IGHV1-3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1complement activation, classical pathway (GO:0006958)9.63956313
2positive regulation of respiratory burst (GO:0060267)8.82171620
3complement activation (GO:0006956)7.63840988
4glomerular filtration (GO:0003094)7.35109403
5renal filtration (GO:0097205)6.66275560
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.02533487
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.98458621
8regulation of respiratory burst (GO:0060263)5.94951829
9protein activation cascade (GO:0072376)5.79580542
10antigen processing and presentation of endogenous antigen (GO:0019883)5.64778719
11Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)4.87908962
12immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00024.87908962
13Fc-gamma receptor signaling pathway (GO:0038094)4.87908962
14Fc receptor mediated stimulatory signaling pathway (GO:0002431)4.85954475
15antimicrobial humoral response (GO:0019730)4.81206029
16antibacterial humoral response (GO:0019731)4.79264971
17retina homeostasis (GO:0001895)4.61757602
18humoral immune response (GO:0006959)4.56766182
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.36306741
20regulation of cellular extravasation (GO:0002691)4.26841278
21detection of bacterium (GO:0016045)4.06313833
22detection of other organism (GO:0098543)3.92492080
23negative regulation of cell killing (GO:0031342)3.63249682
24negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.63249682
25immunoglobulin mediated immune response (GO:0016064)3.61002912
26interferon-gamma-mediated signaling pathway (GO:0060333)3.52706218
27regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.48434790
28cellular response to type I interferon (GO:0071357)3.35443543
29type I interferon signaling pathway (GO:0060337)3.35443543
30response to type I interferon (GO:0034340)3.34887320
31negative regulation of myotube differentiation (GO:0010832)3.30420308
32arginine catabolic process (GO:0006527)3.30368138
33maintenance of gastrointestinal epithelium (GO:0030277)3.18535387
34immune response-activating cell surface receptor signaling pathway (GO:0002429)3.16059981
35germinal center formation (GO:0002467)3.12586309
36regulation of guanylate cyclase activity (GO:0031282)3.09912383
37regulation of dendritic cell antigen processing and presentation (GO:0002604)3.08605208
38regulation of antigen processing and presentation (GO:0002577)3.06054957
39cellular response to interferon-gamma (GO:0071346)3.01853906
40positive regulation of Cdc42 GTPase activity (GO:0043089)2.98151117
41positive regulation of gamma-delta T cell activation (GO:0046645)2.96355550
42production of molecular mediator of immune response (GO:0002440)2.96311622
43regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.91283530
44positive regulation of pseudopodium assembly (GO:0031274)2.87920498
45positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.86446841
46oligosaccharide biosynthetic process (GO:0009312)2.86327646
47B cell mediated immunity (GO:0019724)2.84361613
48positive regulation of antigen processing and presentation (GO:0002579)2.82758238
49response to interferon-gamma (GO:0034341)2.82498973
50NIK/NF-kappaB signaling (GO:0038061)2.82046879
51intestinal absorption (GO:0050892)2.80755394
52regulation of integrin activation (GO:0033623)2.79853544
53angiotensin maturation (GO:0002003)2.74011458
54detection of external biotic stimulus (GO:0098581)2.73845780
55O-glycan processing (GO:0016266)2.69827545
56bundle of His cell to Purkinje myocyte communication (GO:0086069)2.69099026
57peptide catabolic process (GO:0043171)2.68028616
