197
99Decreased circulating renin level (HP:0003351)1.80242631
100Lymphopenia (HP:0001888)1.78442819

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.82581449
2TYK23.59912988
3MAP4K13.30171592
4FGFR43.15906901
5MST1R3.03387061
6RIPK12.59005450
7BLK2.56921975
8EPHA32.43910160
9RIPK42.35529123
10CDC42BPA2.25602769
11JAK12.17597550
12EPHB12.12446257
13PRPF4B2.12301036
14IKBKE2.09392105
15KIT2.04490365
16JAK32.00622291
17FGFR31.81059386
18ZAP701.78788891
19FES1.76209682
20TBK11.71287072
21MAP3K141.69484723
22CSK1.62672957
23GRK61.51912764
24TXK1.49327462
25TGFBR21.36353911
26MAP3K11.32399427
27EPHB21.26659520
28JAK21.26220161
29IRAK41.26209620
30PDGFRA1.25199070
31SMG11.23772718
32PRKG21.21098083
33LYN1.17629441
34EPHA21.17020893
35TRIB31.15836913
36FER1.14059937
37MAP3K101.10442295
38DDR21.08992678
39MATK1.07188899
40SYK1.07018393
41PKN21.05221949
42IRAK11.03191020
43PTK61.01633187
44PIK3CA1.01203808
45TAOK10.96207537
46MET0.96148179
47BTK0.93644383
48MAP3K30.91647518
49HCK0.90938933
50CSF1R0.90248886
51SIK30.89368751
52NLK0.88991062
53MAP3K60.86507242
54ACVR1B0.86071279
55LCK0.81430769
56HIPK20.81134182
57MAP3K110.77937192
58STK240.75576941
59RET0.75183477
60MAP3K130.75137760
61MAPK70.72171075
62FGR0.71976329
63TNK20.71702224
64LRRK20.71245331
65IKBKB0.69676783
66STK390.67953311
67DMPK0.67633817
68MAP2K30.67133058
69GRK50.63933788
70PRKD20.61434342
71MYLK0.61187324
72FYN0.60880631
73PDPK10.59913210
74YES10.57582131
75OXSR10.57566658
76IRAK30.57259688
77PDGFRB0.57021239
78BMPR20.56441845
79MAPKAPK20.48975395
80MAP2K20.44852926
81PDK10.42843291
82TESK20.40538154
83BMX0.39610089
84ITK0.39214173
85KDR0.38749818
86LMTK20.37408192
87MAP3K20.37009897
88SRC0.34224975
89MAPK110.33933492
90MAPK40.33113608
91PAK40.33075462
92PRKCD0.31962132
93PDK20.30116567
94SIK10.30100462
95IGF1R0.29549576
96CDK60.28595802
97PRKD10.26977211
98MAPK30.26466819
99MAP3K70.26201424
100ABL10.24315759

