IGKV3-11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1humoral immune response (GO:0006959)9.27390776
2positive regulation of respiratory burst (GO:0060267)8.24715474
3glomerular filtration (GO:0003094)7.23148076
4renal filtration (GO:0097205)6.55028934
5signal peptide processing (GO:0006465)5.97943857
6immune response-activating cell surface receptor signaling pathway (GO:0002429)5.96883651
7negative regulation of glucose import (GO:0046325)5.49902732
8regulation of respiratory burst (GO:0060263)5.42855940
9regulation of glucose import in response to insulin stimulus (GO:2001273)5.12515637
10antimicrobial humoral response (GO:0019730)5.10932953
11Fc-epsilon receptor signaling pathway (GO:0038095)4.94288210
12phenylpropanoid metabolic process (GO:0009698)4.82266172
13Fc receptor signaling pathway (GO:0038093)4.79690018
14B cell receptor signaling pathway (GO:0050853)4.52930053
15regulation of cellular extravasation (GO:0002691)4.52065284
16negative regulation of glucose transport (GO:0010829)4.44346321
17regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)4.40882022
18negative regulation of B cell proliferation (GO:0030889)4.25901194
19immune response-regulating cell surface receptor signaling pathway (GO:0002768)4.23319467
20cellular response to zinc ion (GO:0071294)3.91117843
21immunoglobulin mediated immune response (GO:0016064)3.86349849
22regulation of dendritic cell antigen processing and presentation (GO:0002604)3.82916847
23detection of bacterium (GO:0016045)3.81621199
24interferon-gamma-mediated signaling pathway (GO:0060333)3.74452085
25detection of other organism (GO:0098543)3.73944093
26immune response-activating signal transduction (GO:0002757)3.73100148
27regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.58396967
28negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.51747539
29negative regulation of cell killing (GO:0031342)3.51747539
30regulation of B cell proliferation (GO:0030888)3.50861706
31antigen processing and presentation of endogenous antigen (GO:0019883)3.48861010
32regulation of antigen processing and presentation (GO:0002577)3.47938479
33germinal center formation (GO:0002467)3.45333352
34activation of immune response (GO:0002253)3.40420785
35angiotensin maturation (GO:0002003)3.39303420
36cellular response to type I interferon (GO:0071357)3.38331051
37type I interferon signaling pathway (GO:0060337)3.38331051
38response to type I interferon (GO:0034340)3.36359412
39polyketide metabolic process (GO:0030638)3.27131652
40doxorubicin metabolic process (GO:0044598)3.27131652
41daunorubicin metabolic process (GO:0044597)3.27131652
42positive regulation of macrophage cytokine production (GO:0060907)3.24721964
43positive regulation of antigen processing and presentation (GO:0002579)3.22860849
44positive regulation of gamma-delta T cell activation (GO:0046645)3.21967006
45regulation of B cell differentiation (GO:0045577)3.21528911
46positive regulation of B cell differentiation (GO:0045579)3.18946017
47antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.18775468
48negative regulation of myotube differentiation (GO:0010832)3.14932779
49fucose catabolic process (GO:0019317)3.14697707
50L-fucose metabolic process (GO:0042354)3.14697707
51L-fucose catabolic process (GO:0042355)3.14697707
52positive regulation of pseudopodium assembly (GO:0031274)3.10444684
53cellular response to interferon-gamma (GO:0071346)3.02825371
54regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.01320875
55complement activation, classical pathway (GO:0006958)27.8863402
56complement activation (GO:0006956)21.3886697
57positive regulation of Cdc42 GTPase activity (GO:0043089)2.96421696
58surfactant homeostasis (GO:0043129)2.94274104
59chronic inflammatory response (GO:0002544)2.91797571
60maintenance of gastrointestinal epithelium (GO:0030277)2.90939039
61B cell mediated immunity (GO:0019724)2.89477673
62NIK/NF-kappaB signaling (GO:0038061)2.87346840
63T-helper 1 type immune response (GO:0042088)2.84095063
64response to interferon-gamma (GO:0034341)2.82477253
65peptide catabolic process (GO:0043171)2.82074596
66detection of external biotic stimulus (GO:0098581)2.81924898
67production of molecular mediator of immune response (GO:0002440)2.81660948
68negative regulation of cellular response to insulin stimulus (GO:1900077)2.80527718
69xenobiotic catabolic process (GO:0042178)2.79912697
70positive regulation of immunoglobulin production (GO:0002639)2.79662033
71antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.78685708
72antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.78685708
73cofactor catabolic process (GO:0051187)2.78006788
74proline biosynthetic process (GO:0006561)2.77799896
75mast cell activation (GO:0045576)2.76043874
76regulation of pseudopodium assembly (GO:0031272)2.75522441
77regulation of integrin activation (GO:0033623)2.73540902
78positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.72806986
79dendritic cell chemotaxis (GO:0002407)2.71706019
80adhesion of symbiont to host cell (GO:0044650)2.69640024
81virion attachment to host cell (GO:0019062)2.69640024
82eosinophil chemotaxis (GO:0048245)2.67601711
83B cell proliferation (GO:0042100)2.64890267
84tissue homeostasis (GO:0001894)2.63951583
85myeloid dendritic cell differentiation (GO:0043011)2.62708811
86intestinal absorption (GO:0050892)2.61222999
87T cell costimulation (GO:0031295)2.58117419
88regulation of T cell tolerance induction (GO:0002664)2.55459063
89protein-chromophore linkage (GO:0018298)2.54751787
90lymphocyte costimulation (GO:0031294)2.54192239
91regulation of necrotic cell death (GO:0010939)2.52910043
92negative regulation of B cell activation (GO:0050869)2.52164940
93positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.51533639
