IGBP1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1opioid receptor signaling pathway (GO:0038003)5.34380239
2leukotriene biosynthetic process (GO:0019370)5.09100859
3DNA deamination (GO:0045006)4.71646272
4cysteine metabolic process (GO:0006534)4.34689246
5protein-cofactor linkage (GO:0018065)4.25972711
6dentate gyrus development (GO:0021542)4.17834564
7dopaminergic neuron differentiation (GO:0071542)4.16858102
8centriole replication (GO:0007099)4.00389170
9purine nucleotide salvage (GO:0032261)3.99367806
10nucleoside diphosphate catabolic process (GO:0009134)3.97621593
11viral mRNA export from host cell nucleus (GO:0046784)3.92857297
12DNA strand renaturation (GO:0000733)3.85480193
13GPI anchor biosynthetic process (GO:0006506)3.79709531
14DNA double-strand break processing (GO:0000729)3.74874664
15cytidine deamination (GO:0009972)3.72578601
16cytidine metabolic process (GO:0046087)3.72578601
17cytidine catabolic process (GO:0006216)3.72578601
18leukotriene metabolic process (GO:0006691)3.66267754
19cellular ketone body metabolic process (GO:0046950)3.63734131
20replication fork processing (GO:0031297)3.59415885
21GPI anchor metabolic process (GO:0006505)3.54970710
22sequestering of actin monomers (GO:0042989)3.48363055
23pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.46196216
24regulation of mesenchymal cell apoptotic process (GO:2001053)3.39690472
25negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.38926188
26dendritic spine morphogenesis (GO:0060997)3.38055365
27neural tube formation (GO:0001841)3.25489653
28replicative senescence (GO:0090399)3.24624234
29pyrimidine ribonucleoside catabolic process (GO:0046133)3.23159049
30ubiquinone metabolic process (GO:0006743)3.22401243
31somite development (GO:0061053)3.21379152
32ketone body metabolic process (GO:1902224)3.20109647
33protein complex biogenesis (GO:0070271)3.19619711
34mitochondrial respiratory chain complex I assembly (GO:0032981)3.19105465
35NADH dehydrogenase complex assembly (GO:0010257)3.19105465
36mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.19105465
37centriole assembly (GO:0098534)3.13318953
38prostate gland growth (GO:0060736)3.13291711
39purine-containing compound salvage (GO:0043101)3.11875283
40negative T cell selection (GO:0043383)3.10405444
41regulation of pigment cell differentiation (GO:0050932)3.09236665
42regulation of acyl-CoA biosynthetic process (GO:0050812)3.06208152
43phosphorelay signal transduction system (GO:0000160)3.04795972
44negative thymic T cell selection (GO:0045060)3.04738591
45L-fucose catabolic process (GO:0042355)2.99545879
46fucose catabolic process (GO:0019317)2.99545879
47L-fucose metabolic process (GO:0042354)2.99545879
48otic vesicle formation (GO:0030916)2.97170375
49epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.96491401
50pyrimidine nucleotide catabolic process (GO:0006244)2.94216979
51protein polyglutamylation (GO:0018095)2.92818077
52ribosomal small subunit assembly (GO:0000028)2.92444813
53regulation of phospholipid biosynthetic process (GO:0071071)2.91157357
54negative regulation of DNA-dependent DNA replication (GO:2000104)2.88045983
55midbrain development (GO:0030901)2.86043536
56proteasome assembly (GO:0043248)2.84974047
57DNA ligation (GO:0006266)2.84310886
58regulation of glucokinase activity (GO:0033131)2.79964369
59regulation of hexokinase activity (GO:1903299)2.79964369
60viral transcription (GO:0019083)2.78514763
61regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.77473883
62nucleotide salvage (GO:0043173)2.75295090
63urinary tract smooth muscle contraction (GO:0014848)2.74931823
