IGFBP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of fibrinolysis (GO:0051918)6.39436398
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.86200335
3L-phenylalanine metabolic process (GO:0006558)5.86200335
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.82064196
5L-phenylalanine catabolic process (GO:0006559)5.82064196
6regulation of fibrinolysis (GO:0051917)5.63455594
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.47353643
8planar cell polarity pathway involved in neural tube closure (GO:0090179)5.38317573
9alpha-linolenic acid metabolic process (GO:0036109)5.35593546
10glyoxylate metabolic process (GO:0046487)5.17088064
11aromatic amino acid family catabolic process (GO:0009074)5.07723045
12sulfur amino acid catabolic process (GO:0000098)4.98143449
13regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.95059478
14high-density lipoprotein particle remodeling (GO:0034375)4.82016590
15negative regulation of sterol transport (GO:0032372)4.80178406
16negative regulation of cholesterol transport (GO:0032375)4.80178406
17kynurenine metabolic process (GO:0070189)4.72562618
18serine family amino acid catabolic process (GO:0009071)4.70041450
19regulation of protein activation cascade (GO:2000257)4.68457984
20bile acid biosynthetic process (GO:0006699)4.65465920
21protein carboxylation (GO:0018214)4.61259472
22peptidyl-glutamic acid carboxylation (GO:0017187)4.61259472
23glycine metabolic process (GO:0006544)4.57246340
24urea metabolic process (GO:0019627)4.53753079
25urea cycle (GO:0000050)4.53753079
26epoxygenase P450 pathway (GO:0019373)4.51141580
27cysteine metabolic process (GO:0006534)4.45641056
28tryptophan catabolic process (GO:0006569)4.40911634
29indole-containing compound catabolic process (GO:0042436)4.40911634
30indolalkylamine catabolic process (GO:0046218)4.40911634
31regulation of complement activation (GO:0030449)4.39584944
32reverse cholesterol transport (GO:0043691)4.28105040
33complement activation, alternative pathway (GO:0006957)4.24779450
34camera-type eye morphogenesis (GO:0048593)4.23666626
35convergent extension (GO:0060026)4.15220233
36tryptophan metabolic process (GO:0006568)4.14593488
37regulation of cholesterol esterification (GO:0010872)4.14425702
38lateral sprouting from an epithelium (GO:0060601)4.08640322
39nitrogen cycle metabolic process (GO:0071941)4.08145171
40regulation of plasminogen activation (GO:0010755)4.07719375
41homocysteine metabolic process (GO:0050667)4.06193304
42plasma lipoprotein particle remodeling (GO:0034369)4.01097675
43protein-lipid complex remodeling (GO:0034368)4.01097675
44macromolecular complex remodeling (GO:0034367)4.01097675
45serine family amino acid biosynthetic process (GO:0009070)3.93505576
46lysine catabolic process (GO:0006554)3.92133276
47lysine metabolic process (GO:0006553)3.92133276
48bile acid metabolic process (GO:0008206)3.91956635
49imidazole-containing compound metabolic process (GO:0052803)3.91517956
50serine family amino acid metabolic process (GO:0009069)3.91253785
51plasma lipoprotein particle clearance (GO:0034381)3.91203601
52cellular modified amino acid catabolic process (GO:0042219)3.80743282
53midgut development (GO:0007494)3.78746980
54Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.78424972
55alpha-amino acid catabolic process (GO:1901606)3.76373420
56fibrinolysis (GO:0042730)3.74858540
57phospholipid efflux (GO:0033700)3.69463664
58amino-acid betaine metabolic process (GO:0006577)3.65198279
59aromatic amino acid family metabolic process (GO:0009072)3.63969168
60establishment of tissue polarity (GO:0007164)3.63444823
61establishment of planar polarity (GO:0001736)3.63444823
62regulation of triglyceride catabolic process (GO:0010896)3.62271058
63pyrimidine nucleobase catabolic process (GO:0006208)3.60911489
64positive regulation of fatty acid beta-oxidation (GO:0032000)3.60452116
65G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.59420886
66regulation of establishment of planar polarity (GO:0090175)3.59045810
67triglyceride homeostasis (GO:0070328)3.58812463
68acylglycerol homeostasis (GO:0055090)3.58812463
69axon extension involved in axon guidance (GO:0048846)3.58374994
70neuron projection extension involved in neuron projection guidance (GO:1902284)3.58374994
71tyrosine metabolic process (GO:0006570)3.58347091
72dicarboxylic acid biosynthetic process (GO:0043650)3.54548287
73coenzyme catabolic process (GO:0009109)3.53490537
74apical protein localization (GO:0045176)3.53192731
75cholesterol efflux (GO:0033344)3.50942045
76cellular amino acid catabolic process (GO:0009063)3.50850091
77axonemal dynein complex assembly (GO:0070286)3.49961733
78regulation of cholesterol homeostasis (GO:2000188)3.49283518
79glutamate metabolic process (GO:0006536)3.48910515
80fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.46907484
81plasma lipoprotein particle assembly (GO:0034377)3.46478426
82arginine metabolic process (GO:0006525)3.45641736
83cellular ketone body metabolic process (GO:0046950)3.43871938
84protein retention in ER lumen (GO:0006621)3.43032515
85establishment of apical/basal cell polarity (GO:0035089)3.42146129
86neuronal stem cell maintenance (GO:0097150)3.41009970
87paraxial mesoderm development (GO:0048339)3.38411398
88establishment or maintenance of bipolar cell polarity (GO:0061245)3.34815178
89establishment or maintenance of apical/basal cell polarity (GO:0035088)3.34815178
90non-canonical Wnt signaling pathway (GO:0035567)3.33755987
91axonal fasciculation (GO:0007413)3.23522153
92cell migration in hindbrain (GO:0021535)3.23440699
93establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.22579017
94outer ear morphogenesis (GO:0042473)3.20040814
95establishment or maintenance of monopolar cell polarity (GO:0061339)3.18112266
96establishment of monopolar cell polarity (GO:0061162)3.18112266
97positive regulation of lipid catabolic process (GO:0050996)3.17923854