94respiratory burst (GO:0045730)2.50556545
95regulation of interferon-beta biosynthetic process (GO:0045357)2.47639817
96negative regulation of humoral immune response (GO:0002921)2.47122124
97regulation of B cell receptor signaling pathway (GO:0050855)2.45535451
98oligosaccharide biosynthetic process (GO:0009312)2.45332702
99negative regulation of complement activation (GO:0045916)2.45164604
100eosinophil migration (GO:0072677)2.43751516
101regulation of gamma-delta T cell activation (GO:0046643)2.42275663
102myeloid dendritic cell activation (GO:0001773)2.39446990
103regulation of vitamin metabolic process (GO:0030656)2.38266738
104antigen processing and presentation via MHC class Ib (GO:0002475)2.38085794
105interferon-gamma secretion (GO:0072643)2.38072010
106negative regulation of bone resorption (GO:0045779)2.37531185
107positive regulation by symbiont of host defense response (GO:0052509)2.35711397
108modulation by symbiont of host defense response (GO:0052031)2.35711397
109modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.35711397
110modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.35711397
111positive regulation by organism of defense response of other organism involved in symbiotic interact2.35711397
112modulation by symbiont of host immune response (GO:0052553)2.35711397
113regulation of B cell activation (GO:0050864)2.35665817
114dendritic cell migration (GO:0036336)2.35533709
115regulation of type I interferon-mediated signaling pathway (GO:0060338)2.35360319
116detection of biotic stimulus (GO:0009595)2.35311035
117ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.34668965
118I-kappaB phosphorylation (GO:0007252)2.34139142
119positive thymic T cell selection (GO:0045059)2.33885038
120defense response to protozoan (GO:0042832)2.32787423
121regulation of regulatory T cell differentiation (GO:0045589)2.30428621
122regulation of tolerance induction (GO:0002643)2.29958354
123macrophage activation involved in immune response (GO:0002281)2.29121453
124erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.27090297
125L-phenylalanine catabolic process (GO:0006559)2.27090297
126positive regulation of interleukin-4 production (GO:0032753)2.26226157
127purine deoxyribonucleotide catabolic process (GO:0009155)2.22818518
128COPI coating of Golgi vesicle (GO:0048205)2.20704300
129Golgi transport vesicle coating (GO:0048200)2.20704300
130benzene-containing compound metabolic process (GO:0042537)2.15952299
131negative regulation of interleukin-10 production (GO:0032693)2.15797460
132regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.14466859
133regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.11428420
134coenzyme catabolic process (GO:0009109)2.11295823
135regulation of macrophage cytokine production (GO:0010935)2.11123550
136mast cell degranulation (GO:0043303)2.09482435
137mast cell activation involved in immune response (GO:0002279)2.09482435
138positive regulation of Rap GTPase activity (GO:0032854)2.04223808
139aminoglycoside antibiotic metabolic process (GO:0030647)2.04050990
140regulation of interleukin-12 biosynthetic process (GO:0045075)2.03884436
141positive regulation of production of molecular mediator of immune response (GO:0002702)2.03032590
142locomotory exploration behavior (GO:0035641)2.00852823
143negative thymic T cell selection (GO:0045060)2.00787942
144protein activation cascade (GO:0072376)13.9304290
145immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:000211.4026669
146Fc-gamma receptor signaling pathway (GO:0038094)11.4026669
147Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)11.4026669
148Fc receptor mediated stimulatory signaling pathway (GO:0002431)11.2763990
149retina homeostasis (GO:0001895)10.7491647
150protein N-linked glycosylation via asparagine (GO:0018279)1.99792560
151primary alcohol catabolic process (GO:0034310)1.99545752
152antigen receptor-mediated signaling pathway (GO:0050851)1.99108784
153negative regulation of fatty acid biosynthetic process (GO:0045717)1.98872501
154aldehyde catabolic process (GO:0046185)1.98792705
155detection of molecule of bacterial origin (GO:0032490)1.97991659
156regulation of immunoglobulin production (GO:0002637)1.97949765
157positive regulation of excitatory postsynaptic membrane potential (GO:2000463)1.95829459
158N-glycan processing (GO:0006491)1.94967428
159protein maturation by protein folding (GO:0022417)1.94590091
160peptidyl-asparagine modification (GO:0018196)1.93761236
161T cell lineage commitment (GO:0002360)1.93752196
162production of molecular mediator involved in inflammatory response (GO:0002532)1.92215549
163L-phenylalanine metabolic process (GO:0006558)1.90373403
164erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)1.90373403
165aromatic amino acid family catabolic process (GO:0009074)1.90259610
166neutrophil activation involved in immune response (GO:0002283)1.89891110
167glutamine family amino acid biosynthetic process (GO:0009084)1.86788867
168mature B cell differentiation (GO:0002335)1.86577740
169antibacterial humoral response (GO:0019731)1.86429908
170protein N-linked glycosylation (GO:0006487)1.84480222
171maternal placenta development (GO:0001893)1.84306676
172opsonization (GO:0008228)1.84059276
173negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)1.84020063
174positive regulation of Rho protein signal transduction (GO:0035025)1.83854149
175proline metabolic process (GO:0006560)1.80522993

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.75453744
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.90320193
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.62858973
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.48596736
