IGLV2-8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mesoderm development (GO:0007498)8.97897961
2mesenchyme development (GO:0060485)8.10627510
3gonadal mesoderm development (GO:0007506)60.5879449
4N-acetylneuraminate metabolic process (GO:0006054)5.90339137
5sex differentiation (GO:0007548)5.30461257
6nucleosome assembly (GO:0006334)5.08455893
7protein-DNA complex assembly (GO:0065004)4.26237208
8nucleosome organization (GO:0034728)4.04375027
9complement activation, classical pathway (GO:0006958)4.02094483
10protein-DNA complex subunit organization (GO:0071824)3.49098188
11complement activation (GO:0006956)3.04635268
12interleukin-6-mediated signaling pathway (GO:0070102)3.02518793
13regulation of isotype switching to IgG isotypes (GO:0048302)2.87600557
14regulation of activation of Janus kinase activity (GO:0010533)2.86677379
15apoptotic cell clearance (GO:0043277)2.85710505
16positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.83134165
17mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.83134165
18positive regulation of respiratory burst (GO:0060267)2.53542117
19positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.46272006
20Golgi transport vesicle coating (GO:0048200)2.33271634
21COPI coating of Golgi vesicle (GO:0048205)2.33271634
22amyloid precursor protein catabolic process (GO:0042987)2.33232105
23ribosomal small subunit biogenesis (GO:0042274)2.33109174
24sialylation (GO:0097503)2.31010748
25humoral immune response (GO:0006959)2.22341266
26positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.16627689
27protein activation cascade (GO:0072376)2.15305314
28amyloid precursor protein metabolic process (GO:0042982)2.14485093
29positive regulation of alpha-beta T cell proliferation (GO:0046641)2.05314256
30oligosaccharide catabolic process (GO:0009313)2.02219493
31positive regulation of viral genome replication (GO:0045070)2.00864287
32negative thymic T cell selection (GO:0045060)2.00793099
33cellular response to interleukin-6 (GO:0071354)1.99117386
34positive regulation of mitochondrial membrane permeability (GO:0035794)1.91693129
35ganglioside metabolic process (GO:0001573)1.88072298
36organ or tissue specific immune response (GO:0002251)1.87561872
37negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)1.87409429
38immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00021.86699968
39Fc-gamma receptor signaling pathway (GO:0038094)1.86699968
40Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)1.86699968
41Fc receptor mediated stimulatory signaling pathway (GO:0002431)1.84476404
42negative regulation of Notch signaling pathway (GO:0045746)1.83069163
43negative T cell selection (GO:0043383)1.80257168
44ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)1.79464282
45neutrophil mediated immunity (GO:0002446)1.78949194
46positive regulation of isotype switching (GO:0045830)1.78542723
47sodium ion homeostasis (GO:0055078)1.77732742
48cellular sodium ion homeostasis (GO:0006883)1.74947601
49protein K63-linked deubiquitination (GO:0070536)1.73800359
50protein N-linked glycosylation via asparagine (GO:0018279)1.73051095
51peptidyl-asparagine modification (GO:0018196)1.71557698
52regulation of alpha-beta T cell proliferation (GO:0046640)1.70705423
53protein localization to endoplasmic reticulum (GO:0070972)1.69648366
54regulation of respiratory burst (GO:0060263)1.69015706
55ER overload response (GO:0006983)1.67995358
56SRP-dependent cotranslational protein targeting to membrane (GO:0006614)1.67528561
57reproductive structure development (GO:0048608)1.65698021
58regulation of inflammatory response to antigenic stimulus (GO:0002861)1.65438464
59protein targeting to ER (GO:0045047)1.64928942
