IFT27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a GTP-binding protein that is a core component of the intraflagellar transport complex B. Characterization of the similar Chlamydomonas protein indicates a function in cell cycle control. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)9.74502254
2epithelial cilium movement (GO:0003351)9.56164162
3motile cilium assembly (GO:0044458)8.64649771
4DNA deamination (GO:0045006)8.51801846
5proline metabolic process (GO:0006560)7.25822668
6transcription from mitochondrial promoter (GO:0006390)7.04309431
7replication fork processing (GO:0031297)7.00538574
8left/right pattern formation (GO:0060972)6.84851643
9axoneme assembly (GO:0035082)6.83227812
10regulation of cilium movement (GO:0003352)6.42481861
11maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)6.16892131
12viral mRNA export from host cell nucleus (GO:0046784)6.12763463
13telomere maintenance via semi-conservative replication (GO:0032201)5.80215679
14positive regulation of protein homooligomerization (GO:0032464)5.76676857
15intraciliary transport (GO:0042073)5.73374200
16oxidative demethylation (GO:0070989)5.69707571
17embryonic process involved in female pregnancy (GO:0060136)5.60903156
18DNA strand renaturation (GO:0000733)5.44340125
19somatic diversification of immune receptors via somatic mutation (GO:0002566)5.13907353
20somatic hypermutation of immunoglobulin genes (GO:0016446)5.13907353
21nucleotide-excision repair, DNA gap filling (GO:0006297)4.96510915
22establishment of apical/basal cell polarity (GO:0035089)4.94348651
23regulation of protein homooligomerization (GO:0032462)4.89451574
24pyrimidine nucleobase catabolic process (GO:0006208)4.88322543
25formation of translation preinitiation complex (GO:0001731)4.86696910
26DNA strand elongation involved in DNA replication (GO:0006271)4.86053510
27telomere maintenance via recombination (GO:0000722)4.79060992
28microtubule bundle formation (GO:0001578)4.68551482
29base-excision repair (GO:0006284)4.64423935
30negative regulation of cell cycle arrest (GO:0071157)4.63624455
31base-excision repair, AP site formation (GO:0006285)4.61717239
32DNA strand elongation (GO:0022616)4.58839078
33left/right axis specification (GO:0070986)4.55710728
34cilium organization (GO:0044782)4.54652030
35mitochondrial DNA metabolic process (GO:0032042)4.53589676
36pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.53512109
37cilium assembly (GO:0042384)4.49372239
38regulation of microtubule-based movement (GO:0060632)4.48153147
39DNA integration (GO:0015074)4.47128153
40regulation of integrin activation (GO:0033623)4.45526437
41DNA double-strand break processing (GO:0000729)4.45136753
42ventricular system development (GO:0021591)4.43497162
43establishment of protein localization to mitochondrial membrane (GO:0090151)4.42707907
44poly(A)+ mRNA export from nucleus (GO:0016973)4.41036011
45establishment of monopolar cell polarity (GO:0061162)4.37309085
46establishment or maintenance of monopolar cell polarity (GO:0061339)4.37309085
47protein localization to cilium (GO:0061512)4.19794504
48nonmotile primary cilium assembly (GO:0035058)4.13343030
49negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.12675297
50mitotic recombination (GO:0006312)4.11597717
51negative regulation of JAK-STAT cascade (GO:0046426)4.02794115
52DNA ligation (GO:0006266)3.91657202
53mRNA cleavage (GO:0006379)3.90044121
54cullin deneddylation (GO:0010388)3.89730956
55telomere maintenance via telomere lengthening (GO:0010833)3.89645845
56cell migration in hindbrain (GO:0021535)3.85248511
57termination of RNA polymerase II transcription (GO:0006369)3.84901306
58mitotic G1 DNA damage checkpoint (GO:0031571)3.82918765
59regulation of double-strand break repair via homologous recombination (GO:0010569)3.80749266
60maturation of 5.8S rRNA (GO:0000460)3.77543531
61cellular response to zinc ion (GO:0071294)3.74825754
62positive regulation of developmental pigmentation (GO:0048087)3.74376649
63cilium morphogenesis (GO:0060271)3.72648671
64pyrimidine nucleotide catabolic process (GO:0006244)3.71866621
65positive regulation of DNA repair (GO:0045739)3.70725853
66negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.70108567
67non-recombinational repair (GO:0000726)3.69516805
68double-strand break repair via nonhomologous end joining (GO:0006303)3.69516805
69protein deneddylation (GO:0000338)3.68079735
70mitochondrial RNA metabolic process (GO:0000959)3.67054364
71GDP-mannose metabolic process (GO:0019673)3.65876241
72kinetochore assembly (GO:0051382)3.57168370
73negative regulation of mRNA processing (GO:0050686)3.57052910
74nucleobase catabolic process (GO:0046113)3.56707824
75microtubule-based movement (GO:0007018)3.54960446
76dosage compensation (GO:0007549)3.54728563
77DNA topological change (GO:0006265)3.51550120
78cellular component assembly involved in morphogenesis (GO:0010927)3.48884818
79negative regulation of RNA splicing (GO:0033119)3.47043651
80regulation of translational fidelity (GO:0006450)3.46007628
81glutamine family amino acid biosynthetic process (GO:0009084)3.45367220
82negative regulation of T cell differentiation in thymus (GO:0033085)3.44486376
83cellular response to ATP (GO:0071318)3.39163980
84meiotic chromosome segregation (GO:0045132)3.34590063
85DNA demethylation (GO:0080111)3.34234384
86G1 DNA damage checkpoint (GO:0044783)3.33474112
87mitotic G1/S transition checkpoint (GO:0044819)3.32142905
88pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.30384132
89spliceosomal tri-snRNP complex assembly (GO:0000244)3.29497245
90protein neddylation (GO:0045116)3.28491245
91nuclear envelope reassembly (GO:0031468)3.23704501
92mitotic nuclear envelope reassembly (GO:0007084)3.23704501
93substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.21239624
94substrate-independent telencephalic tangential migration (GO:0021826)3.21239624
95primary alcohol catabolic process (GO:0034310)3.18186371
96cerebellar granule cell differentiation (GO:0021707)3.15319663
97regulation of double-strand break repair (GO:2000779)3.13962439
98positive regulation of protein oligomerization (GO:0032461)3.12109575
99positive regulation by host of viral transcription (GO:0043923)3.11903767
100kinetochore organization (GO:0051383)3.09620422
101establishment of mitochondrion localization (GO:0051654)3.08879478
102pseudouridine synthesis (GO:0001522)3.08112571
103negative regulation of protein oligomerization (GO:0032460)3.07562593
104transmission of nerve impulse (GO:0019226)3.05366325
105cell projection assembly (GO:0030031)3.05357762
106nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.01807948
107establishment of planar polarity (GO:0001736)3.01739860
