IGHV3-21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1complement activation (GO:0006956)9.70147251
2positive regulation of respiratory burst (GO:0060267)8.37580653
3glomerular filtration (GO:0003094)7.56323350
4protein activation cascade (GO:0072376)7.15262356
5renal filtration (GO:0097205)6.87324206
6Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)5.95952004
7immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00025.95952004
8Fc-gamma receptor signaling pathway (GO:0038094)5.95952004
9Fc receptor mediated stimulatory signaling pathway (GO:0002431)5.92013351
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.66760700
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.66013752
12regulation of respiratory burst (GO:0060263)5.53331272
13humoral immune response (GO:0006959)5.38688135
14antigen processing and presentation of endogenous antigen (GO:0019883)5.37435569
15antibacterial humoral response (GO:0019731)4.80374886
16antimicrobial humoral response (GO:0019730)4.75103032
17regulation of cellular extravasation (GO:0002691)4.19523835
18retina homeostasis (GO:0001895)4.11682635
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.99811330
20regulation of dendritic cell antigen processing and presentation (GO:0002604)3.77551680
21interferon-gamma-mediated signaling pathway (GO:0060333)3.67290844
22detection of bacterium (GO:0016045)3.62198058
23immunoglobulin mediated immune response (GO:0016064)3.58397894
24detection of other organism (GO:0098543)3.56682259
25immune response-activating cell surface receptor signaling pathway (GO:0002429)3.56330537
26negative regulation of cell killing (GO:0031342)3.52930597
27negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.52930597
28type I interferon signaling pathway (GO:0060337)3.44732077
29cellular response to type I interferon (GO:0071357)3.44732077
30response to type I interferon (GO:0034340)3.42512794
31regulation of antigen processing and presentation (GO:0002577)3.39387897
32regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.37587489
33angiotensin maturation (GO:0002003)3.32713464
34germinal center formation (GO:0002467)3.26659502
35positive regulation of antigen processing and presentation (GO:0002579)3.22583440
36negative regulation of myotube differentiation (GO:0010832)3.20068667
37surfactant homeostasis (GO:0043129)3.09703124
38chronic inflammatory response (GO:0002544)3.02007846
39positive regulation of pseudopodium assembly (GO:0031274)3.01320394
40virion attachment to host cell (GO:0019062)3.00813902
41adhesion of symbiont to host cell (GO:0044650)3.00813902
42cellular response to interferon-gamma (GO:0071346)2.97285941
43regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.95911770
44positive regulation of gamma-delta T cell activation (GO:0046645)2.94086073
45negative regulation of complement activation (GO:0045916)2.93295557
46dendritic cell chemotaxis (GO:0002407)2.89304411
47positive regulation of Cdc42 GTPase activity (GO:0043089)2.83152123
48response to interferon-gamma (GO:0034341)2.83046806
49production of molecular mediator of immune response (GO:0002440)2.79938164
50regulation of T cell tolerance induction (GO:0002664)2.74559480
51protein-chromophore linkage (GO:0018298)2.73810639
52immune response-activating signal transduction (GO:0002757)2.73139912
53detection of external biotic stimulus (GO:0098581)2.73080271
54activation of immune response (GO:0002253)2.72015244
55negative regulation of humoral immune response (GO:0002921)2.71522148
56peptide catabolic process (GO:0043171)2.71394096
57positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.70678492