60COPII vesicle coating (GO:0048208)1.64641001
61cotranslational protein targeting to membrane (GO:0006613)1.63512824
62regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022351.62937791
63myeloid cell homeostasis (GO:0002262)1.62115073
64autophagic vacuole fusion (GO:0000046)1.61947826
65viral transcription (GO:0019083)1.61225748
66chaperone mediated protein folding requiring cofactor (GO:0051085)1.60038517
67establishment of protein localization to endoplasmic reticulum (GO:0072599)1.58905322
68protein N-linked glycosylation (GO:0006487)1.58827498
69response to interleukin-6 (GO:0070741)1.58722885
70Fc-epsilon receptor signaling pathway (GO:0038095)1.58678731
71cytokine biosynthetic process (GO:0042089)1.57778081
72protein K48-linked deubiquitination (GO:0071108)1.57323229
73amino sugar metabolic process (GO:0006040)1.56851749
74modulation by virus of host process (GO:0019054)1.56406572
75antibacterial humoral response (GO:0019731)1.56372783
76translational termination (GO:0006415)1.54353127
77negative regulation of interleukin-8 production (GO:0032717)1.54307902
78antimicrobial humoral response (GO:0019730)1.53660591
79amino sugar catabolic process (GO:0046348)1.53408722
80regulation of nuclease activity (GO:0032069)1.52927593
81monocyte chemotaxis (GO:0002548)1.52860910
82membrane protein intracellular domain proteolysis (GO:0031293)1.52675551
83positive regulation of DNA recombination (GO:0045911)1.52499597
84endoplasmic reticulum unfolded protein response (GO:0030968)1.51647298
85glycosphingolipid catabolic process (GO:0046479)1.49986830
86regulation of mitochondrial membrane permeability (GO:0046902)1.49432582
87response to endoplasmic reticulum stress (GO:0034976)1.48544147
88spermatogenesis (GO:0007283)1.47562150
89signal peptide processing (GO:0006465)1.47271685
90male gamete generation (GO:0048232)1.46713291
91activation of signaling protein activity involved in unfolded protein response (GO:0006987)1.46485228
92mitochondrial calcium ion transport (GO:0006851)1.45384583
93germinal center formation (GO:0002467)1.45201786
94translational elongation (GO:0006414)1.44559896
95cellular response to unfolded protein (GO:0034620)1.44426658
96regulation of cellular extravasation (GO:0002691)1.44221878
97regulation of defense response to virus by virus (GO:0050690)1.42932358
98cellular response to virus (GO:0098586)1.42849718
99positive regulation of nuclease activity (GO:0032075)1.42399050
100regulation of membrane permeability (GO:0090559)1.42307185

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.66230780
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.54340472
3E2F7_22180533_ChIP-Seq_HELA_Human3.42220260
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.01361381
5MYC_22102868_ChIP-Seq_BL_Human2.77440773
6TFEB_21752829_ChIP-Seq_HELA_Human2.77246176
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.67944020
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.59868630
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.49127873
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.38171998
11E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.37854648
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.20641215
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.07667812
14SREBP1_19666523_ChIP-Seq_LIVER_Mouse2.04464260
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.02776679
16CIITA_25753668_ChIP-Seq_RAJI_Human2.01777456
17CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.93521836
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.92519344
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.92226476
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.91893730
