IGKV1D-13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1complement activation (GO:0006956)9.99585267
2positive regulation of respiratory burst (GO:0060267)7.65755872
3protein activation cascade (GO:0072376)7.31677444
4glomerular filtration (GO:0003094)6.78545802
5immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00026.23288523
6Fc-gamma receptor signaling pathway (GO:0038094)6.23288523
7Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)6.23288523
8Fc receptor mediated stimulatory signaling pathway (GO:0002431)6.20134069
9renal filtration (GO:0097205)6.11030954
10humoral immune response (GO:0006959)5.61426481
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.40242217
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.31998117
13antigen processing and presentation of endogenous antigen (GO:0019883)5.11800598
14regulation of respiratory burst (GO:0060263)5.00100828
15antibacterial humoral response (GO:0019731)4.82449649
16antimicrobial humoral response (GO:0019730)4.77003330
17regulation of cellular extravasation (GO:0002691)4.59941894
18retina homeostasis (GO:0001895)4.22913504
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.04130596
20regulation of dendritic cell antigen processing and presentation (GO:0002604)3.97296703
21germinal center formation (GO:0002467)3.87294982
22immune response-activating cell surface receptor signaling pathway (GO:0002429)3.85423240
23immunoglobulin mediated immune response (GO:0016064)3.82866410
24regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.77588356
25chronic inflammatory response (GO:0002544)3.73121926
26negative regulation of cell killing (GO:0031342)3.71382551
27negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.71382551
28regulation of antigen processing and presentation (GO:0002577)3.66519131
29interferon-gamma-mediated signaling pathway (GO:0060333)3.55247634
30detection of other organism (GO:0098543)3.41991089
31detection of bacterium (GO:0016045)3.32959999
32production of molecular mediator involved in inflammatory response (GO:0002532)3.30203593
33positive regulation of gamma-delta T cell activation (GO:0046645)3.29595568
34positive regulation of antigen processing and presentation (GO:0002579)3.25863514
35regulation of integrin activation (GO:0033623)3.24920496
36cellular response to type I interferon (GO:0071357)3.20076647
37type I interferon signaling pathway (GO:0060337)3.20076647
38negative regulation of myotube differentiation (GO:0010832)3.16597969
39response to type I interferon (GO:0034340)3.16446207
40eosinophil chemotaxis (GO:0048245)3.04546176
41dendritic cell chemotaxis (GO:0002407)2.99667607
42immune response-activating signal transduction (GO:0002757)2.94098258
43wound healing, spreading of epidermal cells (GO:0035313)2.91982881
44negative regulation of complement activation (GO:0045916)2.90855256
45cellular extravasation (GO:0045123)2.90379120
46cellular response to interferon-gamma (GO:0071346)2.87790970
47regulation of B cell receptor signaling pathway (GO:0050855)2.87494319
48activation of immune response (GO:0002253)2.87125661
49B cell mediated immunity (GO:0019724)2.86392759
50eosinophil migration (GO:0072677)2.84165390
51positive regulation of Cdc42 GTPase activity (GO:0043089)2.81443317
52positive regulation of type 2 immune response (GO:0002830)2.81428439
53negative regulation of humoral immune response (GO:0002921)2.79973873
54surfactant homeostasis (GO:0043129)2.79165650
55response to interleukin-15 (GO:0070672)2.78129015
56detection of external biotic stimulus (GO:0098581)2.76324941
57regulation of T-helper 1 cell differentiation (GO:0045625)2.76272627
58response to interferon-gamma (GO:0034341)2.75191751
59respiratory burst (GO:0045730)2.74537535
60production of molecular mediator of immune response (GO:0002440)2.71365242
61regulation of T cell tolerance induction (GO:0002664)2.70691263
62leukocyte migration involved in inflammatory response (GO:0002523)2.66756820
63defense response to protozoan (GO:0042832)2.66171224
64dendritic cell migration (GO:0036336)2.65794168
65B cell receptor signaling pathway (GO:0050853)2.65459114
66regulation of necrotic cell death (GO:0010939)2.65251111
67positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.63674071
68positive regulation of chemokine secretion (GO:0090197)2.61770809
69protein-chromophore linkage (GO:0018298)2.59031727
70positive regulation of cellular response to oxidative stress (GO:1900409)2.58706008
71positive regulation of response to oxidative stress (GO:1902884)2.58706008
72myeloid dendritic cell differentiation (GO:0043011)2.58609664
73lymphocyte chemotaxis (GO:0048247)2.57462053
74positive regulation of T cell migration (GO:2000406)2.55546597
75regulation of chemokine secretion (GO:0090196)2.54531172
76negative regulation of protein activation cascade (GO:2000258)2.54209141
77T-helper 1 type immune response (GO:0042088)2.52086992
78positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.52006385
79regulation of glucose import in response to insulin stimulus (GO:2001273)2.50981932
80neutrophil activation involved in immune response (GO:0002283)2.49234926
81regulation of tolerance induction (GO:0002643)2.49232518
82negative regulation of bone resorption (GO:0045779)2.49198942
83regulation of T cell migration (GO:2000404)2.49086972
84regulation of regulatory T cell differentiation (GO:0045589)2.46306614
85lymph node development (GO:0048535)2.41120583
86positive regulation of B cell differentiation (GO:0045579)2.39269351
87modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.38220721
88positive regulation by organism of defense response of other organism involved in symbiotic interact2.38220721
89modulation by symbiont of host immune response (GO:0052553)2.38220721
90positive regulation by symbiont of host defense response (GO:0052509)2.38220721
91modulation by symbiont of host defense response (GO:0052031)2.38220721
92modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.38220721
93regulation of gamma-delta T cell activation (GO:0046643)2.37946263
94immune response-regulating cell surface receptor signaling pathway (GO:0002768)2.37207037
95positive regulation of pseudopodium assembly (GO:0031274)2.35802145
96macrophage activation involved in immune response (GO:0002281)2.35078161
97positive regulation of receptor recycling (GO:0001921)2.34329354
98positive regulation of granulocyte chemotaxis (GO:0071624)2.34247563
99myeloid dendritic cell activation (GO:0001773)2.34015716
100complement activation, classical pathway (GO:0006958)12.6033401

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.89581753
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.57292294
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.44816199
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.40053421
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.37807436
6RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.36268175
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.11153033
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.83657005
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.66965928
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.58216986
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.49546862
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.31944220
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.21713206
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.17203255
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.14248094
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.13008505
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.05791350
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.05791179
19RUNX_20019798_ChIP-Seq_JUKART_Human1.97268387
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.88016045
21BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.87474694
22STAT4_19710469_ChIP-ChIP_TH1__Mouse1.83861948
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.81269727
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.76265617
25E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.68523395
26MYB_26560356_Chip-Seq_TH2_Human1.60999050
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.60352456
28CDX2_20551321_ChIP-Seq_CACO-2_Human1.59455267
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.56636601
30EGR1_19032775_ChIP-ChIP_M12_Human1.55366045
31TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.53585590
32VDR_24763502_ChIP-Seq_THP-1_Human1.53270244
33SOX2_27498859_Chip-Seq_STOMACH_Mouse1.51937250
34CLOCK_20551151_ChIP-Seq_293T_Human1.47877388
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.44664164
36TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44114565
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.42531131
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.39625513
39SOX2_20726797_ChIP-Seq_SW620_Human1.37916032
40VDR_24787735_ChIP-Seq_THP-1_Human1.37590224
41GATA2_21666600_ChIP-Seq_HMVEC_Human1.36766352
42GATA1_22025678_ChIP-Seq_K562_Human1.35742906
43SPI1_23547873_ChIP-Seq_NB4_Human1.35636568
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.34861855
45SPI1_23127762_ChIP-Seq_K562_Human1.34693174
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.33995448
47FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.32719488
48CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27337537
49FOXO3_23340844_ChIP-Seq_DLD1_Human1.26895209
50MAF_26560356_Chip-Seq_TH1_Human1.23339920
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.22064793
52MYB_26560356_Chip-Seq_TH1_Human1.19570433
53SCL_19346495_ChIP-Seq_HPC-7_Human1.17638778
54GATA1_19941826_ChIP-Seq_K562_Human1.14508772
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14354891
56CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.14169160
57CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14039179
58NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.12820611
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10355222
60STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09103986
61GATA4_25053715_ChIP-Seq_YYC3_Human1.08532478
62SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08114678
63RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.08098065
64LXR_22292898_ChIP-Seq_THP-1_Human1.07843733
65SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.06585830
66VDR_21846776_ChIP-Seq_THP-1_Human1.05185509
67ESR2_21235772_ChIP-Seq_MCF-7_Human1.04315674
68GATA3_27048872_Chip-Seq_THYMUS_Human1.04151345
69RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03993205
70LXR_22158963_ChIP-Seq_LIVER_Mouse1.02816859
71UTX_26944678_Chip-Seq_JUKART_Human1.01911323
72ESR1_21235772_ChIP-Seq_MCF-7_Human1.01200424
73MYC_22102868_ChIP-Seq_BL_Human0.99261003
74TCF7_22412390_ChIP-Seq_EML_Mouse0.99160947
75ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97693990
76GATA2_19941826_ChIP-Seq_K562_Human0.94374304
77ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94114294
78LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94102556
79ELK3_25401928_ChIP-Seq_HUVEC_Human0.93869418
80GATA1_19941827_ChIP-Seq_MEL_Mouse0.93359106
81KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92837279
82MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.92754697
83CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91679149
84RXR_22158963_ChIP-Seq_LIVER_Mouse0.91052423
85ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.90401432
86GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89122045
87GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88722335
88PPARA_22158963_ChIP-Seq_LIVER_Mouse0.88532356
89PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87570098
90PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86567053
91PPAR_26484153_Chip-Seq_NCI-H1993_Human0.86449764
92PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85758107
93P63_26484246_Chip-Seq_KERATINOCYTES_Human0.84831151
94PU_27001747_Chip-Seq_BMDM_Mouse0.84723086
95GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82483573
96PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.82032234
97TCF4_18268006_ChIP-ChIP_LS174T_Human0.81968799
98CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81738918
99PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.81457699
100TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.80759491

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.33241171
2MP0003303_peritoneal_inflammation4.34008012
3MP0003436_decreased_susceptibility_to3.28836523
4MP0001835_abnormal_antigen_presentation3.27639094
5MP0005387_immune_system_phenotype2.93146205
6MP0001790_abnormal_immune_system2.93146205
