IGBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.63816618
2viral transcription (GO:0019083)6.32632935
3translational termination (GO:0006415)6.10318861
4ribosomal small subunit biogenesis (GO:0042274)5.89248993
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.26338451
6translational elongation (GO:0006414)5.20648607
7cotranslational protein targeting to membrane (GO:0006613)5.15992164
8protein targeting to ER (GO:0045047)5.15001254
9protein neddylation (GO:0045116)4.95370865
10maturation of SSU-rRNA (GO:0030490)4.93205472
11establishment of protein localization to endoplasmic reticulum (GO:0072599)4.89400200
12protein localization to endoplasmic reticulum (GO:0070972)4.83150278
13nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.70826784
14viral life cycle (GO:0019058)4.69731185
15cellular protein complex disassembly (GO:0043624)4.61619303
16translational initiation (GO:0006413)4.60723765
17ribosomal large subunit biogenesis (GO:0042273)4.44507681
18energy coupled proton transport, down electrochemical gradient (GO:0015985)4.42479500
19ATP synthesis coupled proton transport (GO:0015986)4.42479500
20establishment of protein localization to mitochondrial membrane (GO:0090151)4.10768650
21respiratory electron transport chain (GO:0022904)4.03363110
22protein complex disassembly (GO:0043241)3.97575384
23electron transport chain (GO:0022900)3.92313181
24piRNA metabolic process (GO:0034587)3.86603739
25formation of translation preinitiation complex (GO:0001731)3.86377548
26base-excision repair, AP site formation (GO:0006285)3.83860363
27mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.71488049
28macromolecular complex disassembly (GO:0032984)3.69462667
29pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.63640564
30protein targeting to mitochondrion (GO:0006626)3.61537805
31aerobic respiration (GO:0009060)3.55521205
32translation (GO:0006412)3.49509480
33protein localization to mitochondrion (GO:0070585)3.43108814
34ribonucleoprotein complex biogenesis (GO:0022613)3.42791690
35nuclear-transcribed mRNA catabolic process (GO:0000956)3.39343566
36protein targeting to membrane (GO:0006612)3.38937056
37protein maturation by protein folding (GO:0022417)3.34427801
38pyrimidine nucleotide catabolic process (GO:0006244)3.32624121
39ribonucleoprotein complex disassembly (GO:0032988)3.24728385
40mRNA catabolic process (GO:0006402)3.24093511
41establishment of protein localization to mitochondrion (GO:0072655)3.23391175
42protein complex biogenesis (GO:0070271)3.20043835
43chaperone-mediated protein transport (GO:0072321)3.19223181
44regulation of meiosis I (GO:0060631)3.18776476
45deoxyribonucleotide catabolic process (GO:0009264)3.17988261
46cullin deneddylation (GO:0010388)3.17403403
47deoxyribose phosphate catabolic process (GO:0046386)3.15613697
48regulation of mitochondrial translation (GO:0070129)3.14909139
49respiratory chain complex IV assembly (GO:0008535)3.12841994
50inner mitochondrial membrane organization (GO:0007007)3.08920594
51positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.08163650
52mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.07148079
53mitochondrial respiratory chain complex I assembly (GO:0032981)3.07148079
54NADH dehydrogenase complex assembly (GO:0010257)3.07148079
55RNA catabolic process (GO:0006401)3.04081696
56purine-containing compound salvage (GO:0043101)3.01179443
57positive regulation of ligase activity (GO:0051351)3.00818446
58organelle disassembly (GO:1903008)2.97633581
59negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.96531025
60mitochondrial respiratory chain complex assembly (GO:0033108)2.91163001
61DNA strand elongation involved in DNA replication (GO:0006271)2.87723654
62cytochrome complex assembly (GO:0017004)2.85201943
63pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.83340590
64rRNA modification (GO:0000154)2.82994502
65DNA methylation involved in gamete generation (GO:0043046)2.79848118
66mitochondrial transport (GO:0006839)2.78981922
67interferon-gamma secretion (GO:0072643)2.76210058
68DNA strand elongation (GO:0022616)2.72767413
69xenobiotic catabolic process (GO:0042178)2.72256847
70telomere maintenance via semi-conservative replication (GO:0032201)2.72007056
71tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.69782117
72RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.69782117
73protein deneddylation (GO:0000338)2.69100236
74cellular respiration (GO:0045333)2.68414150
75aldehyde catabolic process (GO:0046185)2.68044782
76folic acid-containing compound biosynthetic process (GO:0009396)2.67081182
77viral protein processing (GO:0019082)2.66836300
78rRNA processing (GO:0006364)2.61929492
79DNA unwinding involved in DNA replication (GO:0006268)2.61732173
80regulation of activation of Janus kinase activity (GO:0010533)2.58158640
81DNA deamination (GO:0045006)2.54237637
82cellular component biogenesis (GO:0044085)2.53390237
83rRNA metabolic process (GO:0016072)2.49423315
84telomere maintenance via recombination (GO:0000722)2.47736008
85deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.46485254
86mitotic recombination (GO:0006312)2.40759750
87regulation of immune response to tumor cell (GO:0002837)2.39062172
88regulation of response to tumor cell (GO:0002834)2.39062172
89positive regulation of response to tumor cell (GO:0002836)2.39062172
