IGLV3-10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1complement activation (GO:0006956)9.29094637
2positive regulation of respiratory burst (GO:0060267)8.68193335
3glomerular filtration (GO:0003094)7.26633690
4protein activation cascade (GO:0072376)6.84154776
5renal filtration (GO:0097205)6.57308148
6regulation of respiratory burst (GO:0060263)5.88202199
7immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00025.82248350
8Fc-gamma receptor signaling pathway (GO:0038094)5.82248350
9Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)5.82248350
10Fc receptor mediated stimulatory signaling pathway (GO:0002431)5.79689481
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.34690873
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.28786763
13humoral immune response (GO:0006959)5.24364527
14antigen processing and presentation of endogenous antigen (GO:0019883)5.10302611
15retina homeostasis (GO:0001895)4.38536410
16antimicrobial humoral response (GO:0019730)4.37631419
17antibacterial humoral response (GO:0019731)4.35849977
18immunoglobulin mediated immune response (GO:0016064)4.24805189
19regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.20786038
20detection of bacterium (GO:0016045)4.03838767
21detection of other organism (GO:0098543)4.02315673
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.94890808
23interferon-gamma-mediated signaling pathway (GO:0060333)3.92585786
24negative regulation of cell killing (GO:0031342)3.89707678
25negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.89707678
26type I interferon signaling pathway (GO:0060337)3.78370880
27cellular response to type I interferon (GO:0071357)3.78370880
28regulation of cellular extravasation (GO:0002691)3.76793136
29response to type I interferon (GO:0034340)3.74451893
30regulation of antigen processing and presentation (GO:0002577)3.70879321
31immune response-activating cell surface receptor signaling pathway (GO:0002429)3.69405838
32germinal center formation (GO:0002467)3.69237327
33positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.67674814
34regulation of dendritic cell antigen processing and presentation (GO:0002604)3.60878068
35positive regulation of gamma-delta T cell activation (GO:0046645)3.47842636
36production of molecular mediator involved in inflammatory response (GO:0002532)3.22630142
37B cell mediated immunity (GO:0019724)3.20830251
38chronic inflammatory response (GO:0002544)3.19631535
39cellular response to interferon-gamma (GO:0071346)3.15098730
40positive regulation of antigen processing and presentation (GO:0002579)3.14920688
41detection of external biotic stimulus (GO:0098581)3.09452686
42negative regulation of myotube differentiation (GO:0010832)3.00481785
43response to interferon-gamma (GO:0034341)2.95682727
44surfactant homeostasis (GO:0043129)2.93874465
45immune response-activating signal transduction (GO:0002757)2.88560843
46protein-chromophore linkage (GO:0018298)2.86174128
47modulation by symbiont of host defense response (GO:0052031)2.85247140
48modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.85247140
49modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.85247140
50positive regulation by organism of defense response of other organism involved in symbiotic interact2.85247140
51modulation by symbiont of host immune response (GO:0052553)2.85247140
52positive regulation by symbiont of host defense response (GO:0052509)2.85247140
53activation of immune response (GO:0002253)2.82762859
54leukocyte aggregation (GO:0070486)2.78822098
55dendritic cell chemotaxis (GO:0002407)2.78251312
56myeloid dendritic cell differentiation (GO:0043011)2.74791039