98regulation of fatty acid beta-oxidation (GO:0031998)3.17163739
99L-serine metabolic process (GO:0006563)3.16523309
100maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.15090887
101protein-lipid complex assembly (GO:0065005)3.14066242
102one-carbon metabolic process (GO:0006730)3.11835766
103lung epithelium development (GO:0060428)3.11556100
104lipoprotein metabolic process (GO:0042157)3.11332773
105regulation of hippo signaling (GO:0035330)3.10380379
106aldehyde catabolic process (GO:0046185)3.10295964
107ethanol oxidation (GO:0006069)3.10231678
108blood coagulation, intrinsic pathway (GO:0007597)3.09876751
109low-density lipoprotein particle remodeling (GO:0034374)3.08190693
110glutamine family amino acid biosynthetic process (GO:0009084)3.07811335
111bile acid and bile salt transport (GO:0015721)3.06117990
112cholesterol homeostasis (GO:0042632)3.03802167
113regulation of axon extension involved in axon guidance (GO:0048841)3.02853651
114neuron recognition (GO:0008038)3.02262239
115cellular glucuronidation (GO:0052695)2.99987433
116lens fiber cell development (GO:0070307)2.99918483
117cochlea morphogenesis (GO:0090103)2.99588492
118sterol homeostasis (GO:0055092)2.98941090
119mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.98477858
120negative regulation of chondrocyte differentiation (GO:0032331)2.97938084
121plasma lipoprotein particle organization (GO:0071827)2.97506912
122negative regulation of fatty acid biosynthetic process (GO:0045717)2.96335850
123negative regulation of protein activation cascade (GO:2000258)2.95776133
124eye morphogenesis (GO:0048592)2.95443040
125benzene-containing compound metabolic process (GO:0042537)2.95236920
126negative regulation of lipase activity (GO:0060192)2.92819900
127indolalkylamine metabolic process (GO:0006586)2.92099892
128linoleic acid metabolic process (GO:0043651)2.92071463
129lung-associated mesenchyme development (GO:0060484)2.90802320
130acetyl-CoA metabolic process (GO:0006084)2.90264080
131positive regulation of hemostasis (GO:1900048)2.90254141
132positive regulation of blood coagulation (GO:0030194)2.90254141
133left/right pattern formation (GO:0060972)2.90122287
134ketone body metabolic process (GO:1902224)2.89729475
135dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.88639287
136response to nitrosative stress (GO:0051409)2.87958494
137negative regulation of lipid transport (GO:0032369)2.87834161
138semaphorin-plexin signaling pathway (GO:0071526)2.86188806
139notochord development (GO:0030903)2.86071453
140cell surface receptor signaling pathway involved in heart development (GO:0061311)2.85125918
141embryonic camera-type eye development (GO:0031076)2.82842882
142embryonic retina morphogenesis in camera-type eye (GO:0060059)2.80316198
143nucleobase catabolic process (GO:0046113)2.79959650
144asymmetric protein localization (GO:0008105)2.77751479
145body morphogenesis (GO:0010171)2.77088510
146endothelial cell chemotaxis (GO:0035767)2.76319170
147regulation of axon guidance (GO:1902667)2.76108199
148regulation of cell fate specification (GO:0042659)2.74963645
149ear development (GO:0043583)2.74187470
150presynaptic membrane assembly (GO:0097105)2.71362106
151mesenchymal to epithelial transition (GO:0060231)2.71124000
152negative regulation of catenin import into nucleus (GO:0035414)2.70331908
153postsynaptic membrane organization (GO:0001941)2.67218267
154spinal cord development (GO:0021510)2.64189067
155negative regulation of cell fate specification (GO:0009996)2.62573622
156axon extension (GO:0048675)2.61640880
157calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.60952245
158positive regulation of smoothened signaling pathway (GO:0045880)2.59420398
159renal system development (GO:0072001)2.58208832
160nucleosome disassembly (GO:0006337)2.56954259
161protein-DNA complex disassembly (GO:0032986)2.56954259
162positive regulation of neuroblast proliferation (GO:0002052)2.54736244
163cellular response to prostaglandin stimulus (GO:0071379)2.53659727
164somatic stem cell division (GO:0048103)2.53495940
165neural tube development (GO:0021915)2.52880058
166branching involved in salivary gland morphogenesis (GO:0060445)2.52136460
167regulation of catenin import into nucleus (GO:0035412)2.50652665
168protein heterotrimerization (GO:0070208)2.49696554
169collagen fibril organization (GO:0030199)2.48343543
170embryonic body morphogenesis (GO:0010172)2.47925321
171presynaptic membrane organization (GO:0097090)2.45390308
172cilium movement (GO:0003341)2.43809027
173cell migration involved in sprouting angiogenesis (GO:0002042)2.42732632
174basement membrane organization (GO:0071711)2.42560684
175Notch signaling involved in heart development (GO:0061314)2.40208937
176negative regulation of axon extension involved in axon guidance (GO:0048843)2.38861257
177ephrin receptor signaling pathway (GO:0048013)2.36428182
178lens morphogenesis in camera-type eye (GO:0002089)2.34789552
179post-anal tail morphogenesis (GO:0036342)2.34336547
180negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.33350350
181layer formation in cerebral cortex (GO:0021819)2.32523461
182spinal cord association neuron differentiation (GO:0021527)2.31952899
183ganglion development (GO:0061548)2.29718978
184establishment of nucleus localization (GO:0040023)2.29399734
1854-hydroxyproline metabolic process (GO:0019471)2.29392798
186cell-cell junction maintenance (GO:0045217)2.28081780
187epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.27603104
188morphogenesis of an epithelial sheet (GO:0002011)2.25630230
189myelination in peripheral nervous system (GO:0022011)2.24694066
190peripheral nervous system axon ensheathment (GO:0032292)2.24694066
191neuron remodeling (GO:0016322)2.24671441
192dorsal/ventral axis specification (GO:0009950)2.23877469
193negative regulation of cartilage development (GO:0061037)2.23619661
194tongue development (GO:0043586)2.23271221