90positive regulation of immune response to tumor cell (GO:0002839)2.39062172
91antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.37857391
92antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.34557277
93CENP-A containing nucleosome assembly (GO:0034080)2.33253599
94nucleobase biosynthetic process (GO:0046112)2.32842662
95antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.32779065
96purine nucleobase biosynthetic process (GO:0009113)2.32550250
97response to interferon-beta (GO:0035456)2.30668510
98antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.30622234
99antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.30622234
100folic acid metabolic process (GO:0046655)2.30035224
101nucleoside salvage (GO:0043174)2.29971610
102DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.28791853
103regulation of RIG-I signaling pathway (GO:0039535)2.27975741
104ribosome assembly (GO:0042255)2.26859012
105intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.24240104
106signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.24240104
107negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.23861078
108antigen processing and presentation of endogenous antigen (GO:0019883)2.23563944
109pteridine-containing compound biosynthetic process (GO:0042559)2.22320826
110glycine metabolic process (GO:0006544)2.21931201
111DNA replication initiation (GO:0006270)2.20815290
112regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.19904294
113DNA replication checkpoint (GO:0000076)2.19404463
114telomere maintenance via telomere lengthening (GO:0010833)2.19362794
115signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.19188925
116signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.19188925
117signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.19188925
118ncRNA 3-end processing (GO:0043628)2.18545368
119primary alcohol catabolic process (GO:0034310)2.17691514
120oxidative phosphorylation (GO:0006119)2.17433813
121establishment of protein localization to membrane (GO:0090150)2.16366501
122chromatin remodeling at centromere (GO:0031055)2.15337628
123signal transduction involved in DNA integrity checkpoint (GO:0072401)2.14285884
124signal transduction involved in DNA damage checkpoint (GO:0072422)2.14285884
125natural killer cell mediated cytotoxicity (GO:0042267)2.13929513
126natural killer cell mediated immunity (GO:0002228)2.13929513
127ribosome biogenesis (GO:0042254)2.13781771
128mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.12887483
129cellular response to interferon-beta (GO:0035458)2.11349642
130signal transduction involved in cell cycle checkpoint (GO:0072395)2.10510461
131DNA damage response, detection of DNA damage (GO:0042769)2.07961396
132establishment of protein localization to organelle (GO:0072594)2.07062075
133positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.06952319
134termination of RNA polymerase III transcription (GO:0006386)2.05416130
135transcription elongation from RNA polymerase III promoter (GO:0006385)2.05416130
136regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.04910007
137tetrahydrofolate metabolic process (GO:0046653)2.03476256
138protein targeting (GO:0006605)2.03071934
139positive regulation of interferon-alpha production (GO:0032727)2.03035921
140proteasome assembly (GO:0043248)2.02347889
141pseudouridine synthesis (GO:0001522)2.01369053
142negative regulation of ligase activity (GO:0051352)2.00423329
143negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.00423329
144serine family amino acid biosynthetic process (GO:0009070)1.99988811
145nucleotide-excision repair, DNA gap filling (GO:0006297)1.99549043
146regulation of cellular amino acid metabolic process (GO:0006521)1.99081732
147anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:01.97982608

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.19229383
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.59173491
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.22616439
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.93899548
5* EST1_17652178_ChIP-ChIP_JURKAT_Human2.85939474
6* GABP_17652178_ChIP-ChIP_JURKAT_Human2.77229726
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.68942461
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.48819105
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.46770103
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.42535026
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.41001803
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.32487659
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.28345846
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.28180812
15* ELF1_17652178_ChIP-ChIP_JURKAT_Human2.21706733
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.20290817
17* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.17873246
18* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.15968570
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.15255516
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.10578421
21TP63_17297297_ChIP-ChIP_HaCaT_Human2.04517282
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.01630827
23VDR_23849224_ChIP-Seq_CD4+_Human1.99072507
24ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.98890493
25XRN2_22483619_ChIP-Seq_HELA_Human1.97717547
