IGLV6-57

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1complement activation, classical pathway (GO:0006958)9.50625622
2complement activation (GO:0006956)7.38863820
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.04672810
4rRNA catabolic process (GO:0016075)6.02037131
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.88154315
6antigen processing and presentation of endogenous antigen (GO:0019883)5.85453429
7immunoglobulin mediated immune response (GO:0016064)5.52094886
8T cell migration (GO:0072678)5.51211660
9positive regulation of respiratory burst (GO:0060267)5.32406259
10protein activation cascade (GO:0072376)5.31331344
11regulation of B cell receptor signaling pathway (GO:0050855)5.26053985
12cytidine metabolic process (GO:0046087)5.18881330
13cytidine catabolic process (GO:0006216)5.18881330
14cytidine deamination (GO:0009972)5.18881330
15humoral immune response (GO:0006959)5.01383389
16antibacterial humoral response (GO:0019731)4.82542828
17antimicrobial humoral response (GO:0019730)4.78441426
18B cell mediated immunity (GO:0019724)4.78218869
19regulation of dendritic cell antigen processing and presentation (GO:0002604)4.75925966
20glomerular filtration (GO:0003094)4.70807746
21pyrimidine ribonucleoside catabolic process (GO:0046133)4.64033098
22Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)4.55850676
23immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00024.55850676
24Fc-gamma receptor signaling pathway (GO:0038094)4.55850676
25Fc receptor mediated stimulatory signaling pathway (GO:0002431)4.52259808
26interferon-gamma-mediated signaling pathway (GO:0060333)4.47625003
27NIK/NF-kappaB signaling (GO:0038061)4.28839059
28renal filtration (GO:0097205)4.20115974
29type I interferon signaling pathway (GO:0060337)4.15334466
30cellular response to type I interferon (GO:0071357)4.15334466
31response to type I interferon (GO:0034340)4.10873433
32antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.97619601
33detection of bacterium (GO:0016045)3.95601298
34positive regulation of antigen processing and presentation (GO:0002579)3.80717486
35regulation of antigen processing and presentation (GO:0002577)3.79621787
36lymphocyte migration (GO:0072676)3.76826786
37mucosal immune response (GO:0002385)3.76685665
38NADH metabolic process (GO:0006734)3.76174448
39detection of other organism (GO:0098543)3.72997813
40dendritic cell chemotaxis (GO:0002407)3.71745576
41DNA deamination (GO:0045006)3.71219904
42T-helper 1 type immune response (GO:0042088)3.69053129
43regulation of respiratory burst (GO:0060263)3.68894608
44myeloid dendritic cell activation (GO:0001773)3.65806209
45cellular response to interferon-gamma (GO:0071346)3.59920733
46myeloid dendritic cell differentiation (GO:0043011)3.58544910
47positive thymic T cell selection (GO:0045059)3.57319091
48organ or tissue specific immune response (GO:0002251)3.51481749
49germinal center formation (GO:0002467)3.49658582
50negative thymic T cell selection (GO:0045060)3.49005980
51retina homeostasis (GO:0001895)3.40952089
52immune response-activating cell surface receptor signaling pathway (GO:0002429)3.38841897
53regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.36246638
54positive regulation of cellular response to oxidative stress (GO:1900409)3.34918871
55positive regulation of response to oxidative stress (GO:1902884)3.34918871
56CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.33710417
57negative regulation of cell killing (GO:0031342)3.31553643
58negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.31553643
59response to interferon-gamma (GO:0034341)3.30193960
60regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.29649134
61B cell receptor signaling pathway (GO:0050853)3.25419029
62positive regulation of B cell differentiation (GO:0045579)3.23912474
63negative T cell selection (GO:0043383)3.23311567
64positive regulation of gamma-delta T cell activation (GO:0046645)3.19633226
65dendritic cell migration (GO:0036336)3.15593903
66T cell costimulation (GO:0031295)3.06311084
67thymic T cell selection (GO:0045061)3.05899142
68chaperone mediated protein folding requiring cofactor (GO:0051085)3.03700664