57regulation of integrin activation (GO:0033623)2.74191096
58regulation of T cell tolerance induction (GO:0002664)2.73389418
59production of molecular mediator of immune response (GO:0002440)2.71436358
60negative regulation of complement activation (GO:0045916)2.70323714
61regulation of B cell receptor signaling pathway (GO:0050855)2.69275503
62regulation of gamma-delta T cell activation (GO:0046643)2.67231226
63interferon-gamma secretion (GO:0072643)2.66562224
64negative regulation of humoral immune response (GO:0002921)2.66430440
65regulation of regulatory T cell differentiation (GO:0045589)2.65593921
66respiratory burst (GO:0045730)2.64280415
67regulation of type I interferon-mediated signaling pathway (GO:0060338)2.63830213
68detection of biotic stimulus (GO:0009595)2.63242642
69macrophage activation involved in immune response (GO:0002281)2.61390828
70T-helper 1 type immune response (GO:0042088)2.55979263
71regulation of interferon-beta biosynthetic process (GO:0045357)2.54892518
72B cell receptor signaling pathway (GO:0050853)2.52501269
73positive regulation of Cdc42 GTPase activity (GO:0043089)2.52373639
74defense response to protozoan (GO:0042832)2.51968341
75NIK/NF-kappaB signaling (GO:0038061)2.51539139
76negative regulation of interleukin-12 production (GO:0032695)2.50602747
77cellular extravasation (GO:0045123)2.49956021
78myeloid dendritic cell activation (GO:0001773)2.48814954
79regulation of tolerance induction (GO:0002643)2.48656916
80response to interleukin-15 (GO:0070672)2.47568035
81response to interferon-beta (GO:0035456)2.43031258
82positive regulation of type 2 immune response (GO:0002830)2.42834643
83neutrophil activation involved in immune response (GO:0002283)2.41703988
84positive regulation of T cell migration (GO:2000406)2.41011633
85positive regulation of pseudopodium assembly (GO:0031274)2.39813364
86dendritic cell migration (GO:0036336)2.39040481
87negative regulation of protein activation cascade (GO:2000258)2.37817688
88adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.36456750
89regulation of macrophage chemotaxis (GO:0010758)2.34980653
90adhesion of symbiont to host cell (GO:0044650)2.34347289
91virion attachment to host cell (GO:0019062)2.34347289
92regulation of T cell migration (GO:2000404)2.34341775
93negative regulation of innate immune response (GO:0045824)2.34111451
94lymphocyte chemotaxis (GO:0048247)2.33744211
95wound healing, spreading of epidermal cells (GO:0035313)2.32405591
96regulation of necrotic cell death (GO:0010939)2.32315500
97negative regulation of bone resorption (GO:0045779)2.32310312
98regulation of gamma-delta T cell differentiation (GO:0045586)2.31472375
99leukocyte migration involved in inflammatory response (GO:0002523)2.31389983
100complement activation, classical pathway (GO:0006958)11.6929837

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.85611313
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.24358876
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.41527586
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.61600394
5RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.23213366
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.19197761
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.12238228
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.91848332
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.56905536
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.50790027
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.38107821
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.24911396
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.24376011