64positive regulation of developmental pigmentation (GO:0048087)2.73429405
65amyloid precursor protein catabolic process (GO:0042987)2.72196402
66intestinal epithelial cell development (GO:0060576)2.69544286
67chromatin remodeling at centromere (GO:0031055)2.69408608
68base-excision repair, AP site formation (GO:0006285)2.68427191
69detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.68291682
70purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.67299528
71positive regulation of triglyceride lipase activity (GO:0061365)2.66972451
72positive regulation of lipoprotein lipase activity (GO:0051006)2.66972451
73positive thymic T cell selection (GO:0045059)2.63934076
74pyrimidine-containing compound catabolic process (GO:0072529)2.63447911
75maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.61485279
76ATP synthesis coupled proton transport (GO:0015986)2.61164392
77energy coupled proton transport, down electrochemical gradient (GO:0015985)2.61164392
78CENP-A containing nucleosome assembly (GO:0034080)2.60240101
79IMP biosynthetic process (GO:0006188)2.59858318
80icosanoid biosynthetic process (GO:0046456)2.59849930
81fatty acid derivative biosynthetic process (GO:1901570)2.59849930
82positive regulation of fatty acid beta-oxidation (GO:0032000)2.59732895
83microtubule polymerization or depolymerization (GO:0031109)2.59647022
84regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.57892747
85peristalsis (GO:0030432)2.52597035
86positive regulation of B cell differentiation (GO:0045579)2.51162058
87mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.50752033
88mitochondrial respiratory chain complex assembly (GO:0033108)2.50477608
89translational termination (GO:0006415)2.50004769
90regulation of triglyceride catabolic process (GO:0010896)2.48843406
91exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.47097047
92alkaloid metabolic process (GO:0009820)2.47042025
93positive regulation of gastrulation (GO:2000543)2.46217569
94glutathione biosynthetic process (GO:0006750)2.45555746
95limb bud formation (GO:0060174)2.44865362
96glutathione metabolic process (GO:0006749)2.44862725
97respiratory chain complex IV assembly (GO:0008535)2.44415739
98ubiquinone biosynthetic process (GO:0006744)2.44101753
99cytochrome complex assembly (GO:0017004)2.41417404
100mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.41290253

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse8.40067669
2STAT6_21828071_ChIP-Seq_BEAS2B_Human4.66468882
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.69244089
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.40296019
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.23075160
6EZH2_22144423_ChIP-Seq_EOC_Human3.21592500
7IGF1R_20145208_ChIP-Seq_DFB_Human2.82432746
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.69202684
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.57825233
10GBX2_23144817_ChIP-Seq_PC3_Human2.35623102
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.14780874
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.09564644
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04046953
14EST1_17652178_ChIP-ChIP_JURKAT_Human1.95793521
15CBX2_27304074_Chip-Seq_ESCs_Mouse1.95608325
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.83488102
17ELF1_17652178_ChIP-ChIP_JURKAT_Human1.79331582
18CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75646675
19VDR_22108803_ChIP-Seq_LS180_Human1.72807505
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72642431
21EWS_26573619_Chip-Seq_HEK293_Human1.70179515
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69461421
23RBPJ_22232070_ChIP-Seq_NCS_Mouse1.63253170
