IGHV3-23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of respiratory burst (GO:0060267)9.02395004
2complement activation (GO:0006956)8.30488673
3glomerular filtration (GO:0003094)7.75196650
4renal filtration (GO:0097205)7.02513060
5protein activation cascade (GO:0072376)6.09973546
6regulation of respiratory burst (GO:0060263)5.99080716
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.95856017
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.92675624
9antibacterial humoral response (GO:0019731)5.86854058
10antimicrobial humoral response (GO:0019730)5.73723481
11antigen processing and presentation of endogenous antigen (GO:0019883)5.62412053
12Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)5.23671488
13immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00025.23671488
14Fc-gamma receptor signaling pathway (GO:0038094)5.23671488
15Fc receptor mediated stimulatory signaling pathway (GO:0002431)5.19957562
16humoral immune response (GO:0006959)5.06180065
17regulation of cellular extravasation (GO:0002691)4.34895893
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.17536999
19retina homeostasis (GO:0001895)4.04413840
20immunoglobulin mediated immune response (GO:0016064)3.79484101
21negative regulation of myotube differentiation (GO:0010832)3.79287936
22interferon-gamma-mediated signaling pathway (GO:0060333)3.72453714
23detection of bacterium (GO:0016045)3.69787278
24regulation of dendritic cell antigen processing and presentation (GO:0002604)3.69136640
25detection of other organism (GO:0098543)3.61112745
26negative regulation of cell killing (GO:0031342)3.49454062
27negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.49454062
28type I interferon signaling pathway (GO:0060337)3.45727638
29cellular response to type I interferon (GO:0071357)3.45727638
30response to type I interferon (GO:0034340)3.44312394
31regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.38007053
32regulation of antigen processing and presentation (GO:0002577)3.31202953
33immune response-activating cell surface receptor signaling pathway (GO:0002429)3.29642169
34angiotensin maturation (GO:0002003)3.25847755
35positive regulation of pseudopodium assembly (GO:0031274)3.22859934
36positive regulation of Cdc42 GTPase activity (GO:0043089)3.13187651
37germinal center formation (GO:0002467)3.10700239
38surfactant homeostasis (GO:0043129)3.10379327
39positive regulation of antigen processing and presentation (GO:0002579)3.09452476
40regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.02506477
41cellular response to interferon-gamma (GO:0071346)3.00809171
42negative regulation of bone resorption (GO:0045779)2.99989817
43positive regulation of gamma-delta T cell activation (GO:0046645)2.96823202
44production of molecular mediator of immune response (GO:0002440)2.91921514
45maintenance of gastrointestinal epithelium (GO:0030277)2.90848412
46regulation of pseudopodium assembly (GO:0031272)2.86254071
47intestinal absorption (GO:0050892)2.85806479
48oligosaccharide biosynthetic process (GO:0009312)2.84992308
49B cell mediated immunity (GO:0019724)2.84748003
50response to interferon-gamma (GO:0034341)2.80833927
51positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.73892874
52T-helper 1 type immune response (GO:0042088)2.72742389
53regulation of integrin activation (GO:0033623)2.70373798
54chronic inflammatory response (GO:0002544)2.69536358
55dendritic cell chemotaxis (GO:0002407)2.69533206
56detection of external biotic stimulus (GO:0098581)2.69092867
57regulation of vitamin metabolic process (GO:0030656)2.67002389
58protein-chromophore linkage (GO:0018298)2.66521788