7MP0001800_abnormal_humoral_immune2.73054947
8MP0010155_abnormal_intestine_physiology2.66867675
9MP0005025_abnormal_response_to2.61579588
10MP0010234_abnormal_vibrissa_follicle2.42158989
11MP0000685_abnormal_immune_system2.41101796
12MP0005000_abnormal_immune_tolerance2.38910068
13MP0009785_altered_susceptibility_to2.38030789
14MP0002148_abnormal_hypersensitivity_rea2.27559406
15MP0005166_decreased_susceptibility_to2.27375274
16MP0000465_gastrointestinal_hemorrhage2.24698600
17MP0001533_abnormal_skeleton_physiology2.21799320
18MP0003300_gastrointestinal_ulcer2.20206086
19MP0002419_abnormal_innate_immunity2.17226148
20MP0002452_abnormal_antigen_presenting2.17068829
21MP0005671_abnormal_response_to2.05753000
22MP0005275_abnormal_skin_tensile2.02444753
23MP0002723_abnormal_immune_serum2.02415756
24MP0001819_abnormal_immune_cell1.97208405
25MP0002420_abnormal_adaptive_immunity1.97124262
26MP0001873_stomach_inflammation1.93049245
27MP0008004_abnormal_stomach_pH1.82343983
28MP0004264_abnormal_extraembryonic_tissu1.81755627
29MP0001845_abnormal_inflammatory_respons1.73386561
30MP0004782_abnormal_surfactant_physiolog1.72653272
31MP0003279_aneurysm1.72185349
32MP0003866_abnormal_defecation1.69601939
33MP0004947_skin_inflammation1.69340682
34MP0006082_CNS_inflammation1.69284187
35MP0002166_altered_tumor_susceptibility1.60364602
36MP0003075_altered_response_to1.52792221
37MP0003448_altered_tumor_morphology1.50764544
38MP0005023_abnormal_wound_healing1.50031200
39MP0002138_abnormal_hepatobiliary_system1.49994636
40MP0008438_abnormal_cutaneous_collagen1.48821526
41MP0005503_abnormal_tendon_morphology1.46451723
42MP0000343_altered_response_to1.44939180
43MP0001663_abnormal_digestive_system1.44468048
44MP0010352_gastrointestinal_tract_polyps1.44369214
45MP0003191_abnormal_cellular_cholesterol1.42851641
46MP0005464_abnormal_platelet_physiology1.42546867
47MP0005310_abnormal_salivary_gland1.41797934
48MP0002933_joint_inflammation1.41238545
49MP0000716_abnormal_immune_system1.38370528
50MP0002405_respiratory_system_inflammati1.38217480
51MP0004858_abnormal_nervous_system1.36378906
52MP0003763_abnormal_thymus_physiology1.32173320
53MP0002398_abnormal_bone_marrow1.32169107
54MP0003045_fibrosis1.30219423
55MP0009333_abnormal_splenocyte_physiolog1.28363354
56MP0001851_eye_inflammation1.23898124
57MP0005164_abnormal_response_to1.22940256
58MP0003183_abnormal_peptide_metabolism1.22909040
59MP0003828_pulmonary_edema1.22609625
60MP0002998_abnormal_bone_remodeling1.20103138
61MP0000604_amyloidosis1.17035758
62MP0005390_skeleton_phenotype1.16090564
63MP0002006_tumorigenesis1.14913279
64MP0009764_decreased_sensitivity_to1.11844379
65MP0008469_abnormal_protein_level1.11834585
66MP0002429_abnormal_blood_cell1.08051129
67MP0000858_altered_metastatic_potential1.03617546
68MP0005381_digestive/alimentary_phenotyp1.03296689
69MP0009278_abnormal_bone_marrow1.03166062
70MP0000249_abnormal_blood_vessel1.01233080
71MP0002722_abnormal_immune_system1.00411989
72MP0000689_abnormal_spleen_morphology1.00017137
73MP0002277_abnormal_respiratory_mucosa0.94922486
74MP0001542_abnormal_bone_strength0.94666503
75MP0001986_abnormal_taste_sensitivity0.93265356
76MP0002133_abnormal_respiratory_system0.93208082
77MP0005388_respiratory_system_phenotype0.93208082
78MP0003329_amyloid_beta_deposits0.91956759
79MP0000477_abnormal_intestine_morphology0.87134836
80MP0003566_abnormal_cell_adhesion0.87124831
81MP0005165_increased_susceptibility_to0.86949125
82MP0009840_abnormal_foam_cell0.86854316
83MP0001879_abnormal_lymphatic_vessel0.86419569
84MP0000490_abnormal_crypts_of0.85703908
85MP0003091_abnormal_cell_migration0.83706159
86MP0003795_abnormal_bone_structure0.81083700
87MP0003453_abnormal_keratinocyte_physiol0.76567832
88MP0001545_abnormal_hematopoietic_system0.76434730
89MP0005397_hematopoietic_system_phenotyp0.76434730
90MP0010368_abnormal_lymphatic_system0.76055016
91MP0004510_myositis0.75210415
92MP0001664_abnormal_digestion0.73228527
93MP0000681_abnormal_thyroid_gland0.73101184
94MP0008874_decreased_physiological_sensi0.72681883
95MP0008260_abnormal_autophagy0.71903782
96MP0001958_emphysema0.70428038
97MP0002896_abnormal_bone_mineralization0.69307017