69lymphocyte costimulation (GO:0031294)3.01764590
70respiratory burst (GO:0045730)3.00575304
71positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.99554113
72B cell homeostasis (GO:0001782)2.98457110
73negative regulation of B cell proliferation (GO:0030889)2.98430966
74positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.97945605
75B cell proliferation (GO:0042100)2.96532176
76adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.94228317
77regulation of alpha-beta T cell proliferation (GO:0046640)2.92784529
78antigen processing and presentation via MHC class Ib (GO:0002475)2.89913399
79regulation of cellular extravasation (GO:0002691)2.89593353
80defense response to protozoan (GO:0042832)2.89067945
81negative regulation of phagocytosis (GO:0050765)2.87150972
82production of molecular mediator of immune response (GO:0002440)2.86427637
83positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.85256078
84regulation of defense response to virus by host (GO:0050691)2.84761069
85regulation of T-helper 1 cell differentiation (GO:0045625)2.84206842
86regulation of interferon-beta biosynthetic process (GO:0045357)2.82553316
87poly(A)+ mRNA export from nucleus (GO:0016973)2.81667216
88T cell selection (GO:0045058)2.81539446
89innate immune response in mucosa (GO:0002227)2.77012695
90T cell lineage commitment (GO:0002360)2.74493693
91positive regulation of humoral immune response (GO:0002922)2.73766435
92response to interferon-beta (GO:0035456)2.71741407
93dendritic cell differentiation (GO:0097028)2.70610002
94negative regulation of mast cell activation (GO:0033004)2.68620967
95negative regulation of leukocyte mediated immunity (GO:0002704)2.65871746
96regulation of type I interferon-mediated signaling pathway (GO:0060338)2.64269844
97response to protozoan (GO:0001562)2.63591725
98negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.60269698
99immune response-activating signal transduction (GO:0002757)2.59590260
100negative regulation of viral genome replication (GO:0045071)2.57971486

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.36564292
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human6.44801288
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.41432667
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.79444591
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.78908684
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.32975965
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.30678335
8SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.19289262
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.16743719
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.03265684
11GATA1_22025678_ChIP-Seq_K562_Human2.96667779
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.88362127
13STAT4_19710469_ChIP-ChIP_TH1__Mouse2.62616052
14RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.59294600
15EGR1_23403033_ChIP-Seq_LIVER_Mouse2.55285116
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.40580604
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.40259532
18MYC_22102868_ChIP-Seq_BL_Human2.30540218
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.25823271
20MYB_26560356_Chip-Seq_TH2_Human2.22167054
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.19455575
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.17384013
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.12742187
24E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.05893192
25TP63_17297297_ChIP-ChIP_HaCaT_Human2.05191124
26SPI1_23547873_ChIP-Seq_NB4_Human1.89714155
27MYB_26560356_Chip-Seq_TH1_Human1.86207518
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.80599827
29MAF_26560356_Chip-Seq_TH1_Human1.79894962
30VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.74951851
31NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.72362312
32CIITA_25753668_ChIP-Seq_RAJI_Human1.67256574
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.66425114
34HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.61834307
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.59208930
36GATA3_26560356_Chip-Seq_TH2_Human1.58489863
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.57753119
38EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.52433575
39NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48866943
40STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.43954710
41RUNX_20019798_ChIP-Seq_JUKART_Human1.43174814
42UTX_26944678_Chip-Seq_JUKART_Human1.33996387
43VDR_21846776_ChIP-Seq_THP-1_Human1.33489489
44GATA3_27048872_Chip-Seq_THYMUS_Human1.29115661
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26298204
46PU.1_20513432_ChIP-Seq_Bcells_Mouse1.25206417
47TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24416656
48BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.22108132
49PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.19673334
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.16297711
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.16124144
52SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.15755618
53RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.15091347
54MYB_21317192_ChIP-Seq_ERMYB_Mouse1.14402122
55TRIM28_21343339_ChIP-Seq_HEK293_Human1.13735574
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11947248
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09682816
58CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07800805
59VDR_23849224_ChIP-Seq_CD4+_Human1.04288362
60BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03961661
61LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03449049
62VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02498095
63FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.01400773
64STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00971863
65VDR_24763502_ChIP-Seq_THP-1_Human1.00640563
66BCL6_27268052_Chip-Seq_Bcells_Human0.98983947
67AR_21909140_ChIP-Seq_LNCAP_Human0.98913292
68KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.97419000
69GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91918522
70TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90375018
71EST1_17652178_ChIP-ChIP_JURKAT_Human0.87727467
72LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.86797739
73CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85795592
74SPI1_23127762_ChIP-Seq_K562_Human0.85253218
75STAT1_20625510_ChIP-Seq_HELA_Human0.83584733
76HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.83487720
77EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.82364210
78SALL4_22934838_ChIP-ChIP_CD34+_Human0.82258046
79CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82217586
80P300_27268052_Chip-Seq_Bcells_Human0.81993748
81PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.81723829
82THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.80800103
83MAF_26560356_Chip-Seq_TH2_Human0.80471581
84CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.80261606
85SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80095705
86ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.75044270
87GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.74392778
88RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.74090628
89PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.73460074
90CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73436812
91ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.73407948
92BCOR_27268052_Chip-Seq_Bcells_Human0.72986909
93SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72433793
94CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.72213261
95ERG_20887958_ChIP-Seq_HPC-7_Mouse0.71154744
96ETS1_22383799_ChIP-Seq_G1ME_Mouse0.70556254
97TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.70025234
98CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.69805906
99PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.69730117
100IKZF1_21737484_ChIP-ChIP_HCT116_Human0.68483670

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000685_abnormal_immune_system4.93219227
2MP0001835_abnormal_antigen_presentation4.72794183
3MP0005387_immune_system_phenotype3.78584851
4MP0001790_abnormal_immune_system3.78584851
5MP0005671_abnormal_response_to3.68828872
6MP0002138_abnormal_hepatobiliary_system3.68168242
7MP0001800_abnormal_humoral_immune3.38877092
8MP0003724_increased_susceptibility_to3.35214389
