IGDCC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1limb bud formation (GO:0060174)5.89648270
2presynaptic membrane assembly (GO:0097105)5.04450795
3somite development (GO:0061053)4.38579872
4presynaptic membrane organization (GO:0097090)4.26367945
5locomotory exploration behavior (GO:0035641)4.01880891
6layer formation in cerebral cortex (GO:0021819)3.81873680
7negative regulation of axon guidance (GO:1902668)3.76408905
8otic vesicle formation (GO:0030916)3.67970603
9retinal ganglion cell axon guidance (GO:0031290)3.66032344
10sodium ion export (GO:0071436)3.63009356
11negative regulation of axon extension involved in axon guidance (GO:0048843)3.60517456
12cell communication by electrical coupling (GO:0010644)3.57267108
13pyrimidine nucleobase catabolic process (GO:0006208)3.57086531
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.55281017
15negative regulation of oligodendrocyte differentiation (GO:0048715)3.52746849
16cellular potassium ion homeostasis (GO:0030007)3.50159236
17neuron projection extension involved in neuron projection guidance (GO:1902284)3.48551703
18axon extension involved in axon guidance (GO:0048846)3.48551703
19negative chemotaxis (GO:0050919)3.45579679
20regulation of short-term neuronal synaptic plasticity (GO:0048172)3.41789200
21regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.35397712
22synaptic vesicle maturation (GO:0016188)3.35198148
23vocalization behavior (GO:0071625)3.29392467
24regulation of non-canonical Wnt signaling pathway (GO:2000050)3.26965544
25planar cell polarity pathway involved in neural tube closure (GO:0090179)3.26061247
26negative regulation of astrocyte differentiation (GO:0048712)3.22425780
27exploration behavior (GO:0035640)3.21885843
28DNA double-strand break processing (GO:0000729)3.19919546
29olfactory bulb development (GO:0021772)3.17894928
30cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.17813480
31G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.15306536
32regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.15063963
33replication fork processing (GO:0031297)3.13968886
34embryonic foregut morphogenesis (GO:0048617)3.10412744
35endocardial cushion morphogenesis (GO:0003203)3.09382042
36collecting duct development (GO:0072044)3.08492931
37axonal fasciculation (GO:0007413)3.08317881
38epithelial cell fate commitment (GO:0072148)3.07867897
39dorsal/ventral axis specification (GO:0009950)3.07579505
40dendritic spine morphogenesis (GO:0060997)3.06890939
41regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.06193511
42mechanosensory behavior (GO:0007638)3.05232733
43regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.03001478
44regulation of mesoderm development (GO:2000380)3.02684161
45lens fiber cell development (GO:0070307)3.02531939
46positive regulation of synapse maturation (GO:0090129)3.02213426
47cerebral cortex radially oriented cell migration (GO:0021799)3.02006858
48lung epithelium development (GO:0060428)3.01899522
49regulation of glutamate receptor signaling pathway (GO:1900449)3.01829664
50innervation (GO:0060384)3.01828005
51positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.98907798
52synaptic vesicle docking involved in exocytosis (GO:0016081)2.96986276
53chondrocyte proliferation (GO:0035988)2.95668734
54embryonic digestive tract morphogenesis (GO:0048557)2.94964195
55regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.94905006
56cellular sodium ion homeostasis (GO:0006883)2.94587464
57regulation of axon guidance (GO:1902667)2.94325682
58glutamate secretion (GO:0014047)2.94219644
59proline transport (GO:0015824)2.93870919
60C4-dicarboxylate transport (GO:0015740)2.91209654
61establishment of nucleus localization (GO:0040023)2.88225871
62regulation of synapse structural plasticity (GO:0051823)2.88012970
63ionotropic glutamate receptor signaling pathway (GO:0035235)2.85702599
64regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.83728696
65membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.82940355
66paraxial mesoderm development (GO:0048339)2.82357906
67dendrite morphogenesis (GO:0048813)2.81670440
68gamma-aminobutyric acid transport (GO:0015812)2.81520924
69cerebellar granule cell differentiation (GO:0021707)2.81006670
70response to auditory stimulus (GO:0010996)2.79451305
71postsynaptic membrane organization (GO:0001941)2.78001012
72cornea development in camera-type eye (GO:0061303)2.77798431
73auditory behavior (GO:0031223)2.77169817
74neurotransmitter-gated ion channel clustering (GO:0072578)2.75956726
75cellular response to sterol (GO:0036315)2.75522165
76synaptic vesicle exocytosis (GO:0016079)2.74131258
77negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.74040342
78negative regulation of translation, ncRNA-mediated (GO:0040033)2.74040342
79regulation of translation, ncRNA-mediated (GO:0045974)2.74040342
80regulation of axon extension involved in axon guidance (GO:0048841)2.73846383
81neuronal stem cell maintenance (GO:0097150)2.73484263
82negative regulation of smoothened signaling pathway (GO:0045879)2.73090050
83negative regulation of DNA-dependent DNA replication (GO:2000104)2.71890939
84chromatin remodeling at centromere (GO:0031055)2.70515570
85epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.68511668
86neuron recognition (GO:0008038)2.68442308
87potassium ion import (GO:0010107)2.68048318
88negative regulation of chondrocyte differentiation (GO:0032331)2.68040752
89negative regulation of catenin import into nucleus (GO:0035414)2.66705708
90neuron cell-cell adhesion (GO:0007158)2.66488167
91response to pheromone (GO:0019236)2.66369884
92glial cell proliferation (GO:0014009)2.65411715
93spinal cord development (GO:0021510)2.65298342
94neuroblast proliferation (GO:0007405)2.65207976
95nucleobase catabolic process (GO:0046113)2.64447791
96cell migration in hindbrain (GO:0021535)2.64188374
97positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.64156928
98intraciliary transport (GO:0042073)2.63347092
99negative regulation of glial cell differentiation (GO:0045686)2.63163502