195motile cilium assembly (GO:0044458)2.23144780

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.26917543
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.67632597
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.93178978
4* LXR_22158963_ChIP-Seq_LIVER_Mouse4.18199660
5EGR1_23403033_ChIP-Seq_LIVER_Mouse3.64174458
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.54580337
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.26365706
8EZH2_22144423_ChIP-Seq_EOC_Human2.93155304
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.92717450
10ESR1_15608294_ChIP-ChIP_MCF-7_Human2.92196463
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.90192290
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.74544548
13* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.73440895
14* NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.54559580
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.50465219
16TCF3_18692474_ChIP-Seq_MEFs_Mouse2.42334025
17CLOCK_20551151_ChIP-Seq_293T_Human2.34926705
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.27852759
19KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.25013201
20KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.25013201
21KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.25013201
22ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.22530594
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.19233449
24CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.15939615
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.13236927
26EZH2_18974828_ChIP-Seq_MESCs_Mouse2.08955958
27RNF2_18974828_ChIP-Seq_MESCs_Mouse2.08955958
28SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.08190762
29EZH2_27304074_Chip-Seq_ESCs_Mouse2.01490614
30* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.99952890
31PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.97417158
32FOXM1_23109430_ChIP-Seq_U2OS_Human1.94297876
33* RNF2_27304074_Chip-Seq_ESCs_Mouse1.93453901
34* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.91064887
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.90163315
36* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.89964834
37SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.89503167
38STAT3_1855785_ChIP-Seq_MESCs_Mouse1.85927840
39* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.84731744
40ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.82040643
41SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76516304
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.74863918
43ZNF263_19887448_ChIP-Seq_K562_Human1.74545510
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.74198675
45* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.73750227
46TCF3_18692474_ChIP-Seq_MESCs_Mouse1.73108076
47RING1B_27294783_Chip-Seq_ESCs_Mouse1.72558503
48KDM2B_26808549_Chip-Seq_K562_Human1.69774996
49JARID2_20064375_ChIP-Seq_MESCs_Mouse1.68567171
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.65653687
51POU5F1_16518401_ChIP-PET_MESCs_Mouse1.65098479
52TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.61887928
53JARID2_20075857_ChIP-Seq_MESCs_Mouse1.61307588
54TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.58385913
55* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.54345602
56TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.53640490
57* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.52963151
58CTCF_27219007_Chip-Seq_Bcells_Human1.52924919
59* RING1B_27294783_Chip-Seq_NPCs_Mouse1.51018638
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.49945514
61ISL1_27105846_Chip-Seq_CPCs_Mouse1.47751643
62HIF1A_21447827_ChIP-Seq_MCF-7_Human1.44943449
63SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.40205004
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.39142430
65KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.37843151
66TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.36904775
67TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36646417
68* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.36425151
69SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.36407036
70SOX2_18555785_ChIP-Seq_MESCs_Mouse1.34487127
71DROSHA_22980978_ChIP-Seq_HELA_Human1.34402466
72* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.33966568
73EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.33792542
74RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.32749959
75SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.32110001
76PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.31247188
77HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.30494073
78* RBPJ_22232070_ChIP-Seq_NCS_Mouse1.28570485
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28239002
80SOX3_22085726_ChIP-Seq_NPCs_Mouse1.26712439
81KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25358924
82* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.24364365
83ERG_21242973_ChIP-ChIP_JURKAT_Human1.24320639
84SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.24246247
85E2F7_22180533_ChIP-Seq_HELA_Human1.24234191
86SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.22528537
87LXR_22292898_ChIP-Seq_THP-1_Human1.21095832
88* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.19289233
89CBX2_27304074_Chip-Seq_ESCs_Mouse1.18076019
90ESR2_21235772_ChIP-Seq_MCF-7_Human1.17845374
91RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17559399
92MTF2_20144788_ChIP-Seq_MESCs_Mouse1.14133971
93DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.13574087
94MYC_18555785_ChIP-Seq_MESCs_Mouse1.13434347
95* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.12856980
96AR_21909140_ChIP-Seq_LNCAP_Human1.11209333
97TP53_20018659_ChIP-ChIP_R1E_Mouse1.10833632
98TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10517654
99MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.09092553
100* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.07604351
101DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06635903
102RACK7_27058665_Chip-Seq_MCF-7_Human1.06354685
103FOXA2_19822575_ChIP-Seq_HepG2_Human1.05835098
104ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05259003
105NANOG_18555785_ChIP-Seq_MESCs_Mouse1.04920878
106POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04775618
107* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04012950
108POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03418308
109ELK3_25401928_ChIP-Seq_HUVEC_Human1.03405991
110WT1_19549856_ChIP-ChIP_CCG9911_Human1.02283137
111CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01619330
112P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01406501
113* NANOG_16518401_ChIP-PET_MESCs_Mouse0.98553764
114* SOX2_16153702_ChIP-ChIP_HESCs_Human0.98310280
115SMC4_20622854_ChIP-Seq_HELA_Human0.97941753
116EGR1_19374776_ChIP-ChIP_THP-1_Human0.97880233
117* MYC_19079543_ChIP-ChIP_MESCs_Mouse0.97831877
118SALL4_18804426_ChIP-ChIP_XEN_Mouse0.97017245
119SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96013949
120WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95442444
121* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.94340999
122ATF3_27146783_Chip-Seq_COLON_Human0.94306881
123* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93425538
124ESR1_21235772_ChIP-Seq_MCF-7_Human0.93264682
125* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.92506302
126* HNF4A_19822575_ChIP-Seq_HepG2_Human0.91943110
127TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89421140
128SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.88379769
129THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87957707
130NANOG_21062744_ChIP-ChIP_HESCs_Human0.87657957
131NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.86273959
132UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.85492635
133KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.85460662
134* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.85096046
135EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.84972442
136* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.84712026
137* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.84440068
138* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.84191724
139TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83008803
140* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.80636512
141KLF4_18555785_ChIP-Seq_MESCs_Mouse0.80276184
142* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.79520972
143* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.78370687
144ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.77429276
145ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.77140597
146TP53_22127205_ChIP-Seq_IMR90_Human0.75852590
147CREB1_26743006_Chip-Seq_LNCaP_Human0.74936708
148FOXO3_23340844_ChIP-Seq_DLD1_Human0.74078676
149* NANOG_16153702_ChIP-ChIP_HESCs_Human0.73392534

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.05581003
2MP0005360_urolithiasis5.66701946
3MP0005085_abnormal_gallbladder_physiolo4.74555286
4MP0005365_abnormal_bile_salt4.41872517
5MP0003806_abnormal_nucleotide_metabolis3.94399284
6MP0008875_abnormal_xenobiotic_pharmacok3.39099652
7MP0003705_abnormal_hypodermis_morpholog3.15705319
8MP0003122_maternal_imprinting3.08867711
9MP0003252_abnormal_bile_duct2.97486556
10MP0003283_abnormal_digestive_organ2.90544240
11MP0009053_abnormal_anal_canal2.77386875
12MP0009840_abnormal_foam_cell2.60534095
13MP0010329_abnormal_lipoprotein_level2.59006437
14MP0005377_hearing/vestibular/ear_phenot2.29162078
15MP0003878_abnormal_ear_physiology2.29162078
16MP0000778_abnormal_nervous_system2.24335099
17MP0005083_abnormal_biliary_tract2.18931692
18MP0000049_abnormal_middle_ear2.16288940
19MP0008438_abnormal_cutaneous_collagen2.14180951
20MP0010030_abnormal_orbit_morphology2.01675390
21MP0005332_abnormal_amino_acid1.93085279
22MP0004859_abnormal_synaptic_plasticity1.79864098
23MP0005499_abnormal_olfactory_system1.75196883
24MP0005394_taste/olfaction_phenotype1.75196883
25MP0010352_gastrointestinal_tract_polyps1.70829065
26MP0002653_abnormal_ependyma_morphology1.69868299
27MP0008789_abnormal_olfactory_epithelium1.67334102
28MP0001666_abnormal_nutrient_absorption1.64509808
29MP0004133_heterotaxia1.64433494
30MP0003121_genomic_imprinting1.58221723
31MP0002249_abnormal_larynx_morphology1.55670330
32MP0003191_abnormal_cellular_cholesterol1.55311321
33MP0003123_paternal_imprinting1.53439340
34MP0003566_abnormal_cell_adhesion1.47918425
35MP0002254_reproductive_system_inflammat1.47319926
36MP0009379_abnormal_foot_pigmentation1.46576321
37MP0000609_abnormal_liver_physiology1.46365999
38MP0006292_abnormal_olfactory_placode1.44986583
39MP0001299_abnormal_eye_distance/1.44951964
40MP0003861_abnormal_nervous_system1.41912264
41MP0000762_abnormal_tongue_morphology1.41692761
42MP0004019_abnormal_vitamin_homeostasis1.40851129
43MP0003195_calcinosis1.38304827
44MP0002282_abnormal_trachea_morphology1.38091020
45MP0003119_abnormal_digestive_system1.36205476
46MP0003938_abnormal_ear_development1.35404125
47MP0002116_abnormal_craniofacial_bone1.33753414
48MP0000537_abnormal_urethra_morphology1.33410939
49MP0003868_abnormal_feces_composition1.27323418
50MP0002118_abnormal_lipid_homeostasis1.26843437
51MP0000467_abnormal_esophagus_morphology1.24395236
52MP0003942_abnormal_urinary_system1.23068755
53MP0005319_abnormal_enzyme/_coenzyme1.22675122
54MP0003115_abnormal_respiratory_system1.18893071
55MP0004272_abnormal_basement_membrane1.18889054
56MP0005623_abnormal_meninges_morphology1.18855976
57MP0000955_abnormal_spinal_cord1.17945435
58MP0001984_abnormal_olfaction1.17517457
59MP0005275_abnormal_skin_tensile1.17058565
60MP0003136_yellow_coat_color1.14757131
61MP0004885_abnormal_endolymph1.14212310
62MP0000678_abnormal_parathyroid_gland1.12502797
63MP0002697_abnormal_eye_size1.11151753
64MP0001293_anophthalmia1.11077031
65MP0005023_abnormal_wound_healing1.10244173