24ZNF274_21170338_ChIP-Seq_K562_Hela1.61333859
25P300_19829295_ChIP-Seq_ESCs_Human1.59064215
26MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.58758985
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.58689657
28PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.58404279
29CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.56276698
30TAF15_26573619_Chip-Seq_HEK293_Human1.55794414
31IRF8_22096565_ChIP-ChIP_GC-B_Human1.52301772
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.41679924
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41302221
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.38865260
35SALL4_22934838_ChIP-ChIP_CD34+_Human1.37086711
36RNF2_27304074_Chip-Seq_NSC_Mouse1.35147079
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33339796
38UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29562695
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26586539
40TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26586539
41VDR_23849224_ChIP-Seq_CD4+_Human1.25201726
42STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.24816549
43FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.24621511
44POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22799855
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21330757
46ELK1_19687146_ChIP-ChIP_HELA_Human1.20787170
47FOXP3_21729870_ChIP-Seq_TREG_Human1.14031650
48GATA3_26560356_Chip-Seq_TH2_Human1.13522843
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13288879
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13114673
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.12999685
52PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.12584396
53EZH2_27304074_Chip-Seq_ESCs_Mouse1.12482085
54TP63_19390658_ChIP-ChIP_HaCaT_Human1.12118469
55IRF8_21731497_ChIP-ChIP_J774_Mouse1.11586841
56GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11539322
57MYB_26560356_Chip-Seq_TH2_Human1.07842653
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.07384580
59TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05941370
60NANOG_18555785_Chip-Seq_ESCs_Mouse1.05262742
61ERG_20517297_ChIP-Seq_VCAP_Human1.05211725
62EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04446210
63ER_23166858_ChIP-Seq_MCF-7_Human1.04193204
64IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.01817870
65FUS_26573619_Chip-Seq_HEK293_Human1.01804771
66PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99735410
67SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99540634
68IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.98634876
69CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98494023
70IRF1_19129219_ChIP-ChIP_H3396_Human0.98478543
71HTT_18923047_ChIP-ChIP_STHdh_Human0.98200600
72EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97162283
73TP53_22573176_ChIP-Seq_HFKS_Human0.96572987
74P53_22387025_ChIP-Seq_ESCs_Mouse0.95888115
75RUNX2_22187159_ChIP-Seq_PCA_Human0.94575401
76RUNX_20019798_ChIP-Seq_JUKART_Human0.94450812
77KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94427560
78TCF4_22108803_ChIP-Seq_LS180_Human0.94099653
79ETS1_20019798_ChIP-Seq_JURKAT_Human0.93140403
80E2F1_18555785_Chip-Seq_ESCs_Mouse0.91985052
81P53_22127205_ChIP-Seq_FIBROBLAST_Human0.91190315
82PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90834075
83NANOG_18555785_ChIP-Seq_MESCs_Mouse0.90754322
84EGR1_23403033_ChIP-Seq_LIVER_Mouse0.89451744
85SMAD3_21741376_ChIP-Seq_EPCs_Human0.89270209
86AR_20517297_ChIP-Seq_VCAP_Human0.89070168
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88310555
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88240270