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.83698494
22EST1_17652178_ChIP-ChIP_JURKAT_Human1.82224038
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.77017670
24VDR_21846776_ChIP-Seq_THP-1_Human1.74079704
25THAP11_20581084_ChIP-Seq_MESCs_Mouse1.71623918
26SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.64030846
27ERG_20887958_ChIP-Seq_HPC-7_Mouse1.62412524
28ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.61502060
29MYC_19079543_ChIP-ChIP_MESCs_Mouse1.60862845
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.59287269
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58405024
32STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.58005208
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.57539572
34NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.57508811
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.52990778
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52354437
37SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.52295663
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51389606
39DCP1A_22483619_ChIP-Seq_HELA_Human1.48296113
40MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.46770454
41SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46621566
42NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46533442
43GABP_19822575_ChIP-Seq_HepG2_Human1.46528062
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45746659
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.43361611
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42827617
47MYC_18358816_ChIP-ChIP_MESCs_Mouse1.42735283
48CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.42656324
49PU.1_20513432_ChIP-Seq_Bcells_Mouse1.41868420
50XRN2_22483619_ChIP-Seq_HELA_Human1.41165016
51IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.41047032
52RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.40758201
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39458352
54MYB_26560356_Chip-Seq_TH2_Human1.38397130
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38259822
56DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.38184030
57VDR_24763502_ChIP-Seq_THP-1_Human1.36963639
58MYC_19030024_ChIP-ChIP_MESCs_Mouse1.35893296
59KDM5A_27292631_Chip-Seq_BREAST_Human1.35783664
60GATA2_22383799_ChIP-Seq_G1ME_Mouse1.35377083
61PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.34780812
62STAT1_20625510_ChIP-Seq_HELA_Human1.32527748
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32494881
64KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.29295214
65RUNX_20019798_ChIP-Seq_JUKART_Human1.28750037
66TTF2_22483619_ChIP-Seq_HELA_Human1.26871561
67MAF_26560356_Chip-Seq_TH2_Human1.26725757
68BP1_19119308_ChIP-ChIP_Hs578T_Human1.26417337
69ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.24623163
70MYB_26560356_Chip-Seq_TH1_Human1.24451524
71NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.23184247
72FOXP3_21729870_ChIP-Seq_TREG_Human1.22341692
73YY1_21170310_ChIP-Seq_MESCs_Mouse1.21554506
74PPARA_22158963_ChIP-Seq_LIVER_Mouse1.20940948
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20733643
76TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.17692697
77STAT4_19710469_ChIP-ChIP_TH1__Mouse1.16470883
78CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15216209
79MAF_26560356_Chip-Seq_TH1_Human1.14720767
80NELFA_20434984_ChIP-Seq_ESCs_Mouse1.13248038
81CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12796176
82FOXM1_23109430_ChIP-Seq_U2OS_Human1.12640892
83SPI1_23547873_ChIP-Seq_NB4_Human1.12459312
84SCL_19346495_ChIP-Seq_HPC-7_Human1.11524276
85CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.11464917
86PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11267203
87IRF8_27001747_Chip-Seq_BMDM_Mouse1.10656475
88FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.10604586
89E2F1_18555785_ChIP-Seq_MESCs_Mouse1.10111335
90MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09367268
91VDR_23849224_ChIP-Seq_CD4+_Human1.08923789
92IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.08551949
93LXR_22292898_ChIP-Seq_THP-1_Human1.05558212
94NCOR1_26117541_ChIP-Seq_K562_Human1.03028644
95ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.02628737
96UTX_26944678_Chip-Seq_JUKART_Human1.02485698
97POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.00640670
98GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99593837
99BCL6_27268052_Chip-Seq_Bcells_Human0.97380966
100SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96677744

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation9.38098172
2MP0005058_abnormal_lysosome_morphology3.98012629
3MP0009333_abnormal_splenocyte_physiolog3.60042054
4MP0003136_yellow_coat_color3.56581546
5MP0010234_abnormal_vibrissa_follicle3.06969949
6MP0009840_abnormal_foam_cell2.86951709
7MP0005451_abnormal_body_composition2.72545398
8MP0005671_abnormal_response_to2.58935267
9MP0005171_absent_coat_pigmentation2.41852311
10MP0000685_abnormal_immune_system2.36264444
11MP0001348_abnormal_lacrimal_gland2.31016268
12MP0001663_abnormal_digestive_system2.20034442
13MP0004043_abnormal_pH_regulation2.02266560
14MP0001800_abnormal_humoral_immune1.97885196
15MP0009785_altered_susceptibility_to1.95474408
16MP0003172_abnormal_lysosome_physiology1.93581092
17MP0001835_abnormal_antigen_presentation1.88608916
18MP0003763_abnormal_thymus_physiology1.86274417
19MP0002138_abnormal_hepatobiliary_system1.83648831
20MP0003183_abnormal_peptide_metabolism1.81691042
21MP0005025_abnormal_response_to1.72923497
22MP0005387_immune_system_phenotype1.71718094
23MP0001790_abnormal_immune_system1.71718094
24MP0005381_digestive/alimentary_phenotyp1.70250740
25MP0003693_abnormal_embryo_hatching1.57260069
26MP0003300_gastrointestinal_ulcer1.56991923
27MP0002168_other_aberrant_phenotype1.56648685
28MP0002148_abnormal_hypersensitivity_rea1.50656891
29MP0002452_abnormal_antigen_presenting1.49411109
30MP0005000_abnormal_immune_tolerance1.42934237
31MP0000465_gastrointestinal_hemorrhage1.40969091
32MP0010155_abnormal_intestine_physiology1.40591320
33MP0001845_abnormal_inflammatory_respons1.38455848
34MP0002796_impaired_skin_barrier1.35310320
35MP0006082_CNS_inflammation1.34988522
36MP0002420_abnormal_adaptive_immunity1.33826223
37MP0001819_abnormal_immune_cell1.33177345
38MP0001666_abnormal_nutrient_absorption1.31556398
39MP0002723_abnormal_immune_serum1.29152694
40MP0000716_abnormal_immune_system1.27535662
41MP0005464_abnormal_platelet_physiology1.27339547
42MP0010307_abnormal_tumor_latency1.26526469
43MP0005174_abnormal_tail_pigmentation1.25627665
44MP0003866_abnormal_defecation1.20138358
45MP0002398_abnormal_bone_marrow1.16650356
46MP0004264_abnormal_extraembryonic_tissu1.14600668
47MP0003868_abnormal_feces_composition1.14450404
48MP0000689_abnormal_spleen_morphology1.14237956
49MP0002429_abnormal_blood_cell1.11904194
50MP0004957_abnormal_blastocyst_morpholog1.10519685
51MP0003436_decreased_susceptibility_to1.07328918
52MP0000747_muscle_weakness1.06314600
53MP0005408_hypopigmentation1.04169170
54MP0005395_other_phenotype0.99872702
55MP0002419_abnormal_innate_immunity0.99560657
56MP0002090_abnormal_vision0.98095013
57MP0009643_abnormal_urine_homeostasis0.96677119
58MP0003111_abnormal_nucleus_morphology0.91663781
59MP0002166_altered_tumor_susceptibility0.88539619
60MP0000343_altered_response_to0.88374622
