IGLL5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the immunoglobulin lambda-like polypeptides. It is located within the immunoglobulin lambda locus but it does not require somatic rearrangement for expression. The first exon of this gene is unrelated to immunoglobulin variable genes; the second and third exons are the immunoglobulin lambda joining 1 and the immunoglobulin lambda constant 1 gene segments. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1complement activation, classical pathway (GO:0006958)8.64900430
2positive regulation of respiratory burst (GO:0060267)7.48911153
3complement activation (GO:0006956)6.85314118
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.23451999
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.16198590
6glomerular filtration (GO:0003094)5.99443955
7antigen processing and presentation of endogenous antigen (GO:0019883)5.86163618
8renal filtration (GO:0097205)5.37777413
9antimicrobial humoral response (GO:0019730)5.32000708
10antibacterial humoral response (GO:0019731)5.28059962
11regulation of cellular extravasation (GO:0002691)5.16592489
12regulation of respiratory burst (GO:0060263)5.15380073
13protein activation cascade (GO:0072376)5.01342593
14humoral immune response (GO:0006959)4.53736304
15regulation of dendritic cell antigen processing and presentation (GO:0002604)4.46104375
16angiotensin maturation (GO:0002003)4.31697921
17regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.22142450
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.05009925
19detection of bacterium (GO:0016045)4.01152564
20Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)4.00544589
21immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00024.00544589
22Fc-gamma receptor signaling pathway (GO:0038094)4.00544589
23Fc receptor mediated stimulatory signaling pathway (GO:0002431)3.98105199
24regulation of antigen processing and presentation (GO:0002577)3.95593283
25regulation of glucose import in response to insulin stimulus (GO:2001273)3.89051873
26positive regulation of antigen processing and presentation (GO:0002579)3.83360493
27detection of other organism (GO:0098543)3.79080922
28T cell migration (GO:0072678)3.77763421
29positive regulation of pseudopodium assembly (GO:0031274)3.73041013
30positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.68965503
31germinal center formation (GO:0002467)3.65984061
32immunoglobulin mediated immune response (GO:0016064)3.62936973
33positive regulation of Cdc42 GTPase activity (GO:0043089)3.53444995
34peptide catabolic process (GO:0043171)3.51654191
35regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.47261386
36interferon-gamma-mediated signaling pathway (GO:0060333)3.43046203
37virion attachment to host cell (GO:0019062)3.34311816
38adhesion of symbiont to host cell (GO:0044650)3.34311816
39NIK/NF-kappaB signaling (GO:0038061)3.33005929
40regulation of pseudopodium assembly (GO:0031272)3.31681397
41regulation of guanylate cyclase activity (GO:0031282)3.31487473
42response to type I interferon (GO:0034340)3.29253154
43cellular response to type I interferon (GO:0071357)3.29210728
44type I interferon signaling pathway (GO:0060337)3.29210728
45dendritic cell chemotaxis (GO:0002407)3.25403707
46GDP-mannose metabolic process (GO:0019673)3.24404865
47intestinal absorption (GO:0050892)3.13661916
48negative regulation of cell killing (GO:0031342)3.11817586
49negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.11817586
50apoptotic cell clearance (GO:0043277)3.04701356
51leukocyte tethering or rolling (GO:0050901)3.01485852
52immune response-activating cell surface receptor signaling pathway (GO:0002429)2.98415568