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.13616884
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.09159827
16CDX2_20551321_ChIP-Seq_CACO-2_Human1.98454942
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.97677438
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.96008645
19TRIM28_21343339_ChIP-Seq_HEK293_Human1.94647877
20MYB_21317192_ChIP-Seq_ERMYB_Mouse1.88909622
21STAT4_19710469_ChIP-ChIP_TH1__Mouse1.86862691
22SMAD_19615063_ChIP-ChIP_OVARY_Human1.86482383
23VDR_24763502_ChIP-Seq_THP-1_Human1.78909073
24RUNX_20019798_ChIP-Seq_JUKART_Human1.78735139
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.78693464
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.72664033
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.72319380
28VDR_21846776_ChIP-Seq_THP-1_Human1.64399250
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.60533356
30BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.58880968
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.58828218
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.52529516
33MYB_26560356_Chip-Seq_TH2_Human1.51206506
34SOX2_27498859_Chip-Seq_STOMACH_Mouse1.50758402
35Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.50528592
36FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.45935039
37LXR_22292898_ChIP-Seq_THP-1_Human1.45894983
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.45201228
39FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.42851573
40MAF_26560356_Chip-Seq_TH1_Human1.40459134
41TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40379594
42SPI1_23127762_ChIP-Seq_K562_Human1.39957159
43CLOCK_20551151_ChIP-Seq_293T_Human1.38207598
44VDR_24787735_ChIP-Seq_THP-1_Human1.34682486
45SPI1_23547873_ChIP-Seq_NB4_Human1.34284021
46ESR1_21235772_ChIP-Seq_MCF-7_Human1.34232425
47KDM2B_26808549_Chip-Seq_SUP-B15_Human1.33334123
48SOX2_20726797_ChIP-Seq_SW620_Human1.31854001
49BRD4_27068464_Chip-Seq_AML-cells_Mouse1.30405088
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.28278574
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.27250907
52FOXO3_23340844_ChIP-Seq_DLD1_Human1.27145685
53ESR2_21235772_ChIP-Seq_MCF-7_Human1.27120226
54EGR1_19032775_ChIP-ChIP_M12_Human1.25043621
55MYC_22102868_ChIP-Seq_BL_Human1.24931762
56CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21435595
57TCF7_22412390_ChIP-Seq_EML_Mouse1.19395745
58MYB_26560356_Chip-Seq_TH1_Human1.19294887
59UTX_26944678_Chip-Seq_JUKART_Human1.17957087
60GATA2_21666600_ChIP-Seq_HMVEC_Human1.16275320
61GATA1_22025678_ChIP-Seq_K562_Human1.15898875
62ELK3_25401928_ChIP-Seq_HUVEC_Human1.15750507
63MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.15061378
64RARG_19884340_ChIP-ChIP_MEFs_Mouse1.13989740
65GATA2_22383799_ChIP-Seq_G1ME_Mouse1.13905762
66CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11777658
67P63_26484246_Chip-Seq_KERATINOCYTES_Human1.11711754
68GATA4_25053715_ChIP-Seq_YYC3_Human1.07512015
69ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06693630
70CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04517536
71GATA1_19941826_ChIP-Seq_K562_Human1.04144936
72ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.04054034
73GATA3_27048872_Chip-Seq_THYMUS_Human1.01459895
74SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.01366768
75LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00575987
76STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00076474
77KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99761248
78SCL_19346495_ChIP-Seq_HPC-7_Human0.99487703
79LXR_22158963_ChIP-Seq_LIVER_Mouse0.98701429
80NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98451031