58defense response to Gram-negative bacterium (GO:0050829)2.66062332
59myeloid dendritic cell differentiation (GO:0043011)2.62226915
60dendritic cell chemotaxis (GO:0002407)2.61716882
61positive regulation of guanylate cyclase activity (GO:0031284)2.60796840
62antigen processing and presentation via MHC class Ib (GO:0002475)2.60065285
63regulation of RIG-I signaling pathway (GO:0039535)2.58158988
64interferon-gamma secretion (GO:0072643)2.57377440
65regulation of regulatory T cell differentiation (GO:0045589)2.56829832
66regulation of T cell tolerance induction (GO:0002664)2.56269668
67regulation of pseudopodium assembly (GO:0031272)2.56103744
68thrombin receptor signaling pathway (GO:0070493)2.54406010
69protein-chromophore linkage (GO:0018298)2.53301709
70arginine metabolic process (GO:0006525)2.50264333
71establishment of skin barrier (GO:0061436)2.49283540
72regulation of water loss via skin (GO:0033561)2.49234881
73regulation of viral release from host cell (GO:1902186)2.48342757
74chronic inflammatory response (GO:0002544)2.47485872
75respiratory burst (GO:0045730)2.47389418
76immune response-activating signal transduction (GO:0002757)2.46033045
77regulation of transforming growth factor beta1 production (GO:0032908)2.45965703
78myeloid dendritic cell activation (GO:0001773)2.45110739
79epithelial structure maintenance (GO:0010669)2.45051580
80T-helper 1 type immune response (GO:0042088)2.43425058
81T cell costimulation (GO:0031295)2.42604049
82activation of immune response (GO:0002253)2.41912941
83lymphocyte costimulation (GO:0031294)2.38830210
84neutrophil activation involved in immune response (GO:0002283)2.38285207
85surfactant homeostasis (GO:0043129)2.34463997
86regulation of tolerance induction (GO:0002643)2.34139661
87eosinophil chemotaxis (GO:0048245)2.34108456
88desmosome organization (GO:0002934)2.33652780
89regulation of necrotic cell death (GO:0010939)2.31520870
90multicellular organismal water homeostasis (GO:0050891)2.30398484
91B cell receptor signaling pathway (GO:0050853)2.28761777
92detection of biotic stimulus (GO:0009595)2.28492630
93regulation of gamma-delta T cell activation (GO:0046643)2.27525330
94regulation of glucose import in response to insulin stimulus (GO:2001273)2.27473280
95positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.27177389
96GDP-mannose metabolic process (GO:0019673)2.26975244
97regulation of type I interferon-mediated signaling pathway (GO:0060338)2.24480276
98positive regulation of T cell migration (GO:2000406)2.23610925
99regulation of T cell migration (GO:2000404)2.22963093
100dendritic cell migration (GO:0036336)2.22419450

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.29780569
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.75763085
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.47598202
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.54460307
5RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.21248880
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.88416222
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.72416243
8CDX2_20551321_ChIP-Seq_CACO-2_Human2.57780429
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.52009826
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.15320802
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.10472029
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.04475087
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.03820444
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.95513429
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.93854393
16SOX2_27498859_Chip-Seq_STOMACH_Mouse1.93774185