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.30626913
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.16224822
7GATA1_22025678_ChIP-Seq_K562_Human3.81881475
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.69225660
9TP63_17297297_ChIP-ChIP_HaCaT_Human3.49012299
10DROSHA_22980978_ChIP-Seq_HELA_Human3.21328026
11E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human3.20327464
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.19484612
13MYC_22102868_ChIP-Seq_BL_Human3.06405565
14IKZF1_21737484_ChIP-ChIP_HCT116_Human2.94125407
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.82616819
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.82374711
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.73019871
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.67051540
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.66797457
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.63653056
21IRF8_27001747_Chip-Seq_BMDM_Mouse2.56979666
22CDX2_20551321_ChIP-Seq_CACO-2_Human2.42464703
23RUNX_20019798_ChIP-Seq_JUKART_Human2.26890408
24PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.21152686
25PPARA_22158963_ChIP-Seq_LIVER_Mouse2.18680479
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.12573146
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.05722606
28SCL_19346495_ChIP-Seq_HPC-7_Human2.03834867
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.02559789
30EGR1_19374776_ChIP-ChIP_THP-1_Human2.01755242
31MAF_26560356_Chip-Seq_TH1_Human1.97244069
32RXR_22158963_ChIP-Seq_LIVER_Mouse1.97001080
33SOX2_27498859_Chip-Seq_STOMACH_Mouse1.92153461
34EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.91067150
35LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.86870388
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.85472633
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.85393133
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.84819296
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.83617777
40PU.1_20513432_ChIP-Seq_Bcells_Mouse1.82203980
41VDR_24763502_ChIP-Seq_THP-1_Human1.77804393
42CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.75038009
43STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.74802641
44E2F7_22180533_ChIP-Seq_HELA_Human1.73007298
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.72780634
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.69884929
47STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.67093872
48GATA3_26560356_Chip-Seq_TH2_Human1.65411373
49TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.62569007
50SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61797649
51MYB_26560356_Chip-Seq_TH2_Human1.60613343
52VDR_21846776_ChIP-Seq_THP-1_Human1.60126437
53RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.58416926
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.56869484
55CLOCK_20551151_ChIP-Seq_293T_Human1.55412028
56SOX2_20726797_ChIP-Seq_SW620_Human1.54190806
57FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.53984428
58Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.51247571
59FOXO3_23340844_ChIP-Seq_DLD1_Human1.49991944
60MYB_26560356_Chip-Seq_TH1_Human1.49071575
61TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39402999
62BRD4_27068464_Chip-Seq_AML-cells_Mouse1.38506984
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37411125
64FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.37228865
65NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36083526
66LXR_22158963_ChIP-Seq_LIVER_Mouse1.35518064
67GATA4_25053715_ChIP-Seq_YYC3_Human1.35125028
68GATA3_27048872_Chip-Seq_THYMUS_Human1.33687234
69MYB_21317192_ChIP-Seq_ERMYB_Mouse1.31308666
70EGR1_23403033_ChIP-Seq_LIVER_Mouse1.29318406
71UTX_26944678_Chip-Seq_JUKART_Human1.26637333
72GATA1_19941826_ChIP-Seq_K562_Human1.26226796
73CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.26082326
74ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.26037294
75LXR_22292898_ChIP-Seq_THP-1_Human1.25499060
76KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24228784
77EGR1_19032775_ChIP-ChIP_M12_Human1.23717550
78VDR_24787735_ChIP-Seq_THP-1_Human1.20301073
79STAT1_20625510_ChIP-Seq_HELA_Human1.20286725
80GATA6_25053715_ChIP-Seq_YYC3_Human1.18893780
81GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17913304
82ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17536155
83BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16015454
84GATA2_21666600_ChIP-Seq_HMVEC_Human1.15029270
85MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14999936
86SPI1_23547873_ChIP-Seq_NB4_Human1.14158107
87RARG_19884340_ChIP-ChIP_MEFs_Mouse1.13952819
88SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.13742267
89ESR2_21235772_ChIP-Seq_MCF-7_Human1.13591776
90GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12714559
91TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.12543827
92FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.12362376
93LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10287030
94CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09663071
95ESR1_21235772_ChIP-Seq_MCF-7_Human1.08968406
96CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08388108
97CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.07479383
98KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07446088
99NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07404195
100NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07404195
101NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.07051372
102PPAR_26484153_Chip-Seq_NCI-H1993_Human1.06272542
103BCL6_27268052_Chip-Seq_Bcells_Human1.05814690
104RACK7_27058665_Chip-Seq_MCF-7_Human1.04795529
105P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04449836
106CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.04032429
107SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01865027
108GATA1_19941827_ChIP-Seq_MEL_Mouse1.01654726
109TCF4_18268006_ChIP-ChIP_LS174T_Human0.97901007
110MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97638354
111STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96599954
112HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95708561
113ELK3_25401928_ChIP-Seq_HUVEC_Human0.94947365
114TRIM28_21343339_ChIP-Seq_HEK293_Human0.94129223
115TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93770802
116SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.93446820
117PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93178173
118KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92274706
119E2F1_17053090_ChIP-ChIP_MCF-7_Human0.89260958
120PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88299524
121GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88044576
122SPI1_23127762_ChIP-Seq_K562_Human0.88042198
123RUNX1_27514584_Chip-Seq_MCF-7_Human0.87991693
124DNAJC2_21179169_ChIP-ChIP_NT2_Human0.87764888
125KDM2B_26808549_Chip-Seq_DND41_Human0.87713770
126FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87246529
127GATA2_19941826_ChIP-Seq_K562_Human0.86619678
128TCF7_22412390_ChIP-Seq_EML_Mouse0.86137857
129KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.85562590
130SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85044242
131ELF1_20517297_ChIP-Seq_JURKAT_Human0.83401194
132ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.82965731
133GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.82755518
134TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81303254
135SA1_27219007_Chip-Seq_Bcells_Human0.79143088
136RUNX1_22412390_ChIP-Seq_EML_Mouse0.78920514
137MAF_26560356_Chip-Seq_TH2_Human0.78854819
138NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.78819135
139SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.77731419
140CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77518261
141CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77428212
142KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.77049914
143CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.76863269

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.77150752
2MP0001800_abnormal_humoral_immune4.15219536
3MP0003724_increased_susceptibility_to4.14774907
4MP0003303_peritoneal_inflammation3.71112054
5MP0005671_abnormal_response_to3.69748780
6MP0005387_immune_system_phenotype3.13759897
7MP0001790_abnormal_immune_system3.13759897
8MP0002452_abnormal_antigen_presenting2.95934439
9MP0006054_spinal_hemorrhage2.75068672
10MP0002723_abnormal_immune_serum2.64132604
11MP0002148_abnormal_hypersensitivity_rea2.59404607
12MP0002139_abnormal_hepatobiliary_system2.40428239
13MP0002420_abnormal_adaptive_immunity2.38642900
14MP0005360_urolithiasis2.36630415
15MP0001819_abnormal_immune_cell2.32436111
16MP0005000_abnormal_immune_tolerance2.30865958
17MP0000920_abnormal_myelination2.18651259
18MP0002398_abnormal_bone_marrow2.18596694
19MP0000716_abnormal_immune_system2.18199660
20MP0004264_abnormal_extraembryonic_tissu2.16968099
21MP0001873_stomach_inflammation2.14331248
22MP0005166_decreased_susceptibility_to2.11014819
23MP0000685_abnormal_immune_system2.06184094
24MP0005275_abnormal_skin_tensile2.00425046
25MP0002166_altered_tumor_susceptibility1.96996395
26MP0005025_abnormal_response_to1.96956685
27MP0002138_abnormal_hepatobiliary_system1.96315103
28MP0000689_abnormal_spleen_morphology1.94144104
29MP0003183_abnormal_peptide_metabolism1.91223534
30MP0004782_abnormal_surfactant_physiolog1.90802870
31MP0001533_abnormal_skeleton_physiology1.90471125
32MP0002419_abnormal_innate_immunity1.85055488
33MP0010234_abnormal_vibrissa_follicle1.84222049
34MP0002429_abnormal_blood_cell1.75487148
35MP0005085_abnormal_gallbladder_physiolo1.74834812
36MP0005623_abnormal_meninges_morphology1.66899863
37MP0004147_increased_porphyrin_level1.59055087
38MP0008004_abnormal_stomach_pH1.54049089
39MP0001845_abnormal_inflammatory_respons1.51848868
40MP0002722_abnormal_immune_system1.51758368
41MP0002876_abnormal_thyroid_physiology1.50173745
42MP0004947_skin_inflammation1.49552506
43MP0004858_abnormal_nervous_system1.48829363
44MP0002396_abnormal_hematopoietic_system1.47936110
45MP0009785_altered_susceptibility_to1.47666554
46MP0008438_abnormal_cutaneous_collagen1.47470829
47MP0002006_tumorigenesis1.46786318
48MP0004859_abnormal_synaptic_plasticity1.46221017
49MP0003690_abnormal_glial_cell1.45485503
50MP0003880_abnormal_central_pattern1.44537524
51MP0003300_gastrointestinal_ulcer1.37566350
52MP0003448_altered_tumor_morphology1.37262472
53MP0003191_abnormal_cellular_cholesterol1.34423031
54MP0000465_gastrointestinal_hemorrhage1.29967741
55MP0005584_abnormal_enzyme/coenzyme_acti1.29631820
56MP0001879_abnormal_lymphatic_vessel1.28755596
57MP0003705_abnormal_hypodermis_morpholog1.27324752
58MP0005023_abnormal_wound_healing1.26997001
59MP0003075_altered_response_to1.25692053
60MP0003045_fibrosis1.24578596
61MP0005503_abnormal_tendon_morphology1.24552925
62MP0003436_decreased_susceptibility_to1.22877404
63MP0002998_abnormal_bone_remodeling1.22558527
64MP0005083_abnormal_biliary_tract1.22163918
65MP0002405_respiratory_system_inflammati1.21809665
66MP0005381_digestive/alimentary_phenotyp1.20779628
67MP0002796_impaired_skin_barrier1.20697379
68MP0000490_abnormal_crypts_of1.20260114
69MP0005464_abnormal_platelet_physiology1.18021976
70MP0000477_abnormal_intestine_morphology1.17882972
71MP0005310_abnormal_salivary_gland1.16907813
72MP0009046_muscle_twitch1.14695438
73MP0003329_amyloid_beta_deposits1.13699016
74MP0008569_lethality_at_weaning1.13617841
75MP0000858_altered_metastatic_potential1.11439170