81PPARA_22158963_ChIP-Seq_LIVER_Mouse0.97812524
82RACK7_27058665_Chip-Seq_MCF-7_Human0.95412399
83SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95206231
84GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94085884
85KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93820520
86PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93461940
87PPAR_26484153_Chip-Seq_NCI-H1993_Human0.93015049
88RXR_22158963_ChIP-Seq_LIVER_Mouse0.92817745
89TCF4_18268006_ChIP-ChIP_LS174T_Human0.91196124
90PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89443675
91GATA1_19941827_ChIP-Seq_MEL_Mouse0.89375953
92PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87630898
93PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87477667
94GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87419018
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86605839
96KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.86549657
97GATA2_19941826_ChIP-Seq_K562_Human0.86392969
98CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85763016
99PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84675559
100GATA6_25053715_ChIP-Seq_YYC3_Human0.84551189

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.04162294
2MP0003303_peritoneal_inflammation3.67448641
3MP0003436_decreased_susceptibility_to3.60291806
4MP0001835_abnormal_antigen_presentation3.12548666
5MP0005387_immune_system_phenotype3.11692792
6MP0001790_abnormal_immune_system3.11692792
7MP0001800_abnormal_humoral_immune2.74030270
8MP0010155_abnormal_intestine_physiology2.61560519
9MP0005025_abnormal_response_to2.60018320
10MP0009785_altered_susceptibility_to2.56100683
11MP0005000_abnormal_immune_tolerance2.53858179
12MP0000685_abnormal_immune_system2.50186535
13MP0010234_abnormal_vibrissa_follicle2.46653050
14MP0005671_abnormal_response_to2.40660769
15MP0001533_abnormal_skeleton_physiology2.25952477
16MP0002148_abnormal_hypersensitivity_rea2.22436855
17MP0002452_abnormal_antigen_presenting2.22205039
18MP0002419_abnormal_innate_immunity2.16617819
19MP0002723_abnormal_immune_serum2.13273049
20MP0005275_abnormal_skin_tensile2.10128462
21MP0000465_gastrointestinal_hemorrhage2.05423172
22MP0005166_decreased_susceptibility_to2.04554142
23MP0001819_abnormal_immune_cell1.98121126
24MP0002420_abnormal_adaptive_immunity1.97686786
25MP0004947_skin_inflammation1.94923050
26MP0004782_abnormal_surfactant_physiolog1.92651599
27MP0003300_gastrointestinal_ulcer1.92459270
28MP0004264_abnormal_extraembryonic_tissu1.89546947
29MP0010352_gastrointestinal_tract_polyps1.79668030
30MP0002166_altered_tumor_susceptibility1.77524486
31MP0003866_abnormal_defecation1.76376138
32MP0001845_abnormal_inflammatory_respons1.74554612
33MP0001873_stomach_inflammation1.72454367
34MP0006082_CNS_inflammation1.69439236
35MP0008004_abnormal_stomach_pH1.65037852
36MP0003763_abnormal_thymus_physiology1.64362907
37MP0002138_abnormal_hepatobiliary_system1.62475875
38MP0008438_abnormal_cutaneous_collagen1.54985883
39MP0003191_abnormal_cellular_cholesterol1.54122369
40MP0009333_abnormal_splenocyte_physiolog1.53826153
41MP0003075_altered_response_to1.42556127
42MP0000716_abnormal_immune_system1.42549395
43MP0003448_altered_tumor_morphology1.40761846
44MP0005023_abnormal_wound_healing1.40608866
45MP0001663_abnormal_digestive_system1.37881683
46MP0005464_abnormal_platelet_physiology1.37728590
47MP0002405_respiratory_system_inflammati1.36190923
48MP0005310_abnormal_salivary_gland1.35679965
49MP0002006_tumorigenesis1.33919654
50MP0002398_abnormal_bone_marrow1.31799367
51MP0000343_altered_response_to1.29790524
52MP0005503_abnormal_tendon_morphology1.27160288
53MP0002796_impaired_skin_barrier1.25085760