66MP0005076_abnormal_cell_differentiation1.08043127
67MP0003890_abnormal_embryonic-extraembry1.06232437
68MP0001915_intracranial_hemorrhage1.06157233
69MP0000026_abnormal_inner_ear1.05668780
70MP0010368_abnormal_lymphatic_system1.05435163
71MP0005503_abnormal_tendon_morphology1.03561195
72MP0002092_abnormal_eye_morphology1.03040933
73MP0009384_cardiac_valve_regurgitation1.01355809
74MP0002152_abnormal_brain_morphology1.01097294
75MP0009250_abnormal_appendicular_skeleto1.01052509
76MP0005248_abnormal_Harderian_gland0.98367981
77MP0002938_white_spotting0.98169687
78MP0003011_delayed_dark_adaptation0.97981617
79MP0002184_abnormal_innervation0.97728004
80MP0000534_abnormal_ureter_morphology0.95240895
81MP0004197_abnormal_fetal_growth/weight/0.94890860
82MP0005197_abnormal_uvea_morphology0.94548510
83* MP0000598_abnormal_liver_morphology0.94456513
84MP0002932_abnormal_joint_morphology0.94113377
85MP0002108_abnormal_muscle_morphology0.93848709
86MP0002111_abnormal_tail_morphology0.92623419
87MP0003279_aneurysm0.91735261
88MP0001879_abnormal_lymphatic_vessel0.91102539
89MP0002081_perinatal_lethality0.87768988
90MP0005409_darkened_coat_color0.87234624
91MP0002909_abnormal_adrenal_gland0.84579440
92MP0002233_abnormal_nose_morphology0.82997839
93MP0001849_ear_inflammation0.82600789
94MP0003567_abnormal_fetal_cardiomyocyte0.82591455
95MP0004270_analgesia0.82566643
96MP0003787_abnormal_imprinting0.82457000
97MP0001502_abnormal_circadian_rhythm0.81310276
98MP0005508_abnormal_skeleton_morphology0.79107458
99MP0000579_abnormal_nail_morphology0.78442561
100MP0002557_abnormal_social/conspecific_i0.78352167
101MP0002084_abnormal_developmental_patter0.78325557
102MP0002114_abnormal_axial_skeleton0.77755534
103MP0003385_abnormal_body_wall0.76890568
104MP0002295_abnormal_pulmonary_circulatio0.76756967
105MP0002234_abnormal_pharynx_morphology0.76633618
106MP0005584_abnormal_enzyme/coenzyme_acti0.76152640
107MP0000462_abnormal_digestive_system0.75133487
108MP0002896_abnormal_bone_mineralization0.74623545
109MP0002085_abnormal_embryonic_tissue0.74449131
110MP0002751_abnormal_autonomic_nervous0.74439383
111MP0003091_abnormal_cell_migration0.74149926
112MP0000604_amyloidosis0.73842808
113MP0002882_abnormal_neuron_morphology0.73409626
114MP0004858_abnormal_nervous_system0.73355494
115MP0002138_abnormal_hepatobiliary_system0.72596552
116MP0003634_abnormal_glial_cell0.72520036
117MP0005391_vision/eye_phenotype0.72457514
118MP0000428_abnormal_craniofacial_morphol0.71638139
119MP0001286_abnormal_eye_development0.71457711
120MP0001348_abnormal_lacrimal_gland0.71249692
121MP0005193_abnormal_anterior_eye0.70348825
122MP0002752_abnormal_somatic_nervous0.69324469
123MP0005220_abnormal_exocrine_pancreas0.69217994
124MP0001346_abnormal_lacrimal_gland0.68924864
125MP0002089_abnormal_postnatal_growth/wei0.68769819
126MP0005670_abnormal_white_adipose0.68039146
127MP0000566_synostosis0.67811542
128MP0001730_embryonic_growth_arrest0.67718788
129MP0003755_abnormal_palate_morphology0.67556605
130MP0001243_abnormal_dermal_layer0.67179589
131MP0003941_abnormal_skin_development0.66825006
132MP0005187_abnormal_penis_morphology0.66809070
133MP0005380_embryogenesis_phenotype0.66808516
134MP0001672_abnormal_embryogenesis/_devel0.66808516
135MP0002086_abnormal_extraembryonic_tissu0.66459419
136MP0005266_abnormal_metabolism0.66382215
137MP0003186_abnormal_redox_activity0.66085577
138MP0004883_abnormal_blood_vessel0.65666723
139MP0003937_abnormal_limbs/digits/tail_de0.65451843
140MP0008932_abnormal_embryonic_tissue0.65269001
141MP0003935_abnormal_craniofacial_develop0.63262268
142MP0005257_abnormal_intraocular_pressure0.62764203
143MP0009672_abnormal_birth_weight0.62410465
144MP0003329_amyloid_beta_deposits0.60573660
145MP0000767_abnormal_smooth_muscle0.60360534
146MP0002088_abnormal_embryonic_growth/wei0.59931993
147MP0010234_abnormal_vibrissa_follicle0.59526554
148MP0000432_abnormal_head_morphology0.59403101
149MP0003984_embryonic_growth_retardation0.59297658
150MP0003453_abnormal_keratinocyte_physiol0.58870958

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.66675047
2Abnormality of monocarboxylic acid metabolism (HP:0010996)5.83611869
3Intrahepatic cholestasis (HP:0001406)5.76693222
4Abnormality of aromatic amino acid family metabolism (HP:0004338)5.28177285
5Hypobetalipoproteinemia (HP:0003563)5.07362777
6Xanthomatosis (HP:0000991)4.98497921
7Prolonged partial thromboplastin time (HP:0003645)4.28859773
8Hypolipoproteinemia (HP:0010981)4.03169021
9Complement deficiency (HP:0004431)3.94043822
10Hyperlipoproteinemia (HP:0010980)3.91623162
11Protrusio acetabuli (HP:0003179)3.85127388
12Hypoalphalipoproteinemia (HP:0003233)3.78133166
13Spastic diplegia (HP:0001264)3.60565368
14Epidermoid cyst (HP:0200040)3.58100625
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.41696008
16Hyperammonemia (HP:0001987)3.41241057
17Hyperglycinemia (HP:0002154)3.35234329
18Abnormality of pyrimidine metabolism (HP:0004353)3.35145542
19Abnormality of the common coagulation pathway (HP:0010990)3.34429412
20Abnormality of glutamine family amino acid metabolism (HP:0010902)3.31923709
21Abnormality of sulfur amino acid metabolism (HP:0004339)3.29711481
22Vitreoretinal degeneration (HP:0000655)3.23754567
23Neonatal short-limb short stature (HP:0008921)3.18686239
24Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.18278799
25Back pain (HP:0003418)3.15493446
26Abnormality of methionine metabolism (HP:0010901)3.08190806
27Abnormality of complement system (HP:0005339)3.00635912
28Joint hemorrhage (HP:0005261)2.89370140
29Hyperglycinuria (HP:0003108)2.86429080
30Ketosis (HP:0001946)2.80782167
31Abnormality of serine family amino acid metabolism (HP:0010894)2.80764156
32Abnormality of glycine metabolism (HP:0010895)2.80764156
33Atrophic scars (HP:0001075)2.80349794
34Premature rupture of membranes (HP:0001788)2.79881443
35Abnormality of aspartate family amino acid metabolism (HP:0010899)2.78433055
