IGHV2-26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1complement activation (GO:0006956)9.32977603
2protein activation cascade (GO:0072376)6.81833277
3positive regulation of respiratory burst (GO:0060267)6.74311319
4glomerular filtration (GO:0003094)6.59883376
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.06658344
6Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)6.02784338
7immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00026.02784338
8Fc-gamma receptor signaling pathway (GO:0038094)6.02784338
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.99698587
10Fc receptor mediated stimulatory signaling pathway (GO:0002431)5.98261892
11renal filtration (GO:0097205)5.96521690
12antigen processing and presentation of endogenous antigen (GO:0019883)5.87214410
13humoral immune response (GO:0006959)5.71520184
14antibacterial humoral response (GO:0019731)5.61891110
15antimicrobial humoral response (GO:0019730)5.47493538
16regulation of respiratory burst (GO:0060263)4.74096736
17immunoglobulin mediated immune response (GO:0016064)4.62498861
18detection of bacterium (GO:0016045)4.41867814
19interferon-gamma-mediated signaling pathway (GO:0060333)4.31174815
20regulation of dendritic cell antigen processing and presentation (GO:0002604)4.30493573
21detection of other organism (GO:0098543)4.27863450
22type I interferon signaling pathway (GO:0060337)4.12284809
23cellular response to type I interferon (GO:0071357)4.12284809
24response to type I interferon (GO:0034340)4.07739602
25regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.97658168
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.93313210
27regulation of antigen processing and presentation (GO:0002577)3.90807409
28immune response-activating cell surface receptor signaling pathway (GO:0002429)3.89726026
29retina homeostasis (GO:0001895)3.70443979
30germinal center formation (GO:0002467)3.65963151
31B cell mediated immunity (GO:0019724)3.64697938
32positive regulation of antigen processing and presentation (GO:0002579)3.59894721
33negative regulation of cell killing (GO:0031342)3.53560967
34negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.53560967
35T-helper 1 type immune response (GO:0042088)3.47565714
36positive regulation of gamma-delta T cell activation (GO:0046645)3.46581167
37cellular response to interferon-gamma (GO:0071346)3.37277472
38regulation of cellular extravasation (GO:0002691)3.33668193
39positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.31941503
40regulation of B cell receptor signaling pathway (GO:0050855)3.30800855
41detection of external biotic stimulus (GO:0098581)3.21766533
42surfactant homeostasis (GO:0043129)3.20411814
43myeloid dendritic cell differentiation (GO:0043011)3.19407117
44B cell receptor signaling pathway (GO:0050853)3.17374978
45innate immune response in mucosa (GO:0002227)3.13880214
46response to interferon-gamma (GO:0034341)3.13124314
47NIK/NF-kappaB signaling (GO:0038061)3.06655357
48immune response-activating signal transduction (GO:0002757)3.00476532
49myeloid dendritic cell activation (GO:0001773)2.97603800
50activation of immune response (GO:0002253)2.91270805
51production of molecular mediator of immune response (GO:0002440)2.85645650
52regulation of type I interferon-mediated signaling pathway (GO:0060338)2.84823341
53chronic inflammatory response (GO:0002544)2.83457786
54wound healing, spreading of epidermal cells (GO:0035313)2.76492848
55mucosal immune response (GO:0002385)2.76163939
56detection of biotic stimulus (GO:0009595)2.73683420
57positive regulation of T cell mediated cytotoxicity (GO:0001916)2.73648710
58T cell costimulation (GO:0031295)2.72086914
59adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.71698895
60adhesion of symbiont to host cell (GO:0044650)2.71077728
61virion attachment to host cell (GO:0019062)2.71077728
62regulation of T cell mediated cytotoxicity (GO:0001914)2.69279822
63positive regulation of neutrophil migration (GO:1902624)2.68078623
64positive regulation of neutrophil chemotaxis (GO:0090023)2.68078623
65lymphocyte costimulation (GO:0031294)2.68062347
66T cell migration (GO:0072678)2.66436814