53multicellular organismal water homeostasis (GO:0050891)2.94126378
54B cell homeostasis (GO:0001782)2.93577650
55retina homeostasis (GO:0001895)2.91735242
56lymphocyte migration (GO:0072676)2.90638073
57maintenance of gastrointestinal epithelium (GO:0030277)2.87099818
58B cell receptor signaling pathway (GO:0050853)2.84506589
59cellular response to interferon-gamma (GO:0071346)2.81690534
60production of molecular mediator of immune response (GO:0002440)2.78758271
61positive regulation of T cell migration (GO:2000406)2.76265933
62NADH metabolic process (GO:0006734)2.76212608
63adhesion of symbiont to host (GO:0044406)2.75709638
64positive regulation of granulocyte chemotaxis (GO:0071624)2.75457015
65regulation of necrotic cell death (GO:0010939)2.75448972
66antigen processing and presentation via MHC class Ib (GO:0002475)2.74920304
67positive regulation of lymphocyte migration (GO:2000403)2.73257762
68B cell mediated immunity (GO:0019724)2.71068645
69phosphatidylserine acyl-chain remodeling (GO:0036150)2.69701800
70myeloid dendritic cell differentiation (GO:0043011)2.68654733
71response to interferon-gamma (GO:0034341)2.67668791
72eosinophil chemotaxis (GO:0048245)2.66989745
73T cell costimulation (GO:0031295)2.65558887
74regulation of T cell migration (GO:2000404)2.63230428
75detection of external biotic stimulus (GO:0098581)2.62316820
76lymphocyte costimulation (GO:0031294)2.61422349
77mannose metabolic process (GO:0006013)2.60785905
78renal system process involved in regulation of blood volume (GO:0001977)2.58352332
79defense response to Gram-negative bacterium (GO:0050829)2.56210185
80regulation of type I interferon-mediated signaling pathway (GO:0060338)2.53292530
81dendritic cell migration (GO:0036336)2.53221612
82N-acetylneuraminate metabolic process (GO:0006054)2.52904159
83positive regulation of neutrophil chemotaxis (GO:0090023)2.50871478
84positive regulation of neutrophil migration (GO:1902624)2.50871478
85regulation of vitamin metabolic process (GO:0030656)2.49857380
86regulation of viral release from host cell (GO:1902186)2.49005584
87T-helper cell differentiation (GO:0042093)2.48506762
88CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.48506762
89lymphocyte chemotaxis (GO:0048247)2.47780495
90myeloid dendritic cell activation (GO:0001773)2.47617107
91keratinization (GO:0031424)2.47488668
92chronic inflammatory response (GO:0002544)2.46165453
93regulation of integrin activation (GO:0033623)2.46077886
94regulation of lymphocyte migration (GO:2000401)2.44760204
95phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.43123942
96water homeostasis (GO:0030104)2.42699559
97positive regulation of gamma-delta T cell activation (GO:0046645)2.42591086
98immune response-activating signal transduction (GO:0002757)2.39029774
99mature B cell differentiation involved in immune response (GO:0002313)2.38616344
100eosinophil migration (GO:0072677)2.38174406

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.48106095
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.58780528
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.03970882
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.16785610
5E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.76237408
6MYC_22102868_ChIP-Seq_BL_Human2.69869870
7RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.67440256
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.64586260
9VDR_21846776_ChIP-Seq_THP-1_Human2.42002219
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.40122861
11LXR_22292898_ChIP-Seq_THP-1_Human2.27688110
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.25768380
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.11102050
