IGKJ1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1humoral immune response (GO:0006959)9.15900466
2positive regulation of respiratory burst (GO:0060267)7.27579447
3glomerular filtration (GO:0003094)6.53212120
4negative regulation of glucose import (GO:0046325)6.19663050
5immune response-activating cell surface receptor signaling pathway (GO:0002429)6.10801474
6signal peptide processing (GO:0006465)5.94345280
7keratinization (GO:0031424)5.87596302
8renal filtration (GO:0097205)5.81706075
9cytidine deamination (GO:0009972)5.49555545
10cytidine metabolic process (GO:0046087)5.49555545
11cytidine catabolic process (GO:0006216)5.49555545
12antigen processing and presentation of endogenous antigen (GO:0019883)5.45389265
13B cell receptor signaling pathway (GO:0050853)5.41378302
14regulation of glucose import in response to insulin stimulus (GO:2001273)5.28401004
15negative regulation of B cell proliferation (GO:0030889)5.12203385
16negative regulation of glucose transport (GO:0010829)5.00374253
17regulation of respiratory burst (GO:0060263)4.89044591
18detection of bacterium (GO:0016045)4.88734625
19detection of other organism (GO:0098543)4.80029983
20Fc-epsilon receptor signaling pathway (GO:0038095)4.68740765
21Fc receptor signaling pathway (GO:0038093)4.68013699
22regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)4.63112991
23cellular response to zinc ion (GO:0071294)4.34355538
24positive regulation of B cell differentiation (GO:0045579)4.32031898
25phenylpropanoid metabolic process (GO:0009698)4.25246963
26immune response-regulating cell surface receptor signaling pathway (GO:0002768)4.23447156
27immunoglobulin mediated immune response (GO:0016064)4.21930879
28regulation of B cell proliferation (GO:0030888)4.13745365
29germinal center formation (GO:0002467)4.01531398
30fucose catabolic process (GO:0019317)4.01395213
31L-fucose metabolic process (GO:0042354)4.01395213
32L-fucose catabolic process (GO:0042355)4.01395213
33pyrimidine ribonucleoside catabolic process (GO:0046133)3.91953010
34regulation of water loss via skin (GO:0033561)3.86975392
35establishment of skin barrier (GO:0061436)3.86594852
36regulation of B cell receptor signaling pathway (GO:0050855)3.83836132
37immune response-activating signal transduction (GO:0002757)3.83405107
38regulation of B cell differentiation (GO:0045577)3.81143891
39antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.72928059
40antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.72928059
41antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.61241665
42proline biosynthetic process (GO:0006561)3.57071321
43positive regulation of macrophage cytokine production (GO:0060907)3.54318297
44detection of external biotic stimulus (GO:0098581)3.50997040
45interferon-gamma-mediated signaling pathway (GO:0060333)3.50753406
46activation of immune response (GO:0002253)3.46861803
47type I interferon signaling pathway (GO:0060337)3.36702089
48cellular response to type I interferon (GO:0071357)3.36702089
49negative thymic T cell selection (GO:0045060)3.36584632
50interferon-gamma secretion (GO:0072643)3.36188616
51response to type I interferon (GO:0034340)3.33654212
52regulation of cellular extravasation (GO:0002691)3.30425346
53response to protozoan (GO:0001562)3.30297489
54regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.27575307
55positive regulation of immunoglobulin production (GO:0002639)3.26312092
56regulation of dendritic cell antigen processing and presentation (GO:0002604)3.25137268
57B cell mediated immunity (GO:0019724)3.24366807
58B cell proliferation (GO:0042100)3.21097788
59surfactant homeostasis (GO:0043129)3.21047652
60negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.19772431
61somatic hypermutation of immunoglobulin genes (GO:0016446)3.19171742
62somatic diversification of immune receptors via somatic mutation (GO:0002566)3.19171742
63ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.15181713
64regulation of antigen processing and presentation (GO:0002577)3.12156461
65bundle of His cell to Purkinje myocyte communication (GO:0086069)3.10039781
66defense response to protozoan (GO:0042832)3.09064772
67chaperone mediated protein folding requiring cofactor (GO:0051085)3.07639061
68negative T cell selection (GO:0043383)3.05421147
69positive regulation of Rho protein signal transduction (GO:0035025)3.02629837
70regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.02476815
71detection of biotic stimulus (GO:0009595)3.01029798
72complement activation, classical pathway (GO:0006958)26.6065779
73complement activation (GO:0006956)20.4074570
74chronic inflammatory response (GO:0002544)2.99195779
75regulation of regulatory T cell differentiation (GO:0045589)2.93610048
76cellular extravasation (GO:0045123)2.92530649
77regulation of T cell tolerance induction (GO:0002664)2.90427497
78positive regulation of antigen processing and presentation (GO:0002579)2.89073290
79negative regulation of B cell activation (GO:0050869)2.87825869
80regulation of B cell apoptotic process (GO:0002902)2.85520688
81negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.85187608
82negative regulation of cell killing (GO:0031342)2.85187608
83regulation of B cell activation (GO:0050864)2.84590999
84regulation of germinal center formation (GO:0002634)2.82493181
85multicellular organismal water homeostasis (GO:0050891)2.80580655
86keratinocyte differentiation (GO:0030216)2.80462914
87regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.79662470
88positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.75697783
89Golgi transport vesicle coating (GO:0048200)2.74967597
90COPI coating of Golgi vesicle (GO:0048205)2.74967597
91mast cell activation (GO:0045576)2.72506654
92tissue homeostasis (GO:0001894)2.70624846
93cellular response to interferon-gamma (GO:0071346)2.69077033
94skin morphogenesis (GO:0043589)2.68074744
95protein N-linked glycosylation via asparagine (GO:0018279)2.67486351
96respiratory burst (GO:0045730)2.67457752
97positive regulation of gamma-delta T cell activation (GO:0046645)2.67203582
98positive regulation of protein homooligomerization (GO:0032464)2.66309656
99positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.66210697
100positive regulation of T cell chemotaxis (GO:0010820)2.63732326
101regulation of T cell chemotaxis (GO:0010819)2.63732326
102positive regulation of tolerance induction (GO:0002645)2.63272024
103peptidyl-asparagine modification (GO:0018196)2.62800052
104production of molecular mediator involved in inflammatory response (GO:0002532)2.62395499
105regulation of tolerance induction (GO:0002643)2.62159824
106positive regulation of granulocyte chemotaxis (GO:0071624)2.60551474
107positive T cell selection (GO:0043368)2.59618812
108response to interleukin-15 (GO:0070672)2.57658636
109production of molecular mediator of immune response (GO:0002440)2.54119257
110peptide cross-linking (GO:0018149)2.52180144
111regulation of integrin activation (GO:0033623)2.51986388
112thymic T cell selection (GO:0045061)2.51933056
113regulation of type I interferon-mediated signaling pathway (GO:0060338)2.51200261
114lipoxygenase pathway (GO:0019372)2.51020014
115negative regulation of cellular response to insulin stimulus (GO:1900077)2.50830888
116water homeostasis (GO:0030104)2.50184573
117T-helper 1 type immune response (GO:0042088)2.50179397
118defense response to Gram-negative bacterium (GO:0050829)2.49967737
119positive regulation of type 2 immune response (GO:0002830)2.49734349
120protein-chromophore linkage (GO:0018298)2.48788857
121purine deoxyribonucleotide catabolic process (GO:0009155)2.48375587
122superoxide anion generation (GO:0042554)2.46704619
123daunorubicin metabolic process (GO:0044597)2.45789669
124polyketide metabolic process (GO:0030638)2.45789669
125doxorubicin metabolic process (GO:0044598)2.45789669
126protein N-linked glycosylation (GO:0006487)2.44926700
127neutrophil activation involved in immune response (GO:0002283)2.44760175
128response to interferon-gamma (GO:0034341)2.44519268
129antibacterial humoral response (GO:0019731)2.44475036
130regulation of gamma-delta T cell activation (GO:0046643)2.42782254
131antigen receptor-mediated signaling pathway (GO:0050851)2.42473361
132positive regulation of T cell migration (GO:2000406)2.41720350
133maternal placenta development (GO:0001893)2.41012406
134negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.40920808
135regulation of macrophage cytokine production (GO:0010935)2.39640917
136regulation of natural killer cell differentiation (GO:0032823)2.38163194
137regulation of immunoglobulin production (GO:0002637)2.36707701
138positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.34696593
139positive regulation of Rap GTPase activity (GO:0032854)2.34106130
140proline metabolic process (GO:0006560)2.33191950
141xenobiotic catabolic process (GO:0042178)2.32631847
142negative regulation of B cell apoptotic process (GO:0002903)2.31477020
143positive regulation of production of molecular mediator of immune response (GO:0002702)2.31093270
144positive regulation of nuclease activity (GO:0032075)2.30263161
145activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.29834957
146antimicrobial humoral response (GO:0019730)2.29146484
147endoplasmic reticulum unfolded protein response (GO:0030968)2.28793231
148regulation of nuclease activity (GO:0032069)2.28431735
149N-acetylneuraminate metabolic process (GO:0006054)2.28252273
150positive thymic T cell selection (GO:0045059)2.28208940
151bone resorption (GO:0045453)2.27500772
152regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.25557310
153cellular response to unfolded protein (GO:0034620)2.24323852
154UDP-N-acetylglucosamine metabolic process (GO:0006047)2.24106025
155B cell homeostasis (GO:0001782)2.22970073
156regulation of interferon-beta biosynthetic process (GO:0045357)2.21893262
157T cell selection (GO:0045058)2.19953011
158regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.14578833
159regulation of gamma-delta T cell differentiation (GO:0045586)2.12289804
160positive regulation of B cell activation (GO:0050871)2.11532901
161gonadal mesoderm development (GO:0007506)13.7156402
162protein activation cascade (GO:0072376)13.2722674
163immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:000211.2296838
164Fc-gamma receptor signaling pathway (GO:0038094)11.2296838
165Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)11.2296838
166Fc receptor mediated stimulatory signaling pathway (GO:0002431)11.0920128
167retina homeostasis (GO:0001895)10.3952862

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.14213542
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.05385108
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.94151732
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.66230312
5IRF8_21731497_ChIP-ChIP_J774_Mouse4.41744716
6SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.88159083
7MYC_22102868_ChIP-Seq_BL_Human3.82946288