58B cell mediated immunity (GO:0019724)2.69896084
59regulation of pseudopodium assembly (GO:0031272)2.66770690
60regulation of regulatory T cell differentiation (GO:0045589)2.59852013
61regulation of integrin activation (GO:0033623)2.59383258
62interferon-gamma secretion (GO:0072643)2.57717901
63negative regulation of protein activation cascade (GO:2000258)2.57586672
64myeloid dendritic cell differentiation (GO:0043011)2.52127592
65dendritic cell migration (GO:0036336)2.51806628
66intestinal absorption (GO:0050892)2.51043708
67maintenance of gastrointestinal epithelium (GO:0030277)2.50409462
68T-helper 1 type immune response (GO:0042088)2.49509412
69regulation of tolerance induction (GO:0002643)2.49034317
70NIK/NF-kappaB signaling (GO:0038061)2.46045550
71COPI coating of Golgi vesicle (GO:0048205)2.45663292
72Golgi transport vesicle coating (GO:0048200)2.45663292
73adhesion of symbiont to host (GO:0044406)2.44413288
74wound healing, spreading of epidermal cells (GO:0035313)2.41261395
75eosinophil chemotaxis (GO:0048245)2.41122118
76oligosaccharide biosynthetic process (GO:0009312)2.37013676
77bundle of His cell to Purkinje myocyte communication (GO:0086069)2.36835596
78regulation of vitamin metabolic process (GO:0030656)2.36810828
79regulation of macrophage chemotaxis (GO:0010758)2.34380895
80antigen processing and presentation via MHC class Ib (GO:0002475)2.31627634
81regulation of type I interferon-mediated signaling pathway (GO:0060338)2.31395308
82T cell costimulation (GO:0031295)2.31114071
83response to interferon-beta (GO:0035456)2.30596167
84myeloid dendritic cell activation (GO:0001773)2.30504212
85negative regulation of bone resorption (GO:0045779)2.30061854
86detection of biotic stimulus (GO:0009595)2.29793978
87regulation of B cell receptor signaling pathway (GO:0050855)2.28534522
88lymphocyte costimulation (GO:0031294)2.27542458
89regulation of necrotic cell death (GO:0010939)2.26448782
90regulation of chemokine secretion (GO:0090196)2.24815608
91positive regulation of type 2 immune response (GO:0002830)2.24118334
92positive regulation of T cell migration (GO:2000406)2.22981671
93respiratory burst (GO:0045730)2.21271196
94production of molecular mediator involved in inflammatory response (GO:0002532)2.21066985
95negative regulation of glycoprotein biosynthetic process (GO:0010561)2.20617122
96regulation of glucose import in response to insulin stimulus (GO:2001273)2.20106433
97regulation of T cell migration (GO:2000404)2.19993214
98eosinophil migration (GO:0072677)2.19860815
99regulation of gamma-delta T cell activation (GO:0046643)2.19710998
100complement activation, classical pathway (GO:0006958)12.2611728

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.79853439
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.87278236
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.83346451
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.10473434
5RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.19621906
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.18220781
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.91715670
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.80647411
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.66306617
10CDX2_20551321_ChIP-Seq_CACO-2_Human2.46204809
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.41833285
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.41186074
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.20644641
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.08075584
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.00723255
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.96335628
