IGHV3-30

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of glucose import in response to insulin stimulus (GO:2001273)8.38770771
2complement activation (GO:0006956)8.22619812
3negative regulation of glucose import (GO:0046325)7.46421090
4positive regulation of respiratory burst (GO:0060267)6.95902814
5negative regulation of glucose transport (GO:0010829)6.56831620
6glomerular filtration (GO:0003094)5.95437203
7protein activation cascade (GO:0072376)5.95212053
8regulation of respiratory burst (GO:0060263)5.51375038
9renal filtration (GO:0097205)5.36298392
10regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022355.34912956
11humoral immune response (GO:0006959)5.06289281
12GDP-mannose metabolic process (GO:0019673)4.92267992
13interleukin-6-mediated signaling pathway (GO:0070102)4.87985567
14Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)4.82608584
15immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00024.82608584
16Fc-gamma receptor signaling pathway (GO:0038094)4.82608584
17Fc receptor mediated stimulatory signaling pathway (GO:0002431)4.79284771
18antigen processing and presentation of endogenous antigen (GO:0019883)4.77527411
19regulation of cellular extravasation (GO:0002691)4.75836371
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.68640668
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.62443355
22mannose metabolic process (GO:0006013)4.62233290
23NIK/NF-kappaB signaling (GO:0038061)4.51743553
24ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.15874135
25antibacterial humoral response (GO:0019731)4.13860144
26antimicrobial humoral response (GO:0019730)4.10523279
27cellular response to ethanol (GO:0071361)4.03211558
28protein maturation by protein folding (GO:0022417)3.99029057
29retina homeostasis (GO:0001895)3.97004423
30embryonic process involved in female pregnancy (GO:0060136)3.77842723
31immunoglobulin mediated immune response (GO:0016064)3.77326844
32positive regulation of gamma-delta T cell activation (GO:0046645)3.70763718
33ER overload response (GO:0006983)3.56652464
34B cell receptor signaling pathway (GO:0050853)3.52869491
35regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.51272932
36negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.38747679
37negative regulation of cell killing (GO:0031342)3.38747679
38negative regulation of cellular response to insulin stimulus (GO:1900077)3.38098894
39signal peptide processing (GO:0006465)3.37898327
40immune response-activating cell surface receptor signaling pathway (GO:0002429)3.34977193
41regulation of dendritic cell antigen processing and presentation (GO:0002604)3.34315364
42regulation of antigen processing and presentation (GO:0002577)3.31564044
43regulation of T cell migration (GO:2000404)3.29539433
44labyrinthine layer development (GO:0060711)3.27695688
45interferon-gamma-mediated signaling pathway (GO:0060333)3.23886888
46respiratory burst (GO:0045730)3.17431574
47type I interferon signaling pathway (GO:0060337)3.17406324
48cellular response to type I interferon (GO:0071357)3.17406324
49response to type I interferon (GO:0034340)3.14083876
50regulation of B cell proliferation (GO:0030888)3.07278623
51post-embryonic morphogenesis (GO:0009886)3.04635569
52antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.03089361
53positive regulation of antigen processing and presentation (GO:0002579)3.02469844
54germinal center formation (GO:0002467)3.00082229
55negative regulation of glycogen biosynthetic process (GO:0045719)2.97346308
56nucleotide-sugar biosynthetic process (GO:0009226)2.95318622
57B cell mediated immunity (GO:0019724)2.93706492
58cellular extravasation (GO:0045123)2.93517589
59negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.88973265
60endoplasmic reticulum unfolded protein response (GO:0030968)2.84659156
61positive regulation of immunoglobulin production (GO:0002639)2.84206386
62positive regulation of phosphatase activity (GO:0010922)2.81266910
63activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.81061595
64positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.78802698
65interferon-gamma secretion (GO:0072643)2.76953086
66cellular response to unfolded protein (GO:0034620)2.75790615
67positive thymic T cell selection (GO:0045059)2.74623037
68regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.72700680
69regulation of gamma-delta T cell activation (GO:0046643)2.72086161
70negative regulation of bone resorption (GO:0045779)2.69960865
71regulation of MHC class I biosynthetic process (GO:0045343)2.69133943
72detection of bacterium (GO:0016045)2.68006845
73positive regulation of B cell differentiation (GO:0045579)2.67920096
74detection of other organism (GO:0098543)2.66381552
75positive regulation of nuclease activity (GO:0032075)2.66100300
76regulation of lymphocyte migration (GO:2000401)2.63699186
77positive regulation of T cell migration (GO:2000406)2.61880387
78regulation of T cell mediated cytotoxicity (GO:0001914)2.61184139
79B cell proliferation (GO:0042100)2.60939673
80tyrosine phosphorylation of STAT protein (GO:0007260)2.60697196
81regulation of energy homeostasis (GO:2000505)2.59753493
82B cell homeostasis (GO:0001782)2.59698100
83regulation of B cell receptor signaling pathway (GO:0050855)2.57919018
84immune response-activating signal transduction (GO:0002757)2.57810343
85regulation of B cell differentiation (GO:0045577)2.56882062
86T cell homeostasis (GO:0043029)2.53910972
87cellular response to topologically incorrect protein (GO:0035967)2.53664477
88ER-nucleus signaling pathway (GO:0006984)2.52450921
89activation of immune response (GO:0002253)2.51675919
90glycosphingolipid catabolic process (GO:0046479)2.50881139
91positive regulation of Rap GTPase activity (GO:0032854)2.50729290
92cellular response to interferon-gamma (GO:0071346)2.50230910
93positive T cell selection (GO:0043368)2.47823441
94detection of external biotic stimulus (GO:0098581)2.47712353
95skin morphogenesis (GO:0043589)2.47234348
96regulation of nuclease activity (GO:0032069)2.46716286
97lymph node development (GO:0048535)2.46513680
98natural killer cell activation involved in immune response (GO:0002323)2.46035018
99positive regulation of interleukin-1 production (GO:0032732)2.45881236
100complement activation, classical pathway (GO:0006958)10.3888671

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.74222548
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.22197165
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.12970344
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.90712816
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.68708557
6RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.30402220
7IRF8_27001747_Chip-Seq_BMDM_Mouse2.94220698
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.78759589
9E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.41632759
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.31828851
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.20186416
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.13448871
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.12275422
14GATA1_22025678_ChIP-Seq_K562_Human2.09935153
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.09365273
16SMAD_19615063_ChIP-ChIP_OVARY_Human2.08352115
17CDX2_20551321_ChIP-Seq_CACO-2_Human2.02721375
