IGLV5-45

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of respiratory burst (GO:0060267)8.72313195
2complement activation (GO:0006956)8.10075393
3glomerular filtration (GO:0003094)7.11406492
4renal filtration (GO:0097205)6.41717298
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.38311091
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.27054899
7antigen processing and presentation of endogenous antigen (GO:0019883)6.20675692
8protein activation cascade (GO:0072376)5.96839413
9regulation of respiratory burst (GO:0060263)5.77850074
10antibacterial humoral response (GO:0019731)5.45783686
11antimicrobial humoral response (GO:0019730)5.37119454
12Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)4.95423417
13immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00024.95423417
14Fc-gamma receptor signaling pathway (GO:0038094)4.95423417
15Fc receptor mediated stimulatory signaling pathway (GO:0002431)4.93619754
16regulation of cellular extravasation (GO:0002691)4.89914692
17humoral immune response (GO:0006959)4.82877551
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.68590138
19immunoglobulin mediated immune response (GO:0016064)4.12463135
20negative regulation of cell killing (GO:0031342)4.05325081
21negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.05325081
22detection of bacterium (GO:0016045)3.94077629
23regulation of dendritic cell antigen processing and presentation (GO:0002604)3.88527202
24detection of other organism (GO:0098543)3.85675268
25retina homeostasis (GO:0001895)3.71772895
26interferon-gamma-mediated signaling pathway (GO:0060333)3.68057531
27regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.66612796
28regulation of antigen processing and presentation (GO:0002577)3.55654533
29cellular response to type I interferon (GO:0071357)3.39552649
30type I interferon signaling pathway (GO:0060337)3.39552649
31response to type I interferon (GO:0034340)3.36795793
32positive regulation of pseudopodium assembly (GO:0031274)3.36169814
33NIK/NF-kappaB signaling (GO:0038061)3.34577605
34angiotensin maturation (GO:0002003)3.33681240
35positive regulation of antigen processing and presentation (GO:0002579)3.32002055
36chronic inflammatory response (GO:0002544)3.30636438
37germinal center formation (GO:0002467)3.29100811
38immune response-activating cell surface receptor signaling pathway (GO:0002429)3.24868448
39positive regulation of gamma-delta T cell activation (GO:0046645)3.22242100
40eosinophil chemotaxis (GO:0048245)3.20549512
41maintenance of gastrointestinal epithelium (GO:0030277)3.15558057
42modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.14806705
43positive regulation by organism of defense response of other organism involved in symbiotic interact3.14806705
44modulation by symbiont of host immune response (GO:0052553)3.14806705
45positive regulation by symbiont of host defense response (GO:0052509)3.14806705
46modulation by symbiont of host defense response (GO:0052031)3.14806705
47modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.14806705
48B cell mediated immunity (GO:0019724)3.11425626
49negative regulation of myotube differentiation (GO:0010832)3.09570099
50positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.04230999
51cellular response to interferon-gamma (GO:0071346)2.99363990
52regulation of pseudopodium assembly (GO:0031272)2.98906111
53positive regulation of Cdc42 GTPase activity (GO:0043089)2.97768961
54regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.97737413
55macrophage activation involved in immune response (GO:0002281)2.96764773
56regulation of interferon-beta biosynthetic process (GO:0045357)2.93473148