67positive regulation by symbiont of host defense response (GO:0052509)2.66049834
68modulation by symbiont of host defense response (GO:0052031)2.66049834
69modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.66049834
70modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.66049834
71positive regulation by organism of defense response of other organism involved in symbiotic interact2.66049834
72modulation by symbiont of host immune response (GO:0052553)2.66049834
73organ or tissue specific immune response (GO:0002251)2.62908606
74regulation of integrin activation (GO:0033623)2.61897706
75COPI coating of Golgi vesicle (GO:0048205)2.60189678
76Golgi transport vesicle coating (GO:0048200)2.60189678
77positive thymic T cell selection (GO:0045059)2.59780810
78positive regulation of granulocyte chemotaxis (GO:0071624)2.58908079
79positive regulation of B cell differentiation (GO:0045579)2.55104487
80positive regulation of macrophage cytokine production (GO:0060907)2.55044337
81negative thymic T cell selection (GO:0045060)2.52731748
82respiratory burst (GO:0045730)2.52522417
83regulation of T cell tolerance induction (GO:0002664)2.52185674
84negative regulation of bone resorption (GO:0045779)2.52145958
85fibril organization (GO:0097435)2.51959349
86response to interferon-beta (GO:0035456)2.49453059
87B cell homeostasis (GO:0001782)2.49073490
88negative regulation of humoral immune response (GO:0002921)2.48792676
89positive regulation of T cell migration (GO:2000406)2.48773734
90regulation of macrophage cytokine production (GO:0010935)2.47567017
91positive regulation of type 2 immune response (GO:0002830)2.47321150
92cellular extravasation (GO:0045123)2.45174183
93response to interleukin-15 (GO:0070672)2.44989051
94positive regulation of Rho protein signal transduction (GO:0035025)2.43974012
95regulation of gamma-delta T cell activation (GO:0046643)2.43498602
96epithelial cell differentiation involved in prostate gland development (GO:0060742)2.43346233
97dendritic cell chemotaxis (GO:0002407)2.39448904
98positive regulation of Cdc42 GTPase activity (GO:0043089)2.38898096
99dendritic cell differentiation (GO:0097028)2.37269027
100complement activation, classical pathway (GO:0006958)11.8873473

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.38939553
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.31514742
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.15923468
4TP63_17297297_ChIP-ChIP_HaCaT_Human5.15149456
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.83945994
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.24075137
7RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.16625301
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.06690573
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.84128971
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.78883677
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.55320685
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.53123794
13STAT4_19710469_ChIP-ChIP_TH1__Mouse2.50837161
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.50013428
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.46769026
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.37025552
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.29632611
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.27437934
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.20317678
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.16538192
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.11687219
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07179005
23MYC_22102868_ChIP-Seq_BL_Human1.90152395
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.90075046
25MYB_26560356_Chip-Seq_TH2_Human1.78959824
26MAF_26560356_Chip-Seq_TH1_Human1.77788500
27MYB_21317192_ChIP-Seq_ERMYB_Mouse1.77065757
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.76990658
29CLOCK_20551151_ChIP-Seq_293T_Human1.75596054
30VDR_24763502_ChIP-Seq_THP-1_Human1.73247211
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.72859145
32VDR_21846776_ChIP-Seq_THP-1_Human1.69199886
33RUNX_20019798_ChIP-Seq_JUKART_Human1.65508881
34BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.63220674