98MP0001853_heart_inflammation0.68279460
99MP0006054_spinal_hemorrhage0.66471735
100MP0005085_abnormal_gallbladder_physiolo0.66119014

Predicted human phenotypes

RankGene SetZ-score
1Prostate neoplasm (HP:0100787)9.32461097
2Abnormality of macrophages (HP:0004311)6.69588864
3Abnormality of the prostate (HP:0008775)6.05856039
4Systemic lupus erythematosus (HP:0002725)5.93698375
5Vasculitis (HP:0002633)4.53507858
6Eczematoid dermatitis (HP:0000976)4.47412082
7Leukocytosis (HP:0001974)4.02149299
8Abnormality of cells of the lymphoid lineage (HP:0012140)3.92871924
9Abnormality of complement system (HP:0005339)3.74129228
10Abnormality of male internal genitalia (HP:0000022)3.63211059
11Skin rash (HP:0000988)3.54206086
12Recurrent bronchitis (HP:0002837)3.53945321
13Glomerulonephritis (HP:0000099)3.51843076
14Agammaglobulinemia (HP:0004432)3.48076483
15Complement deficiency (HP:0004431)3.44268364
16Spontaneous hematomas (HP:0007420)3.40458591
17Recurrent abscess formation (HP:0002722)3.38143923
18Recurrent bacterial skin infections (HP:0005406)3.34809684
19Malnutrition (HP:0004395)3.33647815
20Gastrointestinal stroma tumor (HP:0100723)3.22896270
21Meningitis (HP:0001287)3.12767319
22Cellulitis (HP:0100658)3.09796855
23Gastrointestinal infarctions (HP:0005244)3.02569256
24Neoplasm of the lung (HP:0100526)2.98891773
25Urticaria (HP:0001025)2.93365663
26Colitis (HP:0002583)2.91209931
27Myositis (HP:0100614)2.90310981
28Nephritis (HP:0000123)2.89985853
29Osteomyelitis (HP:0002754)2.89151209
30Orchitis (HP:0100796)2.87890293
31Premature loss of primary teeth (HP:0006323)2.87783541
32Abnormal delayed hypersensitivity skin test (HP:0002963)2.84849631
33Inflammation of the large intestine (HP:0002037)2.80023403
34Gingivitis (HP:0000230)2.73299582
35Gastrointestinal inflammation (HP:0004386)2.65976175
36Obstructive lung disease (HP:0006536)2.65755938
37Chronic obstructive pulmonary disease (HP:0006510)2.65755938
38Hemoptysis (HP:0002105)2.59241791
39Abnormality of the nasal mucosa (HP:0000433)2.59041892
40Neoplasm of the respiratory system (HP:0100606)2.58510244
41Abnormality of B cell number (HP:0010975)2.58316123
42Recurrent gram-negative bacterial infections (HP:0005420)2.56221990
43Chronic otitis media (HP:0000389)2.53007656
44Mediastinal lymphadenopathy (HP:0100721)2.52806928
45Elevated erythrocyte sedimentation rate (HP:0003565)2.52115145
46Increased IgE level (HP:0003212)2.50324134
47Hypermelanotic macule (HP:0001034)2.48218315
48Pulmonary infiltrates (HP:0002113)2.45864293
49Optic neuritis (HP:0100653)2.40853205
50Retrobulbar optic neuritis (HP:0100654)2.40853205
51Chronic diarrhea (HP:0002028)2.38989930
52Recurrent viral infections (HP:0004429)2.38139081
53Polycythemia (HP:0001901)2.32183852
54Recurrent sinusitis (HP:0011108)2.31451197
55Recurrent skin infections (HP:0001581)2.31369969
56Emphysema (HP:0002097)2.22977180
57Recurrent fungal infections (HP:0002841)2.22168206
58Peritonitis (HP:0002586)2.17828635
59Gingival bleeding (HP:0000225)2.15341551
60Recurrent pneumonia (HP:0006532)2.15053218
61Hematochezia (HP:0002573)2.14198207
62Bronchitis (HP:0012387)2.13048488
63Chest pain (HP:0100749)2.11314691
64Purpura (HP:0000979)2.10938158
65Interstitial pulmonary disease (HP:0006530)2.10385552
66Ankyloglossia (HP:0010296)2.10200074
67Pustule (HP:0200039)2.08819085
68Abnormality of the peritoneum (HP:0002585)2.07869093
69Abnormality of T cell number (HP:0011839)2.07527640
70Metaphyseal cupping (HP:0003021)2.07312796
71Skin ulcer (HP:0200042)2.06937485
72Right ventricular cardiomyopathy (HP:0011663)2.06375708
73Restrictive lung disease (HP:0002091)2.01688383
74Recurrent cutaneous fungal infections (HP:0011370)2.00692840
75Chronic mucocutaneous candidiasis (HP:0002728)2.00692840
76Hypergammaglobulinemia (HP:0010702)2.00549677
77Autoimmune thrombocytopenia (HP:0001973)1.99576946
78B lymphocytopenia (HP:0010976)1.99397239
79Recurrent lower respiratory tract infections (HP:0002783)1.99199138
80Xerostomia (HP:0000217)1.98898016
81Keratoconjunctivitis sicca (HP:0001097)1.97267412
82Verrucae (HP:0200043)1.96355552
83Papilloma (HP:0012740)1.96355552
84Increased IgM level (HP:0003496)1.95577619
85Periodontitis (HP:0000704)1.95550087