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.94374423
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.92362228
19SOX2_27498859_Chip-Seq_STOMACH_Mouse1.91661790
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.89244628
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.84775959
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.82171824
23BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.82115537
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.79046538
25CLOCK_20551151_ChIP-Seq_293T_Human1.78533863
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.75653840
27MYB_21317192_ChIP-Seq_ERMYB_Mouse1.74802624
28STAT4_19710469_ChIP-ChIP_TH1__Mouse1.72708850
29FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.66417433
30SOX2_20726797_ChIP-Seq_SW620_Human1.65011561
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.55911126
32RUNX_20019798_ChIP-Seq_JUKART_Human1.51406108
33FOXO3_23340844_ChIP-Seq_DLD1_Human1.50845648
34SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.49871247
35TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.46724721
36GATA4_25053715_ChIP-Seq_YYC3_Human1.37594568
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.36793875
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.33814889
39MYB_26560356_Chip-Seq_TH2_Human1.33756582
40FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.33680251
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.32092501
42ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.31338355
43VDR_24763502_ChIP-Seq_THP-1_Human1.31043586
44ESR1_21235772_ChIP-Seq_MCF-7_Human1.28811472
45EGR1_19374776_ChIP-ChIP_THP-1_Human1.26914235
46ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.25470835
47CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.23226751
48GATA2_21666600_ChIP-Seq_HMVEC_Human1.22433991
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.22183482
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20674942
51LXR_22158963_ChIP-Seq_LIVER_Mouse1.20287554
52RXR_22158963_ChIP-Seq_LIVER_Mouse1.19356662
53PPAR_26484153_Chip-Seq_NCI-H1993_Human1.19294464
54BRD4_27068464_Chip-Seq_AML-cells_Mouse1.17694109
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17342238
56CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17174821
57EGR1_19032775_ChIP-ChIP_M12_Human1.17030131
58GATA6_25053715_ChIP-Seq_YYC3_Human1.15550900
59PPARA_22158963_ChIP-Seq_LIVER_Mouse1.15366864
60SPI1_23127762_ChIP-Seq_K562_Human1.14945286
61LXR_22292898_ChIP-Seq_THP-1_Human1.14600350
62VDR_24787735_ChIP-Seq_THP-1_Human1.14590745
63P63_26484246_Chip-Seq_KERATINOCYTES_Human1.13920789
64TCF4_18268006_ChIP-ChIP_LS174T_Human1.13639085
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11497742
66SPI1_23547873_ChIP-Seq_NB4_Human1.09792721
67SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.09000906
68STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07897821
69GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06791537
70GATA1_22025678_ChIP-Seq_K562_Human1.06278901
71MAF_26560356_Chip-Seq_TH1_Human1.05741087
72RUNX1_22412390_ChIP-Seq_EML_Mouse1.05687822
73CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04961534
74KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04265910
75GATA1_19941826_ChIP-Seq_K562_Human1.02418439
76MYB_26560356_Chip-Seq_TH1_Human1.02323305
77CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.01612068
78KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98824875
79ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98164094
80ELK3_25401928_ChIP-Seq_HUVEC_Human0.97904394
81MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.93435688