100plasma membrane repair (GO:0001778)2.62946417
101regulation of astrocyte differentiation (GO:0048710)2.62304216
102kidney morphogenesis (GO:0060993)2.62220529
103regulation of synaptic vesicle exocytosis (GO:2000300)2.62074886
104resolution of meiotic recombination intermediates (GO:0000712)2.61779196
105regulation of neuronal synaptic plasticity (GO:0048168)2.60997211
106sympathetic nervous system development (GO:0048485)2.60943917
107hindbrain development (GO:0030902)2.60487431
108protein localization to synapse (GO:0035418)2.60036856
109mesenchyme morphogenesis (GO:0072132)2.59610506
110positive regulation of potassium ion transmembrane transport (GO:1901381)2.59411125
111glutamate receptor signaling pathway (GO:0007215)2.59304209
112alanine transport (GO:0032328)2.59199263
113regulation of long-term neuronal synaptic plasticity (GO:0048169)2.58580893
114neurotransmitter secretion (GO:0007269)2.58267231
115cochlea development (GO:0090102)2.58018839
116head development (GO:0060322)2.57997987
117negative regulation of transcription regulatory region DNA binding (GO:2000678)2.57554501
118negative regulation of sodium ion transport (GO:0010766)2.56949200
119lateral sprouting from an epithelium (GO:0060601)2.56147914
120negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.55977300
121cochlea morphogenesis (GO:0090103)2.55249351
122synaptic transmission, glutamatergic (GO:0035249)2.54947723
123central nervous system projection neuron axonogenesis (GO:0021952)2.54202581
124epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.53361757
125regulation of respiratory system process (GO:0044065)2.53296216
126neuronal action potential propagation (GO:0019227)2.52474594
127negative regulation of cytosolic calcium ion concentration (GO:0051481)2.51773145
128CENP-A containing nucleosome assembly (GO:0034080)2.51415394
129axon ensheathment in central nervous system (GO:0032291)2.51415345
130central nervous system myelination (GO:0022010)2.51415345
131regulation of membrane repolarization (GO:0060306)2.51038815
132neural tube formation (GO:0001841)2.49786237
133cellular response to cholesterol (GO:0071397)2.49449367
134gonadal mesoderm development (GO:0007506)2.48321762
135heart valve formation (GO:0003188)2.47821599
136long-term memory (GO:0007616)2.47757848
137neuron fate determination (GO:0048664)2.47014958
138artery development (GO:0060840)2.46129009
139kinetochore organization (GO:0051383)2.44828271
140histone exchange (GO:0043486)2.44046939
141regulation of respiratory gaseous exchange (GO:0043576)2.43960622
142anterior/posterior axis specification, embryo (GO:0008595)2.43583387
143regulation of glycogen (starch) synthase activity (GO:2000465)2.43512251
144female gonad development (GO:0008585)2.42540944
145positive regulation of male gonad development (GO:2000020)2.41993604
146potassium ion homeostasis (GO:0055075)2.40885023
147neuromuscular junction development (GO:0007528)2.39765004
148L-amino acid import (GO:0043092)2.39707203
149embryonic pattern specification (GO:0009880)2.39617822
150outer ear morphogenesis (GO:0042473)2.39314704
151convergent extension (GO:0060026)2.38679108
152maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.37633954
153regulation of collateral sprouting (GO:0048670)2.37133245
154dermatan sulfate biosynthetic process (GO:0030208)2.37043509
155generation of neurons (GO:0048699)2.36801667
156atrial cardiac muscle cell action potential (GO:0086014)2.36466663
157cerebral cortex cell migration (GO:0021795)2.36050305
158limb development (GO:0060173)2.35705856
159appendage development (GO:0048736)2.35705856
160anterior/posterior axis specification (GO:0009948)2.35329254
161regulation of timing of cell differentiation (GO:0048505)2.35242646
162mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.35136612
163detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.34750720
164regulation of mesenchymal cell apoptotic process (GO:2001053)2.34051371
165thalamus development (GO:0021794)2.32620944
166negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.31638946
167protein-cofactor linkage (GO:0018065)2.30846450
168kinetochore assembly (GO:0051382)2.30723774
169genitalia morphogenesis (GO:0035112)2.30540284
170positive regulation of gastrulation (GO:2000543)2.27478578
171regulation of neuron migration (GO:2001222)2.26911473
172branch elongation of an epithelium (GO:0060602)2.26907384
173pancreas development (GO:0031016)2.26616986
174hindlimb morphogenesis (GO:0035137)2.24198683
175somite rostral/caudal axis specification (GO:0032525)2.23233379
176cilium morphogenesis (GO:0060271)2.22944488
177regulation of male gonad development (GO:2000018)2.22634050
178dorsal/ventral pattern formation (GO:0009953)2.22215436
179platelet dense granule organization (GO:0060155)2.21904609
180mesenchymal cell proliferation (GO:0010463)2.18915877
181positive regulation of neuroblast proliferation (GO:0002052)2.16403191
182nonmotile primary cilium assembly (GO:0035058)2.15357200
183notochord development (GO:0030903)2.15208097
184fatty acid elongation (GO:0030497)2.14620627
185regulation of nuclear cell cycle DNA replication (GO:0033262)2.14377425

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.80979045
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.28777886
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.08622484
4RNF2_18974828_ChIP-Seq_MESCs_Mouse3.02662177
5EZH2_18974828_ChIP-Seq_MESCs_Mouse3.02662177
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.90821414
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.81208104
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.80329821
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.79051636
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.77839779
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.72706703
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.72668277
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.58161521
14GBX2_23144817_ChIP-Seq_PC3_Human2.54150687
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.53258192
