IGLC6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1B cell receptor signaling pathway (GO:0050853)7.17406277
2regulation of B cell receptor signaling pathway (GO:0050855)5.72593015
3positive regulation of B cell differentiation (GO:0045579)5.70804515
4regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.48398622
5gonadal mesoderm development (GO:0007506)5.35395472
6B cell proliferation (GO:0042100)5.26465352
7immunoglobulin mediated immune response (GO:0016064)5.02169706
8production of molecular mediator involved in inflammatory response (GO:0002532)4.94933653
9B cell homeostasis (GO:0001782)4.94367288
10regulation of B cell differentiation (GO:0045577)4.92707888
11antigen processing and presentation of endogenous antigen (GO:0019883)4.89611663
12positive thymic T cell selection (GO:0045059)4.63583362
13positive regulation of gamma-delta T cell activation (GO:0046645)4.53259780
14CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.34885245
15* complement activation, classical pathway (GO:0006958)4.26992996
16negative regulation of B cell proliferation (GO:0030889)4.23410292
17regulation of antigen processing and presentation (GO:0002577)4.18215435
18antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.17099979
19defense response to protozoan (GO:0042832)4.17013133
20antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.14226232
21replicative senescence (GO:0090399)4.00393976
22detection of bacterium (GO:0016045)3.99430819
23regulation of B cell proliferation (GO:0030888)3.97927667
24positive regulation of respiratory burst (GO:0060267)3.93886302
25B cell mediated immunity (GO:0019724)3.93021657
26regulation of T-helper 1 cell differentiation (GO:0045625)3.85673456
27pyrimidine ribonucleoside catabolic process (GO:0046133)3.82163723
28positive regulation of CREB transcription factor activity (GO:0032793)3.79353710
29cytidine metabolic process (GO:0046087)3.76474024
30cytidine catabolic process (GO:0006216)3.76474024
31cytidine deamination (GO:0009972)3.76474024
32positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.76191523
33regulation of dendritic cell antigen processing and presentation (GO:0002604)3.66658174
34antigen receptor-mediated signaling pathway (GO:0050851)3.66157104
35detection of other organism (GO:0098543)3.65551953
36Peyers patch development (GO:0048541)3.65484718
37mucosal-associated lymphoid tissue development (GO:0048537)3.65484718
38* humoral immune response (GO:0006959)3.61688705
39positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.61465444
40DNA deamination (GO:0045006)3.60409025
41cellular hyperosmotic response (GO:0071474)3.58884760
42interferon-gamma-mediated signaling pathway (GO:0060333)3.58714467
43regulation of alpha-beta T cell proliferation (GO:0046640)3.55002009
44positive regulation of antigen processing and presentation (GO:0002579)3.54172814
45B cell activation (GO:0042113)3.52103668
46T cell lineage commitment (GO:0002360)3.51289471
47thymic T cell selection (GO:0045061)3.50234882
48negative regulation of T-helper cell differentiation (GO:0045623)3.48655337
49negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.48655337
50T cell selection (GO:0045058)3.47779129
51antigen processing and presentation via MHC class Ib (GO:0002475)3.47380158
52chaperone mediated protein folding requiring cofactor (GO:0051085)3.45632579
53regulation of fibroblast apoptotic process (GO:2000269)3.45528772
54positive regulation of B cell proliferation (GO:0030890)3.45356396
55antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.43971848
56positive regulation of protein homooligomerization (GO:0032464)3.42553719