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.81023910
9E2F7_22180533_ChIP-Seq_HELA_Human3.74168694
10E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human3.43186440
11TP63_17297297_ChIP-ChIP_HaCaT_Human3.35104984
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.18991992
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.07823927
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.90352778
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.85425628
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.75009110
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.64620976
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.64263927
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.47024424
20MAF_26560356_Chip-Seq_TH1_Human2.35506582
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.34495145
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.33899756
23RUNX_20019798_ChIP-Seq_JUKART_Human2.18682846
24STAT4_19710469_ChIP-ChIP_TH1__Mouse2.13216657
25VDR_21846776_ChIP-Seq_THP-1_Human2.09063576
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.06961025
27MYB_26560356_Chip-Seq_TH2_Human1.99836119
28MYB_26560356_Chip-Seq_TH1_Human1.97722730
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.93207549
30PPARA_22158963_ChIP-Seq_LIVER_Mouse1.89365055
31STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.86679575
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.82834866
33GATA1_22025678_ChIP-Seq_K562_Human1.75812206
34VDR_24763502_ChIP-Seq_THP-1_Human1.74251302
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.73192787
36PU.1_20513432_ChIP-Seq_Bcells_Mouse1.72799022
37NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.69636322
38UTX_26944678_Chip-Seq_JUKART_Human1.65585894
39SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62676875
40SCL_19346495_ChIP-Seq_HPC-7_Human1.62567128
41CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.59883614
42GATA3_26560356_Chip-Seq_TH2_Human1.59883451
43GATA3_27048872_Chip-Seq_THYMUS_Human1.58731228
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55690146
45RXR_22158963_ChIP-Seq_LIVER_Mouse1.55179859
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54721272
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.53486370
48STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.52233662
49NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49388749
50Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.47558591
51SPI1_23547873_ChIP-Seq_NB4_Human1.46054167
52SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.45607899
53DROSHA_22980978_ChIP-Seq_HELA_Human1.45294257
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42771901
55PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42333110
56VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.42041550
57LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.37363506
58RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.35892068
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.35875811
60VDR_24787735_ChIP-Seq_THP-1_Human1.35754183
61MYB_21317192_ChIP-Seq_ERMYB_Mouse1.34673483
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30063708
63VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.29056936
64CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.28880268
65PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.28657044
66KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.26155658
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20463319
68CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.19945365
69CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19417615
70RUNX1_22412390_ChIP-Seq_EML_Mouse1.19235425
71GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19164806
72MAF_26560356_Chip-Seq_TH2_Human1.18183812
73TCF7_22412390_ChIP-Seq_EML_Mouse1.18112721
74PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.17726010
75EGR1_19032775_ChIP-ChIP_M12_Human1.15379470
76TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.13500849
77LXR_22292898_ChIP-Seq_THP-1_Human1.13417664
78THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.12747273
79NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.11842003
80GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09962493
81P63_26484246_Chip-Seq_KERATINOCYTES_Human1.09441179
82MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09366664
83GATA2_21666600_ChIP-Seq_HMVEC_Human1.07918737
84EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07272539
85STAT1_20625510_ChIP-Seq_HELA_Human1.05893009
86ELK3_25401928_ChIP-Seq_HUVEC_Human1.05542905
87SOX2_20726797_ChIP-Seq_SW620_Human1.04891923
88SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04850541
89LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04805246
90HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04338997
91KDM2B_26808549_Chip-Seq_DND41_Human1.04289544
92TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03811446
93CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03012165
94GATA1_19941826_ChIP-Seq_K562_Human1.02784508
95SPI1_23127762_ChIP-Seq_K562_Human1.02736080
96FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00699577
97LXR_22158963_ChIP-Seq_LIVER_Mouse1.00189488
98ESR1_20079471_ChIP-ChIP_T-47D_Human0.98468628
99BP1_19119308_ChIP-ChIP_Hs578T_Human0.97940464
100EST1_17652178_ChIP-ChIP_JURKAT_Human0.97386249
101FOXO3_23340844_ChIP-Seq_DLD1_Human0.96510884
102PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95083317
103GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93811356