76MP0000343_altered_response_to1.10074251
77MP0002933_joint_inflammation1.08721782
78MP0003763_abnormal_thymus_physiology1.08024558
79MP0009840_abnormal_foam_cell1.07536611
80MP0000604_amyloidosis1.05638189
81MP0008875_abnormal_xenobiotic_pharmacok1.05535339
82MP0006082_CNS_inflammation1.04634841
83MP0003279_aneurysm1.04329636
84MP0005332_abnormal_amino_acid1.03971706
85MP0001664_abnormal_digestion1.03472848
86MP0003453_abnormal_keratinocyte_physiol1.03363772
87MP0010352_gastrointestinal_tract_polyps1.03362069
88MP0002272_abnormal_nervous_system1.02457146
89MP0009333_abnormal_splenocyte_physiolog1.02203725
90MP0005390_skeleton_phenotype0.98702527
91MP0004885_abnormal_endolymph0.95639285
92MP0003091_abnormal_cell_migration0.95572821
93MP0003866_abnormal_defecation0.95299904
94MP0001958_emphysema0.94895128
95MP0001851_eye_inflammation0.94861836
96MP0008469_abnormal_protein_level0.93420837
97MP0005365_abnormal_bile_salt0.92525158
98MP0000249_abnormal_blood_vessel0.91887744
99MP0005409_darkened_coat_color0.91531095
100MP0003868_abnormal_feces_composition0.91383136
101MP0005164_abnormal_response_to0.91267349
102MP0002133_abnormal_respiratory_system0.90416714
103MP0005388_respiratory_system_phenotype0.90416714
104MP0003566_abnormal_cell_adhesion0.90275339
105MP0004084_abnormal_cardiac_muscle0.90161069
106MP0002064_seizures0.90052333
107MP0002136_abnormal_kidney_physiology0.87987439
108MP0001968_abnormal_touch/_nociception0.87002600
109MP0001905_abnormal_dopamine_level0.86820118
110MP0001853_heart_inflammation0.86284669
111MP0010155_abnormal_intestine_physiology0.85184536
112MP0001666_abnormal_nutrient_absorption0.84464352
113MP0004142_abnormal_muscle_tone0.83506093
114MP0003806_abnormal_nucleotide_metabolis0.82857649
115MP0005165_increased_susceptibility_to0.82823013
116MP0002736_abnormal_nociception_after0.82739961
117MP0003656_abnormal_erythrocyte_physiolo0.81832723
118MP0005451_abnormal_body_composition0.81309792
119MP0002837_dystrophic_cardiac_calcinosis0.81268975
120MP0003633_abnormal_nervous_system0.81152401
121MP0002277_abnormal_respiratory_mucosa0.80239782
122MP0000681_abnormal_thyroid_gland0.79521161
123MP0009643_abnormal_urine_homeostasis0.79320902
124MP0005058_abnormal_lysosome_morphology0.78158775
125MP0003795_abnormal_bone_structure0.78073186
126MP0004036_abnormal_muscle_relaxation0.77636710
127MP0003635_abnormal_synaptic_transmissio0.76431594
128MP0001529_abnormal_vocalization0.75816519
129MP0001216_abnormal_epidermal_layer0.75219869
130MP0004134_abnormal_chest_morphology0.74657127
131MP0000609_abnormal_liver_physiology0.73629740
132MP0005397_hematopoietic_system_phenotyp0.73221717
133MP0001545_abnormal_hematopoietic_system0.73221717
134MP0001177_atelectasis0.73009669
135MP0008872_abnormal_physiological_respon0.72261706
136MP0003828_pulmonary_edema0.71368214
137MP0004510_myositis0.70185137
138MP0009764_decreased_sensitivity_to0.69441342
139MP0002019_abnormal_tumor_incidence0.69185388
140MP0010329_abnormal_lipoprotein_level0.68933139
141MP0005535_abnormal_body_temperature0.68907775
142MP0001663_abnormal_digestive_system0.68546262
143MP0003186_abnormal_redox_activity0.68523843
144MP0002873_normal_phenotype0.68070231
145MP0002169_no_abnormal_phenotype0.67173564

Predicted human phenotypes

RankGene SetZ-score
1B lymphocytopenia (HP:0010976)7.69360870
2Abnormality of B cell number (HP:0010975)7.69360870
3Agammaglobulinemia (HP:0004432)7.00703433
4Systemic lupus erythematosus (HP:0002725)5.99176768
5Recurrent sinusitis (HP:0011108)5.61791888
6Recurrent bronchitis (HP:0002837)5.46233745
7Prostate neoplasm (HP:0100787)5.25984145
8Gastrointestinal stroma tumor (HP:0100723)4.92198183
9Cellulitis (HP:0100658)4.89973870
10Abnormality of macrophages (HP:0004311)4.69318301
11Verrucae (HP:0200043)4.39417649
12Papilloma (HP:0012740)4.39417649
13IgM deficiency (HP:0002850)4.28444144
14Malnutrition (HP:0004395)4.26568607
15Thyroiditis (HP:0100646)4.02360801
16Meningitis (HP:0001287)4.00269494
17Abnormality of complement system (HP:0005339)3.93938356
18Abnormality of the prostate (HP:0008775)3.87587152
19Recurrent viral infections (HP:0004429)3.85906893
20Recurrent pneumonia (HP:0006532)3.82109032
21Colitis (HP:0002583)3.79882739
22Panhypogammaglobulinemia (HP:0003139)3.69690843
23Glomerulonephritis (HP:0000099)3.66601578
24Complement deficiency (HP:0004431)3.63644934
25Hypoplasia of the thymus (HP:0000778)3.56362379
26Chronic otitis media (HP:0000389)3.55445796
27Hyperactive renin-angiotensin system (HP:0000841)3.34670344
28Chronic sinusitis (HP:0011109)3.33691944
29Mitral stenosis (HP:0001718)3.27907661
30Interstitial pulmonary disease (HP:0006530)3.17106267
31Acute encephalopathy (HP:0006846)3.13092498
32Nephritis (HP:0000123)3.08277781
33Spontaneous hematomas (HP:0007420)3.08122353
34Increased IgE level (HP:0003212)3.07751129
35Gastrointestinal infarctions (HP:0005244)3.07699621
36Premature loss of primary teeth (HP:0006323)3.07320954
37Acute necrotizing encephalopathy (HP:0006965)3.06269140
38Chronic diarrhea (HP:0002028)3.02086276
39Elevated erythrocyte sedimentation rate (HP:0003565)2.99987131
40Inflammation of the large intestine (HP:0002037)2.94888159
41Recurrent lower respiratory tract infections (HP:0002783)2.94008014
42Progressive macrocephaly (HP:0004481)2.93253892
43Osteomyelitis (HP:0002754)2.93083403
44Bronchitis (HP:0012387)2.91859146
45Sepsis (HP:0100806)2.83528200
46IgG deficiency (HP:0004315)2.80844266
47Gingivitis (HP:0000230)2.79374328
48Recurrent otitis media (HP:0000403)2.77301802
49Leukocytosis (HP:0001974)2.76744539
50Myositis (HP:0100614)2.76616601
51Gastrointestinal inflammation (HP:0004386)2.76597071
52Urticaria (HP:0001025)2.66303182
53Abnormality of small intestinal villus morphology (HP:0011472)2.65480396