14CDX2_20551321_ChIP-Seq_CACO-2_Human2.08733969
15VDR_24763502_ChIP-Seq_THP-1_Human2.07503087
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.06839977
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.06498099
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.04047209
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.01821629
20SOX2_27498859_Chip-Seq_STOMACH_Mouse1.93120500
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.90701893
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.90093257
23STAT4_19710469_ChIP-ChIP_TH1__Mouse1.86752146
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.82676887
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.80328686
26MYB_26560356_Chip-Seq_TH2_Human1.79748633
27ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.78543676
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.78140417
29MAF_26560356_Chip-Seq_TH1_Human1.76615732
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.76314636
31PPARA_22158963_ChIP-Seq_LIVER_Mouse1.75380226
32KDM2B_26808549_Chip-Seq_SUP-B15_Human1.71470584
33MYB_26560356_Chip-Seq_TH1_Human1.71115786
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.71027009
35UTX_26944678_Chip-Seq_JUKART_Human1.67126375
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.63878386
37RUNX_20019798_ChIP-Seq_JUKART_Human1.62888107
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.58952269
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.58740303
40TCF7_22412390_ChIP-Seq_EML_Mouse1.56939517
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.56327958
42BRD4_27068464_Chip-Seq_AML-cells_Mouse1.53090868
43FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.48200262
44RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.46828432
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.44245876
46RXR_22158963_ChIP-Seq_LIVER_Mouse1.44099207
47GATA2_22383799_ChIP-Seq_G1ME_Mouse1.43079032
48RACK7_27058665_Chip-Seq_MCF-7_Human1.42769731
49TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.40517188
50MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.37538121
51KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35617821
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.35296033
53BCL6_27268052_Chip-Seq_Bcells_Human1.33210470
54MYB_21317192_ChIP-Seq_ERMYB_Mouse1.33022962
55MAF_26560356_Chip-Seq_TH2_Human1.32109796
56CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31318730
57SPI1_23547873_ChIP-Seq_NB4_Human1.30472645
58GATA1_22383799_ChIP-Seq_G1ME_Mouse1.29872993
59CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29347881
60TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29076835
61BCOR_27268052_Chip-Seq_Bcells_Human1.28636078
62RARG_19884340_ChIP-ChIP_MEFs_Mouse1.27212848
63GATA6_25053715_ChIP-Seq_YYC3_Human1.26576194
64FOXO3_23340844_ChIP-Seq_DLD1_Human1.26316078
65ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.26117650
66PU.1_20513432_ChIP-Seq_Bcells_Mouse1.23163478
67P63_26484246_Chip-Seq_KERATINOCYTES_Human1.21912694
68SCL_19346495_ChIP-Seq_HPC-7_Human1.20455636
69KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.19452280
70PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18672713
71GATA4_25053715_ChIP-Seq_YYC3_Human1.17010752
72CLOCK_20551151_ChIP-Seq_293T_Human1.16820984
73LXR_22158963_ChIP-Seq_LIVER_Mouse1.15280960
74KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.15248557
75SPI1_23127762_ChIP-Seq_K562_Human1.14314093
76LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12801376
77GATA1_19941826_ChIP-Seq_K562_Human1.11778705
78DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11761517
79KDM2B_26808549_Chip-Seq_DND41_Human1.10283001
80BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10260591