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.86210513
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.84653828
28NELFA_20434984_ChIP-Seq_ESCs_Mouse1.84434662
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.83667490
30DCP1A_22483619_ChIP-Seq_HELA_Human1.79651854
31FOXM1_23109430_ChIP-Seq_U2OS_Human1.79103637
32YY1_21170310_ChIP-Seq_MESCs_Mouse1.78737281
33IRF8_21731497_ChIP-ChIP_J774_Mouse1.72763951
34* ELK1_19687146_ChIP-ChIP_HELA_Human1.71675439
35CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.71317114
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.68041802
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.67055068
38FOXP3_21729870_ChIP-Seq_TREG_Human1.65834928
39PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.63960980
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.61919446
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.60804511
42* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.59142370
43AR_21909140_ChIP-Seq_LNCAP_Human1.55565897
44ERG_20887958_ChIP-Seq_HPC-7_Mouse1.53264412
45TTF2_22483619_ChIP-Seq_HELA_Human1.51421894
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.47457962
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.47247830
48PADI4_21655091_ChIP-ChIP_MCF-7_Human1.45055975
49MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.43456182
50TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.41920733
51STAT4_19710469_ChIP-ChIP_TH1__Mouse1.39840226
52SPI1_23547873_ChIP-Seq_NB4_Human1.39255965
53IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.38557845
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.38074246
55* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.36786571
56STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.35777887
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35270653
58* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33566333
59PPARA_22158963_ChIP-Seq_LIVER_Mouse1.33445944
60MYB_21317192_ChIP-Seq_ERMYB_Mouse1.32425050
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.31766156
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31127743
63GABP_19822575_ChIP-Seq_HepG2_Human1.31098564
64BP1_19119308_ChIP-ChIP_Hs578T_Human1.28172641
65CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27369820
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25397131
67NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25391991
68TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.25380631
69MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.23776049
70CIITA_25753668_ChIP-Seq_RAJI_Human1.23377280
71MYC_22102868_ChIP-Seq_BL_Human1.22482934
72ZFX_18555785_ChIP-Seq_MESCs_Mouse1.22031388
73STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21668314
74PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21492437
75CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.20773354
76POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19976837
77RXR_22158963_ChIP-Seq_LIVER_Mouse1.19958831
78RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15542982
79E2F1_21310950_ChIP-Seq_MCF-7_Human1.14667409
80ELK1_22589737_ChIP-Seq_MCF10A_Human1.14467074
81CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11370633
82ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.10771152
83* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10113222
84SALL4_22934838_ChIP-ChIP_CD34+_Human1.08991694
85VDR_21846776_ChIP-Seq_THP-1_Human1.08333894
86STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05450624
87MYCN_18555785_ChIP-Seq_MESCs_Mouse1.05345372
88* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.05291770
89* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03345806
90POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03289568
91FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.03208306
92THAP11_20581084_ChIP-Seq_MESCs_Mouse1.03077445
93POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02618504
94KDM5A_27292631_Chip-Seq_BREAST_Human1.01808163
95ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01382747
96TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00624609
97TCF3_18692474_ChIP-Seq_MEFs_Mouse0.99157041
98TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98098820
99PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97263252
100ELF5_23300383_ChIP-Seq_T47D_Human0.97110030
101NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97101455
102MYB_26560356_Chip-Seq_TH2_Human0.96684588
103TFEB_21752829_ChIP-Seq_HELA_Human0.94649679
104* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94151060
105MYC_18940864_ChIP-ChIP_HL60_Human0.93657781
106IRF1_19129219_ChIP-ChIP_H3396_Human0.93575822
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92899552
108GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92419383
109KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92173489
110* IRF8_27001747_Chip-Seq_BMDM_Mouse0.92165819
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90109683
112KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.89870117
113MAF_26560356_Chip-Seq_TH1_Human0.89684945
114MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.89250297
115CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.88716250
116OCT4_18692474_ChIP-Seq_MEFs_Mouse0.88272228
117RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88169138
118PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.87354544
119HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.86310643
120LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.86273775
121VDR_22108803_ChIP-Seq_LS180_Human0.83422619
122MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.76221535
123PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.73671960
124YY1_22570637_ChIP-Seq_MALME-3M_Human0.72697218
125CTCF_18555785_ChIP-Seq_MESCs_Mouse0.72538691
126ERG_20517297_ChIP-Seq_VCAP_Human0.67432973
127LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.66068114
128* AR_20517297_ChIP-Seq_VCAP_Human0.64907728
129FUS_26573619_Chip-Seq_HEK293_Human0.62985483
130GATA1_22383799_ChIP-Seq_G1ME_Mouse0.62133310

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level3.62590222
2MP0000372_irregular_coat_pigmentation3.33904732
3MP0005084_abnormal_gallbladder_morpholo2.77494370
4MP0003123_paternal_imprinting2.60910678
5MP0003693_abnormal_embryo_hatching2.54949686
6MP0003806_abnormal_nucleotide_metabolis2.54096795
7MP0006035_abnormal_mitochondrial_morpho2.46387975
8MP0001835_abnormal_antigen_presentation2.45328732
9MP0005464_abnormal_platelet_physiology2.44530719
10MP0009785_altered_susceptibility_to2.43111758
11MP0004957_abnormal_blastocyst_morpholog2.36470418
12MP0002102_abnormal_ear_morphology2.33849363
13MP0002396_abnormal_hematopoietic_system2.32322132
14MP0000685_abnormal_immune_system2.22631445
15MP0002163_abnormal_gland_morphology2.05864682
16MP0009379_abnormal_foot_pigmentation2.03726810
17MP0003186_abnormal_redox_activity2.01629154
18MP0002837_dystrophic_cardiac_calcinosis2.00237986
19MP0005360_urolithiasis1.95369243
20MP0010094_abnormal_chromosome_stability1.94069554
21MP0003787_abnormal_imprinting1.83966108
22MP0003077_abnormal_cell_cycle1.75603886
23MP0002148_abnormal_hypersensitivity_rea1.75151574
24MP0005025_abnormal_response_to1.72469929
25MP0005085_abnormal_gallbladder_physiolo1.71562912
26MP0003183_abnormal_peptide_metabolism1.70534840
27MP0003786_premature_aging1.68642452
28MP0002139_abnormal_hepatobiliary_system1.65634894
29MP0002277_abnormal_respiratory_mucosa1.60459712
30MP0005671_abnormal_response_to1.58096545
31MP0001800_abnormal_humoral_immune1.56736113
32MP0000490_abnormal_crypts_of1.55827926
33MP0009333_abnormal_splenocyte_physiolog1.55745710
34MP0001853_heart_inflammation1.54201049
35MP0008007_abnormal_cellular_replicative1.52839716
36MP0002254_reproductive_system_inflammat1.51100798
37MP0002006_tumorigenesis1.49842572
38MP0004142_abnormal_muscle_tone1.48118076
39MP0005387_immune_system_phenotype1.47189192
40MP0001790_abnormal_immune_system1.47189192
41MP0002166_altered_tumor_susceptibility1.46673331
42MP0002452_abnormal_antigen_presenting1.46244747
43MP0010155_abnormal_intestine_physiology1.46068173
44MP0004145_abnormal_muscle_electrophysio1.45383716
45MP0002132_abnormal_respiratory_system1.43831676
46MP0003121_genomic_imprinting1.41752606
47MP0003436_decreased_susceptibility_to1.41450671
48MP0002723_abnormal_immune_serum1.39391508
49MP0000015_abnormal_ear_pigmentation1.38600863
50MP0005000_abnormal_immune_tolerance1.38417232
51MP0001986_abnormal_taste_sensitivity1.36665440
52MP0008057_abnormal_DNA_replication1.34943387
53MP0010352_gastrointestinal_tract_polyps1.34601432
54MP0003111_abnormal_nucleus_morphology1.34398312
55MP0005174_abnormal_tail_pigmentation1.33353158
56MP0010386_abnormal_urinary_bladder1.32114383
57MP0001819_abnormal_immune_cell1.31977979
58MP0002420_abnormal_adaptive_immunity1.31830993
59MP0000749_muscle_degeneration1.31381774
60MP0000358_abnormal_cell_content/1.30519793
61* MP0002398_abnormal_bone_marrow1.27568762
62MP0002138_abnormal_hepatobiliary_system1.26645740
63MP0002419_abnormal_innate_immunity1.25516252
64MP0000858_altered_metastatic_potential1.24942504
65MP0002095_abnormal_skin_pigmentation1.24264897
66MP0005365_abnormal_bile_salt1.23128971
67MP0006082_CNS_inflammation1.21878830
68MP0008995_early_reproductive_senescence1.21146429
69MP0000689_abnormal_spleen_morphology1.20621487
70* MP0000716_abnormal_immune_system1.19483300
71MP0008789_abnormal_olfactory_epithelium1.18634175
72MP0002722_abnormal_immune_system1.18266257
73MP0003763_abnormal_thymus_physiology1.17928969
74MP0008058_abnormal_DNA_repair1.17555418
75MP0010234_abnormal_vibrissa_follicle1.17419650
76MP0005083_abnormal_biliary_tract1.17065035
77MP0008872_abnormal_physiological_respon1.16750602
78MP0008260_abnormal_autophagy1.15910830
79MP0003646_muscle_fatigue1.15865509
80MP0003724_increased_susceptibility_to1.14060329
81* MP0002429_abnormal_blood_cell1.13148887
82MP0005451_abnormal_body_composition1.12968297
83MP0005075_abnormal_melanosome_morpholog1.12798860
84MP0008469_abnormal_protein_level1.11654558
85MP0009840_abnormal_foam_cell1.10926283
86MP0000516_abnormal_urinary_system1.10687524
87MP0005367_renal/urinary_system_phenotyp1.10687524
88MP0004947_skin_inflammation1.10553998
89MP0002019_abnormal_tumor_incidence1.09556881
90MP0008932_abnormal_embryonic_tissue1.09528949
91MP0005397_hematopoietic_system_phenotyp1.09063944
92MP0001545_abnormal_hematopoietic_system1.09063944
93MP0001845_abnormal_inflammatory_respons1.08831896
94MP0003191_abnormal_cellular_cholesterol1.07571617
95MP0003718_maternal_effect1.06507745
96MP0002405_respiratory_system_inflammati1.05878583