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.93592215
18STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.87413498
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.74404858
20SOX2_20726797_ChIP-Seq_SW620_Human1.71767658
21MYB_21317192_ChIP-Seq_ERMYB_Mouse1.71386856
22STAT4_19710469_ChIP-ChIP_TH1__Mouse1.67924732
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.62891839
24LXR_22292898_ChIP-Seq_THP-1_Human1.60516844
25E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.59705469
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.55689053
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.55669464
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55598704
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.50210734
30BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.50062658
31GATA4_25053715_ChIP-Seq_YYC3_Human1.49004395
32RUNX_20019798_ChIP-Seq_JUKART_Human1.48409940
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45310284
34FOXO3_23340844_ChIP-Seq_DLD1_Human1.44825517
35VDR_24763502_ChIP-Seq_THP-1_Human1.44066313
36Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.43974666
37FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.42577179
38CLOCK_20551151_ChIP-Seq_293T_Human1.33606656
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.32554851
40TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31370595
41FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.31358918
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.30569969
43GATA6_25053715_ChIP-Seq_YYC3_Human1.30265578
44MYB_26560356_Chip-Seq_TH2_Human1.29633890
45TRIM28_21343339_ChIP-Seq_HEK293_Human1.29248059
46SPI1_23127762_ChIP-Seq_K562_Human1.29139291
47GATA1_19941826_ChIP-Seq_K562_Human1.28845977
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.28432409
49ESR1_21235772_ChIP-Seq_MCF-7_Human1.27839749
50RXR_22158963_ChIP-Seq_LIVER_Mouse1.26132030
51ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.26042508
52P63_26484246_Chip-Seq_KERATINOCYTES_Human1.25744658
53ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.24751332
54PPARA_22158963_ChIP-Seq_LIVER_Mouse1.24539562
55GATA2_21666600_ChIP-Seq_HMVEC_Human1.24332213
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24022909
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21201632
58SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.21108389
59MAF_26560356_Chip-Seq_TH1_Human1.20271366
60KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19231672
61VDR_21846776_ChIP-Seq_THP-1_Human1.19175434
62ELK3_25401928_ChIP-Seq_HUVEC_Human1.18954375
63BRD4_27068464_Chip-Seq_AML-cells_Mouse1.18826396
64SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.18037498
65TCF7_22412390_ChIP-Seq_EML_Mouse1.16972535
66CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16337822
67GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15872754
68MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.15182758
69MYC_22102868_ChIP-Seq_BL_Human1.14726716
70SCL_19346495_ChIP-Seq_HPC-7_Human1.14678040
71EGR1_19032775_ChIP-ChIP_M12_Human1.11584006
72GATA2_19941826_ChIP-Seq_K562_Human1.10908780
73LXR_22158963_ChIP-Seq_LIVER_Mouse1.10606221
74EGR1_19374776_ChIP-ChIP_THP-1_Human1.09873488
75RACK7_27058665_Chip-Seq_MCF-7_Human1.09747918
76UTX_26944678_Chip-Seq_JUKART_Human1.09668760
77GATA1_19941827_ChIP-Seq_MEL_Mouse1.09553497
78MYB_26560356_Chip-Seq_TH1_Human1.09518633
79PPAR_26484153_Chip-Seq_NCI-H1993_Human1.08296615
80TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08080574
81KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07322865
82PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.06903009
83CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06312995
84SPI1_23547873_ChIP-Seq_NB4_Human1.04359030
85CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02850440
86LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02261589
87NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02227573
88CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99488756
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98783253
90LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.97361448
91SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95276691
92TCF4_18268006_ChIP-ChIP_LS174T_Human0.94708325
93PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.94523405
94GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94022806
95VDR_24787735_ChIP-Seq_THP-1_Human0.93749744
96PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93300348
97SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92619374
98CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91457636
99DROSHA_22980978_ChIP-Seq_HELA_Human0.90910458
100STAT6_21828071_ChIP-Seq_BEAS2B_Human0.90052078

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.89399836
2MP0010234_abnormal_vibrissa_follicle3.79293530
3MP0010155_abnormal_intestine_physiology3.07249579
4MP0003303_peritoneal_inflammation3.06731351
5MP0001835_abnormal_antigen_presentation3.00943962
6MP0003436_decreased_susceptibility_to2.82193756
7MP0005387_immune_system_phenotype2.79966088
8MP0001790_abnormal_immune_system2.79966088
9MP0005671_abnormal_response_to2.57787963
10MP0004782_abnormal_surfactant_physiolog2.39857573
11MP0001800_abnormal_humoral_immune2.38819582
12MP0000685_abnormal_immune_system2.27953906
13MP0005025_abnormal_response_to2.27127810
14MP0004858_abnormal_nervous_system2.26412371
15MP0003866_abnormal_defecation2.26195701
16MP0001873_stomach_inflammation2.25402979
17MP0009785_altered_susceptibility_to2.23835169
18MP0004264_abnormal_extraembryonic_tissu2.21464231
19MP0010352_gastrointestinal_tract_polyps2.18629511
20MP0000465_gastrointestinal_hemorrhage2.16654923
21MP0004947_skin_inflammation2.12293031
22MP0005464_abnormal_platelet_physiology2.11398584
23MP0003300_gastrointestinal_ulcer2.07048732
24MP0005000_abnormal_immune_tolerance2.06472356
25MP0005275_abnormal_skin_tensile2.03603577
26MP0002138_abnormal_hepatobiliary_system2.00967199
27MP0005166_decreased_susceptibility_to1.99291554
28MP0001533_abnormal_skeleton_physiology1.91093551
29MP0002452_abnormal_antigen_presenting1.85830979
30MP0002796_impaired_skin_barrier1.84096546
31MP0002148_abnormal_hypersensitivity_rea1.83840944
32MP0008004_abnormal_stomach_pH1.81426365
33MP0002723_abnormal_immune_serum1.76470912
34MP0002139_abnormal_hepatobiliary_system1.65738975
35MP0002419_abnormal_innate_immunity1.63892090
36MP0001819_abnormal_immune_cell1.63436449
37MP0001663_abnormal_digestive_system1.60941982
38MP0002420_abnormal_adaptive_immunity1.60444955
39MP0001845_abnormal_inflammatory_respons1.57862834
40MP0002166_altered_tumor_susceptibility1.56660148
41MP0003183_abnormal_peptide_metabolism1.48856664
42MP0003329_amyloid_beta_deposits1.46684216
43MP0003763_abnormal_thymus_physiology1.45095391
44MP0005023_abnormal_wound_healing1.41161732
45MP0003075_altered_response_to1.40616191
46MP0009333_abnormal_splenocyte_physiolog1.40434377
47MP0002876_abnormal_thyroid_physiology1.38048031
48MP0006082_CNS_inflammation1.37867163
49MP0003191_abnormal_cellular_cholesterol1.37676764
50MP0000343_altered_response_to1.36779380
51MP0005310_abnormal_salivary_gland1.36294654
52MP0000604_amyloidosis1.32651915
53MP0003448_altered_tumor_morphology1.31979450
54MP0001664_abnormal_digestion1.30211624