108establishment of tissue polarity (GO:0007164)3.01739860
109proteasome assembly (GO:0043248)3.01028462
110glial cell migration (GO:0008347)2.99933957
111axonal fasciculation (GO:0007413)2.99627934
112convergent extension (GO:0060026)2.99552487
113epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.97517424
114lung epithelium development (GO:0060428)2.95765975
115embryonic camera-type eye development (GO:0031076)2.95553016
116transcription-coupled nucleotide-excision repair (GO:0006283)2.94461341
117regulation of autophagic vacuole assembly (GO:2000785)2.93916438
118viral transcription (GO:0019083)2.93617874
119regulation of sister chromatid cohesion (GO:0007063)2.93211833
120regulation of DNA damage checkpoint (GO:2000001)2.93152378
121embryonic placenta development (GO:0001892)2.91964465
122regulation of collateral sprouting (GO:0048670)2.90872729
123regulation of protein oligomerization (GO:0032459)2.90773732
124single strand break repair (GO:0000012)2.90769536
125nucleoside diphosphate phosphorylation (GO:0006165)2.90183519
126mitochondrial DNA replication (GO:0006264)2.88132019
127negative regulation of mRNA metabolic process (GO:1903312)2.87415173
128DNA replication initiation (GO:0006270)2.84529648
129protein polyglutamylation (GO:0018095)2.84256784
130spliceosomal snRNP assembly (GO:0000387)2.84202773
131regulation of DNA repair (GO:0006282)2.83906487
132face development (GO:0060324)2.83305920
133lateral ventricle development (GO:0021670)2.82579775
134mRNA polyadenylation (GO:0006378)2.80681510
135DNA dealkylation (GO:0035510)2.79926897
136neuron recognition (GO:0008038)2.79598876
137translational initiation (GO:0006413)2.79272851
138resolution of meiotic recombination intermediates (GO:0000712)2.78834322
139ethanol metabolic process (GO:0006067)2.76657782
140vitamin transmembrane transport (GO:0035461)2.76507025
141neuronal ion channel clustering (GO:0045161)2.76237564
142centriole assembly (GO:0098534)2.75026873
143neurotransmitter catabolic process (GO:0042135)2.73509590
144short-term memory (GO:0007614)2.71896347
145regulation of respiratory system process (GO:0044065)2.71858295
146phenol-containing compound catabolic process (GO:0019336)2.67885435
147smoothened signaling pathway (GO:0007224)2.66356264
148cytoplasmic microtubule organization (GO:0031122)2.65861543
149axon extension involved in axon guidance (GO:0048846)2.65318731
150neuron projection extension involved in neuron projection guidance (GO:1902284)2.65318731
151ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.65089894
152presynaptic membrane organization (GO:0097090)2.62570843
153lateral sprouting from an epithelium (GO:0060601)2.61342001
154determination of left/right symmetry (GO:0007368)2.58422446
155GTP biosynthetic process (GO:0006183)2.54774491
156regulation of vacuole organization (GO:0044088)2.49952297
157behavioral response to nicotine (GO:0035095)2.49894254
158positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.49629974
159mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.49629974
160positive regulation of smoothened signaling pathway (GO:0045880)2.49550120
161apical protein localization (GO:0045176)2.48353432
162synaptic transmission, glutamatergic (GO:0035249)2.48138768
163epithelial cell differentiation involved in kidney development (GO:0035850)2.47544363
164negative regulation of cytosolic calcium ion concentration (GO:0051481)2.45660559
165asymmetric protein localization (GO:0008105)2.42800884
166regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.42379098
167response to xenobiotic stimulus (GO:0009410)2.42096723
168positive regulation of synapse assembly (GO:0051965)2.42028218
169vocalization behavior (GO:0071625)2.41433791
170adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.39766425
171retinal rod cell development (GO:0046548)2.39659363
172neurofilament cytoskeleton organization (GO:0060052)2.39534253
173microtubule severing (GO:0051013)2.38987647
174determination of bilateral symmetry (GO:0009855)2.38968428
175postsynaptic membrane organization (GO:0001941)2.36208810
176cranial nerve morphogenesis (GO:0021602)2.35787351
177neurotransmitter metabolic process (GO:0042133)2.35065271
178auditory behavior (GO:0031223)2.34943640
179presynaptic membrane assembly (GO:0097105)2.34077452
180striatum development (GO:0021756)2.33900063
181head development (GO:0060322)2.33227182
182regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.31958172
183specification of symmetry (GO:0009799)2.30611263
184embryonic body morphogenesis (GO:0010172)2.30451780
185positive regulation of protein homodimerization activity (GO:0090073)2.30166750
186gamma-aminobutyric acid transport (GO:0015812)2.30134138
187regulation of synapse structural plasticity (GO:0051823)2.28518141
188limb development (GO:0060173)2.27763744
189appendage development (GO:0048736)2.27763744
190aldehyde catabolic process (GO:0046185)2.27303223
191axonemal dynein complex assembly (GO:0070286)12.8205611
192cilium movement (GO:0003341)10.2317792
193cilium or flagellum-dependent cell motility (GO:0001539)10.1717282

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.94224551
2EZH2_22144423_ChIP-Seq_EOC_Human5.20574702
3E2F7_22180533_ChIP-Seq_HELA_Human4.70189939
4CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.91987860
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.81060575
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.67294993
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.55789220
8MYC_18358816_ChIP-ChIP_MESCs_Mouse2.97350702
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.80958146
10CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.68377575
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.66336132
12ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.63037349
13DROSHA_22980978_ChIP-Seq_HELA_Human2.54712726
14EZH2_27294783_Chip-Seq_ESCs_Mouse2.46710754
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.44719447
16SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.41464839
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.36522351
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.35666102
19VDR_21846776_ChIP-Seq_THP-1_Human2.29478343
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.28819966
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.28546978
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.26347596
23YY1_21170310_ChIP-Seq_MESCs_Mouse2.19308532
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.16961865
25JARID2_20075857_ChIP-Seq_MESCs_Mouse2.14119015
26JARID2_20064375_ChIP-Seq_MESCs_Mouse2.13247746
27EST1_17652178_ChIP-ChIP_JURKAT_Human2.11172911
28EZH2_27304074_Chip-Seq_ESCs_Mouse2.09918366
29DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.09211044
30GABP_17652178_ChIP-ChIP_JURKAT_Human2.04353946
31KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.03630186
32KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.03630186
33KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.03630186
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.03040993
35E2F1_18555785_ChIP-Seq_MESCs_Mouse2.02181868
36* REST_21632747_ChIP-Seq_MESCs_Mouse1.97202959
37DCP1A_22483619_ChIP-Seq_HELA_Human1.92933042
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.91784037
39CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.91187250
40KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.90337304
41RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89744370
42* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.89013594
43RNF2_27304074_Chip-Seq_ESCs_Mouse1.86376884
44GABP_19822575_ChIP-Seq_HepG2_Human1.86367243
45KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.85499955
46CTCF_27219007_Chip-Seq_Bcells_Human1.83760395
47RNF2_18974828_ChIP-Seq_MESCs_Mouse1.83481466
48EZH2_18974828_ChIP-Seq_MESCs_Mouse1.83481466
49XRN2_22483619_ChIP-Seq_HELA_Human1.83271359
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.80326247
51SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.79794629
52NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.79111160
53E2F4_17652178_ChIP-ChIP_JURKAT_Human1.77497255
54SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.76644411
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.76492608
56PU.1_20513432_ChIP-Seq_Bcells_Mouse1.76385547
57REST_18959480_ChIP-ChIP_MESCs_Mouse1.74274241
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.72289539
59DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.71048427
60FOXM1_23109430_ChIP-Seq_U2OS_Human1.70914301
61SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.69553834
62NELFA_20434984_ChIP-Seq_ESCs_Mouse1.68596800
63IKZF1_21737484_ChIP-ChIP_HCT116_Human1.68553730
64TTF2_22483619_ChIP-Seq_HELA_Human1.68128888
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.64943184
66EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63645240
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.62743446
68P68_20966046_ChIP-Seq_HELA_Human1.62731305
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.62604495
70MYC_22102868_ChIP-Seq_BL_Human1.60205528
71SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.59590272
72SMC4_20622854_ChIP-Seq_HELA_Human1.58655113
73MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.56827344
74VDR_23849224_ChIP-Seq_CD4+_Human1.54007393
75TET1_21451524_ChIP-Seq_MESCs_Mouse1.54003188
76NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.53917072
77LXR_22292898_ChIP-Seq_THP-1_Human1.52857768
78BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.52407301
79SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.50327724
80MYCN_18555785_ChIP-Seq_MESCs_Mouse1.50144289
81POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.50141882
82STAT3_1855785_ChIP-Seq_MESCs_Mouse1.49945947
83TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48255577
84ELF1_20517297_ChIP-Seq_JURKAT_Human1.47971947
85SRF_21415370_ChIP-Seq_HL-1_Mouse1.47497894
86NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.47452376
87MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47439749
88TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.46838391
89CREB1_15753290_ChIP-ChIP_HEK293T_Human1.46654189
90POU5F1_16518401_ChIP-PET_MESCs_Mouse1.46453068
91NANOG_21062744_ChIP-ChIP_HESCs_Human1.44988415
92MTF2_20144788_ChIP-Seq_MESCs_Mouse1.43874493
93TP53_20018659_ChIP-ChIP_R1E_Mouse1.42332738
94SRY_22984422_ChIP-ChIP_TESTIS_Rat1.40029009
95OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.39620204
96POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.39450813
97HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37954609
98SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.37069370
99NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.36974957
100POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.36218629
101CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.36211965
102RNF2_27304074_Chip-Seq_NSC_Mouse1.35663241
103MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34975920
104SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34699372
105TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34158297
106SOX2_18555785_ChIP-Seq_MESCs_Mouse1.33362888
107ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32986951
108PHF8_20622854_ChIP-Seq_HELA_Human1.31636297
109E2F1_21310950_ChIP-Seq_MCF-7_Human1.30878550
110PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29568802
111ZNF274_21170338_ChIP-Seq_K562_Hela1.29481495
112SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28871081
113RING1B_27294783_Chip-Seq_ESCs_Mouse1.28658230
114PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.28538678
115FOXP3_21729870_ChIP-Seq_TREG_Human1.27404208
116TCF3_18692474_ChIP-Seq_MESCs_Mouse1.27053721
117DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26994841
118KDM5A_27292631_Chip-Seq_BREAST_Human1.26660335
119ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26499995
120KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26424853
121TCF3_18692474_ChIP-Seq_MEFs_Mouse1.25056646
122SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.24831166
123CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.24668354
124SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.22951704
125ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22715152
126CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.21935888
127ERG_21242973_ChIP-ChIP_JURKAT_Human1.21330140
128RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19792563
129STAT1_20625510_ChIP-Seq_HELA_Human1.19261400
130CTCF_20526341_ChIP-Seq_ESCs_Human1.19258514
131ETS1_21867929_ChIP-Seq_TH2_Mouse1.18215622
132RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.17865692
133EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17787303
134RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17439756
135RAD21_21589869_ChIP-Seq_MESCs_Mouse1.17193450
136CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16948730
137SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.16580656
138POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.14910964
139KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14758373
140SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13226216
141ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13160412
142NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.12881767
143RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12647053