57eosinophil migration (GO:0072677)2.89714036
58detection of external biotic stimulus (GO:0098581)2.87756127
59response to interferon-gamma (GO:0034341)2.87622235
60dendritic cell chemotaxis (GO:0002407)2.87089261
61regulation of T cell tolerance induction (GO:0002664)2.85587939
62regulation of integrin activation (GO:0033623)2.84099444
63antigen processing and presentation via MHC class Ib (GO:0002475)2.83691049
64production of molecular mediator of immune response (GO:0002440)2.79152482
65GDP-mannose metabolic process (GO:0019673)2.75093141
66intestinal absorption (GO:0050892)2.71745339
67respiratory burst (GO:0045730)2.66073994
68myeloid dendritic cell differentiation (GO:0043011)2.64358932
69production of molecular mediator involved in inflammatory response (GO:0002532)2.62814612
70protein-chromophore linkage (GO:0018298)2.60591213
71regulation of necrotic cell death (GO:0010939)2.58319987
72interferon-gamma secretion (GO:0072643)2.58228006
73immune response-activating signal transduction (GO:0002757)2.57406592
74regulation of guanylate cyclase activity (GO:0031282)2.55002073
75activation of immune response (GO:0002253)2.53199629
76regulation of B cell receptor signaling pathway (GO:0050855)2.53031859
77regulation of tolerance induction (GO:0002643)2.52194558
78regulation of regulatory T cell differentiation (GO:0045589)2.52173574
79T-helper 1 type immune response (GO:0042088)2.51700559
80virion attachment to host cell (GO:0019062)2.50457485
81adhesion of symbiont to host cell (GO:0044650)2.50457485
82peptide catabolic process (GO:0043171)2.49969743
83positive regulation of T cell migration (GO:2000406)2.49105404
84dendritic cell migration (GO:0036336)2.48012921
85neutrophil activation involved in immune response (GO:0002283)2.47601603
86negative regulation of glycoprotein biosynthetic process (GO:0010561)2.42564014
87oligosaccharide biosynthetic process (GO:0009312)2.42458415
88myeloid dendritic cell activation (GO:0001773)2.42378495
89regulation of T cell migration (GO:2000404)2.41676634
90regulation of gamma-delta T cell activation (GO:0046643)2.41320065
91detection of biotic stimulus (GO:0009595)2.40412785
92positive regulation of type 2 immune response (GO:0002830)2.40221055
93B cell receptor signaling pathway (GO:0050853)2.39322749
94T cell costimulation (GO:0031295)2.37740910
95regulation of vitamin metabolic process (GO:0030656)2.36825700
96lymph node development (GO:0048535)2.36684955
97defense response to Gram-negative bacterium (GO:0050829)2.36671887
98positive thymic T cell selection (GO:0045059)2.36519652
99epithelial structure maintenance (GO:0010669)2.35917971
100complement activation, classical pathway (GO:0006958)10.1869102

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.95807907
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.06769201
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.76194806
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.16273700
5RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.10362504
6CDX2_20551321_ChIP-Seq_CACO-2_Human2.52427108
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.48522882
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.37656172
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.37007411
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.35381671
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.23959392
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.13213248
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.12118120
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.97514569
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.95859559
