IGHV5-51

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1complement activation (GO:0006956)8.46351813
2positive regulation of respiratory burst (GO:0060267)7.48387587
3glomerular filtration (GO:0003094)6.65955940
4protein activation cascade (GO:0072376)6.22834537
5renal filtration (GO:0097205)6.03683944
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.99051376
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.97006065
8antigen processing and presentation of endogenous antigen (GO:0019883)5.64889337
9immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00025.45341407
10Fc-gamma receptor signaling pathway (GO:0038094)5.45341407
11Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)5.45341407
12Fc receptor mediated stimulatory signaling pathway (GO:0002431)5.41774894
13regulation of respiratory burst (GO:0060263)5.04330411
14humoral immune response (GO:0006959)4.93966923
15detection of bacterium (GO:0016045)4.45442547
16antimicrobial humoral response (GO:0019730)4.38864414
17detection of other organism (GO:0098543)4.34436894
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.32496025
19antibacterial humoral response (GO:0019731)4.30141176
20interferon-gamma-mediated signaling pathway (GO:0060333)3.95442818
21negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.90762273
22negative regulation of cell killing (GO:0031342)3.90762273
23cellular response to type I interferon (GO:0071357)3.90629971
24type I interferon signaling pathway (GO:0060337)3.90629971
25response to type I interferon (GO:0034340)3.88872351
26immunoglobulin mediated immune response (GO:0016064)3.83697844
27retina homeostasis (GO:0001895)3.70518129
28germinal center formation (GO:0002467)3.68745686
29regulation of cellular extravasation (GO:0002691)3.62431253
30immune response-activating cell surface receptor signaling pathway (GO:0002429)3.53791065
31positive regulation of gamma-delta T cell activation (GO:0046645)3.49523329
32regulation of dendritic cell antigen processing and presentation (GO:0002604)3.43442279
33regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.24811450
34detection of external biotic stimulus (GO:0098581)3.23599958
35positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.19412542
36cellular response to interferon-gamma (GO:0071346)3.18761253
37regulation of antigen processing and presentation (GO:0002577)3.18423528
38response to interferon-gamma (GO:0034341)2.97532373
39positive regulation of antigen processing and presentation (GO:0002579)2.96233190
40positive regulation of Cdc42 GTPase activity (GO:0043089)2.95324162
41surfactant homeostasis (GO:0043129)2.94518580
42B cell mediated immunity (GO:0019724)2.92164575
43myeloid dendritic cell differentiation (GO:0043011)2.91750362
44negative regulation of myotube differentiation (GO:0010832)2.87236543
45positive regulation by symbiont of host defense response (GO:0052509)2.87223963
46modulation by symbiont of host defense response (GO:0052031)2.87223963
47modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.87223963
48modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.87223963
49positive regulation by organism of defense response of other organism involved in symbiotic interact2.87223963
50modulation by symbiont of host immune response (GO:0052553)2.87223963
51NIK/NF-kappaB signaling (GO:0038061)2.85356393
52immune response-activating signal transduction (GO:0002757)2.80497177
53regulation of B cell receptor signaling pathway (GO:0050855)2.80038113
54T-helper 1 type immune response (GO:0042088)2.79609177
55establishment of skin barrier (GO:0061436)2.76041364