144SOX2_18692474_ChIP-Seq_MEFs_Mouse1.12161378
145E2F1_20622854_ChIP-Seq_HELA_Human1.11079014
146YY1_22570637_ChIP-Seq_MALME-3M_Human1.10503076
147EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.10273994
148SA1_27219007_Chip-Seq_ERYTHROID_Human1.10015447
149ERA_21632823_ChIP-Seq_H3396_Human1.09780120
150THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09055094
151SOX3_22085726_ChIP-Seq_NPCs_Mouse1.08650985
152SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07974888
153TP63_22573176_ChIP-Seq_HFKS_Human1.07914076
154SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.07367783
155OCT4_18692474_ChIP-Seq_MEFs_Mouse1.06739353
156RARB_24833708_ChIP-Seq_LIVER_Mouse1.06101294
157ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05311316
158SA1_27219007_Chip-Seq_Bcells_Human1.04526098
159STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03830338
160FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03467582
161CTCF_18555785_ChIP-Seq_MESCs_Mouse1.03368933
162IRF1_19129219_ChIP-ChIP_H3396_Human1.02936800
163E2F1_17053090_ChIP-ChIP_MCF-7_Human1.02836474
164GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02130237
165FOXP1_21924763_ChIP-Seq_HESCs_Human1.01637097
166CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01231600
167SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00022137
168CREB1_26743006_Chip-Seq_LNCaP_Human0.99998244
169RXRA_24833708_ChIP-Seq_LIVER_Mouse0.98821768
170BCL6_27268052_Chip-Seq_Bcells_Human0.98063588
171SOX2_21211035_ChIP-Seq_LN229_Human0.97276112
172FLI1_21867929_ChIP-Seq_CD8_Mouse0.96477086
173TRIM28_21343339_ChIP-Seq_HEK293_Human0.94116103
174MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.92444485
175KDM2B_26808549_Chip-Seq_K562_Human0.91637183
176* RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90693312
177NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.90227816
178RARB_27405468_Chip-Seq_BRAIN_Mouse0.88811607
179TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.87778310
180GATA1_26923725_Chip-Seq_HPCs_Mouse0.86439294
181OCT4_19829295_ChIP-Seq_ESCs_Human0.85908756
182CTBP1_25329375_ChIP-Seq_LNCAP_Human0.84873585
183BCOR_27268052_Chip-Seq_Bcells_Human0.84092699
184TET1_21490601_ChIP-Seq_MESCs_Mouse0.81472747
185EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.80905850
186KDM2B_26808549_Chip-Seq_SUP-B15_Human0.80759405
187CTCF_26484167_Chip-Seq_Bcells_Mouse0.80208489

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.43193747
2MP0005171_absent_coat_pigmentation4.39778760
3MP0010030_abnormal_orbit_morphology4.06675436
4MP0009278_abnormal_bone_marrow3.68493885
5MP0001984_abnormal_olfaction3.34331594
6MP0003880_abnormal_central_pattern3.18351780
7MP0010094_abnormal_chromosome_stability3.02199172
8MP0004859_abnormal_synaptic_plasticity2.90389969
9MP0008995_early_reproductive_senescence2.85911044
10MP0005394_taste/olfaction_phenotype2.85632232
11MP0005499_abnormal_olfactory_system2.85632232
12MP0002653_abnormal_ependyma_morphology2.66582457
13MP0000778_abnormal_nervous_system2.55329536
14MP0002009_preneoplasia2.50928215
15MP0004233_abnormal_muscle_weight2.50577228
16MP0003786_premature_aging2.47476055
17MP0008058_abnormal_DNA_repair2.47136148
18MP0004133_heterotaxia2.44191487
19MP0004957_abnormal_blastocyst_morpholog2.43684363
20MP0005397_hematopoietic_system_phenotyp2.41101341
21MP0001545_abnormal_hematopoietic_system2.41101341
22MP0003878_abnormal_ear_physiology2.37948221
23MP0005377_hearing/vestibular/ear_phenot2.37948221
24MP0002822_catalepsy2.36695569
25MP0003283_abnormal_digestive_organ2.24040973
26MP0005423_abnormal_somatic_nervous2.21368431
27MP0003787_abnormal_imprinting2.20807629
28MP0008877_abnormal_DNA_methylation2.16725712
29MP0005174_abnormal_tail_pigmentation2.12708621
30MP0003111_abnormal_nucleus_morphology2.03931732
31MP0008932_abnormal_embryonic_tissue2.01012071
32MP0003122_maternal_imprinting1.99641634
33MP0000566_synostosis1.99452365
34MP0006072_abnormal_retinal_apoptosis1.93386489
35MP0002249_abnormal_larynx_morphology1.93123212
36MP0008875_abnormal_xenobiotic_pharmacok1.92999723
37MP0003635_abnormal_synaptic_transmissio1.88965251
38MP0003890_abnormal_embryonic-extraembry1.86977696
39MP0003077_abnormal_cell_cycle1.85317985
40MP0006276_abnormal_autonomic_nervous1.81530921
41MP0000955_abnormal_spinal_cord1.77109551
42MP0003693_abnormal_embryo_hatching1.75594323
43MP0002282_abnormal_trachea_morphology1.74466897
44MP0000490_abnormal_crypts_of1.74122148
45MP0002102_abnormal_ear_morphology1.72850543
46MP0005075_abnormal_melanosome_morpholog1.71475393
47MP0001529_abnormal_vocalization1.69230552
48MP0002734_abnormal_mechanical_nocicepti1.67993709
49MP0000015_abnormal_ear_pigmentation1.62313155
50MP0001188_hyperpigmentation1.61257794
51MP0002572_abnormal_emotion/affect_behav1.60441370
52MP0002735_abnormal_chemical_nociception1.55485284
53MP0002277_abnormal_respiratory_mucosa1.54631358
54MP0005623_abnormal_meninges_morphology1.53579304
55MP0001502_abnormal_circadian_rhythm1.53285797
56MP0002557_abnormal_social/conspecific_i1.53172400
57MP0002063_abnormal_learning/memory/cond1.51609369
58MP0003119_abnormal_digestive_system1.51558099
59MP0001293_anophthalmia1.50277903
60MP0002272_abnormal_nervous_system1.49737742
61MP0004885_abnormal_endolymph1.48864543
62MP0002638_abnormal_pupillary_reflex1.46600187
63MP0000026_abnormal_inner_ear1.41310775
64MP0002882_abnormal_neuron_morphology1.38799051
65MP0001970_abnormal_pain_threshold1.38301854
66MP0001486_abnormal_startle_reflex1.31910895
67MP0009745_abnormal_behavioral_response1.30934513
68MP0001270_distended_abdomen1.30923114
69MP0001697_abnormal_embryo_size1.28302359
70MP0005645_abnormal_hypothalamus_physiol1.24203737
71MP0002019_abnormal_tumor_incidence1.24187813
72MP0003136_yellow_coat_color1.23978856
73MP0001299_abnormal_eye_distance/1.23955806
74MP0002752_abnormal_somatic_nervous1.23942713
75MP0000631_abnormal_neuroendocrine_gland1.23291673
76MP0002064_seizures1.23041755
77MP0002184_abnormal_innervation1.23023229
78MP0002152_abnormal_brain_morphology1.22644728
79MP0003861_abnormal_nervous_system1.21946346
80MP0003938_abnormal_ear_development1.21805325
81MP0000470_abnormal_stomach_morphology1.21151456
82MP0002085_abnormal_embryonic_tissue1.20974505
83MP0009046_muscle_twitch1.20553873
84MP0001968_abnormal_touch/_nociception1.20123884
85MP0004811_abnormal_neuron_physiology1.18888208
86MP0002160_abnormal_reproductive_system1.18319439
87MP0004142_abnormal_muscle_tone1.17585457
88MP0005551_abnormal_eye_electrophysiolog1.17518028
89MP0002084_abnormal_developmental_patter1.17443803
90MP0004270_analgesia1.17404662
91MP0001905_abnormal_dopamine_level1.16782170
92MP0000350_abnormal_cell_proliferation1.16760963