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.91160250
17SMAD_19615063_ChIP-ChIP_OVARY_Human1.90652844
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.84315531
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.81460614
20SOX2_27498859_Chip-Seq_STOMACH_Mouse1.80369533
21STAT4_19710469_ChIP-ChIP_TH1__Mouse1.77231887
22E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.75424941
23RUNX_20019798_ChIP-Seq_JUKART_Human1.74339563
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.71655722
25LXR_22292898_ChIP-Seq_THP-1_Human1.69905143
26TRIM28_21343339_ChIP-Seq_HEK293_Human1.63359045
27VDR_24763502_ChIP-Seq_THP-1_Human1.63199118
28BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.62656044
29MYB_21317192_ChIP-Seq_ERMYB_Mouse1.61497836
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.59852164
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.56602657
32SOX2_20726797_ChIP-Seq_SW620_Human1.50394055
33CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.46066990
34VDR_21846776_ChIP-Seq_THP-1_Human1.42652547
35FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.42139567
36TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40317875
37EGR1_19032775_ChIP-ChIP_M12_Human1.39701881
38ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.38869829
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.36767728
40GATA4_25053715_ChIP-Seq_YYC3_Human1.36717630
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.34633756
42Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.34324238
43MYB_26560356_Chip-Seq_TH2_Human1.33444755
44SPI1_23127762_ChIP-Seq_K562_Human1.31170246
45FOXO3_23340844_ChIP-Seq_DLD1_Human1.30540237
46RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.29596535
47CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29554360
48FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.28319250
49CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27699548
50BRD4_27068464_Chip-Seq_AML-cells_Mouse1.27420142
51RARG_19884340_ChIP-ChIP_MEFs_Mouse1.26478877
52RUNX1_22412390_ChIP-Seq_EML_Mouse1.26406151
53MAF_26560356_Chip-Seq_TH1_Human1.23964323
54PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.23452952
55PPARA_22158963_ChIP-Seq_LIVER_Mouse1.22285625
56SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22101552
57RXR_22158963_ChIP-Seq_LIVER_Mouse1.21571834
58SPI1_23547873_ChIP-Seq_NB4_Human1.21473333
59GATA6_25053715_ChIP-Seq_YYC3_Human1.19416725
60LXR_22158963_ChIP-Seq_LIVER_Mouse1.18100375
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.17823255
62VDR_24787735_ChIP-Seq_THP-1_Human1.17054545
63GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16296899
64PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.11044727
65ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10994565
66UTX_26944678_Chip-Seq_JUKART_Human1.10971930
67TCF7_22412390_ChIP-Seq_EML_Mouse1.10971182
68CLOCK_20551151_ChIP-Seq_293T_Human1.09627820
69MYB_26560356_Chip-Seq_TH1_Human1.07560534
70RACK7_27058665_Chip-Seq_MCF-7_Human1.07385110
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05190402
72GATA1_19941826_ChIP-Seq_K562_Human1.05015334
73LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04278670
74ESR2_21235772_ChIP-Seq_MCF-7_Human1.04028078
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02671390
76GATA1_19941827_ChIP-Seq_MEL_Mouse1.01741789
77ESR1_21235772_ChIP-Seq_MCF-7_Human1.01546992
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01354784
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00431556
80GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98784324
81GATA2_21666600_ChIP-Seq_HMVEC_Human0.98114048