56production of molecular mediator of immune response (GO:0002440)2.75957810
57detection of biotic stimulus (GO:0009595)2.74730413
58activation of immune response (GO:0002253)2.73572092
59regulation of water loss via skin (GO:0033561)2.72408361
60chronic inflammatory response (GO:0002544)2.71765252
61regulation of type I interferon-mediated signaling pathway (GO:0060338)2.70859579
62myeloid dendritic cell activation (GO:0001773)2.70585235
63regulation of gamma-delta T cell activation (GO:0046643)2.65417929
64B cell receptor signaling pathway (GO:0050853)2.64999901
65regulation of T cell tolerance induction (GO:0002664)2.64425176
66regulation of integrin activation (GO:0033623)2.62489975
67interferon-gamma secretion (GO:0072643)2.58772189
68dendritic cell chemotaxis (GO:0002407)2.56004444
69macrophage activation involved in immune response (GO:0002281)2.51270333
70keratinization (GO:0031424)2.49743361
71T cell costimulation (GO:0031295)2.49433492
72lymphocyte costimulation (GO:0031294)2.45597324
73regulation of interferon-beta biosynthetic process (GO:0045357)2.45007060
74negative regulation of bone resorption (GO:0045779)2.44859940
75respiratory burst (GO:0045730)2.43613114
76regulation of regulatory T cell differentiation (GO:0045589)2.42752450
77defense response to protozoan (GO:0042832)2.42513146
78regulation of tolerance induction (GO:0002643)2.41619414
79defense response to Gram-negative bacterium (GO:0050829)2.41292070
80bundle of His cell to Purkinje myocyte communication (GO:0086069)2.39833624
81negative regulation of humoral immune response (GO:0002921)2.38534176
82antigen processing and presentation via MHC class Ib (GO:0002475)2.38119187
83positive regulation of T cell migration (GO:2000406)2.36862737
84positive regulation of pseudopodium assembly (GO:0031274)2.36522115
85positive thymic T cell selection (GO:0045059)2.35090625
86adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.34503680
87negative regulation of complement activation (GO:0045916)2.33794106
88negative regulation of innate immune response (GO:0045824)2.31825014
89regulation of gamma-delta T cell differentiation (GO:0045586)2.31486034
90CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.31368345
91positive regulation of B cell differentiation (GO:0045579)2.31219421
92multicellular organismal water homeostasis (GO:0050891)2.30851612
93cellular extravasation (GO:0045123)2.30306157
94response to interferon-beta (GO:0035456)2.30191651
95regulation of T cell migration (GO:2000404)2.29923122
96regulation of necrotic cell death (GO:0010939)2.29753957
97adhesion of symbiont to host cell (GO:0044650)2.29517954
98virion attachment to host cell (GO:0019062)2.29517954
99response to interleukin-15 (GO:0070672)2.28873519
100complement activation, classical pathway (GO:0006958)10.6716958

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.80571065
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.88224866
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.67341818
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.65083156
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.25606062
6RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.23278882
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.92533857
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.82440132
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.50467550
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.47760462
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.39752065
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.25956300
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.19975926
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.14918526