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.62548757
36EGR1_23403033_ChIP-Seq_LIVER_Mouse1.59711809
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.56749361
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.52749074
39SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.49251741
40TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47713521
41MYB_26560356_Chip-Seq_TH1_Human1.47193518
42TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42910195
43LXR_22292898_ChIP-Seq_THP-1_Human1.39332262
44Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.36889728
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.35138610
46SPI1_23547873_ChIP-Seq_NB4_Human1.33170702
47SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.32402982
48CDX2_20551321_ChIP-Seq_CACO-2_Human1.31633458
49NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.28847874
50GATA1_22025678_ChIP-Seq_K562_Human1.28518082
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28185760
52UTX_26944678_Chip-Seq_JUKART_Human1.28087738
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.27336014
54TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24378564
55KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22753901
56TCF7_22412390_ChIP-Seq_EML_Mouse1.21714425
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.19832552
58SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18271076
59GATA1_19941826_ChIP-Seq_K562_Human1.18064474
60SPI1_23127762_ChIP-Seq_K562_Human1.16276777
61CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.13371763
62P63_26484246_Chip-Seq_KERATINOCYTES_Human1.10594147
63KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08593331
64RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.06783907
65SOX2_20726797_ChIP-Seq_SW620_Human1.05696905
66ELK3_25401928_ChIP-Seq_HUVEC_Human1.05252045
67SCL_19346495_ChIP-Seq_HPC-7_Human1.03784733
68RARG_19884340_ChIP-ChIP_MEFs_Mouse1.02682922
69VDR_24787735_ChIP-Seq_THP-1_Human1.02154399
70CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00916348
71GATA3_27048872_Chip-Seq_THYMUS_Human0.97881104
72GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96483001
73CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96070119
74PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94378849
75GATA2_21666600_ChIP-Seq_HMVEC_Human0.93380389
76HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92263741
77KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92022074
78EGR1_19032775_ChIP-ChIP_M12_Human0.90915595
79ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.89268386
80PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89146134
81SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.89038519
82STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.87200590
83LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.87086721
84VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.86987418
85SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.85656121
86SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.85656121
87PU_27001747_Chip-Seq_BMDM_Mouse0.85010629
88GATA2_19941826_ChIP-Seq_K562_Human0.83370955
89FOXO3_23340844_ChIP-Seq_DLD1_Human0.82495929
90FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80720286
91GATA1_19941827_ChIP-Seq_MEL_Mouse0.80346630
92RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.80286947
93MAF_26560356_Chip-Seq_TH2_Human0.80085404
94PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79443752
95ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.75448261
96KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.75030768
97RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.74570182
98SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.73776821
99GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.72030685
100CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.71260086

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.02835486
2MP0008438_abnormal_cutaneous_collagen3.83004099
3MP0003303_peritoneal_inflammation3.62044534
4MP0005275_abnormal_skin_tensile3.47397226
5MP0001835_abnormal_antigen_presentation3.45708053
6MP0001790_abnormal_immune_system3.25617802