59peptide catabolic process (GO:0043171)2.65004965
60NIK/NF-kappaB signaling (GO:0038061)2.63791265
61immune response-activating signal transduction (GO:0002757)2.56314541
62myeloid dendritic cell differentiation (GO:0043011)2.56084425
63virion attachment to host cell (GO:0019062)2.55348640
64adhesion of symbiont to host cell (GO:0044650)2.55348640
65COPI coating of Golgi vesicle (GO:0048205)2.52735995
66Golgi transport vesicle coating (GO:0048200)2.52735995
67activation of immune response (GO:0002253)2.52039079
68eosinophil chemotaxis (GO:0048245)2.48259792
69bundle of His cell to Purkinje myocyte communication (GO:0086069)2.47308258
70interferon-gamma secretion (GO:0072643)2.45548810
71regulation of T cell tolerance induction (GO:0002664)2.43267513
72T cell costimulation (GO:0031295)2.41806929
73respiratory burst (GO:0045730)2.41197843
74O-glycan processing (GO:0016266)2.39680389
75lymphocyte costimulation (GO:0031294)2.38089402
76positive regulation of macrophage differentiation (GO:0045651)2.36888981
77B cell receptor signaling pathway (GO:0050853)2.36380020
78regulation of type I interferon-mediated signaling pathway (GO:0060338)2.35732000
79regulation of B cell receptor signaling pathway (GO:0050855)2.35712637
80dendritic cell migration (GO:0036336)2.35290546
81myeloid dendritic cell activation (GO:0001773)2.34793480
82antigen processing and presentation via MHC class Ib (GO:0002475)2.34780331
83regulation of glucose import in response to insulin stimulus (GO:2001273)2.34164702
84regulation of guanylate cyclase activity (GO:0031282)2.33930065
85negative regulation of bone remodeling (GO:0046851)2.33610345
86negative regulation of complement activation (GO:0045916)2.32824607
87regulation of macrophage chemotaxis (GO:0010758)2.31786656
88regulation of regulatory T cell differentiation (GO:0045589)2.31210162
89negative regulation of calcium ion transport into cytosol (GO:0010523)2.31209121
90negative regulation of humoral immune response (GO:0002921)2.30250294
91regulation of necrotic cell death (GO:0010939)2.29471133
92negative regulation of anoikis (GO:2000811)2.28801742
93eosinophil migration (GO:0072677)2.27833383
94defense response to Gram-negative bacterium (GO:0050829)2.25834731
95modulation by symbiont of host immune response (GO:0052553)2.25553202
96positive regulation by symbiont of host defense response (GO:0052509)2.25553202
97modulation by symbiont of host defense response (GO:0052031)2.25553202
98modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.25553202
99positive regulation by organism of defense response of other organism involved in symbiotic interact2.25553202
100complement activation, classical pathway (GO:0006958)10.5258582

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.78664338
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.82861931
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.61910557
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.88295256
5RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.18490611
6CDX2_20551321_ChIP-Seq_CACO-2_Human2.85365732
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.69298043
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.62615033
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.57935834
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.26859798
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.25661402
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.18105308
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.16745202
14SOX2_27498859_Chip-Seq_STOMACH_Mouse2.09988670
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.97730859