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.11850609
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.07448812
17EGR1_19374776_ChIP-ChIP_THP-1_Human1.95290325
18MYB_21317192_ChIP-Seq_ERMYB_Mouse1.91219006
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.89753106
20SMAD_19615063_ChIP-ChIP_OVARY_Human1.85355022
21CDX2_20551321_ChIP-Seq_CACO-2_Human1.83893481
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.82145110
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.81827999
24STAT4_19710469_ChIP-ChIP_TH1__Mouse1.80541306
25TRIM28_21343339_ChIP-Seq_HEK293_Human1.76880519
26RUNX_20019798_ChIP-Seq_JUKART_Human1.72181954
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.69875708
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.69388352
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.67823996
30VDR_24763502_ChIP-Seq_THP-1_Human1.63310300
31SOX2_27498859_Chip-Seq_STOMACH_Mouse1.62060851
32CLOCK_20551151_ChIP-Seq_293T_Human1.61531233
33MYB_26560356_Chip-Seq_TH2_Human1.56731836
34BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.53662399
35MYC_22102868_ChIP-Seq_BL_Human1.52838005
36FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.52326802
37VDR_21846776_ChIP-Seq_THP-1_Human1.51523103
38Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.50265968
39MAF_26560356_Chip-Seq_TH1_Human1.46844444
40SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.42014028
41LXR_22292898_ChIP-Seq_THP-1_Human1.40330485
42SOX2_20726797_ChIP-Seq_SW620_Human1.39810494
43KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38934055
44TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35603898
45TCF7_22412390_ChIP-Seq_EML_Mouse1.33640768
46MYB_26560356_Chip-Seq_TH1_Human1.32575211
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32260986
48FOXO3_23340844_ChIP-Seq_DLD1_Human1.32104948
49SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.31931185
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.29491409
51SPI1_23547873_ChIP-Seq_NB4_Human1.27618814
52P63_26484246_Chip-Seq_KERATINOCYTES_Human1.25938033
53SPI1_23127762_ChIP-Seq_K562_Human1.24123816
54FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23205087
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.22003844
56ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.20881172
57KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20664239
58VDR_24787735_ChIP-Seq_THP-1_Human1.20535479
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.16940108
60RARG_19884340_ChIP-ChIP_MEFs_Mouse1.16727389
61UTX_26944678_Chip-Seq_JUKART_Human1.16389867
62GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16167724
63EGR1_19032775_ChIP-ChIP_M12_Human1.16077752
64CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15871506
65NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.15403467
66ESR2_21235772_ChIP-Seq_MCF-7_Human1.15374849
67GATA2_21666600_ChIP-Seq_HMVEC_Human1.12551050
68GATA1_19941826_ChIP-Seq_K562_Human1.12342674
69CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10575500
70ESR1_21235772_ChIP-Seq_MCF-7_Human1.07934289
71KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04847275
72GATA4_25053715_ChIP-Seq_YYC3_Human1.04732486
73RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.04096297
74CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03937358
75SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03703050
76SCL_19346495_ChIP-Seq_HPC-7_Human1.02409042
77RACK7_27058665_Chip-Seq_MCF-7_Human1.00602119
78PPARA_22158963_ChIP-Seq_LIVER_Mouse0.99366482
79RXR_22158963_ChIP-Seq_LIVER_Mouse0.98672965
80KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98113745