81SOX2_20726797_ChIP-Seq_SW620_Human1.07939683
82SA1_27219007_Chip-Seq_ERYTHROID_Human1.07937053
83PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07850864
84TRIM28_21343339_ChIP-Seq_HEK293_Human1.07788612
85NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06917364
86BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.06291113
87EGR1_19032775_ChIP-ChIP_M12_Human1.04121545
88* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.03868615
89TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02820887
90PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.02418660
91CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.01909085
92GATA3_27048872_Chip-Seq_THYMUS_Human1.00972508
93SA1_27219007_Chip-Seq_Bcells_Human1.00069595
94NCOR1_26117541_ChIP-Seq_K562_Human0.99781332
95FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99260185
96CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99208753
97TET1_21451524_ChIP-Seq_MESCs_Mouse0.97925405
98GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97610076
99ETS1_21867929_ChIP-Seq_TH2_Mouse0.96210573
100TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95799060

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000685_abnormal_immune_system3.71800542
2MP0001835_abnormal_antigen_presentation3.67646560
3MP0010234_abnormal_vibrissa_follicle3.48197857
4MP0003303_peritoneal_inflammation3.42338173
5MP0010155_abnormal_intestine_physiology3.26632169
6MP0001790_abnormal_immune_system3.10201301
7MP0005387_immune_system_phenotype3.10201301
8MP0003724_increased_susceptibility_to2.77039883
9MP0003436_decreased_susceptibility_to2.67388908
10MP0004264_abnormal_extraembryonic_tissu2.61199327
11MP0005360_urolithiasis2.60882392
12MP0002139_abnormal_hepatobiliary_system2.52004882
13MP0001800_abnormal_humoral_immune2.48065561
14MP0005025_abnormal_response_to2.35075079
15MP0005671_abnormal_response_to2.30013487
16MP0002796_impaired_skin_barrier2.13650679
17MP0002138_abnormal_hepatobiliary_system2.08760461
18MP0009840_abnormal_foam_cell2.06035275
19MP0009785_altered_susceptibility_to2.05271727
20MP0002148_abnormal_hypersensitivity_rea2.05041074
21MP0001873_stomach_inflammation2.02816997
22MP0003866_abnormal_defecation2.01799765
23MP0004043_abnormal_pH_regulation2.01427640
24MP0005000_abnormal_immune_tolerance2.00165357
25MP0002452_abnormal_antigen_presenting1.96095805
26MP0003300_gastrointestinal_ulcer1.89652384
27MP0003763_abnormal_thymus_physiology1.89297318
28MP0009333_abnormal_splenocyte_physiolog1.88717503
29MP0000465_gastrointestinal_hemorrhage1.86612894
30MP0002723_abnormal_immune_serum1.86327900
31MP0001819_abnormal_immune_cell1.83863365
32MP0002420_abnormal_adaptive_immunity1.83065428
33MP0001666_abnormal_nutrient_absorption1.82385826
34MP0003183_abnormal_peptide_metabolism1.82273122
35MP0002166_altered_tumor_susceptibility1.80849355
36MP0004947_skin_inflammation1.79310413
37MP0001845_abnormal_inflammatory_respons1.78072291
38MP0004782_abnormal_surfactant_physiolog1.75034809
39MP0001663_abnormal_digestive_system1.74939485
40MP0005166_decreased_susceptibility_to1.72008519
41MP0010352_gastrointestinal_tract_polyps1.58535899
42MP0002933_joint_inflammation1.55525832
43MP0002419_abnormal_innate_immunity1.54872523
44MP0000490_abnormal_crypts_of1.52261713
45MP0005310_abnormal_salivary_gland1.51461766
46MP0000716_abnormal_immune_system1.46354439
47MP0005451_abnormal_body_composition1.46176469
48MP0001533_abnormal_skeleton_physiology1.45339869
49MP0009379_abnormal_foot_pigmentation1.40923461
50MP0002396_abnormal_hematopoietic_system1.39651708
51MP0008004_abnormal_stomach_pH1.36837278
52MP0005381_digestive/alimentary_phenotyp1.35675084