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.53036894
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.51222201
18* RNF2_27304074_Chip-Seq_ESCs_Mouse2.46820180
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.42114022
20FUS_26573619_Chip-Seq_HEK293_Human2.36514358
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.33811816
22EWS_26573619_Chip-Seq_HEK293_Human2.25948989
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.24675061
24VDR_22108803_ChIP-Seq_LS180_Human2.24253257
25DROSHA_22980978_ChIP-Seq_HELA_Human2.24026902
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.22090759
27TAF15_26573619_Chip-Seq_HEK293_Human2.19021045
28SUZ12_27294783_Chip-Seq_ESCs_Mouse2.16843408
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14112773
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.08793955
31* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.07615607
32PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.03202989
33IGF1R_20145208_ChIP-Seq_DFB_Human2.00944609
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.93482421
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.92226489
36AR_21572438_ChIP-Seq_LNCaP_Human1.91704146
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91258790
38WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.86620830
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.84382157
40SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.79368031
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.77584972
42EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.75839871
43RING1B_27294783_Chip-Seq_ESCs_Mouse1.73897519
44ZFP281_18757296_ChIP-ChIP_E14_Mouse1.72307370
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.71532531
46TP53_20018659_ChIP-ChIP_R1E_Mouse1.70701772
47* REST_21632747_ChIP-Seq_MESCs_Mouse1.64560527
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.62531218
49RARB_27405468_Chip-Seq_BRAIN_Mouse1.55945776
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.55823961
51MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.55327081
52IKZF1_21737484_ChIP-ChIP_HCT116_Human1.53952737
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52574719
54SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.51386890
55RING1B_27294783_Chip-Seq_NPCs_Mouse1.50278174
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.50011973
57TRIM28_21343339_ChIP-Seq_HEK293_Human1.49900924
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.49530804
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49530804
60CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.49469722
61TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.46585493
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44124074
63ER_23166858_ChIP-Seq_MCF-7_Human1.40871576
64WT1_19549856_ChIP-ChIP_CCG9911_Human1.40327585
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.39064279
66ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.36511065
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.36073379
68ZFP281_27345836_Chip-Seq_ESCs_Mouse1.35636507
69WT1_25993318_ChIP-Seq_PODOCYTE_Human1.34660435
70KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.34516540
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34172006
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32832509
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32161966
74ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.31926476
75STAT3_23295773_ChIP-Seq_U87_Human1.30302758
76EZH2_27294783_Chip-Seq_NPCs_Mouse1.29941612
77CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29540625
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29143845
79REST_18959480_ChIP-ChIP_MESCs_Mouse1.29040009
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27494508
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.26839271
82CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25544746
83ZNF274_21170338_ChIP-Seq_K562_Hela1.24406716
84TCF4_22108803_ChIP-Seq_LS180_Human1.23893633
85RUNX2_22187159_ChIP-Seq_PCA_Human1.23559359
86* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.22665410
87AR_19668381_ChIP-Seq_PC3_Human1.22473480
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22124602
89SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21800247
90STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.21565748
91KDM2B_26808549_Chip-Seq_K562_Human1.20884279
92EP300_21415370_ChIP-Seq_HL-1_Mouse1.20443697
93TBX3_20139965_ChIP-Seq_MESCs_Mouse1.19838638
94* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.19812821
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19488826
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19422134
97SMAD_19615063_ChIP-ChIP_OVARY_Human1.18664719
98CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18421968
99YAP1_20516196_ChIP-Seq_MESCs_Mouse1.17283734
100CBP_20019798_ChIP-Seq_JUKART_Human1.15864084
101IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15864084
102RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15408640
103TCF4_23295773_ChIP-Seq_U87_Human1.14594305
104TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.14286473
105RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.13228744
106SMAD4_21799915_ChIP-Seq_A2780_Human1.12933767
107PIAS1_25552417_ChIP-Seq_VCAP_Human1.12913813
108SOX2_21211035_ChIP-Seq_LN229_Gbm1.12733392
109LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12407236
110ISL1_27105846_Chip-Seq_CPCs_Mouse1.12263831
111CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12164715
112KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10987632
113CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10793489
114SOX9_26525672_Chip-Seq_HEART_Mouse1.10760002
115SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10235039
116CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09410833
117ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09109717
118SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.08944849
119NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08759352
120NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08759352
121SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.07936768
122TP53_16413492_ChIP-PET_HCT116_Human1.07476874
123SMAD4_21741376_ChIP-Seq_EPCs_Human1.07026570
124TP53_18474530_ChIP-ChIP_U2OS_Human1.06938949
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06792551
126SMAD3_21741376_ChIP-Seq_EPCs_Human1.06215288
127AR_25329375_ChIP-Seq_VCAP_Human1.06132556
128ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.05115237
129DNAJC2_21179169_ChIP-ChIP_NT2_Human1.05067446
130TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04017114
131CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03957451
132* NANOG_19829295_ChIP-Seq_ESCs_Human1.03715969
133* SOX2_19829295_ChIP-Seq_ESCs_Human1.03715969
134FLI1_21867929_ChIP-Seq_TH2_Mouse1.03580207
135P53_22387025_ChIP-Seq_ESCs_Mouse1.03027229
136EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02499736
137ARNT_22903824_ChIP-Seq_MCF-7_Human1.01450905
138ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99858432
139P300_19829295_ChIP-Seq_ESCs_Human0.98174523
140NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96119355
141AHR_22903824_ChIP-Seq_MCF-7_Human0.96036657
142BCAT_22108803_ChIP-Seq_LS180_Human0.95638337
143CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95154843
144RXR_22108803_ChIP-Seq_LS180_Human0.94473067
145HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.91352007
146OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90000040
147SMAD4_21741376_ChIP-Seq_HESCs_Human0.89909213
148TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89065214
149SMAD3_21741376_ChIP-Seq_HESCs_Human0.89019946
150BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88432283
151TP63_17297297_ChIP-ChIP_HaCaT_Human0.88012337
152SMAD3_21741376_ChIP-Seq_ESCs_Human0.87520082
153POU5F1_16153702_ChIP-ChIP_HESCs_Human0.87388572
154NR3C1_23031785_ChIP-Seq_PC12_Mouse0.87094628
155TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.86809134
156TBX3_20139965_ChIP-Seq_ESCs_Mouse0.85212263
157RNF2_27304074_Chip-Seq_NSC_Mouse0.85154441
158BMI1_23680149_ChIP-Seq_NPCS_Mouse0.85048422

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.77149205
2MP0003880_abnormal_central_pattern3.37345632
3MP0009780_abnormal_chondrocyte_physiolo3.02350986
4MP0010030_abnormal_orbit_morphology2.99896838
5MP0005423_abnormal_somatic_nervous2.71246360
6MP0006292_abnormal_olfactory_placode2.59078250
7MP0000566_synostosis2.44382089
8MP0004270_analgesia2.37866740
9MP0003890_abnormal_embryonic-extraembry2.37830568
10MP0003635_abnormal_synaptic_transmissio2.33341134
11MP0002102_abnormal_ear_morphology2.30347823
12MP0000751_myopathy2.28585939
13MP0003122_maternal_imprinting2.25666390
14MP0004858_abnormal_nervous_system2.14809556
15MP0005248_abnormal_Harderian_gland1.96291160
16MP0004145_abnormal_muscle_electrophysio1.89274970
17MP0003283_abnormal_digestive_organ1.87827828
18MP0001293_anophthalmia1.86801326
19MP0005503_abnormal_tendon_morphology1.86604460
20MP0000778_abnormal_nervous_system1.85833925
21MP0000516_abnormal_urinary_system1.84423519
22MP0005367_renal/urinary_system_phenotyp1.84423519
23MP0005623_abnormal_meninges_morphology1.81742166
24MP0000049_abnormal_middle_ear1.81410464
25MP0002089_abnormal_postnatal_growth/wei1.79866704
26MP0002751_abnormal_autonomic_nervous1.75980423
27MP0002063_abnormal_learning/memory/cond1.74031620
28MP0001299_abnormal_eye_distance/1.70879607
29MP0008438_abnormal_cutaneous_collagen1.70774558
30MP0009745_abnormal_behavioral_response1.63698829
31MP0004133_heterotaxia1.61035692
32MP0002249_abnormal_larynx_morphology1.60304216
33MP0008789_abnormal_olfactory_epithelium1.60282495
34MP0004233_abnormal_muscle_weight1.57788220
35MP0001529_abnormal_vocalization1.56896307
36MP0003136_yellow_coat_color1.56426180
37MP0003385_abnormal_body_wall1.56352637
38MP0006072_abnormal_retinal_apoptosis1.55776236
39MP0001486_abnormal_startle_reflex1.51116924
40MP0002254_reproductive_system_inflammat1.50705140
41MP0000749_muscle_degeneration1.50128726
42MP0009250_abnormal_appendicular_skeleto1.48340542
43MP0008877_abnormal_DNA_methylation1.47546038
44MP0009046_muscle_twitch1.46254338
45MP0002064_seizures1.45986125
46MP0006054_spinal_hemorrhage1.45478975
47MP0004885_abnormal_endolymph1.44723667
48MP0000428_abnormal_craniofacial_morphol1.44239698
49MP0005253_abnormal_eye_physiology1.40223540
50MP0001984_abnormal_olfaction1.39258589
51MP0002734_abnormal_mechanical_nocicepti1.38469713
52MP0000955_abnormal_spinal_cord1.37428384
53MP0004134_abnormal_chest_morphology1.37184361
54MP0002108_abnormal_muscle_morphology1.37008958
55MP0002572_abnormal_emotion/affect_behav1.35009152
56MP0008569_lethality_at_weaning1.32906899
57MP0009053_abnormal_anal_canal1.32732768
58MP0001286_abnormal_eye_development1.32342640
59MP0003938_abnormal_ear_development1.32058375
60MP0003942_abnormal_urinary_system1.30582893
61MP0002184_abnormal_innervation1.29043775
62MP0000647_abnormal_sebaceous_gland1.28919210
63MP0000534_abnormal_ureter_morphology1.26826874
64MP0001958_emphysema1.26032785
65MP0000733_abnormal_muscle_development1.25055582
66MP0003755_abnormal_palate_morphology1.22853694
67MP0002697_abnormal_eye_size1.21641115
68MP0003115_abnormal_respiratory_system1.21534713
69MP0002234_abnormal_pharynx_morphology1.20246130
70MP0003279_aneurysm1.18673076
71MP0003941_abnormal_skin_development1.18594335
72MP0004272_abnormal_basement_membrane1.18116522
73MP0005551_abnormal_eye_electrophysiolog1.14168870
74MP0003123_paternal_imprinting1.14093405
75MP0003121_genomic_imprinting1.13270958
76MP0005391_vision/eye_phenotype1.13110942
77MP0001485_abnormal_pinna_reflex1.12717811
78MP0002233_abnormal_nose_morphology1.12706236
79MP0003567_abnormal_fetal_cardiomyocyte1.12516453
80MP0001968_abnormal_touch/_nociception1.11596850
81MP0002272_abnormal_nervous_system1.09880733
82MP0002557_abnormal_social/conspecific_i1.09799019
83MP0002116_abnormal_craniofacial_bone1.07741866
84MP0002882_abnormal_neuron_morphology1.06053528
85MP0003787_abnormal_imprinting1.05812529
86MP0003137_abnormal_impulse_conducting1.03421566
87MP0002152_abnormal_brain_morphology1.03006774