57T cell costimulation (GO:0031295)3.42210630
58response to protozoan (GO:0001562)3.41760387
59lymphocyte costimulation (GO:0031294)3.37154616
60regulation of gamma-delta T cell differentiation (GO:0045586)3.36276775
61positive regulation of protein oligomerization (GO:0032461)3.33782630
62negative regulation of alpha-beta T cell activation (GO:0046636)3.31573449
63positive regulation of B cell activation (GO:0050871)3.30879770
64regulation of germinal center formation (GO:0002634)3.30455091
65* immune response-activating cell surface receptor signaling pathway (GO:0002429)3.29785534
66positive T cell selection (GO:0043368)3.28129398
67antibacterial humoral response (GO:0019731)3.24924355
68positive regulation of type 2 immune response (GO:0002830)3.18158442
69antimicrobial humoral response (GO:0019730)3.16860795
70negative regulation of calcium ion transport into cytosol (GO:0010523)3.15161893
71* complement activation (GO:0006956)3.14624172
72regulation of respiratory burst (GO:0060263)3.13015105
73negative regulation of phagocytosis (GO:0050765)3.11314383
74regulation of gamma-delta T cell activation (GO:0046643)3.06234258
75dendritic cell migration (GO:0036336)3.05259088
76T cell migration (GO:0072678)3.02888448
77cellular response to type I interferon (GO:0071357)3.01023944
78type I interferon signaling pathway (GO:0060337)3.01023944
79dendritic cell chemotaxis (GO:0002407)3.00447605
80negative thymic T cell selection (GO:0045060)2.99992844
81response to type I interferon (GO:0034340)2.99213652
82regulation of Golgi to plasma membrane protein transport (GO:0042996)2.98491846
83regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.98348143
84positive regulation of chemokine secretion (GO:0090197)2.96229071
85lymphocyte homeostasis (GO:0002260)2.96116006
86cellular response to virus (GO:0098586)2.95890582
87regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.91757198
88positive regulation of interferon-alpha production (GO:0032727)2.88079156
89natural killer cell differentiation (GO:0001779)2.87419289
90negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.86602420
91positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.85724220
92regulation of B cell activation (GO:0050864)2.85469241
93regulation of alpha-beta T cell activation (GO:0046634)2.85079142
94positive regulation of alpha-beta T cell differentiation (GO:0046638)2.84560271
95leukocyte homeostasis (GO:0001776)2.83697761
96regulation of interferon-beta biosynthetic process (GO:0045357)2.83482644
97NIK/NF-kappaB signaling (GO:0038061)2.78842300
98negative T cell selection (GO:0043383)2.76802781
99regulation of alpha-beta T cell differentiation (GO:0046637)2.75835987
100regulation of interferon-gamma biosynthetic process (GO:0045072)2.73233424

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human8.98125776
2MYC_22102868_ChIP-Seq_BL_Human5.02300335
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.86478240
4E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human3.76179281
5SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.63506526
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.47006076
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.28634454
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.18659943
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.14858285
10CIITA_25753668_ChIP-Seq_RAJI_Human2.92037292
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.89940228
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.59004461
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.57576586
14MYB_26560356_Chip-Seq_TH2_Human2.43513294
15E2F7_22180533_ChIP-Seq_HELA_Human2.41504234