54MP0002277_abnormal_respiratory_mucosa1.25069336
55MP0002998_abnormal_bone_remodeling1.24387265
56MP0004858_abnormal_nervous_system1.24329105
57MP0008469_abnormal_protein_level1.22903630
58MP0000858_altered_metastatic_potential1.22087960
59MP0005164_abnormal_response_to1.21730860
60MP0002933_joint_inflammation1.21404042
61MP0003279_aneurysm1.18863405
62MP0005390_skeleton_phenotype1.18789481
63MP0009764_decreased_sensitivity_to1.13384919
64MP0002429_abnormal_blood_cell1.11663260
65MP0000604_amyloidosis1.11659823
66MP0003183_abnormal_peptide_metabolism1.11100022
67MP0009278_abnormal_bone_marrow1.06867944
68MP0003828_pulmonary_edema1.06835632
69MP0003453_abnormal_keratinocyte_physiol1.05863760
70MP0003045_fibrosis1.05670423
71MP0001986_abnormal_taste_sensitivity1.04292573
72MP0005381_digestive/alimentary_phenotyp0.99362204
73MP0001851_eye_inflammation0.97986718
74MP0000689_abnormal_spleen_morphology0.97923679
75MP0002722_abnormal_immune_system0.97555005
76MP0000490_abnormal_crypts_of0.97087085
77MP0000249_abnormal_blood_vessel0.96559208
78MP0001542_abnormal_bone_strength0.93740116
79MP0000477_abnormal_intestine_morphology0.91688681
80MP0003329_amyloid_beta_deposits0.87420186
81MP0001958_emphysema0.83007079
82MP0003566_abnormal_cell_adhesion0.82295224
83MP0003795_abnormal_bone_structure0.81662575
84MP0009840_abnormal_foam_cell0.81292690
85MP0005165_increased_susceptibility_to0.79058592
86MP0004510_myositis0.78558090
87MP0002060_abnormal_skin_morphology0.78523021
88MP0003705_abnormal_hypodermis_morpholog0.75101373
89MP0001664_abnormal_digestion0.74509545
90MP0001216_abnormal_epidermal_layer0.74476452
91MP0002896_abnormal_bone_mineralization0.73618462
92MP0005388_respiratory_system_phenotype0.73453618
93MP0002133_abnormal_respiratory_system0.73453618
94MP0005409_darkened_coat_color0.71793536
95MP0002139_abnormal_hepatobiliary_system0.71145067
96MP0001545_abnormal_hematopoietic_system0.68823226
97MP0005397_hematopoietic_system_phenotyp0.68823226
98MP0002136_abnormal_kidney_physiology0.68633400
99MP0003091_abnormal_cell_migration0.68410661
100MP0001853_heart_inflammation0.66131943

Predicted human phenotypes

RankGene SetZ-score
1Prostate neoplasm (HP:0100787)6.53142608
2Systemic lupus erythematosus (HP:0002725)6.06210509
3Abnormality of macrophages (HP:0004311)5.35392204
4Eczematoid dermatitis (HP:0000976)4.58053894
5Abnormality of the prostate (HP:0008775)4.55284855
6Vasculitis (HP:0002633)4.03937485
7Abnormality of complement system (HP:0005339)3.82740070
8Abnormal delayed hypersensitivity skin test (HP:0002963)3.62688956
9Recurrent bronchitis (HP:0002837)3.62497782
10Agammaglobulinemia (HP:0004432)3.60786341
11Complement deficiency (HP:0004431)3.59642643
12Spontaneous hematomas (HP:0007420)3.58477607
13Glomerulonephritis (HP:0000099)3.57917195
14Malnutrition (HP:0004395)3.44544698
15Increased IgE level (HP:0003212)3.36253081
16Gastrointestinal stroma tumor (HP:0100723)3.36160171
17Recurrent bacterial skin infections (HP:0005406)3.33951578
18Abnormality of cells of the lymphoid lineage (HP:0012140)3.27820951
19Premature loss of primary teeth (HP:0006323)3.26939719
20Recurrent abscess formation (HP:0002722)3.18741897
21Leukocytosis (HP:0001974)3.17888541
22Meningitis (HP:0001287)3.14335424
23Colitis (HP:0002583)3.09963089
24Gastrointestinal infarctions (HP:0005244)3.04722363
25Myositis (HP:0100614)2.95348897
26Nephritis (HP:0000123)2.94014740
27Skin rash (HP:0000988)2.90663281
28Orchitis (HP:0100796)2.86763966
29Urticaria (HP:0001025)2.82555548
30Inflammation of the large intestine (HP:0002037)2.82553514
31Cellulitis (HP:0100658)2.81051208
32Hyperactive renin-angiotensin system (HP:0000841)2.79397693