82DROSHA_22980978_ChIP-Seq_HELA_Human0.98112935
83P63_26484246_Chip-Seq_KERATINOCYTES_Human0.97860350
84MYC_22102868_ChIP-Seq_BL_Human0.96922096
85BCL6_27268052_Chip-Seq_Bcells_Human0.94670735
86EGR1_19374776_ChIP-ChIP_THP-1_Human0.94593563
87KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94475134
88BCOR_27268052_Chip-Seq_Bcells_Human0.93918266
89DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93371032
90SCL_19346495_ChIP-Seq_HPC-7_Human0.92942122
91BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.92695632
92GATA2_19941826_ChIP-Seq_K562_Human0.92507010
93PPAR_26484153_Chip-Seq_NCI-H1993_Human0.92121758
94TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.92073980
95CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91199057
96NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89112583
97GATA3_27048872_Chip-Seq_THYMUS_Human0.87706510
98TCF4_18268006_ChIP-ChIP_LS174T_Human0.85993426
99LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.85661547
100PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85570760

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.27487035
2MP0001835_abnormal_antigen_presentation3.31586204
3MP0003303_peritoneal_inflammation3.29083088
4MP0010155_abnormal_intestine_physiology3.21206746
5MP0003436_decreased_susceptibility_to3.08309993
6MP0001790_abnormal_immune_system2.97981343
7MP0005387_immune_system_phenotype2.97981343
8MP0010234_abnormal_vibrissa_follicle2.82998267
9MP0001800_abnormal_humoral_immune2.54242337
10MP0005025_abnormal_response_to2.49755837
11MP0009785_altered_susceptibility_to2.39864461
12MP0003866_abnormal_defecation2.30711239
13MP0005671_abnormal_response_to2.27345340
14MP0005166_decreased_susceptibility_to2.21917900
15MP0000685_abnormal_immune_system2.21699621
16MP0001873_stomach_inflammation2.21573305
17MP0000465_gastrointestinal_hemorrhage2.21570082
18MP0005000_abnormal_immune_tolerance2.21414447
19MP0002138_abnormal_hepatobiliary_system2.20598026
20MP0002148_abnormal_hypersensitivity_rea2.12286757
21MP0004264_abnormal_extraembryonic_tissu2.09318074
22MP0006082_CNS_inflammation2.08298239
23MP0001533_abnormal_skeleton_physiology2.03574605
24MP0004858_abnormal_nervous_system2.03510944
25MP0002452_abnormal_antigen_presenting2.00928805
26MP0003183_abnormal_peptide_metabolism1.98148719
27MP0002419_abnormal_innate_immunity1.93462043
28MP0003300_gastrointestinal_ulcer1.92374849
29MP0002723_abnormal_immune_serum1.86500687
30MP0004782_abnormal_surfactant_physiolog1.83653752
31MP0001819_abnormal_immune_cell1.82695698
32MP0002420_abnormal_adaptive_immunity1.81191653
33MP0005360_urolithiasis1.80452586
34MP0001845_abnormal_inflammatory_respons1.75506118
35MP0001663_abnormal_digestive_system1.73373964
36MP0002139_abnormal_hepatobiliary_system1.68791132
37MP0003191_abnormal_cellular_cholesterol1.66690799
38MP0010352_gastrointestinal_tract_polyps1.66198809
39MP0004947_skin_inflammation1.64260999
40MP0005310_abnormal_salivary_gland1.55047430
41MP0009333_abnormal_splenocyte_physiolog1.53323035
42MP0002166_altered_tumor_susceptibility1.52827971
43MP0005085_abnormal_gallbladder_physiolo1.43719171
44MP0008004_abnormal_stomach_pH1.38195483
45MP0003075_altered_response_to1.36765887
46MP0002876_abnormal_thyroid_physiology1.35541169
47MP0003448_altered_tumor_morphology1.32413943
48MP0005381_digestive/alimentary_phenotyp1.29895255
49MP0000490_abnormal_crypts_of1.29709276
50MP0001664_abnormal_digestion1.28886097
51MP0000716_abnormal_immune_system1.27357388
52MP0001666_abnormal_nutrient_absorption1.26786310
53MP0003763_abnormal_thymus_physiology1.25901058
54MP0000604_amyloidosis1.25458660