82VDR_21846776_ChIP-Seq_THP-1_Human0.91813721
83NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91284821
84RACK7_27058665_Chip-Seq_MCF-7_Human0.91178740
85TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90277795
86TCF7_22412390_ChIP-Seq_EML_Mouse0.89320395
87RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.88953782
88GATA2_19941826_ChIP-Seq_K562_Human0.88306855
89PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.88026003
90SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.87483014
91SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.87483014
92PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.85374872
93UTX_26944678_Chip-Seq_JUKART_Human0.85294074
94GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84598201
95EGR1_23403033_ChIP-Seq_LIVER_Mouse0.84380446
96PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83629555
97TBX20_22328084_ChIP-Seq_HEART_Mouse0.82894895
98TBX20_22080862_ChIP-Seq_HEART_Mouse0.82894895
99PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.82528389
100SCL_19346495_ChIP-Seq_HPC-7_Human0.79943061

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.42355097
2MP0003303_peritoneal_inflammation3.26679249
3MP0010234_abnormal_vibrissa_follicle2.98495246
4MP0003436_decreased_susceptibility_to2.97315373
5MP0001835_abnormal_antigen_presentation2.93937982
6MP0010155_abnormal_intestine_physiology2.83921071
7MP0005275_abnormal_skin_tensile2.67373144
8MP0001790_abnormal_immune_system2.64865972
9MP0005387_immune_system_phenotype2.64865972
10MP0008438_abnormal_cutaneous_collagen2.39890750
11MP0001800_abnormal_humoral_immune2.37860990
12MP0004264_abnormal_extraembryonic_tissu2.37114746
13MP0009785_altered_susceptibility_to2.31930234
14MP0005025_abnormal_response_to2.31502246
15MP0000685_abnormal_immune_system2.25551767
16MP0003300_gastrointestinal_ulcer2.24652967
17MP0005166_decreased_susceptibility_to2.08193497
18MP0003866_abnormal_defecation2.05802565
19MP0000465_gastrointestinal_hemorrhage2.05600327
20MP0004782_abnormal_surfactant_physiolog2.03802702
21MP0005000_abnormal_immune_tolerance2.03616192
22MP0005503_abnormal_tendon_morphology2.01214837
23MP0001533_abnormal_skeleton_physiology2.01065433
24MP0010352_gastrointestinal_tract_polyps2.00049374
25MP0005671_abnormal_response_to1.98875654
26MP0002148_abnormal_hypersensitivity_rea1.92121149
27MP0002452_abnormal_antigen_presenting1.91125601
28MP0002419_abnormal_innate_immunity1.79866670
29MP0006082_CNS_inflammation1.76719288
30MP0002166_altered_tumor_susceptibility1.75681710
31MP0002723_abnormal_immune_serum1.75231733
32MP0001873_stomach_inflammation1.74972541
33MP0001819_abnormal_immune_cell1.66793173
34MP0002420_abnormal_adaptive_immunity1.65461717
35MP0004947_skin_inflammation1.60977723
36MP0001845_abnormal_inflammatory_respons1.60059163
37MP0003448_altered_tumor_morphology1.59889809
38MP0003183_abnormal_peptide_metabolism1.56972142
39MP0005023_abnormal_wound_healing1.53750835
40MP0004858_abnormal_nervous_system1.45995693
41MP0008004_abnormal_stomach_pH1.44350062
42MP0003191_abnormal_cellular_cholesterol1.43414403
43MP0002138_abnormal_hepatobiliary_system1.42924873
44MP0003279_aneurysm1.38852476
45MP0001663_abnormal_digestive_system1.38687289
46MP0002006_tumorigenesis1.34458013
47MP0005310_abnormal_salivary_gland1.31927838
48MP0003075_altered_response_to1.29098010
49MP0009333_abnormal_splenocyte_physiolog1.28388705
50MP0003763_abnormal_thymus_physiology1.28082843
51MP0002796_impaired_skin_barrier1.27392229
52MP0002998_abnormal_bone_remodeling1.24271472
53MP0000343_altered_response_to1.23009849
54MP0000858_altered_metastatic_potential1.20698070
55MP0003045_fibrosis1.20480446