36Pseudobulbar signs (HP:0002200)2.77419423
37Peritonitis (HP:0002586)2.76260749
38Fat malabsorption (HP:0002630)2.74385054
39Shallow orbits (HP:0000586)2.71252750
40Malnutrition (HP:0004395)2.68052719
41Abnormality of the intrinsic pathway (HP:0010989)2.67094274
42Delayed CNS myelination (HP:0002188)2.64329932
43Hepatocellular carcinoma (HP:0001402)2.54952034
44Turricephaly (HP:0000262)2.52131074
45Hepatoblastoma (HP:0002884)2.52009111
46Aplasia involving bones of the extremities (HP:0009825)2.52005990
47Aplasia involving bones of the upper limbs (HP:0009823)2.52005990
48Aplasia of the phalanges of the hand (HP:0009802)2.52005990
49Ulnar bowing (HP:0003031)2.51218152
50Hypercholesterolemia (HP:0003124)2.48246864
51Morphological abnormality of the middle ear (HP:0008609)2.46631376
52Broad metatarsal (HP:0001783)2.46067688
53Skin nodule (HP:0200036)2.40772994
54Hyperacusis (HP:0010780)2.40421475
55Soft skin (HP:0000977)2.37075102
56Broad long bones (HP:0005622)2.37002659
57Abnormal respiratory motile cilium physiology (HP:0012261)2.36110314
58Vertebral arch anomaly (HP:0008438)2.35528648
59Cutaneous syndactyly (HP:0012725)2.34517599
60High anterior hairline (HP:0009890)2.33261573
61Hypochromic microcytic anemia (HP:0004840)2.28999055
62Cutaneous finger syndactyly (HP:0010554)2.27912489
63Abnormal respiratory epithelium morphology (HP:0012253)2.27400961
64Abnormal respiratory motile cilium morphology (HP:0005938)2.27400961
65Thin ribs (HP:0000883)2.26849079
66Abnormality of the Achilles tendon (HP:0005109)2.23591370
67Broad thumb (HP:0011304)2.23251140
68Esophageal varix (HP:0002040)2.23095256
69Bowel diverticulosis (HP:0005222)2.21952190
70Trigonocephaly (HP:0000243)2.19040248
71Rhinitis (HP:0012384)2.17856625
72Hypoglycemic coma (HP:0001325)2.17701367
73Mitral valve prolapse (HP:0001634)2.17410268
74Abnormal cartilage morphology (HP:0002763)2.16906017
75Septo-optic dysplasia (HP:0100842)2.16776651
76Renovascular hypertension (HP:0100817)2.16723052
77Blue sclerae (HP:0000592)2.16374792
78Renal duplication (HP:0000075)2.15164795
79Choanal stenosis (HP:0000452)2.14857560
80Vascular tortuosity (HP:0004948)2.14039658
81Chronic bronchitis (HP:0004469)2.12444306
82Coronal craniosynostosis (HP:0004440)2.11567047
83Broad phalanges of the hand (HP:0009768)2.10339204
84Partial duplication of thumb phalanx (HP:0009944)2.10046990
85Arterial tortuosity (HP:0005116)2.09330222
86Abnormality of nucleobase metabolism (HP:0010932)2.08867372
87Broad phalanx (HP:0006009)2.08738053
88Partial duplication of the phalanx of hand (HP:0009999)2.07488585
89Abnormality of the lower motor neuron (HP:0002366)2.07246544
90Genu recurvatum (HP:0002816)2.06828186
91Abnormal ciliary motility (HP:0012262)2.06406284
92Broad finger (HP:0001500)2.05806938
93Myocardial infarction (HP:0001658)2.04561421
94Overriding aorta (HP:0002623)2.04268488
95Neonatal onset (HP:0003623)2.04259788
96Cortical dysplasia (HP:0002539)2.00513364
97Spontaneous abortion (HP:0005268)1.99724980
98Hyperbilirubinemia (HP:0002904)1.96581027
99Abnormality of the ischium (HP:0003174)1.95350233
100Rib fusion (HP:0000902)1.95253422
101Abnormality of serum amino acid levels (HP:0003112)1.95008633
102Arnold-Chiari malformation (HP:0002308)1.94934399
103Steatorrhea (HP:0002570)1.93680636
104Biconcave vertebral bodies (HP:0004586)1.92676541
105Occipital encephalocele (HP:0002085)1.92545901
106Atelectasis (HP:0100750)1.91701267
107Cerebral aneurysm (HP:0004944)1.91419599
108Abnormality of the calcaneus (HP:0008364)1.90192724
109Vertebral clefting (HP:0008428)1.89614554
110Abnormality of the diencephalon (HP:0010662)1.89453022
111Abnormality of the aortic arch (HP:0012303)1.88872597
112Pterygium (HP:0001059)1.87656726
113Hyperextensible skin (HP:0000974)1.87383546
114Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.86332084
115Elfin facies (HP:0004428)1.85177962
116Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.84902450
117Short 4th metacarpal (HP:0010044)1.84902450
118Bladder diverticulum (HP:0000015)1.84186254
119Hydroxyprolinuria (HP:0003080)1.82752703
120Abnormality of proline metabolism (HP:0010907)1.82752703
121Breech presentation (HP:0001623)1.82523129
122Mitral stenosis (HP:0001718)1.82181209
123Lymphangioma (HP:0100764)1.81699849
124Flat cornea (HP:0007720)1.81100769
125Wide anterior fontanel (HP:0000260)1.80604438
126Cardiovascular calcification (HP:0011915)1.80158890
127Calcaneovalgus deformity (HP:0001848)1.79891318
128Deviation of the hallux (HP:0010051)1.79812488
129Mitral regurgitation (HP:0001653)1.79519763
130Omphalocele (HP:0001539)1.79216214
131Abnormal delivery (HP:0001787)1.77768644
132Aortic dissection (HP:0002647)1.77414726
133Irritability (HP:0000737)1.77134683
134Myelomeningocele (HP:0002475)1.75126556
135Dynein arm defect of respiratory motile cilia (HP:0012255)1.74197860
136Absent/shortened dynein arms (HP:0200106)1.74197860
137Vascular calcification (HP:0004934)1.72914028
138Fragile skin (HP:0001030)1.72117242
139Right ventricular cardiomyopathy (HP:0011663)1.71555994
140Anophthalmia (HP:0000528)1.71228622
141Mixed hearing impairment (HP:0000410)1.71131748
142Midface retrusion (HP:0011800)1.71092916
143Absent epiphyses (HP:0010577)1.70796597
144Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.70796597
145Ectopia lentis (HP:0001083)1.70705961
146Glomerulonephritis (HP:0000099)1.70511869
147Insomnia (HP:0100785)1.70082732
148Fibular hypoplasia (HP:0003038)1.69091738
149Vertebral hypoplasia (HP:0008417)1.68811492
150Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.68811492
151Ankle contracture (HP:0006466)1.68787240
152Broad distal phalanx of finger (HP:0009836)1.67776604
153Increased mean platelet volume (HP:0011877)1.66645091
154Maternal diabetes (HP:0009800)1.65976355
155Bronchomalacia (HP:0002780)1.65896065
156Megalocornea (HP:0000485)1.65420047
157Cholelithiasis (HP:0001081)1.64837279