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.35537778
17VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.32845192
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.31721048
19EZH2_22144423_ChIP-Seq_EOC_Human2.27974844
20MYB_26560356_Chip-Seq_TH1_Human2.09360049
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.05411274
22SPI1_23547873_ChIP-Seq_NB4_Human2.04140504
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.03032430
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.95898443
25RUNX_20019798_ChIP-Seq_JUKART_Human1.87764649
26VDR_21846776_ChIP-Seq_THP-1_Human1.86234739
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.78858594
28SCL_19346495_ChIP-Seq_HPC-7_Human1.74297642
29MAF_26560356_Chip-Seq_TH1_Human1.70530152
30VDR_24763502_ChIP-Seq_THP-1_Human1.63066499
31GATA3_26560356_Chip-Seq_TH2_Human1.54369070
32FOXP3_21729870_ChIP-Seq_TREG_Human1.53585609
33UTX_26944678_Chip-Seq_JUKART_Human1.52206796
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48953214
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.48855690
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.46802155
37MAF_26560356_Chip-Seq_TH2_Human1.44557515
38PU.1_20513432_ChIP-Seq_Bcells_Mouse1.44299984
39STAT4_19710469_ChIP-ChIP_TH1__Mouse1.42122617
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41461191
41BP1_19119308_ChIP-ChIP_Hs578T_Human1.41158501
42NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37946927
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.34600016
44NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.32856094
45SMRT_27268052_Chip-Seq_Bcells_Human1.28465883
46GATA3_27048872_Chip-Seq_THYMUS_Human1.27939644
47E2F4_17652178_ChIP-ChIP_JURKAT_Human1.27191312
48BCL6_27268052_Chip-Seq_Bcells_Human1.26050431
49STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.24994029
50MYB_21317192_ChIP-Seq_ERMYB_Mouse1.22235523
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21411053
52P300_27268052_Chip-Seq_Bcells_Human1.19076946
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.18520482
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17704995
55EST1_17652178_ChIP-ChIP_JURKAT_Human1.17251004
56CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16358613
57MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.15338165
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15255882
59GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14572700
60VDR_23849224_ChIP-Seq_CD4+_Human1.13650483
61EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.07429526
62HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07111271
63NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.06977714
64SPI1_23127762_ChIP-Seq_K562_Human1.05298323
65BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04486042
66BCOR_27268052_Chip-Seq_Bcells_Human1.02837266
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02816721
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02483237
69KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00750333
70FOXM1_23109430_ChIP-Seq_U2OS_Human0.98691845
71LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.98513078
72GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98382944
73E2F1_20622854_ChIP-Seq_HELA_Human0.96779448
74CTCF_26484167_Chip-Seq_Bcells_Mouse0.95506661
75TCF7_22412390_ChIP-Seq_EML_Mouse0.92760594
76VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.90577953
77FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87066610
78EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.87054979
79EGR1_23403033_ChIP-Seq_LIVER_Mouse0.86774663
80VDR_24787735_ChIP-Seq_THP-1_Human0.84799449