104FOXM1_23109430_ChIP-Seq_U2OS_Human0.93494433
105ESR1_21235772_ChIP-Seq_MCF-7_Human0.93194022
106KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92197528
107CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91941064
108SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90254877
109E2F1_17053090_ChIP-ChIP_MCF-7_Human0.88157831
110RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.88125705
111BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.87932886
112TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.87899212
113CREB1_15753290_ChIP-ChIP_HEK293T_Human0.87748777
114ELF1_20517297_ChIP-Seq_JURKAT_Human0.87592850
115CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86807842
116TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.85708817
117KDM2B_26808549_Chip-Seq_SUP-B15_Human0.82943422
118BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82914339
119PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82829468
120SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.82625254
121SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.82625254
122GATA2_19941826_ChIP-Seq_K562_Human0.82591582
123GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81716390
124PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81657967
125ELF1_17652178_ChIP-ChIP_JURKAT_Human0.81130196
126PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81122097
127KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.80482444
128SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79833308
129BCL6_27268052_Chip-Seq_Bcells_Human0.79758955
130ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.78982255
131ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.78852843
132PU_27001747_Chip-Seq_BMDM_Mouse0.78740517
133ERG_20887958_ChIP-Seq_HPC-7_Mouse0.78552397
134GATA1_19941827_ChIP-Seq_MEL_Mouse0.78159210
135GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.77793418
136GATA4_25053715_ChIP-Seq_YYC3_Human0.77348375
137SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.76566050
138BCOR_27268052_Chip-Seq_Bcells_Human0.75040801
139ESR2_21235772_ChIP-Seq_MCF-7_Human0.74964341
140SMRT_27268052_Chip-Seq_Bcells_Human0.74873622
141RUNX1_27514584_Chip-Seq_MCF-7_Human0.73199535
142ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.72665147

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.69891578
2MP0001800_abnormal_humoral_immune4.75674862
3MP0003303_peritoneal_inflammation4.18701489
4MP0003724_increased_susceptibility_to3.96835030
5MP0005671_abnormal_response_to3.70529844
6MP0005387_immune_system_phenotype3.51558506
7MP0001790_abnormal_immune_system3.51558506
8MP0002452_abnormal_antigen_presenting3.38196416
9MP0002796_impaired_skin_barrier2.98576292
10MP0002723_abnormal_immune_serum2.90987555
11MP0002420_abnormal_adaptive_immunity2.75070076
12MP0001819_abnormal_immune_cell2.69239641
13MP0005275_abnormal_skin_tensile2.60267428
14MP0006054_spinal_hemorrhage2.59874854
15MP0000685_abnormal_immune_system2.59263491
16MP0002398_abnormal_bone_marrow2.59165047
17MP0005000_abnormal_immune_tolerance2.56189794
18MP0000716_abnormal_immune_system2.53298690
19MP0002148_abnormal_hypersensitivity_rea2.44528142
20MP0002166_altered_tumor_susceptibility2.42832438
21MP0000689_abnormal_spleen_morphology2.20071388
22MP0010234_abnormal_vibrissa_follicle2.08905113
23MP0005025_abnormal_response_to2.06805748
24MP0002429_abnormal_blood_cell2.06306814
25MP0002139_abnormal_hepatobiliary_system1.89203035
26MP0002006_tumorigenesis1.89033123
27MP0002419_abnormal_innate_immunity1.85590894
28MP0001879_abnormal_lymphatic_vessel1.81052149
29MP0002722_abnormal_immune_system1.80013500
30MP0008438_abnormal_cutaneous_collagen1.79973557
31MP0002138_abnormal_hepatobiliary_system1.77746298
32MP0003191_abnormal_cellular_cholesterol1.77373343
33MP0004947_skin_inflammation1.75641558
34MP0002876_abnormal_thyroid_physiology1.74313421
35MP0005360_urolithiasis1.69927619
36MP0003436_decreased_susceptibility_to1.69231210
37MP0001845_abnormal_inflammatory_respons1.67034954
38MP0009333_abnormal_splenocyte_physiolog1.63437588
39MP0005166_decreased_susceptibility_to1.59783917
40MP0003453_abnormal_keratinocyte_physiol1.58995767
41MP0004782_abnormal_surfactant_physiolog1.58413632
42MP0003300_gastrointestinal_ulcer1.54444827
43MP0005501_abnormal_skin_physiology1.50791674
44MP0003763_abnormal_thymus_physiology1.46470748
45MP0000465_gastrointestinal_hemorrhage1.44893343
46MP0002405_respiratory_system_inflammati1.42303702
47MP0002060_abnormal_skin_morphology1.38100636
48MP0000920_abnormal_myelination1.37952521
49MP0008004_abnormal_stomach_pH1.33988354
50MP0000858_altered_metastatic_potential1.33201086
51MP0009785_altered_susceptibility_to1.32848429
52MP0005310_abnormal_salivary_gland1.31831492
53MP0005085_abnormal_gallbladder_physiolo1.29109206
54MP0002396_abnormal_hematopoietic_system1.27131553
55MP0006082_CNS_inflammation1.27075267
56MP0010155_abnormal_intestine_physiology1.26490747
57MP0003183_abnormal_peptide_metabolism1.25741832
58MP0002933_joint_inflammation1.24067926
59MP0000013_abnormal_adipose_tissue1.23452884
60MP0009046_muscle_twitch1.20942016
61MP0004264_abnormal_extraembryonic_tissu1.18625209
62MP0003045_fibrosis1.16897848
63MP0001851_eye_inflammation1.16655080
64MP0001853_heart_inflammation1.15305966
65MP0004510_myositis1.14651168
66MP0003448_altered_tumor_morphology1.12913259
67MP0004859_abnormal_synaptic_plasticity1.10395616
68MP0001216_abnormal_epidermal_layer1.09982574
69MP0008569_lethality_at_weaning1.09648366