55MP0003453_abnormal_keratinocyte_physiol1.21657047
56MP0000490_abnormal_crypts_of1.21586349
57MP0000477_abnormal_intestine_morphology1.21048750
58MP0005381_digestive/alimentary_phenotyp1.19872726
59MP0000716_abnormal_immune_system1.18440311
60MP0002998_abnormal_bone_remodeling1.16106431
61MP0003045_fibrosis1.15748389
62MP0002006_tumorigenesis1.15139531
63MP0002398_abnormal_bone_marrow1.14636280
64MP0000858_altered_metastatic_potential1.10944644
65MP0001666_abnormal_nutrient_absorption1.07756670
66MP0003566_abnormal_cell_adhesion1.03341511
67MP0005085_abnormal_gallbladder_physiolo1.02065264
68MP0008469_abnormal_protein_level0.98514181
69MP0009840_abnormal_foam_cell0.98016297
70MP0001216_abnormal_epidermal_layer0.97889565
71MP0000249_abnormal_blood_vessel0.96039028
72MP0002405_respiratory_system_inflammati0.95680259
73MP0005058_abnormal_lysosome_morphology0.95158222
74MP0008438_abnormal_cutaneous_collagen0.95155276
75MP0010678_abnormal_skin_adnexa0.94924246
76MP0002429_abnormal_blood_cell0.94815896
77MP0001851_eye_inflammation0.92677329
78MP0005390_skeleton_phenotype0.92159887
79MP0005360_urolithiasis0.90346800
80MP0005164_abnormal_response_to0.90071610
81MP0005501_abnormal_skin_physiology0.87627214
82MP0005451_abnormal_body_composition0.86178335
83MP0004510_myositis0.83902266
84MP0003868_abnormal_feces_composition0.83723462
85MP0002277_abnormal_respiratory_mucosa0.83604652
86MP0000681_abnormal_thyroid_gland0.83437607
87MP0002933_joint_inflammation0.83136042
88MP0002722_abnormal_immune_system0.81706539
89MP0002136_abnormal_kidney_physiology0.80324629
90MP0009764_decreased_sensitivity_to0.80262916
91MP0009643_abnormal_urine_homeostasis0.80258942
92MP0004043_abnormal_pH_regulation0.79644441
93MP0005165_increased_susceptibility_to0.78867265
94MP0002098_abnormal_vibrissa_morphology0.78026538
95MP0005409_darkened_coat_color0.76215043
96MP0003828_pulmonary_edema0.75595145
97MP0000689_abnormal_spleen_morphology0.75208027
98MP0005503_abnormal_tendon_morphology0.74911779
99MP0003091_abnormal_cell_migration0.74100704
100MP0001765_abnormal_ion_homeostasis0.73818025

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)5.59080816
2Prostate neoplasm (HP:0100787)4.95595220
3Abnormality of macrophages (HP:0004311)4.51569884
4Eczematoid dermatitis (HP:0000976)4.30777913
5Malnutrition (HP:0004395)3.81702430
6Increased IgE level (HP:0003212)3.77122743
7Hyperactive renin-angiotensin system (HP:0000841)3.67895322
8Abnormality of the prostate (HP:0008775)3.65783867
9Vasculitis (HP:0002633)3.59875503
10Abnormality of complement system (HP:0005339)3.58770629
11Glomerulonephritis (HP:0000099)3.56034501
12Premature loss of primary teeth (HP:0006323)3.45855197
13Complement deficiency (HP:0004431)3.43469291
14Gastrointestinal stroma tumor (HP:0100723)3.30009608
15Spontaneous hematomas (HP:0007420)3.28969509
16Recurrent bronchitis (HP:0002837)3.20817855
17Agammaglobulinemia (HP:0004432)3.19445846
18Right ventricular cardiomyopathy (HP:0011663)3.05815745
19Nephritis (HP:0000123)3.04620862
20Villous atrophy (HP:0011473)3.02353311
21Abnormality of small intestinal villus morphology (HP:0011472)3.02353311
22Colitis (HP:0002583)3.00244933
23Abnormal delayed hypersensitivity skin test (HP:0002963)2.98152828
24Abnormality of cells of the lymphoid lineage (HP:0012140)2.93250989
25Inflammation of the large intestine (HP:0002037)2.93196571
26Purpura (HP:0000979)2.91710530
27Urticaria (HP:0001025)2.88327325
28Decreased circulating renin level (HP:0003351)2.82620098
29Recurrent bacterial skin infections (HP:0005406)2.81823615
30Gastrointestinal inflammation (HP:0004386)2.79452001
31Meningitis (HP:0001287)2.75041201