54Villous atrophy (HP:0011473)2.65480396
55Right ventricular cardiomyopathy (HP:0011663)2.63219281
56Skin rash (HP:0000988)2.61819809
57Leukodystrophy (HP:0002415)2.59186807
58Vacuolated lymphocytes (HP:0001922)2.58814379
59Alopecia of scalp (HP:0002293)2.58299378
60Abnormality of glutamine family amino acid metabolism (HP:0010902)2.57638096
61Emphysema (HP:0002097)2.57079554
62Abnormal mitochondria in muscle tissue (HP:0008316)2.55108156
63Restrictive lung disease (HP:0002091)2.54485756
64Abnormality of the nasal mucosa (HP:0000433)2.54054183
65Abnormality of T cell number (HP:0011839)2.52730211
66Hyperventilation (HP:0002883)2.49081927
67Hemoptysis (HP:0002105)2.46445574
68Mediastinal lymphadenopathy (HP:0100721)2.46279920
69Abnormality of monocarboxylic acid metabolism (HP:0010996)2.45945984
70Decreased circulating renin level (HP:0003351)2.45742076
71Hypoproteinemia (HP:0003075)2.45110001
72Abnormality of T cell physiology (HP:0011840)2.44523838
73T lymphocytopenia (HP:0005403)2.43021712
74Acrocyanosis (HP:0001063)2.42379099
75Mucosal telangiectasiae (HP:0100579)2.41814362
76Vasculitis (HP:0002633)2.41438041
77Severe combined immunodeficiency (HP:0004430)2.41235894
78Recurrent abscess formation (HP:0002722)2.39992601
79Xerostomia (HP:0000217)2.37816845
80Orchitis (HP:0100796)2.37756691
81Recurrent bacterial skin infections (HP:0005406)2.35183492
82Nonimmune hydrops fetalis (HP:0001790)2.29528036
83Abnormality of T cells (HP:0002843)2.29389108
84Combined immunodeficiency (HP:0005387)2.29351668
85Pulmonary infiltrates (HP:0002113)2.26556589
86Abnormality of male internal genitalia (HP:0000022)2.25909661
87Conjunctival hamartoma (HP:0100780)2.25365251
88Chronic obstructive pulmonary disease (HP:0006510)2.24667178
89Obstructive lung disease (HP:0006536)2.24667178
90Pustule (HP:0200039)2.23853275
91Osteolytic defects of the hand bones (HP:0009699)2.22476693
92Osteolytic defects of the phalanges of the hand (HP:0009771)2.22476693
93Dysostosis multiplex (HP:0000943)2.20319735
94Recurrent fungal infections (HP:0002841)2.19116745
95IgA deficiency (HP:0002720)2.17462932
96Hypergammaglobulinemia (HP:0010702)2.13263662
97Chronic mucocutaneous candidiasis (HP:0002728)2.13121768
98Recurrent cutaneous fungal infections (HP:0011370)2.13121768
99Deep venous thrombosis (HP:0002625)2.11416255
100Abnormal gallbladder morphology (HP:0012437)2.10907626
101Periodontitis (HP:0000704)2.10686572
102Neoplasm of the lung (HP:0100526)2.10483410
103Flat acetabular roof (HP:0003180)2.10477139
104Cerebral edema (HP:0002181)2.09674364
105Hypertensive crisis (HP:0100735)2.06516383
106Cholelithiasis (HP:0001081)2.05985143
107Recurrent gram-negative bacterial infections (HP:0005420)2.02123592
108Abnormality of aromatic amino acid family metabolism (HP:0004338)2.01504629
109Autoimmune hemolytic anemia (HP:0001890)1.99811062
110Abnormality of renin-angiotensin system (HP:0000847)1.99768674
111Autoimmune thrombocytopenia (HP:0001973)1.99440677
112Macroorchidism (HP:0000053)1.99211734
113Hematochezia (HP:0002573)1.99024590
114Metabolic alkalosis (HP:0200114)1.96362187
115Abnormality of the intrinsic pathway (HP:0010989)1.96229419
116Recurrent skin infections (HP:0001581)1.95829092
117Ankyloglossia (HP:0010296)1.94392811
118Alkalosis (HP:0001948)1.93784047
119Keratoconjunctivitis sicca (HP:0001097)1.92407159
120Lymphopenia (HP:0001888)1.91788265
121Metaphyseal cupping (HP:0003021)1.91726241
122Fragile skin (HP:0001030)1.91338504
123Retrobulbar optic neuritis (HP:0100654)1.91257054
124Optic neuritis (HP:0100653)1.91257054
125Chest pain (HP:0100749)1.90574889
126Ileus (HP:0002595)1.89480494
127Hypermelanotic macule (HP:0001034)1.88664728
128Hepatocellular necrosis (HP:0001404)1.87486108
129Abnormality of the peritoneum (HP:0002585)1.85888647
130Supranuclear gaze palsy (HP:0000605)1.85407689
131Abnormality of primary teeth (HP:0006481)1.85343895
132Pheochromocytoma (HP:0002666)1.84645608
133Increased IgM level (HP:0003496)1.84509127
134Skin ulcer (HP:0200042)1.83029822
135Abnormality of cells of the lymphoid lineage (HP:0012140)1.82160294
136Eosinophilia (HP:0001880)1.79901635
137Arthralgia (HP:0002829)1.72424516
138Colon cancer (HP:0003003)1.72422713
139Eczematoid dermatitis (HP:0000976)1.72155554
140Sensory axonal neuropathy (HP:0003390)1.71820265
141Purpura (HP:0000979)1.70867487
142Intrahepatic cholestasis (HP:0001406)1.70861254
143Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.70538616
144Keratoconjunctivitis (HP:0001096)1.69771444
145Neuroendocrine neoplasm (HP:0100634)1.67614413
146Alacrima (HP:0000522)1.65982252
147Hepatic necrosis (HP:0002605)1.63737315
148Mitochondrial inheritance (HP:0001427)1.61799936
149Nasal polyposis (HP:0100582)1.59455261
150Xanthomatosis (HP:0000991)1.56861618
151Abnormal delayed hypersensitivity skin test (HP:0002963)1.56434124
152Hyperbilirubinemia (HP:0002904)1.55653230
153Camptodactyly of toe (HP:0001836)1.54958606
154Prolonged partial thromboplastin time (HP:0003645)1.54559561
155Mucopolysacchariduria (HP:0008155)1.53863638
156Urinary glycosaminoglycan excretion (HP:0003541)1.53863638
157Generalized myoclonic seizures (HP:0002123)1.53360390
158Cerebral hemorrhage (HP:0001342)1.52383668

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.86876596
2ERN13.79420871
3MST1R3.33878756
4IRAK43.06023754
5PRPF4B2.97600428
6KIT2.88499955
7CSF1R2.66669672
8RIPK42.63399408
9RIPK12.59034888
10EPHA32.43079216
11GRK62.23536572
12SYK2.13330326
13FGFR21.99846745
14EPHB11.99054525
15MAP3K41.98805773
16SIK21.96196482
17MAP3K131.95125238
18FRK1.88801423
19FES1.88723623
20TYK21.85347372
21BCKDK1.84559464
22TBK11.81797074
23LYN1.71172979
24ADRBK21.67080932
25PIK3CA1.63873548
26PKN11.63250761
27MST41.61148503
28MAP3K141.59356648
29BMX1.56081836
30SIK11.51300708