7MP0005387_immune_system_phenotype3.25617802
8MP0000685_abnormal_immune_system3.25185245
9MP0003436_decreased_susceptibility_to3.14313137
10MP0001800_abnormal_humoral_immune2.92719307
11MP0003300_gastrointestinal_ulcer2.56938710
12MP0005671_abnormal_response_to2.53501723
13MP0005503_abnormal_tendon_morphology2.52098437
14MP0005025_abnormal_response_to2.48548462
15MP0005000_abnormal_immune_tolerance2.46326671
16MP0009785_altered_susceptibility_to2.40698211
17MP0010155_abnormal_intestine_physiology2.33328402
18MP0002452_abnormal_antigen_presenting2.31290358
19MP0002723_abnormal_immune_serum2.15894698
20MP0002148_abnormal_hypersensitivity_rea2.06633879
21MP0002420_abnormal_adaptive_immunity2.04863551
22MP0001819_abnormal_immune_cell2.03838542
23MP0002419_abnormal_innate_immunity1.94994044
24MP0010234_abnormal_vibrissa_follicle1.90922739
25MP0001533_abnormal_skeleton_physiology1.88400998
26MP0002166_altered_tumor_susceptibility1.87951053
27MP0003763_abnormal_thymus_physiology1.84286993
28MP0005166_decreased_susceptibility_to1.81411675
29MP0002138_abnormal_hepatobiliary_system1.81154230
30MP0000465_gastrointestinal_hemorrhage1.75188566
31MP0003183_abnormal_peptide_metabolism1.74807856
32MP0010352_gastrointestinal_tract_polyps1.74705745
33MP0004947_skin_inflammation1.66420773
34MP0004264_abnormal_extraembryonic_tissu1.64871867
35MP0001845_abnormal_inflammatory_respons1.64220356
36MP0003279_aneurysm1.62246430
37MP0003448_altered_tumor_morphology1.62215226
38MP0006082_CNS_inflammation1.60416053
39MP0003045_fibrosis1.55957606
40MP0000716_abnormal_immune_system1.53870737
41MP0002398_abnormal_bone_marrow1.51177204
42MP0002006_tumorigenesis1.49798965
43MP0003866_abnormal_defecation1.44349644
44MP0005023_abnormal_wound_healing1.44081189
45MP0009333_abnormal_splenocyte_physiolog1.44056031
46MP0000343_altered_response_to1.41100383
47MP0000858_altered_metastatic_potential1.40243443
48MP0005310_abnormal_salivary_gland1.32130252
49MP0004782_abnormal_surfactant_physiolog1.30384180
50MP0002405_respiratory_system_inflammati1.26557627
51MP0002429_abnormal_blood_cell1.24445843
52MP0001873_stomach_inflammation1.23165756
53MP0003566_abnormal_cell_adhesion1.22786759
54MP0002060_abnormal_skin_morphology1.22320260
55MP0005464_abnormal_platelet_physiology1.19376130
56MP0003191_abnormal_cellular_cholesterol1.18843462
57MP0002933_joint_inflammation1.18785312
58MP0005390_skeleton_phenotype1.15800235
59MP0001851_eye_inflammation1.13117888
60MP0002722_abnormal_immune_system1.13015446
61MP0003075_altered_response_to1.12888389
62MP0000689_abnormal_spleen_morphology1.12233062
63MP0009764_decreased_sensitivity_to1.08377487
64MP0003453_abnormal_keratinocyte_physiol1.05152885
65MP0002998_abnormal_bone_remodeling1.04658159
66MP0002796_impaired_skin_barrier1.03823115
67MP0008469_abnormal_protein_level1.02951766
68MP0001663_abnormal_digestive_system0.97684499
69MP0003091_abnormal_cell_migration0.96396527
70MP0002877_abnormal_melanocyte_morpholog0.93835260
71MP0003828_pulmonary_edema0.93686032
72MP0005164_abnormal_response_to0.91943392
73MP0001542_abnormal_bone_strength0.89934288
74MP0000579_abnormal_nail_morphology0.87577711
75MP0000604_amyloidosis0.84677519
76MP0005257_abnormal_intraocular_pressure0.84676907
77MP0000249_abnormal_blood_vessel0.83893439
78MP0001216_abnormal_epidermal_layer0.82195630
79MP0003795_abnormal_bone_structure0.80363971
80MP0001958_emphysema0.79540700
81MP0005165_increased_susceptibility_to0.78668427
82MP0002133_abnormal_respiratory_system0.78095629
83MP0005388_respiratory_system_phenotype0.78095629
84MP0008260_abnormal_autophagy0.76599208
85MP0000490_abnormal_crypts_of0.76005103
86MP0000703_abnormal_thymus_morphology0.75587331
87MP0000477_abnormal_intestine_morphology0.74867417
88MP0002277_abnormal_respiratory_mucosa0.74660753
89MP0002396_abnormal_hematopoietic_system0.73993589
90MP0008004_abnormal_stomach_pH0.73879730
91MP0009763_increased_sensitivity_to0.73853798
92MP0009278_abnormal_bone_marrow0.73430068
93MP0009931_abnormal_skin_appearance0.72426861
94MP0009840_abnormal_foam_cell0.72309684
95MP0004510_myositis0.71562749
96MP0005381_digestive/alimentary_phenotyp0.68861237
97MP0001853_heart_inflammation0.63846505