61MP0002722_abnormal_immune_system0.86456500
62MP0008569_lethality_at_weaning0.85023583
63MP0005085_abnormal_gallbladder_physiolo0.84470776
64MP0001873_stomach_inflammation0.82976807
65MP0010352_gastrointestinal_tract_polyps0.82148951
66MP0000490_abnormal_crypts_of0.81520523
67MP0001664_abnormal_digestion0.81299616
68MP0005166_decreased_susceptibility_to0.79094797
69MP0004947_skin_inflammation0.77382301
70MP0005360_urolithiasis0.77169615
71MP0002396_abnormal_hematopoietic_system0.77009391
72MP0003221_abnormal_cardiomyocyte_apopto0.75769108
73MP0001756_abnormal_urination0.74514684
74MP0000703_abnormal_thymus_morphology0.73430681
75MP0008469_abnormal_protein_level0.72672729
76MP0001851_eye_inflammation0.72531724
77MP0002693_abnormal_pancreas_physiology0.70840775
78MP0005310_abnormal_salivary_gland0.70538279
79MP0005584_abnormal_enzyme/coenzyme_acti0.69993592
80MP0005220_abnormal_exocrine_pancreas0.69778708
81MP0003724_increased_susceptibility_to0.69512224
82MP0002822_catalepsy0.68420541
83MP0003091_abnormal_cell_migration0.67491844
84MP0008004_abnormal_stomach_pH0.67029346
85MP0001542_abnormal_bone_strength0.66315316
86MP0003795_abnormal_bone_structure0.65909434
87MP0001186_pigmentation_phenotype0.65394222
88MP0005319_abnormal_enzyme/_coenzyme0.64026609
89MP0000313_abnormal_cell_death0.63235754
90MP0004808_abnormal_hematopoietic_stem0.62855272
91MP0001661_extended_life_span0.61900384
92MP0003045_fibrosis0.61564443
93MP0003453_abnormal_keratinocyte_physiol0.61081569
94MP0002139_abnormal_hepatobiliary_system0.60502251
95MP0000477_abnormal_intestine_morphology0.60070407
96MP0005670_abnormal_white_adipose0.59793216
97MP0004782_abnormal_surfactant_physiolog0.59326682
98MP0002896_abnormal_bone_mineralization0.59280755
99MP0008874_decreased_physiological_sensi0.58722144
100MP0002405_respiratory_system_inflammati0.57703428

Predicted human phenotypes

RankGene SetZ-score
1Increased cerebral lipofuscin (HP:0011813)5.18848921
2Vacuolated lymphocytes (HP:0001922)5.08078841
3Increased neuronal autofluorescent lipopigment (HP:0002074)5.06887008
4Abnormality of liposaccharide metabolism (HP:0010968)4.99302529
5Abnormality of glycosphingolipid metabolism (HP:0004343)4.99302529
6Abnormality of glycolipid metabolism (HP:0010969)4.99302529
7Hyperactive renin-angiotensin system (HP:0000841)4.68438311
8Decreased circulating renin level (HP:0003351)4.61693181
9Dysostosis multiplex (HP:0000943)4.19759641
10Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.18278917
11Vertebral compression fractures (HP:0002953)3.82020102
12Abnormal tarsal ossification (HP:0008369)3.71948748
13Large for gestational age (HP:0001520)3.57661835
14Ankyloglossia (HP:0010296)3.55982186
15Abnormal delayed hypersensitivity skin test (HP:0002963)3.46942510
16Albinism (HP:0001022)3.34153612
17Tetraparesis (HP:0002273)3.28994477
18Aplasia/Hypoplasia of the sacrum (HP:0008517)3.22877126
19Spinal cord lesions (HP:0100561)3.19697141
20Syringomyelia (HP:0003396)3.19697141
21Recurrent cutaneous fungal infections (HP:0011370)3.18975533
22Chronic mucocutaneous candidiasis (HP:0002728)3.18975533
23Patchy hypopigmentation of hair (HP:0011365)3.09776084
24Carpal bone hypoplasia (HP:0001498)3.08724657
25Ridged nail (HP:0001807)3.01735112
26Abnormality of the distal phalanges of the toes (HP:0010182)3.00828632
27Abnormality of macrophages (HP:0004311)2.92699081
28Autoimmune hemolytic anemia (HP:0001890)2.88299484
29Overlapping toe (HP:0001845)2.80681092
30Onycholysis (HP:0001806)2.76807560
31Abnormality of oral frenula (HP:0000190)2.73276225
32Urticaria (HP:0001025)2.66375455
33Thoracolumbar scoliosis (HP:0002944)2.60866942