70MP0002019_abnormal_tumor_incidence1.09494106
71MP0003566_abnormal_cell_adhesion1.05949913
72MP0010352_gastrointestinal_tract_polyps1.05436442
73MP0003866_abnormal_defecation1.03870306
74MP0009764_decreased_sensitivity_to1.02974063
75MP0001873_stomach_inflammation1.02900757
76MP0000343_altered_response_to1.02896729
77MP0008057_abnormal_DNA_replication1.02630217
78MP0003279_aneurysm1.02577245
79MP0003075_altered_response_to1.02186652
80MP0005584_abnormal_enzyme/coenzyme_acti1.01222551
81MP0008872_abnormal_physiological_respon0.98073634
82MP0000377_abnormal_hair_follicle0.96714842
83MP0003941_abnormal_skin_development0.96473624
84MP0005464_abnormal_platelet_physiology0.96436198
85MP0004043_abnormal_pH_regulation0.96408738
86MP0000703_abnormal_thymus_morphology0.96307020
87MP0002136_abnormal_kidney_physiology0.92464144
88MP0002098_abnormal_vibrissa_morphology0.92235292
89MP0001348_abnormal_lacrimal_gland0.90779105
90MP0010771_integument_phenotype0.89962943
91MP0010678_abnormal_skin_adnexa0.88312191
92MP0000579_abnormal_nail_morphology0.87615354
93MP0005332_abnormal_amino_acid0.87521825
94MP0003186_abnormal_redox_activity0.86927852
95MP0001919_abnormal_reproductive_system0.86838677
96MP0005164_abnormal_response_to0.86586215
97MP0001545_abnormal_hematopoietic_system0.84601722
98MP0005397_hematopoietic_system_phenotyp0.84601722
99MP0008469_abnormal_protein_level0.84417223
100MP0002998_abnormal_bone_remodeling0.83163519
101MP0000609_abnormal_liver_physiology0.82620009
102MP0009931_abnormal_skin_appearance0.82239238
103MP0003690_abnormal_glial_cell0.81981718
104MP0000003_abnormal_adipose_tissue0.81729366
105MP0003656_abnormal_erythrocyte_physiolo0.81487992
106MP0005623_abnormal_meninges_morphology0.80765639
107MP0008875_abnormal_xenobiotic_pharmacok0.78958629
108MP0000249_abnormal_blood_vessel0.78093681
109MP0002877_abnormal_melanocyte_morpholog0.78083432
110MP0003828_pulmonary_edema0.77998315
111MP0005381_digestive/alimentary_phenotyp0.77860833
112MP0005390_skeleton_phenotype0.77793089
113MP0002277_abnormal_respiratory_mucosa0.77432167
114MP0000490_abnormal_crypts_of0.76297501
115MP0005451_abnormal_body_composition0.75965218
116MP0009643_abnormal_urine_homeostasis0.74693097
117MP0003879_abnormal_hair_cell0.74146045
118MP0003795_abnormal_bone_structure0.73777778
119MP0003252_abnormal_bile_duct0.72583217
120MP0001666_abnormal_nutrient_absorption0.71641995
121MP0009278_abnormal_bone_marrow0.70729636
122MP0002133_abnormal_respiratory_system0.69514763
123MP0005388_respiratory_system_phenotype0.69514763
124MP0002083_premature_death0.68660651
125MP0004858_abnormal_nervous_system0.68179560
126MP0001191_abnormal_skin_condition0.67385073
127MP0001986_abnormal_taste_sensitivity0.67283411
128MP0008260_abnormal_autophagy0.67210185
129MP0005083_abnormal_biliary_tract0.65984808
130MP0003091_abnormal_cell_migration0.64486227
131MP0004381_abnormal_hair_follicle0.63325986
132MP0010329_abnormal_lipoprotein_level0.62892048
133MP0001663_abnormal_digestive_system0.62398853
134MP0004147_increased_porphyrin_level0.61401455
135MP0009840_abnormal_foam_cell0.60934237
136MP0000604_amyloidosis0.60835441
137MP0003880_abnormal_central_pattern0.60658932
138MP0009763_increased_sensitivity_to0.60310597
139MP0002254_reproductive_system_inflammat0.59926280
140MP0005023_abnormal_wound_healing0.58095292
141MP0005365_abnormal_bile_salt0.57426461
142MP0001958_emphysema0.55326536
143MP0002693_abnormal_pancreas_physiology0.54720252
144MP0001533_abnormal_skeleton_physiology0.54386161
145MP0008873_increased_physiological_sensi0.52963913
146MP0003806_abnormal_nucleotide_metabolis0.52244581
147MP0005058_abnormal_lysosome_morphology0.51717592

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)9.27088124
2Prostate neoplasm (HP:0100787)8.17002836
3B lymphocytopenia (HP:0010976)8.09415479
4Abnormality of B cell number (HP:0010975)8.09415479
5Recurrent bronchitis (HP:0002837)6.80288128
6Recurrent sinusitis (HP:0011108)6.64302918
7Cellulitis (HP:0100658)6.16325922
8Gastrointestinal stroma tumor (HP:0100723)5.67485714
9Verrucae (HP:0200043)5.66220858
10Papilloma (HP:0012740)5.66220858
11Abnormality of macrophages (HP:0004311)5.38696967
12Abnormality of nail color (HP:0100643)5.33990581
13Abnormality of the prostate (HP:0008775)5.28474924
14Colitis (HP:0002583)5.28274783
15IgM deficiency (HP:0002850)5.04440284
16Recurrent pneumonia (HP:0006532)4.89148359
17Increased IgE level (HP:0003212)4.81069712
18Recurrent viral infections (HP:0004429)4.79512819
19Meningitis (HP:0001287)4.69404147
20Chronic sinusitis (HP:0011109)4.49280802
21Recurrent lower respiratory tract infections (HP:0002783)4.21214990
22Thyroiditis (HP:0100646)4.05374506
23IgG deficiency (HP:0004315)4.01057765
24Chronic otitis media (HP:0000389)3.94166843
25Bronchitis (HP:0012387)3.83240532
26Osteomyelitis (HP:0002754)3.78554129
27Recurrent otitis media (HP:0000403)3.74925612
28Inflammation of the large intestine (HP:0002037)3.70892092
29Gastrointestinal inflammation (HP:0004386)3.56889138
30IgA deficiency (HP:0002720)3.56131625
31Panhypogammaglobulinemia (HP:0003139)3.53158019
32Sepsis (HP:0100806)3.43306520
33Alopecia of scalp (HP:0002293)3.37032078
34Systemic lupus erythematosus (HP:0002725)3.32874936
35Right ventricular cardiomyopathy (HP:0011663)3.26034074
36Emphysema (HP:0002097)3.24551527
37Onycholysis (HP:0001806)3.22204150
38Abnormality of T cell physiology (HP:0011840)3.21003994
39Skin rash (HP:0000988)3.13167046
40Abnormality of T cell number (HP:0011839)3.05290002