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.92479591
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.90422170
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.89663663
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.88442399
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.84538174
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.82359459
22SMAD_19615063_ChIP-ChIP_OVARY_Human1.79267153
23BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.77699964
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.75617147
25FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.73626190
26STAT4_19710469_ChIP-ChIP_TH1__Mouse1.73449895
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.70346560
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.68723693
29CLOCK_20551151_ChIP-Seq_293T_Human1.65395470
30MYB_21317192_ChIP-Seq_ERMYB_Mouse1.65323147
31SOX2_20726797_ChIP-Seq_SW620_Human1.64403064
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.58738424
33RUNX_20019798_ChIP-Seq_JUKART_Human1.52733807
34FOXO3_23340844_ChIP-Seq_DLD1_Human1.52207491
35VDR_24763502_ChIP-Seq_THP-1_Human1.51072640
36Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.45673112
37LXR_22292898_ChIP-Seq_THP-1_Human1.43566261
38GATA4_25053715_ChIP-Seq_YYC3_Human1.43532591
39ESR1_21235772_ChIP-Seq_MCF-7_Human1.38060223
40MYB_26560356_Chip-Seq_TH2_Human1.36006190
41GATA6_25053715_ChIP-Seq_YYC3_Human1.35122062
42TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34395112
43ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.33918145
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.33158249
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.31870185
46VDR_21846776_ChIP-Seq_THP-1_Human1.31120623
47EGR1_19374776_ChIP-ChIP_THP-1_Human1.30708002
48ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.30410845
49KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29797528
50BRD4_27068464_Chip-Seq_AML-cells_Mouse1.25980716
51RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24757861
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23690321
53SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23064991
54RXR_22158963_ChIP-Seq_LIVER_Mouse1.22977325
55PPARA_22158963_ChIP-Seq_LIVER_Mouse1.22965478
56MAF_26560356_Chip-Seq_TH1_Human1.21891354
57SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.19604474
58LXR_22158963_ChIP-Seq_LIVER_Mouse1.18799283
59TCF7_22412390_ChIP-Seq_EML_Mouse1.17843618
60RUNX1_22412390_ChIP-Seq_EML_Mouse1.16800336
61SPI1_23127762_ChIP-Seq_K562_Human1.16333375
62CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15777232
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14903195
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14245452
65MYB_26560356_Chip-Seq_TH1_Human1.13710573
66GATA1_19941826_ChIP-Seq_K562_Human1.13504808
67CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13195234
68PPAR_26484153_Chip-Seq_NCI-H1993_Human1.12189706
69KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11637106
70VDR_24787735_ChIP-Seq_THP-1_Human1.11587310
71RACK7_27058665_Chip-Seq_MCF-7_Human1.09671425
72MYC_22102868_ChIP-Seq_BL_Human1.09400532
73EGR1_19032775_ChIP-ChIP_M12_Human1.08540040
74P63_26484246_Chip-Seq_KERATINOCYTES_Human1.08351760
75TCF4_18268006_ChIP-ChIP_LS174T_Human1.08166877
76ELK3_25401928_ChIP-Seq_HUVEC_Human1.07931080
77SPI1_23547873_ChIP-Seq_NB4_Human1.07841739
78GATA2_21666600_ChIP-Seq_HMVEC_Human1.06842085
79CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05840190
80SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05458109
81CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02054961
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01751392
83MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.00238800
84PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.99526626
85GATA1_22025678_ChIP-Seq_K562_Human0.98702703
86GATA2_19941826_ChIP-Seq_K562_Human0.98688897
87UTX_26944678_Chip-Seq_JUKART_Human0.96674475
88RUNX1_27514584_Chip-Seq_MCF-7_Human0.96588770
89NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96089483
90GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95822275
91RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.94317966
92PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.92578125
93PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91565100
94GATA1_19941827_ChIP-Seq_MEL_Mouse0.90759555
95SCL_19346495_ChIP-Seq_HPC-7_Human0.89897819
96EGR1_23403033_ChIP-Seq_LIVER_Mouse0.89195357
97ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87319976
98KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.81860698
99DROSHA_22980978_ChIP-Seq_HELA_Human0.81494346
100GATA3_27048872_Chip-Seq_THYMUS_Human0.81370966

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.91960238
2MP0010234_abnormal_vibrissa_follicle3.40044122
3MP0003303_peritoneal_inflammation3.36592565
4MP0001835_abnormal_antigen_presentation3.23242674
5MP0010155_abnormal_intestine_physiology3.01901517
6MP0003436_decreased_susceptibility_to2.89251577
7MP0005387_immune_system_phenotype2.85078622
8MP0001790_abnormal_immune_system2.85078622
9MP0003300_gastrointestinal_ulcer2.46670060
10MP0001800_abnormal_humoral_immune2.46622797
11MP0004264_abnormal_extraembryonic_tissu2.41293511
12MP0000685_abnormal_immune_system2.34650408
13MP0005025_abnormal_response_to2.32989007
14MP0003866_abnormal_defecation2.30544161
15MP0009785_altered_susceptibility_to2.20645066
16MP0010352_gastrointestinal_tract_polyps2.16263586
17MP0005000_abnormal_immune_tolerance2.07538350
18MP0000465_gastrointestinal_hemorrhage2.06199054
19MP0005671_abnormal_response_to2.05982923
20MP0005166_decreased_susceptibility_to1.98956779
21MP0005275_abnormal_skin_tensile1.97258002
22MP0002138_abnormal_hepatobiliary_system1.95638262
23MP0002166_altered_tumor_susceptibility1.95004235
24MP0003183_abnormal_peptide_metabolism1.93803203
25MP0004782_abnormal_surfactant_physiolog1.93474033
26MP0002452_abnormal_antigen_presenting1.93309936
27MP0001873_stomach_inflammation1.91575322
28MP0002148_abnormal_hypersensitivity_rea1.88042800
29MP0001533_abnormal_skeleton_physiology1.80292194
30MP0002139_abnormal_hepatobiliary_system1.78674386
31MP0002723_abnormal_immune_serum1.77121247
32MP0002419_abnormal_innate_immunity1.71383114
33MP0001819_abnormal_immune_cell1.69436149
34MP0002420_abnormal_adaptive_immunity1.68111052
35MP0004947_skin_inflammation1.66767353
36MP0001845_abnormal_inflammatory_respons1.61889203
37MP0006082_CNS_inflammation1.59827025
38MP0001663_abnormal_digestive_system1.56662495
39MP0008438_abnormal_cutaneous_collagen1.56438353
40MP0005310_abnormal_salivary_gland1.50912167
41MP0002006_tumorigenesis1.42385054
42MP0004858_abnormal_nervous_system1.40948227
43MP0003763_abnormal_thymus_physiology1.35652375
44MP0003191_abnormal_cellular_cholesterol1.34952422
45MP0001666_abnormal_nutrient_absorption1.34567041
46MP0008004_abnormal_stomach_pH1.33909927
47MP0003448_altered_tumor_morphology1.32590420
48MP0000477_abnormal_intestine_morphology1.30627461
49MP0003045_fibrosis1.30494245
50MP0000490_abnormal_crypts_of1.30086148
51MP0005503_abnormal_tendon_morphology1.29640876
52MP0009333_abnormal_splenocyte_physiolog1.29434347
53MP0002998_abnormal_bone_remodeling1.26507026
54MP0005085_abnormal_gallbladder_physiolo1.25334038
55MP0005023_abnormal_wound_healing1.23874152