32Skin rash (HP:0000988)2.74787342
33Abnormality of the nasal mucosa (HP:0000433)2.74150561
34Abnormality of monocarboxylic acid metabolism (HP:0010996)2.73734046
35Gingivitis (HP:0000230)2.71304491
36Abnormality of glutamine family amino acid metabolism (HP:0010902)2.70803599
37Pustule (HP:0200039)2.67934196
38Leukocytosis (HP:0001974)2.66716250
39Emphysema (HP:0002097)2.62885306
40Chronic diarrhea (HP:0002028)2.61267131
41Cellulitis (HP:0100658)2.58261297
42Recurrent abscess formation (HP:0002722)2.58170861
43Gastrointestinal infarctions (HP:0005244)2.57804129
44Chronic otitis media (HP:0000389)2.55132622
45Alopecia of scalp (HP:0002293)2.52487830
46Autoimmune hemolytic anemia (HP:0001890)2.51867730
47Gingival bleeding (HP:0000225)2.48257944
48Ileus (HP:0002595)2.44746460
49Prolonged bleeding time (HP:0003010)2.44005896
50Petechiae (HP:0000967)2.43321810
51Flat acetabular roof (HP:0003180)2.41439202
52Osteomyelitis (HP:0002754)2.39745619
53Recurrent viral infections (HP:0004429)2.38575351
54Hypergammaglobulinemia (HP:0010702)2.37491761
55Abnormality of B cell number (HP:0010975)2.32550461
56Hemorrhage of the eye (HP:0011885)2.32021610
57Epistaxis (HP:0000421)2.28709578
58Myositis (HP:0100614)2.27646707
59Alkalosis (HP:0001948)2.27187642
60Abnormality of renin-angiotensin system (HP:0000847)2.25817442
61Hemoptysis (HP:0002105)2.24859277
62Orchitis (HP:0100796)2.24780741
63Increased IgM level (HP:0003496)2.19778382
64Recurrent sinusitis (HP:0011108)2.19703307
65Autoimmune thrombocytopenia (HP:0001973)2.18920539
66Metabolic alkalosis (HP:0200114)2.15069334
67Periodontitis (HP:0000704)2.13637094
68Bronchitis (HP:0012387)2.12832248
69Recurrent fungal infections (HP:0002841)2.12542613
70Nasal polyposis (HP:0100582)2.12426831
71Pulmonary infiltrates (HP:0002113)2.11251630
72Pili torti (HP:0003777)2.10076651
73Chronic obstructive pulmonary disease (HP:0006510)2.09537571
74Obstructive lung disease (HP:0006536)2.09537571
75Abnormal hair laboratory examination (HP:0003328)2.08934296
76Abnormality of male internal genitalia (HP:0000022)2.08330980
77Ridged nail (HP:0001807)2.07349702
78Xerostomia (HP:0000217)2.05426446
79Plantar hyperkeratosis (HP:0007556)2.05122016
80Elevated erythrocyte sedimentation rate (HP:0003565)2.04556670
81Ankyloglossia (HP:0010296)2.04439716
82Skin ulcer (HP:0200042)2.04263191
83Interstitial pulmonary disease (HP:0006530)2.03643795
84Recurrent skin infections (HP:0001581)2.03303208
85Palmoplantar hyperkeratosis (HP:0000972)1.99059986
86Mediastinal lymphadenopathy (HP:0100721)1.98927818
87Erythema (HP:0010783)1.96014069
88Abnormality of T cell physiology (HP:0011840)1.95668609
89Abnormality of T cell number (HP:0011839)1.93195152
90Neoplasm of the lung (HP:0100526)1.93002294
91Thick nail (HP:0001805)1.91308838
92Panhypogammaglobulinemia (HP:0003139)1.90425735
93Recurrent gram-negative bacterial infections (HP:0005420)1.90157679
94Menorrhagia (HP:0000132)1.89434714
95Restrictive lung disease (HP:0002091)1.89109316
96Chest pain (HP:0100749)1.89018016
97Joint swelling (HP:0001386)1.88114446
98Recurrent cutaneous fungal infections (HP:0011370)1.87724135
99Chronic mucocutaneous candidiasis (HP:0002728)1.87724135
100Abnormality of nail color (HP:0100643)1.86439114

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.07012094
2MST1R4.80287353
3FGFR43.12053746
4TYK22.95064258
5MAP4K12.90977158
6RIPK42.77403803
7RIPK12.64949051
8PIK3CA2.63319891
9EPHA22.58520682
10EPHA32.54114697
11PRPF4B2.34577491
12BLK2.30373561
13EPHB12.23715172
14JAK12.01576249
15FGFR31.75418011
16MET1.75143611
17CDC42BPA1.70712541
18JAK31.70449160
19MAP3K141.67868964