81GATA6_25053715_ChIP-Seq_YYC3_Human0.96227806
82GATA1_22025678_ChIP-Seq_K562_Human0.96017710
83TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95496301
84PPAR_26484153_Chip-Seq_NCI-H1993_Human0.94984244
85GATA3_27048872_Chip-Seq_THYMUS_Human0.94652889
86LXR_22158963_ChIP-Seq_LIVER_Mouse0.94628778
87GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94082557
88PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92086958
89SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.90990094
90SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.90990094
91GATA2_19941826_ChIP-Seq_K562_Human0.88833040
92GATA1_19941827_ChIP-Seq_MEL_Mouse0.87676331
93ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.87343779
94TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.86547865
95PU_27001747_Chip-Seq_BMDM_Mouse0.85899391
96TCF4_18268006_ChIP-ChIP_LS174T_Human0.84529740
97KDM2B_26808549_Chip-Seq_DND41_Human0.83593479
98LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.80891107
99PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78852282
100RUNX1_27514584_Chip-Seq_MCF-7_Human0.78777540

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.22843045
2MP0003303_peritoneal_inflammation3.60296737
3MP0001835_abnormal_antigen_presentation3.25883868
4MP0010234_abnormal_vibrissa_follicle3.13969427
5MP0003436_decreased_susceptibility_to3.13583198
6MP0001790_abnormal_immune_system2.99775682
7MP0005387_immune_system_phenotype2.99775682
8MP0000685_abnormal_immune_system2.73580867
9MP0001800_abnormal_humoral_immune2.70946142
10MP0010155_abnormal_intestine_physiology2.67506211
11MP0005275_abnormal_skin_tensile2.65577360
12MP0005025_abnormal_response_to2.46285799
13MP0005671_abnormal_response_to2.43904712
14MP0009785_altered_susceptibility_to2.40243136
15MP0005000_abnormal_immune_tolerance2.32888186
16MP0003300_gastrointestinal_ulcer2.27443590
17MP0004264_abnormal_extraembryonic_tissu2.20756229
18MP0002452_abnormal_antigen_presenting2.13517575
19MP0000465_gastrointestinal_hemorrhage2.01224044
20MP0004947_skin_inflammation2.01198630
21MP0002723_abnormal_immune_serum2.00268262
22MP0002796_impaired_skin_barrier1.99597380
23MP0004782_abnormal_surfactant_physiolog1.97573510
24MP0002148_abnormal_hypersensitivity_rea1.95999925
25MP0001533_abnormal_skeleton_physiology1.95954797
26MP0002419_abnormal_innate_immunity1.93604236
27MP0002138_abnormal_hepatobiliary_system1.93549606
28MP0002166_altered_tumor_susceptibility1.90909805
29MP0001819_abnormal_immune_cell1.89338300
30MP0002420_abnormal_adaptive_immunity1.88330761
31MP0005166_decreased_susceptibility_to1.84762491
32MP0010352_gastrointestinal_tract_polyps1.84062082
33MP0003866_abnormal_defecation1.81632618
34MP0001873_stomach_inflammation1.71496632
35MP0008438_abnormal_cutaneous_collagen1.70683067
36MP0003763_abnormal_thymus_physiology1.70022316
37MP0001845_abnormal_inflammatory_respons1.62836724
38MP0006082_CNS_inflammation1.58849285
39MP0003191_abnormal_cellular_cholesterol1.48621084
40MP0002006_tumorigenesis1.44739598
41MP0009333_abnormal_splenocyte_physiolog1.44432192
42MP0004858_abnormal_nervous_system1.40177724
43MP0000716_abnormal_immune_system1.39303712
44MP0005023_abnormal_wound_healing1.37666497
45MP0003448_altered_tumor_morphology1.36781808
46MP0003453_abnormal_keratinocyte_physiol1.35538879
47MP0002398_abnormal_bone_marrow1.32589956
48MP0008004_abnormal_stomach_pH1.31052725
49MP0000858_altered_metastatic_potential1.29692333
50MP0003075_altered_response_to1.28192940
51MP0005310_abnormal_salivary_gland1.27534325
52MP0003183_abnormal_peptide_metabolism1.25738687
53MP0003045_fibrosis1.24499424