56MP0005360_urolithiasis1.22943085
57MP0000716_abnormal_immune_system1.22811909
58MP0005381_digestive/alimentary_phenotyp1.18330095
59MP0001664_abnormal_digestion1.18228112
60MP0000858_altered_metastatic_potential1.16866643
61MP0003075_altered_response_to1.16863076
62MP0002796_impaired_skin_barrier1.12461109
63MP0002398_abnormal_bone_marrow1.12007688
64MP0003868_abnormal_feces_composition1.11916112
65MP0005464_abnormal_platelet_physiology1.07878228
66MP0000604_amyloidosis1.04951780
67MP0000343_altered_response_to1.04798546
68MP0009840_abnormal_foam_cell1.03486466
69MP0008469_abnormal_protein_level1.01775177
70MP0003279_aneurysm0.99830551
71MP0002405_respiratory_system_inflammati0.99342294
72MP0003453_abnormal_keratinocyte_physiol0.98660671
73MP0005365_abnormal_bile_salt0.96414493
74MP0002429_abnormal_blood_cell0.96412074
75MP0002933_joint_inflammation0.95155242
76MP0005165_increased_susceptibility_to0.94809213
77MP0005390_skeleton_phenotype0.93469569
78MP0005409_darkened_coat_color0.93132424
79MP0001542_abnormal_bone_strength0.92218295
80MP0003566_abnormal_cell_adhesion0.91361571
81MP0005058_abnormal_lysosome_morphology0.90860606
82MP0005451_abnormal_body_composition0.90627122
83MP0002896_abnormal_bone_mineralization0.90349373
84MP0003329_amyloid_beta_deposits0.89841973
85MP0001765_abnormal_ion_homeostasis0.89243916
86MP0000678_abnormal_parathyroid_gland0.89179481
87MP0000249_abnormal_blood_vessel0.88713858
88MP0009643_abnormal_urine_homeostasis0.87793172
89MP0003091_abnormal_cell_migration0.86681845
90MP0005164_abnormal_response_to0.86523508
91MP0001851_eye_inflammation0.85865805
92MP0002722_abnormal_immune_system0.83343923
93MP0002009_preneoplasia0.82457175
94MP0009764_decreased_sensitivity_to0.81986465
95MP0003828_pulmonary_edema0.81961830
96MP0002136_abnormal_kidney_physiology0.81849951
97MP0003252_abnormal_bile_duct0.80932311
98MP0000689_abnormal_spleen_morphology0.79961199
99MP0003795_abnormal_bone_structure0.79590878
100MP0002876_abnormal_thyroid_physiology0.77892494

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)5.73359590
2Prostate neoplasm (HP:0100787)5.25770840
3Abnormality of macrophages (HP:0004311)4.61192073
4Eczematoid dermatitis (HP:0000976)4.60454341
5Malnutrition (HP:0004395)4.15802865
6Hyperactive renin-angiotensin system (HP:0000841)4.12056082
7Abnormality of complement system (HP:0005339)3.74746715
8Abnormality of the prostate (HP:0008775)3.72189624
9Vasculitis (HP:0002633)3.67203569
10Agammaglobulinemia (HP:0004432)3.63525819
11Colitis (HP:0002583)3.59274129
12Glomerulonephritis (HP:0000099)3.54011107
13Gastrointestinal stroma tumor (HP:0100723)3.46614119
14Complement deficiency (HP:0004431)3.43711927
15Premature loss of primary teeth (HP:0006323)3.37170763
16Recurrent bronchitis (HP:0002837)3.35280940
17Cellulitis (HP:0100658)3.05692326
18Inflammation of the large intestine (HP:0002037)3.01486054
19Nephritis (HP:0000123)2.99642432
20Abnormality of cells of the lymphoid lineage (HP:0012140)2.96277839
21Recurrent bacterial skin infections (HP:0005406)2.93953982
22Spontaneous hematomas (HP:0007420)2.93842682
23Skin rash (HP:0000988)2.93714230
24Chronic diarrhea (HP:0002028)2.91303520
25Meningitis (HP:0001287)2.87645129
26Abnormality of B cell number (HP:0010975)2.87412678
27Gastrointestinal infarctions (HP:0005244)2.87198204
28Gastrointestinal inflammation (HP:0004386)2.86448230
29Osteomyelitis (HP:0002754)2.83624948
30Decreased circulating renin level (HP:0003351)2.82344491
31Increased IgE level (HP:0003212)2.80318196
32Abnormal delayed hypersensitivity skin test (HP:0002963)2.79522126
33Right ventricular cardiomyopathy (HP:0011663)2.78409812