98MP0010678_abnormal_skin_adnexa0.63462946
99MP0005451_abnormal_body_composition0.63335528
100MP0000767_abnormal_smooth_muscle0.62563557

Predicted human phenotypes

RankGene SetZ-score
1Prostate neoplasm (HP:0100787)6.79504599
2Systemic lupus erythematosus (HP:0002725)5.42083319
3Abnormality of macrophages (HP:0004311)5.36719469
4Alopecia of scalp (HP:0002293)4.70633485
5Eczematoid dermatitis (HP:0000976)4.69822951
6Abnormality of the prostate (HP:0008775)4.65732722
7Premature loss of primary teeth (HP:0006323)4.48870744
8Recurrent bronchitis (HP:0002837)4.34012567
9Gastrointestinal stroma tumor (HP:0100723)4.29472190
10Vasculitis (HP:0002633)4.15874346
11Agammaglobulinemia (HP:0004432)3.76414087
12Gastrointestinal infarctions (HP:0005244)3.74807874
13Abnormality of cells of the lymphoid lineage (HP:0012140)3.74675273
14Abnormality of complement system (HP:0005339)3.64924119
15Recurrent bacterial skin infections (HP:0005406)3.62428204
16Urticaria (HP:0001025)3.43272506
17Skin rash (HP:0000988)3.32836592
18Cellulitis (HP:0100658)3.32330253
19Meningitis (HP:0001287)3.29616665
20Onycholysis (HP:0001806)3.26409378
21Complement deficiency (HP:0004431)3.22575802
22Glomerulonephritis (HP:0000099)3.15438792
23Recurrent abscess formation (HP:0002722)3.15402925
24Gingivitis (HP:0000230)3.10776850
25Leukocytosis (HP:0001974)3.00322157
26Increased IgE level (HP:0003212)3.00055317
27Atrophic scars (HP:0001075)2.99133436
28Abnormal delayed hypersensitivity skin test (HP:0002963)2.94733723
29Fragile skin (HP:0001030)2.87475765
30Osteolytic defects of the phalanges of the hand (HP:0009771)2.84798449
31Osteolytic defects of the hand bones (HP:0009699)2.84798449
32Osteomyelitis (HP:0002754)2.80333376
33Xerostomia (HP:0000217)2.80301242
34Recurrent sinusitis (HP:0011108)2.78606789
35Recurrent gram-negative bacterial infections (HP:0005420)2.78463854
36Spontaneous hematomas (HP:0007420)2.78207955
37Abnormality of male internal genitalia (HP:0000022)2.78168394
38Nephritis (HP:0000123)2.75986545
39Mediastinal lymphadenopathy (HP:0100721)2.75402271
40Emphysema (HP:0002097)2.74952297
41Aortic dissection (HP:0002647)2.69222742
42Colitis (HP:0002583)2.68130936
43Cerebral aneurysm (HP:0004944)2.66407942
44Ridged nail (HP:0001807)2.61354217
45Malnutrition (HP:0004395)2.58200211
46Hemoptysis (HP:0002105)2.57535330
47Periodontitis (HP:0000704)2.52158464
48Bronchitis (HP:0012387)2.50005732
49Thick nail (HP:0001805)2.49838783
50IgM deficiency (HP:0002850)2.49559276
51Chronic otitis media (HP:0000389)2.47267902
52Hypermelanotic macule (HP:0001034)2.44795069
53Recurrent viral infections (HP:0004429)2.43134078
54Recurrent skin infections (HP:0001581)2.42531502
55Erythema (HP:0010783)2.41655889
56Chronic obstructive pulmonary disease (HP:0006510)2.38999956
57Obstructive lung disease (HP:0006536)2.38999956
58Inflammation of the large intestine (HP:0002037)2.38173912
59Dry hair (HP:0011359)2.37512370
60Recurrent pneumonia (HP:0006532)2.36098792
61Lymphopenia (HP:0001888)2.32257196
62Conical tooth (HP:0000698)2.31286847
63Recurrent lower respiratory tract infections (HP:0002783)2.30804296
64Skin ulcer (HP:0200042)2.30516841
65Recurrent fungal infections (HP:0002841)2.30172678
66Blepharitis (HP:0000498)2.29689560
67Gastrointestinal inflammation (HP:0004386)2.28237496
68Myositis (HP:0100614)2.27550858
69Abnormality of primary teeth (HP:0006481)2.27251055
70Pulmonary infiltrates (HP:0002113)2.25999811
71Bladder diverticulum (HP:0000015)2.24650914
72Abnormality of T cell physiology (HP:0011840)2.23735423
73Chronic diarrhea (HP:0002028)2.22818806
74Abnormal hair laboratory examination (HP:0003328)2.20902575
75Orchitis (HP:0100796)2.20266464
76Hypergammaglobulinemia (HP:0010702)2.20262836
77Elevated erythrocyte sedimentation rate (HP:0003565)2.19283500
78Restrictive lung disease (HP:0002091)2.18235785
79Metaphyseal cupping (HP:0003021)2.16389162
80IgA deficiency (HP:0002720)2.14640981
81Neoplasm of the lung (HP:0100526)2.12536878
82Autoimmune hemolytic anemia (HP:0001890)2.11800633
83Interstitial pulmonary disease (HP:0006530)2.11468280
84Right ventricular cardiomyopathy (HP:0011663)2.07166650
85Abnormality of the pleura (HP:0002103)2.07126684