33Gingivitis (HP:0000230)2.71639225
34Elevated erythrocyte sedimentation rate (HP:0003565)2.71012282
35Hemoptysis (HP:0002105)2.69569694
36Abnormality of male internal genitalia (HP:0000022)2.69397222
37Gastrointestinal inflammation (HP:0004386)2.68630164
38Osteomyelitis (HP:0002754)2.67058035
39Abnormality of the nasal mucosa (HP:0000433)2.60716225
40Panhypogammaglobulinemia (HP:0003139)2.59859186
41Interstitial pulmonary disease (HP:0006530)2.57195851
42Mediastinal lymphadenopathy (HP:0100721)2.56232614
43Chronic otitis media (HP:0000389)2.54554914
44Recurrent viral infections (HP:0004429)2.53866522
45Recurrent gram-negative bacterial infections (HP:0005420)2.48033620
46Recurrent skin infections (HP:0001581)2.47615045
47Pulmonary infiltrates (HP:0002113)2.47467752
48Hematochezia (HP:0002573)2.46983042
49Emphysema (HP:0002097)2.45598613
50Abnormality of small intestinal villus morphology (HP:0011472)2.43571400
51Villous atrophy (HP:0011473)2.43571400
52Optic neuritis (HP:0100653)2.42431127
53Retrobulbar optic neuritis (HP:0100654)2.42431127
54Chronic mucocutaneous candidiasis (HP:0002728)2.39128547
55Recurrent cutaneous fungal infections (HP:0011370)2.39128547
56Recurrent fungal infections (HP:0002841)2.38641309
57Hypergammaglobulinemia (HP:0010702)2.38559302
58Chronic obstructive pulmonary disease (HP:0006510)2.32091269
59Obstructive lung disease (HP:0006536)2.32091269
60Right ventricular cardiomyopathy (HP:0011663)2.30307082
61Alopecia of scalp (HP:0002293)2.29043773
62Bronchitis (HP:0012387)2.28904734
63Abnormality of B cell number (HP:0010975)2.28265169
64Chronic diarrhea (HP:0002028)2.27851405
65Neoplasm of the lung (HP:0100526)2.25063250
66Pustule (HP:0200039)2.20296351
67Periodontitis (HP:0000704)2.17988819
68Purpura (HP:0000979)2.16795642
69Recurrent lower respiratory tract infections (HP:0002783)2.16315148
70Increased IgM level (HP:0003496)2.15291669
71Abnormality of T cell physiology (HP:0011840)2.13719949
72Hypermelanotic macule (HP:0001034)2.12738185
73Keratoconjunctivitis sicca (HP:0001097)2.12456724
74Recurrent sinusitis (HP:0011108)2.12427503
75Abnormality of monocarboxylic acid metabolism (HP:0010996)2.08600190
76Skin ulcer (HP:0200042)2.04069545
77Restrictive lung disease (HP:0002091)2.03101849
78Autoimmune hemolytic anemia (HP:0001890)2.01493799
79Polycythemia (HP:0001901)2.00521863
80Fragile skin (HP:0001030)2.00341377
81Recurrent pneumonia (HP:0006532)2.00220456
82Metaphyseal cupping (HP:0003021)1.99874641
83Encephalitis (HP:0002383)1.99424522
84Autoimmune thrombocytopenia (HP:0001973)1.97309109
85Peritonitis (HP:0002586)1.97102955
86Esophageal neoplasm (HP:0100751)1.95077348
87Neoplasm of head and neck (HP:0012288)1.95077348
88Nasal polyposis (HP:0100582)1.94184183
89Segmental peripheral demyelination/remyelination (HP:0003481)1.94168315
90Abnormality of T cells (HP:0002843)1.93903553
91Gingival bleeding (HP:0000225)1.93709938
92Chest pain (HP:0100749)1.93689138
93Abnormality of T cell number (HP:0011839)1.93109623
94Abnormality of the peritoneum (HP:0002585)1.93011128
95Pulmonary embolism (HP:0002204)1.91790039
96Flat acetabular roof (HP:0003180)1.91392619
97Ankyloglossia (HP:0010296)1.90779454
98Keratoconjunctivitis (HP:0001096)1.89337091
99Neoplasm of the respiratory system (HP:0100606)1.89217708
100Lymphopenia (HP:0001888)1.87022834

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN17.41807716
2MAP4K13.15535163
3TYK23.12810124
4BLK3.02938223
5RIPK42.92883785
6MST1R2.87197361
7PRPF4B2.58503694
8FGFR42.43230494
9IKBKE2.11432022
10EPHA32.10022278
11RIPK12.05341859
12JAK11.98088179
13EPHB11.90241490
14TBK11.83814567
15CDC42BPA1.83685270
16KIT1.80725717