31ZAP701.50076136
32NME21.46508296
33BUB11.45386331
34CLK11.44300481
35UHMK11.41672111
36BTK1.39027400
37ACVR1B1.36833460
38HIPK21.32500180
39MAP3K11.27895238
40PRKCH1.27322050
41NEK21.24768187
42PDGFRA1.23060339
43TNIK1.22817542
44STK241.22425137
45ITK1.19376509
46EPHA21.17294356
47IRAK31.16179229
48IRAK11.14512544
49PRKCQ1.12462436
50TTN1.12234304
51MET1.10774066
52FER1.09432760
53HCK1.06962262
54BLK1.03594455
55TRIB31.01860211
56PIK3CG1.01798949
57TXK1.01737798
58NLK1.01502732
59SMG10.94936494
60NEK10.94639038
61DDR20.92517799
62STK100.92288818
63JAK10.92271115
64CSNK1G30.91588799
65LCK0.89544254
66PTK60.85101588
67EIF2AK30.84226935
68PKN20.84082598
69IKBKE0.83888754
70YES10.83359322
71TAOK10.82971482
72MATK0.79917459
73IKBKB0.79791484
74CSNK1A1L0.79717514
75EPHB20.79001941
76KSR20.77037670
77RET0.75404379
78TGFBR20.74070931
79MAP3K30.73508903
80MYLK0.73378591
81NTRK30.72841659
82FGFR30.72753514
83PRKD10.72479515
84CSNK1G20.71245960
85FGR0.69479515
86MAPK70.66852451
87LMTK20.65201956
88ALK0.63757480
89MAP3K20.63495028
90MAPK120.61539737
91EPHA40.60978951
92PDPK10.60849590
93FYN0.60624288
94ROCK20.60441468
95DMPK0.59363441
96PRKCD0.59326450
97MAP3K60.59241181
98LRRK20.59065037
99CDC42BPA0.58497950
100MARK30.56055164
101MAPK130.56026171
102CSNK1G10.54416812
103PDGFRB0.53366276
104JAK30.53111804
105MAP2K30.52988862
106CDK60.52515151
107TGFBR10.51859409
108CSK0.51725146
109MAP3K90.50973733
110RPS6KA60.50788272
111ICK0.50072900
112RPS6KC10.49449623
113RPS6KL10.49449623
114NME10.49349092
115PIM10.49182572
116PRKG20.48493961
117EEF2K0.46150836
118NEK90.45971672
119MAPK110.45862103
120MINK10.45836065
121PAK30.45142337
122PAK40.45062664
123BMPR20.45023784
124STK390.44444731
125BRSK10.44139213
126OXSR10.43943082
127FGFR40.43683993
128CAMK2A0.41222025
129MAP3K100.40932325
130TESK20.39903091
131SIK30.39371604
132INSR0.38263609
133PDK10.38044720
134CDK50.36735732
135MAPKAPK20.36631140
136PRKCZ0.36546379
137BCR0.35933570
138JAK20.35555531
139MAP2K20.35070460
140IGF1R0.34932496
141TEC0.34129033
142GRK50.33840258
143ROCK10.33781984
144MAPK40.33053937
145SRC0.32456496
146ABL10.30834362
147TAOK20.30762047
148TAOK30.30580062
149TESK10.28435996
150PRKD20.26675637

Predicted pathways (KEGG)

RankGene SetZ-score
1Intestinal immune network for IgA production_Homo sapiens_hsa046728.09141511
2Primary immunodeficiency_Homo sapiens_hsa053404.54551022
3Protein export_Homo sapiens_hsa030604.41832637
4B cell receptor signaling pathway_Homo sapiens_hsa046623.35062404
5Autoimmune thyroid disease_Homo sapiens_hsa053203.16991618
6Graft-versus-host disease_Homo sapiens_hsa053323.04242923
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.02975850
8Type I diabetes mellitus_Homo sapiens_hsa049402.49977988
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.27599955
10Cyanoamino acid metabolism_Homo sapiens_hsa004602.11508149
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.08088171
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.80600641
13Primary bile acid biosynthesis_Homo sapiens_hsa001201.76453171
14N-Glycan biosynthesis_Homo sapiens_hsa005101.69766947
15Toxoplasmosis_Homo sapiens_hsa051451.69256564
16Folate biosynthesis_Homo sapiens_hsa007901.55211922
17Arginine biosynthesis_Homo sapiens_hsa002201.55045621
18Asthma_Homo sapiens_hsa053101.49201162
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.46639789
20Influenza A_Homo sapiens_hsa051641.42622583
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.42373136
22Pyruvate metabolism_Homo sapiens_hsa006201.37892491
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.34267676
24Other glycan degradation_Homo sapiens_hsa005111.33786900
25Renin-angiotensin system_Homo sapiens_hsa046141.32764972
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.29952218
27Sulfur metabolism_Homo sapiens_hsa009201.24789902
28Proteasome_Homo sapiens_hsa030501.19313337
29Fat digestion and absorption_Homo sapiens_hsa049751.18482084
30Nitrogen metabolism_Homo sapiens_hsa009101.15268986
31Herpes simplex infection_Homo sapiens_hsa051681.14999208
32Staphylococcus aureus infection_Homo sapiens_hsa051501.10274785
33Leishmaniasis_Homo sapiens_hsa051401.09678812
34Alzheimers disease_Homo sapiens_hsa050101.08694430
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.06346107
36TNF signaling pathway_Homo sapiens_hsa046681.05889778
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05013878
38Fatty acid degradation_Homo sapiens_hsa000711.01474864
39Malaria_Homo sapiens_hsa051440.98759773
40Hepatitis C_Homo sapiens_hsa051600.98412344
41Protein digestion and absorption_Homo sapiens_hsa049740.97408338
42Antigen processing and presentation_Homo sapiens_hsa046120.96996671
43Tryptophan metabolism_Homo sapiens_hsa003800.96460122
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.96375819
45Non-homologous end-joining_Homo sapiens_hsa034500.96136086
46Toll-like receptor signaling pathway_Homo sapiens_hsa046200.95765038
47Mineral absorption_Homo sapiens_hsa049780.94249960
48Fructose and mannose metabolism_Homo sapiens_hsa000510.92985253
49Oxidative phosphorylation_Homo sapiens_hsa001900.92477130
50Phenylalanine metabolism_Homo sapiens_hsa003600.91424827
51Histidine metabolism_Homo sapiens_hsa003400.91327013
52Measles_Homo sapiens_hsa051620.90690156
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90260751
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87960486
55Caffeine metabolism_Homo sapiens_hsa002320.84323361
56Allograft rejection_Homo sapiens_hsa053300.84280098
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84237679
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83887427
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82813535
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81455918