158Abnormality of the 4th metacarpal (HP:0010012)1.64711947
159Achilles tendon contracture (HP:0001771)1.64532852
160Hypoplastic ischia (HP:0003175)1.64397289
161Bowing of the arm (HP:0006488)1.64127912
162Bowed forearm bones (HP:0003956)1.64127912
163Abnormal gallbladder physiology (HP:0012438)1.63869812
164Cholecystitis (HP:0001082)1.63869812
165Abnormality of fatty-acid metabolism (HP:0004359)1.63728087
166Rickets (HP:0002748)1.63722758
167Nephritis (HP:0000123)1.63706915
168Enlarged penis (HP:0000040)1.63038640
169Infantile muscular hypotonia (HP:0008947)1.60040127
170Abnormality of abdominal situs (HP:0011620)1.59608572
171Abdominal situs inversus (HP:0003363)1.59608572
172Ketoacidosis (HP:0001993)1.59493952
173Abnormal gallbladder morphology (HP:0012437)1.57823755
174Ependymoma (HP:0002888)1.56366678
175Aneurysm (HP:0002617)1.54582885
176Prenatal maternal abnormality (HP:0002686)1.54395863
177Camptodactyly of toe (HP:0001836)1.53600085
178Abnormality of dentin (HP:0010299)1.53381196
179Reticulocytosis (HP:0001923)1.52041464

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.30290436
2SIK13.10958567
3LATS23.04300114
4PKN22.82013616
5EPHB22.70282364
6TRIB32.67676128
7ERN12.52360846
8MAP3K102.44821609
9LATS12.32659328
10SMG12.25082239
11ERBB42.13721568
12MAPK152.12629051
13FGFR42.12482159
14NEK12.02976993
15KSR12.01849825
16CDK121.95552923
17ICK1.87824068
18PDGFRA1.87158589
19TNIK1.86135536
20DDR21.80343582
21TESK21.66887763
22CASK1.63918403
23EPHA21.61981458
24TYRO31.61430136
25MARK11.57904970
26CDK191.50262066
27TTN1.45547884
28DYRK1B1.44983033
29ERBB21.44047628
30PAK21.43467565
31ARAF1.40205842
32PAK41.39589012
33PTK21.39084150
34MTOR1.36823660
35PTK61.34632583
36BUB11.34233591
37FGFR21.33577792
38FGFR11.33090330
39NTRK11.33042686
40RIPK11.31639232
41PAK31.28741509
42BMX1.28663949
43PRKD31.25031162
44EPHA41.23089177
45EEF2K1.16185532
46TIE11.15391812
47MET1.13817618
48PAK61.09817198
49RPS6KB21.08747384
50TESK11.08488598
51MAPKAPK31.07001079
52CDK61.01604655
53RPS6KA20.95423940
54CSNK1G20.95363616
55TTK0.94954906
56FLT30.94670322
57MAP2K70.94652045
58DYRK20.94239653
59UHMK10.92936147
60STK38L0.92418366
61MAP3K80.86705707
62EPHA30.86195587
63BRD40.84628155
64CAMK1G0.81510027
65NTRK20.80362330
66SIK20.76853100
67SCYL20.76836460
68LIMK10.76214282
69AURKA0.75392691
70WEE10.74554700
71LRRK20.74301745
72MAPK110.73590428
73FER0.72655091
74BRAF0.71968502
75CDK70.70956559
76MARK20.70289625
77LMTK20.69702165
78ABL20.69376046
79PRKCZ0.68820904
80MKNK10.68074743
81STK100.67237207
82CDC70.66820537
83TGFBR10.66337816
84KSR20.64944598
85PNCK0.64061979
86DMPK0.63330765
87RPS6KL10.63025894
88RPS6KC10.63025894
89CDK180.61989704
90PDGFRB0.61180044
91CDK150.60244984
92CSNK1G30.60047577
93STK240.59662582
94MOS0.59415764
95CDK40.58456336
96CSNK1G10.57308480
97AKT20.57307907
98ALK0.57073578
99GSK3A0.55871312
100PLK10.55595553
101MINK10.54697266
102CDK140.54326209
103MAP2K20.52766618
104CDK11A0.52727589
105NEK20.52216144
106GRK60.52076066
107CDK50.50784193
108MAP2K40.48983721
109MAP3K40.48010151
110TAOK20.47596055
111PASK0.47569550
112RET0.47115155
113ROCK10.46965714
114DYRK1A0.46918695
115PRKCG0.46777200
116CAMK1D0.46558266
117RPS6KA60.46243114
118PRKCI0.46086372
119CSNK1E0.45299854
120ROCK20.45187734
121DAPK30.44874805
122CHEK20.44456219
123CSNK1A1L0.42601140
124CDC42BPA0.42529540
125CAMKK10.42087537
126DYRK30.42005994
127BCR0.41465603
128SGK4940.41406068
129SGK2230.41406068
130MAPK90.40684882
131ILK0.39767417
132SRC0.39649110
133MAP3K90.39185033
134AURKB0.38468349
135MAP2K10.38391547
136MKNK20.38200624
137DAPK20.38176426
138CSNK1D0.37459411
139TGFBR20.37281001
140PIK3CG0.37094239
141KDR0.37031884
142PAK10.36598968
143MAP3K110.35068242

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.25133983
2Primary bile acid biosynthesis_Homo sapiens_hsa001204.19113394
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.43414297
4Arginine biosynthesis_Homo sapiens_hsa002203.04340898
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.99100548
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.77851631
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.73337724
8Complement and coagulation cascades_Homo sapiens_hsa046102.70223860
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.62833439
10Tryptophan metabolism_Homo sapiens_hsa003802.51013230
11Fatty acid degradation_Homo sapiens_hsa000712.18861730
12Axon guidance_Homo sapiens_hsa043602.13072498
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.98728400
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.96410497
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.94756650
16Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.93818559
17Selenocompound metabolism_Homo sapiens_hsa004501.91181654
18Butanoate metabolism_Homo sapiens_hsa006501.83248797
19Fatty acid metabolism_Homo sapiens_hsa012121.76420506
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.75229936
21Chemical carcinogenesis_Homo sapiens_hsa052041.73831739
22Protein digestion and absorption_Homo sapiens_hsa049741.73563973
23Biosynthesis of amino acids_Homo sapiens_hsa012301.73484346
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.70513969
25PPAR signaling pathway_Homo sapiens_hsa033201.69969279
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.65490586
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.62243063
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.60245369
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.57639560
30One carbon pool by folate_Homo sapiens_hsa006701.56208739
31Bile secretion_Homo sapiens_hsa049761.53445070
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.50374781
33Peroxisome_Homo sapiens_hsa041461.50093367
34Phenylalanine metabolism_Homo sapiens_hsa003601.41941347
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.41914028
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.41751532
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.39948886