93MP0009333_abnormal_splenocyte_physiolog1.15314745
94MP0008007_abnormal_cellular_replicative1.14854871
95MP0002132_abnormal_respiratory_system1.13973902
96MP0000049_abnormal_middle_ear1.13883813
97MP0002233_abnormal_nose_morphology1.11304687
98MP0003453_abnormal_keratinocyte_physiol1.10728469
99MP0003656_abnormal_erythrocyte_physiolo1.09910590
100MP0004043_abnormal_pH_regulation1.09572902
101MP0002733_abnormal_thermal_nociception1.09455089
102MP0000371_diluted_coat_color1.09337551
103MP0003121_genomic_imprinting1.07511044
104MP0004197_abnormal_fetal_growth/weight/1.07205107
105MP0002086_abnormal_extraembryonic_tissu1.06988237
106MP0002111_abnormal_tail_morphology1.04731490
107MP0002396_abnormal_hematopoietic_system1.04078731
108MP0002405_respiratory_system_inflammati1.03744907
109MP0002751_abnormal_autonomic_nervous1.03371192
110MP0003172_abnormal_lysosome_physiology1.03217737
111MP0000639_abnormal_adrenal_gland1.03205170
112MP0001485_abnormal_pinna_reflex1.02682945
113MP0002067_abnormal_sensory_capabilities1.01422559
114MP0001963_abnormal_hearing_physiology1.00610752
115MP0002932_abnormal_joint_morphology0.99958531
116MP0001340_abnormal_eyelid_morphology0.99671342
117MP0009379_abnormal_foot_pigmentation0.99176361
118MP0003763_abnormal_thymus_physiology0.98680663
119MP0006292_abnormal_olfactory_placode0.97500559
120MP0002909_abnormal_adrenal_gland0.95448711
121MP0005058_abnormal_lysosome_morphology0.95390563
122MP0004147_increased_porphyrin_level0.95255903
123MP0000685_abnormal_immune_system0.95247979
124MP0000313_abnormal_cell_death0.94495048
125MP0004742_abnormal_vestibular_system0.93961365
126MP0010352_gastrointestinal_tract_polyps0.93170103
127MP0002075_abnormal_coat/hair_pigmentati0.92603254
128MP0009780_abnormal_chondrocyte_physiolo0.91820943
129MP0004858_abnormal_nervous_system0.90140318
130MP0002066_abnormal_motor_capabilities/c0.89907033
131MP0009384_cardiac_valve_regurgitation0.89320755
132MP0002080_prenatal_lethality0.87585134
133MP0002069_abnormal_eating/drinking_beha0.87318033
134MP0002114_abnormal_axial_skeleton0.86797446
135MP0005380_embryogenesis_phenotype0.86789113
136MP0001672_abnormal_embryogenesis/_devel0.86789113
137MP0001186_pigmentation_phenotype0.86681117
138MP0005646_abnormal_pituitary_gland0.86555943
139MP0005195_abnormal_posterior_eye0.86111475
140MP0003567_abnormal_fetal_cardiomyocyte0.82863291
141MP0002116_abnormal_craniofacial_bone0.82184987
142MP0008789_abnormal_olfactory_epithelium0.81819539
143MP0005266_abnormal_metabolism0.81230175
144MP0001730_embryonic_growth_arrest0.81185529
145MP0000689_abnormal_spleen_morphology0.81107209
146MP0000762_abnormal_tongue_morphology0.79993244
147MP0001324_abnormal_eye_pigmentation0.78815158
148MP0005253_abnormal_eye_physiology0.78259788
149MP0005076_abnormal_cell_differentiation0.77658692
150MP0002163_abnormal_gland_morphology0.77131816
151MP0001145_abnormal_male_reproductive0.77002805
152MP0002938_white_spotting0.76490296
153MP0003755_abnormal_palate_morphology0.76126380
154MP0000534_abnormal_ureter_morphology0.73926307
155MP0000579_abnormal_nail_morphology0.73151707
156MP0002736_abnormal_nociception_after0.72481368
157MP0003879_abnormal_hair_cell0.71483476
158MP0002928_abnormal_bile_duct0.71025352
159MP0000462_abnormal_digestive_system0.70930725
160MP0005386_behavior/neurological_phenoty0.70448737
161MP0004924_abnormal_behavior0.70448737
162MP0002229_neurodegeneration0.69447086
163MP0003937_abnormal_limbs/digits/tail_de0.68285963
164MP0003137_abnormal_impulse_conducting0.66855651
165MP0003942_abnormal_urinary_system0.66821668
166MP0002269_muscular_atrophy0.66373131
167MP0003718_maternal_effect0.66223664
168MP0008569_lethality_at_weaning0.65736570
169MP0004134_abnormal_chest_morphology0.65301994
170MP0002210_abnormal_sex_determination0.64880021
171MP0001440_abnormal_grooming_behavior0.64582621
172MP0003186_abnormal_redox_activity0.64461702
173MP0008260_abnormal_autophagy0.64362126
174MP0010386_abnormal_urinary_bladder0.64173819
175MP0005391_vision/eye_phenotype0.62304656
176MP0000703_abnormal_thymus_morphology0.61546305
177MP0002398_abnormal_bone_marrow0.60724866
178MP0009115_abnormal_fat_cell0.60710189
179MP0000681_abnormal_thyroid_gland0.60126656
180MP0003935_abnormal_craniofacial_develop0.58660843
181MP0003984_embryonic_growth_retardation0.57964559
182MP0003943_abnormal_hepatobiliary_system0.57364577

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.77334802
2Abnormal respiratory motile cilium physiology (HP:0012261)8.70989418
3Abnormal ciliary motility (HP:0012262)8.57193554
4Dynein arm defect of respiratory motile cilia (HP:0012255)8.50681537
5Absent/shortened dynein arms (HP:0200106)8.50681537
6Rhinitis (HP:0012384)7.64307500
7Chronic bronchitis (HP:0004469)5.64523608
8Bronchiectasis (HP:0002110)5.31828422
9Concave nail (HP:0001598)5.09812777
10Rib fusion (HP:0000902)4.92419483
11Nasal polyposis (HP:0100582)4.75297863
12Increased IgM level (HP:0003496)4.62296439
13Rectal fistula (HP:0100590)4.45901396
14Rectovaginal fistula (HP:0000143)4.45901396
15Annular pancreas (HP:0001734)4.37508480
16Facial hemangioma (HP:0000329)4.30954401
17Poikiloderma (HP:0001029)4.24923253
18Occipital encephalocele (HP:0002085)4.21017276
19Pustule (HP:0200039)3.99998410
20Vaginal fistula (HP:0004320)3.91764435
21Intestinal fistula (HP:0100819)3.89492716
22Tongue fasciculations (HP:0001308)3.88821430
23Abnormality of the nasal mucosa (HP:0000433)3.81325568
24Pancreatic fibrosis (HP:0100732)3.81317867
25Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.79135519
26True hermaphroditism (HP:0010459)3.71032230
27Abnormality of midbrain morphology (HP:0002418)3.60894527
28Molar tooth sign on MRI (HP:0002419)3.60894527
29Selective tooth agenesis (HP:0001592)3.52814979
30Intestinal atresia (HP:0011100)3.50835335
31Nephronophthisis (HP:0000090)3.49907497
32Infertility (HP:0000789)3.48669285
33Patellar aplasia (HP:0006443)3.43794938
34Muscle fibrillation (HP:0010546)3.36526341
35Absent thumb (HP:0009777)3.36160916
36Broad alveolar ridges (HP:0000187)3.26075781
37Recurrent sinusitis (HP:0011108)3.23406385
38Abnormality of male internal genitalia (HP:0000022)3.18926955
39Pancreatic cysts (HP:0001737)3.18827617
40Premature graying of hair (HP:0002216)3.18512581
41Aplasia/Hypoplasia of the patella (HP:0006498)3.14499066
42Atelectasis (HP:0100750)3.13672964
43Myokymia (HP:0002411)3.12585954
44Coronal craniosynostosis (HP:0004440)3.12530866
45Abnormal number of incisors (HP:0011064)3.10063049
46Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.09290398
47Vertebral hypoplasia (HP:0008417)3.09290398
48Turricephaly (HP:0000262)3.09177592
49Absent radius (HP:0003974)3.07947613
50Ulnar bowing (HP:0003031)3.06841305
51Orthostatic hypotension (HP:0001278)3.03766448