54MP0005464_abnormal_platelet_physiology1.23779746
55MP0001663_abnormal_digestive_system1.23093731
56MP0002998_abnormal_bone_remodeling1.21563304
57MP0002405_respiratory_system_inflammati1.20705061
58MP0005503_abnormal_tendon_morphology1.19208971
59MP0000343_altered_response_to1.17443966
60MP0003566_abnormal_cell_adhesion1.10228719
61MP0002429_abnormal_blood_cell1.08895924
62MP0001851_eye_inflammation1.08024373
63MP0000604_amyloidosis1.05773247
64MP0003828_pulmonary_edema1.05427593
65MP0001216_abnormal_epidermal_layer1.05421193
66MP0008469_abnormal_protein_level1.05082138
67MP0002933_joint_inflammation1.04785310
68MP0002139_abnormal_hepatobiliary_system1.02745829
69MP0005164_abnormal_response_to1.02601814
70MP0005390_skeleton_phenotype1.02127034
71MP0003279_aneurysm1.02002892
72MP0010678_abnormal_skin_adnexa1.01404077
73MP0000477_abnormal_intestine_morphology0.98173007
74MP0002722_abnormal_immune_system0.97878024
75MP0000490_abnormal_crypts_of0.96879172
76MP0000689_abnormal_spleen_morphology0.95842187
77MP0002060_abnormal_skin_morphology0.95820948
78MP0009840_abnormal_foam_cell0.92277989
79MP0009764_decreased_sensitivity_to0.91180621
80MP0005381_digestive/alimentary_phenotyp0.88692528
81MP0000249_abnormal_blood_vessel0.88540372
82MP0003329_amyloid_beta_deposits0.86467047
83MP0003091_abnormal_cell_migration0.86349176
84MP0005451_abnormal_body_composition0.85285772
85MP0005501_abnormal_skin_physiology0.83142508
86MP0002277_abnormal_respiratory_mucosa0.82688966
87MP0003868_abnormal_feces_composition0.79160479
88MP0000579_abnormal_nail_morphology0.78209228
89MP0009278_abnormal_bone_marrow0.77806408
90MP0003795_abnormal_bone_structure0.77769224
91MP0002133_abnormal_respiratory_system0.77546073
92MP0005388_respiratory_system_phenotype0.77546073
93MP0005409_darkened_coat_color0.76205961
94MP0008260_abnormal_autophagy0.75633418
95MP0004510_myositis0.74498200
96MP0009931_abnormal_skin_appearance0.73496831
97MP0005165_increased_susceptibility_to0.72953624
98MP0001666_abnormal_nutrient_absorption0.72143547
99MP0001664_abnormal_digestion0.67978723
100MP0002136_abnormal_kidney_physiology0.67263898

Predicted human phenotypes

RankGene SetZ-score
1Prostate neoplasm (HP:0100787)5.68542617
2Systemic lupus erythematosus (HP:0002725)5.39339524
3Abnormality of macrophages (HP:0004311)4.79546841
4Eczematoid dermatitis (HP:0000976)4.45576854
5Increased IgE level (HP:0003212)4.19081259
6Abnormality of the prostate (HP:0008775)3.97843106
7Vasculitis (HP:0002633)3.90227916
8Alopecia of scalp (HP:0002293)3.75172766
9Abnormality of complement system (HP:0005339)3.62819022
10Recurrent bronchitis (HP:0002837)3.55573516
11Gastrointestinal stroma tumor (HP:0100723)3.55355519
12Malnutrition (HP:0004395)3.45553864
13Agammaglobulinemia (HP:0004432)3.45509455
14Glomerulonephritis (HP:0000099)3.38596517
15Complement deficiency (HP:0004431)3.31019878
16Recurrent bacterial skin infections (HP:0005406)3.28100663
17Abnormality of cells of the lymphoid lineage (HP:0012140)3.18860865
18Premature loss of primary teeth (HP:0006323)3.18827273
19Colitis (HP:0002583)3.11974493
20Gastrointestinal infarctions (HP:0005244)3.07179715
21Meningitis (HP:0001287)3.05128404
22Spontaneous hematomas (HP:0007420)3.00367499
23Urticaria (HP:0001025)2.98409330
24Abnormal delayed hypersensitivity skin test (HP:0002963)2.96291790
25Cellulitis (HP:0100658)2.94376288
26Right ventricular cardiomyopathy (HP:0011663)2.92803186
27Recurrent abscess formation (HP:0002722)2.88411170
28Inflammation of the large intestine (HP:0002037)2.88279523
29Leukocytosis (HP:0001974)2.87543899
30Abnormality of nail color (HP:0100643)2.85467272