41Abnormality of male internal genitalia (HP:0000022)2.99565206
42Autoimmune thrombocytopenia (HP:0001973)2.95994415
43Vasculitis (HP:0002633)2.95656881
44Abnormality of T cells (HP:0002843)2.87343730
45Elevated erythrocyte sedimentation rate (HP:0003565)2.78751632
46Gangrene (HP:0100758)2.77045127
47Hypoplasia of the thymus (HP:0000778)2.76823418
48Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.74910091
49Congenital ichthyosiform erythroderma (HP:0007431)2.73642487
50Restrictive lung disease (HP:0002091)2.72597036
51Abnormality of cells of the lymphoid lineage (HP:0012140)2.72475031
52Lymphopenia (HP:0001888)2.70023816
53Interstitial pulmonary disease (HP:0006530)2.69584459
54T lymphocytopenia (HP:0005403)2.69156163
55Persistence of primary teeth (HP:0006335)2.61377514
56Combined immunodeficiency (HP:0005387)2.59582717
57Recurrent fungal infections (HP:0002841)2.57352692
58Erythema (HP:0010783)2.55307416
59Abnormal delayed hypersensitivity skin test (HP:0002963)2.54196422
60Palmoplantar hyperkeratosis (HP:0000972)2.52460225
61Recurrent abscess formation (HP:0002722)2.50589460
62Obstructive lung disease (HP:0006536)2.48725140
63Chronic obstructive pulmonary disease (HP:0006510)2.48725140
64Spontaneous hematomas (HP:0007420)2.48090441
65Severe combined immunodeficiency (HP:0004430)2.47916761
66Mitral stenosis (HP:0001718)2.46392367
67Corneal erosion (HP:0200020)2.45909269
68Hyperactive renin-angiotensin system (HP:0000841)2.42613954
69Neoplasm of the lung (HP:0100526)2.42499362
70Gastrointestinal infarctions (HP:0005244)2.42408820
71Hypermelanotic macule (HP:0001034)2.42219759
72Recurrent bacterial skin infections (HP:0005406)2.37199454
73Vacuolated lymphocytes (HP:0001922)2.35994635
74Palmar hyperkeratosis (HP:0010765)2.33192834
75Pustule (HP:0200039)2.25592077
76Mucosal telangiectasiae (HP:0100579)2.19830068
77Plantar hyperkeratosis (HP:0007556)2.17636951
78Thick nail (HP:0001805)2.16337973
79Orchitis (HP:0100796)2.14927854
80Hypotrichosis (HP:0001006)2.13551936
81Hemoptysis (HP:0002105)2.13049804
82Skin ulcer (HP:0200042)2.12656651
83Glomerulonephritis (HP:0000099)2.12555323
84Neoplasm of the respiratory system (HP:0100606)2.10749232
85Eosinophilia (HP:0001880)2.10416336
86Xerostomia (HP:0000217)2.09349888
87Pruritus (HP:0000989)2.08113315
88Neutropenia (HP:0001875)2.06117542
89Chronic mucocutaneous candidiasis (HP:0002728)2.05790695
90Recurrent cutaneous fungal infections (HP:0011370)2.05790695
91Acrocyanosis (HP:0001063)2.05656166
92Recurrent skin infections (HP:0001581)2.03327982
93Oral leukoplakia (HP:0002745)2.01913009
94Premature loss of primary teeth (HP:0006323)1.99903386
95Recurrent gram-negative bacterial infections (HP:0005420)1.97850988
96Colon cancer (HP:0003003)1.97481202
97Pulmonary infiltrates (HP:0002113)1.97453801
98Myositis (HP:0100614)1.96435335
99Optic neuritis (HP:0100653)1.93428856
100Retrobulbar optic neuritis (HP:0100654)1.93428856
101Ectropion (HP:0000656)1.93374154
102Gingivitis (HP:0000230)1.92422171
103Deep venous thrombosis (HP:0002625)1.92158331
104Nephritis (HP:0000123)1.91625794
105Hypertensive crisis (HP:0100735)1.90350462
106Limb hypertonia (HP:0002509)1.89768832
107Abnormality of complement system (HP:0005339)1.89581221
108Malnutrition (HP:0004395)1.88642846
109Arthralgia (HP:0002829)1.86152740
110Lymphoma (HP:0002665)1.84673307
111Nonimmune hydrops fetalis (HP:0001790)1.84411731
112Abnormality of the intrinsic pathway (HP:0010989)1.84241585
113Nasal polyposis (HP:0100582)1.81641862
114Pili torti (HP:0003777)1.81282070
115Leukopenia (HP:0001882)1.79411632
116Hypoproteinemia (HP:0003075)1.79397581
117Blepharitis (HP:0000498)1.78598668
118Thrombocytosis (HP:0001894)1.70146040
119Hypergammaglobulinemia (HP:0010702)1.69432458
120Papilledema (HP:0001085)1.68408018
121Eczematoid dermatitis (HP:0000976)1.66920718
122Bronchiectasis (HP:0002110)1.65569991
123Conjunctival hamartoma (HP:0100780)1.65488057
124Acute encephalopathy (HP:0006846)1.65380180
125Abnormality of eosinophils (HP:0001879)1.65299058
126Progressive macrocephaly (HP:0004481)1.64147890
127Abnormality of the nasal mucosa (HP:0000433)1.62324183
128Teleangiectasia of the skin (HP:0100585)1.60631585
129Keratoconjunctivitis sicca (HP:0001097)1.60366573
130Acute necrotizing encephalopathy (HP:0006965)1.56507333
131Dehydration (HP:0001944)1.54587016
132Abnormal gallbladder morphology (HP:0012437)1.53821522
133Macroorchidism (HP:0000053)1.52738676
134Mediastinal lymphadenopathy (HP:0100721)1.52676793
135Cholelithiasis (HP:0001081)1.50995422
136Leukocytosis (HP:0001974)1.50184671
137Autoimmune hemolytic anemia (HP:0001890)1.49429251
138Dysostosis multiplex (HP:0000943)1.49074524
139Keratoconjunctivitis (HP:0001096)1.48795978
140Urticaria (HP:0001025)1.48653921
141Granulocytopenia (HP:0001913)1.44203789
142Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.44149661
143Stomatitis (HP:0010280)1.43055830
144Multiple enchondromatosis (HP:0005701)1.41906510
145Abnormality of monocarboxylic acid metabolism (HP:0010996)1.41146745
146Hyperventilation (HP:0002883)1.41099573
147Viral hepatitis (HP:0006562)1.40567803

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK27.26032547
2ERN15.38261999
3MAP4K15.11336657
4RIPK43.07695449
5SYK2.89000469
6GRK62.66026111
7GRK12.53386691
8KIT2.51041343
9PRKCH2.41803119
10CSF1R2.33045085
11BUB12.24199792
12TYK22.20214268
13TXK2.10163149
14BLK2.09115697
15PRPF4B2.07108137
16SIK22.02584466
17LYN2.01260081
18SIK31.99608802
19MAP3K141.92178713
20TAOK31.87865395
21BCKDK1.85813323