34Abnormality of small intestinal villus morphology (HP:0011472)2.59827309
35Villous atrophy (HP:0011473)2.59827309
36Abnormal foot bone ossification (HP:0010675)2.56464690
37Systemic lupus erythematosus (HP:0002725)2.55127111
38Colitis (HP:0002583)2.53322689
39Hypokalemic alkalosis (HP:0001949)2.50862744
40Hyperkalemia (HP:0002153)2.48846038
41Dry hair (HP:0011359)2.48419056
42Small epiphyses (HP:0010585)2.46650950
43Abnormality of the lumbar spine (HP:0100712)2.45186757
44Erythema (HP:0010783)2.43839902
45Abnormality of incisor morphology (HP:0011063)2.40863076
46Spastic paraparesis (HP:0002313)2.40391445
47Microretrognathia (HP:0000308)2.40232830
48Long palpebral fissure (HP:0000637)2.35997658
49Deformed sella turcica (HP:0002681)2.31814834
50Abnormality of renin-angiotensin system (HP:0000847)2.30972791
51Reticulocytopenia (HP:0001896)2.29476573
52Curly hair (HP:0002212)2.28070083
53Progressive visual loss (HP:0000529)2.26463061
54Abnormality of mucopolysaccharide metabolism (HP:0011020)2.24333921
55Abnormality of polysaccharide metabolism (HP:0011012)2.24333921
56Abnormality of glycosaminoglycan metabolism (HP:0004371)2.24333921
57Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.23552887
58Chronic bronchitis (HP:0004469)2.22207705
59Exocrine pancreatic insufficiency (HP:0001738)2.21056864
60Abnormality of chloride homeostasis (HP:0011422)2.20338880
61White forelock (HP:0002211)2.20321140
62Exercise-induced myalgia (HP:0003738)2.18494025
63Thoracic kyphosis (HP:0002942)2.17757587
64Hyponatremia (HP:0002902)2.16543927
65Deep palmar crease (HP:0006191)2.15869866
66Lower limb hyperreflexia (HP:0002395)2.13607250
67Loss of speech (HP:0002371)2.12539535
68Recurrent viral infections (HP:0004429)2.12195579
69Increased IgE level (HP:0003212)2.11243846
70Hypercortisolism (HP:0001578)2.10559921
71Unilateral renal agenesis (HP:0000122)2.10136785
72Asymmetry of the thorax (HP:0001555)2.10118085
73Increased IgM level (HP:0003496)2.07691857
74Short middle phalanx of the 5th finger (HP:0004220)2.06789834
75Acute hepatic failure (HP:0006554)2.06475996
76Coarse hair (HP:0002208)2.05792529
77J-shaped sella turcica (HP:0002680)2.04562583
78Abnormal pupillary function (HP:0007686)2.03084738
79Alkalosis (HP:0001948)2.00815807
80Adrenal overactivity (HP:0002717)1.99496047
81Premature loss of primary teeth (HP:0006323)1.98536854
82Abnormal auditory evoked potentials (HP:0006958)1.98477331
83Paraparesis (HP:0002385)1.97348328
84Urinary glycosaminoglycan excretion (HP:0003541)1.95248521
85Mucopolysacchariduria (HP:0008155)1.95248521
86Visual hallucinations (HP:0002367)1.95050208
87Flattened epiphyses (HP:0003071)1.94348192
88Renal salt wasting (HP:0000127)1.93148175
89Hyperlipoproteinemia (HP:0010980)1.93117679
90Prolonged neonatal jaundice (HP:0006579)1.92987260
91Abnormal protein glycosylation (HP:0012346)1.92318227
92Abnormal glycosylation (HP:0012345)1.92318227
93Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.92318227
94Abnormal protein N-linked glycosylation (HP:0012347)1.92318227
95Progressive neurologic deterioration (HP:0002344)1.89711818
96Hyperaldosteronism (HP:0000859)1.88432172
97Type I transferrin isoform profile (HP:0003642)1.84853189
98Abnormality of T cell physiology (HP:0011840)1.84741871
99Abnormality of the thoracic spine (HP:0100711)1.82967821
100Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.80354123

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B6.98714560
2ERN15.00662778
3EIF2AK34.45105662
4ARAF3.28978431
5TAOK23.20278937
6KSR23.09542835
7IRAK32.91549761
8BRAF2.76905611
9MAP3K92.62684870
10NME22.53909254
11ITK2.47822891
12TESK22.40224707
13MAP3K132.35889551
14CDK192.19908280
15TAF11.94844240
16EEF2K1.84180573