86Alopecia of scalp (HP:0002293)1.92029190
87Epistaxis (HP:0000421)1.88954833
88Villous atrophy (HP:0011473)1.88556428
89Abnormality of small intestinal villus morphology (HP:0011472)1.88556428
90Autoimmune hemolytic anemia (HP:0001890)1.88179800
91Nasal polyposis (HP:0100582)1.87663261
92Lymphopenia (HP:0001888)1.87291163
93Hyperactive renin-angiotensin system (HP:0000841)1.86327029
94Pulmonary embolism (HP:0002204)1.85511587
95Fragile skin (HP:0001030)1.84962624
96Sepsis (HP:0100806)1.84860751
97Abnormality of the pleura (HP:0002103)1.84097540
98T lymphocytopenia (HP:0005403)1.84068042
99Abnormality of monocarboxylic acid metabolism (HP:0010996)1.83495061
100Abnormality of T cell physiology (HP:0011840)1.82485655

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.96644016
2TYK23.34029372
3MAP4K13.14312000
4RIPK42.90119150
5BLK2.83981085
6PRPF4B2.66221045
7FGFR42.50605606
8MST1R2.36015052
9EPHA32.24544764
10EPHB12.15065134
11KIT2.13286139
12RIPK12.08268617
13JAK12.00489273
14JAK31.99696991
15FES1.96925549
16IRAK41.89913643
17CSK1.88419852
18GRK61.85257014
19ZAP701.76319942
20CDC42BPA1.75853366
21TXK1.72636584
22PIK3CA1.63068063
23MAP3K141.62419008
24IKBKE1.60846253
25JAK21.55350183
26FGFR31.50565947
27TGFBR21.44424284
28MAP3K11.38850549
29LYN1.37950600
30SIK31.34186070
31SYK1.32641267
32PKN21.30604515
33MAP3K31.28880234
34IRAK11.27629662
35PDGFRA1.27387369
36TBK11.25137152
37BMPR21.19801295
38MAP2K31.19432825
39BTK1.18420736
40HCK1.15866199
41FER1.12199066
42MATK1.11237375
43CSF1R1.05246286
44YES11.04056516
45NLK1.02761087
46TAOK10.99395551
47MET0.97943153
48DDR20.90850008
49STK240.89803367
50FGR0.83300189
51MAP3K100.81057341
52TGFBR10.80782847
53RET0.79386656
54FLT30.76028493
55LCK0.75537348
56MAP3K130.75488472
57EPHB20.75387479
58TAOK30.69040397
59PTK60.68050465
60PDGFRB0.67199083
61PRKG20.66942397
62KSR20.66536444
63MAP3K60.65287120
64GRK50.65098321
65TEC0.63261915
66FYN0.61615630
67OXSR10.61278359
68PDPK10.60387363
69LRRK20.58622816
70TAOK20.56455694
71IKBKB0.56336307
72MYLK0.55259426
73HIPK20.54869185
74MAPK70.54661683
75ITK0.54442131
76STK390.54235366
77MAP3K20.51793339
78ACVR1B0.50399038
79PDK10.49927599
80CDK60.49496729
81TRIB30.48987684
82IGF1R0.46282382
83IRAK30.45140116
84EPHA20.43024752
85MAP3K110.41254484
86MAP3K120.41203572
87DMPK0.40596409
88MAP3K50.40441284
89IRAK20.37412121
90ABL10.36976085
91CLK10.36477223
92TNK20.35434589
93LMTK20.35391538
94MAPKAPK20.35167121
95PRKCQ0.34747683
96GRK10.34463836
97NEK90.33007579
98MAPK40.32779976
99PRKCD0.32699821
100MAPK110.31839174

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.17407700
2Asthma_Homo sapiens_hsa053103.81177114
3Allograft rejection_Homo sapiens_hsa053303.22357251
4Autoimmune thyroid disease_Homo sapiens_hsa053203.11319383
5Graft-versus-host disease_Homo sapiens_hsa053323.01654083
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.91018312
7Leishmaniasis_Homo sapiens_hsa051402.85093516
8Type I diabetes mellitus_Homo sapiens_hsa049402.47022797
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.34138608
10Antigen processing and presentation_Homo sapiens_hsa046122.20680938
11Viral myocarditis_Homo sapiens_hsa054162.00150486
12Hematopoietic cell lineage_Homo sapiens_hsa046401.90927407
13Malaria_Homo sapiens_hsa051441.83849661
14Osteoclast differentiation_Homo sapiens_hsa043801.82049590
15Rheumatoid arthritis_Homo sapiens_hsa053231.79270566
16Pertussis_Homo sapiens_hsa051331.78854228
17Toxoplasmosis_Homo sapiens_hsa051451.74277461
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.71099691
19Primary immunodeficiency_Homo sapiens_hsa053401.68453588
20B cell receptor signaling pathway_Homo sapiens_hsa046621.62896050
21Tuberculosis_Homo sapiens_hsa051521.61535211
22Influenza A_Homo sapiens_hsa051641.44685944
23Complement and coagulation cascades_Homo sapiens_hsa046101.41160238
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.35673161
25Chemokine signaling pathway_Homo sapiens_hsa040621.34657553
26TNF signaling pathway_Homo sapiens_hsa046681.34569659
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.27186463
28Phagosome_Homo sapiens_hsa041451.23892251
29African trypanosomiasis_Homo sapiens_hsa051431.18374067
30Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.15577163
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.12654587
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.12364213
33Herpes simplex infection_Homo sapiens_hsa051681.11318059
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.01355307
35Other glycan degradation_Homo sapiens_hsa005110.99744633
36Measles_Homo sapiens_hsa051620.99355838
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.95311531
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.94954570
39Cyanoamino acid metabolism_Homo sapiens_hsa004600.90481560
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88815182
41Hepatitis C_Homo sapiens_hsa051600.88212155
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88007085
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87612961
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85824207
45Sulfur metabolism_Homo sapiens_hsa009200.85678339
46Arginine biosynthesis_Homo sapiens_hsa002200.84710515
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84000694
48Amoebiasis_Homo sapiens_hsa051460.79144403
49Renin-angiotensin system_Homo sapiens_hsa046140.78191781
50NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77286323
51Acute myeloid leukemia_Homo sapiens_hsa052210.74475337
52Systemic lupus erythematosus_Homo sapiens_hsa053220.73791600
53Fructose and mannose metabolism_Homo sapiens_hsa000510.70455775
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68534126
55Protein digestion and absorption_Homo sapiens_hsa049740.65690507
56Legionellosis_Homo sapiens_hsa051340.63787922
57Salmonella infection_Homo sapiens_hsa051320.59984357
58Lysosome_Homo sapiens_hsa041420.59778576
59Arachidonic acid metabolism_Homo sapiens_hsa005900.59736916
60Fat digestion and absorption_Homo sapiens_hsa049750.58771107
61Apoptosis_Homo sapiens_hsa042100.57742543
62Prolactin signaling pathway_Homo sapiens_hsa049170.57283743
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55025006
64T cell receptor signaling pathway_Homo sapiens_hsa046600.54799701
65Mineral absorption_Homo sapiens_hsa049780.53765509
66Hepatitis B_Homo sapiens_hsa051610.52532004
67Pancreatic cancer_Homo sapiens_hsa052120.51033569
68Platelet activation_Homo sapiens_hsa046110.49123024
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48679052
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47724900
71Renal cell carcinoma_Homo sapiens_hsa052110.46809363
72Pancreatic secretion_Homo sapiens_hsa049720.46148728
73HTLV-I infection_Homo sapiens_hsa051660.45222831
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42098533
75Chronic myeloid leukemia_Homo sapiens_hsa052200.40218441
76N-Glycan biosynthesis_Homo sapiens_hsa005100.39696413
77HIF-1 signaling pathway_Homo sapiens_hsa040660.39507216
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38903056
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.37667166
80Thyroid hormone synthesis_Homo sapiens_hsa049180.37359168
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35336375
82Shigellosis_Homo sapiens_hsa051310.35082776
83Starch and sucrose metabolism_Homo sapiens_hsa005000.34970220
84VEGF signaling pathway_Homo sapiens_hsa043700.34115552
85Epstein-Barr virus infection_Homo sapiens_hsa051690.33949761
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.33857170
87Prion diseases_Homo sapiens_hsa050200.32561991
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32320383
89Dorso-ventral axis formation_Homo sapiens_hsa043200.29659704
90PPAR signaling pathway_Homo sapiens_hsa033200.29039373
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.28525619
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.28346237
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27850233
94Galactose metabolism_Homo sapiens_hsa000520.27532149
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26589799
96Caffeine metabolism_Homo sapiens_hsa002320.25592330
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.25474614
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.25297694
99GnRH signaling pathway_Homo sapiens_hsa049120.25099246
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.24940131

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