31Skin rash (HP:0000988)2.85320653
32Nephritis (HP:0000123)2.83064914
33Gingivitis (HP:0000230)2.77556664
34Gastrointestinal inflammation (HP:0004386)2.75799032
35Thick nail (HP:0001805)2.68502015
36Hyperactive renin-angiotensin system (HP:0000841)2.67551095
37Recurrent viral infections (HP:0004429)2.64977980
38Osteomyelitis (HP:0002754)2.64910037
39Myositis (HP:0100614)2.62402597
40Emphysema (HP:0002097)2.58391083
41Chronic otitis media (HP:0000389)2.56461940
42Abnormality of B cell number (HP:0010975)2.55548281
43Orchitis (HP:0100796)2.55180892
44Pustule (HP:0200039)2.53204271
45Hypergammaglobulinemia (HP:0010702)2.50713360
46Abnormality of the nasal mucosa (HP:0000433)2.49547284
47Mediastinal lymphadenopathy (HP:0100721)2.48736794
48Recurrent sinusitis (HP:0011108)2.45437498
49Hemoptysis (HP:0002105)2.44672696
50Xerostomia (HP:0000217)2.43457401
51Chronic diarrhea (HP:0002028)2.43234449
52Palmoplantar hyperkeratosis (HP:0000972)2.39470870
53Onycholysis (HP:0001806)2.38130149
54Interstitial pulmonary disease (HP:0006530)2.35978646
55Abnormality of male internal genitalia (HP:0000022)2.33851237
56Pulmonary infiltrates (HP:0002113)2.32545963
57Recurrent skin infections (HP:0001581)2.31560933
58Skin ulcer (HP:0200042)2.30129383
59Abnormality of small intestinal villus morphology (HP:0011472)2.29607323
60Villous atrophy (HP:0011473)2.29607323
61Recurrent gram-negative bacterial infections (HP:0005420)2.29160023
62Recurrent fungal infections (HP:0002841)2.27461379
63Plantar hyperkeratosis (HP:0007556)2.26307886
64Elevated erythrocyte sedimentation rate (HP:0003565)2.25745545
65Palmar hyperkeratosis (HP:0010765)2.21300546
66Bronchitis (HP:0012387)2.20524001
67Chronic obstructive pulmonary disease (HP:0006510)2.17733885
68Obstructive lung disease (HP:0006536)2.17733885
69Autoimmune hemolytic anemia (HP:0001890)2.14826073
70Metaphyseal cupping (HP:0003021)2.13821038
71Hypermelanotic macule (HP:0001034)2.13382224
72Neoplasm of the lung (HP:0100526)2.12108584
73Periodontitis (HP:0000704)2.12079959
74Keratoconjunctivitis sicca (HP:0001097)2.11950306
75Optic neuritis (HP:0100653)2.11263432
76Retrobulbar optic neuritis (HP:0100654)2.11263432
77Abnormality of monocarboxylic acid metabolism (HP:0010996)2.10772322
78Fragile skin (HP:0001030)2.09942176
79Chronic mucocutaneous candidiasis (HP:0002728)2.07673015
80Recurrent cutaneous fungal infections (HP:0011370)2.07673015
81Recurrent pneumonia (HP:0006532)2.06082620
82Restrictive lung disease (HP:0002091)2.04942436
83Atrophic scars (HP:0001075)2.04643086
84Papilloma (HP:0012740)2.04264813
85Verrucae (HP:0200043)2.04264813
86B lymphocytopenia (HP:0010976)2.04011157
87Erythema (HP:0010783)2.03861670
88Abnormal hair laboratory examination (HP:0003328)2.02450309
89Ankyloglossia (HP:0010296)1.99665175
90Abnormality of T cell physiology (HP:0011840)1.99511458
91Nasal polyposis (HP:0100582)1.99024021
92Increased IgM level (HP:0003496)1.98974227
93Recurrent lower respiratory tract infections (HP:0002783)1.98360131
94Autoimmune thrombocytopenia (HP:0001973)1.96638704
95Gangrene (HP:0100758)1.95738654
96Abnormality of T cell number (HP:0011839)1.94124378
97Lymphopenia (HP:0001888)1.91968874
98Sepsis (HP:0100806)1.91684991
99Chest pain (HP:0100749)1.90886570
100Ridged nail (HP:0001807)1.89507477

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.47431602
2TYK23.45435475
3MAP4K13.42540226
4PRPF4B3.25813131
5FGFR43.11561990
6RIPK43.04165918
7MST1R2.94901368
8BLK2.67894578
9EPHA32.39098873
10RIPK12.37076277
11JAK12.25770471
12MAP3K142.19524939
13EPHB12.10094353
14KIT2.05482290
15FGFR31.97995540
16CDC42BPA1.90305381
17IKBKE1.89394319
18JAK31.84743867