9MP0002166_altered_tumor_susceptibility3.15532703
10MP0003303_peritoneal_inflammation2.85194578
11MP0003436_decreased_susceptibility_to2.82642050
12MP0005000_abnormal_immune_tolerance2.58652983
13MP0005025_abnormal_response_to2.57764844
14MP0002452_abnormal_antigen_presenting2.53907317
15MP0001348_abnormal_lacrimal_gland2.49138673
16MP0009785_altered_susceptibility_to2.39666717
17MP0002723_abnormal_immune_serum2.35246243
18MP0002006_tumorigenesis2.34208207
19MP0002148_abnormal_hypersensitivity_rea2.28114885
20MP0010155_abnormal_intestine_physiology2.27924212
21MP0002420_abnormal_adaptive_immunity2.26972393
22MP0001819_abnormal_immune_cell2.24791653
23MP0010234_abnormal_vibrissa_follicle2.23844371
24MP0000465_gastrointestinal_hemorrhage2.00241991
25MP0003763_abnormal_thymus_physiology1.97481630
26MP0000716_abnormal_immune_system1.82986932
27MP0005310_abnormal_salivary_gland1.82354449
28MP0002419_abnormal_innate_immunity1.82024183
29MP0002398_abnormal_bone_marrow1.79941786
30MP0006082_CNS_inflammation1.69345111
31MP0010352_gastrointestinal_tract_polyps1.67248249
32MP0003045_fibrosis1.63643348
33MP0001845_abnormal_inflammatory_respons1.62264370
34MP0001873_stomach_inflammation1.54873521
35MP0002429_abnormal_blood_cell1.53631143
36MP0009333_abnormal_splenocyte_physiolog1.52087440
37MP0002405_respiratory_system_inflammati1.51360990
38MP0001533_abnormal_skeleton_physiology1.51285589
39MP0003866_abnormal_defecation1.48479765
40MP0002396_abnormal_hematopoietic_system1.47631552
41MP0003693_abnormal_embryo_hatching1.44003733
42MP0004782_abnormal_surfactant_physiolog1.43332329
43MP0000689_abnormal_spleen_morphology1.42079351
44MP0004947_skin_inflammation1.40568263
45MP0002722_abnormal_immune_system1.37553071
46MP0002796_impaired_skin_barrier1.34788996
47MP0005275_abnormal_skin_tensile1.34526718
48MP0003191_abnormal_cellular_cholesterol1.19624210
49MP0003183_abnormal_peptide_metabolism1.19202060
50MP0005166_decreased_susceptibility_to1.18608939
51MP0003806_abnormal_nucleotide_metabolis1.12727677
52MP0003300_gastrointestinal_ulcer1.07948435
53MP0000703_abnormal_thymus_morphology1.06334979
54MP0005464_abnormal_platelet_physiology1.05294251
55MP0008469_abnormal_protein_level1.03174802
56MP0006036_abnormal_mitochondrial_physio1.02538103
57MP0003252_abnormal_bile_duct0.98565941
58MP0002139_abnormal_hepatobiliary_system0.97067114
59MP0005165_increased_susceptibility_to0.94266587
60MP0000343_altered_response_to0.92822498
61MP0001853_heart_inflammation0.92508007
62MP0002277_abnormal_respiratory_mucosa0.91841280
63MP0005645_abnormal_hypothalamus_physiol0.91107992
64MP0006035_abnormal_mitochondrial_morpho0.90620131
65MP0001663_abnormal_digestive_system0.90172389
66MP0002163_abnormal_gland_morphology0.85067259
67MP0003075_altered_response_to0.84378280
68MP0000490_abnormal_crypts_of0.83014186
69MP0010094_abnormal_chromosome_stability0.82725999
70MP0008438_abnormal_cutaneous_collagen0.81454062
71MP0000249_abnormal_blood_vessel0.77936333
72MP0008004_abnormal_stomach_pH0.77788632
73MP0003448_altered_tumor_morphology0.76960941
74MP0009840_abnormal_foam_cell0.76848950
75MP0002933_joint_inflammation0.73997165
76MP0005501_abnormal_skin_physiology0.72435426
77MP0000858_altered_metastatic_potential0.69632093
78MP0001216_abnormal_epidermal_layer0.69486137
79MP0003941_abnormal_skin_development0.68974624
80MP0009764_decreased_sensitivity_to0.68855147
81MP0001542_abnormal_bone_strength0.67299795
82MP0004510_myositis0.67268258
83MP0000613_abnormal_salivary_gland0.64568565
84MP0002136_abnormal_kidney_physiology0.64277607
85MP0002019_abnormal_tumor_incidence0.64042826
86MP0002998_abnormal_bone_remodeling0.63029980
87MP0004043_abnormal_pH_regulation0.62571769
88MP0005390_skeleton_phenotype0.61718404
89MP0003786_premature_aging0.60361878
90MP0009643_abnormal_urine_homeostasis0.60023573
91MP0003111_abnormal_nucleus_morphology0.57610116
92MP0002060_abnormal_skin_morphology0.56060894
93MP0003795_abnormal_bone_structure0.53089611
94MP0000477_abnormal_intestine_morphology0.51680319
95MP0003172_abnormal_lysosome_physiology0.51024968
96MP0001851_eye_inflammation0.50934934
97MP0005381_digestive/alimentary_phenotyp0.49865162
98MP0009763_increased_sensitivity_to0.49096590