38Propanoate metabolism_Homo sapiens_hsa006401.36281173
39Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.35532259
40Carbon metabolism_Homo sapiens_hsa012001.29478567
41Histidine metabolism_Homo sapiens_hsa003401.28987602
42Retinol metabolism_Homo sapiens_hsa008301.27698177
43beta-Alanine metabolism_Homo sapiens_hsa004101.25250833
44Staphylococcus aureus infection_Homo sapiens_hsa051501.22519270
45Pyruvate metabolism_Homo sapiens_hsa006201.17678048
46Tyrosine metabolism_Homo sapiens_hsa003501.17471842
47Basal cell carcinoma_Homo sapiens_hsa052171.11553914
48Arginine and proline metabolism_Homo sapiens_hsa003301.10039814
49Lysine degradation_Homo sapiens_hsa003101.09233154
50Steroid biosynthesis_Homo sapiens_hsa001001.08082188
51Dilated cardiomyopathy_Homo sapiens_hsa054141.04846968
52Cyanoamino acid metabolism_Homo sapiens_hsa004601.02847108
53Fat digestion and absorption_Homo sapiens_hsa049751.02202963
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98980146
55Folate biosynthesis_Homo sapiens_hsa007900.96976394
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96745295
57Colorectal cancer_Homo sapiens_hsa052100.94593070
58Thyroid cancer_Homo sapiens_hsa052160.94103012
59Caffeine metabolism_Homo sapiens_hsa002320.93630789
60Bladder cancer_Homo sapiens_hsa052190.92617921
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92397202
62Sulfur relay system_Homo sapiens_hsa041220.90464730
63Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.89161880
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89114894
65Starch and sucrose metabolism_Homo sapiens_hsa005000.88751336
66Hippo signaling pathway_Homo sapiens_hsa043900.88411613
67Gap junction_Homo sapiens_hsa045400.83323314
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81900287
69Pathways in cancer_Homo sapiens_hsa052000.78844126
70Fatty acid elongation_Homo sapiens_hsa000620.76566417
71Rap1 signaling pathway_Homo sapiens_hsa040150.75056351
72Sulfur metabolism_Homo sapiens_hsa009200.74849405
73Prion diseases_Homo sapiens_hsa050200.74641709
74Hedgehog signaling pathway_Homo sapiens_hsa043400.72992045
75ErbB signaling pathway_Homo sapiens_hsa040120.72671721
76PI3K-Akt signaling pathway_Homo sapiens_hsa041510.72433184
77Melanoma_Homo sapiens_hsa052180.69943052
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69597069
79Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67948313
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67696276
81Cocaine addiction_Homo sapiens_hsa050300.64912733
82mRNA surveillance pathway_Homo sapiens_hsa030150.61319877
83Pentose phosphate pathway_Homo sapiens_hsa000300.60444413
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60259599
85ABC transporters_Homo sapiens_hsa020100.58785978
86Vitamin B6 metabolism_Homo sapiens_hsa007500.58676850
87Prostate cancer_Homo sapiens_hsa052150.57958365
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57218050
89Glutathione metabolism_Homo sapiens_hsa004800.55922427
90Renal cell carcinoma_Homo sapiens_hsa052110.55021554
91VEGF signaling pathway_Homo sapiens_hsa043700.52167222
92Thyroid hormone synthesis_Homo sapiens_hsa049180.50770165
93Glutamatergic synapse_Homo sapiens_hsa047240.49010922
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.48542690
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.48320576
96Fatty acid biosynthesis_Homo sapiens_hsa000610.47947200
97Cholinergic synapse_Homo sapiens_hsa047250.47933158
98Vitamin digestion and absorption_Homo sapiens_hsa049770.47147215
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46411695
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.46258496
101TGF-beta signaling pathway_Homo sapiens_hsa043500.46118539
102ECM-receptor interaction_Homo sapiens_hsa045120.45056367
103Ras signaling pathway_Homo sapiens_hsa040140.44918773
104Choline metabolism in cancer_Homo sapiens_hsa052310.44880477
105Glioma_Homo sapiens_hsa052140.44426582
106Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42795447
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42397566
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.41408667
109Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40895784
110Glycosaminoglycan degradation_Homo sapiens_hsa005310.40556615
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39759586
112MicroRNAs in cancer_Homo sapiens_hsa052060.39359093
113Adherens junction_Homo sapiens_hsa045200.39158566
114Proteoglycans in cancer_Homo sapiens_hsa052050.39098642
115Notch signaling pathway_Homo sapiens_hsa043300.37018209
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36830866
117p53 signaling pathway_Homo sapiens_hsa041150.31807387
118AMPK signaling pathway_Homo sapiens_hsa041520.31549661
119Fructose and mannose metabolism_Homo sapiens_hsa000510.30624092
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29901451
121Galactose metabolism_Homo sapiens_hsa000520.29778507
122Glycerolipid metabolism_Homo sapiens_hsa005610.27723691
123Amoebiasis_Homo sapiens_hsa051460.27590770
124Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.27493137
125Focal adhesion_Homo sapiens_hsa045100.27449572
126Metabolic pathways_Homo sapiens_hsa011000.22082143
127Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.22018201
128Insulin resistance_Homo sapiens_hsa049310.22013760
129Glucagon signaling pathway_Homo sapiens_hsa049220.21089165
130Tight junction_Homo sapiens_hsa045300.16152727
131Small cell lung cancer_Homo sapiens_hsa052220.15325384
132Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.14959285
133Melanogenesis_Homo sapiens_hsa049160.12330850
134Chronic myeloid leukemia_Homo sapiens_hsa052200.11647484
135Adipocytokine signaling pathway_Homo sapiens_hsa049200.08669465
136Endometrial cancer_Homo sapiens_hsa052130.08370437
137Insulin signaling pathway_Homo sapiens_hsa049100.07852331
138Wnt signaling pathway_Homo sapiens_hsa043100.07801931

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