61T cell receptor signaling pathway_Homo sapiens_hsa046600.80978939
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80826669
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80575859
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79978543
65beta-Alanine metabolism_Homo sapiens_hsa004100.79902827
66Jak-STAT signaling pathway_Homo sapiens_hsa046300.77427374
67Pertussis_Homo sapiens_hsa051330.76662211
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74495602
69Osteoclast differentiation_Homo sapiens_hsa043800.74392645
70Complement and coagulation cascades_Homo sapiens_hsa046100.74138473
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72733335
72Fatty acid elongation_Homo sapiens_hsa000620.71958509
73Parkinsons disease_Homo sapiens_hsa050120.71052690
74Amoebiasis_Homo sapiens_hsa051460.70844775
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70747984
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69802370
77Peroxisome_Homo sapiens_hsa041460.69703283
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69548225
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68042948
80Pancreatic secretion_Homo sapiens_hsa049720.67388136
81Fatty acid metabolism_Homo sapiens_hsa012120.66925171
82Vibrio cholerae infection_Homo sapiens_hsa051100.65515431
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65151556
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.64712655
85Acute myeloid leukemia_Homo sapiens_hsa052210.62874007
86Arachidonic acid metabolism_Homo sapiens_hsa005900.62520632
87DNA replication_Homo sapiens_hsa030300.62509882
88Type II diabetes mellitus_Homo sapiens_hsa049300.62394001
89Chemokine signaling pathway_Homo sapiens_hsa040620.62018567
90Tuberculosis_Homo sapiens_hsa051520.61428892
91Starch and sucrose metabolism_Homo sapiens_hsa005000.61381423
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.60595485
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60109720
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59199104
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.59118119
96Amphetamine addiction_Homo sapiens_hsa050310.57588524
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56759921
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56649563
99Long-term potentiation_Homo sapiens_hsa047200.56199929
100Systemic lupus erythematosus_Homo sapiens_hsa053220.55780093
101Apoptosis_Homo sapiens_hsa042100.55509499
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54939238
103Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54491135
104Hematopoietic cell lineage_Homo sapiens_hsa046400.53291819
105Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53017657
106Homologous recombination_Homo sapiens_hsa034400.52580191
107Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51253589
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.50719410
109Hepatitis B_Homo sapiens_hsa051610.49850612
110Phagosome_Homo sapiens_hsa041450.49717904
111Circadian entrainment_Homo sapiens_hsa047130.49507147
112Biosynthesis of amino acids_Homo sapiens_hsa012300.49373757
113Salmonella infection_Homo sapiens_hsa051320.49017897
114Galactose metabolism_Homo sapiens_hsa000520.48948690
115Propanoate metabolism_Homo sapiens_hsa006400.47960736
116Pancreatic cancer_Homo sapiens_hsa052120.47067617
117Glutamatergic synapse_Homo sapiens_hsa047240.46016086
118Butanoate metabolism_Homo sapiens_hsa006500.45312112
119Platelet activation_Homo sapiens_hsa046110.45089179
120Prolactin signaling pathway_Homo sapiens_hsa049170.44135149
121Viral myocarditis_Homo sapiens_hsa054160.44079560
122Renin secretion_Homo sapiens_hsa049240.43956813
123Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42066330
124Carbon metabolism_Homo sapiens_hsa012000.42029975
125GABAergic synapse_Homo sapiens_hsa047270.41584392
126Cholinergic synapse_Homo sapiens_hsa047250.41499273
127Vitamin digestion and absorption_Homo sapiens_hsa049770.41402498
128HTLV-I infection_Homo sapiens_hsa051660.39051374
129Retinol metabolism_Homo sapiens_hsa008300.38897089
130Linoleic acid metabolism_Homo sapiens_hsa005910.38496815
131Arginine and proline metabolism_Homo sapiens_hsa003300.37309297
132Lysosome_Homo sapiens_hsa041420.36975293
133HIF-1 signaling pathway_Homo sapiens_hsa040660.36741879
134Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34226515
135Renal cell carcinoma_Homo sapiens_hsa052110.34046416
136Glycosaminoglycan degradation_Homo sapiens_hsa005310.33912462
137Prion diseases_Homo sapiens_hsa050200.33460022
138Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33313518
139Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32901387
140Ribosome_Homo sapiens_hsa030100.32225465
141Epstein-Barr virus infection_Homo sapiens_hsa051690.32002534
142Chronic myeloid leukemia_Homo sapiens_hsa052200.31862668
143Rheumatoid arthritis_Homo sapiens_hsa053230.31794793
144Ether lipid metabolism_Homo sapiens_hsa005650.31661445
145Steroid hormone biosynthesis_Homo sapiens_hsa001400.31568654
146Legionellosis_Homo sapiens_hsa051340.30759008
147Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29939962
148Aldosterone synthesis and secretion_Homo sapiens_hsa049250.29694956
149GnRH signaling pathway_Homo sapiens_hsa049120.29356330
150Thyroid hormone synthesis_Homo sapiens_hsa049180.29204588
151Dopaminergic synapse_Homo sapiens_hsa047280.28881646
152African trypanosomiasis_Homo sapiens_hsa051430.28854927
153PPAR signaling pathway_Homo sapiens_hsa033200.26464902
154SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25245921
155Chemical carcinogenesis_Homo sapiens_hsa052040.24010636
156VEGF signaling pathway_Homo sapiens_hsa043700.23864138
157Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.23805309

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