52Chronic sinusitis (HP:0011109)3.02259600
53Cystic liver disease (HP:0006706)3.01534854
54Aplasia involving forearm bones (HP:0009822)2.96905676
55Absent forearm bone (HP:0003953)2.96905676
56Abnormal respiratory epithelium morphology (HP:0012253)2.96463521
57Abnormal respiratory motile cilium morphology (HP:0005938)2.96463521
58Hypochromic microcytic anemia (HP:0004840)2.94341970
59Squamous cell carcinoma (HP:0002860)2.93908147
60Abnormal hemoglobin (HP:0011902)2.91742742
61Alopecia of scalp (HP:0002293)2.89772071
62Alacrima (HP:0000522)2.89136074
63Congenital hip dislocation (HP:0001374)2.86829034
64Recurrent otitis media (HP:0000403)2.86167060
65* Medial flaring of the eyebrow (HP:0010747)2.85890223
66Urinary glycosaminoglycan excretion (HP:0003541)2.84394188
67Mucopolysacchariduria (HP:0008155)2.84394188
68Bifid uvula (HP:0000193)2.80735285
69Postaxial foot polydactyly (HP:0001830)2.78803738
70Anteriorly placed anus (HP:0001545)2.78231799
71* Gait imbalance (HP:0002141)2.76918332
72Exertional dyspnea (HP:0002875)2.76481517
73Abnormality of the aortic arch (HP:0012303)2.73524765
74Redundant skin (HP:0001582)2.73457295
75Bronchitis (HP:0012387)2.72926154
76Muscle fiber atrophy (HP:0100295)2.69792931
77Male infertility (HP:0003251)2.67383311
78Aplasia/hypoplasia of the humerus (HP:0006507)2.67135604
79Albinism (HP:0001022)2.67088434
80Basal cell carcinoma (HP:0002671)2.66647344
81Large for gestational age (HP:0001520)2.66478157
82Dysostosis multiplex (HP:0000943)2.64939716
83Chronic hepatic failure (HP:0100626)2.63161223
84Hypoplasia of the radius (HP:0002984)2.59697461
85Narrow nasal bridge (HP:0000446)2.59336882
86Short humerus (HP:0005792)2.58228131
87* Congenital primary aphakia (HP:0007707)2.57884169
88Premature skin wrinkling (HP:0100678)2.55799335
89Joint stiffness (HP:0001387)2.54202449
90Abnormality of mucopolysaccharide metabolism (HP:0011020)2.53462977
91Abnormality of polysaccharide metabolism (HP:0011012)2.53462977
92Abnormality of glycosaminoglycan metabolism (HP:0004371)2.53462977
93Type 2 muscle fiber atrophy (HP:0003554)2.53157099
94Abnormality of the renal medulla (HP:0100957)2.52520703
95Median cleft lip (HP:0000161)2.52071055
96Anencephaly (HP:0002323)2.49106539
97Hypotelorism (HP:0000601)2.46885761
98Hypokinesia (HP:0002375)2.44487161
99Abnormality of cells of the erythroid lineage (HP:0012130)2.37187452
100Aplasia of the musculature (HP:0100854)2.37069368
101Dysautonomia (HP:0002459)2.37006635
102Aplasia/Hypoplasia of the sacrum (HP:0008517)2.36722880
103Diaphragmatic weakness (HP:0009113)2.35843643
104Abnormal number of erythroid precursors (HP:0012131)2.33820223
105Growth hormone excess (HP:0000845)2.33604396
106* Nephrogenic diabetes insipidus (HP:0009806)2.31242070
107Acute lymphatic leukemia (HP:0006721)2.31029728
108Decreased lacrimation (HP:0000633)2.27100984
109Sclerocornea (HP:0000647)2.24717272
110Hypochromic anemia (HP:0001931)2.23695781
111Abnormality of the labia minora (HP:0012880)2.22172966
112* Postaxial hand polydactyly (HP:0001162)2.21475592
113IgA deficiency (HP:0002720)2.20882964
114Short chin (HP:0000331)2.19910906
115Capillary hemangiomas (HP:0005306)2.17224201
116Hamartoma (HP:0010566)2.13767140
117Aplasia/Hypoplasia of the tongue (HP:0010295)2.11855887
118Congenital hepatic fibrosis (HP:0002612)2.11775395
119Increased number of teeth (HP:0011069)2.11549106
120Clumsiness (HP:0002312)2.09666592
121Choanal stenosis (HP:0000452)2.09559546
122Volvulus (HP:0002580)2.05059901
123Pancreatic islet-cell hyperplasia (HP:0004510)2.03155022
124Amelogenesis imperfecta (HP:0000705)2.00495967
125Hypotrichosis (HP:0001006)1.99581751
126* Vaginal atresia (HP:0000148)1.98454383
127Abnormality of the anterior horn cell (HP:0006802)1.96704487
128Degeneration of anterior horn cells (HP:0002398)1.96704487
129Gastrointestinal atresia (HP:0002589)1.95651901
130Abnormality of the ileum (HP:0001549)1.94671637
131Polyphagia (HP:0002591)1.94631757
132Bulbar palsy (HP:0001283)1.94587058
133Bell-shaped thorax (HP:0001591)1.92987444
134* Genital tract atresia (HP:0001827)1.92510455
135Male pseudohermaphroditism (HP:0000037)1.92504995
136Reticulocytopenia (HP:0001896)1.89369370
137Amniotic constriction ring (HP:0009775)1.88342269
138Abnormality of placental membranes (HP:0011409)1.88342269
139Short 5th finger (HP:0009237)1.85419309
140Hypoplasia of the ulna (HP:0003022)1.84234641
141Popliteal pterygium (HP:0009756)1.83065402
142Aplasia/Hypoplasia of the spleen (HP:0010451)1.83029354
143Preaxial hand polydactyly (HP:0001177)1.82309749
144Bowed forearm bones (HP:0003956)1.82293133
145Down-sloping shoulders (HP:0200021)1.80626361
146Tubulointerstitial nephritis (HP:0001970)1.77844336
147* Poor coordination (HP:0002370)1.77692735
148Oculomotor apraxia (HP:0000657)1.77307283
149Asplenia (HP:0001746)1.75672943
150Sleep apnea (HP:0010535)1.75072283
151Chronic otitis media (HP:0000389)1.74542907
152Optic nerve coloboma (HP:0000588)1.72767310
153Failure to thrive in infancy (HP:0001531)1.68733029
154Hyperactive renin-angiotensin system (HP:0000841)1.66585927
155Absent rod-and cone-mediated responses on ERG (HP:0007688)1.66503441
156Hand muscle atrophy (HP:0009130)1.65864408
157* Specific learning disability (HP:0001328)1.62935330
158Tubular atrophy (HP:0000092)1.62741867
159Type II lissencephaly (HP:0007260)1.62683962
160Synostosis involving the elbow (HP:0003938)1.62359938
161Humeroradial synostosis (HP:0003041)1.62359938
162Nephropathy (HP:0000112)1.61272542
163Renal dysplasia (HP:0000110)1.59609689
164Narrow forehead (HP:0000341)1.58847923
165Broad distal phalanx of finger (HP:0009836)1.58158437
166* Broad foot (HP:0001769)1.57270737
167Retinal dysplasia (HP:0007973)1.55682944
168Hip dysplasia (HP:0001385)1.53937555
169* Retinitis pigmentosa (HP:0000510)1.52717091
170Septo-optic dysplasia (HP:0100842)1.51086139
171Renal salt wasting (HP:0000127)1.44460146
172Abnormal rod and cone electroretinograms (HP:0008323)1.42672010
173Abnormality of the middle phalanges of the toes (HP:0010183)1.41693217
174Maternal diabetes (HP:0009800)1.37756196
175Short femoral neck (HP:0100864)1.36746308
176Holoprosencephaly (HP:0001360)1.35323773
177* Left ventricular hypertrophy (HP:0001712)1.34972168
178Stage 5 chronic kidney disease (HP:0003774)1.34512849
179Abnormality of the lower motor neuron (HP:0002366)1.34353887
180Anophthalmia (HP:0000528)1.34014512
181Anosmia (HP:0000458)1.32865513
182* Aganglionic megacolon (HP:0002251)1.31070128
183* Aplasia/Hypoplasia of the lens (HP:0008063)1.28418811
184Abnormality of dentin (HP:0010299)1.28066836
185Facial cleft (HP:0002006)1.24917125
186Meningocele (HP:0002435)1.24860437
187Hepatoblastoma (HP:0002884)1.24492711