81STAT1_20625510_ChIP-Seq_HELA_Human0.84670170
82ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84255808
83GATA1_22383799_ChIP-Seq_G1ME_Mouse0.83798538
84SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82583948
85SPI1_20517297_ChIP-Seq_HL60_Human0.79580068
86GATA3_26560356_Chip-Seq_TH1_Human0.79265991
87CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79016813
88PU_27001747_Chip-Seq_BMDM_Mouse0.78287311
89PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.77733391
90PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77585877
91ETS1_20019798_ChIP-Seq_JURKAT_Human0.77127401
92LXR_22292898_ChIP-Seq_THP-1_Human0.76721119
93FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76096553
94CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.75862353
95KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.75110432
96KDM5A_27292631_Chip-Seq_BREAST_Human0.75084568
97ELF1_20517297_ChIP-Seq_JURKAT_Human0.74245273
98GATA1_19941827_ChIP-Seq_MEL_Mouse0.73377101
99CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73114467
100JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.72959626

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.07524671
2MP0001790_abnormal_immune_system4.36541403
3MP0005387_immune_system_phenotype4.36541403
4MP0001800_abnormal_humoral_immune4.22259632
5MP0002138_abnormal_hepatobiliary_system3.90370857
6MP0000685_abnormal_immune_system3.79404850
7MP0005671_abnormal_response_to3.38099543
8MP0002452_abnormal_antigen_presenting3.20632109
9MP0003303_peritoneal_inflammation3.14150386
10MP0003763_abnormal_thymus_physiology3.02113756
11MP0005000_abnormal_immune_tolerance2.91810385
12MP0002723_abnormal_immune_serum2.85859193
13MP0002420_abnormal_adaptive_immunity2.75892621
14MP0001819_abnormal_immune_cell2.69895454
15MP0002166_altered_tumor_susceptibility2.53414783
16MP0002398_abnormal_bone_marrow2.52908639
17MP0000465_gastrointestinal_hemorrhage2.47070324
18MP0000716_abnormal_immune_system2.34824639
19MP0002148_abnormal_hypersensitivity_rea2.23905174
20MP0000689_abnormal_spleen_morphology2.13969411
21MP0002396_abnormal_hematopoietic_system2.12735200
22MP0005025_abnormal_response_to2.04224974
23MP0010155_abnormal_intestine_physiology2.01646638
24MP0002429_abnormal_blood_cell1.91769162
25MP0001873_stomach_inflammation1.86306706
26MP0009785_altered_susceptibility_to1.79714540
27MP0002006_tumorigenesis1.74434178
28MP0005310_abnormal_salivary_gland1.74412089
29MP0003045_fibrosis1.69941896
30MP0002722_abnormal_immune_system1.68200428
31MP0003436_decreased_susceptibility_to1.65733050
32MP0001845_abnormal_inflammatory_respons1.59663912
33MP0002419_abnormal_innate_immunity1.54542182
34MP0003183_abnormal_peptide_metabolism1.51964979
35MP0009333_abnormal_splenocyte_physiolog1.51119252
36MP0002405_respiratory_system_inflammati1.49759569
37MP0003172_abnormal_lysosome_physiology1.44621326
38MP0000490_abnormal_crypts_of1.42368369
39MP0005360_urolithiasis1.40941224
40MP0002139_abnormal_hepatobiliary_system1.40604858
41MP0010234_abnormal_vibrissa_follicle1.40187562
42MP0001348_abnormal_lacrimal_gland1.39252265
43MP0000703_abnormal_thymus_morphology1.34854224
44MP0001986_abnormal_taste_sensitivity1.32742263
45MP0010094_abnormal_chromosome_stability1.31632800
46MP0003724_increased_susceptibility_to1.27225665
47MP0009278_abnormal_bone_marrow1.24907076
48MP0001663_abnormal_digestive_system1.19876678
49MP0003866_abnormal_defecation1.19150606
50MP0005075_abnormal_melanosome_morpholog1.15942134
51MP0002019_abnormal_tumor_incidence1.12698278
52MP0005464_abnormal_platelet_physiology1.10746407
53MP0002009_preneoplasia1.10455962
54MP0002163_abnormal_gland_morphology1.08246114