99MP0003868_abnormal_feces_composition0.48737757
100MP0005451_abnormal_body_composition0.48716572

Predicted human phenotypes

RankGene SetZ-score
1Gastrointestinal stroma tumor (HP:0100723)5.45557624
2Recurrent bronchitis (HP:0002837)4.73570548
3Agammaglobulinemia (HP:0004432)4.71804521
4Prostate neoplasm (HP:0100787)4.25237073
5Vasculitis (HP:0002633)4.13258246
6Wrist flexion contracture (HP:0001239)4.02608175
7Eczematoid dermatitis (HP:0000976)3.99004707
8Abnormal delayed hypersensitivity skin test (HP:0002963)3.89559539
9Meningitis (HP:0001287)3.88891340
10Abnormality of the prostate (HP:0008775)3.79707683
11Systemic lupus erythematosus (HP:0002725)3.76722392
12Emphysema (HP:0002097)3.68383480
13Chronic sinusitis (HP:0011109)3.66182042
14Abnormality of cells of the lymphoid lineage (HP:0012140)3.58379780
15Enlarged penis (HP:0000040)3.36858086
16Increased IgE level (HP:0003212)3.36736265
17Chronic otitis media (HP:0000389)3.34888117
18Urticaria (HP:0001025)3.34619426
19Supernumerary spleens (HP:0009799)3.31605304
20Fair hair (HP:0002286)3.29172503
21IgA deficiency (HP:0002720)3.28121452
22Recurrent sinusitis (HP:0011108)3.16138227
23Cellulitis (HP:0100658)3.15110112
24Recurrent bacterial skin infections (HP:0005406)3.11402685
25Abnormality of macrophages (HP:0004311)3.09677496
26Papilloma (HP:0012740)3.09602104
27Verrucae (HP:0200043)3.09602104
28Panhypogammaglobulinemia (HP:0003139)3.08013937
29Osteomyelitis (HP:0002754)3.04079339
30Lymphopenia (HP:0001888)3.02484124
31Elevated erythrocyte sedimentation rate (HP:0003565)3.02360873
32Skin rash (HP:0000988)3.01594896
33Abnormality of the labia minora (HP:0012880)2.98919879
34Oligodactyly (hands) (HP:0001180)2.98155277
35Facial hemangioma (HP:0000329)2.93999730
36Ankle contracture (HP:0006466)2.88926585
37Chronic obstructive pulmonary disease (HP:0006510)2.87464098
38Obstructive lung disease (HP:0006536)2.87464098
39Premature loss of primary teeth (HP:0006323)2.83859148
40Recurrent gram-negative bacterial infections (HP:0005420)2.80635647
41Abnormality of complement system (HP:0005339)2.80592201
42Restrictive lung disease (HP:0002091)2.77210974
43Abnormality of placental membranes (HP:0011409)2.73194737
44Amniotic constriction ring (HP:0009775)2.73194737
45Recurrent viral infections (HP:0004429)2.72610182
46Abnormality of T cell physiology (HP:0011840)2.72160853
47Recurrent abscess formation (HP:0002722)2.69456520
48Malnutrition (HP:0004395)2.67817360
49Bronchitis (HP:0012387)2.66835591
50Oligodactyly (HP:0012165)2.65625788
51Recurrent lower respiratory tract infections (HP:0002783)2.61461503
52Neonatal death (HP:0003811)2.60836480
53Recurrent fungal infections (HP:0002841)2.59781430
54Esophageal neoplasm (HP:0100751)2.56756185
55Neoplasm of head and neck (HP:0012288)2.56756185
56Mediastinal lymphadenopathy (HP:0100721)2.55117630
57Gastrointestinal infarctions (HP:0005244)2.54492796
58Recurrent pneumonia (HP:0006532)2.52869298
59Hemoptysis (HP:0002105)2.52393298
60IgG deficiency (HP:0004315)2.52020978
61Chronic diarrhea (HP:0002028)2.51970273
62IgM deficiency (HP:0002850)2.51928727
63Generalized hypopigmentation of hair (HP:0011358)2.39848340
64Nephritis (HP:0000123)2.39700470
65Increased IgM level (HP:0003496)2.39260771
66Hypergammaglobulinemia (HP:0010702)2.33862932
67Erythema (HP:0010783)2.32643966
68Colitis (HP:0002583)2.31890030
69Increased serum pyruvate (HP:0003542)2.29516293
70Pulmonary infiltrates (HP:0002113)2.29386550
71Myositis (HP:0100614)2.27214011
72Abnormality of B cell number (HP:0010975)2.24785860
73Abnormality of T cells (HP:0002843)2.23904405
74Chest pain (HP:0100749)2.21144727
75Autoimmune hemolytic anemia (HP:0001890)2.17801043
76Autoimmune thrombocytopenia (HP:0001973)2.15956732
77Abnormality of glycolysis (HP:0004366)2.15300319
78Orchitis (HP:0100796)2.15184802
79Sepsis (HP:0100806)2.14191550
80Glomerulonephritis (HP:0000099)2.13756715
81Abnormality of the nasal mucosa (HP:0000433)2.13149499
82Hyperglycinemia (HP:0002154)2.11995601
83Recurrent skin infections (HP:0001581)2.10448243
84Skin ulcer (HP:0200042)2.08495327
85Inflammation of the large intestine (HP:0002037)2.04900979