19TBK11.61047219
20IRAK41.57153205
21CSK1.54617427
22ZAP701.53476425
23PIK3CA1.51858865
24STK241.44365144
25GRK61.38179565
26FES1.35537942
27EPHA21.32028371
28MAP3K131.28643717
29SIK31.28333379
30JAK21.27629117
31TXK1.25625319
32MAP3K11.24314395
33SYK1.21337113
34LYN1.19148936
35IRAK11.14609629
36PDGFRA1.14369752
37TGFBR11.14024128
38CSF1R1.13869051
39MAP3K101.04470900
40MATK1.04409399
41TRIB31.03767771
42FER1.02576848
43BMPR21.02062317
44MAP3K30.96025592
45BTK0.93222049
46HCK0.91504596
47YES10.90141580
48MET0.89657805
49SMG10.87849790
50TAOK10.87523299
51IKBKB0.86634512
52NLK0.86523845
53DDR20.85572656
54PKN20.83869968
55MAPK70.81968659
56FGR0.81040088
57PTK60.78376025
58RET0.72534129
59LCK0.72097169
60TGFBR20.71577588
61MAP3K60.70664312
62TAOK30.69615398
63NEK90.68126608
64MAP2K30.67871833
65HIPK20.64660959
66ACVR1B0.62571156
67LRRK20.61811193
68PRKG20.61470139
69DMPK0.60444104
70EIF2AK30.56922386
71FYN0.56832661
72PDPK10.55310280
73CDK60.55151095
74EPHB20.54687092
75KSR20.52192211
76PDGFRB0.49670212
77MAPKAPK20.49519258
78MAP3K20.49414952
79PDK10.48385553
80MAPK110.48256556
81IRAK30.47895442
82LMTK20.46485414
83ITK0.43661056
84PAK40.42545764
85MYLK0.41026110
86PRKD20.38680795
87TAOK20.37872740
88PRKCQ0.35918249
89MAPK40.32970490
90PRKCD0.31407927
91TEC0.31239050
92MAPK120.30618683
93ABL10.30490813
94IGF1R0.29123351
95TNK20.27027751
96SIK20.25559996
97SRC0.25048109
98MAP3K50.22901748
99CHUK0.22868604
100MAP3K110.22120305

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.72225017
2Asthma_Homo sapiens_hsa053103.36126327
3Allograft rejection_Homo sapiens_hsa053303.33130103
4Autoimmune thyroid disease_Homo sapiens_hsa053203.20591571
5Graft-versus-host disease_Homo sapiens_hsa053323.08536563
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.01086751
7Leishmaniasis_Homo sapiens_hsa051402.69719606
8Type I diabetes mellitus_Homo sapiens_hsa049402.53367454
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.31744494
10Antigen processing and presentation_Homo sapiens_hsa046122.22989908
11Viral myocarditis_Homo sapiens_hsa054162.01597209
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.98116953
13Primary immunodeficiency_Homo sapiens_hsa053401.90147286
14Toxoplasmosis_Homo sapiens_hsa051451.76999454
15Osteoclast differentiation_Homo sapiens_hsa043801.71077351
16Influenza A_Homo sapiens_hsa051641.65998241
17B cell receptor signaling pathway_Homo sapiens_hsa046621.65309596
18Pertussis_Homo sapiens_hsa051331.63379521
19Tuberculosis_Homo sapiens_hsa051521.56553114
20Hematopoietic cell lineage_Homo sapiens_hsa046401.49458459
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.41491502
22Rheumatoid arthritis_Homo sapiens_hsa053231.35021550
23Herpes simplex infection_Homo sapiens_hsa051681.32699681
24Measles_Homo sapiens_hsa051621.27553006
25TNF signaling pathway_Homo sapiens_hsa046681.22301609
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.22201863
27Malaria_Homo sapiens_hsa051441.21667459
28Hepatitis C_Homo sapiens_hsa051601.18822980
29Other glycan degradation_Homo sapiens_hsa005111.17219844
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.17079443
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.15045960
32Phagosome_Homo sapiens_hsa041451.14982051
33Complement and coagulation cascades_Homo sapiens_hsa046101.14204473
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.08727114
35Chemokine signaling pathway_Homo sapiens_hsa040621.08492150
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.07261058
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04336520
38Arginine biosynthesis_Homo sapiens_hsa002200.94069708