88MP0000462_abnormal_digestive_system1.02998669
89MP0000432_abnormal_head_morphology1.02665699
90MP0002653_abnormal_ependyma_morphology1.02652716
91MP0002932_abnormal_joint_morphology1.01815380
92MP0003935_abnormal_craniofacial_develop1.01723516
93MP0000537_abnormal_urethra_morphology1.01612334
94MP0002067_abnormal_sensory_capabilities1.00557192
95MP0003861_abnormal_nervous_system0.99824293
96MP0001440_abnormal_grooming_behavior0.99819723
97MP0002752_abnormal_somatic_nervous0.98404920
98MP0006276_abnormal_autonomic_nervous0.98106901
99MP0001177_atelectasis0.97620094
100MP0009384_cardiac_valve_regurgitation0.97476373
101MP0008961_abnormal_basal_metabolism0.96480655
102MP0004811_abnormal_neuron_physiology0.95356271
103MP0000026_abnormal_inner_ear0.95325984
104MP0000762_abnormal_tongue_morphology0.94530923
105MP0005508_abnormal_skeleton_morphology0.94527086
106MP0002109_abnormal_limb_morphology0.93991620
107MP0005386_behavior/neurological_phenoty0.93422404
108MP0004924_abnormal_behavior0.93422404
109MP0003315_abnormal_perineum_morphology0.93191925
110MP0005369_muscle_phenotype0.92674724
111MP0005257_abnormal_intraocular_pressure0.91950946
112MP0003329_amyloid_beta_deposits0.91705383
113MP0000383_abnormal_hair_follicle0.89974046
114MP0001502_abnormal_circadian_rhythm0.89841245
115MP0002092_abnormal_eye_morphology0.89504941
116MP0008058_abnormal_DNA_repair0.87831131
117MP0005187_abnormal_penis_morphology0.87434790
118MP0003119_abnormal_digestive_system0.87073129
119MP0004215_abnormal_myocardial_fiber0.86180513
120MP0000631_abnormal_neuroendocrine_gland0.85800847
121MP0002736_abnormal_nociception_after0.85307368
122MP0010094_abnormal_chromosome_stability0.84687974
123MP0002938_white_spotting0.84030510
124MP0002106_abnormal_muscle_physiology0.83768415
125MP0000747_muscle_weakness0.83628822
126MP0002111_abnormal_tail_morphology0.83599278
127MP0004087_abnormal_muscle_fiber0.81934299
128MP0002837_dystrophic_cardiac_calcinosis0.81880463
129MP0002733_abnormal_thermal_nociception0.81834775
130MP0005195_abnormal_posterior_eye0.81540160
131MP0002282_abnormal_trachea_morphology0.80946782
132MP0003634_abnormal_glial_cell0.80868563
133MP0005275_abnormal_skin_tensile0.80732651
134MP0002066_abnormal_motor_capabilities/c0.80664463
135MP0003937_abnormal_limbs/digits/tail_de0.79729521
136MP0002735_abnormal_chemical_nociception0.79489805
137MP0001943_abnormal_respiration0.79414624
138MP0005499_abnormal_olfactory_system0.79401458
139MP0005394_taste/olfaction_phenotype0.79401458
140MP0002896_abnormal_bone_mineralization0.79210004
141MP0005171_absent_coat_pigmentation0.79187894
142MP0002084_abnormal_developmental_patter0.78980528
143MP0003195_calcinosis0.78920603
144MP0003690_abnormal_glial_cell0.78182172
145MP0002114_abnormal_axial_skeleton0.77996710

Predicted human phenotypes

RankGene SetZ-score
1Aplasia of the phalanges of the hand (HP:0009802)3.64741496
2Aplasia involving bones of the extremities (HP:0009825)3.64741496
3Aplasia involving bones of the upper limbs (HP:0009823)3.64741496
4Neonatal short-limb short stature (HP:0008921)3.48193643
5Type 1 muscle fiber predominance (HP:0003803)3.32340348
6Megalencephaly (HP:0001355)3.32038796
7Intestinal atresia (HP:0011100)3.22317869
8Shallow orbits (HP:0000586)3.14908306
9True hermaphroditism (HP:0010459)3.14144985
10Protrusio acetabuli (HP:0003179)3.02972379
11Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.99629659
12Short 4th metacarpal (HP:0010044)2.99629659
13Colon cancer (HP:0003003)2.94007958
14Broad metatarsal (HP:0001783)2.92847615
15Volvulus (HP:0002580)2.89459004
16Anophthalmia (HP:0000528)2.84261793
17Pancreatic fibrosis (HP:0100732)2.77447576
18Coronal craniosynostosis (HP:0004440)2.74066864
19Abnormality of the labia minora (HP:0012880)2.70719099
20Vitreoretinal degeneration (HP:0000655)2.69883895
21Focal motor seizures (HP:0011153)2.68651209
22Bifid tongue (HP:0010297)2.66889649
23Septo-optic dysplasia (HP:0100842)2.63878515
24Pancreatic cysts (HP:0001737)2.55796502
25Abnormality of midbrain morphology (HP:0002418)2.51131836
26Molar tooth sign on MRI (HP:0002419)2.51131836
27Renal hypoplasia (HP:0000089)2.49436080
28Follicular hyperkeratosis (HP:0007502)2.47894889
29Preaxial foot polydactyly (HP:0001841)2.45885904
30Abnormality of the ischium (HP:0003174)2.45388361
31Renal duplication (HP:0000075)2.44730089
32Optic nerve hypoplasia (HP:0000609)2.43251156
33Abnormality of the 4th metacarpal (HP:0010012)2.43021929
34Oligodactyly (hands) (HP:0001180)2.42938263
35Genital tract atresia (HP:0001827)2.38373602
36Nephronophthisis (HP:0000090)2.38111755
37Aplasia/Hypoplasia of the tibia (HP:0005772)2.33670800
38Bladder diverticulum (HP:0000015)2.33577293
39Aplasia/Hypoplasia of the tongue (HP:0010295)2.32482578
40Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.32392122
41Hyperventilation (HP:0002883)2.31136647
42Infantile muscular hypotonia (HP:0008947)2.27779428
43Abnormal lung lobation (HP:0002101)2.26176323
44Focal seizures (HP:0007359)2.24929360
45Vaginal atresia (HP:0000148)2.23210860
46Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.21998353
47Glioma (HP:0009733)2.21204591
48Gastrointestinal atresia (HP:0002589)2.18007733
49Increased variability in muscle fiber diameter (HP:0003557)2.16826626
50Muscle fiber inclusion bodies (HP:0100299)2.16197892
51Morphological abnormality of the middle ear (HP:0008609)2.15773127
52Neoplasm of the adrenal cortex (HP:0100641)2.15093561
53Deviation of the hallux (HP:0010051)2.13744863
54Premature rupture of membranes (HP:0001788)2.12089199
55Alacrima (HP:0000522)2.11574932
56Bilateral microphthalmos (HP:0007633)2.09841037
57Long clavicles (HP:0000890)2.09232252
58Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.08765475
59Abnormality of the astrocytes (HP:0100707)2.07357960
60Astrocytoma (HP:0009592)2.07357960
61Neoplasm of the heart (HP:0100544)2.07101534
62Aplasia/Hypoplasia of the sternum (HP:0006714)2.07037832
63Short tibia (HP:0005736)2.06642561
64Preaxial hand polydactyly (HP:0001177)2.06423101
65Insomnia (HP:0100785)2.06275745