55MP0000477_abnormal_intestine_morphology1.25073311
56MP0002998_abnormal_bone_remodeling1.22364716
57MP0005464_abnormal_platelet_physiology1.19852737
58MP0009840_abnormal_foam_cell1.19175162
59MP0000343_altered_response_to1.18733399
60MP0003329_amyloid_beta_deposits1.16922242
61MP0005023_abnormal_wound_healing1.16805151
62MP0009764_decreased_sensitivity_to1.16583634
63MP0002405_respiratory_system_inflammati1.15902294
64MP0005275_abnormal_skin_tensile1.15641160
65MP0002933_joint_inflammation1.15350329
66MP0008469_abnormal_protein_level1.14563738
67MP0002398_abnormal_bone_marrow1.13604692
68MP0004510_myositis1.11971901
69MP0003045_fibrosis1.08527648
70MP0002006_tumorigenesis1.08010446
71MP0003279_aneurysm1.06808646
72MP0005365_abnormal_bile_salt1.02779075
73MP0005390_skeleton_phenotype0.99620443
74MP0008438_abnormal_cutaneous_collagen0.99406597
75MP0002429_abnormal_blood_cell0.98696524
76MP0005503_abnormal_tendon_morphology0.98430026
77MP0009278_abnormal_bone_marrow0.97533633
78MP0000858_altered_metastatic_potential0.96692002
79MP0003806_abnormal_nucleotide_metabolis0.95889784
80MP0000678_abnormal_parathyroid_gland0.90603202
81MP0000249_abnormal_blood_vessel0.90229297
82MP0005164_abnormal_response_to0.89133809
83MP0005058_abnormal_lysosome_morphology0.87131050
84MP0000681_abnormal_thyroid_gland0.86775406
85MP0000689_abnormal_spleen_morphology0.86564990
86MP0002796_impaired_skin_barrier0.86551255
87MP0005165_increased_susceptibility_to0.86513185
88MP0002722_abnormal_immune_system0.83995669
89MP0002277_abnormal_respiratory_mucosa0.83719579
90MP0001851_eye_inflammation0.80765963
91MP0005451_abnormal_body_composition0.78442308
92MP0002136_abnormal_kidney_physiology0.77099027
93MP0002896_abnormal_bone_mineralization0.76914936
94MP0008260_abnormal_autophagy0.76905834
95MP0001986_abnormal_taste_sensitivity0.76893734
96MP0003252_abnormal_bile_duct0.76655238
97MP0003828_pulmonary_edema0.76146211
98MP0005409_darkened_coat_color0.75884094
99MP0009643_abnormal_urine_homeostasis0.74841177
100MP0001958_emphysema0.74278623

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)6.47655221
2Eczematoid dermatitis (HP:0000976)5.29414039
3Malnutrition (HP:0004395)5.03079964
4Abnormality of macrophages (HP:0004311)4.87459470
5Prostate neoplasm (HP:0100787)4.14299115
6Abnormality of complement system (HP:0005339)3.95436753
7Glomerulonephritis (HP:0000099)3.83119039
8Vasculitis (HP:0002633)3.81068808
9Agammaglobulinemia (HP:0004432)3.75042778
10Recurrent bronchitis (HP:0002837)3.69187281
11Complement deficiency (HP:0004431)3.67151522
12Cellulitis (HP:0100658)3.36579414
13Recurrent abscess formation (HP:0002722)3.34627352
14Recurrent bacterial skin infections (HP:0005406)3.33152276
15Gastrointestinal stroma tumor (HP:0100723)3.29991602
16Colitis (HP:0002583)3.25135878
17Meningitis (HP:0001287)3.24233924
18Spontaneous hematomas (HP:0007420)3.17222662
19Myositis (HP:0100614)3.16643042
20Abnormality of the prostate (HP:0008775)3.15327751
21Nephritis (HP:0000123)3.14790159
22Orchitis (HP:0100796)3.12454768
23Abnormal delayed hypersensitivity skin test (HP:0002963)3.07657818
24Abnormality of glutamine family amino acid metabolism (HP:0010902)3.05601042
25Osteomyelitis (HP:0002754)3.05224365
26Premature loss of primary teeth (HP:0006323)2.99704027
27Inflammation of the large intestine (HP:0002037)2.99475926
28Abnormality of the nasal mucosa (HP:0000433)2.97819182
29Gastrointestinal infarctions (HP:0005244)2.97720047
30Chronic diarrhea (HP:0002028)2.95371000
31Hyperactive renin-angiotensin system (HP:0000841)2.89582830
32Recurrent gram-negative bacterial infections (HP:0005420)2.89001322