89CBP_20019798_ChIP-Seq_JUKART_Human0.88240270
90FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.88128097
91TAL1_26923725_Chip-Seq_HPCs_Mouse0.87259746
92HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.87184014
93ETV2_25802403_ChIP-Seq_MESCs_Mouse0.87031298
94EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.86226155
95LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85406536
96GATA3_21878914_ChIP-Seq_MCF-7_Human0.83601161
97CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.83545831
98STAT1_17558387_ChIP-Seq_HELA_Human0.82572036
99PIAS1_25552417_ChIP-Seq_VCAP_Human0.82245921
100SMAD4_21799915_ChIP-Seq_A2780_Human0.82033708

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ5.87244289
2MP0000566_synostosis4.74694040
3MP0003806_abnormal_nucleotide_metabolis4.04233941
4MP0000372_irregular_coat_pigmentation3.23303842
5MP0003183_abnormal_peptide_metabolism3.01869966
6MP0008995_early_reproductive_senescence2.97522231
7MP0002653_abnormal_ependyma_morphology2.75729972
8MP0002938_white_spotting2.70885698
9MP0002163_abnormal_gland_morphology2.60687880
10MP0008789_abnormal_olfactory_epithelium2.53138044
11MP0003011_delayed_dark_adaptation2.52898083
12MP0002234_abnormal_pharynx_morphology2.43722873
13MP0003136_yellow_coat_color2.38920745
14MP0005671_abnormal_response_to2.22748731
15MP0008961_abnormal_basal_metabolism2.12020783
16MP0000569_abnormal_digit_pigmentation2.08883508
17MP0004145_abnormal_muscle_electrophysio2.07718654
18MP0005394_taste/olfaction_phenotype2.05035215
19MP0005499_abnormal_olfactory_system2.05035215
20MP0003878_abnormal_ear_physiology2.03345879
21MP0005377_hearing/vestibular/ear_phenot2.03345879
22MP0005084_abnormal_gallbladder_morpholo1.97062853
23MP0003938_abnormal_ear_development1.86140215
24MP0001986_abnormal_taste_sensitivity1.79073034
25MP0002928_abnormal_bile_duct1.74133452
26MP0004381_abnormal_hair_follicle1.64951241
27MP0003252_abnormal_bile_duct1.62243495
28MP0004133_heterotaxia1.60401671
29MP0002277_abnormal_respiratory_mucosa1.57095270
30MP0003315_abnormal_perineum_morphology1.56425885
31MP0005187_abnormal_penis_morphology1.53390734
32MP0010386_abnormal_urinary_bladder1.51240608
33MP0005670_abnormal_white_adipose1.46555190
34MP0002138_abnormal_hepatobiliary_system1.45762884
35MP0004742_abnormal_vestibular_system1.44212512
36MP0009379_abnormal_foot_pigmentation1.44049557
37MP0002102_abnormal_ear_morphology1.42578815
38MP0005379_endocrine/exocrine_gland_phen1.38597898
39MP0005075_abnormal_melanosome_morpholog1.28133548
40MP0005645_abnormal_hypothalamus_physiol1.25115862
41MP0003137_abnormal_impulse_conducting1.20908645
42MP0008875_abnormal_xenobiotic_pharmacok1.18252801
43MP0002160_abnormal_reproductive_system1.11497441
44MP0003959_abnormal_lean_body1.11293230
45MP0001968_abnormal_touch/_nociception1.11108672
46MP0005551_abnormal_eye_electrophysiolog1.07618200
47MP0000049_abnormal_middle_ear1.06026929
48MP0009278_abnormal_bone_marrow1.05591197
49MP0001119_abnormal_female_reproductive1.03380518
50MP0003880_abnormal_central_pattern1.03191492
51MP0003122_maternal_imprinting0.99216788
52MP0001529_abnormal_vocalization0.97556224
53MP0003866_abnormal_defecation0.95279704
54MP0004885_abnormal_endolymph0.92724391
55MP0005423_abnormal_somatic_nervous0.92067693
56MP0005085_abnormal_gallbladder_physiolo0.90944691
57MP0003763_abnormal_thymus_physiology0.87897030
58MP0006276_abnormal_autonomic_nervous0.87657256
59MP0005389_reproductive_system_phenotype0.87546341
60MP0005266_abnormal_metabolism0.85562740
61MP0003937_abnormal_limbs/digits/tail_de0.85560116
62MP0000026_abnormal_inner_ear0.83659870
63MP0001764_abnormal_homeostasis0.81629068