22MST1R1.84295110
23BTK1.82838811
24PKN21.80063340
25ZAP701.79904165
26EIF2AK31.79274851
27NME21.75858817
28MAP3K101.74884612
29MAP3K131.68175643
30TBK11.61638958
31IRAK41.59484089
32ITK1.57252682
33FES1.53856972
34FLT31.52472969
35CLK11.45671880
36PIK3CA1.40565305
37PIK3CG1.38348064
38PRKCQ1.37642042
39MST41.36472707
40NEK21.36074094
41MAP3K41.23583598
42IRAK31.21818357
43IRAK11.20264817
44JAK11.19673590
45HCK1.19130581
46FGFR31.14099830
47FRK1.12269264
48MET1.10687855
49EPHA31.08887155
50STK101.08240538
51MAPKAPK31.03312327
52MAP3K11.02783354
53FGFR21.02636300
54BMX1.02445178
55PRKCI1.02423181
56RIPK10.99293054
57HIPK20.98734535
58SIK10.97359460
59STK240.94864201
60LCK0.94579802
61PIM10.92460889
62KDR0.89893752
63FGFR40.87987553
64NEK10.85794145
65IKBKB0.84332204
66EPHB10.82212562
67TTN0.78967855
68MAP3K90.78888303
69MAP3K30.78085421
70TAOK10.77787883
71UHMK10.77526248
72CSNK1G30.77474035
73IKBKE0.76867644
74FYN0.76219079
75BMPR20.75221524
76TEC0.74936463
77LRRK20.74075950
78MATK0.73971383
79MAP3K60.73110881
80PRKCD0.72937951
81PRKD10.72360732
82BRSK10.72073231
83NEK90.71129928
84CSNK1A1L0.70473230
85TGFBR20.69462917
86KSR20.68174355
87MAP2K30.68068466
88DDR20.67342720
89PDGFRA0.67208677
90CSK0.66258344
91PKN10.65275843
92ALK0.63170779
93RET0.62028163
94CSNK1G20.61727752
95IGF1R0.61540411
96JAK30.59808888
97TAOK20.57616689
98BCR0.56597899
99GRK50.53611612
100MAPK120.53222737
101FGR0.51778605
102FER0.46212842
103MAPK40.45177417
104CSNK1G10.42583918
105NME10.40374819
106PDPK10.40108006
107JAK20.39262024
108PDGFRB0.39210307
109MAP3K110.38595263
110RPS6KA60.38418828
111INSR0.37316445
112IRAK20.37240166
113MAPK70.35351606
114TRIB30.34274178
115ABL10.33749356
116YES10.33558682
117MAPKAPK20.33153674
118EEF2K0.32780950
119RPS6KC10.32740756
120RPS6KL10.32740756
121ACVR1B0.32608236
122PRKCZ0.32122678
123CDC42BPA0.31427948
124NTRK10.31406211
125TAF10.31189388
126PDK10.31169299
127CDK150.30858285
128MARK30.30427546
129PDK20.30230300
130NTRK30.28878966
131EIF2AK20.28308344
132CCNB10.28281116
133ARAF0.28218229
134TGFBR10.28137283
135EGFR0.27724676
136EPHA20.27228280
137MAP3K80.25091929
138CDK180.24870360
139MAPK110.23853933
140RPS6KB20.23013652
141CDK50.21064459
142VRK10.20592963
143CAMKK10.20506621
144SRC0.20190809

Predicted pathways (KEGG)

RankGene SetZ-score
1Intestinal immune network for IgA production_Homo sapiens_hsa046729.08251862
2Primary immunodeficiency_Homo sapiens_hsa053405.80533086
3Protein export_Homo sapiens_hsa030604.38604900
4B cell receptor signaling pathway_Homo sapiens_hsa046623.69300468
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.50158024
6N-Glycan biosynthesis_Homo sapiens_hsa005102.34003515
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.11191594
8Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.93301004
9Rheumatoid arthritis_Homo sapiens_hsa053231.84560656
10DNA replication_Homo sapiens_hsa030301.65078931
11Asthma_Homo sapiens_hsa053101.63545496
12Influenza A_Homo sapiens_hsa051641.54624774
13Proteasome_Homo sapiens_hsa030501.50593794
14Antigen processing and presentation_Homo sapiens_hsa046121.44834805
15Allograft rejection_Homo sapiens_hsa053301.31966336
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.31195477
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.29855555
18Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.29717280
19Non-homologous end-joining_Homo sapiens_hsa034501.28867651
20Phagosome_Homo sapiens_hsa041451.28322136
21Leishmaniasis_Homo sapiens_hsa051401.25717353
22TNF signaling pathway_Homo sapiens_hsa046681.21117333
23Base excision repair_Homo sapiens_hsa034101.20317415
24Herpes simplex infection_Homo sapiens_hsa051681.20117486
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.19714614
26Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.19638719
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.17538613
28Mismatch repair_Homo sapiens_hsa034301.09278330
29Folate biosynthesis_Homo sapiens_hsa007901.06161807
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05983568
31Other glycan degradation_Homo sapiens_hsa005111.03167546
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.00672286
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98302141
34Primary bile acid biosynthesis_Homo sapiens_hsa001200.97057588
35Osteoclast differentiation_Homo sapiens_hsa043800.96386007
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94646402
37Staphylococcus aureus infection_Homo sapiens_hsa051500.91936393
38Hepatitis C_Homo sapiens_hsa051600.91800159
39T cell receptor signaling pathway_Homo sapiens_hsa046600.91065143
40Arginine biosynthesis_Homo sapiens_hsa002200.85942442
41Acute myeloid leukemia_Homo sapiens_hsa052210.85286264
42Homologous recombination_Homo sapiens_hsa034400.85211478
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84340238
44Pyruvate metabolism_Homo sapiens_hsa006200.83532959
45Nitrogen metabolism_Homo sapiens_hsa009100.82980305
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.81872048
47Viral myocarditis_Homo sapiens_hsa054160.81801435
48Tuberculosis_Homo sapiens_hsa051520.81434956
49Malaria_Homo sapiens_hsa051440.80548808
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76870695
51Pertussis_Homo sapiens_hsa051330.76250114
52NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76179680
53Phenylalanine metabolism_Homo sapiens_hsa003600.72831334
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72053223
55Tryptophan metabolism_Homo sapiens_hsa003800.71572249