20KIT1.65807998
21ZAP701.64432597
22IKBKE1.54931285
23GRK61.38682896
24ACVR1B1.36415031
25CSK1.35678666
26STK241.31684639
27LMTK21.28876868
28TBK11.28629740
29EPHB21.26612808
30MAP3K11.23787864
31IRAK41.19844304
32SMG11.19727871
33SYK1.18385014
34FES1.14900091
35FER1.13031262
36BTK1.11782983
37LYN1.10721933
38MAP3K101.10275096
39TRIB31.09437588
40CSF1R1.09185493
41SIK31.08858700
42TXK1.08654978
43IRAK11.08492038
44MATK1.07176976
45JAK21.06603398
46MAP3K131.03634297
47PDGFRA0.99138380
48DDR20.99073177
49NLK0.95571222
50MYLK0.94723537
51TAOK10.93363790
52HCK0.90999363
53PKN20.87629017
54BMPR20.86043561
55PTK60.84655373
56BMX0.81990869
57PRKG20.80283043
58IKBKB0.78705359
59MAP3K30.77454215
60RET0.75931597
61FGR0.67277499
62MAPK70.66745223
63LCK0.65102464
64HIPK20.63550949
65TESK20.62416189
66PDPK10.60123974
67LRRK20.56719297
68FYN0.56023793
69TAOK30.55576311
70PDGFRB0.54875245
71MAPK110.54212358
72TGFBR20.51461993
73PDK10.51406126
74MAP2K30.50949809
75YES10.50794208
76GRK50.50706239
77TEC0.50512194
78ITK0.49904587
79STK390.49737457
80MAPKAPK20.48917186
81TGFBR10.48513850
82MAP3K110.48119649
83DMPK0.47273145
84NEK90.44625230
85KSR20.44577300
86MAP3K20.44366381
87MAP3K60.43412309
88MAP3K120.42458765
89MST40.42328382
90NME10.41677333
91OXSR10.40871428
92SIK10.39519265
93MAP2K60.37716006
94SRC0.37082278
95TAOK20.36158709
96PRKD20.35469019
97IGF1R0.32894086
98PRKCQ0.31323454
99PRKCD0.29319910
100PAK40.28638064

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.34746262
2Asthma_Homo sapiens_hsa053103.19527031
3Allograft rejection_Homo sapiens_hsa053303.13516053
4Autoimmune thyroid disease_Homo sapiens_hsa053203.03562171
5Graft-versus-host disease_Homo sapiens_hsa053322.97567786
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.83556192
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.62432373
8Leishmaniasis_Homo sapiens_hsa051402.45282234
9Type I diabetes mellitus_Homo sapiens_hsa049402.35238908
10Antigen processing and presentation_Homo sapiens_hsa046122.13826233
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.11549736
12Cyanoamino acid metabolism_Homo sapiens_hsa004601.94137786
13Arginine biosynthesis_Homo sapiens_hsa002201.89288259
14Viral myocarditis_Homo sapiens_hsa054161.82611739
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.80953911
16Primary immunodeficiency_Homo sapiens_hsa053401.79235610
17Toxoplasmosis_Homo sapiens_hsa051451.61127681
18Pertussis_Homo sapiens_hsa051331.61125997
19Sulfur metabolism_Homo sapiens_hsa009201.60765572
20Hematopoietic cell lineage_Homo sapiens_hsa046401.48635445
21Influenza A_Homo sapiens_hsa051641.40391149
22Osteoclast differentiation_Homo sapiens_hsa043801.38247911
23Tuberculosis_Homo sapiens_hsa051521.32889553
24B cell receptor signaling pathway_Homo sapiens_hsa046621.27857690
25Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.23056411
26Renin-angiotensin system_Homo sapiens_hsa046141.21892062
27Fat digestion and absorption_Homo sapiens_hsa049751.17829027
28Other glycan degradation_Homo sapiens_hsa005111.16684413
29Fructose and mannose metabolism_Homo sapiens_hsa000511.15038383
30Rheumatoid arthritis_Homo sapiens_hsa053231.14304884
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.11276364
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.08167810
33Complement and coagulation cascades_Homo sapiens_hsa046101.08032840
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.07890534
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05275364
36Herpes simplex infection_Homo sapiens_hsa051681.03343583
37Chemokine signaling pathway_Homo sapiens_hsa040621.03117079
38Hepatitis C_Homo sapiens_hsa051601.02945086