55MP0002136_abnormal_kidney_physiology1.05248304
56MP0004808_abnormal_hematopoietic_stem1.02931591
57MP0004947_skin_inflammation1.02137421
58MP0001853_heart_inflammation0.99354125
59MP0005451_abnormal_body_composition0.98976847
60MP0003693_abnormal_embryo_hatching0.98054013
61MP0006036_abnormal_mitochondrial_physio0.91439541
62MP0002796_impaired_skin_barrier0.90075933
63MP0008004_abnormal_stomach_pH0.89104770
64MP0008877_abnormal_DNA_methylation0.87325059
65MP0008469_abnormal_protein_level0.85904701
66MP0005381_digestive/alimentary_phenotyp0.84970005
67MP0003077_abnormal_cell_cycle0.84783603
68MP0003111_abnormal_nucleus_morphology0.84772283
69MP0002928_abnormal_bile_duct0.84714430
70MP0005501_abnormal_skin_physiology0.83817484
71MP0001764_abnormal_homeostasis0.80284914
72MP0001661_extended_life_span0.79327075
73MP0003786_premature_aging0.76204197
74MP0008874_decreased_physiological_sensi0.75026891
75MP0004381_abnormal_hair_follicle0.74560287
76MP0004264_abnormal_extraembryonic_tissu0.74393878
77MP0003806_abnormal_nucleotide_metabolis0.73625401
78MP0009643_abnormal_urine_homeostasis0.72941844
79MP0005085_abnormal_gallbladder_physiolo0.69910059
80MP0005379_endocrine/exocrine_gland_phen0.69348062
81MP0000372_irregular_coat_pigmentation0.69291679
82MP0001666_abnormal_nutrient_absorption0.68790408
83MP0003300_gastrointestinal_ulcer0.68185553
84MP0000371_diluted_coat_color0.64494296
85MP0003868_abnormal_feces_composition0.62917235
86MP0000249_abnormal_blood_vessel0.62457841
87MP0004145_abnormal_muscle_electrophysio0.61433238
88MP0002693_abnormal_pancreas_physiology0.61100147
89MP0004883_abnormal_blood_vessel0.59580655
90MP0003252_abnormal_bile_duct0.58701552
91MP0001765_abnormal_ion_homeostasis0.58440694
92MP0005084_abnormal_gallbladder_morpholo0.58137169
93MP0008057_abnormal_DNA_replication0.57567813
94MP0000015_abnormal_ear_pigmentation0.54424983
95MP0005645_abnormal_hypothalamus_physiol0.54396340
96MP0003646_muscle_fatigue0.53809037
97MP0000477_abnormal_intestine_morphology0.51124058
98MP0009764_decreased_sensitivity_to0.50805425
99MP0001533_abnormal_skeleton_physiology0.49979379
100MP0008872_abnormal_physiological_respon0.49155512

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)9.38318712
2Gastrointestinal stroma tumor (HP:0100723)8.38584495
3Recurrent sinusitis (HP:0011108)6.17326796
4Verrucae (HP:0200043)5.86161416
5Papilloma (HP:0012740)5.86161416
6Recurrent bronchitis (HP:0002837)5.58217397
7Cellulitis (HP:0100658)5.33893782
8Meningitis (HP:0001287)5.12288932
9Lymphopenia (HP:0001888)5.04301106
10Panhypogammaglobulinemia (HP:0003139)4.83469718
11Abnormality of cells of the lymphoid lineage (HP:0012140)4.62006039
12Emphysema (HP:0002097)4.56071276
13Vasculitis (HP:0002633)4.50636072
14Abnormality of B cell number (HP:0010975)4.43224855
15Colitis (HP:0002583)4.40722381
16Recurrent pneumonia (HP:0006532)4.40020755
17Osteomyelitis (HP:0002754)4.34575884
18B lymphocytopenia (HP:0010976)4.34039570
19Recurrent viral infections (HP:0004429)4.14202122
20IgM deficiency (HP:0002850)4.07982970
21IgG deficiency (HP:0004315)3.89970416
22Abnormal delayed hypersensitivity skin test (HP:0002963)3.86437604
23Chronic sinusitis (HP:0011109)3.71565480
24Restrictive lung disease (HP:0002091)3.71199835
25Recurrent lower respiratory tract infections (HP:0002783)3.68022513
26Sepsis (HP:0100806)3.53241815
27Bronchitis (HP:0012387)3.50873137
28Recurrent otitis media (HP:0000403)3.41112362
29Inflammation of the large intestine (HP:0002037)3.36039235
30Gastrointestinal inflammation (HP:0004386)3.24910605
31Mediastinal lymphadenopathy (HP:0100721)3.19709040
32Lymphoma (HP:0002665)3.13398647
33Skin rash (HP:0000988)3.12907835