56MP0000716_abnormal_immune_system1.19826435
57MP0001666_abnormal_nutrient_absorption1.17327230
58MP0005360_urolithiasis1.17004162
59MP0005085_abnormal_gallbladder_physiolo1.16914732
60MP0002933_joint_inflammation1.13346540
61MP0005390_skeleton_phenotype1.12896184
62MP0000604_amyloidosis1.12794773
63MP0002139_abnormal_hepatobiliary_system1.12423081
64MP0002405_respiratory_system_inflammati1.11728123
65MP0000477_abnormal_intestine_morphology1.11635390
66MP0005164_abnormal_response_to1.09820939
67MP0005464_abnormal_platelet_physiology1.09399034
68MP0009840_abnormal_foam_cell1.08267126
69MP0003566_abnormal_cell_adhesion1.08138990
70MP0003453_abnormal_keratinocyte_physiol1.06724408
71MP0002398_abnormal_bone_marrow1.06566415
72MP0008469_abnormal_protein_level1.06148320
73MP0000490_abnormal_crypts_of1.05197341
74MP0005381_digestive/alimentary_phenotyp1.03541641
75MP0003828_pulmonary_edema1.02906518
76MP0009764_decreased_sensitivity_to1.00687029
77MP0001851_eye_inflammation0.98630314
78MP0001958_emphysema0.96253651
79MP0001664_abnormal_digestion0.95549567
80MP0002060_abnormal_skin_morphology0.94721753
81MP0005165_increased_susceptibility_to0.93982149
82MP0002429_abnormal_blood_cell0.92766933
83MP0001542_abnormal_bone_strength0.92541904
84MP0000249_abnormal_blood_vessel0.91813239
85MP0005365_abnormal_bile_salt0.91631241
86MP0003868_abnormal_feces_composition0.91384431
87MP0003329_amyloid_beta_deposits0.89792991
88MP0002896_abnormal_bone_mineralization0.88057350
89MP0002277_abnormal_respiratory_mucosa0.86944208
90MP0003795_abnormal_bone_structure0.86026653
91MP0000681_abnormal_thyroid_gland0.85726809
92MP0001216_abnormal_epidermal_layer0.85562190
93MP0010678_abnormal_skin_adnexa0.84124154
94MP0005058_abnormal_lysosome_morphology0.83812755
95MP0002133_abnormal_respiratory_system0.83184819
96MP0005388_respiratory_system_phenotype0.83184819
97MP0005409_darkened_coat_color0.80111601
98MP0003091_abnormal_cell_migration0.80035878
99MP0002876_abnormal_thyroid_physiology0.80000832
100MP0002722_abnormal_immune_system0.77809850

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)6.36737807
2Prostate neoplasm (HP:0100787)6.19631168
3Abnormality of macrophages (HP:0004311)4.88493583
4Eczematoid dermatitis (HP:0000976)4.35177947
5Abnormality of the prostate (HP:0008775)4.23545664
6Abnormality of complement system (HP:0005339)4.17888119
7Malnutrition (HP:0004395)4.15923896
8Complement deficiency (HP:0004431)3.93719136
9Glomerulonephritis (HP:0000099)3.84226314
10Vasculitis (HP:0002633)3.65367923
11Alopecia of scalp (HP:0002293)3.37291257
12Premature loss of primary teeth (HP:0006323)3.35348666
13Gastrointestinal infarctions (HP:0005244)3.26430108
14Nephritis (HP:0000123)3.25551114
15Hyperactive renin-angiotensin system (HP:0000841)3.23350783
16Recurrent bronchitis (HP:0002837)3.16478132
17Leukocytosis (HP:0001974)2.99272335
18Recurrent bacterial skin infections (HP:0005406)2.96749496
19Gingivitis (HP:0000230)2.95429255
20Spontaneous hematomas (HP:0007420)2.90929765
21Gastrointestinal stroma tumor (HP:0100723)2.89347418
22Right ventricular cardiomyopathy (HP:0011663)2.87200978
23Abnormality of cells of the lymphoid lineage (HP:0012140)2.87035917
24Recurrent abscess formation (HP:0002722)2.83096043
25Agammaglobulinemia (HP:0004432)2.82707214
26Abnormal delayed hypersensitivity skin test (HP:0002963)2.82158592
27Skin rash (HP:0000988)2.76934838
28Chronic diarrhea (HP:0002028)2.74421000
29Increased IgE level (HP:0003212)2.72517842
30Colitis (HP:0002583)2.66766891
31Interstitial pulmonary disease (HP:0006530)2.55286451
32Osteolytic defects of the phalanges of the hand (HP:0009771)2.53879082