17SCYL21.74983363
18MAPK71.65400540
19TYK21.64019826
20LRRK21.50826622
21MAP3K11.42192857
22MAP3K101.37442481
23MAP4K11.30938402
24KSR11.29383914
25CDK31.27620505
26RAF11.27306332
27TBK11.27210744
28GRK61.23870735
29MAP3K141.21876503
30MAP3K81.09663793
31IRAK41.08822229
32PDPK11.00092359
33MOS0.99276482
34IRAK20.92789122
35JAK10.87934187
36STK160.86428713
37MARK30.86180696
38FGFR40.84087535
39PDK10.83033346
40IRAK10.80617636
41MAP2K20.77506530
42MAPK120.77153703
43CSF1R0.73978179
44AKT20.72408929
45MAP3K20.71542614
46JAK20.69348110
47STK100.68184435
48MST40.67914846
49BRSK10.67238499
50SIK10.67093236
51IKBKE0.65833883
52ICK0.61106945
53FGFR30.55015736
54DYRK1B0.51373110
55TTK0.50873916
56MST1R0.50537290
57IKBKB0.50078656
58JAK30.47534589
59TAOK30.46547315
60CDK11A0.44532817
61ALK0.43763247
62ZAP700.42272699
63CDK80.41291943
64EIF2AK10.37854388
65BLK0.37753231
66MARK20.37276980
67PAK10.37136664
68CDK150.36999496
69RPS6KB10.35463931
70SIK30.35179163
71PRKCI0.33638395
72CDK140.33536520
73CSNK2A10.33295099
74NEK10.32791452
75SRPK10.32717360
76CDK180.32069829
77LMTK20.31217926
78NME10.30512088
79FES0.27843740
80PIM10.26627112
81MAP3K30.24762446
82HCK0.24339354
83MAP3K110.23638348
84PRKG20.22252374
85OXSR10.19876158
86PDK20.19694908
87MAP3K50.19142897
88ACVR1B0.18921653
89EPHA30.18784875
90LCK0.18658590
91PRKD20.17712968
92MAPKAPK20.17560562
93SYK0.17357285
94MAP2K10.16875510
95CDK70.15835910
96MAP2K30.15700168
97DAPK20.15313430
98MELK0.13757435
99CHEK10.13715916
100PRKCQ0.13666955

Predicted pathways (KEGG)

RankGene SetZ-score
1Intestinal immune network for IgA production_Homo sapiens_hsa046724.98636473
2N-Glycan biosynthesis_Homo sapiens_hsa005104.52963211
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.23099036
4Allograft rejection_Homo sapiens_hsa053302.77876019
5Autoimmune thyroid disease_Homo sapiens_hsa053202.72583145
6Graft-versus-host disease_Homo sapiens_hsa053322.58437673
7Other glycan degradation_Homo sapiens_hsa005112.37479446
8Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.27690844
9Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.12135835
10Sulfur metabolism_Homo sapiens_hsa009202.10822989
11Vibrio cholerae infection_Homo sapiens_hsa051102.10063958
12Cyanoamino acid metabolism_Homo sapiens_hsa004602.04023586
13Ribosome_Homo sapiens_hsa030102.03871085
14Type I diabetes mellitus_Homo sapiens_hsa049402.00042752
15Rheumatoid arthritis_Homo sapiens_hsa053231.99127918
16Lysosome_Homo sapiens_hsa041421.96425714
17Bladder cancer_Homo sapiens_hsa052191.86520991
18Proteasome_Homo sapiens_hsa030501.83622435
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.81581370
20Acute myeloid leukemia_Homo sapiens_hsa052211.75813829
21Collecting duct acid secretion_Homo sapiens_hsa049661.57633958
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.56074916
23Viral myocarditis_Homo sapiens_hsa054161.51517471
24Non-small cell lung cancer_Homo sapiens_hsa052231.41747154
25Asthma_Homo sapiens_hsa053101.38433416
26Prion diseases_Homo sapiens_hsa050201.37118800
27DNA replication_Homo sapiens_hsa030301.37117538
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.33848565
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.32189019
30Staphylococcus aureus infection_Homo sapiens_hsa051501.27159518
31Antigen processing and presentation_Homo sapiens_hsa046121.18900790
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.18032557
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.12434207
34B cell receptor signaling pathway_Homo sapiens_hsa046621.09566918
35Measles_Homo sapiens_hsa051621.07411808
36T cell receptor signaling pathway_Homo sapiens_hsa046601.03528457
37Hepatitis C_Homo sapiens_hsa051600.99756104