34Recurrent abscess formation (HP:0002722)2.77031163
35Gingivitis (HP:0000230)2.75026176
36Flat acetabular roof (HP:0003180)2.71956913
37Urticaria (HP:0001025)2.67311464
38Leukocytosis (HP:0001974)2.63288304
39Recurrent viral infections (HP:0004429)2.59643585
40Abnormality of small intestinal villus morphology (HP:0011472)2.59000425
41Villous atrophy (HP:0011473)2.59000425
42Abnormality of the nasal mucosa (HP:0000433)2.51995200
43Abnormality of monocarboxylic acid metabolism (HP:0010996)2.51685422
44Abnormality of glutamine family amino acid metabolism (HP:0010902)2.50816428
45Recurrent sinusitis (HP:0011108)2.48214976
46Abnormality of renin-angiotensin system (HP:0000847)2.47282523
47Metabolic alkalosis (HP:0200114)2.47242852
48Emphysema (HP:0002097)2.46296631
49Chronic otitis media (HP:0000389)2.42204010
50Alopecia of scalp (HP:0002293)2.42019275
51Hemoptysis (HP:0002105)2.37056322
52B lymphocytopenia (HP:0010976)2.34902887
53Interstitial pulmonary disease (HP:0006530)2.31230208
54Myositis (HP:0100614)2.28691941
55Orchitis (HP:0100796)2.25139016
56Recurrent gram-negative bacterial infections (HP:0005420)2.24461270
57Mediastinal lymphadenopathy (HP:0100721)2.23392374
58Bronchitis (HP:0012387)2.21160628
59Recurrent pneumonia (HP:0006532)2.19090442
60Ileus (HP:0002595)2.18261189
61Pulmonary infiltrates (HP:0002113)2.18001642
62Abnormality of male internal genitalia (HP:0000022)2.17268057
63Alkalosis (HP:0001948)2.17031610
64Hemorrhage of the eye (HP:0011885)2.16176460
65Recurrent fungal infections (HP:0002841)2.11961815
66Neoplasm of the lung (HP:0100526)2.07273885
67Abnormality of chloride homeostasis (HP:0011422)2.06894114
68Flattened epiphyses (HP:0003071)2.06629837
69Recurrent skin infections (HP:0001581)2.06627605
70Pustule (HP:0200039)2.06530806
71Xerostomia (HP:0000217)2.05068648
72Obstructive lung disease (HP:0006536)2.04208332
73Chronic obstructive pulmonary disease (HP:0006510)2.04208332
74Restrictive lung disease (HP:0002091)2.04087827
75Osteolytic defects of the phalanges of the hand (HP:0009771)2.03377514
76Osteolytic defects of the hand bones (HP:0009699)2.03377514
77Abnormal hair laboratory examination (HP:0003328)2.02866377
78Hypergammaglobulinemia (HP:0010702)2.02317477
79Recurrent lower respiratory tract infections (HP:0002783)2.00214864
80Periodontitis (HP:0000704)1.99735028
81Elevated erythrocyte sedimentation rate (HP:0003565)1.99258042
82Skin ulcer (HP:0200042)1.97545303
83Pili torti (HP:0003777)1.94046340
84Autoimmune hemolytic anemia (HP:0001890)1.91806615
85Recurrent cutaneous fungal infections (HP:0011370)1.91237437
86Chronic mucocutaneous candidiasis (HP:0002728)1.91237437
87Fragile skin (HP:0001030)1.91117886
88Autoimmune thrombocytopenia (HP:0001973)1.89896892
89Nasal polyposis (HP:0100582)1.85512614
90Papilloma (HP:0012740)1.85000079
91Verrucae (HP:0200043)1.85000079
92Abnormality of T cell physiology (HP:0011840)1.84854675
93Abdominal distention (HP:0003270)1.84279014
94Segmental peripheral demyelination/remyelination (HP:0003481)1.83185633
95Hypermelanotic macule (HP:0001034)1.81824150
96Chest pain (HP:0100749)1.80734548
97Purpura (HP:0000979)1.80633390
98Polycythemia (HP:0001901)1.80350306
99Hyperaldosteronism (HP:0000859)1.79816053
100Retrobulbar optic neuritis (HP:0100654)1.79704834

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.62687770
2MST1R3.64902641
3TYK23.44645509
4FGFR43.31034144
5MAP4K12.92282635
6RIPK12.82738918
7RIPK42.78325725
8BLK2.68772915
9PRPF4B2.60143825
10EPHA32.57258555
11EPHB12.17728661
12JAK12.11895944
13FGFR32.01456497
14KIT1.98475180
15MAP3K141.91543167
16CDC42BPA1.88440553
17EPHA21.79331049
18JAK31.73977769
19IKBKE1.72680883