66Hallux valgus (HP:0001822)2.06185021
67Mixed hearing impairment (HP:0000410)2.06130911
68Myokymia (HP:0002411)2.06077604
69Abnormality of the renal medulla (HP:0100957)2.04404833
70Mildly elevated creatine phosphokinase (HP:0008180)2.04005498
71Hyperacusis (HP:0010780)2.03590782
72Round ear (HP:0100830)2.03540206
73Progressive cerebellar ataxia (HP:0002073)2.01885355
74Abnormality of the middle phalanges of the toes (HP:0010183)1.99629150
75Flat cornea (HP:0007720)1.98460205
76Oligodactyly (HP:0012165)1.97784019
77Popliteal pterygium (HP:0009756)1.97454639
78Genetic anticipation (HP:0003743)1.97428989
79Chronic hepatic failure (HP:0100626)1.97313528
80Epileptic encephalopathy (HP:0200134)1.96991156
81Ankle contracture (HP:0006466)1.96898589
82Drooling (HP:0002307)1.96853526
83Postaxial foot polydactyly (HP:0001830)1.96757360
84Abnormality of skeletal muscle fiber size (HP:0012084)1.96649257
85Postaxial hand polydactyly (HP:0001162)1.95813481
86Hepatoblastoma (HP:0002884)1.95759642
87Abnormality of the phalanges of the 2nd finger (HP:0009541)1.95728742
88Supernumerary spleens (HP:0009799)1.95353101
89Bronchomalacia (HP:0002780)1.94278107
90Hemiplegia (HP:0002301)1.93396814
91Trigonocephaly (HP:0000243)1.93377194
92Renovascular hypertension (HP:0100817)1.93092218
93Abnormality of the calf musculature (HP:0001430)1.92831495
94Hemiparesis (HP:0001269)1.92557357
95Overriding aorta (HP:0002623)1.92405235
96Narrow nasal bridge (HP:0000446)1.92386976
97Exercise-induced myalgia (HP:0003738)1.91890278
98Absent septum pellucidum (HP:0001331)1.90955502
99Narrow forehead (HP:0000341)1.90800622
100Elfin facies (HP:0004428)1.90784976
101Keratoconus (HP:0000563)1.90220367
102Increased corneal curvature (HP:0100692)1.90220367
103Asymmetry of the thorax (HP:0001555)1.86197958
104Labial hypoplasia (HP:0000066)1.86086487
105Anencephaly (HP:0002323)1.85492507
106Hemivertebrae (HP:0002937)1.85461133
107Bowel diverticulosis (HP:0005222)1.85281430
108Dandy-Walker malformation (HP:0001305)1.85218723
109Visual hallucinations (HP:0002367)1.84278210
110Hypoplastic pelvis (HP:0008839)1.83474639
111Spinal rigidity (HP:0003306)1.81607998
112Medial flaring of the eyebrow (HP:0010747)1.81525263
113Medulloblastoma (HP:0002885)1.81266276
114Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.81094439
115Limited hip movement (HP:0008800)1.79824405
116Pointed chin (HP:0000307)1.79236461
117Abnormality of dentin (HP:0010299)1.78664035
118Sclerocornea (HP:0000647)1.78648152
119Hypoventilation (HP:0002791)1.78045448
120Action tremor (HP:0002345)1.78015224
121Cupped ear (HP:0000378)1.77901332
122Occipital encephalocele (HP:0002085)1.77412600
123Cystic liver disease (HP:0006706)1.76671034
124Microglossia (HP:0000171)1.75986928
125Scrotal hypoplasia (HP:0000046)1.74400472
126Germ cell neoplasia (HP:0100728)1.74054156
127Cutaneous syndactyly (HP:0012725)1.73254756
128Atrophic scars (HP:0001075)1.72751058
129Broad toe (HP:0001837)1.72275703
130Small hand (HP:0200055)1.71819699
131Aortic dissection (HP:0002647)1.71775675
132Slender build (HP:0001533)1.71591753
133Nemaline bodies (HP:0003798)1.71273579
134Hypoplastic female external genitalia (HP:0012815)1.71107219
135Meckel diverticulum (HP:0002245)1.70955236
136Distal arthrogryposis (HP:0005684)1.70208101
137Excessive salivation (HP:0003781)1.70152405
138Increased nuchal translucency (HP:0010880)1.69896956
139Arnold-Chiari malformation (HP:0002308)1.68559212
140Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.68341690
141Triphalangeal thumb (HP:0001199)1.68300314
142Abnormality of the ileum (HP:0001549)1.68242446
143Abnormality of the parathyroid morphology (HP:0011766)1.67848496
144Cutaneous finger syndactyly (HP:0010554)1.67774643
145Calf muscle hypertrophy (HP:0008981)1.67593554
146Overgrowth (HP:0001548)1.67457987
147Gait imbalance (HP:0002141)1.67372487
148Abnormality of the septum pellucidum (HP:0007375)1.66881449
149Aplasia/Hypoplasia of the uvula (HP:0010293)1.66733372
150Tarsal synostosis (HP:0008368)1.65819556
151Short hallux (HP:0010109)1.64876847
152Rib fusion (HP:0000902)1.64655090
153Neoplasm of the oral cavity (HP:0100649)1.64429712
154Difficulty running (HP:0009046)1.63898383
155Ectopic kidney (HP:0000086)1.63222902
156Growth hormone deficiency (HP:0000824)1.63195188
157Midline defect of the nose (HP:0004122)1.62313845
158Abnormality of the diencephalon (HP:0010662)1.62304633
159Exercise-induced muscle cramps (HP:0003710)1.62192311
160Abnormality of the pubic bones (HP:0003172)1.62037394
161Abnormality of binocular vision (HP:0011514)1.61633761
162Diplopia (HP:0000651)1.61633761
163Micropenis (HP:0000054)1.60972859
164Cerebellar dysplasia (HP:0007033)1.60913251
165Scapular winging (HP:0003691)1.59814076
166Tented upper lip vermilion (HP:0010804)1.59643881
167Turricephaly (HP:0000262)1.59205606
168Congenital primary aphakia (HP:0007707)1.58910628
169Abnormality of chromosome stability (HP:0003220)1.58164285
170Aplasia/Hypoplasia of the hallux (HP:0008362)1.57926051
171Chorioretinal coloboma (HP:0000567)1.57755418
172Increased connective tissue (HP:0009025)1.57503966
173Hyperextensible skin (HP:0000974)1.56349882
174Broad-based gait (HP:0002136)1.55959382
175Hypoplastic ischia (HP:0003175)1.55723440
176Abnormality of the nasolacrimal system (HP:0000614)1.55695631
177Abnormality of the antihelix (HP:0009738)1.55204452
178Buphthalmos (HP:0000557)1.55037544
179Decreased lacrimation (HP:0000633)1.54752371
180Broad hallux (HP:0010055)1.53727575
181Partial duplication of the phalanx of hand (HP:0009999)1.52543013
182Synostosis involving bones of the lower limbs (HP:0009138)1.52193880
183Synostosis involving bones of the feet (HP:0009140)1.52193880
184Cerebral aneurysm (HP:0004944)1.50649643
185Aqueductal stenosis (HP:0002410)1.50180375

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK33.94818383
2MARK12.79601922
3NTRK32.73543739
4ACVR1B2.72693481
5PHKG12.70981106
6PHKG22.70981106
7MKNK22.68853813
8BMPR1B2.67656450
9NTRK22.66110381
10LMTK22.63628442
11EPHA42.56683367
12FRK2.37069168
13DDR22.25695508