39Phagosome_Homo sapiens_hsa041450.99923006
40TNF signaling pathway_Homo sapiens_hsa046680.95037749
41Caffeine metabolism_Homo sapiens_hsa002320.94986356
42Nitrogen metabolism_Homo sapiens_hsa009100.90409754
43Arachidonic acid metabolism_Homo sapiens_hsa005900.88961858
44Measles_Homo sapiens_hsa051620.88894064
45Mineral absorption_Homo sapiens_hsa049780.88831120
46Toll-like receptor signaling pathway_Homo sapiens_hsa046200.88517138
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.88224685
48Pancreatic secretion_Homo sapiens_hsa049720.86733573
49Amoebiasis_Homo sapiens_hsa051460.84238100
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83534979
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.83196052
52Platelet activation_Homo sapiens_hsa046110.81403919
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81026391
54Malaria_Homo sapiens_hsa051440.77072865
55Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.74025036
56African trypanosomiasis_Homo sapiens_hsa051430.71549203
57Salmonella infection_Homo sapiens_hsa051320.69677109
58Histidine metabolism_Homo sapiens_hsa003400.69436734
59Protein digestion and absorption_Homo sapiens_hsa049740.67507245
60Thyroid hormone synthesis_Homo sapiens_hsa049180.66677454
61Acute myeloid leukemia_Homo sapiens_hsa052210.66177157
62Jak-STAT signaling pathway_Homo sapiens_hsa046300.64970477
63Linoleic acid metabolism_Homo sapiens_hsa005910.64832620
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62907288
65Galactose metabolism_Homo sapiens_hsa000520.60515485
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60423028
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57895645
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57831167
69Starch and sucrose metabolism_Homo sapiens_hsa005000.55509318
70Arginine and proline metabolism_Homo sapiens_hsa003300.55057166
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54866178
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54626183
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53434765
74Apoptosis_Homo sapiens_hsa042100.53270156
75T cell receptor signaling pathway_Homo sapiens_hsa046600.53268349
76RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53084907
77HIF-1 signaling pathway_Homo sapiens_hsa040660.52865163
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.52567230
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51440834
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50797629
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49293289
82Pancreatic cancer_Homo sapiens_hsa052120.46102600
83PPAR signaling pathway_Homo sapiens_hsa033200.44084195
84Retinol metabolism_Homo sapiens_hsa008300.43027591
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42630058
86Hepatitis B_Homo sapiens_hsa051610.40262893
87Prion diseases_Homo sapiens_hsa050200.40042076
88Legionellosis_Homo sapiens_hsa051340.39913477
89Ether lipid metabolism_Homo sapiens_hsa005650.38749601
90Lysosome_Homo sapiens_hsa041420.38374455
91Systemic lupus erythematosus_Homo sapiens_hsa053220.37799267
92Prolactin signaling pathway_Homo sapiens_hsa049170.37732461
93Shigellosis_Homo sapiens_hsa051310.34523840
94Small cell lung cancer_Homo sapiens_hsa052220.33357958
95VEGF signaling pathway_Homo sapiens_hsa043700.33107732
96GnRH signaling pathway_Homo sapiens_hsa049120.31329980
97HTLV-I infection_Homo sapiens_hsa051660.30695644
98Glycerolipid metabolism_Homo sapiens_hsa005610.30679764
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30446973
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.30254311

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