56Arachidonic acid metabolism_Homo sapiens_hsa005900.70710854
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70688937
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68048715
59Ether lipid metabolism_Homo sapiens_hsa005650.67360447
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67028503
61Type I diabetes mellitus_Homo sapiens_hsa049400.65631098
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65116623
63Chemokine signaling pathway_Homo sapiens_hsa040620.64480385
64Long-term potentiation_Homo sapiens_hsa047200.62917216
65Systemic lupus erythematosus_Homo sapiens_hsa053220.62181618
66Amphetamine addiction_Homo sapiens_hsa050310.60774997
67Amoebiasis_Homo sapiens_hsa051460.60443363
68Alzheimers disease_Homo sapiens_hsa050100.59081217
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59015608
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58728435
71Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58382718
72Pancreatic cancer_Homo sapiens_hsa052120.58064569
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.57991386
74Autoimmune thyroid disease_Homo sapiens_hsa053200.57493886
75Phototransduction_Homo sapiens_hsa047440.56777101
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56320984
77Lysosome_Homo sapiens_hsa041420.55711888
78Linoleic acid metabolism_Homo sapiens_hsa005910.54993071
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54024567
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53843905
81Graft-versus-host disease_Homo sapiens_hsa053320.53687852
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53407714
83Renal cell carcinoma_Homo sapiens_hsa052110.53059511
84Salmonella infection_Homo sapiens_hsa051320.49843579
85Hematopoietic cell lineage_Homo sapiens_hsa046400.49683336
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49115873
87Fatty acid degradation_Homo sapiens_hsa000710.48987124
88Prolactin signaling pathway_Homo sapiens_hsa049170.48766892
89Dorso-ventral axis formation_Homo sapiens_hsa043200.47640943
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46834400
91Complement and coagulation cascades_Homo sapiens_hsa046100.45909587
92African trypanosomiasis_Homo sapiens_hsa051430.45168123
93GnRH signaling pathway_Homo sapiens_hsa049120.42606939
94Chronic myeloid leukemia_Homo sapiens_hsa052200.40462059
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40125008
96Biosynthesis of amino acids_Homo sapiens_hsa012300.40045542
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38937505
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38335157
99Histidine metabolism_Homo sapiens_hsa003400.38043340
100Vibrio cholerae infection_Homo sapiens_hsa051100.36628998
101HIF-1 signaling pathway_Homo sapiens_hsa040660.36501156
102Shigellosis_Homo sapiens_hsa051310.36287792
103Thyroid hormone synthesis_Homo sapiens_hsa049180.34140049
104Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.34057942
105Sulfur metabolism_Homo sapiens_hsa009200.33509255
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.31319693
107Legionellosis_Homo sapiens_hsa051340.30635270
108Non-small cell lung cancer_Homo sapiens_hsa052230.30573105
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.30554672
110Toll-like receptor signaling pathway_Homo sapiens_hsa046200.30115499
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29993250
112Renin secretion_Homo sapiens_hsa049240.29809834
113Choline metabolism in cancer_Homo sapiens_hsa052310.28912101
114Measles_Homo sapiens_hsa051620.28107744
115beta-Alanine metabolism_Homo sapiens_hsa004100.27815464
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.27672656
117Toxoplasmosis_Homo sapiens_hsa051450.27581315
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27535548
119Fatty acid metabolism_Homo sapiens_hsa012120.27256449
120Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.26627980
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25999087
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25286837
123Circadian entrainment_Homo sapiens_hsa047130.25212070
124Small cell lung cancer_Homo sapiens_hsa052220.25206282
125Glioma_Homo sapiens_hsa052140.25053587
126Ribosome_Homo sapiens_hsa030100.24928666
127VEGF signaling pathway_Homo sapiens_hsa043700.24892498
128Type II diabetes mellitus_Homo sapiens_hsa049300.24333689
129Pancreatic secretion_Homo sapiens_hsa049720.24198854
130SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23797844
131Hepatitis B_Homo sapiens_hsa051610.23155996
132Phosphatidylinositol signaling system_Homo sapiens_hsa040700.22305349
133Peroxisome_Homo sapiens_hsa041460.22220068
134Glycosaminoglycan degradation_Homo sapiens_hsa005310.22133461
135Carbohydrate digestion and absorption_Homo sapiens_hsa049730.21870867
136Insulin resistance_Homo sapiens_hsa049310.21488872
137Sphingolipid signaling pathway_Homo sapiens_hsa040710.20902730
138Epstein-Barr virus infection_Homo sapiens_hsa051690.20578198
139One carbon pool by folate_Homo sapiens_hsa006700.20108890
140Neurotrophin signaling pathway_Homo sapiens_hsa047220.18569168
141Viral carcinogenesis_Homo sapiens_hsa052030.18110247
142Fatty acid elongation_Homo sapiens_hsa000620.17637994
143Platelet activation_Homo sapiens_hsa046110.17521375
144HTLV-I infection_Homo sapiens_hsa051660.16849860
145RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.16783560
146Cocaine addiction_Homo sapiens_hsa050300.16753451
147Apoptosis_Homo sapiens_hsa042100.16094284
148Carbon metabolism_Homo sapiens_hsa012000.15520964

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