53MP0005085_abnormal_gallbladder_physiolo1.33467720
54MP0002398_abnormal_bone_marrow1.32217114
55MP0005275_abnormal_skin_tensile1.30396770
56MP0004858_abnormal_nervous_system1.30396415
57MP0003191_abnormal_cellular_cholesterol1.28055861
58MP0006082_CNS_inflammation1.21039636
59MP0002006_tumorigenesis1.20831736
60MP0000477_abnormal_intestine_morphology1.18898960
61MP0002429_abnormal_blood_cell1.15511911
62MP0003453_abnormal_keratinocyte_physiol1.14086455
63MP0009643_abnormal_urine_homeostasis1.13410016
64MP0005464_abnormal_platelet_physiology1.12069998
65MP0005409_darkened_coat_color1.04849923
66MP0001664_abnormal_digestion1.04658383
67MP0005501_abnormal_skin_physiology1.03246646
68MP0002722_abnormal_immune_system1.00118379
69MP0004019_abnormal_vitamin_homeostasis0.99853805
70MP0005058_abnormal_lysosome_morphology0.99375589
71MP0002405_respiratory_system_inflammati0.99028709
72MP0008469_abnormal_protein_level0.97410512
73MP0001765_abnormal_ion_homeostasis0.96951924
74MP0002098_abnormal_vibrissa_morphology0.96546086
75MP0002136_abnormal_kidney_physiology0.95918340
76MP0000689_abnormal_spleen_morphology0.94939018
77MP0005365_abnormal_bile_salt0.93832282
78MP0000858_altered_metastatic_potential0.92051974
79MP0009764_decreased_sensitivity_to0.90575830
80MP0003075_altered_response_to0.88196863
81MP0002998_abnormal_bone_remodeling0.87102752
82MP0005023_abnormal_wound_healing0.86327741
83MP0008260_abnormal_autophagy0.86323136
84MP0003448_altered_tumor_morphology0.85578285
85MP0003868_abnormal_feces_composition0.83434392
86MP0002876_abnormal_thyroid_physiology0.83185211
87MP0000604_amyloidosis0.82693319
88MP0001216_abnormal_epidermal_layer0.82613812
89MP0000343_altered_response_to0.78874225
90MP0000249_abnormal_blood_vessel0.77662380
91MP0000678_abnormal_parathyroid_gland0.77317528
92MP0003806_abnormal_nucleotide_metabolis0.75532590
93MP0002009_preneoplasia0.74000344
94MP0003045_fibrosis0.71765497
95MP0000681_abnormal_thyroid_gland0.68022791
96MP0009931_abnormal_skin_appearance0.67202312
97MP0003329_amyloid_beta_deposits0.62561806
98MP0001851_eye_inflammation0.61837149
99MP0004510_myositis0.60302310
100MP0005584_abnormal_enzyme/coenzyme_acti0.59673797

Predicted human phenotypes

RankGene SetZ-score
1Decreased circulating renin level (HP:0003351)5.87301310
2Hyperactive renin-angiotensin system (HP:0000841)5.77246777
3Systemic lupus erythematosus (HP:0002725)5.66365749
4Malnutrition (HP:0004395)5.08657006
5Eczematoid dermatitis (HP:0000976)4.01889803
6Gastrointestinal stroma tumor (HP:0100723)3.90191213
7Increased IgE level (HP:0003212)3.71222479
8Abnormality of glutamine family amino acid metabolism (HP:0010902)3.71169136
9Recurrent bronchitis (HP:0002837)3.62506305
10Premature loss of primary teeth (HP:0006323)3.54899631
11Abnormality of renin-angiotensin system (HP:0000847)3.48290199
12Abnormality of complement system (HP:0005339)3.44676068
13Chronic diarrhea (HP:0002028)3.34629219
14Glomerulonephritis (HP:0000099)3.34448311
15Abnormal delayed hypersensitivity skin test (HP:0002963)3.31280482
16Alkalosis (HP:0001948)3.31199508
17Vasculitis (HP:0002633)3.29241778
18Agammaglobulinemia (HP:0004432)3.25805381
19Complement deficiency (HP:0004431)3.20669378
20Emphysema (HP:0002097)3.16806819
21Colitis (HP:0002583)3.14310436
22Bronchitis (HP:0012387)3.12111496
23Meningitis (HP:0001287)3.06856491
24Nephritis (HP:0000123)3.04475416
25Urticaria (HP:0001025)3.03333345
26Abnormality of macrophages (HP:0004311)3.01580542
27Onycholysis (HP:0001806)2.88469474
28Inflammation of the large intestine (HP:0002037)2.86836856
29Abnormality of small intestinal villus morphology (HP:0011472)2.86818036
30Villous atrophy (HP:0011473)2.86818036