33Osteolytic defects of the hand bones (HP:0009699)2.53879082
34Urticaria (HP:0001025)2.52832210
35Meningitis (HP:0001287)2.52185725
36Atrophic scars (HP:0001075)2.52128374
37Myositis (HP:0100614)2.50919993
38Hemoptysis (HP:0002105)2.50801932
39Fragile skin (HP:0001030)2.50481031
40Periodontitis (HP:0000704)2.48492558
41Inflammation of the large intestine (HP:0002037)2.47764964
42Metaphyseal cupping (HP:0003021)2.45521062
43Abnormality of the nasal mucosa (HP:0000433)2.45268267
44Osteomyelitis (HP:0002754)2.44667085
45Cellulitis (HP:0100658)2.43967075
46Chronic otitis media (HP:0000389)2.41466744
47Abnormality of male internal genitalia (HP:0000022)2.38630732
48Orchitis (HP:0100796)2.37983963
49Villous atrophy (HP:0011473)2.35724762
50Abnormality of small intestinal villus morphology (HP:0011472)2.35724762
51Aortic dissection (HP:0002647)2.34429564
52Gastrointestinal inflammation (HP:0004386)2.33730708
53Neoplasm of the lung (HP:0100526)2.30024952
54Abnormality of monocarboxylic acid metabolism (HP:0010996)2.28876641
55Elevated erythrocyte sedimentation rate (HP:0003565)2.27897885
56Abnormality of glutamine family amino acid metabolism (HP:0010902)2.26289723
57Recurrent gram-negative bacterial infections (HP:0005420)2.23711624
58Decreased circulating renin level (HP:0003351)2.17289335
59Emphysema (HP:0002097)2.16540097
60Cerebral aneurysm (HP:0004944)2.14926625
61Pulmonary infiltrates (HP:0002113)2.14865495
62Recurrent viral infections (HP:0004429)2.14092887
63Hypergammaglobulinemia (HP:0010702)2.12805097
64Flat acetabular roof (HP:0003180)2.12629632
65Peritonitis (HP:0002586)2.11529647
66Abnormality of B cell number (HP:0010975)2.08239667
67Thick nail (HP:0001805)2.08062609
68Ankyloglossia (HP:0010296)2.08039923
69Recurrent skin infections (HP:0001581)2.07350359
70Pustule (HP:0200039)2.06384528
71Xerostomia (HP:0000217)2.06147075
72Obstructive lung disease (HP:0006536)2.05646153
73Chronic obstructive pulmonary disease (HP:0006510)2.05646153
74Ileus (HP:0002595)2.05373667
75Hypermelanotic macule (HP:0001034)2.04794161
76Mediastinal lymphadenopathy (HP:0100721)2.02065293
77Autoimmune hemolytic anemia (HP:0001890)2.00662226
78Recurrent fungal infections (HP:0002841)2.00331017
79Skin ulcer (HP:0200042)1.99703474
80Bronchitis (HP:0012387)1.99567271
81Abnormal hair laboratory examination (HP:0003328)1.99367307
82Autoimmune thrombocytopenia (HP:0001973)1.96136673
83Neoplasm of the respiratory system (HP:0100606)1.94135391
84Polygenic inheritance (HP:0010982)1.90861382
85Purpura (HP:0000979)1.90594830
86Pili torti (HP:0003777)1.89307169
87Cupped ribs (HP:0000887)1.87317830
88Optic neuritis (HP:0100653)1.86305397
89Retrobulbar optic neuritis (HP:0100654)1.86305397
90Abnormality of renin-angiotensin system (HP:0000847)1.86271691
91Restrictive lung disease (HP:0002091)1.85910749
92Hematochezia (HP:0002573)1.85810065
93Chest pain (HP:0100749)1.85247551
94Chronic mucocutaneous candidiasis (HP:0002728)1.84511511
95Recurrent cutaneous fungal infections (HP:0011370)1.84511511
96Abnormality of T cell number (HP:0011839)1.84178691
97Nasal polyposis (HP:0100582)1.80137376
98Neoplasm of head and neck (HP:0012288)1.79345648
99Esophageal neoplasm (HP:0100751)1.79345648
100Abnormality of primary teeth (HP:0006481)1.78595275

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.64913776
2TYK23.64943698
3MST1R3.60124787
4FGFR43.19568256
5BLK2.94684299
6RIPK12.83830611
7EPHA32.70065123
8MAP4K12.52108749
9RIPK42.45576239
10PRPF4B2.33471326
11JAK12.29292644
12EPHB12.26600632
13KIT2.04815672
14FGFR32.00503952
15CDC42BPA1.90788571
16JAK31.88879679
17MAP3K141.81048835
18ZAP701.64982742
19IKBKE1.64511264