64MP0006292_abnormal_olfactory_placode0.81051374
65MP0002405_respiratory_system_inflammati0.80190268
66MP0002095_abnormal_skin_pigmentation0.79673824
67MP0008872_abnormal_physiological_respon0.79170564
68MP0006072_abnormal_retinal_apoptosis0.79050112
69MP0001958_emphysema0.77971178
70MP0001485_abnormal_pinna_reflex0.76820756
71MP0003567_abnormal_fetal_cardiomyocyte0.74898183
72MP0001293_anophthalmia0.74603708
73MP0001800_abnormal_humoral_immune0.73132567
74MP0002736_abnormal_nociception_after0.72693669
75MP0002132_abnormal_respiratory_system0.70785970
76MP0003195_calcinosis0.69186428
77MP0003119_abnormal_digestive_system0.69089904
78MP0001963_abnormal_hearing_physiology0.68946315
79MP0001486_abnormal_startle_reflex0.67551320
80MP0002067_abnormal_sensory_capabilities0.67387618
81MP0002075_abnormal_coat/hair_pigmentati0.66415093
82MP0005397_hematopoietic_system_phenotyp0.66415058
83MP0001545_abnormal_hematopoietic_system0.66415058
84MP0004142_abnormal_muscle_tone0.66307323
85MP0005220_abnormal_exocrine_pancreas0.66271479
86MP0005253_abnormal_eye_physiology0.66097638
87MP0000631_abnormal_neuroendocrine_gland0.65352756
88MP0002557_abnormal_social/conspecific_i0.65330348
89MP0003646_muscle_fatigue0.64742697
90MP0002233_abnormal_nose_morphology0.63043338
91MP0001905_abnormal_dopamine_level0.62436417
92MP0000537_abnormal_urethra_morphology0.60324951
93MP0001879_abnormal_lymphatic_vessel0.58934239
94MP0000538_abnormal_urinary_bladder0.57923782
95MP0003943_abnormal_hepatobiliary_system0.57915086
96MP0000613_abnormal_salivary_gland0.56322868
97MP0009785_altered_susceptibility_to0.56298838
98MP0002638_abnormal_pupillary_reflex0.54473830
99MP0003724_increased_susceptibility_to0.54053509
100MP0002751_abnormal_autonomic_nervous0.54008377

Predicted human phenotypes

RankGene SetZ-score
1Delayed CNS myelination (HP:0002188)4.67117348
2Thyroid-stimulating hormone excess (HP:0002925)4.35301846
3Pancreatic cysts (HP:0001737)3.77620710
4True hermaphroditism (HP:0010459)3.64630978
5Oral leukoplakia (HP:0002745)3.60641071
6Esophageal atresia (HP:0002032)3.44600097
7Hypothermia (HP:0002045)3.22849145
83-Methylglutaconic aciduria (HP:0003535)3.15512173
9Renal cortical cysts (HP:0000803)3.10740011
10Hypoplasia of the capital femoral epiphysis (HP:0003090)3.05728254
11Pancreatic fibrosis (HP:0100732)3.04696823
12Respiratory difficulties (HP:0002880)2.87165666
13Absent epiphyses (HP:0010577)2.85861418
14Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.85861418
15Increased serum pyruvate (HP:0003542)2.79663544
16Bilateral microphthalmos (HP:0007633)2.77842494
17Absent phalangeal crease (HP:0006109)2.77008908
18Occipital encephalocele (HP:0002085)2.74791970
19Cystic liver disease (HP:0006706)2.64512945
20Large earlobe (HP:0009748)2.62337659
21Hepatocellular necrosis (HP:0001404)2.59788800
22Carpal bone hypoplasia (HP:0001498)2.54985632
23Abnormality of the parietal bone (HP:0002696)2.53256411
24Inability to walk (HP:0002540)2.51761042
25Gastrointestinal atresia (HP:0002589)2.49497528
26Type II lissencephaly (HP:0007260)2.45929484
27Aplasia/Hypoplasia of the tongue (HP:0010295)2.43929966
28Hepatic necrosis (HP:0002605)2.42234334
29Aplasia/Hypoplasia of the fovea (HP:0008060)2.41455959
30Hypoplasia of the fovea (HP:0007750)2.41455959
31Preaxial hand polydactyly (HP:0001177)2.31737908
32Congenital stationary night blindness (HP:0007642)2.29385102
33Severe combined immunodeficiency (HP:0004430)2.27169723
34Anencephaly (HP:0002323)2.26695214
35Unilateral renal agenesis (HP:0000122)2.24030779
36Pendular nystagmus (HP:0012043)2.22814989
37Concave nail (HP:0001598)2.22656821