34Recurrent fungal infections (HP:0002841)2.96645557
35Recurrent bacterial skin infections (HP:0005406)2.90267841
36IgA deficiency (HP:0002720)2.83367440
37Neutropenia (HP:0001875)2.68376535
38Leukopenia (HP:0001882)2.63093417
39Abnormality of the prostate (HP:0008775)2.61132420
40Stomatitis (HP:0010280)2.58730669
41Abnormality of T cell physiology (HP:0011840)2.53225918
42Abnormal biliary tract physiology (HP:0012439)2.43557937
43Bile duct proliferation (HP:0001408)2.43557937
44Dehydration (HP:0001944)2.37127272
45Recurrent abscess formation (HP:0002722)2.31312301
46Hypoplasia of the thymus (HP:0000778)2.31184407
47Viral hepatitis (HP:0006562)2.31048954
48Elevated erythrocyte sedimentation rate (HP:0003565)2.29407712
49Malnutrition (HP:0004395)2.23359997
50Abnormality of T cells (HP:0002843)2.20933024
51Pulmonary infiltrates (HP:0002113)2.20092463
52Chronic obstructive pulmonary disease (HP:0006510)2.19361298
53Obstructive lung disease (HP:0006536)2.19361298
54Chronic mucocutaneous candidiasis (HP:0002728)2.18761582
55Recurrent cutaneous fungal infections (HP:0011370)2.18761582
56Eczematoid dermatitis (HP:0000976)2.17805824
57Facial hemangioma (HP:0000329)2.17607045
58Recurrent skin infections (HP:0001581)2.14651770
59Chronic otitis media (HP:0000389)2.12500915
60Decreased circulating renin level (HP:0003351)2.09037942
61Encephalitis (HP:0002383)2.06852313
62Abnormality of the fingertips (HP:0001211)2.06385231
63Skin ulcer (HP:0200042)2.02979400
64Clubbing of toes (HP:0100760)2.02601637
65Urticaria (HP:0001025)2.01868845
66Premature loss of primary teeth (HP:0006323)1.99589804
67Increased IgE level (HP:0003212)1.95434515
68Pustule (HP:0200039)1.94158734
69Homocystinuria (HP:0002156)1.90870248
70Abnormality of homocysteine metabolism (HP:0010919)1.90870248
71Asplenia (HP:0001746)1.87182219
723-Methylglutaconic aciduria (HP:0003535)1.83546274
73Arthralgia (HP:0002829)1.79730676
74Chest pain (HP:0100749)1.77811576
75Prostate neoplasm (HP:0100787)1.77796613
76Congenital stationary night blindness (HP:0007642)1.77510303
77Elevated hepatic transaminases (HP:0002910)1.75274908
78Acrocyanosis (HP:0001063)1.75081932
79Aplasia/Hypoplasia of the spleen (HP:0010451)1.73086254
80Eosinophilia (HP:0001880)1.72061261
81Parakeratosis (HP:0001036)1.69349028
82Hyperactive renin-angiotensin system (HP:0000841)1.68528021
83Chronic diarrhea (HP:0002028)1.66616796
84Hypertensive crisis (HP:0100735)1.66012532
85Basal cell carcinoma (HP:0002671)1.63273039
86Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.62459504
87Abnormality of male internal genitalia (HP:0000022)1.61534107
88Gastrointestinal infarctions (HP:0005244)1.60730435
89Hypoproteinemia (HP:0003075)1.60712287
90Pulmonary fibrosis (HP:0002206)1.60045527
91Dicarboxylic aciduria (HP:0003215)1.58732011
92Abnormality of dicarboxylic acid metabolism (HP:0010995)1.58732011
93Abnormality of the pleura (HP:0002103)1.58196355
94Aplasia/Hypoplasia of the thymus (HP:0010515)1.57729230
95Xerostomia (HP:0000217)1.54752737
96Thoracic kyphosis (HP:0002942)1.52561519
97Paralysis (HP:0003470)1.52129258
98Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.52007738
99Albinism (HP:0001022)1.50788415
100Abnormality of T cell number (HP:0011839)1.50094912

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K105.49979433
2RIPK45.27506456
3MAP4K14.42481912
4BMPR23.61283856
5PRPF4B3.42773383
6ERN13.35092374
7TAOK33.23260124
8BLK3.18129865
9SMG12.65788740
10SYK2.53825593
11EIF2AK32.50502646
12VRK22.41958549
13BTK2.33057399
14GRK62.28461669
15EIF2AK12.12631126
16CDK191.46350875
17TYK21.43686158
18LYN1.42524771
19TAF11.40356602
20IRAK41.38036984