31Spontaneous hematomas (HP:0007420)2.86315165
32Hyperkalemia (HP:0002153)2.82320296
33IgM deficiency (HP:0002850)2.76761574
34Gastrointestinal inflammation (HP:0004386)2.76347588
35Recurrent bacterial skin infections (HP:0005406)2.73892538
36Abnormality of cells of the lymphoid lineage (HP:0012140)2.67023968
37Pustule (HP:0200039)2.66749438
38Cellulitis (HP:0100658)2.61933681
39Hypokalemic alkalosis (HP:0001949)2.59959360
40Abnormality of B cell number (HP:0010975)2.58270368
41Hyperaldosteronism (HP:0000859)2.57840824
42Abnormality of T cell physiology (HP:0011840)2.56345061
43Recurrent viral infections (HP:0004429)2.53516905
44Skin rash (HP:0000988)2.53334749
45Alopecia of scalp (HP:0002293)2.53059414
46Recurrent abscess formation (HP:0002722)2.51843683
47Abnormality of the nasal mucosa (HP:0000433)2.50938966
48Recurrent sinusitis (HP:0011108)2.50811113
49Chronic obstructive pulmonary disease (HP:0006510)2.47160889
50Obstructive lung disease (HP:0006536)2.47160889
51Chronic bronchitis (HP:0004469)2.38809957
52Abnormality of chloride homeostasis (HP:0011422)2.38068314
53Mediastinal lymphadenopathy (HP:0100721)2.37144801
54Abnormality of nail color (HP:0100643)2.35412864
55Gastrointestinal infarctions (HP:0005244)2.34978630
56Osteomyelitis (HP:0002754)2.34603913
57Chronic otitis media (HP:0000389)2.32671345
58Abnormality of monocarboxylic acid metabolism (HP:0010996)2.30166375
59Renal salt wasting (HP:0000127)2.27157016
60Right ventricular cardiomyopathy (HP:0011663)2.26885624
61Plantar hyperkeratosis (HP:0007556)2.24051514
62Hypergammaglobulinemia (HP:0010702)2.23665298
63Verrucae (HP:0200043)2.23644895
64Papilloma (HP:0012740)2.23644895
65Gingivitis (HP:0000230)2.22792616
66Ridged nail (HP:0001807)2.22076580
67Restrictive lung disease (HP:0002091)2.20982263
68Lymphopenia (HP:0001888)2.19924955
69Cone-rod dystrophy (HP:0000548)2.19809702
70IgA deficiency (HP:0002720)2.16721147
71Recurrent pneumonia (HP:0006532)2.16580711
72Hyponatremia (HP:0002902)2.15973991
73Nasal polyposis (HP:0100582)2.11847329
74Dehydration (HP:0001944)2.09969305
75Nuclear cataract (HP:0100018)2.09526708
76Ileus (HP:0002595)2.09056187
77Pulmonary infiltrates (HP:0002113)2.06109521
78Hypotension (HP:0002615)2.05053815
79Metabolic alkalosis (HP:0200114)2.04889867
80Hydroxyprolinuria (HP:0003080)2.04886027
81Abnormality of proline metabolism (HP:0010907)2.04886027
82Autoimmune thrombocytopenia (HP:0001973)2.04754171
83Recurrent fungal infections (HP:0002841)2.04190026
84Recurrent skin infections (HP:0001581)2.02114078
85Hemoptysis (HP:0002105)2.02012513
86Autoimmune hemolytic anemia (HP:0001890)2.00850280
87Recurrent lower respiratory tract infections (HP:0002783)2.00314278
88Hypokalemia (HP:0002900)2.00081228
89Recurrent gram-negative bacterial infections (HP:0005420)2.00041646
90Dry hair (HP:0011359)1.99271856
91Orchitis (HP:0100796)1.98537713
92Erythema (HP:0010783)1.98241448
93Abnormality of T cells (HP:0002843)1.97954227
94Myositis (HP:0100614)1.95191494
95Palmoplantar hyperkeratosis (HP:0000972)1.94458619
96Hemorrhage of the eye (HP:0011885)1.94095962
97Posterior subcapsular cataract (HP:0007787)1.93478344
98Encephalitis (HP:0002383)1.92682826
99Skin ulcer (HP:0200042)1.92388450
100Increased IgM level (HP:0003496)1.92266285

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN17.17121221
2PRPF4B3.80889467
3MAP4K13.66612778
4MAP3K103.29358101
5TAOK32.95040782
6TYK22.89159439
7MST1R2.48413032
8IKBKE2.12577974
9GRK62.08517988
10BLK2.05785904
11RIPK42.04926116
12FGFR41.98862315
13RIPK11.88417725
14ACVR1B1.84862170
15TBK11.74584479
16PKN21.69863361
17IRAK41.62148685
18STK241.58694386
19MAP3K141.40891029
20TRIB31.36321991
21CDC42BPA1.34115301