14WEE12.24395132
15PAK62.20822264
16NUAK12.17729668
17TRIM282.15423324
18PRKD32.10104861
19TRIB32.06030902
20MKNK11.96008101
21LATS21.85803691
22TNIK1.82916951
23MINK11.81167043
24MAP3K91.78707297
25CAMKK11.77199831
26MAP3K41.71365190
27PDGFRA1.66234616
28PLK41.65584147
29KSR11.61902533
30RIPK11.61046470
31DAPK21.58453574
32EPHB21.58317048
33BRSK21.57335972
34GRK11.54097617
35SIK11.51611135
36OBSCN1.50208455
37DMPK1.48678834
38TTN1.48654173
39TAF11.47440372
40MAP4K21.45583569
41ERBB31.43435745
42PLK31.43182782
43MAPK131.41968728
44CSNK1G11.40340253
45CSNK1G21.40210029
46CDC42BPA1.39221354
47DYRK21.37201496
48TYRO31.37119355
49FGFR11.36470565
50NTRK11.34802782
51BCR1.32146414
52TGFBR11.31658528
53FGFR21.30580879
54STK381.26004591
55FGFR31.24405402
56VRK21.23275600
57ADRBK21.19937441
58PKN21.19904300
59PAK31.19236261
60CSNK1G31.17338605
61MAP3K71.15932049
62UHMK11.14506863
63STK391.14309802
64LATS11.11467512
65SIK21.11223839
66ROCK11.10626072
67CSNK1A1L1.08235023
68PBK1.07219697
69KSR21.04213104
70ROCK21.03765347
71MAP2K41.01028366
72PLK20.98912884
73CDK50.95978038
74BRSK10.95193060
75MUSK0.95182700
76BUB10.94941642
77NEK60.94877542
78FER0.89069000
79CASK0.88679034
80PASK0.88337061
81ICK0.88227463
82PKN10.86773964
83DYRK30.86761390
84PINK10.86256406
85NEK10.85795241
86EIF2AK30.83052087
87VRK10.81286369
88CAMK1G0.79362460
89ERBB40.78560582
90PRKCG0.77465209
91CDK30.76625445
92SRPK10.76588004
93CDK150.75785449
94TSSK60.75681358
95NLK0.75170764
96CDK180.74900564
97OXSR10.73635614
98ZAK0.73569325
99TTK0.72107447
100DYRK1A0.71721282
101ERBB20.71019931
102PTK60.69876443
103ALK0.69211106
104CDK140.68461049
105MELK0.67821839
106MAP2K70.66050589
107PRKCH0.65791271
108SGK2230.63065144
109SGK4940.63065144
110CDK11A0.62738865
111PAK20.62166097
112PLK10.61959946
113RET0.59910616
114BRD40.58742962
115INSRR0.58588851
116EIF2AK20.58553461
117BMX0.57815237
118SGK10.57221796
119SGK20.57177829
120PRKCZ0.57129997
121CDK80.56544684
122SGK30.56002268
123CDC70.55933034
124STK30.55773498
125MAPK120.54819596
126CAMK2A0.54631344
127MAPK100.53445943
128MAPKAPK50.52150100
129MARK20.51879124
130STK110.51261682
131RPS6KA30.50799102
132MTOR0.50371058
133PTK2B0.49086010
134WNK10.49029844
135AKT20.49014422
136ATR0.47888390
137STK38L0.45779151
138PIK3CA0.44572969
139CHEK20.43755045
140CAMK10.43266786
141PRPF4B0.42632181
142PAK40.41671645
143ATM0.41548775
144ADRBK10.40544187
145PNCK0.39289313
146MAPK90.38900872
147PTK20.38406362
148MAPK80.38049220
149RPS6KA40.37521027
150PRKCE0.36245735
151CAMK40.36104378
152CCNB10.35978033
153AKT30.35921530
154MAP2K10.35834600
155CSNK1D0.34746045
156PRKDC0.34309719
157CAMK2D0.33198378
158CDK90.32867849
159PRKG10.32738523
160YES10.31777410
161NEK90.30851142
162CSNK1A10.30113788

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.86042169
2Nicotine addiction_Homo sapiens_hsa050332.63966930
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.60476345
4Propanoate metabolism_Homo sapiens_hsa006402.59530082
5Steroid biosynthesis_Homo sapiens_hsa001002.46047538
6Protein export_Homo sapiens_hsa030602.40772856
7Nitrogen metabolism_Homo sapiens_hsa009102.17973374
8Non-homologous end-joining_Homo sapiens_hsa034502.07535068
9Butanoate metabolism_Homo sapiens_hsa006502.06479275
10Circadian entrainment_Homo sapiens_hsa047132.05406086
11GABAergic synapse_Homo sapiens_hsa047272.03523083
12Basal cell carcinoma_Homo sapiens_hsa052172.02255197
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.96475529
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.95411630
15Fanconi anemia pathway_Homo sapiens_hsa034601.90002690
16Glutamatergic synapse_Homo sapiens_hsa047241.86367617
17Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.84507862
18Long-term potentiation_Homo sapiens_hsa047201.80320287
19Homologous recombination_Homo sapiens_hsa034401.76346485
20Hedgehog signaling pathway_Homo sapiens_hsa043401.76107905
21Gastric acid secretion_Homo sapiens_hsa049711.76101982
22Salivary secretion_Homo sapiens_hsa049701.74588048
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.73266159
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.72592060
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.72462374
26Insulin secretion_Homo sapiens_hsa049111.70419077
27Dilated cardiomyopathy_Homo sapiens_hsa054141.69497069
28Olfactory transduction_Homo sapiens_hsa047401.68562190
29Fatty acid elongation_Homo sapiens_hsa000621.67443056
30Axon guidance_Homo sapiens_hsa043601.65193931
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.63737467
32Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.63676506
33Amphetamine addiction_Homo sapiens_hsa050311.61189719
34Basal transcription factors_Homo sapiens_hsa030221.59257090
35Morphine addiction_Homo sapiens_hsa050321.57990929
36Synaptic vesicle cycle_Homo sapiens_hsa047211.55035384
37Melanogenesis_Homo sapiens_hsa049161.54778688
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.53729048
39Dorso-ventral axis formation_Homo sapiens_hsa043201.51399840
40Oxytocin signaling pathway_Homo sapiens_hsa049211.48154843
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.43575945
42Phototransduction_Homo sapiens_hsa047441.42294439
43Gap junction_Homo sapiens_hsa045401.42071272
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.41573811
45Renin secretion_Homo sapiens_hsa049241.40665110
46Cholinergic synapse_Homo sapiens_hsa047251.40105321
47Dopaminergic synapse_Homo sapiens_hsa047281.40052819
48Hippo signaling pathway_Homo sapiens_hsa043901.39234474
49Notch signaling pathway_Homo sapiens_hsa043301.37898721
50Calcium signaling pathway_Homo sapiens_hsa040201.34792049
51Long-term depression_Homo sapiens_hsa047301.30969931
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.30694723
53Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.28234166
54GnRH signaling pathway_Homo sapiens_hsa049121.27316259
55Wnt signaling pathway_Homo sapiens_hsa043101.22778848
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.22186471
57Cocaine addiction_Homo sapiens_hsa050301.20464164
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.18426803