20PIK3CA1.67383242
21ACVR1B1.63076335
22IRAK41.48759591
23MAP3K101.48719283
24ZAP701.44974939
25CSK1.40753043
26TBK11.40682582
27PDGFRA1.26557583
28MAP3K11.26110138
29GRK61.25425773
30JAK21.25043828
31MATK1.23478772
32MET1.22740063
33FES1.17814062
34STK241.15510887
35FER1.15274931
36SYK1.10970937
37LYN1.09662142
38IRAK11.07448355
39DDR21.04709148
40PRKG21.04352389
41MAP3K131.04043347
42PTK61.02064057
43LMTK21.01110950
44SMG10.99383495
45SIK30.98197371
46CSF1R0.97495290
47NLK0.96122259
48PKN20.95066484
49BMPR20.94755447
50BTK0.92034807
51TXK0.91074570
52YES10.89932765
53EPHB20.89915138
54TRIB30.89638705
55STK390.80377158
56TAOK10.76659242
57TGFBR20.75302252
58RET0.74675009
59OXSR10.74002565
60HCK0.73378211
61MAP3K30.67879652
62MAP3K60.67223325
63FGR0.67098653
64MAPK70.65749836
65PDPK10.64905046
66LCK0.62627630
67IKBKB0.61259744
68MAP3K20.61202546
69HIPK20.60117545
70MYLK0.60068460
71TAOK30.58556035
72MAPK110.57697318
73FYN0.57516042
74CDK60.57313976
75PDGFRB0.56728100
76PAK40.54063146
77NEK90.53969900
78LRRK20.53841885
79TGFBR10.53690226
80PDK10.52665491
81MAPKAPK20.48377661
82KSR20.45690434
83DMPK0.43931173
84TESK20.42301427
85ITK0.41328909
86MAP2K30.39324588
87MAP2K20.33886253
88ERBB20.31915213
89IGF1R0.31340291
90SRC0.31248600
91TEC0.30940263
92PRKCQ0.30915096
93PRKCD0.30630329
94PDK20.30409304
95MAP2K60.30012882
96ABL10.26553573
97IRAK30.24816840
98PRKD20.24611690
99MELK0.24488688
100MAP3K120.23836756

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.61044271
2Asthma_Homo sapiens_hsa053103.51776848
3Allograft rejection_Homo sapiens_hsa053303.20831521
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.08744777
5Autoimmune thyroid disease_Homo sapiens_hsa053203.08004366
6Graft-versus-host disease_Homo sapiens_hsa053322.95606070
7Leishmaniasis_Homo sapiens_hsa051402.49773813
8Type I diabetes mellitus_Homo sapiens_hsa049402.45498366
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.32603841
10Cyanoamino acid metabolism_Homo sapiens_hsa004602.16400426
11Antigen processing and presentation_Homo sapiens_hsa046122.15748236
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.13313401
13Viral myocarditis_Homo sapiens_hsa054161.89385520
14Toxoplasmosis_Homo sapiens_hsa051451.56275097
15Primary immunodeficiency_Homo sapiens_hsa053401.54582201
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.54447727
17Pertussis_Homo sapiens_hsa051331.49266606
18Sulfur metabolism_Homo sapiens_hsa009201.46015035
19Other glycan degradation_Homo sapiens_hsa005111.43541223
20Influenza A_Homo sapiens_hsa051641.41248269
21Osteoclast differentiation_Homo sapiens_hsa043801.38654009
22Tuberculosis_Homo sapiens_hsa051521.36480435
23Hematopoietic cell lineage_Homo sapiens_hsa046401.30276536
24Renin-angiotensin system_Homo sapiens_hsa046141.30228167
25B cell receptor signaling pathway_Homo sapiens_hsa046621.30175719
26Arginine biosynthesis_Homo sapiens_hsa002201.27562532
27Rheumatoid arthritis_Homo sapiens_hsa053231.23735590
28Fat digestion and absorption_Homo sapiens_hsa049751.21757838
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20282410
30Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.17253333
31Mineral absorption_Homo sapiens_hsa049781.11864330
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.11510547
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.11126851
34Herpes simplex infection_Homo sapiens_hsa051681.09541362
35Fructose and mannose metabolism_Homo sapiens_hsa000511.08750161
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.07201465
37Hepatitis C_Homo sapiens_hsa051601.06975922
38Complement and coagulation cascades_Homo sapiens_hsa046101.03860841