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.93199163
19MYB_26560356_Chip-Seq_TH2_Human1.88894971
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.86723375
21MYB_21317192_ChIP-Seq_ERMYB_Mouse1.83615031
22BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.82222771
23NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.76904725
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.73557128
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.72456885
26RUNX_20019798_ChIP-Seq_JUKART_Human1.68573267
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.66429625
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.65846358
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.54916831
30GATA3_27048872_Chip-Seq_THYMUS_Human1.53416076
31SPI1_23547873_ChIP-Seq_NB4_Human1.52851988
32ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.52557653
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.52205237
34CLOCK_20551151_ChIP-Seq_293T_Human1.46017221
35SOX2_27498859_Chip-Seq_STOMACH_Mouse1.44268106
36STAT4_19710469_ChIP-ChIP_TH1__Mouse1.43993647
37CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43769719
38GATA3_26560356_Chip-Seq_TH2_Human1.40874858
39SCL_19346495_ChIP-Seq_HPC-7_Human1.40094785
40MYC_22102868_ChIP-Seq_BL_Human1.37467466
41GATA2_22383799_ChIP-Seq_G1ME_Mouse1.35518801
42Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.32610005
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.30414187
44MYB_26560356_Chip-Seq_TH1_Human1.29578117
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.28917986
46VDR_24763502_ChIP-Seq_THP-1_Human1.28865793
47CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.28275436
48VDR_24787735_ChIP-Seq_THP-1_Human1.22378693
49PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.20394540
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.19600578
51TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.19187567
52FOXO3_23340844_ChIP-Seq_DLD1_Human1.16263712
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.15046457
54LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.13957972
55LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13745758
56TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12597850
57SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.11358829
58PU.1_20513432_ChIP-Seq_Bcells_Mouse1.10777325
59PPARA_22158963_ChIP-Seq_LIVER_Mouse1.08629170
60BRD4_27068464_Chip-Seq_AML-cells_Mouse1.06655857
61CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05071255
62GATA4_25053715_ChIP-Seq_YYC3_Human1.03780657
63SPI1_23127762_ChIP-Seq_K562_Human1.03058270
64SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02344321
65MAF_26560356_Chip-Seq_TH1_Human1.02135056
66GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01935077
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01200446
68SOX2_20726797_ChIP-Seq_SW620_Human0.99869391
69EGR1_19374776_ChIP-ChIP_THP-1_Human0.98476274
70ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98442330
71UTX_26944678_Chip-Seq_JUKART_Human0.98402470
72CEBPB_22108803_ChIP-Seq_LS180_Human0.96766226
73EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96166079
74PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94810751
75GATA2_21666600_ChIP-Seq_HMVEC_Human0.93446774
76ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93119180
77CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91853584
78FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90666937
79ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89870848
80PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89113660
81SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.85490745