20FES1.56654058
21CSK1.55487552
22PIK3CA1.55147690
23PDGFRA1.51326117
24EPHA21.46539899
25ACVR1B1.45612872
26STK241.41964162
27MET1.35843213
28FER1.32977134
29GRK61.30266960
30TBK11.29750761
31JAK21.29132042
32MAP3K11.25404058
33TXK1.23313259
34IRAK41.16141889
35LYN1.13849782
36IRAK11.11767047
37TGFBR21.08149639
38MATK1.04636296
39SYK1.04497297
40NLK1.03715527
41MAP3K100.98116578
42BMPR20.97898740
43PKN20.97807756
44MAP3K130.97171204
45DDR20.96962926
46SIK30.96877310
47TGFBR10.96564480
48MYLK0.95001398
49MAP3K30.92171186
50PTK60.91128954
51PRKG20.90878403
52CSF1R0.90652818
53YES10.87161900
54EPHB20.86358555
55PAK40.83981733
56SMG10.81602006
57BTK0.81045402
58RET0.79758269
59MAP3K60.79429975
60HCK0.79188873
61FGR0.72954647
62MAP3K20.72849065
63DMPK0.70189884
64TRIB30.69960388
65PDGFRB0.68581293
66TAOK10.68325017
67MAPK70.68091280
68LMTK20.66638524
69LCK0.65323809
70STK390.64999092
71CDK60.63742094
72LRRK20.63555422
73HIPK20.62263064
74FYN0.60347778
75IKBKB0.57710348
76OXSR10.55044521
77PDPK10.54762276
78PDK20.49730378
79MAPKAPK20.49270224
80MAP3K120.48948286
81MAP2K30.46443931
82ITK0.45831093
83TAOK30.41335224
84KSR20.40497386
85PDK10.40185464
86IRAK30.39035156
87IGF1R0.38980802
88EIF2AK30.35539771
89NEK90.35355508
90GRK50.35344965
91MAPK110.35240759
92FLT30.34913409
93PRKCD0.33662887
94MAP2K60.33482187
95TESK20.32517524
96SRC0.31976019
97TEC0.31930453
98MELK0.30181584
99ABL10.30002059
100ERBB20.28556579

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.94743413
2Asthma_Homo sapiens_hsa053103.41978697
3Allograft rejection_Homo sapiens_hsa053303.14703651
4Autoimmune thyroid disease_Homo sapiens_hsa053203.07096466
5Graft-versus-host disease_Homo sapiens_hsa053322.92181074
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.83651621
7Leishmaniasis_Homo sapiens_hsa051402.56584859
8Type I diabetes mellitus_Homo sapiens_hsa049402.39898037
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.21253864
10Antigen processing and presentation_Homo sapiens_hsa046122.19926963
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.19408280
12Viral myocarditis_Homo sapiens_hsa054161.92901693
13Cyanoamino acid metabolism_Homo sapiens_hsa004601.84221942
14Pertussis_Homo sapiens_hsa051331.76105075
15Toxoplasmosis_Homo sapiens_hsa051451.64969314
16Osteoclast differentiation_Homo sapiens_hsa043801.53328040
17Tuberculosis_Homo sapiens_hsa051521.45170600
18Influenza A_Homo sapiens_hsa051641.44918128
19Primary immunodeficiency_Homo sapiens_hsa053401.43386083
20Hematopoietic cell lineage_Homo sapiens_hsa046401.42663197
21Complement and coagulation cascades_Homo sapiens_hsa046101.41574537
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.34621634
23Rheumatoid arthritis_Homo sapiens_hsa053231.33739098
24Other glycan degradation_Homo sapiens_hsa005111.30998143
25Sulfur metabolism_Homo sapiens_hsa009201.29108558
26Renin-angiotensin system_Homo sapiens_hsa046141.26827533
27Phagosome_Homo sapiens_hsa041451.22848467
28Protein digestion and absorption_Homo sapiens_hsa049741.21255641
29Malaria_Homo sapiens_hsa051441.17622559
30Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.16389718
31B cell receptor signaling pathway_Homo sapiens_hsa046621.15868492
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.12379649
33Arginine biosynthesis_Homo sapiens_hsa002201.11594832
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.11479810
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.09961763
36Herpes simplex infection_Homo sapiens_hsa051681.09579624
37TNF signaling pathway_Homo sapiens_hsa046681.06770169
38Fat digestion and absorption_Homo sapiens_hsa049751.05000211