38Increased corneal curvature (HP:0100692)2.22337056
39Keratoconus (HP:0000563)2.22337056
40Choroideremia (HP:0001139)2.22035965
41Rectal prolapse (HP:0002035)2.20748184
42Trigonocephaly (HP:0000243)2.20507071
43Severe global developmental delay (HP:0011344)2.20073055
44Cerebellar dysplasia (HP:0007033)2.19566935
45Vacuolated lymphocytes (HP:0001922)2.19116808
46Abnormal finger flexion creases (HP:0006143)2.17866054
47Microvesicular hepatic steatosis (HP:0001414)2.16078292
48Aplastic anemia (HP:0001915)2.12773086
49Abnormality of fatty-acid metabolism (HP:0004359)2.10904494
50Mitochondrial inheritance (HP:0001427)2.09303944
51Abnormality of the antihelix (HP:0009738)2.08984592
52Colon cancer (HP:0003003)2.01830720
53Abnormality of glycolysis (HP:0004366)2.01278702
54Lipid accumulation in hepatocytes (HP:0006561)2.00506957
55Abnormality of the fovea (HP:0000493)1.99222815
56Abnormality of the renal cortex (HP:0011035)1.96426430
57Male pseudohermaphroditism (HP:0000037)1.94999756
58Absent/shortened dynein arms (HP:0200106)1.94810994
59Dynein arm defect of respiratory motile cilia (HP:0012255)1.94810994
60Vertebral fusion (HP:0002948)1.94077549
61Short tibia (HP:0005736)1.91414335
62Vertebral arch anomaly (HP:0008438)1.90918608
63Deformed sella turcica (HP:0002681)1.90637602
64Chromsome breakage (HP:0040012)1.90546140
65Postaxial foot polydactyly (HP:0001830)1.89899215
66Sclerocornea (HP:0000647)1.87738431
67Aplasia/Hypoplasia of the tibia (HP:0005772)1.87273925
68Disproportionate short-trunk short stature (HP:0003521)1.86815962
69Abnormality of the pons (HP:0007361)1.85357048
70Calf muscle hypertrophy (HP:0008981)1.85354733
71Thyroiditis (HP:0100646)1.84449294
72Absent thumb (HP:0009777)1.82345477
73Small hand (HP:0200055)1.82204394
74Abnormality of midbrain morphology (HP:0002418)1.82012081
75Molar tooth sign on MRI (HP:0002419)1.82012081
76Muscle hypertrophy of the lower extremities (HP:0008968)1.81364354
77Chromosomal breakage induced by crosslinking agents (HP:0003221)1.80324098
78Beaking of vertebral bodies (HP:0004568)1.79967722
79Attenuation of retinal blood vessels (HP:0007843)1.79059514
80Retinal dysplasia (HP:0007973)1.77644161
81Triphalangeal thumb (HP:0001199)1.77514505
82Dicarboxylic aciduria (HP:0003215)1.75953266
83Abnormality of dicarboxylic acid metabolism (HP:0010995)1.75953266
84Hypoplasia of the pons (HP:0012110)1.75519277
85Meningocele (HP:0002435)1.75170158
86Abnormality of the preputium (HP:0100587)1.72512728
87Meningioma (HP:0002858)1.72398628
88Abnormality of chromosome stability (HP:0003220)1.72115023
89Morphological abnormality of the middle ear (HP:0008609)1.71959776
90Abnormality of T cells (HP:0002843)1.71782382
91Elevated erythrocyte sedimentation rate (HP:0003565)1.71402134
92Optic nerve coloboma (HP:0000588)1.71030877
93Narrow forehead (HP:0000341)1.69575287
94Increased CSF lactate (HP:0002490)1.69536809
95Abnormality of alanine metabolism (HP:0010916)1.67779606
96Hyperalaninemia (HP:0003348)1.67779606
97Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.67779606
98Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.67677410
99Horseshoe kidney (HP:0000085)1.64716909
100Cupped ear (HP:0000378)1.63780245

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR1B4.25682291
2CDK83.59398241
3ZAK3.12358776
4BLK2.88459781
5PNCK2.84219116
6EPHB22.75893856
7FRK2.74549246
8TESK22.67728616
9TGFBR12.60537585
10TXK2.52044849
11PIK3CG2.40816546
12PLK42.40035293
13ACVR1B2.20783331
14TSSK62.17692072
15VRK21.98441657
16MAP4K21.95252198
17MAPKAPK31.78790271
18KDR1.76854380
19LMTK21.69048201
20FGFR21.58270691
21SCYL21.57786992
22PASK1.50474874
23OBSCN1.42310022