86Chronic mucocutaneous candidiasis (HP:0002728)2.03551829
87Recurrent cutaneous fungal infections (HP:0011370)2.03551829
88Abnormality of the nasal mucosa (HP:0000433)2.03376518
89Hypotrichosis (HP:0001006)2.02212418
90Plantar hyperkeratosis (HP:0007556)1.96924561
91Abnormality of B cell number (HP:0010975)1.93810549
92Peritonitis (HP:0002586)1.93653618
93Dilatation of the ascending aorta (HP:0005111)1.93326028
94Increased IgM level (HP:0003496)1.91961354
95Autoimmune thrombocytopenia (HP:0001973)1.91202381
96Acrocyanosis (HP:0001063)1.89276198
97Abnormality of the peritoneum (HP:0002585)1.88845571
98Sepsis (HP:0100806)1.88352054
99Optic neuritis (HP:0100653)1.86399505
100Retrobulbar optic neuritis (HP:0100654)1.86399505

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.81808403
2TYK23.36911789
3FGFR43.33676337
4BLK3.17575350
5RIPK43.09475391
6PRPF4B3.04845928
7MAP4K13.03849299
8EPHA32.62598473
9IRAK42.41073869
10JAK12.34377574
11MAP3K142.25288675
12VRK12.24057194
13KIT2.23789103
14EPHB12.23150917
15TLK12.07389762
16IKBKE1.94727010
17JAK31.93332706
18CDC42BPA1.92016369
19FGFR31.87138793
20TGFBR11.65592661
21TBK11.65493945
22SMG11.63692127
23PDGFRA1.61915085
24RIPK11.50015784
25SYK1.47864345
26MST1R1.42762605
27MAP3K131.39829347
28JAK21.38959036
29CSK1.38917804
30LYN1.35421682
31DAPK31.25633278
32FES1.23203227
33NEK91.18724284
34ZAP701.15345001
35ZAK1.14557922
36STK241.14547553
37MAP3K11.13469708
38GRK61.07912602
39CSF1R1.07496747
40IKBKB1.04586992
41DDR21.02278830
42BTK1.00373504
43SIK30.98736564
44TXK0.97574322
45FER0.94939732
46RPS6KA50.92356188
47MATK0.90335766
48IRAK10.88289111
49MAPK70.86178666
50HIPK20.84169517
51BMPR20.78506387
52NLK0.77725134
53FGR0.75132554
54YES10.70802554
55LCK0.69014691
56TGFBR20.68646581
57PKN20.68131947
58MAP3K30.68088114
59HCK0.67427991
60MAP3K100.66963144
61RET0.65704335
62CDK60.65167723
63PAK40.63336787
64DMPK0.52449421
65FYN0.51403283
66KSR20.50323058
67LRRK20.50075549
68PTK60.49455448
69TRIB30.49295212
70MAPKAPK20.48333997
71TAF10.48014712
72PDGFRB0.47854619
73PIK3CA0.47684949
74MYLK0.46404582
75PRKCQ0.45900954
76EIF2AK30.45602058
77PRKCD0.45226416
78MAP3K60.41453095
79TESK20.39779541
80TAOK10.39622708
81ABL10.37406769
82PDK20.35912243
83PDPK10.34931807
84PIM10.34565263
85LATS10.33279855
86MAPK110.32974095
87GRK50.32872401
88ALK0.32100664
89STK100.31967847
90PDK10.31655191
91MAPK120.29664507
92STK40.29531778
93KDR0.29472475
94ITK0.28174028
95MAP3K20.26861721
96MAP2K30.26697252
97TAOK20.25813122
98INSR0.25756118
99MAP3K80.25352013
100MET0.23654914

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053224.08216634
2Asthma_Homo sapiens_hsa053104.07595063
3Staphylococcus aureus infection_Homo sapiens_hsa051503.91836750
4Allograft rejection_Homo sapiens_hsa053303.73829385
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.64029319
6Autoimmune thyroid disease_Homo sapiens_hsa053203.56068189
7Graft-versus-host disease_Homo sapiens_hsa053323.38695742
8Type I diabetes mellitus_Homo sapiens_hsa049402.85399610
9Leishmaniasis_Homo sapiens_hsa051402.76240903
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.49633026
11Antigen processing and presentation_Homo sapiens_hsa046122.44459984
12Viral myocarditis_Homo sapiens_hsa054162.39009434
13Primary immunodeficiency_Homo sapiens_hsa053402.35152115
14Alcoholism_Homo sapiens_hsa050341.82952169
15B cell receptor signaling pathway_Homo sapiens_hsa046621.68200298
16Toxoplasmosis_Homo sapiens_hsa051451.67795199
17Influenza A_Homo sapiens_hsa051641.58368093
18Rheumatoid arthritis_Homo sapiens_hsa053231.51354594
19Osteoclast differentiation_Homo sapiens_hsa043801.50996888
20Tuberculosis_Homo sapiens_hsa051521.49578028
21Hematopoietic cell lineage_Homo sapiens_hsa046401.48275825
22Herpes simplex infection_Homo sapiens_hsa051681.40839744
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.36746207
24Pertussis_Homo sapiens_hsa051331.36529497
25Malaria_Homo sapiens_hsa051441.36055726
26Phagosome_Homo sapiens_hsa041451.35837569
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.26746782
28Viral carcinogenesis_Homo sapiens_hsa052031.23609903
29Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.20837735
30Measles_Homo sapiens_hsa051621.19823247