38Hepatitis B_Homo sapiens_hsa051610.99070293
39Influenza A_Homo sapiens_hsa051640.97301316
40Pancreatic cancer_Homo sapiens_hsa052120.96945743
41Chronic myeloid leukemia_Homo sapiens_hsa052200.95989181
42Renin-angiotensin system_Homo sapiens_hsa046140.92544131
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89890544
44Leishmaniasis_Homo sapiens_hsa051400.89149948
45Endometrial cancer_Homo sapiens_hsa052130.88119143
46Toll-like receptor signaling pathway_Homo sapiens_hsa046200.87352288
47Herpes simplex infection_Homo sapiens_hsa051680.82718706
48Thyroid cancer_Homo sapiens_hsa052160.82318815
49Protein export_Homo sapiens_hsa030600.77928339
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74101014
51Prostate cancer_Homo sapiens_hsa052150.72476537
52Oxidative phosphorylation_Homo sapiens_hsa001900.71469970
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68702849
54Dorso-ventral axis formation_Homo sapiens_hsa043200.68337263
55Apoptosis_Homo sapiens_hsa042100.66311549
56Vitamin B6 metabolism_Homo sapiens_hsa007500.66113677
57Tuberculosis_Homo sapiens_hsa051520.64954658
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63209216
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.62652887
60Primary immunodeficiency_Homo sapiens_hsa053400.62594602
61Phagosome_Homo sapiens_hsa041450.62421872
62Sphingolipid metabolism_Homo sapiens_hsa006000.62329288
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61811209
64Base excision repair_Homo sapiens_hsa034100.61286808
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.58658640
66Glioma_Homo sapiens_hsa052140.58118150
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57497261
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54613632
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54148423
70One carbon pool by folate_Homo sapiens_hsa006700.53737031
71HTLV-I infection_Homo sapiens_hsa051660.53036996
72Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50949524
73Chemokine signaling pathway_Homo sapiens_hsa040620.50728423
74Toxoplasmosis_Homo sapiens_hsa051450.49882531
75Arginine biosynthesis_Homo sapiens_hsa002200.49768034
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49640080
77Synaptic vesicle cycle_Homo sapiens_hsa047210.49427416
78Parkinsons disease_Homo sapiens_hsa050120.49271788
79Fatty acid elongation_Homo sapiens_hsa000620.47485022
80Renal cell carcinoma_Homo sapiens_hsa052110.46917389
81Epstein-Barr virus infection_Homo sapiens_hsa051690.46331106
82FoxO signaling pathway_Homo sapiens_hsa040680.44107862
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.43330765
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42519631
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42491378
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38521791
87Osteoclast differentiation_Homo sapiens_hsa043800.36449405
88Galactose metabolism_Homo sapiens_hsa000520.36333427
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.35921673
90Pyrimidine metabolism_Homo sapiens_hsa002400.35548626
91Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33318248
922-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.32946759
93Fructose and mannose metabolism_Homo sapiens_hsa000510.32327212
94Sulfur relay system_Homo sapiens_hsa041220.31398414
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31164276
96VEGF signaling pathway_Homo sapiens_hsa043700.30518999
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.28227928
98Alzheimers disease_Homo sapiens_hsa050100.27954404
99Malaria_Homo sapiens_hsa051440.27926855
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.27706266

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