86Chronic mucocutaneous candidiasis (HP:0002728)2.02759209
87Recurrent cutaneous fungal infections (HP:0011370)2.02759209
88Stillbirth (HP:0003826)2.01621877
89Retrobulbar optic neuritis (HP:0100654)2.01220435
90Optic neuritis (HP:0100653)2.01220435
91Oral leukoplakia (HP:0002745)1.99665393
92Lymphoma (HP:0002665)1.99484569
93Pulmonary fibrosis (HP:0002206)1.97481180
94Gangrene (HP:0100758)1.97254058
95Fetal akinesia sequence (HP:0001989)1.96616360
96Xerostomia (HP:0000217)1.96170502
97Cleft eyelid (HP:0000625)1.94228344
98Nasal polyposis (HP:0100582)1.93501478
99Cerebral palsy (HP:0100021)1.92797069
100Abnormality of male internal genitalia (HP:0000022)1.92439278

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CCNB14.25146234
2EIF2AK14.13087568
3VRK13.86258033
4TLK13.49922719
5NEK93.43862044
6EIF2AK33.28522139
7TAOK33.27605374
8ERN13.08172033
9VRK22.89728522
10SMG12.81668262
11TYK22.69257782
12MAP4K12.58440635
13RIPK42.49136971
14BLK2.31310087
15ZAK2.11950274
16MST42.02485708
17DAPK31.84469058
18SYK1.81157323
19TBK11.70285043
20TAF11.64461330
21GRK61.55942268
22KIT1.53138487
23IKBKE1.51636396
24JAK11.50384335
25BMPR21.40360607
26IRAK41.37417055
27BUB11.29513163
28IKBKB1.25136738
29LYN1.21797585
30MST1R1.20900139
31FGFR41.19434132
32PLK21.18636740
33JAK31.17440326
34PRPF4B1.08869158
35CSK1.07708715
36DAPK11.04445203
37EPHA30.98222130
38SIK30.96609162
39MAP3K140.95700434
40OXSR10.95187162
41FGFR30.92985941
42MAP3K80.92485345
43BTK0.92309312
44HIPK20.88858698
45STK100.88579250
46PLK30.87914120
47RPS6KA50.83667774
48PRKCI0.83250571
49NME10.82666559
50TXK0.81884784
51FES0.79377814
52MATK0.75682465
53PAK40.74452971
54EIF2AK20.72069696
55MAPKAPK20.69491547
56CSF1R0.68888459
57STK40.65426027
58JAK20.63849498
59PRKCH0.61023288
60CDC42BPA0.58421210
61PRKG20.58347769
62MAP3K30.58259320
63HCK0.57009987
64PRKCD0.56754177
65PIM10.56372500
66MAPK70.55537298
67PRKCQ0.54884664
68GRK50.53865396
69LCK0.53744872
70AURKA0.52614191
71TSSK60.52545610
72STK390.51340093
73RIPK10.50362206
74TNK20.45575932
75MAPKAPK50.41674967
76NUAK10.41390462
77MAP2K30.41034802
78MAPK40.38756980
79EPHB10.38686505
80RPS6KA40.37592275
81BCKDK0.36183221
82FER0.35208709
83AURKB0.35183433
84PTK60.32492935
85MELK0.32463462
86ALK0.29956367
87FGR0.29633588
88CSNK2A10.28950935
89GRK10.28937258
90ZAP700.27548938
91ABL10.26581491
92MAP3K10.26056438
93MAP3K20.25058528
94ITK0.23283993
95MAPK120.23111247
96PRKD10.22629404
97FYN0.21215283
98AKT20.19949924
99CAMKK10.19505685
100PDK20.19255947

Predicted pathways (KEGG)

RankGene SetZ-score
1Intestinal immune network for IgA production_Homo sapiens_hsa046725.74620588
2Asthma_Homo sapiens_hsa053104.45007169
3Allograft rejection_Homo sapiens_hsa053304.28341335
4Autoimmune thyroid disease_Homo sapiens_hsa053204.06654683
5Systemic lupus erythematosus_Homo sapiens_hsa053223.89954346
6Graft-versus-host disease_Homo sapiens_hsa053323.84884323
7Type I diabetes mellitus_Homo sapiens_hsa049403.33171937
8Staphylococcus aureus infection_Homo sapiens_hsa051503.25972114
9Primary immunodeficiency_Homo sapiens_hsa053402.90943837
10Antigen processing and presentation_Homo sapiens_hsa046122.90573672
11Viral myocarditis_Homo sapiens_hsa054162.56916623
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.37216555
13Leishmaniasis_Homo sapiens_hsa051402.24175612
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.79321077
15Proteasome_Homo sapiens_hsa030501.77112466
16B cell receptor signaling pathway_Homo sapiens_hsa046621.57096605
17Alcoholism_Homo sapiens_hsa050341.53103467
18Rheumatoid arthritis_Homo sapiens_hsa053231.52471591
19Herpes simplex infection_Homo sapiens_hsa051681.44452231
20Influenza A_Homo sapiens_hsa051641.38808735
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.29773715
22Vitamin B6 metabolism_Homo sapiens_hsa007501.21588720
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.20285211
24Toxoplasmosis_Homo sapiens_hsa051451.19255799
25Tuberculosis_Homo sapiens_hsa051521.16565830
26Hematopoietic cell lineage_Homo sapiens_hsa046401.15889509
27Osteoclast differentiation_Homo sapiens_hsa043801.06827205
28Epstein-Barr virus infection_Homo sapiens_hsa051691.01683029
29Viral carcinogenesis_Homo sapiens_hsa052030.99209039