31Chemokine signaling pathway_Homo sapiens_hsa040621.02981556
32Complement and coagulation cascades_Homo sapiens_hsa046101.01660307
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.01620777
34TNF signaling pathway_Homo sapiens_hsa046680.99519138
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.98514969
36Leukocyte transendothelial migration_Homo sapiens_hsa046700.95796487
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89545500
38AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88628007
39Hepatitis C_Homo sapiens_hsa051600.87637727
40Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86075430
41African trypanosomiasis_Homo sapiens_hsa051430.83349901
42Protein digestion and absorption_Homo sapiens_hsa049740.78506306
43Renin-angiotensin system_Homo sapiens_hsa046140.76434488
44Jak-STAT signaling pathway_Homo sapiens_hsa046300.76101511
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.75114457
46Amoebiasis_Homo sapiens_hsa051460.73791672
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73291830
48Other glycan degradation_Homo sapiens_hsa005110.70971543
49Apoptosis_Homo sapiens_hsa042100.68838140
50HTLV-I infection_Homo sapiens_hsa051660.66994432
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.65516742
52Fructose and mannose metabolism_Homo sapiens_hsa000510.65068571
53Acute myeloid leukemia_Homo sapiens_hsa052210.62736509
54Pancreatic cancer_Homo sapiens_hsa052120.62032997
55Hepatitis B_Homo sapiens_hsa051610.61700856
56Epstein-Barr virus infection_Homo sapiens_hsa051690.60418415
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59010819
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56013243
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52506389
60Platelet activation_Homo sapiens_hsa046110.51813623
61Prion diseases_Homo sapiens_hsa050200.46018366
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45667530
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45306434
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.44707362
65T cell receptor signaling pathway_Homo sapiens_hsa046600.44203152
66NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43708519
67Renal cell carcinoma_Homo sapiens_hsa052110.41818493
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41101026
69Prolactin signaling pathway_Homo sapiens_hsa049170.40986381
70Shigellosis_Homo sapiens_hsa051310.40457296
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39297208
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37406150
73Sulfur metabolism_Homo sapiens_hsa009200.37402840
74Lysosome_Homo sapiens_hsa041420.36149467
75HIF-1 signaling pathway_Homo sapiens_hsa040660.34734248
76Salmonella infection_Homo sapiens_hsa051320.33119884
77Legionellosis_Homo sapiens_hsa051340.32864656
78Chronic myeloid leukemia_Homo sapiens_hsa052200.32786646
79Starch and sucrose metabolism_Homo sapiens_hsa005000.31381899
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30324574
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28170728
82Small cell lung cancer_Homo sapiens_hsa052220.27600993
83Focal adhesion_Homo sapiens_hsa045100.26666384
84ECM-receptor interaction_Homo sapiens_hsa045120.25094253
85Bladder cancer_Homo sapiens_hsa052190.24178126
86N-Glycan biosynthesis_Homo sapiens_hsa005100.24074041
87VEGF signaling pathway_Homo sapiens_hsa043700.23777925
88Proteoglycans in cancer_Homo sapiens_hsa052050.22958972
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22479558
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.22384438
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.21841526
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.19004356
93Galactose metabolism_Homo sapiens_hsa000520.18303370
94Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.17377159
95Arginine biosynthesis_Homo sapiens_hsa002200.17157505
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.16983987
97Pancreatic secretion_Homo sapiens_hsa049720.16832076
98GnRH signaling pathway_Homo sapiens_hsa049120.16730648
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.15804916
100Arachidonic acid metabolism_Homo sapiens_hsa005900.15218834

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