82LXR_22158963_ChIP-Seq_LIVER_Mouse0.85336076
83CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.84659544
84RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.83878583
85NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.83460706
86RXR_22158963_ChIP-Seq_LIVER_Mouse0.83272701
87P63_26484246_Chip-Seq_KERATINOCYTES_Human0.80239905
88CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80230008
89KDM2B_26808549_Chip-Seq_SUP-B15_Human0.79895516
90STAT1_20625510_ChIP-Seq_HELA_Human0.76951167
91PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76466635
92CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74380613
93TRIM28_21343339_ChIP-Seq_HEK293_Human0.72557224
94IKZF1_21737484_ChIP-ChIP_HCT116_Human0.72244892
95MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.72233501
96PU_27001747_Chip-Seq_BMDM_Mouse0.72112377
97EGR1_19032775_ChIP-ChIP_M12_Human0.72054316
98GATA2_19941826_ChIP-Seq_K562_Human0.71674445
99GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.71216939
100SMRT_27268052_Chip-Seq_Bcells_Human0.71199334

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.86314444
2MP0003303_peritoneal_inflammation3.63329351
3MP0010234_abnormal_vibrissa_follicle3.27945448
4MP0001835_abnormal_antigen_presentation3.27875372
5MP0001800_abnormal_humoral_immune3.08202528
6MP0005671_abnormal_response_to2.92886913
7MP0005387_immune_system_phenotype2.78108724
8MP0001790_abnormal_immune_system2.78108724
9MP0003436_decreased_susceptibility_to2.76409590
10MP0000685_abnormal_immune_system2.72905513
11MP0002148_abnormal_hypersensitivity_rea2.45566129
12MP0010155_abnormal_intestine_physiology2.42547542
13MP0005000_abnormal_immune_tolerance2.39806966
14MP0002452_abnormal_antigen_presenting2.36478644
15MP0005025_abnormal_response_to2.34367206
16MP0002138_abnormal_hepatobiliary_system2.28053054
17MP0002723_abnormal_immune_serum2.15043690
18MP0009785_altered_susceptibility_to2.11606698
19MP0000015_abnormal_ear_pigmentation2.05163308
20MP0001819_abnormal_immune_cell2.02299904
21MP0002420_abnormal_adaptive_immunity2.01897241
22MP0001873_stomach_inflammation1.99807886
23MP0002419_abnormal_innate_immunity1.97761906
24MP0003656_abnormal_erythrocyte_physiolo1.93510731
25MP0008438_abnormal_cutaneous_collagen1.91891696
26MP0001533_abnormal_skeleton_physiology1.88001530
27MP0000465_gastrointestinal_hemorrhage1.84403905
28MP0005464_abnormal_platelet_physiology1.84087957
29MP0002277_abnormal_respiratory_mucosa1.73712597
30MP0008260_abnormal_autophagy1.73394687
31MP0001845_abnormal_inflammatory_respons1.72619313
32MP0003866_abnormal_defecation1.67515024
33MP0002254_reproductive_system_inflammat1.65472857
34MP0004782_abnormal_surfactant_physiolog1.64465368
35MP0003045_fibrosis1.61813919
36MP0005166_decreased_susceptibility_to1.52966278
37MP0003300_gastrointestinal_ulcer1.52822234
38MP0002398_abnormal_bone_marrow1.50932417
39MP0005275_abnormal_skin_tensile1.50791344
40MP0000716_abnormal_immune_system1.50581110
41MP0004264_abnormal_extraembryonic_tissu1.46318823
42MP0004947_skin_inflammation1.43487323
43MP0003075_altered_response_to1.38279253
44MP0005310_abnormal_salivary_gland1.36448914
45MP0005023_abnormal_wound_healing1.32590916
46MP0004036_abnormal_muscle_relaxation1.27913696
47MP0001663_abnormal_digestive_system1.26918946
48MP0003763_abnormal_thymus_physiology1.26146232
49MP0000689_abnormal_spleen_morphology1.24775015
50MP0008004_abnormal_stomach_pH1.23600659
51MP0002429_abnormal_blood_cell1.22248169
52MP0000604_amyloidosis1.20262388
53MP0004858_abnormal_nervous_system1.20159013
54MP0005503_abnormal_tendon_morphology1.19056423
55MP0002933_joint_inflammation1.17867981