59Pyruvate metabolism_Homo sapiens_hsa006201.18204280
60cAMP signaling pathway_Homo sapiens_hsa040241.17573290
61Glioma_Homo sapiens_hsa052141.17149961
62Mismatch repair_Homo sapiens_hsa034301.17051152
63Thyroid hormone signaling pathway_Homo sapiens_hsa049191.15654514
64ECM-receptor interaction_Homo sapiens_hsa045121.15463162
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.15293529
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.14698251
67Estrogen signaling pathway_Homo sapiens_hsa049151.14547830
68Fatty acid metabolism_Homo sapiens_hsa012121.14427000
69cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12167621
70Fatty acid biosynthesis_Homo sapiens_hsa000611.11093290
71RNA degradation_Homo sapiens_hsa030181.11049187
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06080666
73Focal adhesion_Homo sapiens_hsa045101.05578606
74Cardiac muscle contraction_Homo sapiens_hsa042601.03941117
75Taste transduction_Homo sapiens_hsa047421.03781803
76Protein digestion and absorption_Homo sapiens_hsa049741.03580227
77Pancreatic secretion_Homo sapiens_hsa049721.00439293
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.00197247
79Cell cycle_Homo sapiens_hsa041101.00168768
80Proteoglycans in cancer_Homo sapiens_hsa052050.99066272
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95504963
82Serotonergic synapse_Homo sapiens_hsa047260.95313559
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.92149943
84ErbB signaling pathway_Homo sapiens_hsa040120.91434740
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.88518705
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.85157115
87Fatty acid degradation_Homo sapiens_hsa000710.84429347
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83862084
89Type II diabetes mellitus_Homo sapiens_hsa049300.83599281
90Oocyte meiosis_Homo sapiens_hsa041140.83409498
91Bladder cancer_Homo sapiens_hsa052190.83345939
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.83006272
93beta-Alanine metabolism_Homo sapiens_hsa004100.81666348
94Rap1 signaling pathway_Homo sapiens_hsa040150.81367781
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.80640709
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80401828
97mTOR signaling pathway_Homo sapiens_hsa041500.79324203
98Endometrial cancer_Homo sapiens_hsa052130.79043294
99Lysine degradation_Homo sapiens_hsa003100.78891717
100TGF-beta signaling pathway_Homo sapiens_hsa043500.78596864
101Caffeine metabolism_Homo sapiens_hsa002320.77716023
102Bile secretion_Homo sapiens_hsa049760.77292798
103Tight junction_Homo sapiens_hsa045300.76800724
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76694731
105MAPK signaling pathway_Homo sapiens_hsa040100.76556050
106MicroRNAs in cancer_Homo sapiens_hsa052060.76117516
107Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75983120
108Tryptophan metabolism_Homo sapiens_hsa003800.75609775
109Nucleotide excision repair_Homo sapiens_hsa034200.75488105
110Thyroid hormone synthesis_Homo sapiens_hsa049180.75212227
111Proteasome_Homo sapiens_hsa030500.74068372
112Fat digestion and absorption_Homo sapiens_hsa049750.73739438
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73319848
114Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73168765
115RNA transport_Homo sapiens_hsa030130.72021154
116Retinol metabolism_Homo sapiens_hsa008300.71876481
117Glucagon signaling pathway_Homo sapiens_hsa049220.71665087
118Cysteine and methionine metabolism_Homo sapiens_hsa002700.70497215
119Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70255120
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.69756054
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69375255
122Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68374873
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.68327274
124RNA polymerase_Homo sapiens_hsa030200.68089370
125Selenocompound metabolism_Homo sapiens_hsa004500.67824833
126Adherens junction_Homo sapiens_hsa045200.65630328
127Colorectal cancer_Homo sapiens_hsa052100.65125626
128p53 signaling pathway_Homo sapiens_hsa041150.64610990
129Ovarian steroidogenesis_Homo sapiens_hsa049130.64261160
130Glutathione metabolism_Homo sapiens_hsa004800.64234238
131Insulin signaling pathway_Homo sapiens_hsa049100.63775631
132Peroxisome_Homo sapiens_hsa041460.63735205
133Choline metabolism in cancer_Homo sapiens_hsa052310.63441696
134Melanoma_Homo sapiens_hsa052180.63292537
135Chemical carcinogenesis_Homo sapiens_hsa052040.62211377
136alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60455869
137Ras signaling pathway_Homo sapiens_hsa040140.59972681
138Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59714917
139Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59556753
140Linoleic acid metabolism_Homo sapiens_hsa005910.58161336
1412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56005020
142Renal cell carcinoma_Homo sapiens_hsa052110.55827788
143Prion diseases_Homo sapiens_hsa050200.54645192
144AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54027968
145Parkinsons disease_Homo sapiens_hsa050120.53356583
146Ether lipid metabolism_Homo sapiens_hsa005650.52470561
147Vitamin B6 metabolism_Homo sapiens_hsa007500.51973203
148Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51404706
149Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51285392
150Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51280237
151Circadian rhythm_Homo sapiens_hsa047100.51039691
152Pathways in cancer_Homo sapiens_hsa052000.50886858
153mRNA surveillance pathway_Homo sapiens_hsa030150.50741742
154Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50545336
155Steroid hormone biosynthesis_Homo sapiens_hsa001400.50106031
156Non-small cell lung cancer_Homo sapiens_hsa052230.49969800
157Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49957606
158Huntingtons disease_Homo sapiens_hsa050160.49163090
159Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45292328
160Vitamin digestion and absorption_Homo sapiens_hsa049770.45109000

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