97MP0003656_abnormal_erythrocyte_physiolo1.05555668
98MP0003567_abnormal_fetal_cardiomyocyte1.03442764
99MP0006054_spinal_hemorrhage1.03109643
100MP0008875_abnormal_xenobiotic_pharmacok1.00743888
101MP0005636_abnormal_mineral_homeostasis0.99655182
102MP0009053_abnormal_anal_canal0.98677271
103MP0004782_abnormal_surfactant_physiolog0.97024531
104MP0000343_altered_response_to0.96792310
105MP0001666_abnormal_nutrient_absorption0.96522113
106MP0009763_increased_sensitivity_to0.94953565
107MP0003448_altered_tumor_morphology0.93634261
108MP0001730_embryonic_growth_arrest0.93299248
109MP0000350_abnormal_cell_proliferation0.92981777
110MP0009764_decreased_sensitivity_to0.92098819
111MP0000383_abnormal_hair_follicle0.91726996
112MP0005408_hypopigmentation0.91574179
113MP0005379_endocrine/exocrine_gland_phen0.90434918
114MP0008877_abnormal_DNA_methylation0.90032467
115MP0003122_maternal_imprinting0.89562047
116MP0005332_abnormal_amino_acid0.89466101
117MP0003011_delayed_dark_adaptation0.89156175
118MP0001529_abnormal_vocalization0.87515994
119MP0003315_abnormal_perineum_morphology0.87435016
120MP0001764_abnormal_homeostasis0.87365735
121MP0002210_abnormal_sex_determination0.87092747
122MP0005319_abnormal_enzyme/_coenzyme0.86549634
123MP0006036_abnormal_mitochondrial_physio0.86325316
124MP0003453_abnormal_keratinocyte_physiol0.86160909
125MP0001324_abnormal_eye_pigmentation0.85827585
126MP0009643_abnormal_urine_homeostasis0.85740465
127MP0005023_abnormal_wound_healing0.85677357
128MP0004264_abnormal_extraembryonic_tissu0.85015768
129MP0000598_abnormal_liver_morphology0.83094576
130MP0000681_abnormal_thyroid_gland0.82504858
131MP0008004_abnormal_stomach_pH0.82121132
132MP0000609_abnormal_liver_physiology0.82043788
133MP0001929_abnormal_gametogenesis0.81564081
134MP0004019_abnormal_vitamin_homeostasis0.80546730
135MP0002796_impaired_skin_barrier0.80173538
136MP0003866_abnormal_defecation0.79830702
137MP0002693_abnormal_pancreas_physiology0.78954226
138MP0002928_abnormal_bile_duct0.78782275
139MP0005584_abnormal_enzyme/coenzyme_acti0.78743217
140MP0010307_abnormal_tumor_latency0.78572574
141MP0002160_abnormal_reproductive_system0.77503913
142MP0003252_abnormal_bile_duct0.77006894
143MP0009697_abnormal_copulation0.76948074
144MP0004808_abnormal_hematopoietic_stem0.76255837
145* MP0000703_abnormal_thymus_morphology0.75525290
146MP0001293_anophthalmia0.74862515
147MP0001873_stomach_inflammation0.74685836
148MP0002876_abnormal_thyroid_physiology0.74160139
149MP0001663_abnormal_digestive_system0.73859097
150MP0001145_abnormal_male_reproductive0.72083987
151MP0001756_abnormal_urination0.71931901
152MP0002653_abnormal_ependyma_morphology0.71762811
153MP0005266_abnormal_metabolism0.69362033

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.40276402
2Reticulocytopenia (HP:0001896)5.19956759
3Abnormal number of erythroid precursors (HP:0012131)4.93614583
4Macrocytic anemia (HP:0001972)4.06562284
5Abnormal mitochondria in muscle tissue (HP:0008316)3.78807358
6Pallor (HP:0000980)3.49584228
7Progressive macrocephaly (HP:0004481)3.40643875
8Abnormal hemoglobin (HP:0011902)3.39197028
9Increased intramyocellular lipid droplets (HP:0012240)3.37514421
10Renal Fanconi syndrome (HP:0001994)3.35829487
11Multiple enchondromatosis (HP:0005701)3.35616840
12Thrombocytosis (HP:0001894)3.24850837
13Respiratory difficulties (HP:0002880)3.20547381
14Elevated erythrocyte sedimentation rate (HP:0003565)2.97705976
15Increased muscle lipid content (HP:0009058)2.93143794
16Lactic acidosis (HP:0003128)2.90899124
17Nemaline bodies (HP:0003798)2.90216135
18Aplastic anemia (HP:0001915)2.83025809
19Rhabdomyolysis (HP:0003201)2.63051350
20Muscle fiber inclusion bodies (HP:0100299)2.62278325
21Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.57559010
22Oral leukoplakia (HP:0002745)2.57325916
23Abnormality of renal resorption (HP:0011038)2.47117662
24Exercise intolerance (HP:0003546)2.40909315
25Respiratory failure (HP:0002878)2.40662470
26Papillary thyroid carcinoma (HP:0002895)2.34457386
27Hypobetalipoproteinemia (HP:0003563)2.31921150
28Delayed CNS myelination (HP:0002188)2.31707294
29Hepatic necrosis (HP:0002605)2.28625927
30Degeneration of anterior horn cells (HP:0002398)2.28502949
31Abnormality of the anterior horn cell (HP:0006802)2.28502949
32Abnormality of monocarboxylic acid metabolism (HP:0010996)2.28299096
33Intrahepatic cholestasis (HP:0001406)2.27232628
34IgM deficiency (HP:0002850)2.25682848
35Pustule (HP:0200039)2.25488974
36Methylmalonic aciduria (HP:0012120)2.24110224
37Abnormality of small intestinal villus morphology (HP:0011472)2.23737569
38Villous atrophy (HP:0011473)2.23737569
39Abnormality of fatty-acid metabolism (HP:0004359)2.21078333
40Chronic otitis media (HP:0000389)2.20927312
41Petechiae (HP:0000967)2.19769621
42Abnormality of reticulocytes (HP:0004312)2.19419398
43Abnormal delayed hypersensitivity skin test (HP:0002963)2.19025046
44Rimmed vacuoles (HP:0003805)2.19017422
45Generalized aminoaciduria (HP:0002909)2.17436127
46Aplasia/Hypoplasia of the sacrum (HP:0008517)2.17329901
47Absent rod-and cone-mediated responses on ERG (HP:0007688)2.17188572
48Colon cancer (HP:0003003)2.16958778
49Lipid accumulation in hepatocytes (HP:0006561)2.16356174
50Nausea (HP:0002018)2.15302281
51Autoimmune thrombocytopenia (HP:0001973)2.14351121