56MP0002722_abnormal_immune_system1.16119244
57MP0003448_altered_tumor_morphology1.10744226
58MP0001986_abnormal_taste_sensitivity1.08063778
59MP0006082_CNS_inflammation1.08055775
60MP0001545_abnormal_hematopoietic_system1.06109963
61MP0005397_hematopoietic_system_phenotyp1.06109963
62MP0009764_decreased_sensitivity_to1.03883252
63MP0004510_myositis1.02740873
64MP0002132_abnormal_respiratory_system1.01364200
65MP0002405_respiratory_system_inflammati1.01305900
66MP0008469_abnormal_protein_level0.98528014
67MP0002166_altered_tumor_susceptibility0.98209188
68MP0005085_abnormal_gallbladder_physiolo0.97699076
69MP0002136_abnormal_kidney_physiology0.94676936
70MP0003795_abnormal_bone_structure0.94607429
71MP0003950_abnormal_plasma_membrane0.94595225
72MP0003183_abnormal_peptide_metabolism0.93312066
73MP0004808_abnormal_hematopoietic_stem0.92970327
74MP0002876_abnormal_thyroid_physiology0.92195753
75MP0009333_abnormal_splenocyte_physiolog0.92067414
76MP0000249_abnormal_blood_vessel0.91651212
77MP0005332_abnormal_amino_acid0.87618258
78MP0003279_aneurysm0.87535081
79MP0005390_skeleton_phenotype0.86689289
80MP0001666_abnormal_nutrient_absorption0.85596025
81MP0005381_digestive/alimentary_phenotyp0.85110854
82MP0006054_spinal_hemorrhage0.84868746
83MP0009278_abnormal_bone_marrow0.84690979
84MP0000490_abnormal_crypts_of0.84049616
85MP0002998_abnormal_bone_remodeling0.83907596
86MP0003453_abnormal_keratinocyte_physiol0.83863913
87MP0001851_eye_inflammation0.83842023
88MP0002896_abnormal_bone_mineralization0.83840255
89MP0005165_increased_susceptibility_to0.82719273
90MP0000343_altered_response_to0.82123323
91MP0001542_abnormal_bone_strength0.80740856
92MP0001664_abnormal_digestion0.80427907
93MP0003091_abnormal_cell_migration0.80217637
94MP0004084_abnormal_cardiac_muscle0.78146515
95MP0005257_abnormal_intraocular_pressure0.77181372
96MP0003868_abnormal_feces_composition0.76968625
97MP0005584_abnormal_enzyme/coenzyme_acti0.74961169
98MP0002095_abnormal_skin_pigmentation0.74877878
99MP0000681_abnormal_thyroid_gland0.74647231
100MP0000858_altered_metastatic_potential0.74637180

Predicted human phenotypes

RankGene SetZ-score
1Nonimmune hydrops fetalis (HP:0001790)6.52496364
2Agammaglobulinemia (HP:0004432)5.73447811
3Prostate neoplasm (HP:0100787)5.31390010
4Abnormality of macrophages (HP:0004311)4.43832435
5Chronic sinusitis (HP:0011109)4.22042984
6Gastrointestinal infarctions (HP:0005244)4.16330540
7Systemic lupus erythematosus (HP:0002725)4.03811353
8Abnormality of the prostate (HP:0008775)3.92477369
9Thrombocytosis (HP:0001894)3.92229634
10Cellulitis (HP:0100658)3.69767815
11Recurrent bronchitis (HP:0002837)3.55342646
12Verrucae (HP:0200043)3.50835451
13Papilloma (HP:0012740)3.50835451
14Vertebral compression fractures (HP:0002953)3.35487233
15Recurrent pneumonia (HP:0006532)3.31753423
16Glucose intolerance (HP:0000833)3.25801083
17Osteomyelitis (HP:0002754)3.21142106
18Nephritis (HP:0000123)3.20000014
19Skin rash (HP:0000988)3.18488491
20Meningitis (HP:0001287)3.17937576
21Malnutrition (HP:0004395)3.17077381
22Peritonitis (HP:0002586)3.15095620
23Vasculitis (HP:0002633)3.14311414
24Glomerulonephritis (HP:0000099)3.13232934
25Eczematoid dermatitis (HP:0000976)3.04392982
26Abnormality of cells of the lymphoid lineage (HP:0012140)3.00282201
27Gingival bleeding (HP:0000225)2.93601052
28Hypoplasia of the pons (HP:0012110)2.90038904
29Abnormality of liposaccharide metabolism (HP:0010968)2.88247191
30Abnormality of glycosphingolipid metabolism (HP:0004343)2.88247191
31Abnormality of glycolipid metabolism (HP:0010969)2.88247191
32Abnormal glucose tolerance (HP:0001952)2.82622180