39Phagosome_Homo sapiens_hsa041451.02172437
40Protein digestion and absorption_Homo sapiens_hsa049741.02050911
41Systemic lupus erythematosus_Homo sapiens_hsa053221.01866008
42TNF signaling pathway_Homo sapiens_hsa046680.97979140
43Nitrogen metabolism_Homo sapiens_hsa009100.97322696
44Chemokine signaling pathway_Homo sapiens_hsa040620.96301673
45Malaria_Homo sapiens_hsa051440.89172436
46Measles_Homo sapiens_hsa051620.87202792
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86433677
48Toll-like receptor signaling pathway_Homo sapiens_hsa046200.85130490
49African trypanosomiasis_Homo sapiens_hsa051430.82919559
50Pancreatic secretion_Homo sapiens_hsa049720.79757336
51Histidine metabolism_Homo sapiens_hsa003400.78471965
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78154403
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77100492
54Caffeine metabolism_Homo sapiens_hsa002320.74339562
55Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72635578
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72557416
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72286756
58Starch and sucrose metabolism_Homo sapiens_hsa005000.69995559
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69287175
60Amoebiasis_Homo sapiens_hsa051460.67843850
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.65772069
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.64501568
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61879285
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61640871
65Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.59787954
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58909230
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58799895
68Acute myeloid leukemia_Homo sapiens_hsa052210.58562500
69Arachidonic acid metabolism_Homo sapiens_hsa005900.55990354
70Galactose metabolism_Homo sapiens_hsa000520.55872658
71Apoptosis_Homo sapiens_hsa042100.53154157
72NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49363208
73Lysosome_Homo sapiens_hsa041420.47886545
74PPAR signaling pathway_Homo sapiens_hsa033200.47367753
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45987556
76RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45590937
77Pancreatic cancer_Homo sapiens_hsa052120.45384829
78Salmonella infection_Homo sapiens_hsa051320.45189625
79Hepatitis B_Homo sapiens_hsa051610.44620001
80Thyroid hormone synthesis_Homo sapiens_hsa049180.44618851
81Retinol metabolism_Homo sapiens_hsa008300.41837940
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40748049
83Platelet activation_Homo sapiens_hsa046110.40568298
84Prolactin signaling pathway_Homo sapiens_hsa049170.40519644
85Vitamin digestion and absorption_Homo sapiens_hsa049770.40516666
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40367516
87Arginine and proline metabolism_Homo sapiens_hsa003300.37305134
88Fatty acid degradation_Homo sapiens_hsa000710.36323809
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.35831782
90Linoleic acid metabolism_Homo sapiens_hsa005910.35795831
91HIF-1 signaling pathway_Homo sapiens_hsa040660.35645963
92T cell receptor signaling pathway_Homo sapiens_hsa046600.35552372
93HTLV-I infection_Homo sapiens_hsa051660.34987122
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33923781
95Bile secretion_Homo sapiens_hsa049760.33495405
96Ether lipid metabolism_Homo sapiens_hsa005650.32683236
97GnRH signaling pathway_Homo sapiens_hsa049120.32437098
98Prion diseases_Homo sapiens_hsa050200.29038188
99Legionellosis_Homo sapiens_hsa051340.28360317
100Sphingolipid metabolism_Homo sapiens_hsa006000.28313410

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