52Abnormal hair whorl (HP:0010721)2.13693742
53Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.12798010
54Abnormality of pyrimidine metabolism (HP:0004353)2.12163864
55Increased serum pyruvate (HP:0003542)2.10157498
56Abnormality of glycolysis (HP:0004366)2.10157498
57Atrophy/Degeneration involving motor neurons (HP:0007373)2.09157808
58Recurrent bacterial skin infections (HP:0005406)2.09057982
59Congenital, generalized hypertrichosis (HP:0004540)2.08812036
60Increased hepatocellular lipid droplets (HP:0006565)2.07274743
61Myoglobinuria (HP:0002913)2.06625164
62Abnormal cartilage morphology (HP:0002763)2.06054322
63CNS demyelination (HP:0007305)2.04682063
64Recurrent abscess formation (HP:0002722)2.02516096
65Methylmalonic acidemia (HP:0002912)2.02007922
66Optic disc pallor (HP:0000543)2.00935215
67Palpitations (HP:0001962)1.99704400
68Spastic paraparesis (HP:0002313)1.99224280
69Hyperammonemia (HP:0001987)1.98696560
70X-linked dominant inheritance (HP:0001423)1.96687146
71Myositis (HP:0100614)1.96428211
72Recurrent viral infections (HP:0004429)1.95965027
73Abnormality of aromatic amino acid family metabolism (HP:0004338)1.95504619
74Birth length less than 3rd percentile (HP:0003561)1.94454962
75Trismus (HP:0000211)1.93744111
76Dicarboxylic aciduria (HP:0003215)1.93668025
77Abnormality of dicarboxylic acid metabolism (HP:0010995)1.93668025
783-Methylglutaconic aciduria (HP:0003535)1.93357884
79Abnormality of methionine metabolism (HP:0010901)1.93303423
80Hypoglycemic coma (HP:0001325)1.93266498
81Hepatocellular necrosis (HP:0001404)1.92936501
82Amaurosis fugax (HP:0100576)1.92556611
83Hyperphosphaturia (HP:0003109)1.91738551
84Posterior subcapsular cataract (HP:0007787)1.91601149
85Granulocytopenia (HP:0001913)1.91555528
86Distal arthrogryposis (HP:0005684)1.91354137
87Abnormality of aspartate family amino acid metabolism (HP:0010899)1.91271922
88Gastrointestinal infarctions (HP:0005244)1.91005870
89Sparse eyelashes (HP:0000653)1.90771595
90Eosinophilia (HP:0001880)1.88757722
91Combined immunodeficiency (HP:0005387)1.88164192
92Stenosis of the external auditory canal (HP:0000402)1.88084288
93Microvesicular hepatic steatosis (HP:0001414)1.87641824
94Breast hypoplasia (HP:0003187)1.86343617
95Decreased activity of mitochondrial respiratory chain (HP:0008972)1.86114243
96Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.86114243
97Emotional lability (HP:0000712)1.86095910
98IgG deficiency (HP:0004315)1.85578852
99Hyperglycinemia (HP:0002154)1.85538391
100Poor head control (HP:0002421)1.85311988
101Cerebral edema (HP:0002181)1.85304274
102Rough bone trabeculation (HP:0100670)1.84199610
103Recurrent fungal infections (HP:0002841)1.83725413
104Thyroid carcinoma (HP:0002890)1.82686209
105Reduced antithrombin III activity (HP:0001976)1.82217250
106Abnormality of the vitamin B12 metabolism (HP:0004341)1.81494058
107Eczematoid dermatitis (HP:0000976)1.80980655
108Increased serum lactate (HP:0002151)1.80746694
109Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.80544677
110Prolonged neonatal jaundice (HP:0006579)1.80384746
111Increased CSF lactate (HP:0002490)1.80220377
112Purpura (HP:0000979)1.79128356
113IgA deficiency (HP:0002720)1.79093661
114Cleft eyelid (HP:0000625)1.78834335
115Abnormality of macrophages (HP:0004311)1.78696835
116Tubulointerstitial nephritis (HP:0001970)1.78270403
117Autoimmune hemolytic anemia (HP:0001890)1.77923020
118Lethargy (HP:0001254)1.77754882
119Basal ganglia calcification (HP:0002135)1.76956623
120Exertional dyspnea (HP:0002875)1.76777680
121Constricted visual fields (HP:0001133)1.75946081
122Acute encephalopathy (HP:0006846)1.75677845
123Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.75451310
124Hyperglycinuria (HP:0003108)1.75258338
125Spastic diplegia (HP:0001264)1.74358558
126Cerebral hypomyelination (HP:0006808)1.74290955
127Metaphyseal dysplasia (HP:0100255)1.73150021
128Mitochondrial inheritance (HP:0001427)1.72629386
129Neoplasm of the adrenal gland (HP:0100631)1.71873819
130Increased serum ferritin (HP:0003281)1.71074734
131Acute necrotizing encephalopathy (HP:0006965)1.70860392
132Microretrognathia (HP:0000308)1.70606393
133Testicular atrophy (HP:0000029)1.70272690
134Abnormality of glycine metabolism (HP:0010895)1.69849210
135Abnormality of serine family amino acid metabolism (HP:0010894)1.69849210
136Increased IgM level (HP:0003496)1.68337446
137Cerebral palsy (HP:0100021)1.68234727
138Type 2 muscle fiber atrophy (HP:0003554)1.68175735
139Degeneration of the lateral corticospinal tracts (HP:0002314)1.67449009
140Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.67449009
141Type I transferrin isoform profile (HP:0003642)1.67383016
142Aplasia/Hypoplasia of the thymus (HP:0010515)1.66790425
143Skin ulcer (HP:0200042)1.66589582
144Delusions (HP:0000746)1.66528906
145Hypoplasia of the thymus (HP:0000778)1.66108314
146Panhypogammaglobulinemia (HP:0003139)1.65957457
147Recurrent skin infections (HP:0001581)1.65815625
148Pancytopenia (HP:0001876)1.65067275
149Lymphoma (HP:0002665)1.64539781
150Gangrene (HP:0100758)1.63950709
151Prolonged bleeding time (HP:0003010)1.63939376
152Cheilitis (HP:0100825)1.63787178
153Abnormality of urine glucose concentration (HP:0011016)1.63649522
154Glycosuria (HP:0003076)1.63649522
155Urticaria (HP:0001025)1.63187176