22JAK11.32708378
23JAK31.32039632
24MAP3K11.31238427
25FES1.27951584
26ZAP701.22673720
27SMG11.17739210
28SYK1.14470799
29PTK21.11001367
30EPHA31.09979823
31TESK21.08245553
32BTK1.07051880
33MAP3K131.05884577
34PRKG21.03617082
35ITK1.03536206
36FGFR31.02167372
37FLT31.01127282
38LYN1.01097101
39IKBKB1.00629420
40KIT1.00617994
41CSF1R0.98008492
42TXK0.97747563
43EPHB10.96507722
44CSK0.93134659
45MET0.92517148
46MAP2K20.90835294
47HCK0.88876619
48JAK20.88743225
49SIK10.88494829
50IRAK30.86267243
51TAOK10.84613625
52EPHA20.83363140
53MAPK70.83350083
54MAP3K110.79642889
55SIK30.78820721
56PIK3CA0.78532217
57IRAK10.76067871
58TNK20.72544484
59PRKD20.70844810
60MAPK110.67485169
61CDK190.65409503
62YES10.64980342
63PTK60.64619221
64KSR20.63144225
65PDPK10.62195177
66LCK0.61201171
67PDK10.60646383
68MATK0.59077466
69MAP2K30.57487030
70TEC0.57299588
71MARK20.56456378
72MAP2K60.55990291
73PIM10.55000203
74TGFBR20.54639645
75TESK10.54007430
76PIK3CG0.52235762
77HIPK20.52009549
78MAP3K30.51988022
79PDGFRA0.50540595
80BMX0.49920818
81PAK40.49155343
82EPHB20.46662862
83PRKCD0.46189074
84LRRK20.43700840
85DYRK1B0.43496600
86RET0.43320862
87LMTK20.42341415
88MAPKAPK20.41449622
89IRAK20.40952871
90NLK0.40745002
91MAPK40.40434024
92PRKCQ0.39945637
93DDR20.39834546
94MAPK120.38828580
95FYN0.36520144
96MAP3K20.35022062
97PDK20.33547298
98DMPK0.31278672
99CHUK0.30391869
100FGR0.29943201

Predicted pathways (KEGG)

RankGene SetZ-score
1Intestinal immune network for IgA production_Homo sapiens_hsa046724.39674103
2Cyanoamino acid metabolism_Homo sapiens_hsa004604.22786132
3Asthma_Homo sapiens_hsa053103.62839578
4Allograft rejection_Homo sapiens_hsa053303.44499940
5Staphylococcus aureus infection_Homo sapiens_hsa051503.32015150
6Autoimmune thyroid disease_Homo sapiens_hsa053203.28104300
7Graft-versus-host disease_Homo sapiens_hsa053323.16310199
8Type I diabetes mellitus_Homo sapiens_hsa049402.60185112
9Leishmaniasis_Homo sapiens_hsa051402.16036085
10Fat digestion and absorption_Homo sapiens_hsa049752.15835748
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.15624468
12Antigen processing and presentation_Homo sapiens_hsa046122.13765964
13Viral myocarditis_Homo sapiens_hsa054161.95342597
14Primary immunodeficiency_Homo sapiens_hsa053401.77681831
15Renin-angiotensin system_Homo sapiens_hsa046141.76995888
16Sulfur metabolism_Homo sapiens_hsa009201.71949644
17Arginine biosynthesis_Homo sapiens_hsa002201.67543033
18Fructose and mannose metabolism_Homo sapiens_hsa000511.45452300
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.44751639
20Toxoplasmosis_Homo sapiens_hsa051451.41552434
21Pertussis_Homo sapiens_hsa051331.33858147
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.30113821
23Influenza A_Homo sapiens_hsa051641.26081924
24Tuberculosis_Homo sapiens_hsa051521.25871435
25Vitamin digestion and absorption_Homo sapiens_hsa049771.25695222
26B cell receptor signaling pathway_Homo sapiens_hsa046621.25395039
27Other glycan degradation_Homo sapiens_hsa005111.24715744
28Rheumatoid arthritis_Homo sapiens_hsa053231.17316684
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.14986585
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.12691915
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.12227441
32Arachidonic acid metabolism_Homo sapiens_hsa005901.11023902
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.08509422
34Mineral absorption_Homo sapiens_hsa049781.07625249
35Herpes simplex infection_Homo sapiens_hsa051681.06151478
36Osteoclast differentiation_Homo sapiens_hsa043801.05234566
37Linoleic acid metabolism_Homo sapiens_hsa005911.04569704
38Hematopoietic cell lineage_Homo sapiens_hsa046401.04309000