21PIK3CG1.37261409
22CSF1R1.33251976
23NEK91.31337643
24FES1.26083107
25PRKD21.18333886
26IKBKB1.15743496
27TAOK21.13155782
28GRK11.11069675
29IRAK31.10317921
30MST41.05723403
31CDK41.05598938
32SIK21.04876570
33MAPK111.01487474
34MELK1.01257639
35SIK30.98190663
36PRKCI0.89681409
37IRAK20.88316285
38CDK90.86945638
39CDK80.86915504
40CCNB10.86011972
41PIM10.82262562
42CSK0.81662515
43ITK0.81252157
44TEC0.80426431
45HCK0.78596221
46HIPK20.76612278
47PINK10.73315113
48JAK30.68208220
49TBK10.65773819
50PRKCQ0.63087140
51MARK20.61534700
52TNK20.61252487
53STK110.61107585
54OXSR10.59731338
55IKBKE0.56120728
56LRRK20.56088962
57LCK0.53228874
58BUB10.51841286
59VRK10.50705508
60EIF2AK20.46589473
61IRAK10.46393863
62STK390.45500621
63MAPK40.45097603
64MAPKAPK20.44959477
65STK100.43501645
66MAPK120.43394269
67STK240.41942475
68MAP2K20.41707586
69ATR0.40539821
70MAPK70.40433021
71EEF2K0.39936889
72MAP3K140.39579245
73MAP3K10.38864978
74CDK30.34768951
75PRKD10.34240982
76PDK10.33409584
77STK40.33329786
78TAOK10.33115124
79MAPKAPK50.32621949
80CHUK0.31396223
81PIM20.28731217
82DAPK10.28619498
83CHEK10.27472343
84PDPK10.26649256
85MAP3K130.25920564
86KIT0.25718656
87DYRK1B0.25404624
88ABL10.25310373
89MAPK90.24415340
90RPS6KB10.23946217
91PRKCD0.23708409
92CDC42BPA0.22764037
93CDK60.22267199
94AURKB0.20811546
95JAK10.20533888
96ZAP700.20452735
97MAP3K80.19788440
98INSR0.18509384
99MAP2K30.17612668
100PRKCZ0.17261712

Predicted pathways (KEGG)

RankGene SetZ-score
1Intestinal immune network for IgA production_Homo sapiens_hsa046725.61458696
2Asthma_Homo sapiens_hsa053104.96238511
3Primary immunodeficiency_Homo sapiens_hsa053404.70912117
4Allograft rejection_Homo sapiens_hsa053304.40190602
5Autoimmune thyroid disease_Homo sapiens_hsa053204.18278631
6Graft-versus-host disease_Homo sapiens_hsa053324.01678984
7B cell receptor signaling pathway_Homo sapiens_hsa046623.46697527
8Type I diabetes mellitus_Homo sapiens_hsa049403.37461514
9Staphylococcus aureus infection_Homo sapiens_hsa051502.73365089
10Antigen processing and presentation_Homo sapiens_hsa046122.68859872
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.61256516
12Viral myocarditis_Homo sapiens_hsa054162.58666957
13Leishmaniasis_Homo sapiens_hsa051402.27080107
14Cyanoamino acid metabolism_Homo sapiens_hsa004602.22272084
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.89625094
16Hematopoietic cell lineage_Homo sapiens_hsa046401.70214035
17Herpes simplex infection_Homo sapiens_hsa051681.54161219
18DNA replication_Homo sapiens_hsa030301.53041346
19Rheumatoid arthritis_Homo sapiens_hsa053231.35270180
20Influenza A_Homo sapiens_hsa051641.30242814
21Tuberculosis_Homo sapiens_hsa051521.23204258
22Toxoplasmosis_Homo sapiens_hsa051451.20910700
23Non-homologous end-joining_Homo sapiens_hsa034501.20690639
24Epstein-Barr virus infection_Homo sapiens_hsa051691.18784651
25Mismatch repair_Homo sapiens_hsa034301.12144876
26Proteasome_Homo sapiens_hsa030501.00521388
27HTLV-I infection_Homo sapiens_hsa051661.00174720
28One carbon pool by folate_Homo sapiens_hsa006700.97494491
29Homologous recombination_Homo sapiens_hsa034400.96577298
30Osteoclast differentiation_Homo sapiens_hsa043800.91868405
31Base excision repair_Homo sapiens_hsa034100.91534032
32Vitamin B6 metabolism_Homo sapiens_hsa007500.77271892
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72529722
34Hepatitis B_Homo sapiens_hsa051610.68012402
35Measles_Homo sapiens_hsa051620.67510355
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67198670
37T cell receptor signaling pathway_Homo sapiens_hsa046600.65598876
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61594423