24PLK21.41149313
25STK161.35473561
26MAP3K91.29155465
27PDK21.27062841
28GRK61.22191337
29MAPK131.21059701
30TAF11.16001413
31ERBB31.14325203
32GRK51.14091744
33SYK1.09693322
34ADRBK21.08638071
35BUB11.03099479
36NUAK11.01905322
37FES1.00305043
38VRK10.95657556
39GRK10.95117207
40DYRK20.93530798
41PHKG10.93159277
42PHKG20.93159277
43TRPM70.90648759
44BRSK20.86449448
45TNK20.85202946
46WNK30.84148391
47UHMK10.83149539
48PLK30.80670191
49NEK20.80617177
50CDK190.79402787
51BTK0.78657002
52NEK10.78407131
53TGFBR20.78165192
54ITK0.77595790
55ZAP700.76574794
56DYRK30.76435769
57SRPK10.74961730
58CDK90.72779447
59GRK70.71644408
60IRAK20.70374953
61TAOK30.70079900
62MAP4K10.68873343
63INSRR0.67016681
64TEC0.62828754
65DAPK20.61906771
66IKBKE0.59637052
67MAPK110.58242747
68KIT0.57457969
69CSK0.56947453
70MAPKAPK50.53595708
71LYN0.52828503
72MARK10.51283488
73ERBB20.49690984
74MAPK150.48549283
75MAP3K40.47761901
76PIM10.47440651
77ATR0.46482979
78PRKCE0.46458641
79KSR10.46431039
80WEE10.46099485
81SGK4940.45995872
82SGK2230.45995872
83DYRK1A0.43989395
84LCK0.43609150
85PRKG10.41114153
86MAP2K40.38415938
87IRAK40.35722667
88MAPK120.35650157
89CASK0.35341603
90PLK10.35100052
91ATM0.32950143
92TBK10.32313916
93PRKACB0.31396506
94DYRK1B0.29958588
95PAK30.29481634
96YES10.28838395
97PIK3CA0.28728399
98ADRBK10.27647957
99PRKCQ0.25504640
100PRKCG0.25078286

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002323.94765536
2Oxidative phosphorylation_Homo sapiens_hsa001903.55972520
3Ribosome_Homo sapiens_hsa030103.42711955
4Phototransduction_Homo sapiens_hsa047443.34383642
5Parkinsons disease_Homo sapiens_hsa050123.34369949
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.86747584
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.75219914
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.71774017
9Primary immunodeficiency_Homo sapiens_hsa053402.58264986
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.45891184
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.41952740
12Fanconi anemia pathway_Homo sapiens_hsa034602.18965929
13Primary bile acid biosynthesis_Homo sapiens_hsa001202.13561429
14Alzheimers disease_Homo sapiens_hsa050102.07950352
15Huntingtons disease_Homo sapiens_hsa050161.84557606
16Nitrogen metabolism_Homo sapiens_hsa009101.84098917
17Proteasome_Homo sapiens_hsa030501.82796578
18Butanoate metabolism_Homo sapiens_hsa006501.81586634
19Non-homologous end-joining_Homo sapiens_hsa034501.77446688
20Homologous recombination_Homo sapiens_hsa034401.76892111
21Hematopoietic cell lineage_Homo sapiens_hsa046401.65760810
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.62720383
23Cardiac muscle contraction_Homo sapiens_hsa042601.52291128
24RNA degradation_Homo sapiens_hsa030181.51016697
25One carbon pool by folate_Homo sapiens_hsa006701.42861994
26Antigen processing and presentation_Homo sapiens_hsa046121.39842773
27DNA replication_Homo sapiens_hsa030301.33545008
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.26627523
29Purine metabolism_Homo sapiens_hsa002301.21971674
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.21647833
31Linoleic acid metabolism_Homo sapiens_hsa005911.16993218
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14416277
33Folate biosynthesis_Homo sapiens_hsa007901.12863728
34Autoimmune thyroid disease_Homo sapiens_hsa053201.11731657
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99261302
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97112537
37Protein export_Homo sapiens_hsa030600.96433827
38TGF-beta signaling pathway_Homo sapiens_hsa043500.93628530
39Base excision repair_Homo sapiens_hsa034100.92229880