17ZAP701.79388148
18JAK31.74577189
19MAP3K141.67903358
20CSK1.63932515
21TXK1.61398489
22FES1.59054209
23PIK3CA1.55235008
24EPHA21.51441605
25FGFR31.49038535
26GRK61.46051312
27IRAK41.33393162
28NLK1.28849321
29LYN1.27991481
30JAK21.25747993
31SYK1.24091602
32YES11.18363962
33MAP2K31.12164838
34MATK1.10762650
35MAP3K11.09665786
36STK241.09244393
37SIK31.03568012
38HCK1.03219363
39FER0.98985033
40IRAK10.97870818
41PDGFRA0.97648451
42MAP3K30.97610393
43MAP2K20.95026866
44TGFBR20.93982817
45CSF1R0.91602160
46BTK0.91184498
47LRRK20.90364505
48BMPR20.86849483
49MET0.85620660
50MAP3K100.83153906
51IKBKB0.82623884
52PKN20.80457396
53MAP3K130.80186979
54DDR20.79530547
55TAOK10.79456788
56PTK60.74348070
57FGR0.73889539
58LCK0.71186751
59EPHB20.69507022
60IRAK30.69349438
61MAPK70.67203766
62SMG10.67000285
63IRAK20.65077860
64PDGFRB0.64821351
65TRIB30.64351777
66PDPK10.60859288
67MAP3K60.60085961
68FYN0.59380096
69RET0.57616350
70ACVR1B0.56488876
71PRKG20.56086291
72HIPK20.55525935
73TEC0.55143419
74LMTK20.54720621
75ADRBK20.54457594
76ITK0.52097955
77MAP2K60.51069506
78PDK10.48984475
79MAPKAPK20.47628516
80PAK40.47036005
81GRK50.44488031
82DMPK0.43221702
83TAOK30.41478345
84NEK90.41398832
85ABL10.39180708
86MYLK0.37749835
87TAOK20.36205740
88TNK20.36163268
89PRKCQ0.35693301
90STK100.35126470
91CDK60.34847150
92IGF1R0.34504098
93MELK0.32980888
94MAPK120.32578085
95MAP3K20.32478327
96MAPK40.32378268
97PRKCD0.30626176
98STK390.30152129
99KSR20.29439532
100TGFBR10.27337156

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.14711618
2Asthma_Homo sapiens_hsa053103.68763943
3Allograft rejection_Homo sapiens_hsa053303.40489937
4Autoimmune thyroid disease_Homo sapiens_hsa053203.24825479
5Graft-versus-host disease_Homo sapiens_hsa053323.19709531
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.00939597
7Leishmaniasis_Homo sapiens_hsa051402.83436802
8Type I diabetes mellitus_Homo sapiens_hsa049402.64086998
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.47111265
10Antigen processing and presentation_Homo sapiens_hsa046122.36559989
11Viral myocarditis_Homo sapiens_hsa054162.25044011
12Primary immunodeficiency_Homo sapiens_hsa053402.00276297
13Pertussis_Homo sapiens_hsa051331.81099866
14Toxoplasmosis_Homo sapiens_hsa051451.81012596
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.79468608
16Osteoclast differentiation_Homo sapiens_hsa043801.77382629
17Hematopoietic cell lineage_Homo sapiens_hsa046401.70002054
18Tuberculosis_Homo sapiens_hsa051521.70001174
19Influenza A_Homo sapiens_hsa051641.63396215
20Rheumatoid arthritis_Homo sapiens_hsa053231.62167489
21B cell receptor signaling pathway_Homo sapiens_hsa046621.48199016
22Malaria_Homo sapiens_hsa051441.43368951
23Complement and coagulation cascades_Homo sapiens_hsa046101.38373894
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.33555027
25Herpes simplex infection_Homo sapiens_hsa051681.27092302
26Phagosome_Homo sapiens_hsa041451.25141667
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.21927617
28TNF signaling pathway_Homo sapiens_hsa046681.20451862
29Measles_Homo sapiens_hsa051621.17759864
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.16311034
31Other glycan degradation_Homo sapiens_hsa005111.14801096
32Chemokine signaling pathway_Homo sapiens_hsa040621.14589810
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09820727
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.06649806
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.06510158
36Hepatitis C_Homo sapiens_hsa051601.06026192
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98935918
38African trypanosomiasis_Homo sapiens_hsa051430.96925924