188Epileptic encephalopathy (HP:0200134)1.24325458
189Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.23833638
190Short thorax (HP:0010306)1.23266858
191Abnormal drinking behavior (HP:0030082)1.22588322
192Polydipsia (HP:0001959)1.22588322
193Agitation (HP:0000713)1.22303932
194Neoplasm of the heart (HP:0100544)1.19439720

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.11631787
2ICK5.10023173
3DDR24.41813909
4MAP3K64.00934508
5MAP3K113.41985062
6PIM23.29249765
7MARK13.00435472
8MAP3K42.96682099
9MATK2.82213192
10DAPK12.68482665
11PINK12.61230758
12UHMK12.57125470
13YES12.54209710
14MAP2K72.49044151
15EPHA42.38466897
16FGR2.36569743
17TYRO32.34495838
18BCKDK2.26187745
19CASK2.20249507
20PRKD22.06364771
21CDK72.02759879
22BCR2.02084377
23DYRK1B1.94582395
24ARAF1.87609032
25CSK1.74887662
26CSNK1G21.74792135
27MAP4K21.71600893
28BMX1.67443498
29NME11.67287453
30EPHB21.65634372
31CSNK1G31.59696054
32MAP2K41.59569582
33CSNK1A1L1.49222805
34LIMK11.49066338
35BUB11.48837048
36CAMKK11.48547355
37RPS6KL11.48447523
38RPS6KC11.48447523
39PIM11.47791219
40MAPK131.45670459
41DYRK31.41296132
42MARK21.40888765
43CDC71.36347598
44PDGFRA1.34955280
45RPS6KA61.34007052
46VRK21.23199171
47RPS6KA21.20812802
48EPHA21.17372795
49CHEK21.10713920
50WEE11.10326710
51PLK11.09896694
52TRPM71.09342788
53NME21.08976439
54SIK21.08588344
55LATS21.07949805
56PRPF4B1.02468935
57TESK21.01109755
58MINK11.00209536
59CDK50.96012254
60DYRK1A0.95974679
61PHKG10.95235868
62PHKG20.95235868
63ATR0.94762310
64MAPK110.94344228
65ERBB30.93034308
66AKT30.92718801
67TAOK20.91098636
68CDK60.90889242
69DYRK20.88537367
70CDK80.86622295
71PRKCG0.85453062
72GSK3A0.84255583
73STK160.84129395
74EPHA30.81928148
75ERBB20.81324422
76MAP2K20.79934268
77AURKA0.79891245
78MAP3K100.78107577
79VRK10.77227261
80CDC42BPA0.76670221
81EPHB10.75757399
82TLK10.75041161
83CCNB10.74456596
84CAMKK20.73292010
85GRK60.71482172
86EIF2AK10.71079027
87MAPKAPK30.70377332
88KDR0.70097106
89GRK10.70043812
90INSRR0.69181401
91RPS6KA10.68950522
92MAP3K120.68678154
93PRKCZ0.66107344
94CSNK2A10.65879008
95SIK30.63806692
96HIPK20.63378457
97PTK2B0.62043323
98SMG10.61531081
99LYN0.61189664
100MAP3K90.61089832
101PAK60.60856722
102LRRK20.60139308
103PASK0.59795203
104NTRK10.59689039
105PRKD30.59114182
106PAK30.57468025
107RPS6KB20.56716622
108ABL20.56423864
109CSNK1A10.54762499
110CAMK2A0.53443780
111PKN10.53376016
112RAF10.50419081
113AURKB0.50059302
114MAPK40.50002094
115PRKACA0.49503255
116MAP3K70.49099087
117SGK4940.47371030
118SGK2230.47371030
119STK110.47180434
120CDK20.47166082
121NEK20.47058372
122TNK20.46569929
123CDK11A0.46118386
124BRSK10.44837166
125PNCK0.44516002
126WNK30.43763456
127ADRBK20.43664648
128CSNK2A20.43475959
129CDK180.42270639
130CDK190.42188590
131BLK0.41783536
132CDK150.41464207
133DAPK30.40773843
134CAMK1D0.40590535
135RPS6KA40.39016851
136RPS6KB10.38994756
137MAP4K10.37651571
138PRKCI0.37036547
139MAPKAPK20.36635117
140CHEK10.36486450
141CAMK10.35526099
142MAPK30.35218840
143PRKDC0.35208309
144MKNK20.35170519
145PRKD10.32871158
146MKNK10.32756457
147PRKCE0.32721461
148CAMK2B0.31821850
149ATM0.31691574
150BRSK20.31162825
151CAMK2G0.28069834
152CDK140.27727199
153NEK10.27633205
154TESK10.27270945
155PAK10.27255887
156CDK10.27193161
157BRAF0.26033371
158CSNK1G10.25308681
159PRKCD0.25235767
160ILK0.24723025
161NTRK20.24449844
162MAPK10.24277215
163ACVR1B0.23408091
164EGFR0.21615815
165IKBKB0.21032040
166MAPK140.20512682
167PRKAA10.20333543

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034305.64637452
2DNA replication_Homo sapiens_hsa030305.37746991
3Base excision repair_Homo sapiens_hsa034105.09864879
4Phenylalanine metabolism_Homo sapiens_hsa003603.60892150
5Fatty acid biosynthesis_Homo sapiens_hsa000613.42488555
6Ribosome_Homo sapiens_hsa030103.22087999
7Nucleotide excision repair_Homo sapiens_hsa034203.05572235
8Homologous recombination_Homo sapiens_hsa034403.05363654
9Nicotine addiction_Homo sapiens_hsa050332.96958062
10Spliceosome_Homo sapiens_hsa030402.90961573
11Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.76419091
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.68487328
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.51676782
14Cocaine addiction_Homo sapiens_hsa050302.42909141
15Phototransduction_Homo sapiens_hsa047442.36944911
16Proteasome_Homo sapiens_hsa030502.30002329
17Chemical carcinogenesis_Homo sapiens_hsa052042.24635782
18Cardiac muscle contraction_Homo sapiens_hsa042602.24403719
19Tyrosine metabolism_Homo sapiens_hsa003502.24082709
20Axon guidance_Homo sapiens_hsa043602.14728551
21Fanconi anemia pathway_Homo sapiens_hsa034602.13476096
22RNA transport_Homo sapiens_hsa030132.10100557
23Synaptic vesicle cycle_Homo sapiens_hsa047212.03172784
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.99977899
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.99653295
26Histidine metabolism_Homo sapiens_hsa003401.85963112
27Sulfur relay system_Homo sapiens_hsa041221.85780526
28beta-Alanine metabolism_Homo sapiens_hsa004101.80202451
29Cell cycle_Homo sapiens_hsa041101.79242223
30mRNA surveillance pathway_Homo sapiens_hsa030151.73584714
31RNA polymerase_Homo sapiens_hsa030201.71983269
32Pyrimidine metabolism_Homo sapiens_hsa002401.64493983
33p53 signaling pathway_Homo sapiens_hsa041151.52959058
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.52195022
35GABAergic synapse_Homo sapiens_hsa047271.49300043
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.46708370
37Collecting duct acid secretion_Homo sapiens_hsa049661.44616087
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.42409655
39Dopaminergic synapse_Homo sapiens_hsa047281.39672512
40Regulation of autophagy_Homo sapiens_hsa041401.38990379
41Arginine and proline metabolism_Homo sapiens_hsa003301.36238526
42Notch signaling pathway_Homo sapiens_hsa043301.34199157
43Glutamatergic synapse_Homo sapiens_hsa047241.32905853
44Hedgehog signaling pathway_Homo sapiens_hsa043401.31824045
45Amphetamine addiction_Homo sapiens_hsa050311.27699688
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.24033854
47Circadian rhythm_Homo sapiens_hsa047101.23347293
48Folate biosynthesis_Homo sapiens_hsa007901.22307315
49RNA degradation_Homo sapiens_hsa030181.19334138
50Oxidative phosphorylation_Homo sapiens_hsa001901.16266171
51Parkinsons disease_Homo sapiens_hsa050121.15754594
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15459372
53Morphine addiction_Homo sapiens_hsa050321.14844962
54Biosynthesis of amino acids_Homo sapiens_hsa012301.14743031
55Peroxisome_Homo sapiens_hsa041461.14740431
56Linoleic acid metabolism_Homo sapiens_hsa005911.12678791
57Vibrio cholerae infection_Homo sapiens_hsa051101.10050785