40Peroxisome_Homo sapiens_hsa041460.90315208
41Arachidonic acid metabolism_Homo sapiens_hsa005900.90226415
42Graft-versus-host disease_Homo sapiens_hsa053320.90140564
43Staphylococcus aureus infection_Homo sapiens_hsa051500.89019813
44Glutathione metabolism_Homo sapiens_hsa004800.88668229
45Chemical carcinogenesis_Homo sapiens_hsa052040.86126905
46Hedgehog signaling pathway_Homo sapiens_hsa043400.85808407
47Retinol metabolism_Homo sapiens_hsa008300.85242024
48Spliceosome_Homo sapiens_hsa030400.80105854
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79944187
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79618077
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77486907
52Basal transcription factors_Homo sapiens_hsa030220.74993470
53Allograft rejection_Homo sapiens_hsa053300.73898768
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70800222
55Selenocompound metabolism_Homo sapiens_hsa004500.69913448
56Type I diabetes mellitus_Homo sapiens_hsa049400.69165347
57Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.64154750
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63183008
59Complement and coagulation cascades_Homo sapiens_hsa046100.61642701
60beta-Alanine metabolism_Homo sapiens_hsa004100.61513160
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58387775
62Phenylalanine metabolism_Homo sapiens_hsa003600.58348053
63Mismatch repair_Homo sapiens_hsa034300.55947029
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.54680671
65Nicotine addiction_Homo sapiens_hsa050330.52155888
66Oocyte meiosis_Homo sapiens_hsa041140.51937737
67Intestinal immune network for IgA production_Homo sapiens_hsa046720.50612992
68RNA polymerase_Homo sapiens_hsa030200.50522889
69Metabolic pathways_Homo sapiens_hsa011000.46804023
70T cell receptor signaling pathway_Homo sapiens_hsa046600.45450900
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44147768
72Pyrimidine metabolism_Homo sapiens_hsa002400.43105442
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42701185
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41545539
75Ovarian steroidogenesis_Homo sapiens_hsa049130.41287963
76Tyrosine metabolism_Homo sapiens_hsa003500.40901192
77Asthma_Homo sapiens_hsa053100.37903334
78Bile secretion_Homo sapiens_hsa049760.36739015
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35273751
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33489755
81Ether lipid metabolism_Homo sapiens_hsa005650.31077798
82Notch signaling pathway_Homo sapiens_hsa043300.30273948
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28761440
84Morphine addiction_Homo sapiens_hsa050320.28036432
85Systemic lupus erythematosus_Homo sapiens_hsa053220.27716345
86Propanoate metabolism_Homo sapiens_hsa006400.27658937
87Amphetamine addiction_Homo sapiens_hsa050310.27636386
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.27589698
89Shigellosis_Homo sapiens_hsa051310.26668260
90Fat digestion and absorption_Homo sapiens_hsa049750.25856983
91Tryptophan metabolism_Homo sapiens_hsa003800.25291626
92Collecting duct acid secretion_Homo sapiens_hsa049660.24443270
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.23987007
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.23613795
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22917915
96Calcium signaling pathway_Homo sapiens_hsa040200.22811434
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.18025142
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.17891613
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.16560425
100Cell cycle_Homo sapiens_hsa041100.16361004

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