33Gastrointestinal stroma tumor (HP:0100723)2.80724320
34Interstitial pulmonary disease (HP:0006530)2.79111489
35Type I transferrin isoform profile (HP:0003642)2.78905074
36Spastic paraparesis (HP:0002313)2.78275566
37Reduced antithrombin III activity (HP:0001976)2.74843465
38IgA deficiency (HP:0002720)2.67341634
39Global brain atrophy (HP:0002283)2.64716494
40Abnormality of complement system (HP:0005339)2.64591253
41Nuclear cataract (HP:0100018)2.64295488
42Abnormality of the pons (HP:0007361)2.63146528
43Recurrent lower respiratory tract infections (HP:0002783)2.61403894
44Hematochezia (HP:0002573)2.60339319
45Acute hepatic failure (HP:0006554)2.60318326
46Testicular atrophy (HP:0000029)2.60011155
47Leukocytosis (HP:0001974)2.57997707
48Pulmonary infiltrates (HP:0002113)2.52667059
49Stroke (HP:0001297)2.50988850
50Inflammation of the large intestine (HP:0002037)2.50907330
51Complement deficiency (HP:0004431)2.50507667
52Hypokinesia (HP:0002375)2.47842053
53Purpura (HP:0000979)2.46459359
54Chest pain (HP:0100749)2.37775465
55Recurrent viral infections (HP:0004429)2.36475912
56Colitis (HP:0002583)2.34202443
57Hydroureter (HP:0000072)2.33445855
58Recurrent bacterial skin infections (HP:0005406)2.33076940
59Abnormality of the intrinsic pathway (HP:0010989)2.32264275
60Gastrointestinal inflammation (HP:0004386)2.31520907
61Megaloblastic anemia (HP:0001889)2.27829350
62Chronic obstructive pulmonary disease (HP:0006510)2.27485457
63Obstructive lung disease (HP:0006536)2.27485457
64Emphysema (HP:0002097)2.27197365
65Chronic otitis media (HP:0000389)2.26641675
66Recurrent abscess formation (HP:0002722)2.24883246
67Restrictive lung disease (HP:0002091)2.24282899
68Sepsis (HP:0100806)2.24136309
69Gingivitis (HP:0000230)2.21721326
70Curly hair (HP:0002212)2.21533492
71Abnormality of glutamine family amino acid metabolism (HP:0010902)2.18448773
72Abnormality of male internal genitalia (HP:0000022)2.17652381
73Abnormality of the pericardium (HP:0001697)2.15554741
74Persistence of primary teeth (HP:0006335)2.15302380
75Hemoptysis (HP:0002105)2.14816392
76Prolonged partial thromboplastin time (HP:0003645)2.14283523
77Spontaneous hematomas (HP:0007420)2.12752377
78Epistaxis (HP:0000421)2.11575723
79Proximal tubulopathy (HP:0000114)2.10728026
80Abnormal delayed hypersensitivity skin test (HP:0002963)2.08987911
81Follicular hyperkeratosis (HP:0007502)2.08703667
82Orchitis (HP:0100796)2.05388561
83Cutaneous melanoma (HP:0012056)2.03148216
84Abnormality of the nasal mucosa (HP:0000433)2.02835785
85Abnormality of the peritoneum (HP:0002585)2.02504265
86Myositis (HP:0100614)2.02194238
87Bronchitis (HP:0012387)2.01627233
88Premature loss of primary teeth (HP:0006323)1.99761212
89Hypoalbuminemia (HP:0003073)1.99723456
90Abnormal albumin level (HP:0012116)1.99723456
91Vacuolated lymphocytes (HP:0001922)1.97778136
92Dehydration (HP:0001944)1.96119497
93Urticaria (HP:0001025)1.94800026
94Lymphopenia (HP:0001888)1.94047990
95Decreased circulating renin level (HP:0003351)1.93637096
96Abnormality of B cell number (HP:0010975)1.92203517
97Hyperactive renin-angiotensin system (HP:0000841)1.89711230
98Mediastinal lymphadenopathy (HP:0100721)1.88932318
99Apathy (HP:0000741)1.88402817
100Hydroxyprolinuria (HP:0003080)1.86676256

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN25.53666319
2CAMKK25.18507424
3BRSK24.86323099
4ERN13.79766842
5FLT33.76063726
6TYK23.31111623
7IRAK42.99070480
8CAMKK12.90127577
9TESK22.84355917
10IRAK12.46804019
11IRAK22.24018117
12MET2.15855511
13MAP4K12.00312480
14BRSK11.94779017
15JAK31.84855105
16SIK31.73413571
17AKT31.64228078
18IKBKE1.62971776
19MST1R1.57508309
20MAP3K141.55703031
21PIK3CG1.55575936