156Osteolytic defects of the phalanges of the hand (HP:0009771)1.63022198
157Osteolytic defects of the hand bones (HP:0009699)1.63022198
158Abnormality of serum amino acid levels (HP:0003112)1.62229082

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK194.74317849
2NME23.95450638
3MAP3K123.43690569
4VRK23.24050808
5PIM22.52493633
6BUB12.44832147
7MST42.34018572
8EIF2AK12.31863658
9WEE12.29407515
10MAP4K12.20338483
11LRRK22.05600563
12PDK22.01759219
13RIPK41.95243651
14BRSK21.92023005
15FLT31.90755166
16RPS6KB21.87640482
17MAP3K141.85537530
18PBK1.85049648
19ERBB31.85032019
20OBSCN1.67339819
21STK101.62778451
22TYK21.61627115
23NME11.60057799
24IRAK41.55981250
25IKBKB1.53401889
26STK161.52751448
27EPHA21.49839547
28TBK11.49060456
29SIK31.47406556
30WNK31.46565870
31RPS6KA41.43386150
32TESK21.42644268
33BMPR21.42224941
34ZAP701.33556701
35CDC71.32771875
36KIT1.31798450
37TRIM281.30422440
38VRK11.27381179
39DYRK31.25593055
40PIM11.24894609
41NEK91.24807925
42AURKB1.23689112
43BCKDK1.23283175
44SRPK11.23059731
45TXK1.22974510
46TTK1.21430620
47NEK21.20163856
48TGFBR11.18953328
49STK41.16711249
50PHKG11.15038863
51PHKG21.15038863
52JAK31.14876985
53TEC1.14491717
54TLK11.13837844
55PKN21.12763879
56CSF1R1.07485316
57CDK41.06746083
58IKBKE1.05745515
59CDK71.03568212
60DYRK21.03509639
61EIF2AK31.00701854
62MAP3K81.00257360
63PINK10.99666652
64IRAK30.96273593
65DAPK30.96056686
66PLK40.94374578
67PASK0.94182465
68ACVR1B0.93798233
69CHUK0.92393834
70DAPK10.91458276
71ABL20.90447691
72BTK0.90249445
73CDK60.89682247
74CAMKK20.89474670
75NLK0.87543346
76PLK10.85866689
77MAP2K30.85089328
78TSSK60.84664546
79EIF2AK20.84378492
80BCR0.82055768
81BMPR1B0.80703322
82BLK0.80257892
83FGFR40.79181250
84TAOK30.78720230
85MKNK10.77397312
86KDR0.76599359
87ATR0.74922690
88TGFBR20.73674386
89ERN10.71020350
90EEF2K0.70299812
91NEK10.69052761
92CLK10.68971670
93LMTK20.68857853
94STK240.67768067
95BRAF0.66826444
96STK30.66055371
97MAP2K70.65741304
98MAP2K20.65701533
99RPS6KA50.65215947
100TESK10.64550081
101LYN0.64370152
102PIK3CA0.64202881
103ILK0.64110985
104ITK0.62962516
105GRK50.61786198
106MAP3K30.61457112
107FGR0.61448816
108MST1R0.61391727
109GRK60.61131413
110PLK30.60169157
111CSNK2A10.58847425
112MATK0.58801843
113OXSR10.57970421
114MAP3K110.57028122
115ZAK0.56651119
116CSNK2A20.55931095
117MAPKAPK20.54844418
118NUAK10.54591111
119PAK20.54287284
120KSR10.54110721
121TRPM70.53780842
122BRSK10.53245987
123LCK0.52535891
124ARAF0.52494370
125PRKCQ0.51849880
126CHEK20.51613340
127PIK3CG0.50922997
128SYK0.50454925
129MARK30.49668820
130MAP3K20.48432270
131MAPK110.47740448
132DYRK1B0.47685662
133JAK10.44582775
134PAK40.43510121
135MAP3K40.42948476
136PAK10.42680114
137PRKCD0.42235687
138MYLK0.41054322
139TNK20.39807242
140CDK80.39454850
141HCK0.39331459
142MAPKAPK30.36008578
143TAF10.34499845
144CSK0.32481572
145CSNK1G20.31648714
146CSNK1G30.30797777
147FES0.29238589
148STK390.28103962
149MAP2K10.27238523
150RPS6KB10.25663072

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.77665766
2DNA replication_Homo sapiens_hsa030302.76796140
3Proteasome_Homo sapiens_hsa030502.64626267
4Alzheimers disease_Homo sapiens_hsa050102.33606373
5Mismatch repair_Homo sapiens_hsa034302.26881700
6RNA polymerase_Homo sapiens_hsa030202.19979905
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.02187324
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.99528945
9One carbon pool by folate_Homo sapiens_hsa006701.95768869
10Base excision repair_Homo sapiens_hsa034101.80466826
11Regulation of autophagy_Homo sapiens_hsa041401.77743503
12Homologous recombination_Homo sapiens_hsa034401.75365781
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.74992092
14Spliceosome_Homo sapiens_hsa030401.73453421
15Pyrimidine metabolism_Homo sapiens_hsa002401.69967839
16Autoimmune thyroid disease_Homo sapiens_hsa053201.60925436
17Folate biosynthesis_Homo sapiens_hsa007901.45746577
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.45572001
19Type I diabetes mellitus_Homo sapiens_hsa049401.41145452
20SNARE interactions in vesicular transport_Homo sapiens_hsa041301.38789819
21Nucleotide excision repair_Homo sapiens_hsa034201.38115796
22Allograft rejection_Homo sapiens_hsa053301.34138395
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.33382970
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.33063921
25Non-homologous end-joining_Homo sapiens_hsa034501.32184777
26Cardiac muscle contraction_Homo sapiens_hsa042601.30894338
27RNA transport_Homo sapiens_hsa030131.29264117
28Protein export_Homo sapiens_hsa030601.20801693
29Primary immunodeficiency_Homo sapiens_hsa053401.15146814
30Pentose and glucuronate interconversions_Homo sapiens_hsa000401.14257260
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.12996679
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.12139505
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.10071651
34Glutathione metabolism_Homo sapiens_hsa004801.08102014
35Sulfur relay system_Homo sapiens_hsa041221.07587325
36Fat digestion and absorption_Homo sapiens_hsa049751.06464670
37Graft-versus-host disease_Homo sapiens_hsa053321.05289067
38Fatty acid degradation_Homo sapiens_hsa000711.04508279
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04240648
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.02612581