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.98636693
31Other glycan degradation_Homo sapiens_hsa005110.97846823
32Phagosome_Homo sapiens_hsa041450.95916062
33Cyanoamino acid metabolism_Homo sapiens_hsa004600.95082652
34Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.92697083
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85559692
36Measles_Homo sapiens_hsa051620.85003986
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81145567
38Non-homologous end-joining_Homo sapiens_hsa034500.79590172
39Pentose phosphate pathway_Homo sapiens_hsa000300.76448325
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.74393985
41Apoptosis_Homo sapiens_hsa042100.73763087
42Protein export_Homo sapiens_hsa030600.67984338
43Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67337948
44TNF signaling pathway_Homo sapiens_hsa046680.65766940
45Pertussis_Homo sapiens_hsa051330.62505443
46Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61896208
47DNA replication_Homo sapiens_hsa030300.58797616
48HTLV-I infection_Homo sapiens_hsa051660.58780898
49Jak-STAT signaling pathway_Homo sapiens_hsa046300.56469361
50Base excision repair_Homo sapiens_hsa034100.55568968
51Hepatitis C_Homo sapiens_hsa051600.52948721
52Carbon metabolism_Homo sapiens_hsa012000.52521538
53Chemokine signaling pathway_Homo sapiens_hsa040620.50894702
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50517401
55Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50204352
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.49125808
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48867799
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48789993
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45787824
60RNA degradation_Homo sapiens_hsa030180.43702688
61Malaria_Homo sapiens_hsa051440.43472850
62Folate biosynthesis_Homo sapiens_hsa007900.42122391
63Mineral absorption_Homo sapiens_hsa049780.39370070
64Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.38924609
65Hepatitis B_Homo sapiens_hsa051610.38673459
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38177900
67Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37978757
68Sulfur metabolism_Homo sapiens_hsa009200.37786237
69Starch and sucrose metabolism_Homo sapiens_hsa005000.37330516
70African trypanosomiasis_Homo sapiens_hsa051430.32793779
71Caffeine metabolism_Homo sapiens_hsa002320.32310910
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.31877232
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30010069
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29294483
75Mismatch repair_Homo sapiens_hsa034300.28871082
76N-Glycan biosynthesis_Homo sapiens_hsa005100.27959856
77Glycerolipid metabolism_Homo sapiens_hsa005610.27222026
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26949189
79Fructose and mannose metabolism_Homo sapiens_hsa000510.25205381
80T cell receptor signaling pathway_Homo sapiens_hsa046600.24673979
81Parkinsons disease_Homo sapiens_hsa050120.24064568
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.22987458
83Legionellosis_Homo sapiens_hsa051340.21730903
84Pyruvate metabolism_Homo sapiens_hsa006200.21231643
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19874471
86Tryptophan metabolism_Homo sapiens_hsa003800.19573632
87Fat digestion and absorption_Homo sapiens_hsa049750.18224367
88Homologous recombination_Homo sapiens_hsa034400.18159308
89p53 signaling pathway_Homo sapiens_hsa041150.17437965
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.17388292
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.17349347
92Complement and coagulation cascades_Homo sapiens_hsa046100.16260455
93Histidine metabolism_Homo sapiens_hsa003400.13586394
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.13057278
95Biosynthesis of amino acids_Homo sapiens_hsa012300.12351513
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.11819499
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.11453487
98Sulfur relay system_Homo sapiens_hsa041220.10911140
99Arachidonic acid metabolism_Homo sapiens_hsa005900.10415430
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.07625304

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