39Caffeine metabolism_Homo sapiens_hsa002320.60356924
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58966949
41Systemic lupus erythematosus_Homo sapiens_hsa053220.57827633
42RNA degradation_Homo sapiens_hsa030180.56700317
43Apoptosis_Homo sapiens_hsa042100.55873440
44Phagosome_Homo sapiens_hsa041450.55036537
45Other glycan degradation_Homo sapiens_hsa005110.53244722
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51674857
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49975120
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48938472
49Fat digestion and absorption_Homo sapiens_hsa049750.47766660
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46659340
51N-Glycan biosynthesis_Homo sapiens_hsa005100.45141222
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.44898767
53Jak-STAT signaling pathway_Homo sapiens_hsa046300.44247105
54Linoleic acid metabolism_Homo sapiens_hsa005910.43857159
55Vitamin digestion and absorption_Homo sapiens_hsa049770.41556841
56Chemokine signaling pathway_Homo sapiens_hsa040620.40814420
57Nucleotide excision repair_Homo sapiens_hsa034200.40160679
58Non-small cell lung cancer_Homo sapiens_hsa052230.39119437
59Ether lipid metabolism_Homo sapiens_hsa005650.39021934
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38451165
61Ribosome_Homo sapiens_hsa030100.35853343
62Pentose phosphate pathway_Homo sapiens_hsa000300.35177418
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34558336
64Toll-like receptor signaling pathway_Homo sapiens_hsa046200.33859770
65Viral carcinogenesis_Homo sapiens_hsa052030.31108376
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30098090
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.24674848
68Arachidonic acid metabolism_Homo sapiens_hsa005900.24640441
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.24528477
70Hepatitis C_Homo sapiens_hsa051600.23856257
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22636199
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.21556707
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.21088715
74Protein export_Homo sapiens_hsa030600.20572632
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.18526002
76Spliceosome_Homo sapiens_hsa030400.18213367
77Arginine biosynthesis_Homo sapiens_hsa002200.16607154
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.16553981
79Fanconi anemia pathway_Homo sapiens_hsa034600.15592637
80TNF signaling pathway_Homo sapiens_hsa046680.15586856
81Pyrimidine metabolism_Homo sapiens_hsa002400.14931146
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.14470974
83Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.14221819
84Phototransduction_Homo sapiens_hsa047440.12875225
85African trypanosomiasis_Homo sapiens_hsa051430.11515671
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.10660754
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.10564486
88Cell cycle_Homo sapiens_hsa041100.10142982
89Acute myeloid leukemia_Homo sapiens_hsa052210.09856611
90Small cell lung cancer_Homo sapiens_hsa052220.09513422
91Sulfur metabolism_Homo sapiens_hsa009200.07822084
92Platelet activation_Homo sapiens_hsa046110.07323076
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.07308633
94Pertussis_Homo sapiens_hsa051330.06245259
95ABC transporters_Homo sapiens_hsa020100.05252992
96Carbon metabolism_Homo sapiens_hsa012000.05199176
97mRNA surveillance pathway_Homo sapiens_hsa030150.04531446
98FoxO signaling pathway_Homo sapiens_hsa040680.02937618
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.01708845
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0019346

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