58Circadian entrainment_Homo sapiens_hsa047131.09730700
59Hippo signaling pathway_Homo sapiens_hsa043901.09160209
60Taste transduction_Homo sapiens_hsa047421.08966457
61Primary immunodeficiency_Homo sapiens_hsa053401.08346477
62Huntingtons disease_Homo sapiens_hsa050161.06005549
63One carbon pool by folate_Homo sapiens_hsa006700.99076332
64Shigellosis_Homo sapiens_hsa051310.97924367
65Bladder cancer_Homo sapiens_hsa052190.97806895
66Basal transcription factors_Homo sapiens_hsa030220.95992207
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95558826
68Non-homologous end-joining_Homo sapiens_hsa034500.93671065
69Basal cell carcinoma_Homo sapiens_hsa052170.93380715
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92290239
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90112504
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86234327
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.82508702
74Serotonergic synapse_Homo sapiens_hsa047260.80038470
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79529490
76Insulin secretion_Homo sapiens_hsa049110.78506238
77Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.77690237
78Olfactory transduction_Homo sapiens_hsa047400.77562869
79Melanogenesis_Homo sapiens_hsa049160.75336877
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74611642
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.74585747
82Glutathione metabolism_Homo sapiens_hsa004800.73613995
83Tight junction_Homo sapiens_hsa045300.73490296
84mTOR signaling pathway_Homo sapiens_hsa041500.73096178
85Retinol metabolism_Homo sapiens_hsa008300.72987953
86Cholinergic synapse_Homo sapiens_hsa047250.72721250
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72620132
88Salivary secretion_Homo sapiens_hsa049700.72603014
89Wnt signaling pathway_Homo sapiens_hsa043100.70879298
90TGF-beta signaling pathway_Homo sapiens_hsa043500.68149992
91Legionellosis_Homo sapiens_hsa051340.66883729
92Purine metabolism_Homo sapiens_hsa002300.66408432
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.66385273
94Oxytocin signaling pathway_Homo sapiens_hsa049210.65304353
95N-Glycan biosynthesis_Homo sapiens_hsa005100.63291601
96Oocyte meiosis_Homo sapiens_hsa041140.61351026
97Colorectal cancer_Homo sapiens_hsa052100.61196490
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60863056
99Fructose and mannose metabolism_Homo sapiens_hsa000510.57739591
100Epstein-Barr virus infection_Homo sapiens_hsa051690.56797449
101Fatty acid metabolism_Homo sapiens_hsa012120.56728709
102cAMP signaling pathway_Homo sapiens_hsa040240.56656292
103Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56473318
104Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56288313
105Choline metabolism in cancer_Homo sapiens_hsa052310.52656815
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51579717
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.51451961
108Alzheimers disease_Homo sapiens_hsa050100.50311541
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50182979
110Butanoate metabolism_Homo sapiens_hsa006500.49611701
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.49480452
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48113154
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47757680
114Dilated cardiomyopathy_Homo sapiens_hsa054140.46027006
115Adherens junction_Homo sapiens_hsa045200.45195199
116Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44920532
117Galactose metabolism_Homo sapiens_hsa000520.43624620
118Viral carcinogenesis_Homo sapiens_hsa052030.43581645
119VEGF signaling pathway_Homo sapiens_hsa043700.43146722
120Alcoholism_Homo sapiens_hsa050340.42236976
121Herpes simplex infection_Homo sapiens_hsa051680.41606892
122Maturity onset diabetes of the young_Homo sapiens_hsa049500.40514529
123Protein export_Homo sapiens_hsa030600.40035010
124Calcium signaling pathway_Homo sapiens_hsa040200.39186891
125Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38987430
126Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37330836
127Fatty acid elongation_Homo sapiens_hsa000620.36856836
128Sphingolipid metabolism_Homo sapiens_hsa006000.36580630
129Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36353708
130Caffeine metabolism_Homo sapiens_hsa002320.36056302
131Gastric acid secretion_Homo sapiens_hsa049710.35412955
132HTLV-I infection_Homo sapiens_hsa051660.35000622
133Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34446653
134Thyroid cancer_Homo sapiens_hsa052160.32465014
135Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32013293
136Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30867004
137MicroRNAs in cancer_Homo sapiens_hsa052060.30098051
138Long-term depression_Homo sapiens_hsa047300.28337745
139ABC transporters_Homo sapiens_hsa020100.27810921
140Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.26737139
141Arachidonic acid metabolism_Homo sapiens_hsa005900.25716670
142Metabolic pathways_Homo sapiens_hsa011000.24983303
143alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24464863
144Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.24457847
145AMPK signaling pathway_Homo sapiens_hsa041520.24340527
146Viral myocarditis_Homo sapiens_hsa054160.24140469
147Hepatitis B_Homo sapiens_hsa051610.24094862
148Chronic myeloid leukemia_Homo sapiens_hsa052200.23840275
149Gap junction_Homo sapiens_hsa045400.23205936
150Acute myeloid leukemia_Homo sapiens_hsa052210.23041943
151Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.22174711
152Fatty acid degradation_Homo sapiens_hsa000710.22140776
153Cysteine and methionine metabolism_Homo sapiens_hsa002700.20460677
154Systemic lupus erythematosus_Homo sapiens_hsa053220.19290963
155Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.19207468
156Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19089275
157Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.18479011
158Measles_Homo sapiens_hsa051620.16175442
159Cyanoamino acid metabolism_Homo sapiens_hsa004600.15806931
160Pentose and glucuronate interconversions_Homo sapiens_hsa000400.15476597
161Small cell lung cancer_Homo sapiens_hsa052220.13861245
162Regulation of actin cytoskeleton_Homo sapiens_hsa048100.13496445
163Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.12583708
164Lysine degradation_Homo sapiens_hsa003100.11404487
165PI3K-Akt signaling pathway_Homo sapiens_hsa041510.11337254
166Melanoma_Homo sapiens_hsa052180.10712887
167Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.06902157
168Pathways in cancer_Homo sapiens_hsa052000.06889634
169Steroid biosynthesis_Homo sapiens_hsa001000.06656897
170ErbB signaling pathway_Homo sapiens_hsa040120.04797092

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