22BLK1.52912443
23GRK11.45523282
24EIF2AK31.43229742
25ACVR1B1.38987809
26TBK11.31588299
27HCK1.30963380
28SYK1.29668862
29TXK1.25214257
30BTK1.24672111
31KIT1.17701595
32JAK11.15081431
33ITK1.15044176
34STK241.10950966
35TEC1.09972557
36RIPK41.08150560
37PRPF4B1.08026853
38FGFR41.07821803
39JAK21.03443632
40EPHA30.87402192
41PASK0.87055138
42CDC42BPA0.85564211
43MAP3K130.81995989
44MAPK110.81421143
45RIPK10.80121170
46RET0.77752663
47ZAP700.76849034
48LYN0.76172795
49MAP3K100.69715765
50IGF1R0.69375322
51CSK0.68630002
52SIK10.68538575
53MAP3K10.66000889
54MAP3K90.65886620
55FES0.64281806
56GRK60.64004565
57MAP3K110.63539888
58PIK3CA0.61128030
59MAPKAPK30.60468384
60CSF1R0.59150742
61STK38L0.58185249
62EPHB10.57618874
63PDGFRA0.56686105
64FER0.52977686
65MATK0.52334556
66PRKAA20.50419891
67IKBKB0.49923646
68TLK10.46376190
69FGFR30.46143156
70SIK20.42566234
71LMTK20.42400213
72EPHA20.40123728
73MAPKAPK50.39371584
74PRKG20.38351347
75PRKCQ0.36982071
76ABL10.35386189
77TAOK10.35357186
78LCK0.31988335
79PDK10.31933639
80MAP3K30.31732778
81STK110.31349514
82GRK50.31258236
83MAP3K120.28594227
84TAOK20.28407599
85TGFBR10.28050913
86MAP3K60.26576750
87BMPR20.25633197
88TGFBR20.24049238
89MAP2K30.23638480
90CAMK2B0.22079516
91MAPK70.21950890
92FYN0.20981979
93PAK30.19641767
94DDR20.18299816
95ABL20.17049664
96MAPK30.16758455
97NLK0.16582267
98HIPK20.14523143
99MARK30.14363948
100CDK60.13912566

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.78084799
2Intestinal immune network for IgA production_Homo sapiens_hsa046723.68673200
3Staphylococcus aureus infection_Homo sapiens_hsa051503.55218864
4Allograft rejection_Homo sapiens_hsa053303.15080904
5Autoimmune thyroid disease_Homo sapiens_hsa053203.07849657
6Graft-versus-host disease_Homo sapiens_hsa053322.86973650
7Primary immunodeficiency_Homo sapiens_hsa053402.58268677
8Leishmaniasis_Homo sapiens_hsa051402.40261664
9Type I diabetes mellitus_Homo sapiens_hsa049402.36222474
10B cell receptor signaling pathway_Homo sapiens_hsa046622.33489121
11Antigen processing and presentation_Homo sapiens_hsa046122.27098320
12Protein export_Homo sapiens_hsa030602.16907620
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.10130036
14Osteoclast differentiation_Homo sapiens_hsa043801.92925270
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.83359199
16Viral myocarditis_Homo sapiens_hsa054161.78107298
17Cyanoamino acid metabolism_Homo sapiens_hsa004601.70429825
18Sulfur metabolism_Homo sapiens_hsa009201.65064536
19Toxoplasmosis_Homo sapiens_hsa051451.62513309
20Other glycan degradation_Homo sapiens_hsa005111.61325417
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.58898159
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.40454637
23Hematopoietic cell lineage_Homo sapiens_hsa046401.38941487
24Tuberculosis_Homo sapiens_hsa051521.33842309
25Influenza A_Homo sapiens_hsa051641.31245842
26Rheumatoid arthritis_Homo sapiens_hsa053231.26203801
27Chemokine signaling pathway_Homo sapiens_hsa040621.16335780
28Fructose and mannose metabolism_Homo sapiens_hsa000511.15477725
29Pertussis_Homo sapiens_hsa051331.13474570
30TNF signaling pathway_Homo sapiens_hsa046681.09347785
31Malaria_Homo sapiens_hsa051441.06563625
32Herpes simplex infection_Homo sapiens_hsa051681.05450248
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02713515
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.00314995
35Phagosome_Homo sapiens_hsa041450.99800686
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99489653
37Complement and coagulation cascades_Homo sapiens_hsa046100.98552629
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97847514