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93851641
40African trypanosomiasis_Homo sapiens_hsa051430.93390248
41Jak-STAT signaling pathway_Homo sapiens_hsa046300.92774290
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89659302
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89072549
44Amoebiasis_Homo sapiens_hsa051460.87767260
45Acute myeloid leukemia_Homo sapiens_hsa052210.87367282
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87285376
47Sulfur metabolism_Homo sapiens_hsa009200.79495105
48Renin-angiotensin system_Homo sapiens_hsa046140.79037907
49NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78140506
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77463329
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74973192
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72622385
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.72277669
54Apoptosis_Homo sapiens_hsa042100.71627795
55Protein digestion and absorption_Homo sapiens_hsa049740.70974961
56Fructose and mannose metabolism_Homo sapiens_hsa000510.68092467
57Hepatitis B_Homo sapiens_hsa051610.67858826
58Pancreatic cancer_Homo sapiens_hsa052120.67031280
59T cell receptor signaling pathway_Homo sapiens_hsa046600.65677171
60Salmonella infection_Homo sapiens_hsa051320.58624088
61Platelet activation_Homo sapiens_hsa046110.58490479
62Prolactin signaling pathway_Homo sapiens_hsa049170.58197233
63Systemic lupus erythematosus_Homo sapiens_hsa053220.57423633
64Arachidonic acid metabolism_Homo sapiens_hsa005900.57320773
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55860430
66Mineral absorption_Homo sapiens_hsa049780.55038877
67Legionellosis_Homo sapiens_hsa051340.54886339
68Pancreatic secretion_Homo sapiens_hsa049720.54545719
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53488179
70Fat digestion and absorption_Homo sapiens_hsa049750.51774941
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51468249
72HTLV-I infection_Homo sapiens_hsa051660.50491636
73HIF-1 signaling pathway_Homo sapiens_hsa040660.49700982
74VEGF signaling pathway_Homo sapiens_hsa043700.49568116
75Renal cell carcinoma_Homo sapiens_hsa052110.49449330
76Epstein-Barr virus infection_Homo sapiens_hsa051690.47786024
77Chronic myeloid leukemia_Homo sapiens_hsa052200.47157035
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46379615
79GnRH signaling pathway_Homo sapiens_hsa049120.46078100
80Prion diseases_Homo sapiens_hsa050200.44969181
81Lysosome_Homo sapiens_hsa041420.44445953
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42580363
83Shigellosis_Homo sapiens_hsa051310.41890249
84Histidine metabolism_Homo sapiens_hsa003400.41052995
85Small cell lung cancer_Homo sapiens_hsa052220.40889522
86Thyroid hormone synthesis_Homo sapiens_hsa049180.38882740
87Caffeine metabolism_Homo sapiens_hsa002320.38256823
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.34960862
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.34636421
90Linoleic acid metabolism_Homo sapiens_hsa005910.34148191
91Ether lipid metabolism_Homo sapiens_hsa005650.33919387
92Nitrogen metabolism_Homo sapiens_hsa009100.31754971
93Choline metabolism in cancer_Homo sapiens_hsa052310.31524459
94Starch and sucrose metabolism_Homo sapiens_hsa005000.30673593
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.29644100
96Endocytosis_Homo sapiens_hsa041440.28960104
97Viral carcinogenesis_Homo sapiens_hsa052030.28178258
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.28092742
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27865819
100Non-small cell lung cancer_Homo sapiens_hsa052230.27817328

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