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02547429
42Legionellosis_Homo sapiens_hsa051341.02149148
43Selenocompound metabolism_Homo sapiens_hsa004501.00656351
44Collecting duct acid secretion_Homo sapiens_hsa049660.99461851
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.99386146
46Pentose phosphate pathway_Homo sapiens_hsa000300.99311823
47Antigen processing and presentation_Homo sapiens_hsa046120.99301188
48Herpes simplex infection_Homo sapiens_hsa051680.98864275
49Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.98011620
50Parkinsons disease_Homo sapiens_hsa050120.97582135
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.97472939
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.96198328
53Caffeine metabolism_Homo sapiens_hsa002320.95366736
54Histidine metabolism_Homo sapiens_hsa003400.92723790
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92628248
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92345034
57Peroxisome_Homo sapiens_hsa041460.91905702
58NOD-like receptor signaling pathway_Homo sapiens_hsa046210.91695817
59Systemic lupus erythematosus_Homo sapiens_hsa053220.91234789
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90005337
61p53 signaling pathway_Homo sapiens_hsa041150.89370402
62Oxidative phosphorylation_Homo sapiens_hsa001900.89304249
63Cell cycle_Homo sapiens_hsa041100.87654036
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87560659
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.87008856
66Chemical carcinogenesis_Homo sapiens_hsa052040.86554334
67Leishmaniasis_Homo sapiens_hsa051400.86097345
68Sulfur metabolism_Homo sapiens_hsa009200.85616069
69Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.84615363
70Measles_Homo sapiens_hsa051620.84505913
71RNA degradation_Homo sapiens_hsa030180.83126947
72beta-Alanine metabolism_Homo sapiens_hsa004100.82636981
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79188220
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78681986
75Renin-angiotensin system_Homo sapiens_hsa046140.78174307
76Propanoate metabolism_Homo sapiens_hsa006400.77927459
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77728009
78Carbon metabolism_Homo sapiens_hsa012000.77434453
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73130556
80Staphylococcus aureus infection_Homo sapiens_hsa051500.72368507
81Tryptophan metabolism_Homo sapiens_hsa003800.70646782
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70359325
83Retinol metabolism_Homo sapiens_hsa008300.69824328
84Fanconi anemia pathway_Homo sapiens_hsa034600.69606222
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68817027
86Metabolic pathways_Homo sapiens_hsa011000.68741907
87Basal transcription factors_Homo sapiens_hsa030220.68280174
88Epstein-Barr virus infection_Homo sapiens_hsa051690.65376280
89Phenylalanine metabolism_Homo sapiens_hsa003600.65216826
90Pancreatic secretion_Homo sapiens_hsa049720.65200180
91Biosynthesis of amino acids_Homo sapiens_hsa012300.65158905
92Steroid biosynthesis_Homo sapiens_hsa001000.64967165
93Purine metabolism_Homo sapiens_hsa002300.63368721
94Pertussis_Homo sapiens_hsa051330.62806072
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.61532693
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61037950
97Fatty acid elongation_Homo sapiens_hsa000620.60758848
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60731371
99Rheumatoid arthritis_Homo sapiens_hsa053230.59995454
100Tyrosine metabolism_Homo sapiens_hsa003500.59678690
101Asthma_Homo sapiens_hsa053100.58879038
102Toll-like receptor signaling pathway_Homo sapiens_hsa046200.57331977
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.56982361
104Arachidonic acid metabolism_Homo sapiens_hsa005900.56147497
105Apoptosis_Homo sapiens_hsa042100.54881645
106Hematopoietic cell lineage_Homo sapiens_hsa046400.54730894
107Huntingtons disease_Homo sapiens_hsa050160.54185117
108Arginine and proline metabolism_Homo sapiens_hsa003300.53471295
109Complement and coagulation cascades_Homo sapiens_hsa046100.53169203
110Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52945772
111Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51896136
112Pyruvate metabolism_Homo sapiens_hsa006200.49774243
113Starch and sucrose metabolism_Homo sapiens_hsa005000.49312132
114Vitamin B6 metabolism_Homo sapiens_hsa007500.49041746
115Influenza A_Homo sapiens_hsa051640.49006883
116Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47518670
117Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47371423
118Viral myocarditis_Homo sapiens_hsa054160.47042823
119Arginine biosynthesis_Homo sapiens_hsa002200.46686304
120Shigellosis_Homo sapiens_hsa051310.46383118
121Fructose and mannose metabolism_Homo sapiens_hsa000510.43362240
122Galactose metabolism_Homo sapiens_hsa000520.42281595
123Maturity onset diabetes of the young_Homo sapiens_hsa049500.39329795
124Vibrio cholerae infection_Homo sapiens_hsa051100.34270675
125Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27668996
126Sphingolipid metabolism_Homo sapiens_hsa006000.25507240
127Ether lipid metabolism_Homo sapiens_hsa005650.23152207
128Tuberculosis_Homo sapiens_hsa051520.22387443
129Butanoate metabolism_Homo sapiens_hsa006500.22064588
130alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21063321

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