39Jak-STAT signaling pathway_Homo sapiens_hsa046300.95404274
40Cyanoamino acid metabolism_Homo sapiens_hsa004600.95312709
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91103904
42Sulfur metabolism_Homo sapiens_hsa009200.90600700
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89741750
44Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.86078188
45NOD-like receptor signaling pathway_Homo sapiens_hsa046210.82754180
46Amoebiasis_Homo sapiens_hsa051460.81503990
47Arginine biosynthesis_Homo sapiens_hsa002200.80409842
48Legionellosis_Homo sapiens_hsa051340.78427240
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.77925402
50Acute myeloid leukemia_Homo sapiens_hsa052210.77850193
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77651974
52Arachidonic acid metabolism_Homo sapiens_hsa005900.69122854
53Salmonella infection_Homo sapiens_hsa051320.66857194
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63464953
55Apoptosis_Homo sapiens_hsa042100.62972472
56Hepatitis B_Homo sapiens_hsa051610.60278415
57Mineral absorption_Homo sapiens_hsa049780.60137089
58Renin-angiotensin system_Homo sapiens_hsa046140.59576802
59Protein digestion and absorption_Homo sapiens_hsa049740.58723203
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57617881
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57471134
62Lysosome_Homo sapiens_hsa041420.56582032
63T cell receptor signaling pathway_Homo sapiens_hsa046600.55559732
64Platelet activation_Homo sapiens_hsa046110.52292744
65Nitrogen metabolism_Homo sapiens_hsa009100.52078696
66Pancreatic cancer_Homo sapiens_hsa052120.51808928
67Systemic lupus erythematosus_Homo sapiens_hsa053220.50367660
68Fructose and mannose metabolism_Homo sapiens_hsa000510.47682423
69Pancreatic secretion_Homo sapiens_hsa049720.46686529
70Prolactin signaling pathway_Homo sapiens_hsa049170.45844764
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45754642
72Shigellosis_Homo sapiens_hsa051310.45744554
73HTLV-I infection_Homo sapiens_hsa051660.44872469
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43975386
75Fat digestion and absorption_Homo sapiens_hsa049750.41252292
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39762107
77HIF-1 signaling pathway_Homo sapiens_hsa040660.39636436
78Caffeine metabolism_Homo sapiens_hsa002320.39211566
79VEGF signaling pathway_Homo sapiens_hsa043700.39192727
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38298944
81Prion diseases_Homo sapiens_hsa050200.38163331
82Chronic myeloid leukemia_Homo sapiens_hsa052200.37971430
83Histidine metabolism_Homo sapiens_hsa003400.36665804
84Epstein-Barr virus infection_Homo sapiens_hsa051690.36153166
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34978121
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33337222
87PPAR signaling pathway_Homo sapiens_hsa033200.33109981
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.32921011
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30611632
90Renal cell carcinoma_Homo sapiens_hsa052110.30207885
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.29795651
92Endocytosis_Homo sapiens_hsa041440.29538076
93Sphingolipid metabolism_Homo sapiens_hsa006000.28489361
94Thyroid hormone synthesis_Homo sapiens_hsa049180.27965662
95GnRH signaling pathway_Homo sapiens_hsa049120.27068522
96Small cell lung cancer_Homo sapiens_hsa052220.26193473
97Linoleic acid metabolism_Homo sapiens_hsa005910.25335947
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.24037293
99Dorso-ventral axis formation_Homo sapiens_hsa043200.23371543
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.22769968

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