39Mineral absorption_Homo sapiens_hsa049781.04436338
40Hepatitis C_Homo sapiens_hsa051601.04020123
41Chemokine signaling pathway_Homo sapiens_hsa040621.02008938
42Measles_Homo sapiens_hsa051620.97483115
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95213229
44Amoebiasis_Homo sapiens_hsa051460.92525765
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90987414
46African trypanosomiasis_Homo sapiens_hsa051430.89495855
47Toll-like receptor signaling pathway_Homo sapiens_hsa046200.89093902
48Caffeine metabolism_Homo sapiens_hsa002320.86160432
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84048672
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83728104
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.83129366
52Fructose and mannose metabolism_Homo sapiens_hsa000510.81244251
53Histidine metabolism_Homo sapiens_hsa003400.78295415
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76744338
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76131365
56Jak-STAT signaling pathway_Homo sapiens_hsa046300.75250297
57Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72317950
58Starch and sucrose metabolism_Homo sapiens_hsa005000.71180050
59Pancreatic secretion_Homo sapiens_hsa049720.70924363
60Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69838340
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68971911
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.67834179
63Systemic lupus erythematosus_Homo sapiens_hsa053220.66327423
64Arachidonic acid metabolism_Homo sapiens_hsa005900.60533825
65Acute myeloid leukemia_Homo sapiens_hsa052210.59572341
66NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59444568
67Lysosome_Homo sapiens_hsa041420.57905342
68Apoptosis_Homo sapiens_hsa042100.54242859
69Salmonella infection_Homo sapiens_hsa051320.53311282
70Nitrogen metabolism_Homo sapiens_hsa009100.53228198
71Pancreatic cancer_Homo sapiens_hsa052120.50846403
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49971260
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49930134
74Platelet activation_Homo sapiens_hsa046110.49661160
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49609522
76Galactose metabolism_Homo sapiens_hsa000520.49180608
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48014897
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45829058
79PPAR signaling pathway_Homo sapiens_hsa033200.44645896
80Hepatitis B_Homo sapiens_hsa051610.44485695
81Thyroid hormone synthesis_Homo sapiens_hsa049180.43508061
82Legionellosis_Homo sapiens_hsa051340.43227977
83Retinol metabolism_Homo sapiens_hsa008300.42369409
84Prolactin signaling pathway_Homo sapiens_hsa049170.40277611
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39345239
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39012461
87Prion diseases_Homo sapiens_hsa050200.38922438
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38524133
89Vitamin digestion and absorption_Homo sapiens_hsa049770.38124992
90T cell receptor signaling pathway_Homo sapiens_hsa046600.37330730
91Linoleic acid metabolism_Homo sapiens_hsa005910.37025063
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.35309536
93HTLV-I infection_Homo sapiens_hsa051660.35227030
94Renal cell carcinoma_Homo sapiens_hsa052110.33333480
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33161164
96HIF-1 signaling pathway_Homo sapiens_hsa040660.32399045
97Shigellosis_Homo sapiens_hsa051310.31830149
98Ether lipid metabolism_Homo sapiens_hsa005650.29918552
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.29035140
100GnRH signaling pathway_Homo sapiens_hsa049120.27236816

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