39Histidine metabolism_Homo sapiens_hsa003400.99711763
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.93810703
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92780715
42Protein digestion and absorption_Homo sapiens_hsa049740.92422055
43Caffeine metabolism_Homo sapiens_hsa002320.91172978
44Chemokine signaling pathway_Homo sapiens_hsa040620.90550018
45Hepatitis C_Homo sapiens_hsa051600.84161801
46Toll-like receptor signaling pathway_Homo sapiens_hsa046200.80210720
47N-Glycan biosynthesis_Homo sapiens_hsa005100.79019997
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78018775
49Phagosome_Homo sapiens_hsa041450.75149094
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.74329125
51TNF signaling pathway_Homo sapiens_hsa046680.69456362
52Acute myeloid leukemia_Homo sapiens_hsa052210.66858888
53Measles_Homo sapiens_hsa051620.65212155
54Pancreatic secretion_Homo sapiens_hsa049720.64238422
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63400286
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62441796
57Glycerolipid metabolism_Homo sapiens_hsa005610.61760360
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60865130
59Complement and coagulation cascades_Homo sapiens_hsa046100.60856548
60Systemic lupus erythematosus_Homo sapiens_hsa053220.60700216
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60635604
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60132559
63Ether lipid metabolism_Homo sapiens_hsa005650.59589148
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55509855
65Leukocyte transendothelial migration_Homo sapiens_hsa046700.54942506
66Apoptosis_Homo sapiens_hsa042100.54045343
67Galactose metabolism_Homo sapiens_hsa000520.53842042
68Arginine and proline metabolism_Homo sapiens_hsa003300.53804828
69Starch and sucrose metabolism_Homo sapiens_hsa005000.52587192
70Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51940175
71Retinol metabolism_Homo sapiens_hsa008300.50027812
72PPAR signaling pathway_Homo sapiens_hsa033200.48725744
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46793053
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44389894
75Chemical carcinogenesis_Homo sapiens_hsa052040.43408630
76T cell receptor signaling pathway_Homo sapiens_hsa046600.41970408
77Jak-STAT signaling pathway_Homo sapiens_hsa046300.41027066
78Epstein-Barr virus infection_Homo sapiens_hsa051690.40705390
79Fatty acid degradation_Homo sapiens_hsa000710.40337601
80Hepatitis B_Homo sapiens_hsa051610.39279194
81African trypanosomiasis_Homo sapiens_hsa051430.39164205
82Bile secretion_Homo sapiens_hsa049760.39081787
83Lysosome_Homo sapiens_hsa041420.38510577
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.37998498
85Prion diseases_Homo sapiens_hsa050200.36835081
86HTLV-I infection_Homo sapiens_hsa051660.35761047
87Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35291930
88Glutathione metabolism_Homo sapiens_hsa004800.35231981
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34967679
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.34560086
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34337435
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.30755079
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30612908
94Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29507638
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28710898
962-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.27976684
97Malaria_Homo sapiens_hsa051440.25640258
98GnRH signaling pathway_Homo sapiens_hsa049120.25337318
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24851778
100Salmonella infection_Homo sapiens_hsa051320.23068162

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