39Regulation of autophagy_Homo sapiens_hsa041400.96711064
40Toll-like receptor signaling pathway_Homo sapiens_hsa046200.93965732
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90490810
42AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81039353
43Hepatitis C_Homo sapiens_hsa051600.80743730
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.75214900
45Caffeine metabolism_Homo sapiens_hsa002320.74566730
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73800883
47Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73374502
48Lysosome_Homo sapiens_hsa041420.73317011
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72984724
50Thyroid hormone synthesis_Homo sapiens_hsa049180.71891622
51Arginine biosynthesis_Homo sapiens_hsa002200.71456149
52Measles_Homo sapiens_hsa051620.71437201
53Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70140695
54N-Glycan biosynthesis_Homo sapiens_hsa005100.68267092
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68073678
56NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66375268
57Protein digestion and absorption_Homo sapiens_hsa049740.65222704
58African trypanosomiasis_Homo sapiens_hsa051430.63066316
59Acute myeloid leukemia_Homo sapiens_hsa052210.62070265
60Renal cell carcinoma_Homo sapiens_hsa052110.59627067
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59372525
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57265832
63Pancreatic secretion_Homo sapiens_hsa049720.56146559
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56012677
65Leukocyte transendothelial migration_Homo sapiens_hsa046700.54276844
66T cell receptor signaling pathway_Homo sapiens_hsa046600.53911007
67Systemic lupus erythematosus_Homo sapiens_hsa053220.53910168
68Amoebiasis_Homo sapiens_hsa051460.51968929
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.50906288
70Legionellosis_Homo sapiens_hsa051340.50741945
71Renin-angiotensin system_Homo sapiens_hsa046140.50167787
72Nitrogen metabolism_Homo sapiens_hsa009100.49582604
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48086254
74Prolactin signaling pathway_Homo sapiens_hsa049170.47685589
75Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46534178
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45542252
77Fat digestion and absorption_Homo sapiens_hsa049750.45527901
78Apoptosis_Homo sapiens_hsa042100.43907186
79Hepatitis B_Homo sapiens_hsa051610.43905012
80Linoleic acid metabolism_Homo sapiens_hsa005910.41504707
81Arachidonic acid metabolism_Homo sapiens_hsa005900.41427205
82PPAR signaling pathway_Homo sapiens_hsa033200.40309430
83Ether lipid metabolism_Homo sapiens_hsa005650.39101705
84Chronic myeloid leukemia_Homo sapiens_hsa052200.38669459
85Tryptophan metabolism_Homo sapiens_hsa003800.38016558
86HTLV-I infection_Homo sapiens_hsa051660.34659922
87Olfactory transduction_Homo sapiens_hsa047400.32784954
88Mineral absorption_Homo sapiens_hsa049780.32471268
89Starch and sucrose metabolism_Homo sapiens_hsa005000.30304754
90Epstein-Barr virus infection_Homo sapiens_hsa051690.30209636
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.29862765
92Dorso-ventral axis formation_Homo sapiens_hsa043200.29484785
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.28418526
94Thyroid cancer_Homo sapiens_hsa052160.27776112
95FoxO signaling pathway_Homo sapiens_hsa040680.26886044
96Platelet activation_Homo sapiens_hsa046110.26718214
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.26687943
98Pancreatic cancer_Homo sapiens_hsa052120.26619676
99Histidine metabolism_Homo sapiens_hsa003400.26370874
100VEGF signaling pathway_Homo sapiens_hsa043700.26233693

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