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.07246041
2Asthma_Homo sapiens_hsa053103.70925613
3Allograft rejection_Homo sapiens_hsa053303.31061581
4Autoimmune thyroid disease_Homo sapiens_hsa053203.18349984
5Graft-versus-host disease_Homo sapiens_hsa053323.14850478
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.90776081
7Leishmaniasis_Homo sapiens_hsa051402.62327405
8Type I diabetes mellitus_Homo sapiens_hsa049402.57282214
9Antigen processing and presentation_Homo sapiens_hsa046122.34911792
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.30378802
11Cyanoamino acid metabolism_Homo sapiens_hsa004602.09128887
12Viral myocarditis_Homo sapiens_hsa054161.98184014
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.89874608
14Pertussis_Homo sapiens_hsa051331.82851685
15Toxoplasmosis_Homo sapiens_hsa051451.69790508
16Primary immunodeficiency_Homo sapiens_hsa053401.69659952
17Osteoclast differentiation_Homo sapiens_hsa043801.59997003
18Rheumatoid arthritis_Homo sapiens_hsa053231.55658852
19Hematopoietic cell lineage_Homo sapiens_hsa046401.48421352
20Tuberculosis_Homo sapiens_hsa051521.47114408
21Influenza A_Homo sapiens_hsa051641.46120564
22Other glycan degradation_Homo sapiens_hsa005111.40693675
23Fat digestion and absorption_Homo sapiens_hsa049751.30559791
24Arginine biosynthesis_Homo sapiens_hsa002201.29705179
25Complement and coagulation cascades_Homo sapiens_hsa046101.29461769
26Malaria_Homo sapiens_hsa051441.28387255
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.21934051
28B cell receptor signaling pathway_Homo sapiens_hsa046621.21782699
29Renin-angiotensin system_Homo sapiens_hsa046141.21072469
30Herpes simplex infection_Homo sapiens_hsa051681.18593719
31Chemokine signaling pathway_Homo sapiens_hsa040621.18555453
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.15350770
33TNF signaling pathway_Homo sapiens_hsa046681.12373760
34Phagosome_Homo sapiens_hsa041451.10167859
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.02432565
36Protein digestion and absorption_Homo sapiens_hsa049741.02243898
37African trypanosomiasis_Homo sapiens_hsa051431.00650320
38Hepatitis C_Homo sapiens_hsa051601.00611310
39Fructose and mannose metabolism_Homo sapiens_hsa000510.97219907
40Sulfur metabolism_Homo sapiens_hsa009200.96649306
41Leukocyte transendothelial migration_Homo sapiens_hsa046700.95779367
42Toll-like receptor signaling pathway_Homo sapiens_hsa046200.92823681
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92307748
44Measles_Homo sapiens_hsa051620.90543552
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.89095503
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.88429051
47Arachidonic acid metabolism_Homo sapiens_hsa005900.82064440
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81850501
49Amoebiasis_Homo sapiens_hsa051460.80467650
50Jak-STAT signaling pathway_Homo sapiens_hsa046300.79489255
51Mineral absorption_Homo sapiens_hsa049780.78131465
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76348535
53Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.74323989
54Prion diseases_Homo sapiens_hsa050200.70079377
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68666196
56Linoleic acid metabolism_Homo sapiens_hsa005910.68342277
57NOD-like receptor signaling pathway_Homo sapiens_hsa046210.67010467
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66880153
59Systemic lupus erythematosus_Homo sapiens_hsa053220.66333282
60Acute myeloid leukemia_Homo sapiens_hsa052210.65989308
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.65005262
62Caffeine metabolism_Homo sapiens_hsa002320.64309650
63Histidine metabolism_Homo sapiens_hsa003400.63216522
64Pancreatic secretion_Homo sapiens_hsa049720.61315637
65Lysosome_Homo sapiens_hsa041420.58903465
66Salmonella infection_Homo sapiens_hsa051320.57964973
67Ether lipid metabolism_Homo sapiens_hsa005650.54423958
68Vitamin digestion and absorption_Homo sapiens_hsa049770.52071766
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51648159
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.49235799
71Legionellosis_Homo sapiens_hsa051340.48020767
72Apoptosis_Homo sapiens_hsa042100.46302714
73Galactose metabolism_Homo sapiens_hsa000520.45814379
74PPAR signaling pathway_Homo sapiens_hsa033200.45678984
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45371925
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45057731
77Prolactin signaling pathway_Homo sapiens_hsa049170.43409172
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.43361145
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41772697
80HTLV-I infection_Homo sapiens_hsa051660.40527072
81Hepatitis B_Homo sapiens_hsa051610.39981843
82Starch and sucrose metabolism_Homo sapiens_hsa005000.39473818
83Platelet activation_Homo sapiens_hsa046110.39254264
84Pancreatic cancer_Homo sapiens_hsa052120.38567713
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.37673169
86T cell receptor signaling pathway_Homo sapiens_hsa046600.35519827
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.32877691
88VEGF signaling pathway_Homo sapiens_hsa043700.32605696
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32555859
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32463656
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32321273
92Epstein-Barr virus infection_Homo sapiens_hsa051690.30170023
93HIF-1 signaling pathway_Homo sapiens_hsa040660.30034286
94Thyroid hormone synthesis_Homo sapiens_hsa049180.29931696
95Arginine and proline metabolism_Homo sapiens_hsa003300.29340400
96Notch signaling pathway_Homo sapiens_hsa043300.27103146
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.26817267
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.24386431
99GnRH signaling pathway_Homo sapiens_hsa049120.24332289
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.23866179

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