33Abnormality of cells of the lymphoid lineage (HP:0012140)2.85845432
34Gastrointestinal inflammation (HP:0004386)2.85026855
35Abnormality of B cell number (HP:0010975)2.84116977
36Gingivitis (HP:0000230)2.83071741
37Skin rash (HP:0000988)2.81106934
38Mediastinal lymphadenopathy (HP:0100721)2.79408758
39Leukocytosis (HP:0001974)2.74728004
40Obstructive lung disease (HP:0006536)2.73491615
41Chronic obstructive pulmonary disease (HP:0006510)2.73491615
42Chronic otitis media (HP:0000389)2.71414477
43Elevated erythrocyte sedimentation rate (HP:0003565)2.70145437
44Urticaria (HP:0001025)2.65606235
45Hemoptysis (HP:0002105)2.61571127
46Decreased circulating renin level (HP:0003351)2.59198067
47Pulmonary infiltrates (HP:0002113)2.53951181
48Emphysema (HP:0002097)2.52724559
49Increased IgE level (HP:0003212)2.48914019
50Retrobulbar optic neuritis (HP:0100654)2.47229353
51Optic neuritis (HP:0100653)2.47229353
52Abnormality of monocarboxylic acid metabolism (HP:0010996)2.44725125
53Recurrent viral infections (HP:0004429)2.44582397
54Villous atrophy (HP:0011473)2.43388421
55Abnormality of small intestinal villus morphology (HP:0011472)2.43388421
56Recurrent fungal infections (HP:0002841)2.35078556
57Recurrent skin infections (HP:0001581)2.30760023
58Recurrent pneumonia (HP:0006532)2.30465761
59Recurrent sinusitis (HP:0011108)2.27660902
60Nasal polyposis (HP:0100582)2.26640384
61Bronchitis (HP:0012387)2.25878102
62Hemorrhage of the eye (HP:0011885)2.22209762
63Ileus (HP:0002595)2.22033485
64Purpura (HP:0000979)2.20166325
65Metabolic alkalosis (HP:0200114)2.19129353
66Alkalosis (HP:0001948)2.14813811
67Chest pain (HP:0100749)2.14750201
68Pustule (HP:0200039)2.14472041
69Autoimmune thrombocytopenia (HP:0001973)2.13870463
70Increased IgM level (HP:0003496)2.13583469
71Restrictive lung disease (HP:0002091)2.12970072
72Right ventricular cardiomyopathy (HP:0011663)2.11692815
73Polycythemia (HP:0001901)2.11644792
74Hematochezia (HP:0002573)2.11379785
75B lymphocytopenia (HP:0010976)2.11094446
76Recurrent lower respiratory tract infections (HP:0002783)2.09586261
77Abnormality of renin-angiotensin system (HP:0000847)2.05994456
78Verrucae (HP:0200043)2.03326851
79Papilloma (HP:0012740)2.03326851
80Peritonitis (HP:0002586)2.02492312
81Hypergammaglobulinemia (HP:0010702)2.01266584
82Encephalitis (HP:0002383)2.01082551
83Keratoconjunctivitis sicca (HP:0001097)2.00297813
84Chronic mucocutaneous candidiasis (HP:0002728)1.99079386
85Recurrent cutaneous fungal infections (HP:0011370)1.99079386
86Ankyloglossia (HP:0010296)1.98230183
87Skin ulcer (HP:0200042)1.96361219
88Abnormality of T cell number (HP:0011839)1.96193563
89Sepsis (HP:0100806)1.96147264
90Neoplasm of the lung (HP:0100526)1.95202692
91Abnormality of the pleura (HP:0002103)1.92795483
92Abnormality of the peritoneum (HP:0002585)1.91184885
93Gingival bleeding (HP:0000225)1.91035149
94Autoimmune hemolytic anemia (HP:0001890)1.88255114
95Lymphopenia (HP:0001888)1.86603828
96Pulmonary embolism (HP:0002204)1.85108940
97Fragile skin (HP:0001030)1.83857515
98Abnormality of male internal genitalia (HP:0000022)1.82491864
99Interstitial pulmonary disease (HP:0006530)1.80344930
100Segmental peripheral demyelination/remyelination (HP:0003481)1.79967108

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN16.41899989
2MST1R3.35258307
3TYK23.25338134
4MAP4K13.06225146
5BLK2.66614500
6RIPK12.66099558
7FGFR42.63338659
8RIPK42.56323657
9PRPF4B2.38954043
10EPHB12.15545880
11EPHA32.12409502
12ZAP701.93801659
13JAK31.91705751
14CDC42BPA1.82825123
15IKBKE1.80717010
16KIT1.79708706
17JAK11.77687284
18CSK1.69793222
19IRAK41.68723338
20PIK3CA1.67947884
21GRK61.55354278
22FES1.50337680
23MAP3K11.47071442
24FGFR31.44295993
25ACVR1B1.40812493
26EPHA21.38592792
27TXK1.34563239
28PRKG21.34040821
29TBK11.29694491
30JAK21.26582756
31EPHB21.26204966
32MAP3K141.24470344
33SYK1.23329674
34MAP3K101.22910973
35LYN1.20336217
36TGFBR21.18114400
37PTK61.12036657
38IRAK11.11742097
39MATK1.10905311
40MET1.10162774
41STK391.07273669
42TAOK11.02412591
43BTK0.99124842
44DDR20.97986139
45FER0.97844288
46MAP3K30.97796063
47MAP3K110.97520099
48SIK30.95328551
49HCK0.91624500
50MAP2K30.90974142
51OXSR10.89036969
52TRIB30.88264425
53PDGFRA0.87901973
54CSF1R0.86171524
55NLK0.81651964
56PKN20.80642984
57LCK0.79131235
58YES10.78911205
59LMTK20.78338328
60STK240.74215551
61IRAK30.73137660
62BMPR20.71913747
63FGR0.70504463
64PDPK10.69920053
65MAP3K120.68822504
66TESK20.68102108
67KSR20.67070051
68FYN0.66948304
69MAP3K130.66282010
70MYLK0.66080000
71RET0.64897078
72MAP3K60.60395358
73ADRBK20.59531019
74ITK0.59464286
75MAP3K20.58338499
76PDK10.54097103
77BMX0.53882500
78LRRK20.53307802
79KDR0.52624851
80TNK20.52415242
81MAPKAPK20.50493421
82HIPK20.49355247
83MAPK70.49006768
84MAPK110.48458005
85SMG10.47907069
86PDGFRB0.47800033
87MAP2K20.46108957
88IKBKB0.43698211
89TESK10.41192022
90TAOK20.38055349
91SRC0.36498042
92MAP2K60.35986262
93PAK40.34506524
94CDK60.34335318
95PRKCQ0.33186194
96TEC0.33156081
97PRKD20.32486518
98TAOK30.32245769
99ADRBK10.32055823
100DYRK1B0.31961195

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.76496847
2Asthma_Homo sapiens_hsa053103.54657337
3Allograft rejection_Homo sapiens_hsa053303.17704971
4Autoimmune thyroid disease_Homo sapiens_hsa053203.05036720
5Graft-versus-host disease_Homo sapiens_hsa053323.01229715
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.84890378
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.65122490
8Leishmaniasis_Homo sapiens_hsa051402.55293074
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.55008949
10Type I diabetes mellitus_Homo sapiens_hsa049402.44083694
11Antigen processing and presentation_Homo sapiens_hsa046122.18149206
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.11072901
13Viral myocarditis_Homo sapiens_hsa054161.87931182
14Pertussis_Homo sapiens_hsa051331.67188185
15Sulfur metabolism_Homo sapiens_hsa009201.65793409
16Fat digestion and absorption_Homo sapiens_hsa049751.60843381
17Primary immunodeficiency_Homo sapiens_hsa053401.60604955
18Arginine biosynthesis_Homo sapiens_hsa002201.55334499
19Toxoplasmosis_Homo sapiens_hsa051451.52122185
20Osteoclast differentiation_Homo sapiens_hsa043801.50302330
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.49743730
22Hematopoietic cell lineage_Homo sapiens_hsa046401.47364411
23Tuberculosis_Homo sapiens_hsa051521.42965966
24Rheumatoid arthritis_Homo sapiens_hsa053231.39891247
25Other glycan degradation_Homo sapiens_hsa005111.37066118
26Influenza A_Homo sapiens_hsa051641.29082654
27B cell receptor signaling pathway_Homo sapiens_hsa046621.27505256
28Renin-angiotensin system_Homo sapiens_hsa046141.24267553
29Fructose and mannose metabolism_Homo sapiens_hsa000511.21086602
30Complement and coagulation cascades_Homo sapiens_hsa046101.14475213
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.08495293
32Chemokine signaling pathway_Homo sapiens_hsa040621.06802839
33Phagosome_Homo sapiens_hsa041451.05526757
34Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04916371
35Herpes simplex infection_Homo sapiens_hsa051681.02527751
36Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.01799756
37Mineral absorption_Homo sapiens_hsa049781.01230162
38TNF signaling pathway_Homo sapiens_hsa046681.01145442
39Malaria_Homo sapiens_hsa051440.99249089
40Leukocyte transendothelial migration_Homo sapiens_hsa046700.98175404
41Protein digestion and absorption_Homo sapiens_hsa049740.97310214
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.93495648
43Toll-like receptor signaling pathway_Homo sapiens_hsa046200.93168491
44Hepatitis C_Homo sapiens_hsa051600.90601611
45Caffeine metabolism_Homo sapiens_hsa002320.89690706
46African trypanosomiasis_Homo sapiens_hsa051430.89081182
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86317733
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86248278
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.84997504
50Arachidonic acid metabolism_Homo sapiens_hsa005900.82550595
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82019753
52Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81771317
53Pancreatic secretion_Homo sapiens_hsa049720.79392706
54Galactose metabolism_Homo sapiens_hsa000520.77629393
55Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.73595913
56Measles_Homo sapiens_hsa051620.72755143
57Histidine metabolism_Homo sapiens_hsa003400.70470232
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69155203
59Starch and sucrose metabolism_Homo sapiens_hsa005000.68061887
60Jak-STAT signaling pathway_Homo sapiens_hsa046300.67402964
61Amoebiasis_Homo sapiens_hsa051460.64622425
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.62068630
63Salmonella infection_Homo sapiens_hsa051320.62043621
64Linoleic acid metabolism_Homo sapiens_hsa005910.61817473
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60447680
66NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59974579
67Lysosome_Homo sapiens_hsa041420.58530139
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57699348
69Acute myeloid leukemia_Homo sapiens_hsa052210.57374395
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56413968
71PPAR signaling pathway_Homo sapiens_hsa033200.56324514
72Systemic lupus erythematosus_Homo sapiens_hsa053220.53585454
73Ether lipid metabolism_Homo sapiens_hsa005650.50205503
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49753959
75RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49327845
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48571124
77Vitamin digestion and absorption_Homo sapiens_hsa049770.45630500
78Legionellosis_Homo sapiens_hsa051340.45165968
79Nitrogen metabolism_Homo sapiens_hsa009100.45081278
80Apoptosis_Homo sapiens_hsa042100.44377034
81Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43749230
82Fatty acid degradation_Homo sapiens_hsa000710.42824951
83Retinol metabolism_Homo sapiens_hsa008300.42143274
84Glycerolipid metabolism_Homo sapiens_hsa005610.41271143
85T cell receptor signaling pathway_Homo sapiens_hsa046600.41235680
86Prolactin signaling pathway_Homo sapiens_hsa049170.35370406
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35117980
88Platelet activation_Homo sapiens_hsa046110.34383843
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34262951
90Arginine and proline metabolism_Homo sapiens_hsa003300.33862579
91Thyroid hormone synthesis_Homo sapiens_hsa049180.32745355
92Hepatitis B_Homo sapiens_hsa051610.32549322
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.31174732
94Prion diseases_Homo sapiens_hsa050200.29962024
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.28994491
96HTLV-I infection_Homo sapiens_hsa051660.28627123
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28101886
98Bile secretion_Homo sapiens_hsa049760.27876192
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.27346009
100Chemical carcinogenesis_Homo sapiens_hsa052040.25126839

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